locus-tag	class	description
FRT61_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FRT61_RS00025	COG3736	Type IV secretory pathway, component VirB8
FRT61_RS00040	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FRT61_RS00045	COG3505	Type IV secretory pathway VirD4
FRT61_RS00055	COG2890	protein-(glutamine-N5) methyltransferase activity
FRT61_RS00060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRT61_RS00075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRT61_RS00090	COG0250	Participates in transcription elongation, termination and antitermination
FRT61_RS00095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FRT61_RS00100	COG0081	regulation of translation
FRT61_RS00105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FRT61_RS00110	COG0222	ribosome binding
FRT61_RS00115	COG0085	RNA polymerase activity
FRT61_RS00115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FRT61_RS00120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRT61_RS00135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FRT61_RS00165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRT61_RS00170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRT61_RS00175	COG0823	Involved in the tonB-independent uptake of proteins
FRT61_RS00185	COG0484	heat shock protein binding
FRT61_RS00250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FRT61_RS00260	COG0776	regulation of translation
FRT61_RS00275	COG0495	leucyl-tRNA aminoacylation
FRT61_RS00285	COG2801	Transposase and inactivated derivatives
FRT61_RS00300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FRT61_RS00315	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FRT61_RS00325	COG3827	peptidoglycan binding
FRT61_RS00330	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FRT61_RS00370	COG2801	Transposase and inactivated derivatives
FRT61_RS00395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FRT61_RS00400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRT61_RS00405	COG2801	Transposase and inactivated derivatives
FRT61_RS00425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRT61_RS00435	COG0149	triose-phosphate isomerase activity
FRT61_RS00440	COG0758	DNA mediated transformation
FRT61_RS00445	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FRT61_RS00460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FRT61_RS00465	COG1686	Belongs to the peptidase S11 family
FRT61_RS00490	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FRT61_RS00505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRT61_RS00520	COG0187	DNA topoisomerase II activity
FRT61_RS00545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FRT61_RS00560	COG1674	ftsk spoiiie
FRT61_RS00615	COG0307	riboflavin synthase, alpha
FRT61_RS00625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FRT61_RS00630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRT61_RS00640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FRT61_RS00645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FRT61_RS00655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FRT61_RS00670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRT61_RS00680	COG1845	cytochrome c oxidase, subunit III
FRT61_RS00685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FRT61_RS00690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRT61_RS00700	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRT61_RS00715	COG0215	cysteine-tRNA ligase activity
FRT61_RS00720	COG3932	Exopolysaccharide synthesis, ExoD
FRT61_RS00730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRT61_RS00735	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FRT61_RS00745	COG0322	excinuclease ABC activity
FRT61_RS00755	COG0752	glycyl-tRNA synthetase alpha subunit
FRT61_RS00765	COG0113	porphobilinogen synthase activity
FRT61_RS00770	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FRT61_RS00795	COG1573	uracil-dna glycosylase
FRT61_RS00800	COG0242	peptide deformylase activity
FRT61_RS00805	COG0849	cell division
FRT61_RS00810	COG0024	Methionine aminopeptidase
FRT61_RS00815	COG0477	Major facilitator Superfamily
FRT61_RS00820	COG0275	rRNA processing
FRT61_RS00840	COG0193	aminoacyl-tRNA hydrolase activity
FRT61_RS00855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRT61_RS00890	COG2801	Transposase and inactivated derivatives
FRT61_RS00905	COG0237	dephospho-CoA kinase activity
FRT61_RS00910	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FRT61_RS00920	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRT61_RS00935	COG1253	flavin adenine dinucleotide binding
FRT61_RS00945	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FRT61_RS00945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRT61_RS00980	COG0573	inorganic phosphate transmembrane transporter activity
FRT61_RS00985	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FRT61_RS00990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FRT61_RS01000	COG2801	Transposase and inactivated derivatives
FRT61_RS01015	COG0235	Class ii aldolase
FRT61_RS01055	COG4804	nuclease activity
FRT61_RS01060	COG1381	Involved in DNA repair and RecF pathway recombination
FRT61_RS01075	COG2902	Dehydrogenase
FRT61_RS01080	COG0542	response to heat
FRT61_RS01095	COG1217	gtp-binding protein TYPA
FRT61_RS01100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FRT61_RS01105	COG1823	symporter activity
FRT61_RS01120	COG1138	Cytochrome C-type biogenesis protein
FRT61_RS01140	COG3577	Aspartyl protease
FRT61_RS01175	COG0756	dUTP diphosphatase activity
FRT61_RS01180	COG0525	valine-tRNA ligase activity
FRT61_RS01185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FRT61_RS01190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FRT61_RS01195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FRT61_RS01200	COG2814	Major facilitator Superfamily
FRT61_RS01225	COG2801	Transposase and inactivated derivatives
FRT61_RS01230	COG1322	Protein conserved in bacteria
FRT61_RS01240	COG3328	transposase activity
FRT61_RS01290	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FRT61_RS01450	COG2963	transposase activity
FRT61_RS01460	COG2801	Transposase and inactivated derivatives
FRT61_RS01465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FRT61_RS01470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRT61_RS01475	COG0109	protoheme IX farnesyltransferase activity
FRT61_RS01480	COG0328	RNA-DNA hybrid ribonuclease activity
FRT61_RS01490	COG0459	protein refolding
FRT61_RS01495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FRT61_RS01500	COG0354	folic acid binding
FRT61_RS01505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRT61_RS01525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRT61_RS01535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FRT61_RS01540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FRT61_RS01545	COG0740	serine-type endopeptidase activity
FRT61_RS01550	COG0544	peptidyl-prolyl cis-trans isomerase activity
FRT61_RS01580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRT61_RS01615	COG1115	amino acid carrier protein
FRT61_RS01625	COG0424	maF-like protein
FRT61_RS01645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FRT61_RS01660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FRT61_RS01690	COG2801	Transposase and inactivated derivatives
FRT61_RS01695	COG2801	Transposase and inactivated derivatives
FRT61_RS01710	COG0358	DNA primase activity
FRT61_RS01720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRT61_RS01730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRT61_RS01740	COG0305	Participates in initiation and elongation during chromosome replication
FRT61_RS01750	COG1714	RDD family
FRT61_RS01755	COG2003	Belongs to the UPF0758 family
FRT61_RS01765	COG1074	ATP-dependent DNA helicase activity
FRT61_RS01770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FRT61_RS01780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FRT61_RS01805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FRT61_RS01825	COG2801	Transposase and inactivated derivatives
FRT61_RS01835	COG2239	Acts as a magnesium transporter
FRT61_RS01880	COG2814	Major facilitator Superfamily
FRT61_RS01895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FRT61_RS01920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FRT61_RS01925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRT61_RS01930	COG2226	methyltransferase
FRT61_RS01970	COG1132	(ABC) transporter
FRT61_RS01980	COG0018	arginyl-trna synthetase
FRT61_RS02005	COG4133	protoheme IX ABC transporter activity
FRT61_RS02015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FRT61_RS02020	COG0477	Major facilitator Superfamily
FRT61_RS02025	COG0564	pseudouridine synthase activity
FRT61_RS02030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FRT61_RS02035	COG1981	membrane
FRT61_RS02045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRT61_RS02055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FRT61_RS02065	COG0072	phenylalanine-tRNA ligase activity
FRT61_RS02065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRT61_RS02075	COG0356	it plays a direct role in the translocation of protons across the membrane
FRT61_RS02080	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRT61_RS02100	COG1612	heme a metabolic process
FRT61_RS02105	COG4770	biotin carboxylase activity
FRT61_RS02115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRT61_RS02125	COG1053	succinate dehydrogenase
FRT61_RS02135	COG0194	GDP metabolic process
FRT61_RS02155	COG0012	GTP binding
FRT61_RS02165	COG0617	tRNA 3'-terminal CCA addition
FRT61_RS02195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FRT61_RS02200	COG0805	protein transport
FRT61_RS02205	COG1438	arginine binding
FRT61_RS02210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRT61_RS02215	COG0765	amino acid transport
FRT61_RS02220	COG1126	abc transporter atp-binding protein
FRT61_RS02245	COG0284	orotidine-5'-phosphate decarboxylase activity
FRT61_RS02260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRT61_RS02265	COG0525	valine-tRNA ligase activity
FRT61_RS02285	COG0504	CTP synthase activity
FRT61_RS02290	COG0590	tRNA wobble adenosine to inosine editing
FRT61_RS02295	COG0477	Major facilitator Superfamily
FRT61_RS02305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRT61_RS02310	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRT61_RS02310	COG0022	dehydrogenase e1 component
FRT61_RS02320	COG0481	GTPase activity
FRT61_RS02350	COG0739	heme binding
FRT61_RS02355	COG0217	transcriptional regulatory protein
FRT61_RS02360	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRT61_RS02370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FRT61_RS02375	COG0280	phosphate acetyltransferase
FRT61_RS02375	COG0281	malic enzyme
FRT61_RS02395	COG0114	fumarate hydratase activity
FRT61_RS02400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FRT61_RS02405	COG0148	phosphopyruvate hydratase activity
FRT61_RS02410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRT61_RS02440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRT61_RS02445	COG0154	amidase activity
FRT61_RS02465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FRT61_RS02520	COG2963	transposase activity
FRT61_RS02530	COG2801	Transposase and inactivated derivatives
FRT61_RS02550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FRT61_RS02560	COG0575	Belongs to the CDS family
FRT61_RS02565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FRT61_RS02575	COG0233	cytoplasmic translational termination
FRT61_RS02580	COG0528	UMP kinase activity
FRT61_RS02585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FRT61_RS02590	COG0052	Belongs to the universal ribosomal protein uS2 family
FRT61_RS02600	COG1862	Preprotein translocase
FRT61_RS02635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FRT61_RS02645	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRT61_RS02670	COG0653	protein targeting
FRT61_RS02705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FRT61_RS02710	COG0163	prenyltransferase activity
FRT61_RS02715	COG3750	Belongs to the UPF0335 family
FRT61_RS02720	COG4536	flavin adenine dinucleotide binding
FRT61_RS02725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRT61_RS02730	COG0649	NAD binding
FRT61_RS02755	COG3621	Patatin-like phospholipase
FRT61_RS02890	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FRT61_RS02900	COG0666	response to abiotic stimulus
FRT61_RS02970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRT61_RS02975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRT61_RS02980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRT61_RS03000	COG1132	(ABC) transporter
FRT61_RS03025	COG0697	spore germination
FRT61_RS03045	COG2003	Belongs to the UPF0758 family
FRT61_RS03050	COG1396	sequence-specific DNA binding
FRT61_RS03160	COG2963	transposase activity
FRT61_RS03165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRT61_RS03190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRT61_RS03195	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FRT61_RS03200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRT61_RS03205	COG0792	nuclease activity
FRT61_RS03215	COG0202	RNA polymerase activity
FRT61_RS03220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FRT61_RS03225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FRT61_RS03230	COG0563	adenylate kinase activity
FRT61_RS03235	COG0201	protein transport
FRT61_RS03245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FRT61_RS03255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FRT61_RS03265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FRT61_RS03290	COG0255	Belongs to the universal ribosomal protein uL29 family
FRT61_RS03300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FRT61_RS03315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FRT61_RS03325	COG0088	Forms part of the polypeptide exit tunnel
FRT61_RS03330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FRT61_RS03335	COG0051	transcription antitermination factor activity, RNA binding
FRT61_RS03340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRT61_RS03355	COG0505	Belongs to the CarA family
FRT61_RS03370	COG1494	fructose-1,6-bisphosphatase
FRT61_RS03380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRT61_RS03380	COG0574	Belongs to the PEP-utilizing enzyme family
FRT61_RS03395	COG3344	reverse transcriptase
FRT61_RS03405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRT61_RS03420	COG3547	Transposase (IS116 IS110 IS902 family)
FRT61_RS03425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FRT61_RS03435	COG1104	cysteine desulfurase activity
FRT61_RS03440	COG2945	thiolester hydrolase activity
FRT61_RS03455	COG0316	Belongs to the HesB IscA family
FRT61_RS03460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FRT61_RS03465	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRT61_RS03465	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRT61_RS03475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRT61_RS03485	COG2171	N-acyltransferase activity
FRT61_RS03515	COG0768	penicillin binding
FRT61_RS03525	COG0606	chelatase, subunit chli
FRT61_RS03555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FRT61_RS03570	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FRT61_RS03575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FRT61_RS03580	COG0745	RESPONSE REGULATOR receiver
FRT61_RS03595	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FRT61_RS03600	COG0343	queuine tRNA-ribosyltransferase activity
FRT61_RS03610	COG0612	Peptidase, M16
FRT61_RS03615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FRT61_RS03625	COG1271	oxidase subunit
FRT61_RS03630	COG1294	oxidase, subunit
FRT61_RS03635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FRT61_RS03675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRT61_RS03680	COG4974	Belongs to the 'phage' integrase family
FRT61_RS03700	COG0450	alkyl hydroperoxide reductase
FRT61_RS03715	COG0196	riboflavin kinase activity
FRT61_RS03720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FRT61_RS03725	COG0612	Peptidase, M16
FRT61_RS03735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FRT61_RS03760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FRT61_RS03790	COG0629	single-stranded DNA binding
FRT61_RS03795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRT61_RS03800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FRT61_RS03805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRT61_RS03815	COG0360	Binds together with S18 to 16S ribosomal RNA
FRT61_RS03825	COG0359	binds to the 23S rRNA
FRT61_RS03840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FRT61_RS03855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRT61_RS03860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRT61_RS03870	COG0473	3-isopropylmalate dehydrogenase activity
FRT61_RS03885	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FRT61_RS03905	COG0142	geranyltranstransferase activity
FRT61_RS03910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRT61_RS03925	COG3474	cytochrome
FRT61_RS03945	COG0442	prolyl-tRNA aminoacylation
FRT61_RS03950	COG0736	holo-[acyl-carrier-protein] synthase activity
FRT61_RS03980	COG0009	L-threonylcarbamoyladenylate synthase
FRT61_RS03990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FRT61_RS04000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FRT61_RS04050	COG0330	HflC and HflK could
FRT61_RS04080	COG0556	nucleotide-excision repair
FRT61_RS04100	COG4235	cytochrome complex assembly
FRT61_RS04100	COG3088	subunit of a heme lyase
FRT61_RS04120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FRT61_RS04135	COG0742	ribosomal rna small subunit methyltransferase
FRT61_RS04150	COG3704	protein secretion by the type IV secretion system
FRT61_RS04150	COG1340	protein secretion by the type IV secretion system
FRT61_RS04155	COG3704	protein secretion by the type IV secretion system
FRT61_RS04160	COG3704	protein secretion by the type IV secretion system
FRT61_RS04165	COG3451	type IV secretory pathway VirB4
FRT61_RS04175	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FRT61_RS04190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FRT61_RS04205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FRT61_RS04210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FRT61_RS04230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FRT61_RS04235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FRT61_RS04240	COG0254	rRNA binding
FRT61_RS04245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRT61_RS04305	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FRT61_RS04335	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FRT61_RS04340	COG0552	protein localization to endoplasmic reticulum
FRT61_RS04345	COG0822	iron-sulfur transferase activity
FRT61_RS04350	COG0316	Belongs to the HesB IscA family
FRT61_RS04355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FRT61_RS04365	COG0681	Belongs to the peptidase S26 family
FRT61_RS04375	COG1840	ABC-type Fe3 transport system, periplasmic component
FRT61_RS04420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRT61_RS04425	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FRT61_RS04430	COG1185	polyribonucleotide nucleotidyltransferase activity
FRT61_RS04465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRT61_RS04510	COG0626	cystathionine gamma-synthase activity
FRT61_RS04520	COG0443	Heat shock 70 kDa protein
FRT61_RS04525	COG1530	ribonuclease E activity
FRT61_RS04530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FRT61_RS04565	COG1121	(ABC) transporter
FRT61_RS04570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRT61_RS04625	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FRT61_RS04630	COG0670	Belongs to the BI1 family
FRT61_RS04635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRT61_RS04645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FRT61_RS04665	COG0531	amino acid
FRT61_RS04680	COG0527	aspartate kinase activity
FRT61_RS04710	COG0839	Belongs to the complex I subunit 6 family
FRT61_RS04715	COG0713	ATP synthesis coupled electron transport
FRT61_RS04720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRT61_RS04725	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT61_RS04730	COG1007	ATP synthesis coupled electron transport
FRT61_RS04735	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FRT61_RS04735	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FRT61_RS04735	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FRT61_RS04735	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FRT61_RS04740	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FRT61_RS04770	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FRT61_RS04775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FRT61_RS04780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FRT61_RS04790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT61_RS04795	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FRT61_RS04805	COG0492	ferredoxin-NADP+ reductase activity
FRT61_RS04815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRT61_RS04820	COG0416	fatty acid biosynthetic process
FRT61_RS04825	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FRT61_RS04830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRT61_RS04835	COG1127	ABC transporter
FRT61_RS04845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FRT61_RS04860	COG3344	reverse transcriptase
FRT61_RS04870	COG1104	cysteine desulfurase activity
FRT61_RS04875	COG0312	modulator of DNA gyrase
FRT61_RS04905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRT61_RS04905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRT61_RS04910	COG2801	Transposase and inactivated derivatives
FRT61_RS04945	COG0445	tRNA wobble uridine modification
FRT61_RS04965	COG4695	Portal protein
FRT61_RS04980	COG0321	lipoyl(octanoyl) transferase activity
FRT61_RS05000	COG0047	phosphoribosylformylglycinamidine synthase activity
FRT61_RS05020	COG0336	Belongs to the RNA methyltransferase TrmD family
FRT61_RS05025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FRT61_RS05030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FRT61_RS05045	COG1253	flavin adenine dinucleotide binding
FRT61_RS05050	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FRT61_RS05055	COG0436	Aminotransferase
FRT61_RS05080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FRT61_RS05100	COG1230	cation diffusion facilitator family transporter
FRT61_RS05110	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FRT61_RS05115	COG1115	amino acid carrier protein
FRT61_RS05120	COG1115	amino acid carrier protein
FRT61_RS05125	COG1183	phosphatidylcholine synthase activity
FRT61_RS05135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FRT61_RS05140	COG0484	heat shock protein binding
FRT61_RS05145	COG0285	dihydrofolate synthase activity
FRT61_RS05160	COG2867	negative regulation of translational initiation
FRT61_RS05195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FRT61_RS05200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FRT61_RS05210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRT61_RS05225	COG0101	tRNA pseudouridine synthase activity
FRT61_RS05240	COG2857	Cytochrome c1
FRT61_RS05240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRT61_RS05245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRT61_RS05260	COG0484	heat shock protein binding
FRT61_RS05270	COG0124	histidyl-tRNA synthetase
FRT61_RS05275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FRT61_RS05280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FRT61_RS05290	COG0493	'glutamate synthase
FRT61_RS05290	COG0543	2 iron, 2 sulfur cluster binding
FRT61_RS05295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FRT61_RS05310	COG0750	zinc metalloprotease
FRT61_RS05325	COG0776	regulation of translation
FRT61_RS05330	COG0539	negative regulation of cytoplasmic translation
FRT61_RS05335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FRT61_RS05360	COG1160	GTP binding
FRT61_RS05370	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FRT61_RS05375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRT61_RS05380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRT61_RS05400	COG0651	ATP synthesis coupled electron transport
FRT61_RS05405	COG0772	Belongs to the SEDS family
FRT61_RS05410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FRT61_RS05415	COG2094	Belongs to the DNA glycosylase MPG family
FRT61_RS05425	COG2255	four-way junction helicase activity
FRT61_RS05430	COG0632	four-way junction helicase activity
FRT61_RS05470	COG0494	nUDIX hydrolase
FRT61_RS05475	COG0084	hydrolase, TatD family'
FRT61_RS05485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT61_RS05495	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT61_RS05520	COG1090	epimerase
FRT61_RS05540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FRT61_RS05545	COG1054	Belongs to the UPF0176 family
FRT61_RS05550	COG1178	ABC-type Fe3 transport system permease component
FRT61_RS05560	COG3344	reverse transcriptase
FRT61_RS05580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FRT61_RS05585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FRT61_RS05585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FRT61_RS05590	COG0628	permease
FRT61_RS05600	COG4974	Belongs to the 'phage' integrase family
FRT61_RS05610	COG0268	Binds directly to 16S ribosomal RNA
FRT61_RS05615	COG0372	Belongs to the citrate synthase family
FRT61_RS05630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRT61_RS05640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FRT61_RS05645	COG0259	pyridoxamine-phosphate oxidase activity
FRT61_RS05655	COG2333	competence protein COMEC
FRT61_RS05655	COG0658	competence protein
FRT61_RS05665	COG0564	pseudouridine synthase activity
FRT61_RS05680	COG0126	phosphoglycerate kinase activity
FRT61_RS05690	COG2070	2-Nitropropane dioxygenase
FRT61_RS05705	COG3451	type IV secretory pathway VirB4
FRT61_RS05725	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRT61_RS05740	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FRT61_RS05750	COG0105	UTP biosynthetic process
FRT61_RS05760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRT61_RS05780	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FRT61_RS05790	COG0142	geranyltranstransferase activity
FRT61_RS05795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRT61_RS05800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRT61_RS05810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRT61_RS05815	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FRT61_RS05830	COG0723	plastoquinol--plastocyanin reductase activity
FRT61_RS05865	COG1268	BioY protein
FRT61_RS05870	COG0778	Nitroreductase
FRT61_RS05880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FRT61_RS05885	COG0045	succinate-CoA ligase (ADP-forming) activity
FRT61_RS05900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRT61_RS05930	COG1475	DNA binding
FRT61_RS05950	COG2009	succinate dehydrogenase
FRT61_RS05955	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FRT61_RS05985	COG4591	ABC-type transport system involved in lipoprotein release permease component
FRT61_RS06000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FRT61_RS06005	COG0312	modulator of DNA gyrase
FRT61_RS06010	COG1278	Cold shock
FRT61_RS06015	COG0513	Belongs to the DEAD box helicase family
FRT61_RS06025	COG1830	Aldolase
FRT61_RS06035	COG0167	dihydroorotate dehydrogenase activity
FRT61_RS06050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRT61_RS06090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FRT61_RS06100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRT61_RS06105	COG0037	tRNA processing
FRT61_RS06110	COG2885	chlorophyll binding
FRT61_RS06125	COG0482	sulfurtransferase activity
FRT61_RS06140	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FRT61_RS06150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRT61_RS06155	COG0493	'glutamate synthase
FRT61_RS06155	COG0543	2 iron, 2 sulfur cluster binding
FRT61_RS06170	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FRT61_RS06185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FRT61_RS06205	COG0326	Molecular chaperone. Has ATPase activity
FRT61_RS06215	COG0156	8-amino-7-oxononanoate synthase activity
FRT61_RS06225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FRT61_RS06235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRT61_RS06240	COG2205	protein histidine kinase activity
FRT61_RS06240	COG2202	Pas domain
FRT61_RS06245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRT61_RS06250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRT61_RS06270	COG1295	ribonuclease BN
FRT61_RS06275	COG1028	Short-chain dehydrogenase reductase Sdr
FRT61_RS06280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FRT61_RS06300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRT61_RS06305	COG1006	Multisubunit Na H antiporter MnhC subunit
FRT61_RS06315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRT61_RS06315	COG2111	Na H antiporter
FRT61_RS06340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FRT61_RS06350	COG0567	Dehydrogenase, E1 component
FRT61_RS06375	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FRT61_RS06385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRT61_RS06390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FRT61_RS06395	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FRT61_RS06405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRT61_RS06415	COG0174	glutamine synthetase