locus-tag	class	description
WBM_RS00005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WBM_RS00025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WBM_RS00070	COG0477	Major facilitator Superfamily
WBM_RS00075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WBM_RS00085	COG4133	protoheme IX ABC transporter activity
WBM_RS00090	COG0772	Belongs to the SEDS family
WBM_RS00095	COG0651	ATP synthesis coupled electron transport
WBM_RS00115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WBM_RS00135	COG1104	cysteine desulfurase activity
WBM_RS00140	COG2945	thiolester hydrolase activity
WBM_RS00155	COG0316	Belongs to the HesB IscA family
WBM_RS00160	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WBM_RS00165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WBM_RS00165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WBM_RS00175	COG1104	cysteine desulfurase activity
WBM_RS00195	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WBM_RS00225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WBM_RS00235	COG1178	ABC-type Fe3 transport system permease component
WBM_RS00240	COG2967	ApaG domain
WBM_RS00245	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WBM_RS00250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WBM_RS00265	COG1113	amino acid transport
WBM_RS00270	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WBM_RS00285	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WBM_RS00295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WBM_RS00315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WBM_RS00330	COG0750	zinc metalloprotease
WBM_RS00345	COG0776	regulation of translation
WBM_RS00350	COG0539	negative regulation of cytoplasmic translation
WBM_RS00380	COG0489	protein tyrosine kinase activity
WBM_RS00385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WBM_RS00425	COG4536	flavin adenine dinucleotide binding
WBM_RS00430	COG3750	Belongs to the UPF0335 family
WBM_RS00435	COG0163	prenyltransferase activity
WBM_RS00440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WBM_RS00460	COG0442	prolyl-tRNA aminoacylation
WBM_RS00465	COG0736	holo-[acyl-carrier-protein] synthase activity
WBM_RS00470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WBM_RS00475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WBM_RS00495	COG0307	riboflavin synthase, alpha
WBM_RS00505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WBM_RS00510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WBM_RS00535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WBM_RS00540	COG0193	aminoacyl-tRNA hydrolase activity
WBM_RS00565	COG1830	Aldolase
WBM_RS00585	COG0167	dihydroorotate dehydrogenase activity
WBM_RS00590	COG0571	ribonuclease III activity
WBM_RS00605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WBM_RS00610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WBM_RS00650	COG0275	rRNA processing
WBM_RS00665	COG0508	dehydrogenase complex catalyzes the overall conversion of
WBM_RS00695	COG0024	Methionine aminopeptidase
WBM_RS00700	COG0849	cell division
WBM_RS00705	COG0242	peptide deformylase activity
WBM_RS00710	COG1573	uracil-dna glycosylase
WBM_RS00720	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WBM_RS00725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WBM_RS00730	COG0148	phosphopyruvate hydratase activity
WBM_RS00735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WBM_RS00745	COG0728	peptidoglycan biosynthetic process
WBM_RS00760	COG3474	cytochrome
WBM_RS00765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WBM_RS00770	COG0649	NAD binding
WBM_RS00775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WBM_RS00780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WBM_RS00785	COG2202	Pas domain
WBM_RS00785	COG2205	protein histidine kinase activity
WBM_RS00790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WBM_RS00795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WBM_RS00800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WBM_RS00810	COG0156	8-amino-7-oxononanoate synthase activity
WBM_RS00845	COG0326	Molecular chaperone. Has ATPase activity
WBM_RS00885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WBM_RS00900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WBM_RS00905	COG0037	tRNA processing
WBM_RS00910	COG2885	chlorophyll binding
WBM_RS00925	COG0482	sulfurtransferase activity
WBM_RS00945	COG1494	fructose-1,6-bisphosphatase
WBM_RS00955	COG0012	GTP binding
WBM_RS00960	COG0617	tRNA 3'-terminal CCA addition
WBM_RS00995	COG0477	Major facilitator Superfamily
WBM_RS01005	COG0590	tRNA wobble adenosine to inosine editing
WBM_RS01010	COG0504	CTP synthase activity
WBM_RS01025	COG1074	ATP-dependent DNA helicase activity
WBM_RS01030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WBM_RS01040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WBM_RS01055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WBM_RS01065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WBM_RS01075	COG0542	response to heat
WBM_RS01080	COG2902	Dehydrogenase
WBM_RS01090	COG0745	RESPONSE REGULATOR receiver
WBM_RS01090	COG3706	GGDEF domain
WBM_RS01115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WBM_RS01125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WBM_RS01130	COG0424	maF-like protein
WBM_RS01140	COG0358	DNA primase activity
WBM_RS01145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WBM_RS01155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WBM_RS01165	COG1115	amino acid carrier protein
WBM_RS01200	COG2814	Major facilitator Superfamily
WBM_RS01215	COG1132	(ABC) transporter
WBM_RS01225	COG0018	arginyl-trna synthetase
WBM_RS01235	COG0564	pseudouridine synthase activity
WBM_RS01240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WBM_RS01250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WBM_RS01250	COG0574	Belongs to the PEP-utilizing enzyme family
WBM_RS01260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WBM_RS01265	COG0629	single-stranded DNA binding
WBM_RS01300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WBM_RS01315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WBM_RS01320	COG0612	Peptidase, M16
WBM_RS01345	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WBM_RS01350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WBM_RS01355	COG0336	Belongs to the RNA methyltransferase TrmD family
WBM_RS01360	COG0335	large ribosomal subunit rRNA binding
WBM_RS01370	COG0581	inorganic phosphate transmembrane transporter activity
WBM_RS01375	COG0047	phosphoribosylformylglycinamidine synthase activity
WBM_RS01385	COG0321	lipoyl(octanoyl) transferase activity
WBM_RS01390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WBM_RS01420	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WBM_RS01425	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WBM_RS01430	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WBM_RS01435	COG0039	L-malate dehydrogenase activity
WBM_RS01440	COG0084	hydrolase, TatD family'
WBM_RS01445	COG0494	nUDIX hydrolase
WBM_RS01455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WBM_RS01475	COG0632	four-way junction helicase activity
WBM_RS01480	COG2255	four-way junction helicase activity
WBM_RS01490	COG2094	Belongs to the DNA glycosylase MPG family
WBM_RS01495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WBM_RS01500	COG0543	2 iron, 2 sulfur cluster binding
WBM_RS01500	COG0493	'glutamate synthase
WBM_RS01515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WBM_RS01520	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WBM_RS01525	COG0237	dephospho-CoA kinase activity
WBM_RS01565	COG0653	protein targeting
WBM_RS01595	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WBM_RS01600	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
WBM_RS01605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WBM_RS01615	COG0174	glutamine synthetase
WBM_RS01620	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WBM_RS01640	COG3736	Type IV secretory pathway, component VirB8
WBM_RS01655	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WBM_RS01670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WBM_RS01670	COG2890	protein-(glutamine-N5) methyltransferase activity
WBM_RS01675	COG1138	Cytochrome C-type biogenesis protein
WBM_RS01695	COG1686	Belongs to the peptidase S11 family
WBM_RS01705	COG0717	Belongs to the dCTP deaminase family
WBM_RS01720	COG2239	Acts as a magnesium transporter
WBM_RS01725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WBM_RS01750	COG0805	protein transport
WBM_RS01765	COG0305	Participates in initiation and elongation during chromosome replication
WBM_RS01775	COG1714	RDD family
WBM_RS01790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WBM_RS01795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WBM_RS01825	COG0109	protoheme IX farnesyltransferase activity
WBM_RS01830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WBM_RS01835	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WBM_RS01840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WBM_RS01865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WBM_RS01870	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WBM_RS01875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WBM_RS01885	COG0203	ribosomal protein L17
WBM_RS01890	COG0202	RNA polymerase activity
WBM_RS01895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WBM_RS01900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WBM_RS01905	COG0563	adenylate kinase activity
WBM_RS01910	COG0201	protein transport
WBM_RS01915	COG0200	Binds to the 23S rRNA
WBM_RS01920	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WBM_RS01925	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WBM_RS01930	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WBM_RS01935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WBM_RS01940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WBM_RS01945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WBM_RS01950	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WBM_RS01955	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WBM_RS01960	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WBM_RS01970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WBM_RS01975	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WBM_RS01980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WBM_RS01985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WBM_RS01990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WBM_RS02000	COG0088	Forms part of the polypeptide exit tunnel
WBM_RS02005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WBM_RS02015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WBM_RS02020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WBM_RS02025	COG0049	tRNA binding
WBM_RS02030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WBM_RS02050	COG0354	folic acid binding
WBM_RS02055	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WBM_RS02060	COG0459	protein refolding
WBM_RS02100	COG0756	dUTP diphosphatase activity
WBM_RS02105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WBM_RS02110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WBM_RS02115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WBM_RS02120	COG2814	Major facilitator Superfamily
WBM_RS02135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WBM_RS02145	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WBM_RS02150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WBM_RS02155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WBM_RS02165	COG0473	3-isopropylmalate dehydrogenase activity
WBM_RS02180	COG0752	glycyl-tRNA synthetase alpha subunit
WBM_RS02185	COG0751	glycine-tRNA ligase activity
WBM_RS02190	COG0322	excinuclease ABC activity
WBM_RS02200	COG0113	porphobilinogen synthase activity
WBM_RS02210	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WBM_RS02215	COG1034	ATP synthesis coupled electron transport
WBM_RS02235	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WBM_RS02260	COG0567	Dehydrogenase, E1 component
WBM_RS02265	COG1230	cation diffusion facilitator family transporter
WBM_RS02280	COG0540	Belongs to the ATCase OTCase family
WBM_RS02290	COG1758	RNA polymerase activity
WBM_RS02315	COG1006	Multisubunit Na H antiporter MnhC subunit
WBM_RS02320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WBM_RS02330	COG0567	Dehydrogenase, E1 component
WBM_RS02340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WBM_RS02345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WBM_RS02350	COG1840	ABC-type Fe3 transport system, periplasmic component
WBM_RS02360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WBM_RS02365	COG0254	rRNA binding
WBM_RS02370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WBM_RS02375	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WBM_RS02415	COG0723	plastoquinol--plastocyanin reductase activity
WBM_RS02420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WBM_RS02430	COG0149	triose-phosphate isomerase activity
WBM_RS02435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WBM_RS02435	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WBM_RS02455	COG0138	bifunctional purine biosynthesis protein purh
WBM_RS02460	COG0124	histidyl-tRNA synthetase
WBM_RS02480	COG0196	riboflavin kinase activity
WBM_RS02485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WBM_RS02490	COG0612	Peptidase, M16
WBM_RS02505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WBM_RS02510	COG1863	multisubunit Na H antiporter MnhE subunit
WBM_RS02520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WBM_RS02525	COG1115	amino acid carrier protein
WBM_RS02535	COG1183	phosphatidylcholine synthase activity
WBM_RS02540	COG0688	phosphatidylethanolamine metabolic process
WBM_RS02545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WBM_RS02550	COG0101	tRNA pseudouridine synthase activity
WBM_RS02555	COG0592	DNA-directed DNA polymerase activity
WBM_RS02565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WBM_RS02570	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WBM_RS02580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WBM_RS02600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WBM_RS02620	COG0527	aspartate kinase activity
WBM_RS02630	COG0861	Integral membrane protein TerC family
WBM_RS02635	COG0519	Catalyzes the synthesis of GMP from XMP
WBM_RS02635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WBM_RS02645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WBM_RS02655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WBM_RS02665	COG1053	succinate dehydrogenase
WBM_RS02675	COG2171	N-acyltransferase activity
WBM_RS02695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WBM_RS02705	COG0439	Biotin carboxylase
WBM_RS02710	COG1612	heme a metabolic process
WBM_RS02730	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WBM_RS02735	COG0356	it plays a direct role in the translocation of protons across the membrane
WBM_RS02740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WBM_RS02740	COG0072	phenylalanine-tRNA ligase activity
WBM_RS02745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WBM_RS02755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WBM_RS02790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WBM_RS02795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WBM_RS02800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WBM_RS02815	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WBM_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
WBM_RS02835	COG1295	ribonuclease BN
WBM_RS02845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WBM_RS02875	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WBM_RS02880	COG2009	succinate dehydrogenase
WBM_RS02900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WBM_RS02905	COG0670	Belongs to the BI1 family
WBM_RS02910	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WBM_RS02920	COG0626	cystathionine gamma-synthase activity
WBM_RS02925	COG0271	Belongs to the BolA IbaG family
WBM_RS02930	COG0443	Heat shock 70 kDa protein
WBM_RS02935	COG1530	ribonuclease E activity
WBM_RS02940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WBM_RS02960	COG0587	DNA-directed DNA polymerase activity
WBM_RS02965	COG0360	Binds together with S18 to 16S ribosomal RNA
WBM_RS02970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WBM_RS02975	COG0359	binds to the 23S rRNA
WBM_RS02980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WBM_RS02990	COG0114	fumarate hydratase activity
WBM_RS02995	COG3088	subunit of a heme lyase
WBM_RS02995	COG4235	cytochrome complex assembly
WBM_RS03010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WBM_RS03040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WBM_RS03055	COG1268	BioY protein
WBM_RS03065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WBM_RS03075	COG0045	succinate-CoA ligase (ADP-forming) activity
WBM_RS03130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WBM_RS03145	COG0228	four-way junction DNA binding
WBM_RS03150	COG0142	geranyltranstransferase activity
WBM_RS03155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WBM_RS03175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WBM_RS03185	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WBM_RS03210	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WBM_RS03210	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WBM_RS03210	COG0506	proline dehydrogenase activity
WBM_RS03220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WBM_RS03230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WBM_RS03235	COG1999	signal sequence binding
WBM_RS03285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WBM_RS03290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WBM_RS03300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WBM_RS03305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WBM_RS03310	COG0740	serine-type endopeptidase activity
WBM_RS03315	COG0544	peptidyl-prolyl cis-trans isomerase activity
WBM_RS03335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WBM_RS03345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WBM_RS03385	COG0450	alkyl hydroperoxide reductase
WBM_RS03390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WBM_RS03405	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WBM_RS03420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WBM_RS03440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WBM_RS03455	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WBM_RS03465	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WBM_RS03470	COG0194	GDP metabolic process
WBM_RS03490	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WBM_RS03505	COG1160	GTP binding
WBM_RS03520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WBM_RS03530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WBM_RS03565	COG0651	ATP synthesis coupled electron transport
WBM_RS03570	COG0343	queuine tRNA-ribosyltransferase activity
WBM_RS03575	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WBM_RS03585	COG0745	RESPONSE REGULATOR receiver
WBM_RS03590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WBM_RS03595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WBM_RS03610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WBM_RS03615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WBM_RS03650	COG0495	leucyl-tRNA aminoacylation
WBM_RS03695	COG0445	tRNA wobble uridine modification
WBM_RS03700	COG0006	proline dipeptidase activity
WBM_RS03710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WBM_RS03715	COG0416	fatty acid biosynthetic process
WBM_RS03720	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WBM_RS03725	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WBM_RS03730	COG1127	ABC transporter
WBM_RS03735	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WBM_RS03740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WBM_RS03740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WBM_RS03745	COG1007	ATP synthesis coupled electron transport
WBM_RS03750	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WBM_RS03755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WBM_RS03760	COG0713	ATP synthesis coupled electron transport
WBM_RS03805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WBM_RS03810	COG3485	protocatechuate 3,4-dioxygenase
WBM_RS03815	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WBM_RS03820	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WBM_RS03825	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WBM_RS03835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WBM_RS03845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WBM_RS03855	COG0009	L-threonylcarbamoyladenylate synthase
WBM_RS03875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WBM_RS03880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WBM_RS03885	COG1674	ftsk spoiiie
WBM_RS03900	COG0222	ribosome binding
WBM_RS03905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WBM_RS03910	COG0081	regulation of translation
WBM_RS03915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WBM_RS03920	COG0250	Participates in transcription elongation, termination and antitermination
WBM_RS03935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WBM_RS03950	COG0505	Belongs to the CarA family
WBM_RS03965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WBM_RS03970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WBM_RS04020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WBM_RS04025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WBM_RS04035	COG0508	dehydrogenase complex catalyzes the overall conversion of
WBM_RS04035	COG0022	dehydrogenase e1 component
WBM_RS04045	COG0481	GTPase activity
WBM_RS04080	COG0217	transcriptional regulatory protein
WBM_RS04095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WBM_RS04100	COG0280	phosphate acetyltransferase
WBM_RS04100	COG0281	malic enzyme
WBM_RS04125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WBM_RS04130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WBM_RS04135	COG3932	Exopolysaccharide synthesis, ExoD
WBM_RS04170	COG0126	phosphoglycerate kinase activity
WBM_RS04175	COG0492	ferredoxin-NADP+ reductase activity
WBM_RS04185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WBM_RS04195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WBM_RS04200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WBM_RS04205	COG0573	inorganic phosphate transmembrane transporter activity
WBM_RS04230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WBM_RS04235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WBM_RS04235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WBM_RS04240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WBM_RS04245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WBM_RS04250	COG1845	cytochrome c oxidase, subunit III
WBM_RS04260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WBM_RS04270	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WBM_RS04275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WBM_RS04300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WBM_RS04305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WBM_RS04310	COG0312	modulator of DNA gyrase
WBM_RS04315	COG1278	Cold shock
WBM_RS04370	COG1322	Protein conserved in bacteria
WBM_RS04400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WBM_RS04405	COG1121	(ABC) transporter
WBM_RS04410	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
WBM_RS04415	COG0105	UTP biosynthetic process
WBM_RS04425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WBM_RS04440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WBM_RS04445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WBM_RS04455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WBM_RS04455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WBM_RS04465	COG0312	modulator of DNA gyrase
WBM_RS04490	COG0708	Exodeoxyribonuclease III
WBM_RS04495	COG0628	permease
WBM_RS04500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WBM_RS04505	COG4974	Belongs to the 'phage' integrase family
WBM_RS04515	COG0268	Binds directly to 16S ribosomal RNA
WBM_RS04520	COG0372	Belongs to the citrate synthase family
WBM_RS04535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WBM_RS04540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WBM_RS04545	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WBM_RS04550	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WBM_RS04575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WBM_RS04585	COG0508	dehydrogenase complex catalyzes the overall conversion of
WBM_RS04605	COG3451	type IV secretory pathway VirB4
WBM_RS04620	COG2070	2-Nitropropane dioxygenase
WBM_RS04635	COG0552	protein localization to endoplasmic reticulum
WBM_RS04640	COG0822	iron-sulfur transferase activity
WBM_RS04645	COG0316	Belongs to the HesB IscA family
WBM_RS04655	COG0443	Heat shock 70 kDa protein
WBM_RS04660	COG0681	Belongs to the peptidase S26 family
WBM_RS04670	COG0154	amidase activity
WBM_RS04675	COG0187	DNA topoisomerase II activity
WBM_RS04700	COG0330	HflC and HflK could
WBM_RS04725	COG0556	nucleotide-excision repair
WBM_RS04730	COG2857	Cytochrome c1
WBM_RS04730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WBM_RS04735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WBM_RS04765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WBM_RS04780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WBM_RS04805	COG0484	heat shock protein binding
WBM_RS04810	COG0525	valine-tRNA ligase activity
WBM_RS04815	COG0284	orotidine-5'-phosphate decarboxylase activity
WBM_RS04830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WBM_RS04835	COG1301	dicarboxylic acid transport
WBM_RS04840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WBM_RS04860	COG0419	ATPase involved in DNA repair
WBM_RS04860	COG3704	protein secretion by the type IV secretion system
WBM_RS04865	COG3704	protein secretion by the type IV secretion system
WBM_RS04875	COG3704	protein secretion by the type IV secretion system
WBM_RS04880	COG3451	type IV secretory pathway VirB4
WBM_RS04890	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WBM_RS04905	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WBM_RS04915	COG0575	Belongs to the CDS family
WBM_RS04920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WBM_RS04925	COG0233	cytoplasmic translational termination
WBM_RS04930	COG0528	UMP kinase activity
WBM_RS04935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WBM_RS04940	COG0052	Belongs to the universal ribosomal protein uS2 family
WBM_RS04960	COG1253	flavin adenine dinucleotide binding
WBM_RS05535	COG0085	RNA polymerase activity
WBM_RS05535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WBM_RS05580	COG0230	Belongs to the bacterial ribosomal protein bL34 family