locus-tag	class	description
WS_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WS_RS00010	COG0592	DNA-directed DNA polymerase activity
WS_RS00015	COG0187	DNA topoisomerase II activity
WS_RS00020	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WS_RS00025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WS_RS00035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WS_RS00040	COG0589	response to stress
WS_RS00050	COG3258	Cytochrome c
WS_RS00065	COG5002	protein histidine kinase activity
WS_RS00075	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
WS_RS00090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WS_RS00105	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WS_RS00110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WS_RS00120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
WS_RS00135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WS_RS00145	COG0437	4 iron, 4 sulfur cluster binding
WS_RS00150	COG3383	formate dehydrogenase (NAD+) activity
WS_RS00170	COG0454	-acetyltransferase
WS_RS00180	COG1086	Polysaccharide biosynthesis protein
WS_RS00185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WS_RS00195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WS_RS00200	COG0438	transferase activity, transferring glycosyl groups
WS_RS00205	COG0367	asparagine synthase
WS_RS00215	COG0438	transferase activity, transferring glycosyl groups
WS_RS00220	COG0367	asparagine synthase
WS_RS00250	COG1132	(ABC) transporter
WS_RS00255	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WS_RS00270	COG1077	Cell shape determining protein MreB Mrl
WS_RS00275	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WS_RS00285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WS_RS00290	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WS_RS00295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WS_RS00305	COG0107	imidazoleglycerol-phosphate synthase activity
WS_RS00310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WS_RS00320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WS_RS00320	COG0517	IMP dehydrogenase activity
WS_RS00335	COG0456	acetyltransferase
WS_RS00340	COG1418	mRNA catabolic process
WS_RS00350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WS_RS00355	COG0552	protein localization to endoplasmic reticulum
WS_RS00360	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WS_RS00375	COG0642	Histidine kinase
WS_RS00385	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WS_RS00390	COG1666	GTP binding
WS_RS00400	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WS_RS00405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WS_RS00420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WS_RS00430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WS_RS00430	COG0140	phosphoribosyl-ATP diphosphatase activity
WS_RS00445	COG1090	epimerase
WS_RS00450	COG0840	transmembrane signaling receptor activity
WS_RS00460	COG1674	ftsk spoiiie
WS_RS00480	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WS_RS00485	COG0440	acetolactate synthase activity
WS_RS00490	COG0028	Belongs to the TPP enzyme family
WS_RS00500	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WS_RS00505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WS_RS00520	COG1127	ABC transporter
WS_RS00525	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WS_RS00530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WS_RS00535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WS_RS00540	COG2207	Transcriptional regulator
WS_RS00545	COG0243	molybdopterin cofactor binding
WS_RS00550	COG0437	4 iron, 4 sulfur cluster binding
WS_RS00555	COG3301	Polysulphide reductase, NrfD
WS_RS00560	COG0745	RESPONSE REGULATOR receiver
WS_RS00565	COG5002	protein histidine kinase activity
WS_RS00570	COG3005	denitrification pathway
WS_RS00580	COG1053	succinate dehydrogenase
WS_RS00585	COG5001	Diguanylate cyclase
WS_RS00585	COG5002	protein histidine kinase activity
WS_RS00590	COG3383	formate dehydrogenase (NAD+) activity
WS_RS00600	COG0840	transmembrane signaling receptor activity
WS_RS00625	COG2056	Na+-H+ antiporter family
WS_RS00630	COG0129	dihydroxy-acid dehydratase activity
WS_RS00635	COG1832	CoA-binding protein
WS_RS00640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WS_RS00685	COG1691	(AIR) carboxylase
WS_RS00690	COG1606	tRNA processing
WS_RS00695	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
WS_RS00700	COG3875	lactate racemase activity
WS_RS00715	COG0564	pseudouridine synthase activity
WS_RS00725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WS_RS00730	COG2884	Cell division ATP-binding protein ftsE
WS_RS00750	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
WS_RS00780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WS_RS00785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WS_RS00805	COG2171	N-acyltransferase activity
WS_RS00810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WS_RS00815	COG0426	domain, Protein
WS_RS00820	COG3123	guanosine phosphorylase activity
WS_RS00835	COG1748	Saccharopine dehydrogenase
WS_RS00840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WS_RS00850	COG0275	rRNA processing
WS_RS00855	COG0280	phosphate acetyltransferase
WS_RS00855	COG0281	malic enzyme
WS_RS00895	COG1546	Belongs to the CinA family
WS_RS00905	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WS_RS00910	COG3278	Belongs to the heme-copper respiratory oxidase family
WS_RS00945	COG0018	arginyl-trna synthetase
WS_RS00950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WS_RS00955	COG0194	GDP metabolic process
WS_RS00975	COG1136	(ABC) transporter
WS_RS00980	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WS_RS00985	COG0052	Belongs to the universal ribosomal protein uS2 family
WS_RS00990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WS_RS00995	COG0398	Pfam SNARE associated Golgi protein
WS_RS01005	COG0398	Pfam SNARE associated Golgi protein
WS_RS01015	COG2233	PERMEase
WS_RS01020	COG1663	tetraacyldisaccharide 4'-kinase activity
WS_RS01030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WS_RS01035	COG2885	chlorophyll binding
WS_RS01035	COG3047	cAMP biosynthetic process
WS_RS01055	COG0784	Response regulator, receiver
WS_RS01055	COG5002	protein histidine kinase activity
WS_RS01055	COG2205	protein histidine kinase activity
WS_RS01065	COG2201	protein-glutamate methylesterase activity
WS_RS01080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS_RS01080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS_RS01090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WS_RS01095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WS_RS01100	COG0135	phosphoribosylanthranilate isomerase activity
WS_RS01105	COG2176	DNA-directed DNA polymerase activity
WS_RS01110	COG2890	protein-(glutamine-N5) methyltransferase activity
WS_RS01115	COG0501	Belongs to the peptidase M48B family
WS_RS01120	COG0504	CTP synthase activity
WS_RS01125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WS_RS01130	COG0446	pyridine nucleotide-disulphide oxidoreductase
WS_RS01150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WS_RS01155	COG0849	cell division
WS_RS01160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WS_RS01165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WS_RS01175	COG0318	PFAM AMP-dependent synthetase and ligase
WS_RS01180	COG0528	UMP kinase activity
WS_RS01185	COG1758	RNA polymerase activity
WS_RS01190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WS_RS01195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WS_RS01205	COG0860	N-Acetylmuramoyl-L-alanine amidase
WS_RS01205	COG2247	cell wall binding repeat
WS_RS01215	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
WS_RS01225	COG0488	(ABC) transporter
WS_RS01250	COG0438	transferase activity, transferring glycosyl groups
WS_RS01260	COG0859	PFAM glycosyl transferase family 9
WS_RS01265	COG0438	transferase activity, transferring glycosyl groups
WS_RS01270	COG1132	(ABC) transporter
WS_RS01275	COG0784	Response regulator, receiver
WS_RS01275	COG0835	chemotaxis
WS_RS01285	COG1256	bacterial-type flagellum assembly
WS_RS01305	COG1196	nuclear chromosome segregation
WS_RS01305	COG0741	lytic transglycosylase activity
WS_RS01305	COG0739	heme binding
WS_RS01320	COG0277	FAD linked oxidase domain protein
WS_RS01330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WS_RS01335	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
WS_RS01350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WS_RS01365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WS_RS01375	COG0765	amino acid transport
WS_RS01390	COG3290	protein histidine kinase activity
WS_RS01390	COG0840	transmembrane signaling receptor activity
WS_RS01415	COG4774	siderophore transport
WS_RS01430	COG0586	Pfam SNARE associated Golgi protein
WS_RS01435	COG1360	Flagellar Motor Protein
WS_RS01440	COG0288	reversible hydration of carbon dioxide
WS_RS01445	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WS_RS01450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WS_RS01455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WS_RS01460	COG0284	orotidine-5'-phosphate decarboxylase activity
WS_RS01470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WS_RS01485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WS_RS01505	COG0745	RESPONSE REGULATOR receiver
WS_RS01515	COG0459	protein refolding
WS_RS01520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WS_RS01530	COG0180	Tryptophanyl-tRNA synthetase
WS_RS01535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WS_RS01535	COG4106	trans-aconitate 2-methyltransferase activity
WS_RS01540	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WS_RS01545	COG0233	cytoplasmic translational termination
WS_RS01550	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WS_RS01565	COG0356	it plays a direct role in the translocation of protons across the membrane
WS_RS01610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WS_RS01615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WS_RS01620	COG0424	maF-like protein
WS_RS01630	COG0492	ferredoxin-NADP+ reductase activity
WS_RS01635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WS_RS01645	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
WS_RS01655	COG0077	Prephenate dehydratase
WS_RS01655	COG1605	Chorismate mutase
WS_RS01660	COG0019	diaminopimelate decarboxylase activity
WS_RS01670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WS_RS01675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WS_RS01685	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WS_RS01705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WS_RS01710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WS_RS01720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WS_RS01725	COG0670	Belongs to the BI1 family
WS_RS01730	COG0352	thiamine-phosphate diphosphorylase activity
WS_RS01735	COG0287	Prephenate dehydrogenase
WS_RS01740	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WS_RS01745	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
WS_RS01750	COG0612	Peptidase, M16
WS_RS01755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WS_RS01760	COG0305	Participates in initiation and elongation during chromosome replication
WS_RS01790	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WS_RS01800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WS_RS01820	COG2204	response regulator
WS_RS01825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WS_RS01835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WS_RS01850	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WS_RS01855	COG0731	radical SAM domain protein
WS_RS01875	COG4191	Histidine kinase
WS_RS01880	COG0484	heat shock protein binding
WS_RS01885	COG0545	Peptidyl-prolyl cis-trans isomerase
WS_RS01890	COG0437	4 iron, 4 sulfur cluster binding
WS_RS01895	COG3301	Polysulphide reductase, NrfD
WS_RS01900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WS_RS01900	COG1333	cytochrome c biogenesis protein
WS_RS01905	COG1981	membrane
WS_RS01930	COG1136	(ABC) transporter
WS_RS01950	COG2258	MOSC domain
WS_RS01975	COG3787	Belongs to the UPF0306 family
WS_RS01980	COG1301	dicarboxylic acid transport
WS_RS01985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WS_RS02015	COG0347	Belongs to the P(II) protein family
WS_RS02020	COG0004	ammonium transporteR
WS_RS02050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WS_RS02055	COG0564	pseudouridine synthase activity
WS_RS02070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WS_RS02085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WS_RS02090	COG0149	triose-phosphate isomerase activity
WS_RS02110	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WS_RS02110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WS_RS02135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WS_RS02145	COG1181	Belongs to the D-alanine--D-alanine ligase family
WS_RS02150	COG1944	ATP diphosphatase activity
WS_RS02155	COG0632	four-way junction helicase activity
WS_RS02165	COG0728	peptidoglycan biosynthetic process
WS_RS02170	COG0215	cysteine-tRNA ligase activity
WS_RS02175	COG0254	rRNA binding
WS_RS02180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WS_RS02185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WS_RS02200	COG0436	Aminotransferase
WS_RS02205	COG0460	homoserine dehydrogenase
WS_RS02210	COG0792	nuclease activity
WS_RS02215	COG3118	belongs to the thioredoxin family
WS_RS02225	COG0492	ferredoxin-NADP+ reductase activity
WS_RS02230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WS_RS02235	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WS_RS02240	COG1242	4 iron, 4 sulfur cluster binding
WS_RS02290	COG0250	Participates in transcription elongation, termination and antitermination
WS_RS02295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WS_RS02300	COG0081	regulation of translation
WS_RS02305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WS_RS02310	COG0222	ribosome binding
WS_RS02315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WS_RS02315	COG0085	RNA polymerase activity
WS_RS02320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WS_RS02325	COG0049	tRNA binding
WS_RS02330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WS_RS02335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WS_RS02340	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WS_RS02345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WS_RS02350	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WS_RS02355	COG0649	NAD binding
WS_RS02380	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WS_RS02385	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WS_RS02390	COG0839	Belongs to the complex I subunit 6 family
WS_RS02395	COG0713	ATP synthesis coupled electron transport
WS_RS02400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WS_RS02410	COG1007	ATP synthesis coupled electron transport
WS_RS02435	COG0443	Heat shock 70 kDa protein
WS_RS02440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WS_RS02445	COG1420	regulation of RNA biosynthetic process
WS_RS02460	COG0776	regulation of translation
WS_RS02470	COG0251	oxidation-reduction process
WS_RS02475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WS_RS02480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WS_RS02485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WS_RS02490	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
WS_RS02495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WS_RS02500	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WS_RS02500	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WS_RS02505	COG1192	Involved in chromosome partitioning
WS_RS02510	COG1475	DNA binding
WS_RS02520	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WS_RS02525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WS_RS02530	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WS_RS02535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WS_RS02540	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WS_RS02545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WS_RS02550	COG0811	peptide transport
WS_RS02555	COG0848	biopolymer transport protein
WS_RS02565	COG0823	Involved in the tonB-independent uptake of proteins
WS_RS02580	COG1047	Peptidyl-prolyl cis-trans
WS_RS02585	COG2204	response regulator
WS_RS02595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WS_RS02665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WS_RS02670	COG1459	type II secretion system
WS_RS02680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WS_RS02685	COG0228	four-way junction DNA binding
WS_RS02695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WS_RS02700	COG0336	Belongs to the RNA methyltransferase TrmD family
WS_RS02705	COG0335	large ribosomal subunit rRNA binding
WS_RS02710	COG1045	serine acetyltransferase
WS_RS02715	COG1166	arginine decarboxylase activity
WS_RS02720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WS_RS02730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WS_RS02735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WS_RS02740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WS_RS02745	COG0347	Belongs to the P(II) protein family
WS_RS02770	COG5016	pyruvate
WS_RS02770	COG0511	ligase activity, forming carbon-carbon bonds
WS_RS02775	COG1570	exodeoxyribonuclease VII activity
WS_RS02780	COG4166	transmembrane transport
WS_RS02785	COG4174	ABC transporter (Permease)
WS_RS02790	COG4239	(ABC) transporter, permease
WS_RS02795	COG4172	Belongs to the ABC transporter superfamily
WS_RS02805	COG0412	Dienelactone hydrolase
WS_RS02810	COG0501	Belongs to the peptidase M48B family
WS_RS02815	COG0754	glutathionylspermidine amidase activity
WS_RS02825	COG0437	4 iron, 4 sulfur cluster binding
WS_RS02835	COG0540	Belongs to the ATCase OTCase family
WS_RS02845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WS_RS02860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
WS_RS02865	COG0196	riboflavin kinase activity
WS_RS02870	COG4106	trans-aconitate 2-methyltransferase activity
WS_RS02875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WS_RS02890	COG4773	Receptor
WS_RS02910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WS_RS02915	COG2176	DNA-directed DNA polymerase activity
WS_RS02925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WS_RS02930	COG3162	membrane
WS_RS02935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WS_RS02945	COG0204	Acyl-transferase
WS_RS02955	COG0047	phosphoribosylformylglycinamidine synthase activity
WS_RS02960	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WS_RS02965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WS_RS02970	COG0793	Belongs to the peptidase S41A family
WS_RS02975	COG0542	response to heat
WS_RS02985	COG0163	prenyltransferase activity
WS_RS02990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WS_RS02995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WS_RS03000	COG1040	competence protein
WS_RS03015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WS_RS03020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WS_RS03025	COG0745	RESPONSE REGULATOR receiver
WS_RS03030	COG2264	protein methyltransferase activity
WS_RS03035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WS_RS03040	COG0688	phosphatidylethanolamine metabolic process
WS_RS03045	COG1183	phosphatidylcholine synthase activity
WS_RS03050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WS_RS03065	COG0825	malonyl-CoA metabolic process
WS_RS03070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WS_RS03075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WS_RS03085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WS_RS03095	COG0348	domain, Protein
WS_RS03115	COG1136	(ABC) transporter
WS_RS03125	COG5002	protein histidine kinase activity
WS_RS03130	COG0745	RESPONSE REGULATOR receiver
WS_RS03135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WS_RS03140	COG2194	sulfuric ester hydrolase activity
WS_RS03160	COG0310	cobalt ion transport
WS_RS03185	COG0659	secondary active sulfate transmembrane transporter activity
WS_RS03205	COG1611	Belongs to the LOG family
WS_RS03210	COG0745	RESPONSE REGULATOR receiver
WS_RS03225	COG0252	asparaginase activity
WS_RS03230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WS_RS03235	COG1027	Aspartate ammonia-lyase
WS_RS03255	COG0500	methyltransferase
WS_RS03265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WS_RS03275	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
WS_RS03285	COG0101	tRNA pseudouridine synthase activity
WS_RS03295	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WS_RS03305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WS_RS03305	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WS_RS03310	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WS_RS03350	COG1959	2 iron, 2 sulfur cluster binding
WS_RS03375	COG3920	Histidine kinase
WS_RS03380	COG0840	transmembrane signaling receptor activity
WS_RS03385	COG0484	heat shock protein binding
WS_RS03395	COG2863	cytochrome
WS_RS03400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WS_RS03430	COG0437	4 iron, 4 sulfur cluster binding
WS_RS03435	COG0243	molybdopterin cofactor binding
WS_RS03450	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
WS_RS03480	COG0133	tryptophan synthase activity
WS_RS03485	COG0778	Nitroreductase
WS_RS03490	COG1686	Belongs to the peptidase S11 family
WS_RS03495	COG1301	dicarboxylic acid transport
WS_RS03535	COG3383	formate dehydrogenase (NAD+) activity
WS_RS03540	COG0437	4 iron, 4 sulfur cluster binding
WS_RS03550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WS_RS03555	COG1924	4 iron, 4 sulfur cluster binding
WS_RS03560	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
WS_RS03565	COG2801	Transposase and inactivated derivatives
WS_RS03580	COG1194	a g-specific adenine glycosylase
WS_RS03585	COG0733	neurotransmitter:sodium symporter activity
WS_RS03615	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
WS_RS03620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WS_RS03655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WS_RS03660	COG0840	transmembrane signaling receptor activity
WS_RS03675	COG0243	molybdopterin cofactor binding
WS_RS03685	COG0640	Transcriptional regulator
WS_RS03690	COG1309	transcriptional regulator
WS_RS03710	COG2200	EAL domain
WS_RS03720	COG1794	racemase activity, acting on amino acids and derivatives
WS_RS03730	COG0579	oxidoreductase
WS_RS03740	COG0716	FMN binding
WS_RS03750	COG0519	Catalyzes the synthesis of GMP from XMP
WS_RS03760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WS_RS03770	COG2171	N-acyltransferase activity
WS_RS03775	COG0351	phosphomethylpyrimidine kinase
WS_RS03780	COG0352	thiamine-phosphate diphosphorylase activity
WS_RS03785	COG0724	RNA recognition motif
WS_RS03790	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
WS_RS03795	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WS_RS03800	COG0298	carbon dioxide binding
WS_RS03815	COG0309	Hydrogenase expression formation protein (HypE)
WS_RS03820	COG0375	protein maturation
WS_RS03835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WS_RS03840	COG0756	dUTP diphosphatase activity
WS_RS03855	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WS_RS03860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WS_RS03870	COG5002	protein histidine kinase activity
WS_RS03870	COG5001	Diguanylate cyclase
WS_RS03880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WS_RS03885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WS_RS03890	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WS_RS03900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WS_RS03905	COG0575	Belongs to the CDS family
WS_RS03915	COG0445	tRNA wobble uridine modification
WS_RS03920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WS_RS03925	COG0268	Binds directly to 16S ribosomal RNA
WS_RS03930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WS_RS03935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WS_RS03945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WS_RS03950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WS_RS03955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WS_RS03960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WS_RS03965	COG0574	Belongs to the PEP-utilizing enzyme family
WS_RS03965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WS_RS03970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WS_RS03985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WS_RS03990	COG1053	succinate dehydrogenase
WS_RS04000	COG0589	response to stress
WS_RS04005	COG0303	'Molybdopterin
WS_RS04020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WS_RS04030	COG1921	L-seryl-tRNASec selenium transferase activity
WS_RS04050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WS_RS04055	COG0330	HflC and HflK could
WS_RS04070	COG5001	Diguanylate cyclase
WS_RS04070	COG3300	MHYT domain
WS_RS04085	COG3437	response regulator, receiver
WS_RS04090	COG2204	response regulator
WS_RS04095	COG0456	acetyltransferase
WS_RS04100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WS_RS04105	COG1917	Cupin 2, conserved barrel domain protein
WS_RS04115	COG0840	transmembrane signaling receptor activity
WS_RS04125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WS_RS04140	COG0840	transmembrane signaling receptor activity
WS_RS04160	COG0357	Ribosomal RNA small subunit methyltransferase G
WS_RS04165	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WS_RS04170	COG0805	protein transport
WS_RS04175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WS_RS04185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WS_RS04200	COG0210	DNA helicase
WS_RS04210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WS_RS04215	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
WS_RS04220	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WS_RS04225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WS_RS04230	COG0811	peptide transport
WS_RS04235	COG0848	biopolymer transport protein
WS_RS04285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WS_RS04295	COG1185	polyribonucleotide nucleotidyltransferase activity
WS_RS04300	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WS_RS04315	COG0745	RESPONSE REGULATOR receiver
WS_RS04320	COG5002	protein histidine kinase activity
WS_RS04325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WS_RS04330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WS_RS04350	COG1116	anion transmembrane transporter activity
WS_RS04355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WS_RS04370	COG4771	TonB-dependent receptor
WS_RS04395	COG4263	nitrous-oxide reductase activity
WS_RS04410	COG0437	4 iron, 4 sulfur cluster binding
WS_RS04425	COG0348	domain, Protein
WS_RS04430	COG1131	(ABC) transporter
WS_RS04455	COG3290	protein histidine kinase activity
WS_RS04455	COG0840	transmembrane signaling receptor activity
WS_RS04460	COG0697	spore germination
WS_RS04465	COG2095	MarC family integral membrane protein
WS_RS04470	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
WS_RS04480	COG0745	RESPONSE REGULATOR receiver
WS_RS04535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WS_RS04540	COG0581	inorganic phosphate transmembrane transporter activity
WS_RS04545	COG0573	inorganic phosphate transmembrane transporter activity
WS_RS04550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WS_RS04555	COG3290	protein histidine kinase activity
WS_RS04555	COG0840	transmembrane signaling receptor activity
WS_RS04560	COG0745	RESPONSE REGULATOR receiver
WS_RS04570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WS_RS04570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WS_RS04575	COG2022	thiamine diphosphate biosynthetic process
WS_RS04585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WS_RS04620	COG2831	hemolysin activation secretion protein
WS_RS04635	COG1979	alcohol dehydrogenase
WS_RS04645	COG2199	diguanylate cyclase activity
WS_RS04645	COG3287	FIST C domain
WS_RS04645	COG2200	EAL domain
WS_RS04660	COG1333	cytochrome c biogenesis protein
WS_RS04660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WS_RS04665	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
WS_RS04670	COG3005	denitrification pathway
WS_RS04675	COG1077	Cell shape determining protein MreB Mrl
WS_RS04685	COG1971	Probably functions as a manganese efflux pump
WS_RS04710	COG0444	Belongs to the ABC transporter superfamily
WS_RS04720	COG0601	transmembrane transport
WS_RS04725	COG0747	negative chemotaxis
WS_RS04735	COG0747	negative chemotaxis
WS_RS04740	COG0601	transmembrane transport
WS_RS04755	COG1124	(ABC) transporter
WS_RS04760	COG0534	Mate efflux family protein
WS_RS04795	COG0668	transmembrane transport
WS_RS04800	COG0709	Synthesizes selenophosphate from selenide and ATP
WS_RS04830	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WS_RS04840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WS_RS04850	COG2895	sulfate adenylyltransferase (ATP) activity
WS_RS04855	COG0175	sulfate reduction
WS_RS04860	COG0175	sulfate reduction
WS_RS04875	COG0500	methyltransferase
WS_RS04880	COG2814	Major facilitator Superfamily
WS_RS04890	COG0217	transcriptional regulatory protein
WS_RS04910	COG0776	regulation of translation
WS_RS04915	COG0840	transmembrane signaling receptor activity
WS_RS04925	COG2199	diguanylate cyclase activity
WS_RS04925	COG2200	EAL domain
WS_RS04925	COG3287	FIST C domain
WS_RS04940	COG0166	Belongs to the GPI family
WS_RS04945	COG0205	6-phosphofructokinase activity
WS_RS04955	COG0126	phosphoglycerate kinase activity
WS_RS04960	COG0598	Magnesium transport protein CorA
WS_RS04965	COG0745	RESPONSE REGULATOR receiver
WS_RS05020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WS_RS05030	COG0803	Belongs to the bacterial solute-binding protein 9 family
WS_RS05045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WS_RS05055	COG2404	hydrolase activity, acting on ester bonds
WS_RS05060	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WS_RS05065	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WS_RS05080	COG1776	CheC inhibitor of MCP methylation
WS_RS05080	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WS_RS05095	COG2081	HI0933 family
WS_RS05110	COG0039	L-malate dehydrogenase activity
WS_RS05115	COG0045	succinate-CoA ligase (ADP-forming) activity
WS_RS05130	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WS_RS05130	COG0674	pyruvate-flavodoxin oxidoreductase activity
WS_RS05135	COG1013	pyruvate-flavodoxin oxidoreductase activity
WS_RS05145	COG0717	Belongs to the dCTP deaminase family
WS_RS05150	COG0511	ligase activity, forming carbon-carbon bonds
WS_RS05155	COG0439	Biotin carboxylase
WS_RS05165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WS_RS05170	COG0745	RESPONSE REGULATOR receiver
WS_RS05250	COG4962	Type ii secretion system protein e
WS_RS05260	COG2948	multi-organism process
WS_RS05315	COG1192	Involved in chromosome partitioning
WS_RS05350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WS_RS05350	COG1116	anion transmembrane transporter activity
WS_RS05360	COG3665	Urea carboxylase-associated protein
WS_RS05365	COG0439	Biotin carboxylase
WS_RS05380	COG0640	Transcriptional regulator
WS_RS05385	COG2217	Heavy metal translocating P-type atpase
WS_RS05390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WS_RS05395	COG1120	ATPase activity
WS_RS05405	COG4772	TonB-dependent receptor
WS_RS05410	COG0500	methyltransferase
WS_RS05420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WS_RS05455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WS_RS05490	COG3383	formate dehydrogenase (NAD+) activity
WS_RS05495	COG0437	4 iron, 4 sulfur cluster binding
WS_RS05505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WS_RS05545	COG4172	Belongs to the ABC transporter superfamily
WS_RS05555	COG0601	transmembrane transport
WS_RS05585	COG2249	NAD(P)H dehydrogenase (quinone) activity
WS_RS05590	COG1733	regulation of RNA biosynthetic process
WS_RS05595	COG1733	regulation of RNA biosynthetic process
WS_RS05615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WS_RS05615	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
WS_RS05620	COG3043	anaerobic respiration
WS_RS05625	COG0348	domain, Protein
WS_RS05630	COG0437	4 iron, 4 sulfur cluster binding
WS_RS05635	COG0243	molybdopterin cofactor binding
WS_RS05640	COG0730	response to heat
WS_RS05660	COG1151	hydroxylamine reductase activity
WS_RS05680	COG1049	propionate catabolic process, 2-methylcitrate cycle
WS_RS05690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WS_RS05710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WS_RS05720	COG0303	'Molybdopterin
WS_RS05730	COG0314	molybdopterin synthase activity
WS_RS05740	COG0521	Mo-molybdopterin cofactor biosynthetic process
WS_RS05745	COG0315	cyclic pyranopterin monophosphate synthase activity
WS_RS05750	COG0493	'glutamate synthase
WS_RS05755	COG0070	glutamate synthase
WS_RS05755	COG0069	glutamate synthase activity
WS_RS05755	COG0067	glutamate synthase
WS_RS05775	COG0745	RESPONSE REGULATOR receiver
WS_RS05785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WS_RS05800	COG2201	protein-glutamate methylesterase activity
WS_RS05805	COG1739	Uncharacterized protein family UPF0029
WS_RS05810	COG1981	membrane
WS_RS05815	COG3290	protein histidine kinase activity
WS_RS05815	COG0840	transmembrane signaling receptor activity
WS_RS05820	COG0165	Argininosuccinate lyase
WS_RS05835	COG0582	viral genome integration into host DNA
WS_RS05840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WS_RS05840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WS_RS05865	COG0302	gtp cyclohydrolase
WS_RS05875	COG0585	pseudouridine synthase activity
WS_RS05885	COG0840	transmembrane signaling receptor activity
WS_RS05900	COG4771	TonB-dependent receptor
WS_RS05905	COG1410	methionine synthase
WS_RS05905	COG0646	methionine synthase
WS_RS05925	COG1692	metallophosphoesterase
WS_RS05930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WS_RS05940	COG0739	heme binding
WS_RS05960	COG0495	leucyl-tRNA aminoacylation
WS_RS05970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WS_RS05975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WS_RS05980	COG1862	Preprotein translocase
WS_RS05985	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WS_RS05990	COG1074	ATP-dependent DNA helicase activity
WS_RS05995	COG0484	heat shock protein binding
WS_RS06000	COG0789	Transcriptional regulator
WS_RS06005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WS_RS06005	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
WS_RS06010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WS_RS06015	COG0653	protein targeting
WS_RS06025	COG2921	Belongs to the UPF0250 family
WS_RS06030	COG0824	Thioesterase
WS_RS06055	COG1132	(ABC) transporter
WS_RS06070	COG1971	Probably functions as a manganese efflux pump
WS_RS06090	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WS_RS06095	COG0157	Belongs to the NadC ModD family
WS_RS06100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WS_RS06105	COG0688	phosphatidylethanolamine metabolic process
WS_RS06110	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WS_RS06125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WS_RS06130	COG0191	fructose-bisphosphate aldolase activity
WS_RS06135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WS_RS06150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WS_RS06160	COG0706	membrane insertase activity
WS_RS06165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WS_RS06175	COG0439	Biotin carboxylase
WS_RS06180	COG1968	undecaprenyl-diphosphatase activity
WS_RS06190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WS_RS06200	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WS_RS06205	COG0359	binds to the 23S rRNA
WS_RS06225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WS_RS06230	COG1115	amino acid carrier protein
WS_RS06235	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WS_RS06250	COG0537	adenosine 5'-monophosphoramidase activity
WS_RS06255	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WS_RS06260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS_RS06260	COG0072	phenylalanine-tRNA ligase activity
WS_RS06265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WS_RS06270	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WS_RS06275	COG1185	polyribonucleotide nucleotidyltransferase activity
WS_RS06275	COG0539	negative regulation of cytoplasmic translation
WS_RS06285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WS_RS06295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WS_RS06300	COG1121	(ABC) transporter
WS_RS06320	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
WS_RS06325	COG0471	metal ion transport
WS_RS06330	COG4783	chaperone-mediated protein folding
WS_RS06335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WS_RS06340	COG1408	metallophosphoesterase
WS_RS06365	COG1280	lysine exporter protein (LysE YggA)
WS_RS06390	COG5278	phosphoserine phosphatase activity
WS_RS06390	COG0840	transmembrane signaling receptor activity
WS_RS06400	COG4753	response regulator
WS_RS06400	COG2207	Transcriptional regulator
WS_RS06410	COG0475	glutathione-regulated potassium exporter activity
WS_RS06410	COG0569	domain protein
WS_RS06420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WS_RS06425	COG0681	Belongs to the peptidase S26 family
WS_RS06430	COG1994	Peptidase M50
WS_RS06435	COG0698	ribose 5-phosphate isomerase
WS_RS06445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WS_RS06450	COG0133	tryptophan synthase activity
WS_RS06455	COG0586	Pfam SNARE associated Golgi protein
WS_RS06460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WS_RS06465	COG0012	GTP binding
WS_RS06535	COG2998	abc-type tungstate transport system, permease component
WS_RS06540	COG4662	Binding-protein-dependent transport system inner membrane component
WS_RS06555	COG1592	Rubrerythrin
WS_RS06565	COG0745	RESPONSE REGULATOR receiver
WS_RS06575	COG0569	domain protein
WS_RS06580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WS_RS06595	COG0633	Ferredoxin
WS_RS06620	COG1433	Dinitrogenase iron-molybdenum cofactor
WS_RS06625	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
WS_RS06630	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
WS_RS06635	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
WS_RS06650	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
WS_RS06660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WS_RS06675	COG1053	succinate dehydrogenase
WS_RS06690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WS_RS06705	COG0840	transmembrane signaling receptor activity
WS_RS06730	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WS_RS06730	COG1918	ferrous iron import across plasma membrane
WS_RS06735	COG1918	ferrous iron import across plasma membrane
WS_RS06745	COG1629	transport
WS_RS06750	COG1538	Outer membrane efflux protein
WS_RS06755	COG1136	(ABC) transporter
WS_RS06755	COG0577	efflux transmembrane transporter activity
WS_RS06760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WS_RS06765	COG4773	Receptor
WS_RS06785	COG4771	TonB-dependent receptor
WS_RS06795	COG0848	biopolymer transport protein
WS_RS06800	COG0811	peptide transport
WS_RS06805	COG0243	molybdopterin cofactor binding
WS_RS06810	COG0437	4 iron, 4 sulfur cluster binding
WS_RS06825	COG4753	response regulator
WS_RS06825	COG2207	Transcriptional regulator
WS_RS06830	COG0747	negative chemotaxis
WS_RS06885	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
WS_RS06915	COG0124	histidyl-tRNA synthetase
WS_RS06920	COG0859	PFAM glycosyl transferase family 9
WS_RS06930	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
WS_RS06935	COG0372	Belongs to the citrate synthase family
WS_RS06940	COG0538	isocitrate dehydrogenase activity
WS_RS06970	COG1942	4-Oxalocrotonate Tautomerase
WS_RS06975	COG3150	esterase
WS_RS06980	COG0745	RESPONSE REGULATOR receiver
WS_RS06985	COG0642	Histidine kinase
WS_RS07025	COG0788	formyltetrahydrofolate deformylase activity
WS_RS07030	COG0616	signal peptide processing
WS_RS07035	COG0402	S-adenosylhomocysteine deaminase activity
WS_RS07040	COG0668	transmembrane transport
WS_RS07045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WS_RS07050	COG0785	Cytochrome C biogenesis protein
WS_RS07060	COG0436	Aminotransferase
WS_RS07075	COG1193	negative regulation of DNA recombination
WS_RS07080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WS_RS07085	COG1987	bacterial-type flagellum assembly
WS_RS07095	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
WS_RS07100	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WS_RS07105	COG0148	phosphopyruvate hydratase activity
WS_RS07120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WS_RS07130	COG1295	ribonuclease BN
WS_RS07135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WS_RS07140	COG0551	DNA topoisomerase type I activity
WS_RS07140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WS_RS07145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WS_RS07160	COG0778	Nitroreductase
WS_RS07165	COG2195	Cleaves the N-terminal amino acid of tripeptides
WS_RS07180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WS_RS07185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WS_RS07195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WS_RS07205	COG0343	queuine tRNA-ribosyltransferase activity
WS_RS07225	COG0745	RESPONSE REGULATOR receiver
WS_RS07245	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
WS_RS07255	COG1802	Transcriptional regulator
WS_RS07265	COG2824	Alkylphosphonate utilization operon protein PhnA
WS_RS07270	COG0501	Belongs to the peptidase M48B family
WS_RS07275	COG4269	membrane
WS_RS07285	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WS_RS07290	COG1607	acyl-coa hydrolase
WS_RS07300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WS_RS07305	COG0415	Belongs to the DNA photolyase family
WS_RS07315	COG0003	Pfam Anion-transporting ATPase
WS_RS07325	COG1966	Carbon starvation protein
WS_RS07335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
WS_RS07350	COG0647	UMP catabolic process
WS_RS07355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WS_RS07360	COG5001	Diguanylate cyclase
WS_RS07360	COG3300	MHYT domain
WS_RS07375	COG1136	(ABC) transporter
WS_RS07375	COG0577	efflux transmembrane transporter activity
WS_RS07400	COG0672	)-iron permease
WS_RS07450	COG4773	Receptor
WS_RS07455	COG0181	hydroxymethylbilane synthase activity
WS_RS07465	COG0442	prolyl-tRNA aminoacylation
WS_RS07470	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WS_RS07475	COG0142	geranyltranstransferase activity
WS_RS07480	COG5337	Spore coat protein CotH
WS_RS07490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WS_RS07495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WS_RS07500	COG1253	flavin adenine dinucleotide binding
WS_RS07505	COG0783	Belongs to the Dps family
WS_RS07510	COG0642	Histidine kinase
WS_RS07515	COG3951	Flagellar rod assembly protein muramidase FlgJ
WS_RS07520	COG1706	bacterial-type flagellum-dependent cell motility
WS_RS07535	COG3340	Belongs to the peptidase S51 family
WS_RS07540	COG2957	Belongs to the agmatine deiminase family
WS_RS07550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WS_RS07555	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
WS_RS07565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WS_RS07565	COG0519	Catalyzes the synthesis of GMP from XMP
WS_RS07570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WS_RS07580	COG0322	excinuclease ABC activity
WS_RS07590	COG4771	TonB-dependent receptor
WS_RS07615	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
WS_RS07640	COG0497	DNA recombination
WS_RS07645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WS_RS07665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WS_RS07675	COG3437	response regulator, receiver
WS_RS07675	COG0784	Response regulator, receiver
WS_RS07700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WS_RS07705	COG0482	sulfurtransferase activity
WS_RS07710	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WS_RS07710	COG1776	CheC inhibitor of MCP methylation
WS_RS07715	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WS_RS07720	COG1191	sigma factor activity
WS_RS07730	COG0455	bacterial-type flagellum organization
WS_RS07735	COG1419	protein localization to endoplasmic reticulum
WS_RS07740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WS_RS07745	COG0006	proline dipeptidase activity
WS_RS07750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WS_RS07755	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WS_RS07760	COG2081	HI0933 family
WS_RS07765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WS_RS07780	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
WS_RS07785	COG0525	valine-tRNA ligase activity
WS_RS07790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WS_RS07800	COG0481	GTPase activity
WS_RS07805	COG0602	queuosine metabolic process
WS_RS07810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WS_RS07815	COG0720	synthase
WS_RS07820	COG1222	aaa ATPase
WS_RS07835	COG0768	penicillin binding
WS_RS07855	COG0772	Belongs to the SEDS family
WS_RS07870	COG0840	transmembrane signaling receptor activity
WS_RS07870	COG3290	protein histidine kinase activity
WS_RS07875	COG0840	transmembrane signaling receptor activity
WS_RS07880	COG0534	Mate efflux family protein
WS_RS07890	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WS_RS07895	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WS_RS07910	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WS_RS07915	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
WS_RS07920	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
WS_RS07925	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
WS_RS07930	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
WS_RS07935	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
WS_RS07940	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
WS_RS07945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WS_RS07960	COG0203	ribosomal protein L17
WS_RS07965	COG0202	RNA polymerase activity
WS_RS07970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WS_RS07975	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WS_RS07980	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WS_RS07985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WS_RS07990	COG0024	Methionine aminopeptidase
WS_RS07995	COG0201	protein transport
WS_RS08000	COG0200	Binds to the 23S rRNA
WS_RS08005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WS_RS08010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WS_RS08015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WS_RS08020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WS_RS08025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WS_RS08030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WS_RS08035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WS_RS08040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WS_RS08045	COG0255	Belongs to the universal ribosomal protein uL29 family
WS_RS08050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WS_RS08055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WS_RS08060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WS_RS08065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WS_RS08070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WS_RS08075	COG0089	rRNA binding
WS_RS08080	COG0088	Forms part of the polypeptide exit tunnel
WS_RS08085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WS_RS08090	COG0051	transcription antitermination factor activity, RNA binding
WS_RS08100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WS_RS08115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WS_RS08120	COG0438	transferase activity, transferring glycosyl groups
WS_RS08135	COG3437	response regulator, receiver
WS_RS08140	COG2198	Histidine kinase
WS_RS08140	COG5002	protein histidine kinase activity
WS_RS08140	COG0784	Response regulator, receiver
WS_RS08145	COG0494	nUDIX hydrolase
WS_RS08150	COG0527	aspartate kinase activity
WS_RS08165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WS_RS08180	COG0326	Molecular chaperone. Has ATPase activity
WS_RS08185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WS_RS08195	COG0428	transporter
WS_RS08200	COG0390	transport system, permease component
WS_RS08215	COG0450	alkyl hydroperoxide reductase
WS_RS08225	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WS_RS08240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WS_RS08250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WS_RS08255	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WS_RS08275	COG1749	Flagellar hook protein flgE
WS_RS08280	COG1749	Flagellar hook protein flgE
WS_RS08295	COG1217	gtp-binding protein TYPA
WS_RS08300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WS_RS08305	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WS_RS08320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WS_RS08325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WS_RS08330	COG0037	tRNA processing
WS_RS08360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WS_RS08370	COG0195	Participates in both transcription termination and antitermination
WS_RS08375	COG4773	Receptor
WS_RS08380	COG4773	Receptor
WS_RS08385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WS_RS08390	COG0563	adenylate kinase activity
WS_RS08400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WS_RS08405	COG0651	ATP synthesis coupled electron transport
WS_RS08415	COG0835	chemotaxis
WS_RS08415	COG0784	Response regulator, receiver
WS_RS08420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WS_RS08425	COG0037	tRNA processing
WS_RS08430	COG2814	Major facilitator Superfamily
WS_RS08435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WS_RS08450	COG0745	RESPONSE REGULATOR receiver
WS_RS08460	COG4786	Flagellar basal body rod
WS_RS08465	COG4786	Flagellar basal body rod
WS_RS08490	COG0157	Belongs to the NadC ModD family
WS_RS08495	COG4149	molybdate abc transporter
WS_RS08515	COG0066	3-isopropylmalate dehydratase activity
WS_RS08520	COG0473	3-isopropylmalate dehydrogenase activity
WS_RS08540	COG0745	RESPONSE REGULATOR receiver
WS_RS08545	COG0642	Histidine kinase
WS_RS08550	COG0617	tRNA 3'-terminal CCA addition
WS_RS08560	COG0113	porphobilinogen synthase activity
WS_RS08565	COG2823	Periplasmic or secreted lipoprotein
WS_RS08570	COG1280	lysine exporter protein (LysE YggA)
WS_RS08575	COG0628	permease
WS_RS08580	COG2255	four-way junction helicase activity
WS_RS08585	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WS_RS08590	COG0159	tryptophan synthase activity
WS_RS08595	COG1960	acyl-CoA dehydrogenase activity
WS_RS08605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WS_RS08630	COG3260	NADH ubiquinone oxidoreductase 20
WS_RS08635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WS_RS08640	COG3261	NADH dehydrogenase
WS_RS08640	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
WS_RS08645	COG0651	ATP synthesis coupled electron transport
WS_RS08650	COG4237	Hydrogenase 4 membrane
WS_RS08655	COG0650	Formate hydrogenlyase subunit 4
WS_RS08660	COG0651	ATP synthesis coupled electron transport
WS_RS08665	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
WS_RS08675	COG0840	transmembrane signaling receptor activity
WS_RS08675	COG3290	protein histidine kinase activity
WS_RS08680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WS_RS08705	COG1294	oxidase, subunit
WS_RS08710	COG1271	oxidase subunit
WS_RS08735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WS_RS08750	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
WS_RS08770	COG0306	phosphate transporter
WS_RS08775	COG0835	chemotaxis
WS_RS08775	COG0784	Response regulator, receiver
WS_RS08780	COG0157	Belongs to the NadC ModD family
WS_RS08785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WS_RS08790	COG0629	single-stranded DNA binding
WS_RS08795	COG0360	Binds together with S18 to 16S ribosomal RNA
WS_RS08800	COG1466	dna polymerase III delta subunit
WS_RS08805	COG0557	exoribonuclease II activity
WS_RS08815	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WS_RS08820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WS_RS08825	COG2894	cell division
WS_RS08830	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WS_RS08855	COG0138	bifunctional purine biosynthesis protein purh
WS_RS08860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WS_RS08880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WS_RS08895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WS_RS08905	COG0516	GMP reductase activity
WS_RS08905	COG0517	IMP dehydrogenase activity
WS_RS08910	COG0154	amidase activity
WS_RS08915	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WS_RS08920	COG0571	ribonuclease III activity
WS_RS08925	COG0328	RNA-DNA hybrid ribonuclease activity
WS_RS08935	COG0358	DNA primase activity
WS_RS08940	COG0482	sulfurtransferase activity
WS_RS08950	COG0726	polysaccharide deacetylase
WS_RS08975	COG0248	Ppx GppA phosphatase
WS_RS08980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WS_RS08985	COG0134	indole-3-glycerol-phosphate synthase activity
WS_RS08995	COG0727	PFAM Uncharacterised protein family (UPF0153)
WS_RS09000	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WS_RS09010	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WS_RS09020	COG0583	DNA-binding transcription factor activity
WS_RS09025	COG1053	succinate dehydrogenase
WS_RS09030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WS_RS09035	COG2048	Heterodisulfide reductase, subunit B
WS_RS09040	COG0840	transmembrane signaling receptor activity
WS_RS09045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WS_RS09060	COG5002	protein histidine kinase activity
WS_RS09080	COG2801	Transposase and inactivated derivatives
WS_RS09110	COG2046	Belongs to the sulfate adenylyltransferase family
WS_RS09120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WS_RS09120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WS_RS09125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WS_RS09130	COG0489	protein tyrosine kinase activity
WS_RS09135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WS_RS09140	COG2011	ABC-type metal ion transport system permease component
WS_RS09155	COG2860	membrane
WS_RS09160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WS_RS09170	COG0840	transmembrane signaling receptor activity
WS_RS09185	COG0745	RESPONSE REGULATOR receiver
WS_RS09195	COG0840	transmembrane signaling receptor activity
WS_RS09205	COG0840	transmembrane signaling receptor activity
WS_RS09215	COG0556	nucleotide-excision repair
WS_RS09230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WS_RS09240	COG0742	ribosomal rna small subunit methyltransferase
WS_RS09255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WS_RS09265	COG0736	holo-[acyl-carrier-protein] synthase activity
WS_RS09270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WS_RS09275	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WS_RS09280	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
WS_RS09285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WS_RS09290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WS_RS09305	COG1187	pseudouridine synthase activity
WS_RS09310	COG1132	(ABC) transporter
WS_RS09315	COG0784	Response regulator, receiver
WS_RS09315	COG4191	Histidine kinase
WS_RS09325	COG0587	DNA-directed DNA polymerase activity
WS_RS09340	COG0714	Associated with various cellular activities
WS_RS09345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WS_RS09350	COG0416	fatty acid biosynthetic process
WS_RS09355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WS_RS09365	COG0105	UTP biosynthetic process
WS_RS09375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WS_RS09380	COG0450	alkyl hydroperoxide reductase
WS_RS09385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WS_RS09395	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WS_RS09400	COG1766	The M ring may be actively involved in energy transduction
WS_RS09405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WS_RS09415	COG0418	dihydroorotase activity
WS_RS09420	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WS_RS09425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WS_RS09430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WS_RS09440	COG0746	molybdenum cofactor guanylyltransferase activity
WS_RS09450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WS_RS09455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WS_RS09470	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WS_RS09480	COG0083	homoserine kinase activity
WS_RS09485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WS_RS09485	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WS_RS09490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WS_RS09495	COG0779	Required for maturation of 30S ribosomal subunits
WS_RS09500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WS_RS09500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WS_RS09515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WS_RS09520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WS_RS09550	COG0582	viral genome integration into host DNA
WS_RS09595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WS_RS09600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WS_RS09605	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WS_RS09610	COG1160	GTP binding
WS_RS09620	COG0697	spore germination
WS_RS09625	COG0735	belongs to the Fur family
WS_RS09640	COG4191	Histidine kinase
WS_RS09645	COG0745	RESPONSE REGULATOR receiver
WS_RS09650	COG0156	8-amino-7-oxononanoate synthase activity
WS_RS09660	COG0505	Belongs to the CarA family
WS_RS09695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WS_RS09700	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
WS_RS09705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WS_RS09715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WS_RS09720	COG1086	Polysaccharide biosynthesis protein
WS_RS09725	COG0768	penicillin binding
WS_RS09740	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WS_RS09755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WS_RS09760	COG0131	Imidazoleglycerol-phosphate dehydratase
WS_RS09765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WS_RS09770	COG1388	LysM domain
WS_RS09770	COG3584	3D domain protein
WS_RS09775	COG0084	hydrolase, TatD family'
WS_RS09790	COG2257	FlhB HrpN YscU SpaS Family
WS_RS09800	COG0193	aminoacyl-tRNA hydrolase activity
WS_RS09805	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WS_RS09810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WS_RS09815	COG0560	Phosphoserine phosphatase
WS_RS09820	COG0835	chemotaxis
WS_RS09825	COG0643	Histidine kinase
WS_RS09825	COG2198	Histidine kinase
WS_RS09825	COG0784	Response regulator, receiver
WS_RS09830	COG0835	chemotaxis
WS_RS09830	COG0784	Response regulator, receiver
WS_RS09840	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WS_RS09855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WS_RS09865	COG1360	Flagellar Motor Protein
WS_RS09870	COG1338	Plays a role in the flagellum-specific transport system
WS_RS09875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WS_RS09885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WS_RS09890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WS_RS09895	COG0802	atpase or kinase
WS_RS09900	COG1137	ATPase activity
WS_RS09905	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WS_RS09925	COG1610	YqeY-like protein
WS_RS09930	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WS_RS09935	COG1083	cytidylyl-transferase
WS_RS09945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WS_RS09950	COG2089	acid synthase
WS_RS09955	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WS_RS09960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WS_RS09975	COG0840	transmembrane signaling receptor activity
WS_RS09980	COG0564	pseudouridine synthase activity
WS_RS09985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WS_RS09985	COG1519	Transferase
WS_RS09995	COG0752	glycyl-tRNA synthetase alpha subunit
WS_RS10010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WS_RS10015	COG0826	peptidase U32
WS_RS10025	COG0174	glutamine synthetase
WS_RS10030	COG4221	oxidoreductase activity
WS_RS10035	COG1854	S-ribosylhomocysteine lyase activity
WS_RS10045	COG1013	pyruvate-flavodoxin oxidoreductase activity
WS_RS10050	COG0674	pyruvate-flavodoxin oxidoreductase activity
WS_RS10060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WS_RS10065	COG0546	phosphoglycolate phosphatase activity
WS_RS10075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WS_RS10080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WS_RS10090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WS_RS10105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WS_RS10120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WS_RS10125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
WS_RS10130	COG0237	dephospho-CoA kinase activity
WS_RS10135	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WS_RS10145	COG0723	plastoquinol--plastocyanin reductase activity
WS_RS10150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WS_RS10160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WS_RS10170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WS_RS10180	COG1333	cytochrome c biogenesis protein
WS_RS10180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WS_RS10185	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WS_RS10195	COG0137	argininosuccinate synthase activity
WS_RS10215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WS_RS10245	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WS_RS10250	COG2252	PERMEase
WS_RS10255	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
WS_RS10260	COG1213	nucleotidyl transferase
WS_RS10265	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WS_RS10270	COG0574	Belongs to the PEP-utilizing enzyme family
WS_RS10270	COG3848	Pyruvate phosphate dikinase
WS_RS10280	COG0529	Catalyzes the synthesis of activated sulfate
WS_RS10295	COG0367	asparagine synthase
WS_RS10330	COG0367	asparagine synthase
WS_RS10340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WS_RS10355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WS_RS10365	COG2205	protein histidine kinase activity
WS_RS10380	COG0583	DNA-binding transcription factor activity
WS_RS10385	COG2855	membrane
WS_RS10400	COG1157	protein secretion by the type III secretion system
WS_RS10405	COG0544	peptidyl-prolyl cis-trans isomerase activity
WS_RS10410	COG0740	serine-type endopeptidase activity
WS_RS10420	COG0242	peptide deformylase activity
WS_RS10425	COG0606	chelatase, subunit chli
WS_RS10430	COG0488	(ABC) transporter
WS_RS10440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WS_RS10440	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WS_RS10450	COG0167	dihydroorotate dehydrogenase activity
WS_RS10455	COG0612	Peptidase, M16
WS_RS10460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WS_RS10465	COG1028	Short-chain dehydrogenase reductase Sdr
WS_RS10470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WS_RS10475	COG0750	zinc metalloprotease
WS_RS10480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WS_RS10495	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WS_RS10500	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WS_RS10510	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
WS_RS10515	COG0835	chemotaxis
WS_RS10520	COG4943	cyclic-guanylate-specific phosphodiesterase activity
WS_RS10525	COG0438	transferase activity, transferring glycosyl groups
WS_RS10530	COG0745	RESPONSE REGULATOR receiver
WS_RS10535	COG3290	protein histidine kinase activity
WS_RS10535	COG0840	transmembrane signaling receptor activity
WS_RS10555	COG4191	Histidine kinase
WS_RS10570	COG2199	diguanylate cyclase activity
WS_RS10570	COG2200	EAL domain
WS_RS10570	COG3287	FIST C domain
WS_RS10575	COG3706	GGDEF domain
WS_RS10580	COG0840	transmembrane signaling receptor activity
WS_RS10605	COG0840	transmembrane signaling receptor activity
WS_RS10610	COG0726	polysaccharide deacetylase
WS_RS10615	COG3706	GGDEF domain
WS_RS10635	COG0840	transmembrane signaling receptor activity
WS_RS10640	COG0642	Histidine kinase
WS_RS10655	COG4191	Histidine kinase
WS_RS10665	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
WS_RS10685	COG2703	oxygen carrier activity
WS_RS10725	COG2199	diguanylate cyclase activity
WS_RS10725	COG2203	Gaf domain
WS_RS10735	COG1342	Belongs to the UPF0251 family
WS_RS10745	COG3852	Histidine kinase
WS_RS10770	COG2207	Transcriptional regulator
WS_RS10770	COG4753	response regulator
WS_RS10775	COG5001	Diguanylate cyclase
WS_RS10775	COG3300	MHYT domain