locus-tag	class	description
E0495_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E0495_RS00025	COG3736	Type IV secretory pathway, component VirB8
E0495_RS00040	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
E0495_RS00045	COG3505	Type IV secretory pathway VirD4
E0495_RS00055	COG2890	protein-(glutamine-N5) methyltransferase activity
E0495_RS00080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E0495_RS00095	COG0250	Participates in transcription elongation, termination and antitermination
E0495_RS00100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E0495_RS00105	COG0081	regulation of translation
E0495_RS00110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E0495_RS00115	COG0222	ribosome binding
E0495_RS00120	COG0085	RNA polymerase activity
E0495_RS00120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E0495_RS00125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E0495_RS00135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E0495_RS00165	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E0495_RS00235	COG0307	riboflavin synthase, alpha
E0495_RS00250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E0495_RS00260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E0495_RS00270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E0495_RS00290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E0495_RS00305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E0495_RS00315	COG0187	DNA topoisomerase II activity
E0495_RS00345	COG2171	N-acyltransferase activity
E0495_RS00355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E0495_RS00365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0495_RS00365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0495_RS00370	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E0495_RS00375	COG0316	Belongs to the HesB IscA family
E0495_RS00390	COG2945	thiolester hydrolase activity
E0495_RS00395	COG1104	cysteine desulfurase activity
E0495_RS00405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E0495_RS00410	COG3547	Transposase (IS116 IS110 IS902 family)
E0495_RS00430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E0495_RS00440	COG0574	Belongs to the PEP-utilizing enzyme family
E0495_RS00440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E0495_RS00450	COG1494	fructose-1,6-bisphosphatase
E0495_RS00465	COG0505	Belongs to the CarA family
E0495_RS00480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E0495_RS00490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E0495_RS00505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E0495_RS00520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E0495_RS00555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E0495_RS00565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E0495_RS00575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E0495_RS00585	COG0201	protein transport
E0495_RS00595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E0495_RS00605	COG0202	RNA polymerase activity
E0495_RS00615	COG0792	nuclease activity
E0495_RS00620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E0495_RS00630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0495_RS00655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0495_RS00680	COG0358	DNA primase activity
E0495_RS00690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E0495_RS00700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0495_RS00710	COG0305	Participates in initiation and elongation during chromosome replication
E0495_RS00720	COG1714	RDD family
E0495_RS00730	COG2003	Belongs to the UPF0758 family
E0495_RS00740	COG1074	ATP-dependent DNA helicase activity
E0495_RS00755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E0495_RS00780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E0495_RS00810	COG1115	amino acid carrier protein
E0495_RS00850	COG4133	protoheme IX ABC transporter activity
E0495_RS00865	COG0477	Major facilitator Superfamily
E0495_RS00870	COG0564	pseudouridine synthase activity
E0495_RS00875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E0495_RS00880	COG1981	membrane
E0495_RS00890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E0495_RS00900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E0495_RS00910	COG0072	phenylalanine-tRNA ligase activity
E0495_RS00910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0495_RS00925	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E0495_RS00950	COG4770	biotin carboxylase activity
E0495_RS00960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0495_RS00965	COG1053	succinate dehydrogenase
E0495_RS00975	COG0194	GDP metabolic process
E0495_RS00990	COG0012	GTP binding
E0495_RS01000	COG0617	tRNA 3'-terminal CCA addition
E0495_RS01020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E0495_RS01025	COG0805	protein transport
E0495_RS01030	COG1438	arginine binding
E0495_RS01035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0495_RS01040	COG0765	amino acid transport
E0495_RS01045	COG1126	abc transporter atp-binding protein
E0495_RS01075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E0495_RS01110	COG0493	'glutamate synthase
E0495_RS01110	COG0543	2 iron, 2 sulfur cluster binding
E0495_RS01115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0495_RS01125	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E0495_RS01140	COG3328	transposase activity
E0495_RS01145	COG0697	spore germination
E0495_RS01170	COG1132	(ABC) transporter
E0495_RS01210	COG0653	protein targeting
E0495_RS01245	COG0163	prenyltransferase activity
E0495_RS01250	COG3750	Belongs to the UPF0335 family
E0495_RS01255	COG4536	flavin adenine dinucleotide binding
E0495_RS01260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E0495_RS01265	COG0649	NAD binding
E0495_RS01340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E0495_RS01345	COG0154	amidase activity
E0495_RS01385	COG0284	orotidine-5'-phosphate decarboxylase activity
E0495_RS01410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0495_RS01415	COG0525	valine-tRNA ligase activity
E0495_RS01440	COG0504	CTP synthase activity
E0495_RS01445	COG0590	tRNA wobble adenosine to inosine editing
E0495_RS01455	COG0477	Major facilitator Superfamily
E0495_RS01465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0495_RS01470	COG0022	dehydrogenase e1 component
E0495_RS01470	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0495_RS01505	COG0739	heme binding
E0495_RS01515	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0495_RS01525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E0495_RS01530	COG0280	phosphate acetyltransferase
E0495_RS01530	COG0281	malic enzyme
E0495_RS01550	COG0114	fumarate hydratase activity
E0495_RS01570	COG0018	arginyl-trna synthetase
E0495_RS01580	COG1132	(ABC) transporter
E0495_RS01620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E0495_RS01645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E0495_RS01675	COG1862	Preprotein translocase
E0495_RS01685	COG0052	Belongs to the universal ribosomal protein uS2 family
E0495_RS01695	COG0528	UMP kinase activity
E0495_RS01700	COG0233	cytoplasmic translational termination
E0495_RS01710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E0495_RS01715	COG0575	Belongs to the CDS family
E0495_RS01725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E0495_RS01745	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E0495_RS01755	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0495_RS01875	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E0495_RS01940	COG3344	reverse transcriptase
E0495_RS02090	COG3621	Patatin-like phospholipase
E0495_RS02220	COG2003	Belongs to the UPF0758 family
E0495_RS02270	COG3344	reverse transcriptase
E0495_RS02335	COG1138	Cytochrome C-type biogenesis protein
E0495_RS02355	COG1301	dicarboxylic acid transport
E0495_RS02360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E0495_RS02365	COG1217	gtp-binding protein TYPA
E0495_RS02405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E0495_RS02410	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E0495_RS02415	COG0823	Involved in the tonB-independent uptake of proteins
E0495_RS02465	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E0495_RS02475	COG1845	cytochrome c oxidase, subunit III
E0495_RS02485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E0495_RS02490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E0495_RS02520	COG3932	Exopolysaccharide synthesis, ExoD
E0495_RS02525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E0495_RS02530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E0495_RS02550	COG0752	glycyl-tRNA synthetase alpha subunit
E0495_RS02560	COG0113	porphobilinogen synthase activity
E0495_RS02565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E0495_RS02570	COG1034	ATP synthesis coupled electron transport
E0495_RS02585	COG1573	uracil-dna glycosylase
E0495_RS02590	COG0242	peptide deformylase activity
E0495_RS02600	COG0024	Methionine aminopeptidase
E0495_RS02605	COG0477	Major facilitator Superfamily
E0495_RS02640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0495_RS02665	COG0489	protein tyrosine kinase activity
E0495_RS02685	COG2801	Transposase and inactivated derivatives
E0495_RS02690	COG2801	Transposase and inactivated derivatives
E0495_RS02725	COG0666	response to abiotic stimulus
E0495_RS02735	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E0495_RS02740	COG3827	peptidoglycan binding
E0495_RS02765	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E0495_RS02780	COG2801	Transposase and inactivated derivatives
E0495_RS02790	COG0495	leucyl-tRNA aminoacylation
E0495_RS02805	COG0776	regulation of translation
E0495_RS02825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E0495_RS02875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0495_RS02905	COG0544	peptidyl-prolyl cis-trans isomerase activity
E0495_RS02915	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E0495_RS02920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E0495_RS02930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0495_RS02940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E0495_RS02945	COG0354	folic acid binding
E0495_RS02950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E0495_RS02955	COG0459	protein refolding
E0495_RS02980	COG0328	RNA-DNA hybrid ribonuclease activity
E0495_RS02985	COG0109	protoheme IX farnesyltransferase activity
E0495_RS02990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0495_RS02995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E0495_RS03005	COG2801	Transposase and inactivated derivatives
E0495_RS03020	COG3344	reverse transcriptase
E0495_RS03070	COG2814	Major facilitator Superfamily
E0495_RS03145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E0495_RS03165	COG2801	Transposase and inactivated derivatives
E0495_RS03175	COG2239	Acts as a magnesium transporter
E0495_RS03280	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E0495_RS03285	COG0552	protein localization to endoplasmic reticulum
E0495_RS03295	COG0316	Belongs to the HesB IscA family
E0495_RS03300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E0495_RS03305	COG0443	Heat shock 70 kDa protein
E0495_RS03310	COG0681	Belongs to the peptidase S26 family
E0495_RS03320	COG1840	ABC-type Fe3 transport system, periplasmic component
E0495_RS03345	COG0321	lipoyl(octanoyl) transferase activity
E0495_RS03360	COG4695	Portal protein
E0495_RS03390	COG0006	proline dipeptidase activity
E0495_RS03430	COG2801	Transposase and inactivated derivatives
E0495_RS03440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0495_RS03440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0495_RS03480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E0495_RS03485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E0495_RS03490	COG0573	inorganic phosphate transmembrane transporter activity
E0495_RS03525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E0495_RS03525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E0495_RS03535	COG1253	flavin adenine dinucleotide binding
E0495_RS03565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E0495_RS03575	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E0495_RS03580	COG0237	dephospho-CoA kinase activity
E0495_RS03590	COG2801	Transposase and inactivated derivatives
E0495_RS03595	COG2801	Transposase and inactivated derivatives
E0495_RS03620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E0495_RS03625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E0495_RS03630	COG2801	Transposase and inactivated derivatives
E0495_RS03650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E0495_RS03660	COG0149	triose-phosphate isomerase activity
E0495_RS03665	COG0758	DNA mediated transformation
E0495_RS03670	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E0495_RS03685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E0495_RS03690	COG1686	Belongs to the peptidase S11 family
E0495_RS03720	COG0768	penicillin binding
E0495_RS03730	COG0606	chelatase, subunit chli
E0495_RS03760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E0495_RS03775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E0495_RS03780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E0495_RS03785	COG0745	RESPONSE REGULATOR receiver
E0495_RS03815	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E0495_RS03820	COG0343	queuine tRNA-ribosyltransferase activity
E0495_RS03830	COG0612	Peptidase, M16
E0495_RS03835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E0495_RS03840	COG1271	oxidase subunit
E0495_RS03845	COG1294	oxidase, subunit
E0495_RS03850	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E0495_RS03870	COG0542	response to heat
E0495_RS03875	COG2902	Dehydrogenase
E0495_RS03935	COG0235	Class ii aldolase
E0495_RS03960	COG0312	modulator of DNA gyrase
E0495_RS03965	COG1104	cysteine desulfurase activity
E0495_RS03990	COG0527	aspartate kinase activity
E0495_RS04000	COG0531	amino acid
E0495_RS04020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E0495_RS04030	COG1127	ABC transporter
E0495_RS04035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E0495_RS04040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E0495_RS04050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E0495_RS04055	COG0492	ferredoxin-NADP+ reductase activity
E0495_RS04070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0495_RS04075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E0495_RS04085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E0495_RS04090	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E0495_RS04160	COG4974	Belongs to the 'phage' integrase family
E0495_RS04175	COG0450	alkyl hydroperoxide reductase
E0495_RS04190	COG0196	riboflavin kinase activity
E0495_RS04195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E0495_RS04200	COG0612	Peptidase, M16
E0495_RS04210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E0495_RS04270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0495_RS04280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0495_RS04295	COG0360	Binds together with S18 to 16S ribosomal RNA
E0495_RS04310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E0495_RS04335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E0495_RS04340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E0495_RS04350	COG0473	3-isopropylmalate dehydrogenase activity
E0495_RS04420	COG0326	Molecular chaperone. Has ATPase activity
E0495_RS04430	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E0495_RS04445	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E0495_RS04475	COG0756	dUTP diphosphatase activity
E0495_RS04480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E0495_RS04485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E0495_RS04490	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E0495_RS04540	COG2009	succinate dehydrogenase
E0495_RS04545	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E0495_RS04575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E0495_RS04580	COG0312	modulator of DNA gyrase
E0495_RS04585	COG1278	Cold shock
E0495_RS04590	COG0513	Belongs to the DEAD box helicase family
E0495_RS04600	COG1830	Aldolase
E0495_RS04610	COG0167	dihydroorotate dehydrogenase activity
E0495_RS04640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E0495_RS04645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E0495_RS04645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E0495_RS04655	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
E0495_RS04700	COG2801	Transposase and inactivated derivatives
E0495_RS04705	COG2801	Transposase and inactivated derivatives
E0495_RS04730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E0495_RS04735	COG0254	rRNA binding
E0495_RS04740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E0495_RS04745	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E0495_RS04785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E0495_RS04800	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E0495_RS04810	COG3451	type IV secretory pathway VirB4
E0495_RS04815	COG3704	protein secretion by the type IV secretion system
E0495_RS04820	COG3704	protein secretion by the type IV secretion system
E0495_RS04825	COG3704	protein secretion by the type IV secretion system
E0495_RS04840	COG0742	ribosomal rna small subunit methyltransferase
E0495_RS04855	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E0495_RS04870	COG4235	cytochrome complex assembly
E0495_RS04870	COG3088	subunit of a heme lyase
E0495_RS04900	COG0556	nucleotide-excision repair
E0495_RS04920	COG3577	Aspartyl protease
E0495_RS04955	COG1475	DNA binding
E0495_RS04985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E0495_RS05000	COG0045	succinate-CoA ligase (ADP-forming) activity
E0495_RS05015	COG0778	Nitroreductase
E0495_RS05020	COG1268	BioY protein
E0495_RS05050	COG0723	plastoquinol--plastocyanin reductase activity
E0495_RS05065	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E0495_RS05080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0495_RS05085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0495_RS05090	COG0142	geranyltranstransferase activity
E0495_RS05100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E0495_RS05130	COG0105	UTP biosynthetic process
E0495_RS05140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E0495_RS05155	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0495_RS05175	COG3451	type IV secretory pathway VirB4
E0495_RS05190	COG2070	2-Nitropropane dioxygenase
E0495_RS05200	COG0126	phosphoglycerate kinase activity
E0495_RS05215	COG0564	pseudouridine synthase activity
E0495_RS05225	COG0658	competence protein
E0495_RS05225	COG2333	competence protein COMEC
E0495_RS05235	COG0259	pyridoxamine-phosphate oxidase activity
E0495_RS05240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E0495_RS05250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E0495_RS05270	COG1160	GTP binding
E0495_RS05280	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E0495_RS05300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E0495_RS05325	COG0651	ATP synthesis coupled electron transport
E0495_RS05330	COG0772	Belongs to the SEDS family
E0495_RS05335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E0495_RS05340	COG2094	Belongs to the DNA glycosylase MPG family
E0495_RS05380	COG0084	hydrolase, TatD family'
E0495_RS05390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0495_RS05400	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0495_RS05455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E0495_RS05460	COG1054	Belongs to the UPF0176 family
E0495_RS05465	COG1178	ABC-type Fe3 transport system permease component
E0495_RS05495	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E0495_RS05505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E0495_RS05505	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E0495_RS05510	COG0628	permease
E0495_RS05520	COG4974	Belongs to the 'phage' integrase family
E0495_RS05535	COG0372	Belongs to the citrate synthase family
E0495_RS05575	COG2801	Transposase and inactivated derivatives
E0495_RS05580	COG1322	Protein conserved in bacteria
E0495_RS05650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E0495_RS05660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0495_RS05670	COG2885	chlorophyll binding
E0495_RS05740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E0495_RS05750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0495_RS05755	COG0670	Belongs to the BI1 family
E0495_RS05760	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E0495_RS05800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E0495_RS05805	COG1121	(ABC) transporter
E0495_RS05820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E0495_RS05825	COG1530	ribonuclease E activity
E0495_RS05840	COG0626	cystathionine gamma-synthase activity
E0495_RS05860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E0495_RS05870	COG1185	polyribonucleotide nucleotidyltransferase activity
E0495_RS05935	COG0330	HflC and HflK could
E0495_RS05975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E0495_RS05995	COG0047	phosphoribosylformylglycinamidine synthase activity
E0495_RS06020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E0495_RS06025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E0495_RS06050	COG1253	flavin adenine dinucleotide binding
E0495_RS06060	COG0436	Aminotransferase
E0495_RS06085	COG0477	Major facilitator Superfamily
E0495_RS06095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E0495_RS06120	COG1230	cation diffusion facilitator family transporter
E0495_RS06130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E0495_RS06135	COG1115	amino acid carrier protein
E0495_RS06140	COG1115	amino acid carrier protein
E0495_RS06145	COG1183	phosphatidylcholine synthase activity
E0495_RS06155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E0495_RS06170	COG0156	8-amino-7-oxononanoate synthase activity
E0495_RS06180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E0495_RS06190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E0495_RS06195	COG2202	Pas domain
E0495_RS06195	COG2205	protein histidine kinase activity
E0495_RS06200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E0495_RS06205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E0495_RS06230	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E0495_RS06250	COG0142	geranyltranstransferase activity
E0495_RS06270	COG3474	cytochrome
E0495_RS06290	COG0442	prolyl-tRNA aminoacylation
E0495_RS06295	COG0736	holo-[acyl-carrier-protein] synthase activity
E0495_RS06325	COG0009	L-threonylcarbamoyladenylate synthase
E0495_RS06425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E0495_RS06480	COG0839	Belongs to the complex I subunit 6 family
E0495_RS06485	COG0713	ATP synthesis coupled electron transport
E0495_RS06490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E0495_RS06495	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0495_RS06500	COG1007	ATP synthesis coupled electron transport
E0495_RS06505	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E0495_RS06505	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E0495_RS06510	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E0495_RS06570	COG0285	dihydrofolate synthase activity
E0495_RS06585	COG2867	negative regulation of translational initiation
E0495_RS06620	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E0495_RS06625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E0495_RS06635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E0495_RS06650	COG0101	tRNA pseudouridine synthase activity
E0495_RS06665	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E0495_RS06665	COG2857	Cytochrome c1
E0495_RS06670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E0495_RS06685	COG0484	heat shock protein binding
E0495_RS06705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E0495_RS06715	COG0543	2 iron, 2 sulfur cluster binding
E0495_RS06715	COG0493	'glutamate synthase
E0495_RS06735	COG0750	zinc metalloprotease
E0495_RS06750	COG0776	regulation of translation
E0495_RS06755	COG0539	negative regulation of cytoplasmic translation
E0495_RS06760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E0495_RS06800	COG1295	ribonuclease BN
E0495_RS06805	COG1028	Short-chain dehydrogenase reductase Sdr
E0495_RS06815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E0495_RS06830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E0495_RS06835	COG1006	Multisubunit Na H antiporter MnhC subunit
E0495_RS06845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E0495_RS06845	COG2111	Na H antiporter
E0495_RS06870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E0495_RS06880	COG0567	Dehydrogenase, E1 component
E0495_RS06905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E0495_RS06910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E0495_RS06915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E0495_RS06920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E0495_RS06930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0495_RS06940	COG0174	glutamine synthetase