locus-tag	class	description
WRI_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WRI_RS00030	COG3736	Type IV secretory pathway, component VirB8
WRI_RS00045	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WRI_RS00050	COG3505	Type IV secretory pathway VirD4
WRI_RS00080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WRI_RS00095	COG0250	Participates in transcription elongation, termination and antitermination
WRI_RS00100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WRI_RS00105	COG0081	regulation of translation
WRI_RS00110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WRI_RS00115	COG0222	ribosome binding
WRI_RS00120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WRI_RS00120	COG0085	RNA polymerase activity
WRI_RS00125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WRI_RS00135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WRI_RS00155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WRI_RS00160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WRI_RS00220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WRI_RS00300	COG3827	peptidoglycan binding
WRI_RS00305	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WRI_RS00390	COG0489	protein tyrosine kinase activity
WRI_RS00395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WRI_RS00430	COG0477	Major facilitator Superfamily
WRI_RS00435	COG0024	Methionine aminopeptidase
WRI_RS00440	COG0849	cell division
WRI_RS00450	COG1573	uracil-dna glycosylase
WRI_RS00465	COG1034	ATP synthesis coupled electron transport
WRI_RS00470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WRI_RS00475	COG0113	porphobilinogen synthase activity
WRI_RS00485	COG0752	glycyl-tRNA synthetase alpha subunit
WRI_RS00505	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WRI_RS00510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WRI_RS00520	COG3932	Exopolysaccharide synthesis, ExoD
WRI_RS00565	COG1845	cytochrome c oxidase, subunit III
WRI_RS00575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WRI_RS00580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WRI_RS00590	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WRI_RS00600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WRI_RS00615	COG0307	riboflavin synthase, alpha
WRI_RS00640	COG1674	ftsk spoiiie
WRI_RS00655	COG3344	reverse transcriptase
WRI_RS00715	COG0187	DNA topoisomerase II activity
WRI_RS00725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WRI_RS00740	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WRI_RS00765	COG1686	Belongs to the peptidase S11 family
WRI_RS00770	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WRI_RS00785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WRI_RS00790	COG0758	DNA mediated transformation
WRI_RS00795	COG0149	triose-phosphate isomerase activity
WRI_RS00820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WRI_RS00825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WRI_RS00860	COG0237	dephospho-CoA kinase activity
WRI_RS00865	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WRI_RS00890	COG1253	flavin adenine dinucleotide binding
WRI_RS00900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WRI_RS00900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WRI_RS00930	COG0573	inorganic phosphate transmembrane transporter activity
WRI_RS00940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WRI_RS00965	COG0235	Class ii aldolase
WRI_RS01020	COG2902	Dehydrogenase
WRI_RS01025	COG0542	response to heat
WRI_RS01035	COG1217	gtp-binding protein TYPA
WRI_RS01040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WRI_RS01045	COG1301	dicarboxylic acid transport
WRI_RS01060	COG1138	Cytochrome C-type biogenesis protein
WRI_RS01085	COG3577	Aspartyl protease
WRI_RS01125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WRI_RS01135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WRI_RS01140	COG2814	Major facilitator Superfamily
WRI_RS01160	COG1322	Protein conserved in bacteria
WRI_RS01190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WRI_RS01235	COG0114	fumarate hydratase activity
WRI_RS01255	COG0280	phosphate acetyltransferase
WRI_RS01255	COG0281	malic enzyme
WRI_RS01260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WRI_RS01280	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WRI_RS01290	COG0739	heme binding
WRI_RS01325	COG0805	protein transport
WRI_RS01330	COG1438	arginine binding
WRI_RS01335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WRI_RS01340	COG0765	amino acid transport
WRI_RS01345	COG1126	abc transporter atp-binding protein
WRI_RS01365	COG0284	orotidine-5'-phosphate decarboxylase activity
WRI_RS01385	COG0525	valine-tRNA ligase activity
WRI_RS01405	COG0504	CTP synthase activity
WRI_RS01410	COG0590	tRNA wobble adenosine to inosine editing
WRI_RS01425	COG0477	Major facilitator Superfamily
WRI_RS01435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WRI_RS01440	COG0022	dehydrogenase e1 component
WRI_RS01440	COG0508	dehydrogenase complex catalyzes the overall conversion of
WRI_RS01490	COG0617	tRNA 3'-terminal CCA addition
WRI_RS01500	COG0012	GTP binding
WRI_RS01515	COG0194	GDP metabolic process
WRI_RS01525	COG1053	succinate dehydrogenase
WRI_RS01530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WRI_RS01540	COG4770	biotin carboxylase activity
WRI_RS01565	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WRI_RS01580	COG0072	phenylalanine-tRNA ligase activity
WRI_RS01580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WRI_RS01590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WRI_RS01600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WRI_RS01605	COG1981	membrane
WRI_RS01610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WRI_RS01615	COG0564	pseudouridine synthase activity
WRI_RS01620	COG0477	Major facilitator Superfamily
WRI_RS01635	COG4133	protoheme IX ABC transporter activity
WRI_RS01685	COG0575	Belongs to the CDS family
WRI_RS01690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WRI_RS01700	COG0528	UMP kinase activity
WRI_RS01720	COG1862	Preprotein translocase
WRI_RS01735	COG3344	reverse transcriptase
WRI_RS01765	COG0508	dehydrogenase complex catalyzes the overall conversion of
WRI_RS01800	COG0653	protein targeting
WRI_RS01840	COG3344	reverse transcriptase
WRI_RS01865	COG0163	prenyltransferase activity
WRI_RS01875	COG4536	flavin adenine dinucleotide binding
WRI_RS01880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WRI_RS01885	COG0649	NAD binding
WRI_RS01890	COG2963	transposase activity
WRI_RS01900	COG0018	arginyl-trna synthetase
WRI_RS01920	COG1132	(ABC) transporter
WRI_RS01930	COG3344	reverse transcriptase
WRI_RS01965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WRI_RS01990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WRI_RS02040	COG2814	Major facilitator Superfamily
WRI_RS02065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WRI_RS02070	COG2239	Acts as a magnesium transporter
WRI_RS02075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WRI_RS02115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WRI_RS02130	COG1074	ATP-dependent DNA helicase activity
WRI_RS02140	COG2003	Belongs to the UPF0758 family
WRI_RS02145	COG1714	RDD family
WRI_RS02155	COG0305	Participates in initiation and elongation during chromosome replication
WRI_RS02170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WRI_RS02180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WRI_RS02185	COG0358	DNA primase activity
WRI_RS02225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WRI_RS02260	COG1115	amino acid carrier protein
WRI_RS02290	COG0354	folic acid binding
WRI_RS02295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WRI_RS02310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WRI_RS02320	COG1132	(ABC) transporter
WRI_RS02325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WRI_RS02330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WRI_RS02340	COG0544	peptidyl-prolyl cis-trans isomerase activity
WRI_RS02370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WRI_RS02405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WRI_RS02410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WRI_RS02425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WRI_RS02450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WRI_RS02465	COG0792	nuclease activity
WRI_RS02475	COG0202	RNA polymerase activity
WRI_RS02485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WRI_RS02495	COG0201	protein transport
WRI_RS02505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WRI_RS02515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WRI_RS02525	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WRI_RS02560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WRI_RS02590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WRI_RS02600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WRI_RS02630	COG1494	fructose-1,6-bisphosphatase
WRI_RS02645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WRI_RS02645	COG0574	Belongs to the PEP-utilizing enzyme family
WRI_RS02655	COG3344	reverse transcriptase
WRI_RS02810	COG0666	response to abiotic stimulus
WRI_RS02820	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WRI_RS02855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WRI_RS02860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WRI_RS02865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WRI_RS02885	COG1132	(ABC) transporter
WRI_RS02910	COG0697	spore germination
WRI_RS02930	COG2003	Belongs to the UPF0758 family
WRI_RS02935	COG1396	sequence-specific DNA binding
WRI_RS02945	COG3344	reverse transcriptase
WRI_RS02990	COG0450	alkyl hydroperoxide reductase
WRI_RS03005	COG0196	riboflavin kinase activity
WRI_RS03010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WRI_RS03015	COG0612	Peptidase, M16
WRI_RS03025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WRI_RS03090	COG0629	single-stranded DNA binding
WRI_RS03095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WRI_RS03105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WRI_RS03115	COG0360	Binds together with S18 to 16S ribosomal RNA
WRI_RS03130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WRI_RS03145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WRI_RS03165	COG0473	3-isopropylmalate dehydrogenase activity
WRI_RS03180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WRI_RS03230	COG1104	cysteine desulfurase activity
WRI_RS03235	COG2945	thiolester hydrolase activity
WRI_RS03250	COG0316	Belongs to the HesB IscA family
WRI_RS03255	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WRI_RS03260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WRI_RS03260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WRI_RS03270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WRI_RS03280	COG2171	N-acyltransferase activity
WRI_RS03305	COG0768	penicillin binding
WRI_RS03315	COG2003	Belongs to the UPF0758 family
WRI_RS03415	COG0071	Belongs to the small heat shock protein (HSP20) family
WRI_RS03435	COG0666	response to abiotic stimulus
WRI_RS03455	COG3621	Patatin-like phospholipase
WRI_RS03610	COG4804	nuclease activity
WRI_RS03640	COG4974	Belongs to the 'phage' integrase family
WRI_RS03685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WRI_RS03690	COG1294	oxidase, subunit
WRI_RS03695	COG1271	oxidase subunit
WRI_RS03700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WRI_RS03705	COG0612	Peptidase, M16
WRI_RS03715	COG0343	queuine tRNA-ribosyltransferase activity
WRI_RS03720	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WRI_RS03730	COG0745	RESPONSE REGULATOR receiver
WRI_RS03740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WRI_RS03755	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WRI_RS03780	COG0606	chelatase, subunit chli
WRI_RS03850	COG0142	geranyltranstransferase activity
WRI_RS03870	COG3474	cytochrome
WRI_RS03930	COG0009	L-threonylcarbamoyladenylate synthase
WRI_RS03950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WRI_RS04000	COG0330	HflC and HflK could
WRI_RS04035	COG0556	nucleotide-excision repair
WRI_RS04055	COG4235	cytochrome complex assembly
WRI_RS04055	COG3088	subunit of a heme lyase
WRI_RS04070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WRI_RS04090	COG0742	ribosomal rna small subunit methyltransferase
WRI_RS04105	COG3704	protein secretion by the type IV secretion system
WRI_RS04110	COG3704	protein secretion by the type IV secretion system
WRI_RS04115	COG3704	protein secretion by the type IV secretion system
WRI_RS04120	COG3451	type IV secretory pathway VirB4
WRI_RS04130	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WRI_RS04135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WRI_RS04170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WRI_RS04175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WRI_RS04180	COG0254	rRNA binding
WRI_RS04185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WRI_RS04215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WRI_RS04255	COG1840	ABC-type Fe3 transport system, periplasmic component
WRI_RS04265	COG0681	Belongs to the peptidase S26 family
WRI_RS04270	COG0443	Heat shock 70 kDa protein
WRI_RS04275	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WRI_RS04280	COG0316	Belongs to the HesB IscA family
WRI_RS04285	COG0822	iron-sulfur transferase activity
WRI_RS04290	COG0552	protein localization to endoplasmic reticulum
WRI_RS04295	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WRI_RS04325	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WRI_RS04330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WRI_RS04330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WRI_RS04340	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
WRI_RS04380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WRI_RS04410	COG0626	cystathionine gamma-synthase activity
WRI_RS04425	COG1530	ribonuclease E activity
WRI_RS04445	COG1121	(ABC) transporter
WRI_RS04450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WRI_RS04470	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WRI_RS04475	COG0670	Belongs to the BI1 family
WRI_RS04480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WRI_RS04490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WRI_RS04505	COG0531	amino acid
WRI_RS04515	COG0527	aspartate kinase activity
WRI_RS04580	COG0839	Belongs to the complex I subunit 6 family
WRI_RS04585	COG0713	ATP synthesis coupled electron transport
WRI_RS04590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WRI_RS04595	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WRI_RS04600	COG1007	ATP synthesis coupled electron transport
WRI_RS04605	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WRI_RS04605	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WRI_RS04640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WRI_RS04650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WRI_RS04665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WRI_RS04680	COG0492	ferredoxin-NADP+ reductase activity
WRI_RS04685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WRI_RS04695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WRI_RS04700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WRI_RS04705	COG1127	ABC transporter
WRI_RS04735	COG3344	reverse transcriptase
WRI_RS04745	COG1104	cysteine desulfurase activity
WRI_RS04750	COG0312	modulator of DNA gyrase
WRI_RS04780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WRI_RS04780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WRI_RS04810	COG0006	proline dipeptidase activity
WRI_RS04875	COG4695	Portal protein
WRI_RS04885	COG0321	lipoyl(octanoyl) transferase activity
WRI_RS04900	COG0047	phosphoribosylformylglycinamidine synthase activity
WRI_RS04930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WRI_RS04945	COG1253	flavin adenine dinucleotide binding
WRI_RS04955	COG0436	Aminotransferase
WRI_RS04965	COG0372	Belongs to the citrate synthase family
WRI_RS04980	COG4974	Belongs to the 'phage' integrase family
WRI_RS04990	COG0628	permease
WRI_RS05000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WRI_RS05000	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WRI_RS05005	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WRI_RS05020	COG3344	reverse transcriptase
WRI_RS05175	COG0666	response to abiotic stimulus
WRI_RS05185	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WRI_RS05220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WRI_RS05225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WRI_RS05230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WRI_RS05250	COG1132	(ABC) transporter
WRI_RS05275	COG0697	spore germination
WRI_RS05295	COG2003	Belongs to the UPF0758 family
WRI_RS05300	COG1396	sequence-specific DNA binding
WRI_RS05310	COG3344	reverse transcriptase
WRI_RS05320	COG1178	ABC-type Fe3 transport system permease component
WRI_RS05325	COG1054	Belongs to the UPF0176 family
WRI_RS05330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WRI_RS05380	COG0477	Major facilitator Superfamily
WRI_RS05415	COG1230	cation diffusion facilitator family transporter
WRI_RS05425	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WRI_RS05430	COG1115	amino acid carrier protein
WRI_RS05435	COG1115	amino acid carrier protein
WRI_RS05440	COG1183	phosphatidylcholine synthase activity
WRI_RS05475	COG0484	heat shock protein binding
WRI_RS05480	COG0285	dihydrofolate synthase activity
WRI_RS05490	COG2867	negative regulation of translational initiation
WRI_RS05495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WRI_RS05520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WRI_RS05525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WRI_RS05535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WRI_RS05565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WRI_RS05565	COG2857	Cytochrome c1
WRI_RS05570	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WRI_RS05585	COG0484	heat shock protein binding
WRI_RS05605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WRI_RS05615	COG0543	2 iron, 2 sulfur cluster binding
WRI_RS05615	COG0493	'glutamate synthase
WRI_RS05635	COG0750	zinc metalloprotease
WRI_RS05650	COG0776	regulation of translation
WRI_RS05655	COG0539	negative regulation of cytoplasmic translation
WRI_RS05660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WRI_RS05675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WRI_RS05690	COG0259	pyridoxamine-phosphate oxidase activity
WRI_RS05700	COG2333	competence protein COMEC
WRI_RS05700	COG0658	competence protein
WRI_RS05710	COG0564	pseudouridine synthase activity
WRI_RS05735	COG2070	2-Nitropropane dioxygenase
WRI_RS05750	COG3451	type IV secretory pathway VirB4
WRI_RS05770	COG0508	dehydrogenase complex catalyzes the overall conversion of
WRI_RS05785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WRI_RS05820	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WRI_RS05835	COG0142	geranyltranstransferase activity
WRI_RS05840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WRI_RS05845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WRI_RS05870	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WRI_RS05905	COG0723	plastoquinol--plastocyanin reductase activity
WRI_RS05930	COG1268	BioY protein
WRI_RS05935	COG0778	Nitroreductase
WRI_RS05965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WRI_RS05995	COG1475	DNA binding
WRI_RS06010	COG2009	succinate dehydrogenase
WRI_RS06025	COG4591	ABC-type transport system involved in lipoprotein release permease component
WRI_RS06045	COG0312	modulator of DNA gyrase
WRI_RS06050	COG1278	Cold shock
WRI_RS06055	COG0513	Belongs to the DEAD box helicase family
WRI_RS06070	COG1830	Aldolase
WRI_RS06080	COG0167	dihydroorotate dehydrogenase activity
WRI_RS06095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WRI_RS06120	COG3346	SURF1 family
WRI_RS06135	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WRI_RS06145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WRI_RS06155	COG2885	chlorophyll binding
WRI_RS06180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WRI_RS06190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WRI_RS06195	COG0543	2 iron, 2 sulfur cluster binding
WRI_RS06195	COG0493	'glutamate synthase
WRI_RS06210	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WRI_RS06380	COG1160	GTP binding
WRI_RS06390	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
WRI_RS06420	COG0651	ATP synthesis coupled electron transport
WRI_RS06425	COG0772	Belongs to the SEDS family
WRI_RS06430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WRI_RS06435	COG2094	Belongs to the DNA glycosylase MPG family
WRI_RS06480	COG0084	hydrolase, TatD family'
WRI_RS06490	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WRI_RS06525	COG1090	epimerase
WRI_RS06535	COG0326	Molecular chaperone. Has ATPase activity
WRI_RS06550	COG0156	8-amino-7-oxononanoate synthase activity
WRI_RS06570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WRI_RS06575	COG2202	Pas domain
WRI_RS06575	COG2205	protein histidine kinase activity
WRI_RS06580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WRI_RS06585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WRI_RS06610	COG1295	ribonuclease BN
WRI_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
WRI_RS06625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WRI_RS06645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WRI_RS06650	COG1006	Multisubunit Na H antiporter MnhC subunit
WRI_RS06660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WRI_RS06660	COG2111	Na H antiporter
WRI_RS06685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WRI_RS06695	COG0567	Dehydrogenase, E1 component
WRI_RS06720	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WRI_RS06740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WRI_RS06745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WRI_RS06750	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WRI_RS06760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WRI_RS06770	COG0174	glutamine synthetase
WRI_RS06805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins