locus-tag	class	description
FRT63_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FRT63_RS00025	COG3736	Type IV secretory pathway, component VirB8
FRT63_RS00040	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FRT63_RS00045	COG3505	Type IV secretory pathway VirD4
FRT63_RS00055	COG2890	protein-(glutamine-N5) methyltransferase activity
FRT63_RS00060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRT63_RS00075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRT63_RS00090	COG0250	Participates in transcription elongation, termination and antitermination
FRT63_RS00095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FRT63_RS00100	COG0081	regulation of translation
FRT63_RS00105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FRT63_RS00110	COG0222	ribosome binding
FRT63_RS00115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FRT63_RS00115	COG0085	RNA polymerase activity
FRT63_RS00120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRT63_RS00130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FRT63_RS00160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRT63_RS00165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRT63_RS00170	COG0823	Involved in the tonB-independent uptake of proteins
FRT63_RS00180	COG0484	heat shock protein binding
FRT63_RS00245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FRT63_RS00255	COG0776	regulation of translation
FRT63_RS00270	COG0495	leucyl-tRNA aminoacylation
FRT63_RS00280	COG2801	Transposase and inactivated derivatives
FRT63_RS00295	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FRT63_RS00310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FRT63_RS00320	COG3827	peptidoglycan binding
FRT63_RS00325	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FRT63_RS00365	COG2801	Transposase and inactivated derivatives
FRT63_RS00390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FRT63_RS00395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRT63_RS00400	COG2801	Transposase and inactivated derivatives
FRT63_RS00420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRT63_RS00430	COG0149	triose-phosphate isomerase activity
FRT63_RS00435	COG0758	DNA mediated transformation
FRT63_RS00440	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FRT63_RS00455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FRT63_RS00460	COG1686	Belongs to the peptidase S11 family
FRT63_RS00485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FRT63_RS00500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRT63_RS00515	COG0187	DNA topoisomerase II activity
FRT63_RS00540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FRT63_RS00555	COG1674	ftsk spoiiie
FRT63_RS00610	COG0307	riboflavin synthase, alpha
FRT63_RS00620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FRT63_RS00625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRT63_RS00635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FRT63_RS00640	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FRT63_RS00650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FRT63_RS00665	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRT63_RS00675	COG1845	cytochrome c oxidase, subunit III
FRT63_RS00680	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FRT63_RS00685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRT63_RS00695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRT63_RS00710	COG0215	cysteine-tRNA ligase activity
FRT63_RS00715	COG3932	Exopolysaccharide synthesis, ExoD
FRT63_RS00725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRT63_RS00730	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FRT63_RS00740	COG0322	excinuclease ABC activity
FRT63_RS00750	COG0752	glycyl-tRNA synthetase alpha subunit
FRT63_RS00760	COG0113	porphobilinogen synthase activity
FRT63_RS00765	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FRT63_RS00790	COG1573	uracil-dna glycosylase
FRT63_RS00795	COG0242	peptide deformylase activity
FRT63_RS00800	COG0849	cell division
FRT63_RS00805	COG0024	Methionine aminopeptidase
FRT63_RS00810	COG0477	Major facilitator Superfamily
FRT63_RS00815	COG0275	rRNA processing
FRT63_RS00835	COG0193	aminoacyl-tRNA hydrolase activity
FRT63_RS00850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRT63_RS00885	COG2801	Transposase and inactivated derivatives
FRT63_RS00900	COG0237	dephospho-CoA kinase activity
FRT63_RS00905	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FRT63_RS00915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRT63_RS00930	COG1253	flavin adenine dinucleotide binding
FRT63_RS00940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FRT63_RS00940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRT63_RS00975	COG0573	inorganic phosphate transmembrane transporter activity
FRT63_RS00980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FRT63_RS00985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FRT63_RS00995	COG2801	Transposase and inactivated derivatives
FRT63_RS01010	COG0235	Class ii aldolase
FRT63_RS01050	COG4804	nuclease activity
FRT63_RS01055	COG1381	Involved in DNA repair and RecF pathway recombination
FRT63_RS01070	COG2902	Dehydrogenase
FRT63_RS01075	COG0542	response to heat
FRT63_RS01090	COG1217	gtp-binding protein TYPA
FRT63_RS01095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FRT63_RS01100	COG1823	symporter activity
FRT63_RS01115	COG1138	Cytochrome C-type biogenesis protein
FRT63_RS01135	COG3577	Aspartyl protease
FRT63_RS01170	COG0756	dUTP diphosphatase activity
FRT63_RS01175	COG0525	valine-tRNA ligase activity
FRT63_RS01180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FRT63_RS01185	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FRT63_RS01190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FRT63_RS01195	COG2814	Major facilitator Superfamily
FRT63_RS01220	COG2801	Transposase and inactivated derivatives
FRT63_RS01225	COG1322	Protein conserved in bacteria
FRT63_RS01235	COG3328	transposase activity
FRT63_RS01285	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FRT63_RS01445	COG2963	transposase activity
FRT63_RS01455	COG2801	Transposase and inactivated derivatives
FRT63_RS01460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FRT63_RS01465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRT63_RS01470	COG0109	protoheme IX farnesyltransferase activity
FRT63_RS01475	COG0328	RNA-DNA hybrid ribonuclease activity
FRT63_RS01485	COG0459	protein refolding
FRT63_RS01490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FRT63_RS01495	COG0354	folic acid binding
FRT63_RS01500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRT63_RS01520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRT63_RS01530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FRT63_RS01535	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FRT63_RS01540	COG0740	serine-type endopeptidase activity
FRT63_RS01545	COG0544	peptidyl-prolyl cis-trans isomerase activity
FRT63_RS01575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRT63_RS01615	COG1115	amino acid carrier protein
FRT63_RS01625	COG0424	maF-like protein
FRT63_RS01645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FRT63_RS01660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FRT63_RS01690	COG2801	Transposase and inactivated derivatives
FRT63_RS01695	COG2801	Transposase and inactivated derivatives
FRT63_RS01710	COG0358	DNA primase activity
FRT63_RS01720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRT63_RS01730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRT63_RS01740	COG0305	Participates in initiation and elongation during chromosome replication
FRT63_RS01750	COG1714	RDD family
FRT63_RS01755	COG2003	Belongs to the UPF0758 family
FRT63_RS01765	COG1074	ATP-dependent DNA helicase activity
FRT63_RS01770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FRT63_RS01780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FRT63_RS01805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FRT63_RS01825	COG2801	Transposase and inactivated derivatives
FRT63_RS01835	COG2239	Acts as a magnesium transporter
FRT63_RS01880	COG2814	Major facilitator Superfamily
FRT63_RS01895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FRT63_RS01920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FRT63_RS01925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRT63_RS01930	COG2226	methyltransferase
FRT63_RS01970	COG1132	(ABC) transporter
FRT63_RS01980	COG0018	arginyl-trna synthetase
FRT63_RS02005	COG4133	protoheme IX ABC transporter activity
FRT63_RS02015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FRT63_RS02020	COG0477	Major facilitator Superfamily
FRT63_RS02025	COG0564	pseudouridine synthase activity
FRT63_RS02030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FRT63_RS02035	COG1981	membrane
FRT63_RS02045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRT63_RS02055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FRT63_RS02065	COG0072	phenylalanine-tRNA ligase activity
FRT63_RS02065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRT63_RS02075	COG0356	it plays a direct role in the translocation of protons across the membrane
FRT63_RS02080	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRT63_RS02100	COG1612	heme a metabolic process
FRT63_RS02105	COG4770	biotin carboxylase activity
FRT63_RS02115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRT63_RS02125	COG1053	succinate dehydrogenase
FRT63_RS02135	COG0194	GDP metabolic process
FRT63_RS02155	COG0012	GTP binding
FRT63_RS02165	COG0617	tRNA 3'-terminal CCA addition
FRT63_RS02195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FRT63_RS02200	COG0805	protein transport
FRT63_RS02205	COG1438	arginine binding
FRT63_RS02210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRT63_RS02215	COG0765	amino acid transport
FRT63_RS02220	COG1126	abc transporter atp-binding protein
FRT63_RS02245	COG0284	orotidine-5'-phosphate decarboxylase activity
FRT63_RS02255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRT63_RS02260	COG0525	valine-tRNA ligase activity
FRT63_RS02280	COG0504	CTP synthase activity
FRT63_RS02285	COG0590	tRNA wobble adenosine to inosine editing
FRT63_RS02290	COG0477	Major facilitator Superfamily
FRT63_RS02300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRT63_RS02305	COG0022	dehydrogenase e1 component
FRT63_RS02305	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRT63_RS02315	COG0481	GTPase activity
FRT63_RS02345	COG0739	heme binding
FRT63_RS02350	COG0217	transcriptional regulatory protein
FRT63_RS02355	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRT63_RS02365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FRT63_RS02370	COG0281	malic enzyme
FRT63_RS02370	COG0280	phosphate acetyltransferase
FRT63_RS02390	COG0114	fumarate hydratase activity
FRT63_RS02395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FRT63_RS02400	COG0148	phosphopyruvate hydratase activity
FRT63_RS02405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRT63_RS02435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRT63_RS02440	COG0154	amidase activity
FRT63_RS02460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FRT63_RS02515	COG2963	transposase activity
FRT63_RS02525	COG2801	Transposase and inactivated derivatives
FRT63_RS02545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FRT63_RS02555	COG0575	Belongs to the CDS family
FRT63_RS02560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FRT63_RS02570	COG0233	cytoplasmic translational termination
FRT63_RS02575	COG0528	UMP kinase activity
FRT63_RS02580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FRT63_RS02585	COG0052	Belongs to the universal ribosomal protein uS2 family
FRT63_RS02595	COG1862	Preprotein translocase
FRT63_RS02630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FRT63_RS02640	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRT63_RS02665	COG0653	protein targeting
FRT63_RS02700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FRT63_RS02705	COG0163	prenyltransferase activity
FRT63_RS02710	COG3750	Belongs to the UPF0335 family
FRT63_RS02715	COG4536	flavin adenine dinucleotide binding
FRT63_RS02720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRT63_RS02725	COG0649	NAD binding
FRT63_RS02750	COG3621	Patatin-like phospholipase
FRT63_RS02885	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FRT63_RS02895	COG0666	response to abiotic stimulus
FRT63_RS02965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRT63_RS02970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRT63_RS02975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRT63_RS02995	COG1132	(ABC) transporter
FRT63_RS03020	COG0697	spore germination
FRT63_RS03040	COG2003	Belongs to the UPF0758 family
FRT63_RS03045	COG1396	sequence-specific DNA binding
FRT63_RS03155	COG2963	transposase activity
FRT63_RS03160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRT63_RS03185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRT63_RS03190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FRT63_RS03195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRT63_RS03200	COG0792	nuclease activity
FRT63_RS03210	COG0202	RNA polymerase activity
FRT63_RS03215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FRT63_RS03220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FRT63_RS03225	COG0563	adenylate kinase activity
FRT63_RS03230	COG0201	protein transport
FRT63_RS03240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FRT63_RS03250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FRT63_RS03260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FRT63_RS03285	COG0255	Belongs to the universal ribosomal protein uL29 family
FRT63_RS03295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FRT63_RS03310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FRT63_RS03320	COG0088	Forms part of the polypeptide exit tunnel
FRT63_RS03325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FRT63_RS03330	COG0051	transcription antitermination factor activity, RNA binding
FRT63_RS03335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRT63_RS03350	COG0505	Belongs to the CarA family
FRT63_RS03365	COG1494	fructose-1,6-bisphosphatase
FRT63_RS03375	COG0574	Belongs to the PEP-utilizing enzyme family
FRT63_RS03375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRT63_RS03390	COG3344	reverse transcriptase
FRT63_RS03400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRT63_RS03415	COG3547	Transposase (IS116 IS110 IS902 family)
FRT63_RS03420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FRT63_RS03430	COG1104	cysteine desulfurase activity
FRT63_RS03435	COG2945	thiolester hydrolase activity
FRT63_RS03450	COG0316	Belongs to the HesB IscA family
FRT63_RS03455	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FRT63_RS03460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRT63_RS03460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRT63_RS03470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRT63_RS03480	COG2171	N-acyltransferase activity
FRT63_RS03510	COG0768	penicillin binding
FRT63_RS03520	COG0606	chelatase, subunit chli
FRT63_RS03550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FRT63_RS03565	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FRT63_RS03570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FRT63_RS03575	COG0745	RESPONSE REGULATOR receiver
FRT63_RS03590	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FRT63_RS03595	COG0343	queuine tRNA-ribosyltransferase activity
FRT63_RS03605	COG0612	Peptidase, M16
FRT63_RS03610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FRT63_RS03620	COG1271	oxidase subunit
FRT63_RS03625	COG1294	oxidase, subunit
FRT63_RS03630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FRT63_RS03670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRT63_RS03675	COG4974	Belongs to the 'phage' integrase family
FRT63_RS03695	COG0450	alkyl hydroperoxide reductase
FRT63_RS03710	COG0196	riboflavin kinase activity
FRT63_RS03715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FRT63_RS03720	COG0612	Peptidase, M16
FRT63_RS03730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FRT63_RS03755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FRT63_RS03785	COG0629	single-stranded DNA binding
FRT63_RS03790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRT63_RS03795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FRT63_RS03800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRT63_RS03810	COG0360	Binds together with S18 to 16S ribosomal RNA
FRT63_RS03820	COG0359	binds to the 23S rRNA
FRT63_RS03835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FRT63_RS03850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRT63_RS03855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRT63_RS03865	COG0473	3-isopropylmalate dehydrogenase activity
FRT63_RS03880	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FRT63_RS03900	COG0142	geranyltranstransferase activity
FRT63_RS03905	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRT63_RS03920	COG3474	cytochrome
FRT63_RS03940	COG0442	prolyl-tRNA aminoacylation
FRT63_RS03945	COG0736	holo-[acyl-carrier-protein] synthase activity
FRT63_RS03975	COG0009	L-threonylcarbamoyladenylate synthase
FRT63_RS03985	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FRT63_RS03995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FRT63_RS04050	COG0330	HflC and HflK could
FRT63_RS04080	COG0556	nucleotide-excision repair
FRT63_RS04100	COG4235	cytochrome complex assembly
FRT63_RS04100	COG3088	subunit of a heme lyase
FRT63_RS04120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FRT63_RS04135	COG0742	ribosomal rna small subunit methyltransferase
FRT63_RS04150	COG1340	protein secretion by the type IV secretion system
FRT63_RS04150	COG3704	protein secretion by the type IV secretion system
FRT63_RS04155	COG3704	protein secretion by the type IV secretion system
FRT63_RS04160	COG3704	protein secretion by the type IV secretion system
FRT63_RS04165	COG3451	type IV secretory pathway VirB4
FRT63_RS04175	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FRT63_RS04190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FRT63_RS04205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FRT63_RS04210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FRT63_RS04230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FRT63_RS04235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FRT63_RS04240	COG0254	rRNA binding
FRT63_RS04245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRT63_RS04305	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FRT63_RS04335	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FRT63_RS04340	COG0552	protein localization to endoplasmic reticulum
FRT63_RS04345	COG0822	iron-sulfur transferase activity
FRT63_RS04350	COG0316	Belongs to the HesB IscA family
FRT63_RS04355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FRT63_RS04365	COG0681	Belongs to the peptidase S26 family
FRT63_RS04375	COG1840	ABC-type Fe3 transport system, periplasmic component
FRT63_RS04425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRT63_RS04430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FRT63_RS04435	COG1185	polyribonucleotide nucleotidyltransferase activity
FRT63_RS04470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRT63_RS04515	COG0626	cystathionine gamma-synthase activity
FRT63_RS04525	COG0443	Heat shock 70 kDa protein
FRT63_RS04530	COG1530	ribonuclease E activity
FRT63_RS04535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FRT63_RS04570	COG1121	(ABC) transporter
FRT63_RS04575	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRT63_RS04635	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FRT63_RS04640	COG0670	Belongs to the BI1 family
FRT63_RS04645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRT63_RS04655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FRT63_RS04675	COG0531	amino acid
FRT63_RS04690	COG0527	aspartate kinase activity
FRT63_RS04720	COG0839	Belongs to the complex I subunit 6 family
FRT63_RS04725	COG0713	ATP synthesis coupled electron transport
FRT63_RS04730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRT63_RS04735	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT63_RS04740	COG1007	ATP synthesis coupled electron transport
FRT63_RS04745	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FRT63_RS04745	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FRT63_RS04745	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FRT63_RS04745	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FRT63_RS04750	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FRT63_RS04780	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FRT63_RS04785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FRT63_RS04790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FRT63_RS04800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT63_RS04805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FRT63_RS04815	COG0492	ferredoxin-NADP+ reductase activity
FRT63_RS04825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRT63_RS04830	COG0416	fatty acid biosynthetic process
FRT63_RS04835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FRT63_RS04840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRT63_RS04845	COG1127	ABC transporter
FRT63_RS04855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FRT63_RS04870	COG3344	reverse transcriptase
FRT63_RS04880	COG1104	cysteine desulfurase activity
FRT63_RS04885	COG0312	modulator of DNA gyrase
FRT63_RS04915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRT63_RS04915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRT63_RS04920	COG2801	Transposase and inactivated derivatives
FRT63_RS04955	COG0445	tRNA wobble uridine modification
FRT63_RS04975	COG4695	Portal protein
FRT63_RS04990	COG0321	lipoyl(octanoyl) transferase activity
FRT63_RS05020	COG0047	phosphoribosylformylglycinamidine synthase activity
FRT63_RS05040	COG0336	Belongs to the RNA methyltransferase TrmD family
FRT63_RS05045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FRT63_RS05050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FRT63_RS05065	COG1253	flavin adenine dinucleotide binding
FRT63_RS05070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FRT63_RS05075	COG0436	Aminotransferase
FRT63_RS05100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FRT63_RS05120	COG1230	cation diffusion facilitator family transporter
FRT63_RS05130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FRT63_RS05135	COG1115	amino acid carrier protein
FRT63_RS05140	COG1115	amino acid carrier protein
FRT63_RS05145	COG1183	phosphatidylcholine synthase activity
FRT63_RS05155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FRT63_RS05160	COG0484	heat shock protein binding
FRT63_RS05165	COG0285	dihydrofolate synthase activity
FRT63_RS05180	COG2867	negative regulation of translational initiation
FRT63_RS05215	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FRT63_RS05220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FRT63_RS05230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRT63_RS05245	COG0101	tRNA pseudouridine synthase activity
FRT63_RS05260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRT63_RS05260	COG2857	Cytochrome c1
FRT63_RS05265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRT63_RS05280	COG0484	heat shock protein binding
FRT63_RS05290	COG0124	histidyl-tRNA synthetase
FRT63_RS05295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FRT63_RS05300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FRT63_RS05310	COG0543	2 iron, 2 sulfur cluster binding
FRT63_RS05310	COG0493	'glutamate synthase
FRT63_RS05315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FRT63_RS05330	COG0750	zinc metalloprotease
FRT63_RS05345	COG0776	regulation of translation
FRT63_RS05350	COG0539	negative regulation of cytoplasmic translation
FRT63_RS05355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FRT63_RS05380	COG1160	GTP binding
FRT63_RS05390	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FRT63_RS05395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRT63_RS05400	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRT63_RS05420	COG0651	ATP synthesis coupled electron transport
FRT63_RS05425	COG0772	Belongs to the SEDS family
FRT63_RS05430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FRT63_RS05435	COG2094	Belongs to the DNA glycosylase MPG family
FRT63_RS05445	COG2255	four-way junction helicase activity
FRT63_RS05450	COG0632	four-way junction helicase activity
FRT63_RS05490	COG0494	nUDIX hydrolase
FRT63_RS05495	COG0084	hydrolase, TatD family'
FRT63_RS05505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT63_RS05515	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT63_RS05540	COG1090	epimerase
FRT63_RS05560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FRT63_RS05565	COG1054	Belongs to the UPF0176 family
FRT63_RS05570	COG1178	ABC-type Fe3 transport system permease component
FRT63_RS05580	COG3344	reverse transcriptase
FRT63_RS05600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FRT63_RS05605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FRT63_RS05605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FRT63_RS05610	COG0628	permease
FRT63_RS05620	COG4974	Belongs to the 'phage' integrase family
FRT63_RS05630	COG0268	Binds directly to 16S ribosomal RNA
FRT63_RS05635	COG0372	Belongs to the citrate synthase family
FRT63_RS05650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRT63_RS05660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FRT63_RS05665	COG0259	pyridoxamine-phosphate oxidase activity
FRT63_RS05675	COG0658	competence protein
FRT63_RS05675	COG2333	competence protein COMEC
FRT63_RS05685	COG0564	pseudouridine synthase activity
FRT63_RS05700	COG0126	phosphoglycerate kinase activity
FRT63_RS05710	COG2070	2-Nitropropane dioxygenase
FRT63_RS05725	COG3451	type IV secretory pathway VirB4
FRT63_RS05745	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRT63_RS05760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FRT63_RS05770	COG0105	UTP biosynthetic process
FRT63_RS05780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRT63_RS05800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FRT63_RS05810	COG0142	geranyltranstransferase activity
FRT63_RS05815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRT63_RS05820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRT63_RS05830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRT63_RS05835	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FRT63_RS05850	COG0723	plastoquinol--plastocyanin reductase activity
FRT63_RS05885	COG1268	BioY protein
FRT63_RS05890	COG0778	Nitroreductase
FRT63_RS05900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FRT63_RS05905	COG0045	succinate-CoA ligase (ADP-forming) activity
FRT63_RS05920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRT63_RS05950	COG1475	DNA binding
FRT63_RS05970	COG2009	succinate dehydrogenase
FRT63_RS05975	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FRT63_RS06005	COG4591	ABC-type transport system involved in lipoprotein release permease component
FRT63_RS06020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FRT63_RS06025	COG0312	modulator of DNA gyrase
FRT63_RS06030	COG1278	Cold shock
FRT63_RS06035	COG0513	Belongs to the DEAD box helicase family
FRT63_RS06045	COG1830	Aldolase
FRT63_RS06055	COG0167	dihydroorotate dehydrogenase activity
FRT63_RS06070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRT63_RS06110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FRT63_RS06120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRT63_RS06125	COG0037	tRNA processing
FRT63_RS06130	COG2885	chlorophyll binding
FRT63_RS06145	COG0482	sulfurtransferase activity
FRT63_RS06160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FRT63_RS06170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRT63_RS06175	COG0493	'glutamate synthase
FRT63_RS06175	COG0543	2 iron, 2 sulfur cluster binding
FRT63_RS06190	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FRT63_RS06205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FRT63_RS06225	COG0326	Molecular chaperone. Has ATPase activity
FRT63_RS06235	COG0156	8-amino-7-oxononanoate synthase activity
FRT63_RS06245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FRT63_RS06255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRT63_RS06260	COG2205	protein histidine kinase activity
FRT63_RS06260	COG2202	Pas domain
FRT63_RS06265	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRT63_RS06270	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRT63_RS06295	COG1295	ribonuclease BN
FRT63_RS06300	COG1028	Short-chain dehydrogenase reductase Sdr
FRT63_RS06305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FRT63_RS06325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRT63_RS06330	COG1006	Multisubunit Na H antiporter MnhC subunit
FRT63_RS06340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRT63_RS06340	COG2111	Na H antiporter
FRT63_RS06365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FRT63_RS06375	COG0567	Dehydrogenase, E1 component
FRT63_RS06400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FRT63_RS06410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRT63_RS06415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FRT63_RS06420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FRT63_RS06430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRT63_RS06440	COG0174	glutamine synthetase