locus-tag	class	description
IYZ83_RS00020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IYZ83_RS00050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IYZ83_RS00070	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IYZ83_RS00075	COG0217	transcriptional regulatory protein
IYZ83_RS00080	COG0739	heme binding
IYZ83_RS00120	COG3577	Aspartyl protease
IYZ83_RS00135	COG0590	tRNA wobble adenosine to inosine editing
IYZ83_RS00145	COG0504	CTP synthase activity
IYZ83_RS00155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IYZ83_RS00155	COG4451	ribulose bisphosphate carboxylase, small
IYZ83_RS00165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IYZ83_RS00175	COG2801	Transposase and inactivated derivatives
IYZ83_RS00195	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
IYZ83_RS00210	COG3736	Type IV secretory pathway, component VirB8
IYZ83_RS00235	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IYZ83_RS00240	COG0758	DNA mediated transformation
IYZ83_RS00255	COG2255	four-way junction helicase activity
IYZ83_RS00260	COG0632	four-way junction helicase activity
IYZ83_RS00265	COG3474	cytochrome
IYZ83_RS00285	COG0839	Belongs to the complex I subunit 6 family
IYZ83_RS00290	COG0713	ATP synthesis coupled electron transport
IYZ83_RS00295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IYZ83_RS00300	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IYZ83_RS00305	COG1007	ATP synthesis coupled electron transport
IYZ83_RS00320	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IYZ83_RS00320	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IYZ83_RS00325	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IYZ83_RS00365	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IYZ83_RS00370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IYZ83_RS00375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IYZ83_RS00380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IYZ83_RS00395	COG0492	ferredoxin-NADP+ reductase activity
IYZ83_RS00410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IYZ83_RS00425	COG0756	dUTP diphosphatase activity
IYZ83_RS00440	COG1758	RNA polymerase activity
IYZ83_RS00450	COG1320	monovalent cation:proton antiporter activity
IYZ83_RS00455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IYZ83_RS00455	COG2111	Na H antiporter
IYZ83_RS00465	COG1006	Multisubunit Na H antiporter MnhC subunit
IYZ83_RS00470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IYZ83_RS00485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IYZ83_RS00490	COG2205	protein histidine kinase activity
IYZ83_RS00500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IYZ83_RS00530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IYZ83_RS00540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IYZ83_RS00545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IYZ83_RS00565	COG1566	PFAM secretion protein HlyD family protein
IYZ83_RS00570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IYZ83_RS00580	COG0280	phosphate acetyltransferase
IYZ83_RS00580	COG0281	malic enzyme
IYZ83_RS00585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IYZ83_RS00600	COG1121	(ABC) transporter
IYZ83_RS00605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IYZ83_RS00655	COG0736	holo-[acyl-carrier-protein] synthase activity
IYZ83_RS00670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IYZ83_RS00675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IYZ83_RS00745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IYZ83_RS00750	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IYZ83_RS00795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IYZ83_RS00815	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IYZ83_RS00830	COG0330	HflC and HflK could
IYZ83_RS00855	COG0697	spore germination
IYZ83_RS00865	COG0628	permease
IYZ83_RS00875	COG4974	Belongs to the 'phage' integrase family
IYZ83_RS00885	COG0268	Binds directly to 16S ribosomal RNA
IYZ83_RS00890	COG0372	Belongs to the citrate synthase family
IYZ83_RS00910	COG2827	Endonuclease containing a URI domain
IYZ83_RS00935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IYZ83_RS00940	COG0477	Major facilitator Superfamily
IYZ83_RS00945	COG0564	pseudouridine synthase activity
IYZ83_RS00980	COG2239	Acts as a magnesium transporter
IYZ83_RS01010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IYZ83_RS01055	COG0284	orotidine-5'-phosphate decarboxylase activity
IYZ83_RS01070	COG0525	valine-tRNA ligase activity
IYZ83_RS01085	COG0142	geranyltranstransferase activity
IYZ83_RS01090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IYZ83_RS01095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IYZ83_RS01110	COG1268	BioY protein
IYZ83_RS01135	COG0723	plastoquinol--plastocyanin reductase activity
IYZ83_RS01165	COG4974	Belongs to the 'phage' integrase family
IYZ83_RS01170	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IYZ83_RS01175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IYZ83_RS01180	COG1981	membrane
IYZ83_RS01185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IYZ83_RS01190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IYZ83_RS01195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IYZ83_RS01200	COG0109	protoheme IX farnesyltransferase activity
IYZ83_RS01220	COG0215	cysteine-tRNA ligase activity
IYZ83_RS01225	COG3932	Exopolysaccharide synthesis, ExoD
IYZ83_RS01230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IYZ83_RS01235	COG3842	ATPase activity
IYZ83_RS01250	COG1494	fructose-1,6-bisphosphatase
IYZ83_RS01260	COG0012	GTP binding
IYZ83_RS01275	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IYZ83_RS01285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IYZ83_RS01315	COG2814	Major facilitator Superfamily
IYZ83_RS01320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IYZ83_RS01340	COG0617	tRNA 3'-terminal CCA addition
IYZ83_RS01345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IYZ83_RS01350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IYZ83_RS01355	COG0823	Involved in the tonB-independent uptake of proteins
IYZ83_RS01365	COG0484	heat shock protein binding
IYZ83_RS01375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IYZ83_RS01400	COG0564	pseudouridine synthase activity
IYZ83_RS01415	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IYZ83_RS01450	COG1862	Preprotein translocase
IYZ83_RS01460	COG0052	Belongs to the universal ribosomal protein uS2 family
IYZ83_RS01465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IYZ83_RS01470	COG0528	UMP kinase activity
IYZ83_RS01475	COG0233	cytoplasmic translational termination
IYZ83_RS01490	COG0424	maF-like protein
IYZ83_RS01520	COG0321	lipoyl(octanoyl) transferase activity
IYZ83_RS01535	COG0776	regulation of translation
IYZ83_RS01550	COG0495	leucyl-tRNA aminoacylation
IYZ83_RS01565	COG1115	amino acid carrier protein
IYZ83_RS01585	COG0459	protein refolding
IYZ83_RS01590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IYZ83_RS01600	COG0666	response to abiotic stimulus
IYZ83_RS01615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IYZ83_RS01630	COG1381	Involved in DNA repair and RecF pathway recombination
IYZ83_RS01645	COG2902	Dehydrogenase
IYZ83_RS01650	COG0542	response to heat
IYZ83_RS01670	COG1840	ABC-type Fe3 transport system, periplasmic component
IYZ83_RS01675	COG0540	Belongs to the ATCase OTCase family
IYZ83_RS01690	COG0194	GDP metabolic process
IYZ83_RS01700	COG1053	succinate dehydrogenase
IYZ83_RS01710	COG2171	N-acyltransferase activity
IYZ83_RS01735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IYZ83_RS01740	COG1530	ribonuclease E activity
IYZ83_RS01745	COG0443	Heat shock 70 kDa protein
IYZ83_RS01750	COG0271	Belongs to the BolA IbaG family
IYZ83_RS01755	COG0626	cystathionine gamma-synthase activity
IYZ83_RS01765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IYZ83_RS01775	COG0009	L-threonylcarbamoyladenylate synthase
IYZ83_RS01780	COG0470	DNA polymerase III
IYZ83_RS01800	COG0305	Participates in initiation and elongation during chromosome replication
IYZ83_RS01810	COG1714	RDD family
IYZ83_RS01840	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IYZ83_RS01845	COG1115	amino acid carrier protein
IYZ83_RS01870	COG0450	alkyl hydroperoxide reductase
IYZ83_RS01905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IYZ83_RS01910	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IYZ83_RS01910	COG2857	Cytochrome c1
IYZ83_RS01915	COG0556	nucleotide-excision repair
IYZ83_RS01930	COG0149	triose-phosphate isomerase activity
IYZ83_RS01935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IYZ83_RS01965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IYZ83_RS02025	COG0508	dehydrogenase complex catalyzes the overall conversion of
IYZ83_RS02045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IYZ83_RS02045	COG0519	Catalyzes the synthesis of GMP from XMP
IYZ83_RS02050	COG1253	flavin adenine dinucleotide binding
IYZ83_RS02085	COG0575	Belongs to the CDS family
IYZ83_RS02095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IYZ83_RS02165	COG1322	Protein conserved in bacteria
IYZ83_RS02170	COG1686	Belongs to the peptidase S11 family
IYZ83_RS02190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IYZ83_RS02195	COG1301	dicarboxylic acid transport
IYZ83_RS02205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IYZ83_RS02220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IYZ83_RS02230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IYZ83_RS02260	COG2009	succinate dehydrogenase
IYZ83_RS02265	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IYZ83_RS02310	COG0651	ATP synthesis coupled electron transport
IYZ83_RS02315	COG0772	Belongs to the SEDS family
IYZ83_RS02320	COG1104	cysteine desulfurase activity
IYZ83_RS02370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IYZ83_RS02380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IYZ83_RS02390	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IYZ83_RS02395	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IYZ83_RS02400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IYZ83_RS02445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IYZ83_RS02445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IYZ83_RS02465	COG0481	GTPase activity
IYZ83_RS02480	COG0196	riboflavin kinase activity
IYZ83_RS02485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IYZ83_RS02490	COG0612	Peptidase, M16
IYZ83_RS02500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IYZ83_RS02520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IYZ83_RS02525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IYZ83_RS02540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IYZ83_RS02550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IYZ83_RS02555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IYZ83_RS02560	COG1185	polyribonucleotide nucleotidyltransferase activity
IYZ83_RS02565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IYZ83_RS02580	COG0126	phosphoglycerate kinase activity
IYZ83_RS02585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IYZ83_RS02600	COG2076	Multidrug Resistance protein
IYZ83_RS02605	COG0436	Aminotransferase
IYZ83_RS02610	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IYZ83_RS02615	COG1253	flavin adenine dinucleotide binding
IYZ83_RS02630	COG0567	Dehydrogenase, E1 component
IYZ83_RS02635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IYZ83_RS02650	COG0508	dehydrogenase complex catalyzes the overall conversion of
IYZ83_RS02695	COG0124	histidyl-tRNA synthetase
IYZ83_RS02700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IYZ83_RS02720	COG0531	amino acid
IYZ83_RS02725	COG1113	amino acid transport
IYZ83_RS02735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IYZ83_RS02740	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IYZ83_RS02755	COG0477	Major facilitator Superfamily
IYZ83_RS02760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IYZ83_RS02770	COG0114	fumarate hydratase activity
IYZ83_RS02785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IYZ83_RS02790	COG0142	geranyltranstransferase activity
IYZ83_RS02795	COG0228	four-way junction DNA binding
IYZ83_RS02800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IYZ83_RS02815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IYZ83_RS02860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IYZ83_RS02890	COG1132	(ABC) transporter
IYZ83_RS02910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IYZ83_RS02915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IYZ83_RS02940	COG0187	DNA topoisomerase II activity
IYZ83_RS02945	COG0154	amidase activity
IYZ83_RS02950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IYZ83_RS02950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IYZ83_RS02960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IYZ83_RS02975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IYZ83_RS02980	COG0254	rRNA binding
IYZ83_RS02985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IYZ83_RS02990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IYZ83_RS03020	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IYZ83_RS03030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IYZ83_RS03045	COG0473	3-isopropylmalate dehydrogenase activity
IYZ83_RS03060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IYZ83_RS03070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IYZ83_RS03075	COG0085	RNA polymerase activity
IYZ83_RS03075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IYZ83_RS03085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IYZ83_RS03090	COG0081	regulation of translation
IYZ83_RS03095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IYZ83_RS03100	COG0250	Participates in transcription elongation, termination and antitermination
IYZ83_RS03125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IYZ83_RS03130	COG0049	tRNA binding
IYZ83_RS03135	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IYZ83_RS03160	COG0544	peptidyl-prolyl cis-trans isomerase activity
IYZ83_RS03165	COG0740	serine-type endopeptidase activity
IYZ83_RS03170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IYZ83_RS03175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IYZ83_RS03180	COG0768	penicillin binding
IYZ83_RS03185	COG0726	polysaccharide deacetylase
IYZ83_RS03190	COG2003	Belongs to the UPF0758 family
IYZ83_RS03210	COG0606	chelatase, subunit chli
IYZ83_RS03225	COG0752	glycyl-tRNA synthetase alpha subunit
IYZ83_RS03230	COG0751	glycine-tRNA ligase activity
IYZ83_RS03235	COG0322	excinuclease ABC activity
IYZ83_RS03245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IYZ83_RS03260	COG0745	RESPONSE REGULATOR receiver
IYZ83_RS03265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IYZ83_RS03285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IYZ83_RS03290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IYZ83_RS03310	COG2885	chlorophyll binding
IYZ83_RS03325	COG0482	sulfurtransferase activity
IYZ83_RS03340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IYZ83_RS03350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IYZ83_RS03355	COG0543	2 iron, 2 sulfur cluster binding
IYZ83_RS03355	COG0493	'glutamate synthase
IYZ83_RS03370	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IYZ83_RS03380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IYZ83_RS03410	COG0629	single-stranded DNA binding
IYZ83_RS03415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IYZ83_RS03420	COG1063	alcohol dehydrogenase
IYZ83_RS03430	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IYZ83_RS03435	COG0670	Belongs to the BI1 family
IYZ83_RS03440	COG1104	cysteine desulfurase activity
IYZ83_RS03445	COG2945	thiolester hydrolase activity
IYZ83_RS03455	COG0316	Belongs to the HesB IscA family
IYZ83_RS03460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IYZ83_RS03465	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IYZ83_RS03465	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IYZ83_RS03480	COG0666	response to abiotic stimulus
IYZ83_RS03495	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IYZ83_RS03500	COG0343	queuine tRNA-ribosyltransferase activity
IYZ83_RS03510	COG0612	Peptidase, M16
IYZ83_RS03515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IYZ83_RS03550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IYZ83_RS03570	COG1830	Aldolase
IYZ83_RS03585	COG0167	dihydroorotate dehydrogenase activity
IYZ83_RS03590	COG0571	ribonuclease III activity
IYZ83_RS03600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IYZ83_RS03610	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IYZ83_RS03615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IYZ83_RS03630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IYZ83_RS03645	COG1034	ATP synthesis coupled electron transport
IYZ83_RS03650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IYZ83_RS03655	COG0113	porphobilinogen synthase activity
IYZ83_RS03665	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IYZ83_RS03675	COG3451	type IV secretory pathway VirB4
IYZ83_RS03680	COG3704	protein secretion by the type IV secretion system
IYZ83_RS03685	COG3704	protein secretion by the type IV secretion system
IYZ83_RS03705	COG0742	ribosomal rna small subunit methyltransferase
IYZ83_RS03715	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IYZ83_RS03720	COG3827	peptidoglycan binding
IYZ83_RS03730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IYZ83_RS03745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IYZ83_RS03750	COG0071	Belongs to the small heat shock protein (HSP20) family
IYZ83_RS03790	COG0045	succinate-CoA ligase (ADP-forming) activity
IYZ83_RS03805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IYZ83_RS03840	COG1475	DNA binding
IYZ83_RS03845	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IYZ83_RS03845	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IYZ83_RS03860	COG0326	Molecular chaperone. Has ATPase activity
IYZ83_RS03875	COG0156	8-amino-7-oxononanoate synthase activity
IYZ83_RS03885	COG0307	riboflavin synthase, alpha
IYZ83_RS03895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IYZ83_RS03905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IYZ83_RS03935	COG0445	tRNA wobble uridine modification
IYZ83_RS03995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IYZ83_RS04005	COG4770	biotin carboxylase activity
IYZ83_RS04010	COG1612	heme a metabolic process
IYZ83_RS04015	COG1215	transferase activity, transferring glycosyl groups
IYZ83_RS04030	COG1138	Cytochrome C-type biogenesis protein
IYZ83_RS04055	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IYZ83_RS04060	COG0356	it plays a direct role in the translocation of protons across the membrane
IYZ83_RS04070	COG0072	phenylalanine-tRNA ligase activity
IYZ83_RS04070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IYZ83_RS04080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IYZ83_RS04090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IYZ83_RS04095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IYZ83_RS04100	COG0649	NAD binding
IYZ83_RS04110	COG2070	2-Nitropropane dioxygenase
IYZ83_RS04125	COG3451	type IV secretory pathway VirB4
IYZ83_RS04145	COG0360	Binds together with S18 to 16S ribosomal RNA
IYZ83_RS04155	COG0359	binds to the 23S rRNA
IYZ83_RS04160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IYZ83_RS04180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IYZ83_RS04220	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IYZ83_RS04225	COG0163	prenyltransferase activity
IYZ83_RS04230	COG3750	Belongs to the UPF0335 family
IYZ83_RS04235	COG4536	flavin adenine dinucleotide binding
IYZ83_RS04240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IYZ83_RS04245	COG0105	UTP biosynthetic process
IYZ83_RS04255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IYZ83_RS04270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IYZ83_RS04275	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IYZ83_RS04285	COG1230	cation diffusion facilitator family transporter
IYZ83_RS04325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IYZ83_RS04325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IYZ83_RS04335	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IYZ83_RS04390	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IYZ83_RS04405	COG2094	Belongs to the DNA glycosylase MPG family
IYZ83_RS04420	COG1178	ABC-type Fe3 transport system permease component
IYZ83_RS04425	COG1054	Belongs to the UPF0176 family
IYZ83_RS04470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IYZ83_RS04490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IYZ83_RS04495	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IYZ83_RS04515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IYZ83_RS04540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IYZ83_RS04545	COG0259	pyridoxamine-phosphate oxidase activity
IYZ83_RS04555	COG0047	phosphoribosylformylglycinamidine synthase activity
IYZ83_RS04560	COG0581	inorganic phosphate transmembrane transporter activity
IYZ83_RS04565	COG0335	large ribosomal subunit rRNA binding
IYZ83_RS04570	COG0336	Belongs to the RNA methyltransferase TrmD family
IYZ83_RS04575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IYZ83_RS04580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IYZ83_RS04625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IYZ83_RS04630	COG0799	negative regulation of ribosome biogenesis
IYZ83_RS04640	COG0494	nUDIX hydrolase
IYZ83_RS04645	COG0084	hydrolase, TatD family'
IYZ83_RS04650	COG0039	L-malate dehydrogenase activity
IYZ83_RS04655	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IYZ83_RS04660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IYZ83_RS04665	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IYZ83_RS04670	COG0537	adenosine 5'-monophosphoramidase activity
IYZ83_RS04690	COG1090	epimerase
IYZ83_RS04700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IYZ83_RS04705	COG0416	fatty acid biosynthetic process
IYZ83_RS04710	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IYZ83_RS04715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IYZ83_RS04720	COG3842	ATPase activity
IYZ83_RS04725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IYZ83_RS04735	COG0493	'glutamate synthase
IYZ83_RS04735	COG0543	2 iron, 2 sulfur cluster binding
IYZ83_RS04755	COG0750	zinc metalloprotease
IYZ83_RS04770	COG0776	regulation of translation
IYZ83_RS04775	COG0539	negative regulation of cytoplasmic translation
IYZ83_RS04805	COG0312	modulator of DNA gyrase
IYZ83_RS04850	COG0653	protein targeting
IYZ83_RS04880	COG0285	dihydrofolate synthase activity
IYZ83_RS04895	COG2867	negative regulation of translational initiation
IYZ83_RS04930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IYZ83_RS04935	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IYZ83_RS04965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IYZ83_RS04970	COG0312	modulator of DNA gyrase
IYZ83_RS04975	COG1278	Cold shock
IYZ83_RS04980	COG0513	Belongs to the DEAD box helicase family
IYZ83_RS04990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IYZ83_RS04995	COG1028	Short-chain dehydrogenase reductase Sdr
IYZ83_RS05000	COG1295	ribonuclease BN
IYZ83_RS05020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IYZ83_RS05030	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IYZ83_RS05035	COG1573	uracil-dna glycosylase
IYZ83_RS05040	COG0242	peptide deformylase activity
IYZ83_RS05045	COG0849	cell division
IYZ83_RS05060	COG0275	rRNA processing
IYZ83_RS05070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IYZ83_RS05080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IYZ83_RS05085	COG0101	tRNA pseudouridine synthase activity
IYZ83_RS05100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IYZ83_RS05125	COG0552	protein localization to endoplasmic reticulum
IYZ83_RS05130	COG0822	iron-sulfur transferase activity
IYZ83_RS05135	COG0316	Belongs to the HesB IscA family
IYZ83_RS05150	COG0681	Belongs to the peptidase S26 family
IYZ83_RS05160	COG0508	dehydrogenase complex catalyzes the overall conversion of
IYZ83_RS05160	COG0022	dehydrogenase e1 component
IYZ83_RS05175	COG1183	phosphatidylcholine synthase activity
IYZ83_RS05185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IYZ83_RS05185	COG0574	Belongs to the PEP-utilizing enzyme family
IYZ83_RS05205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IYZ83_RS05205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IYZ83_RS05210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IYZ83_RS05215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IYZ83_RS05220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IYZ83_RS05225	COG0792	nuclease activity
IYZ83_RS05230	COG0203	ribosomal protein L17
IYZ83_RS05235	COG0202	RNA polymerase activity
IYZ83_RS05240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IYZ83_RS05245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IYZ83_RS05250	COG0563	adenylate kinase activity
IYZ83_RS05255	COG0201	protein transport
IYZ83_RS05260	COG0200	Binds to the 23S rRNA
IYZ83_RS05265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IYZ83_RS05270	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IYZ83_RS05275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IYZ83_RS05280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IYZ83_RS05285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IYZ83_RS05290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IYZ83_RS05295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IYZ83_RS05300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IYZ83_RS05310	COG0255	Belongs to the universal ribosomal protein uL29 family
IYZ83_RS05315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IYZ83_RS05320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IYZ83_RS05325	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IYZ83_RS05330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IYZ83_RS05335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IYZ83_RS05345	COG0088	Forms part of the polypeptide exit tunnel
IYZ83_RS05350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IYZ83_RS05355	COG0051	transcription antitermination factor activity, RNA binding
IYZ83_RS05390	COG3346	SURF1 family
IYZ83_RS05405	COG0148	phosphopyruvate hydratase activity
IYZ83_RS05410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IYZ83_RS05460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IYZ83_RS05465	COG0484	heat shock protein binding
IYZ83_RS05475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IYZ83_RS05480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IYZ83_RS05505	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IYZ83_RS05510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IYZ83_RS05520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IYZ83_RS05530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IYZ83_RS05535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IYZ83_RS05545	COG1845	cytochrome c oxidase, subunit III
IYZ83_RS05550	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IYZ83_RS05565	COG0594	ribonuclease P activity
IYZ83_RS05570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IYZ83_RS05575	COG0573	inorganic phosphate transmembrane transporter activity
IYZ83_RS05580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IYZ83_RS05585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IYZ83_RS05600	COG1132	(ABC) transporter
IYZ83_RS05615	COG0018	arginyl-trna synthetase
IYZ83_RS05620	COG4133	protoheme IX ABC transporter activity
IYZ83_RS05640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IYZ83_RS05650	COG0717	Belongs to the dCTP deaminase family
IYZ83_RS05660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IYZ83_RS05665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IYZ83_RS05670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IYZ83_RS05690	COG0235	Class ii aldolase
IYZ83_RS05710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IYZ83_RS05715	COG0358	DNA primase activity
IYZ83_RS05735	COG3088	subunit of a heme lyase
IYZ83_RS05740	COG1074	ATP-dependent DNA helicase activity
IYZ83_RS05755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IYZ83_RS05780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IYZ83_RS05785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IYZ83_RS05790	COG1217	gtp-binding protein TYPA
IYZ83_RS05795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IYZ83_RS05795	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IYZ83_RS05825	COG0805	protein transport
IYZ83_RS05840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IYZ83_RS05860	COG1181	Belongs to the D-alanine--D-alanine ligase family
IYZ83_RS05870	COG0653	protein targeting
IYZ83_RS05910	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IYZ83_RS05915	COG0237	dephospho-CoA kinase activity
IYZ83_RS05930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IYZ83_RS05940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IYZ83_RS05945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IYZ83_RS05955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IYZ83_RS05965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IYZ83_RS05970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family