locus-tag	class	description
CO538_RS00005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CO538_RS00010	COG0436	Aminotransferase
CO538_RS00030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CO538_RS00035	COG0126	phosphoglycerate kinase activity
CO538_RS00050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CO538_RS00060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CO538_RS00065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CO538_RS00070	COG2801	Transposase and inactivated derivatives
CO538_RS00085	COG3344	reverse transcriptase
CO538_RS00090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CO538_RS00090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CO538_RS00095	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CO538_RS00100	COG0316	Belongs to the HesB IscA family
CO538_RS00115	COG2945	thiolester hydrolase activity
CO538_RS00120	COG1104	cysteine desulfurase activity
CO538_RS00125	COG0670	Belongs to the BI1 family
CO538_RS00130	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CO538_RS00150	COG3344	reverse transcriptase
CO538_RS00165	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CO538_RS00175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CO538_RS00200	COG0629	single-stranded DNA binding
CO538_RS00205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO538_RS00220	COG3344	reverse transcriptase
CO538_RS00240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CO538_RS00275	COG2801	Transposase and inactivated derivatives
CO538_RS00285	COG2801	Transposase and inactivated derivatives
CO538_RS00290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CO538_RS00295	COG0799	negative regulation of ribosome biogenesis
CO538_RS00305	COG1012	belongs to the aldehyde dehydrogenase family
CO538_RS00315	COG0494	nUDIX hydrolase
CO538_RS00320	COG0084	hydrolase, TatD family'
CO538_RS00325	COG0039	L-malate dehydrogenase activity
CO538_RS00330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO538_RS00335	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO538_RS00340	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO538_RS00345	COG0537	adenosine 5'-monophosphoramidase activity
CO538_RS00365	COG1090	epimerase
CO538_RS00375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO538_RS00380	COG0416	fatty acid biosynthetic process
CO538_RS00385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CO538_RS00390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CO538_RS00395	COG1127	ABC transporter
CO538_RS00400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CO538_RS00415	COG0543	2 iron, 2 sulfur cluster binding
CO538_RS00415	COG0493	'glutamate synthase
CO538_RS00420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO538_RS00435	COG0750	zinc metalloprotease
CO538_RS00450	COG0776	regulation of translation
CO538_RS00455	COG0539	negative regulation of cytoplasmic translation
CO538_RS00460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CO538_RS00480	COG2801	Transposase and inactivated derivatives
CO538_RS00505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CO538_RS00510	COG0045	succinate-CoA ligase (ADP-forming) activity
CO538_RS00525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CO538_RS00560	COG1475	DNA binding
CO538_RS00565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CO538_RS00565	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CO538_RS00580	COG3344	reverse transcriptase
CO538_RS00590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CO538_RS00595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CO538_RS00605	COG0156	8-amino-7-oxononanoate synthase activity
CO538_RS00615	COG0326	Molecular chaperone. Has ATPase activity
CO538_RS00630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CO538_RS00660	COG0666	response to abiotic stimulus
CO538_RS00665	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CO538_RS00670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO538_RS00675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO538_RS00680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO538_RS00685	COG0142	geranyltranstransferase activity
CO538_RS00695	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CO538_RS00700	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CO538_RS00715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CO538_RS00725	COG0105	UTP biosynthetic process
CO538_RS00730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CO538_RS00735	COG4536	flavin adenine dinucleotide binding
CO538_RS00740	COG3750	Belongs to the UPF0335 family
CO538_RS00745	COG0163	prenyltransferase activity
CO538_RS00750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO538_RS00765	COG0495	leucyl-tRNA aminoacylation
CO538_RS00780	COG0776	regulation of translation
CO538_RS00830	COG2801	Transposase and inactivated derivatives
CO538_RS00870	COG3344	reverse transcriptase
CO538_RS00885	COG0321	lipoyl(octanoyl) transferase activity
CO538_RS00905	COG0360	Binds together with S18 to 16S ribosomal RNA
CO538_RS00915	COG0359	binds to the 23S rRNA
CO538_RS00920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CO538_RS00935	COG2801	Transposase and inactivated derivatives
CO538_RS00950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO538_RS00995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CO538_RS00995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CO538_RS01005	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CO538_RS01020	COG2801	Transposase and inactivated derivatives
CO538_RS01060	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CO538_RS01075	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CO538_RS01100	COG3344	reverse transcriptase
CO538_RS01115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CO538_RS01120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CO538_RS01120	COG2857	Cytochrome c1
CO538_RS01125	COG0556	nucleotide-excision repair
CO538_RS01130	COG2801	Transposase and inactivated derivatives
CO538_RS01145	COG0484	heat shock protein binding
CO538_RS01155	COG0124	histidyl-tRNA synthetase
CO538_RS01160	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CO538_RS01170	COG0531	amino acid
CO538_RS01175	COG1113	amino acid transport
CO538_RS01185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CO538_RS01190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CO538_RS01200	COG1178	ABC-type Fe3 transport system permease component
CO538_RS01205	COG1054	Belongs to the UPF0176 family
CO538_RS01250	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CO538_RS01260	COG3451	type IV secretory pathway VirB4
CO538_RS01265	COG3704	protein secretion by the type IV secretion system
CO538_RS01270	COG3704	protein secretion by the type IV secretion system
CO538_RS01275	COG3704	protein secretion by the type IV secretion system
CO538_RS01275	COG1340	protein secretion by the type IV secretion system
CO538_RS01295	COG2801	Transposase and inactivated derivatives
CO538_RS01315	COG3344	reverse transcriptase
CO538_RS01325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CO538_RS01330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CO538_RS01340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO538_RS01340	COG0072	phenylalanine-tRNA ligase activity
CO538_RS01350	COG0356	it plays a direct role in the translocation of protons across the membrane
CO538_RS01355	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO538_RS01375	COG1612	heme a metabolic process
CO538_RS01380	COG4770	biotin carboxylase activity
CO538_RS01390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CO538_RS01395	COG0071	Belongs to the small heat shock protein (HSP20) family
CO538_RS01400	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CO538_RS01415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CO538_RS01425	COG3827	peptidoglycan binding
CO538_RS01430	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CO538_RS01450	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CO538_RS01455	COG0343	queuine tRNA-ribosyltransferase activity
CO538_RS01465	COG0612	Peptidase, M16
CO538_RS01470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CO538_RS01515	COG0445	tRNA wobble uridine modification
CO538_RS01555	COG3451	type IV secretory pathway VirB4
CO538_RS01570	COG2070	2-Nitropropane dioxygenase
CO538_RS01580	COG0649	NAD binding
CO538_RS01590	COG3344	reverse transcriptase
CO538_RS01600	COG2801	Transposase and inactivated derivatives
CO538_RS01610	COG2801	Transposase and inactivated derivatives
CO538_RS01625	COG0745	RESPONSE REGULATOR receiver
CO538_RS01630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CO538_RS01635	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CO538_RS01650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CO538_RS01655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CO538_RS01690	COG0726	polysaccharide deacetylase
CO538_RS01695	COG0768	penicillin binding
CO538_RS01700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CO538_RS01705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CO538_RS01710	COG0740	serine-type endopeptidase activity
CO538_RS01715	COG0544	peptidyl-prolyl cis-trans isomerase activity
CO538_RS01740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CO538_RS01740	COG2890	protein-(glutamine-N5) methyltransferase activity
CO538_RS01745	COG3344	reverse transcriptase
CO538_RS01755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CO538_RS01760	COG0049	tRNA binding
CO538_RS01765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CO538_RS01770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CO538_RS01785	COG0250	Participates in transcription elongation, termination and antitermination
CO538_RS01790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CO538_RS01795	COG0081	regulation of translation
CO538_RS01800	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CO538_RS01805	COG0222	ribosome binding
CO538_RS01810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CO538_RS01810	COG0085	RNA polymerase activity
CO538_RS01825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CO538_RS01830	COG0151	Belongs to the GarS family
CO538_RS01840	COG0473	3-isopropylmalate dehydrogenase activity
CO538_RS01885	COG3344	reverse transcriptase
CO538_RS01915	COG2801	Transposase and inactivated derivatives
CO538_RS01935	COG2171	N-acyltransferase activity
CO538_RS01945	COG1053	succinate dehydrogenase
CO538_RS01955	COG0194	GDP metabolic process
CO538_RS01970	COG0540	Belongs to the ATCase OTCase family
CO538_RS01975	COG1840	ABC-type Fe3 transport system, periplasmic component
CO538_RS01985	COG2801	Transposase and inactivated derivatives
CO538_RS01995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CO538_RS02000	COG0254	rRNA binding
CO538_RS02005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CO538_RS02015	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CO538_RS02030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CO538_RS02050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CO538_RS02055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CO538_RS02060	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO538_RS02075	COG2801	Transposase and inactivated derivatives
CO538_RS02085	COG2801	Transposase and inactivated derivatives
CO538_RS02105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CO538_RS02110	COG2801	Transposase and inactivated derivatives
CO538_RS02120	COG0285	dihydrofolate synthase activity
CO538_RS02135	COG2867	negative regulation of translational initiation
CO538_RS02170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CO538_RS02175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CO538_RS02185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO538_RS02200	COG0101	tRNA pseudouridine synthase activity
CO538_RS02205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CO538_RS02220	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CO538_RS02240	COG0275	rRNA processing
CO538_RS02245	COG0477	Major facilitator Superfamily
CO538_RS02250	COG0024	Methionine aminopeptidase
CO538_RS02255	COG0849	cell division
CO538_RS02260	COG0242	peptide deformylase activity
CO538_RS02265	COG1573	uracil-dna glycosylase
CO538_RS02270	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CO538_RS02280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CO538_RS02295	COG1295	ribonuclease BN
CO538_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
CO538_RS02305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CO538_RS02315	COG0564	pseudouridine synthase activity
CO538_RS02325	COG0658	competence protein
CO538_RS02325	COG2333	competence protein COMEC
CO538_RS02345	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CO538_RS02365	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CO538_RS02370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CO538_RS02380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CO538_RS02390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO538_RS02410	COG3344	reverse transcriptase
CO538_RS02420	COG2801	Transposase and inactivated derivatives
CO538_RS02435	COG0493	'glutamate synthase
CO538_RS02435	COG0543	2 iron, 2 sulfur cluster binding
CO538_RS02440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO538_RS02450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CO538_RS02460	COG0482	sulfurtransferase activity
CO538_RS02475	COG2885	chlorophyll binding
CO538_RS02480	COG0037	tRNA processing
CO538_RS02485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CO538_RS02490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CO538_RS02500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CO538_RS02525	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO538_RS02565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CO538_RS02575	COG2205	protein histidine kinase activity
CO538_RS02580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CO538_RS02595	COG3344	reverse transcriptase
CO538_RS02610	COG0628	permease
CO538_RS02620	COG4974	Belongs to the 'phage' integrase family
CO538_RS02630	COG0268	Binds directly to 16S ribosomal RNA
CO538_RS02635	COG0372	Belongs to the citrate synthase family
CO538_RS02665	COG2255	four-way junction helicase activity
CO538_RS02670	COG0632	four-way junction helicase activity
CO538_RS02675	COG3474	cytochrome
CO538_RS02695	COG0839	Belongs to the complex I subunit 6 family
CO538_RS02700	COG0713	ATP synthesis coupled electron transport
CO538_RS02705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CO538_RS02710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO538_RS02715	COG1007	ATP synthesis coupled electron transport
CO538_RS02725	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CO538_RS02730	COG2801	Transposase and inactivated derivatives
CO538_RS02765	COG2801	Transposase and inactivated derivatives
CO538_RS02800	COG3344	reverse transcriptase
CO538_RS02830	COG0542	response to heat
CO538_RS02835	COG2902	Dehydrogenase
CO538_RS02850	COG1381	Involved in DNA repair and RecF pathway recombination
CO538_RS02880	COG2801	Transposase and inactivated derivatives
CO538_RS02885	COG2801	Transposase and inactivated derivatives
CO538_RS02895	COG0305	Participates in initiation and elongation during chromosome replication
CO538_RS02925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CO538_RS02930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CO538_RS02945	COG2801	Transposase and inactivated derivatives
CO538_RS02960	COG0174	glutamine synthetase
CO538_RS02965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO538_RS02980	COG3577	Aspartyl protease
CO538_RS03005	COG0756	dUTP diphosphatase activity
CO538_RS03015	COG3344	reverse transcriptase
CO538_RS03025	COG0450	alkyl hydroperoxide reductase
CO538_RS03035	COG2801	Transposase and inactivated derivatives
CO538_RS03040	COG3344	reverse transcriptase
CO538_RS03080	COG3344	reverse transcriptase
CO538_RS03095	COG2801	Transposase and inactivated derivatives
CO538_RS03105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CO538_RS03110	COG1121	(ABC) transporter
CO538_RS03130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO538_RS03135	COG1530	ribonuclease E activity
CO538_RS03145	COG0271	Belongs to the BolA IbaG family
CO538_RS03150	COG0626	cystathionine gamma-synthase activity
CO538_RS03160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CO538_RS03170	COG0009	L-threonylcarbamoyladenylate synthase
CO538_RS03195	COG0305	Participates in initiation and elongation during chromosome replication
CO538_RS03205	COG1714	RDD family
CO538_RS03215	COG2801	Transposase and inactivated derivatives
CO538_RS03230	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CO538_RS03235	COG0237	dephospho-CoA kinase activity
CO538_RS03245	COG3344	reverse transcriptase
CO538_RS03250	COG3344	reverse transcriptase
CO538_RS03265	COG3344	reverse transcriptase
CO538_RS03275	COG2801	Transposase and inactivated derivatives
CO538_RS03285	COG0666	response to abiotic stimulus
CO538_RS03290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO538_RS03305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO538_RS03315	COG2801	Transposase and inactivated derivatives
CO538_RS03325	COG3344	reverse transcriptase
CO538_RS03340	COG2801	Transposase and inactivated derivatives
CO538_RS03355	COG0805	protein transport
CO538_RS03380	COG3344	reverse transcriptase
CO538_RS03395	COG2801	Transposase and inactivated derivatives
CO538_RS03400	COG0617	tRNA 3'-terminal CCA addition
CO538_RS03405	COG1217	gtp-binding protein TYPA
CO538_RS03410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CO538_RS03410	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CO538_RS03425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO538_RS03440	COG1074	ATP-dependent DNA helicase activity
CO538_RS03495	COG0358	DNA primase activity
CO538_RS03500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CO538_RS03520	COG2801	Transposase and inactivated derivatives
CO538_RS03550	COG3344	reverse transcriptase
CO538_RS03555	COG2801	Transposase and inactivated derivatives
CO538_RS03570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CO538_RS03580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CO538_RS03595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CO538_RS03605	COG0575	Belongs to the CDS family
CO538_RS03610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CO538_RS03620	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO538_RS03625	COG3344	reverse transcriptase
CO538_RS03645	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CO538_RS03660	COG0012	GTP binding
CO538_RS03670	COG1494	fructose-1,6-bisphosphatase
CO538_RS03685	COG3842	ATPase activity
CO538_RS03690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CO538_RS03700	COG3932	Exopolysaccharide synthesis, ExoD
CO538_RS03705	COG0215	cysteine-tRNA ligase activity
CO538_RS03725	COG0109	protoheme IX farnesyltransferase activity
CO538_RS03730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CO538_RS03735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CO538_RS03740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO538_RS03745	COG1981	membrane
CO538_RS03750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CO538_RS03755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO538_RS03770	COG4974	Belongs to the 'phage' integrase family
CO538_RS03785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CO538_RS03795	COG0525	valine-tRNA ligase activity
CO538_RS03810	COG0284	orotidine-5'-phosphate decarboxylase activity
CO538_RS03825	COG2801	Transposase and inactivated derivatives
CO538_RS03835	COG3344	reverse transcriptase
CO538_RS03855	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CO538_RS03870	COG2801	Transposase and inactivated derivatives
CO538_RS03880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CO538_RS03900	COG2801	Transposase and inactivated derivatives
CO538_RS03905	COG3344	reverse transcriptase
CO538_RS03915	COG2801	Transposase and inactivated derivatives
CO538_RS03930	COG0736	holo-[acyl-carrier-protein] synthase activity
CO538_RS03955	COG3344	reverse transcriptase
CO538_RS03980	COG2801	Transposase and inactivated derivatives
CO538_RS03995	COG1115	amino acid carrier protein
CO538_RS04005	COG2801	Transposase and inactivated derivatives
CO538_RS04010	COG0424	maF-like protein
CO538_RS04025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CO538_RS04035	COG2801	Transposase and inactivated derivatives
CO538_RS04040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CO538_RS04045	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CO538_RS04050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CO538_RS04075	COG2801	Transposase and inactivated derivatives
CO538_RS04085	COG2814	Major facilitator Superfamily
CO538_RS04100	COG3344	reverse transcriptase
CO538_RS04110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CO538_RS04115	COG3344	reverse transcriptase
CO538_RS04125	COG2801	Transposase and inactivated derivatives
CO538_RS04140	COG1674	ftsk spoiiie
CO538_RS04155	COG2801	Transposase and inactivated derivatives
CO538_RS04170	COG2801	Transposase and inactivated derivatives
CO538_RS04180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CO538_RS04185	COG0148	phosphopyruvate hydratase activity
CO538_RS04200	COG3346	SURF1 family
CO538_RS04230	COG2801	Transposase and inactivated derivatives
CO538_RS04240	COG0114	fumarate hydratase activity
CO538_RS04255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO538_RS04260	COG2801	Transposase and inactivated derivatives
CO538_RS04275	COG0484	heat shock protein binding
CO538_RS04290	COG0823	Involved in the tonB-independent uptake of proteins
CO538_RS04295	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO538_RS04300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO538_RS04305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CO538_RS04310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CO538_RS04330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CO538_RS04335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CO538_RS04345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CO538_RS04370	COG3344	reverse transcriptase
CO538_RS04395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CO538_RS04415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CO538_RS04425	COG0022	dehydrogenase e1 component
CO538_RS04425	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO538_RS04435	COG0681	Belongs to the peptidase S26 family
CO538_RS04450	COG0316	Belongs to the HesB IscA family
CO538_RS04455	COG0822	iron-sulfur transferase activity
CO538_RS04460	COG0552	protein localization to endoplasmic reticulum
CO538_RS04490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CO538_RS04495	COG0459	protein refolding
CO538_RS04505	COG2801	Transposase and inactivated derivatives
CO538_RS04510	COG3344	reverse transcriptase
CO538_RS04520	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CO538_RS04525	COG0477	Major facilitator Superfamily
CO538_RS04535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO538_RS04545	COG2801	Transposase and inactivated derivatives
CO538_RS04560	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CO538_RS04575	COG3736	Type IV secretory pathway, component VirB8
CO538_RS04600	COG0717	Belongs to the dCTP deaminase family
CO538_RS04605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO538_RS04620	COG0233	cytoplasmic translational termination
CO538_RS04625	COG0528	UMP kinase activity
CO538_RS04630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CO538_RS04635	COG0052	Belongs to the universal ribosomal protein uS2 family
CO538_RS04645	COG1862	Preprotein translocase
CO538_RS04670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CO538_RS04670	COG4451	ribulose bisphosphate carboxylase, small
CO538_RS04680	COG0504	CTP synthase activity
CO538_RS04690	COG0590	tRNA wobble adenosine to inosine editing
CO538_RS04700	COG4133	protoheme IX ABC transporter activity
CO538_RS04705	COG0018	arginyl-trna synthetase
CO538_RS04720	COG1132	(ABC) transporter
CO538_RS04730	COG2814	Major facilitator Superfamily
CO538_RS04765	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CO538_RS04775	COG0281	malic enzyme
CO538_RS04775	COG0280	phosphate acetyltransferase
CO538_RS04780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CO538_RS04795	COG0217	transcriptional regulatory protein
CO538_RS04800	COG0739	heme binding
CO538_RS04835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CO538_RS04835	COG0574	Belongs to the PEP-utilizing enzyme family
CO538_RS04840	COG2003	Belongs to the UPF0758 family
CO538_RS04930	COG2801	Transposase and inactivated derivatives
CO538_RS04950	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CO538_RS04950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CO538_RS04955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO538_RS04960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CO538_RS04965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO538_RS04970	COG0792	nuclease activity
CO538_RS04975	COG0203	ribosomal protein L17
CO538_RS04980	COG0202	RNA polymerase activity
CO538_RS04985	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CO538_RS04990	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CO538_RS04995	COG0563	adenylate kinase activity
CO538_RS05000	COG0201	protein transport
CO538_RS05005	COG0200	Binds to the 23S rRNA
CO538_RS05010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CO538_RS05015	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CO538_RS05020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CO538_RS05025	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CO538_RS05030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO538_RS05035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CO538_RS05040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CO538_RS05045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CO538_RS05055	COG0255	Belongs to the universal ribosomal protein uL29 family
CO538_RS05060	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CO538_RS05065	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CO538_RS05070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CO538_RS05075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CO538_RS05080	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CO538_RS05090	COG0088	Forms part of the polypeptide exit tunnel
CO538_RS05095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CO538_RS05100	COG0051	transcription antitermination factor activity, RNA binding
CO538_RS05105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CO538_RS05145	COG3344	reverse transcriptase
CO538_RS05160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CO538_RS05165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CO538_RS05175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CO538_RS05180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CO538_RS05190	COG1845	cytochrome c oxidase, subunit III
CO538_RS05195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CO538_RS05200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CO538_RS05205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CO538_RS05205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO538_RS05230	COG3344	reverse transcriptase
CO538_RS05245	COG0594	ribonuclease P activity
CO538_RS05250	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CO538_RS05255	COG0573	inorganic phosphate transmembrane transporter activity
CO538_RS05260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CO538_RS05265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CO538_RS05280	COG3344	reverse transcriptase
CO538_RS05300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CO538_RS05305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CO538_RS05315	COG0307	riboflavin synthase, alpha
CO538_RS05325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO538_RS05360	COG3344	reverse transcriptase
CO538_RS05370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO538_RS05370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO538_RS05375	COG0154	amidase activity
CO538_RS05380	COG0187	DNA topoisomerase II activity
CO538_RS05405	COG1183	phosphatidylcholine synthase activity
CO538_RS05410	COG1115	amino acid carrier protein
CO538_RS05415	COG1115	amino acid carrier protein
CO538_RS05420	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CO538_RS05430	COG1230	cation diffusion facilitator family transporter
CO538_RS05450	COG2801	Transposase and inactivated derivatives
CO538_RS05455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO538_RS05465	COG0322	excinuclease ABC activity
CO538_RS05470	COG0751	glycine-tRNA ligase activity
CO538_RS05475	COG0752	glycyl-tRNA synthetase alpha subunit
CO538_RS05495	COG2801	Transposase and inactivated derivatives
CO538_RS05500	COG0113	porphobilinogen synthase activity
CO538_RS05505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CO538_RS05510	COG1034	ATP synthesis coupled electron transport
CO538_RS05520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CO538_RS05535	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CO538_RS05540	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CO538_RS05550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CO538_RS05565	COG3344	reverse transcriptase
CO538_RS05580	COG0571	ribonuclease III activity
CO538_RS05585	COG0167	dihydroorotate dehydrogenase activity
CO538_RS05600	COG1830	Aldolase
CO538_RS05610	COG0542	response to heat
CO538_RS05615	COG0513	Belongs to the DEAD box helicase family
CO538_RS05620	COG1278	Cold shock
CO538_RS05625	COG0312	modulator of DNA gyrase
CO538_RS05630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CO538_RS05645	COG4591	ABC-type transport system involved in lipoprotein release permease component
CO538_RS05670	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CO538_RS05675	COG2009	succinate dehydrogenase
CO538_RS05700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO538_RS05705	COG1006	Multisubunit Na H antiporter MnhC subunit
CO538_RS05715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CO538_RS05715	COG2111	Na H antiporter
CO538_RS05730	COG1758	RNA polymerase activity
CO538_RS05740	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CO538_RS05760	COG0330	HflC and HflK could
CO538_RS05780	COG2801	Transposase and inactivated derivatives
CO538_RS05790	COG2801	Transposase and inactivated derivatives
CO538_RS05880	COG2801	Transposase and inactivated derivatives
CO538_RS05885	COG0149	triose-phosphate isomerase activity
CO538_RS05895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CO538_RS05905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CO538_RS05915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO538_RS05920	COG0228	four-way junction DNA binding
CO538_RS05925	COG0142	geranyltranstransferase activity
CO538_RS05930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CO538_RS05940	COG2801	Transposase and inactivated derivatives
CO538_RS05960	COG2801	Transposase and inactivated derivatives
CO538_RS05965	COG0567	Dehydrogenase, E1 component
CO538_RS05975	COG2801	Transposase and inactivated derivatives
CO538_RS06005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CO538_RS06025	COG2801	Transposase and inactivated derivatives
CO538_RS06040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CO538_RS06045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CO538_RS06065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CO538_RS06075	COG0612	Peptidase, M16
CO538_RS06080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CO538_RS06085	COG0196	riboflavin kinase activity
CO538_RS06100	COG0481	GTPase activity
CO538_RS06115	COG1253	flavin adenine dinucleotide binding
CO538_RS06120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CO538_RS06120	COG0519	Catalyzes the synthesis of GMP from XMP
CO538_RS06125	COG1450	Type ii and iii secretion system protein
CO538_RS06145	COG3344	reverse transcriptase
CO538_RS06155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CO538_RS06160	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CO538_RS06165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CO538_RS06185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CO538_RS06195	COG2801	Transposase and inactivated derivatives
CO538_RS06215	COG3344	reverse transcriptase
CO538_RS06230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CO538_RS06240	COG3344	reverse transcriptase
CO538_RS06250	COG2801	Transposase and inactivated derivatives
CO538_RS06265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CO538_RS06280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CO538_RS06285	COG1301	dicarboxylic acid transport
CO538_RS06290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CO538_RS06300	COG2801	Transposase and inactivated derivatives
CO538_RS06310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CO538_RS06320	COG2801	Transposase and inactivated derivatives
CO538_RS06335	COG2801	Transposase and inactivated derivatives
CO538_RS06345	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO538_RS06360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CO538_RS06365	COG0758	DNA mediated transformation
CO538_RS06375	COG2801	Transposase and inactivated derivatives
CO538_RS06385	COG0653	protein targeting
CO538_RS06405	COG1322	Protein conserved in bacteria
CO538_RS06410	COG1686	Belongs to the peptidase S11 family
CO538_RS06415	COG2003	Belongs to the UPF0758 family
CO538_RS06430	COG1138	Cytochrome C-type biogenesis protein
CO538_RS06440	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CO538_RS06450	COG3344	reverse transcriptase
CO538_RS06465	COG3344	reverse transcriptase
CO538_RS06475	COG2239	Acts as a magnesium transporter
CO538_RS06495	COG0564	pseudouridine synthase activity
CO538_RS06520	COG3344	reverse transcriptase
CO538_RS06535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CO538_RS06550	COG3344	reverse transcriptase
CO538_RS06575	COG0564	pseudouridine synthase activity
CO538_RS06595	COG2239	Acts as a magnesium transporter
CO538_RS06605	COG3344	reverse transcriptase
CO538_RS06670	COG2801	Transposase and inactivated derivatives
CO538_RS06685	COG2003	Belongs to the UPF0758 family
CO538_RS06705	COG3621	Patatin-like phospholipase
CO538_RS06715	COG2801	Transposase and inactivated derivatives
CO538_RS06735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CO538_RS06740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CO538_RS06745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CO538_RS06755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CO538_RS06770	COG0492	ferredoxin-NADP+ reductase activity
CO538_RS06790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CO538_RS06810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CO538_RS06815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CO538_RS06820	COG0336	Belongs to the RNA methyltransferase TrmD family
CO538_RS06825	COG0335	large ribosomal subunit rRNA binding
CO538_RS06830	COG0581	inorganic phosphate transmembrane transporter activity
CO538_RS06835	COG0047	phosphoribosylformylglycinamidine synthase activity
CO538_RS06840	COG2801	Transposase and inactivated derivatives
CO538_RS06845	COG0259	pyridoxamine-phosphate oxidase activity
CO538_RS06850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CO538_RS06885	COG0489	protein tyrosine kinase activity
CO538_RS06900	COG3344	reverse transcriptase
CO538_RS06915	COG2801	Transposase and inactivated derivatives
CO538_RS06935	COG0651	ATP synthesis coupled electron transport
CO538_RS06940	COG0772	Belongs to the SEDS family
CO538_RS06945	COG1104	cysteine desulfurase activity
CO538_RS06955	COG2801	Transposase and inactivated derivatives
CO538_RS06975	COG3344	reverse transcriptase
CO538_RS06985	COG2003	Belongs to the UPF0758 family
CO538_RS06990	COG1396	sequence-specific DNA binding
CO538_RS07005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CO538_RS07010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CO538_RS07030	COG1132	(ABC) transporter
CO538_RS07055	COG0697	spore germination
CO538_RS07080	COG0312	modulator of DNA gyrase
CO538_RS07085	COG0723	plastoquinol--plastocyanin reductase activity
CO538_RS07110	COG1268	BioY protein
CO538_RS07125	COG3344	reverse transcriptase
CO538_RS07140	COG1253	flavin adenine dinucleotide binding