locus-tag	class	description
EZH22_RS00025	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_RS00030	COG2814	Major facilitator Superfamily
EZH22_RS00035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZH22_RS00040	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EZH22_RS00045	COG3971	2-oxopent-4-enoate hydratase activity
EZH22_RS00055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_RS00070	COG1355	regulation of microtubule-based process
EZH22_RS00075	COG1414	Transcriptional regulator
EZH22_RS00080	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
EZH22_RS00110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_RS00125	COG2149	membrane
EZH22_RS00145	COG0633	Ferredoxin
EZH22_RS00170	COG1116	anion transmembrane transporter activity
EZH22_RS00175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS00185	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS00190	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EZH22_RS00195	COG0004	ammonium transporteR
EZH22_RS00200	COG3485	protocatechuate 3,4-dioxygenase
EZH22_RS00205	COG3485	protocatechuate 3,4-dioxygenase
EZH22_RS00210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZH22_RS00230	COG1522	sequence-specific DNA binding
EZH22_RS00235	COG2814	Major facilitator Superfamily
EZH22_RS00240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS00245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZH22_RS00260	COG0523	cobalamin synthesis protein
EZH22_RS00270	COG0145	ligase activity
EZH22_RS00275	COG4647	ligase activity
EZH22_RS00280	COG0145	ligase activity
EZH22_RS00310	COG1137	ATPase activity
EZH22_RS00335	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_RS00345	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS00410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EZH22_RS00420	COG1414	Transcriptional regulator
EZH22_RS00425	COG0583	DNA-binding transcription factor activity
EZH22_RS00430	COG0183	Belongs to the thiolase family
EZH22_RS00435	COG0427	acetyl-CoA hydrolase
EZH22_RS00440	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS00445	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
EZH22_RS00450	COG2301	Belongs to the HpcH HpaI aldolase family
EZH22_RS00530	COG3258	Cytochrome c
EZH22_RS00535	COG2010	Cytochrome c
EZH22_RS00545	COG0785	Cytochrome C biogenesis protein
EZH22_RS00560	COG2391	methyltransferase activity
EZH22_RS00600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZH22_RS00605	COG0444	Belongs to the ABC transporter superfamily
EZH22_RS00615	COG0625	glutathione transferase activity
EZH22_RS00625	COG0583	DNA-binding transcription factor activity
EZH22_RS00630	COG0626	cystathionine gamma-synthase activity
EZH22_RS00650	COG0745	RESPONSE REGULATOR receiver
EZH22_RS00655	COG5002	protein histidine kinase activity
EZH22_RS00700	COG1846	Transcriptional regulator
EZH22_RS00735	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS00760	COG0583	DNA-binding transcription factor activity
EZH22_RS00770	COG3971	2-oxopent-4-enoate hydratase activity
EZH22_RS00800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS00820	COG1802	Transcriptional regulator
EZH22_RS00835	COG1116	anion transmembrane transporter activity
EZH22_RS00840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS00855	COG0477	Major facilitator Superfamily
EZH22_RS00875	COG0477	Major facilitator Superfamily
EZH22_RS00880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_RS00900	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS00935	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS00940	COG1126	abc transporter atp-binding protein
EZH22_RS00975	COG1464	Belongs to the NlpA lipoprotein family
EZH22_RS00980	COG2205	protein histidine kinase activity
EZH22_RS00980	COG5002	protein histidine kinase activity
EZH22_RS00980	COG0784	Response regulator, receiver
EZH22_RS00985	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EZH22_RS00990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EZH22_RS00990	COG4651	solute:proton antiporter activity
EZH22_RS01000	COG1121	(ABC) transporter
EZH22_RS01005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EZH22_RS01010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EZH22_RS01020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZH22_RS01030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EZH22_RS01040	COG2514	catechol 2,3-dioxygenase activity
EZH22_RS01055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZH22_RS01055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZH22_RS01065	COG0604	alcohol dehydrogenase
EZH22_RS01075	COG0154	amidase activity
EZH22_RS01090	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_RS01105	COG1116	anion transmembrane transporter activity
EZH22_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS01145	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS01170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZH22_RS01185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EZH22_RS01190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EZH22_RS01200	COG1201	RNA secondary structure unwinding
EZH22_RS01210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EZH22_RS01215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EZH22_RS01235	COG0066	3-isopropylmalate dehydratase activity
EZH22_RS01240	COG3038	cytochrome b561
EZH22_RS01250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EZH22_RS01260	COG1285	pathogenesis
EZH22_RS01270	COG1609	Transcriptional regulator
EZH22_RS01275	COG2084	Dehydrogenase
EZH22_RS01285	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EZH22_RS01290	COG1194	a g-specific adenine glycosylase
EZH22_RS01300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EZH22_RS01310	COG0583	DNA-binding transcription factor activity
EZH22_RS01320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EZH22_RS01335	COG1309	transcriptional regulator
EZH22_RS01355	COG1309	transcriptional regulator
EZH22_RS01360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EZH22_RS01365	COG2011	ABC-type metal ion transport system permease component
EZH22_RS01370	COG1464	Belongs to the NlpA lipoprotein family
EZH22_RS01375	COG4106	trans-aconitate 2-methyltransferase activity
EZH22_RS01380	COG0174	glutamine synthetase
EZH22_RS01410	COG2827	Endonuclease containing a URI domain
EZH22_RS01440	COG1475	DNA binding
EZH22_RS01465	COG5489	Protein of unknown function (DUF736)
EZH22_RS01495	COG1192	Involved in chromosome partitioning
EZH22_RS01540	COG0583	DNA-binding transcription factor activity
EZH22_RS01550	COG0656	L-ascorbic acid biosynthetic process
EZH22_RS01590	COG3451	type IV secretory pathway VirB4
EZH22_RS01610	COG3701	Conjugal transfer protein
EZH22_RS01635	COG0667	Aldo Keto reductase
EZH22_RS01640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_RS01650	COG2072	flavoprotein involved in K transport
EZH22_RS01655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS01660	COG1116	anion transmembrane transporter activity
EZH22_RS01700	COG1045	serine acetyltransferase
EZH22_RS01705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZH22_RS01710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZH22_RS01730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZH22_RS01735	COG0444	Belongs to the ABC transporter superfamily
EZH22_RS01740	COG4608	Belongs to the ABC transporter superfamily
EZH22_RS01745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_RS01755	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS01780	COG1959	2 iron, 2 sulfur cluster binding
EZH22_RS01795	COG1116	anion transmembrane transporter activity
EZH22_RS01800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_RS01805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS01815	COG1053	succinate dehydrogenase
EZH22_RS01835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS01840	COG1116	anion transmembrane transporter activity
EZH22_RS01845	COG1858	cytochrome C peroxidase
EZH22_RS01860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS01865	COG1116	anion transmembrane transporter activity
EZH22_RS01875	COG4974	Belongs to the 'phage' integrase family
EZH22_RS01890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_RS01895	COG0842	Transport permease protein
EZH22_RS01895	COG1129	ABC transporter
EZH22_RS01900	COG0842	Transport permease protein
EZH22_RS01930	COG1309	transcriptional regulator
EZH22_RS01940	COG1845	cytochrome c oxidase, subunit III
EZH22_RS01965	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS01980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_RS01985	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_RS01995	COG0633	Ferredoxin
EZH22_RS02000	COG1522	sequence-specific DNA binding
EZH22_RS02010	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZH22_RS02015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZH22_RS02070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS02115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EZH22_RS02120	COG1487	ribonuclease activity
EZH22_RS02145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZH22_RS02180	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS02185	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS02190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS02195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_RS02235	COG4372	Transposase
EZH22_RS02240	COG3436	PFAM IS66 Orf2 family protein
EZH22_RS02245	COG2963	transposase activity
EZH22_RS02255	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EZH22_RS02260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS02270	COG0604	alcohol dehydrogenase
EZH22_RS02285	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS02310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_RS02325	COG2814	Major facilitator Superfamily
EZH22_RS02330	COG1802	Transcriptional regulator
EZH22_RS02360	COG0583	DNA-binding transcription factor activity
EZH22_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS02385	COG1032	radical SAM domain protein
EZH22_RS02410	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS02420	COG0583	DNA-binding transcription factor activity
EZH22_RS02455	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EZH22_RS02460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS02465	COG1335	isochorismatase
EZH22_RS02470	COG1414	Transcriptional regulator
EZH22_RS02480	COG0477	Major facilitator Superfamily
EZH22_RS02485	COG0028	Belongs to the TPP enzyme family
EZH22_RS02505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_RS02510	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EZH22_RS02515	COG2080	2 iron, 2 sulfur cluster binding
EZH22_RS02525	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EZH22_RS02550	COG0583	DNA-binding transcription factor activity
EZH22_RS02565	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EZH22_RS02575	COG0583	DNA-binding transcription factor activity
EZH22_RS02620	COG0183	Belongs to the thiolase family
EZH22_RS02635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZH22_RS02640	COG4770	biotin carboxylase activity
EZH22_RS02655	COG1024	Enoyl-CoA hydratase
EZH22_RS02660	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS02685	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS02690	COG1022	Amp-dependent synthetase and ligase
EZH22_RS02695	COG1137	ATPase activity
EZH22_RS02715	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS02720	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS02720	COG1024	Enoyl-CoA hydratase
EZH22_RS02735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS02745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_RS02745	COG1116	anion transmembrane transporter activity
EZH22_RS02765	COG0583	DNA-binding transcription factor activity
EZH22_RS02805	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS02820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS02825	COG0583	DNA-binding transcription factor activity
EZH22_RS02845	COG2171	N-acyltransferase activity
EZH22_RS02850	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EZH22_RS02860	COG2186	Transcriptional regulator
EZH22_RS02865	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS02890	COG1131	(ABC) transporter
EZH22_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS02910	COG0277	FAD linked oxidase domain protein
EZH22_RS02930	COG1692	metallophosphoesterase
EZH22_RS02935	COG0217	transcriptional regulatory protein
EZH22_RS02940	COG0789	Transcriptional regulator
EZH22_RS02950	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EZH22_RS02960	COG0632	four-way junction helicase activity
EZH22_RS02970	COG2255	four-way junction helicase activity
EZH22_RS02985	COG0824	Thioesterase
EZH22_RS03005	COG0823	Involved in the tonB-independent uptake of proteins
EZH22_RS03010	COG2885	chlorophyll binding
EZH22_RS03020	COG0037	tRNA processing
EZH22_RS03025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EZH22_RS03055	COG3588	fructose-bisphosphate aldolase
EZH22_RS03060	COG0352	thiamine-phosphate diphosphorylase activity
EZH22_RS03080	COG0024	Methionine aminopeptidase
EZH22_RS03085	COG2003	Belongs to the UPF0758 family
EZH22_RS03100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZH22_RS03105	COG3842	ATPase activity
EZH22_RS03120	COG0395	ABC-type sugar transport system, permease component
EZH22_RS03140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EZH22_RS03140	COG0574	Belongs to the PEP-utilizing enzyme family
EZH22_RS03150	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_RS03155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EZH22_RS03160	COG0045	succinate-CoA ligase (ADP-forming) activity
EZH22_RS03170	COG4191	Histidine kinase
EZH22_RS03175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS03185	COG1802	Transcriptional regulator
EZH22_RS03205	COG1414	Transcriptional regulator
EZH22_RS03210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EZH22_RS03215	COG1238	metal cluster binding
EZH22_RS03225	COG0070	glutamate synthase
EZH22_RS03225	COG0069	glutamate synthase activity
EZH22_RS03225	COG0067	glutamate synthase
EZH22_RS03235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EZH22_RS03255	COG2967	ApaG domain
EZH22_RS03260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EZH22_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS03275	COG2217	Heavy metal translocating P-type atpase
EZH22_RS03290	COG2010	Cytochrome c
EZH22_RS03305	COG3278	Belongs to the heme-copper respiratory oxidase family
EZH22_RS03310	COG0842	Transport permease protein
EZH22_RS03315	COG1131	(ABC) transporter
EZH22_RS03325	COG1309	transcriptional regulator
EZH22_RS03335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_RS03340	COG0728	peptidoglycan biosynthetic process
EZH22_RS03350	COG0673	inositol 2-dehydrogenase activity
EZH22_RS03355	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EZH22_RS03360	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EZH22_RS03365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EZH22_RS03370	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EZH22_RS03375	COG0322	excinuclease ABC activity
EZH22_RS03380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EZH22_RS03390	COG0314	molybdopterin synthase activity
EZH22_RS03395	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS03415	COG0463	Glycosyl transferase, family 2
EZH22_RS03420	COG0589	response to stress
EZH22_RS03430	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EZH22_RS03435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EZH22_RS03455	COG0174	glutamine synthetase
EZH22_RS03460	COG2205	protein histidine kinase activity
EZH22_RS03465	COG0784	Response regulator, receiver
EZH22_RS03470	COG0745	RESPONSE REGULATOR receiver
EZH22_RS03475	COG3411	Ferredoxin
EZH22_RS03480	COG4150	thiosulfate binding
EZH22_RS03485	COG0488	(ABC) transporter
EZH22_RS03500	COG0678	peroxiredoxin activity
EZH22_RS03510	COG1678	Uncharacterized ACR, COG1678
EZH22_RS03515	COG3773	Cell wall hydrolase
EZH22_RS03515	COG3409	Peptidoglycan-binding domain 1 protein
EZH22_RS03520	COG1703	isobutyryl-CoA mutase activity
EZH22_RS03535	COG0473	3-isopropylmalate dehydrogenase activity
EZH22_RS03550	COG0494	nUDIX hydrolase
EZH22_RS03560	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EZH22_RS03570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZH22_RS03580	COG3842	ATPase activity
EZH22_RS03585	COG1177	transmembrane transport
EZH22_RS03590	COG1176	ABC-type spermidine putrescine transport system, permease component I
EZH22_RS03610	COG2368	4-hydroxyphenylacetate
EZH22_RS03615	COG0583	DNA-binding transcription factor activity
EZH22_RS03620	COG3795	YCII-related domain
EZH22_RS03650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZH22_RS03655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZH22_RS03660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EZH22_RS03670	COG1902	pentaerythritol trinitrate reductase activity
EZH22_RS03675	COG0384	phenazine biosynthesis protein PhzF
EZH22_RS03680	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EZH22_RS03690	COG0154	amidase activity
EZH22_RS03700	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EZH22_RS03725	COG2188	Transcriptional regulator
EZH22_RS03730	COG3624	Phosphonate C-P lyase system protein PhnG
EZH22_RS03735	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
EZH22_RS03740	COG3626	phosphonate metabolism
EZH22_RS03750	COG4107	phosphonate C-P lyase system protein PhnK
EZH22_RS03755	COG4778	phosphonate C-P lyase system protein PhnL
EZH22_RS03760	COG3454	Phosphonate metabolism
EZH22_RS03765	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EZH22_RS03785	COG0752	glycyl-tRNA synthetase alpha subunit
EZH22_RS03795	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EZH22_RS03805	COG1573	uracil-dna glycosylase
EZH22_RS03825	COG1525	nuclease
EZH22_RS03830	COG2202	Pas domain
EZH22_RS03830	COG2205	protein histidine kinase activity
EZH22_RS03835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EZH22_RS03840	COG1695	Transcriptional regulator
EZH22_RS03845	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EZH22_RS03860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZH22_RS03870	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZH22_RS03880	COG0567	Dehydrogenase, E1 component
EZH22_RS03885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EZH22_RS03890	COG0045	succinate-CoA ligase (ADP-forming) activity
EZH22_RS03895	COG0039	L-malate dehydrogenase activity
EZH22_RS03915	COG0316	Belongs to the HesB IscA family
EZH22_RS03925	COG0450	alkyl hydroperoxide reductase
EZH22_RS03930	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZH22_RS03950	COG4565	transcriptional regulatory protein
EZH22_RS03955	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
EZH22_RS03960	COG2086	electron transfer activity
EZH22_RS03965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EZH22_RS03970	COG0644	oxidoreductase
EZH22_RS03975	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EZH22_RS03985	COG0412	Dienelactone hydrolase
EZH22_RS04010	COG2346	COG2346, Truncated hemoglobins
EZH22_RS04040	COG2151	metal-sulfur cluster biosynthetic enzyme
EZH22_RS04060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EZH22_RS04075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EZH22_RS04095	COG5554	nitrogen fixation
EZH22_RS04115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EZH22_RS04135	COG1104	cysteine desulfurase activity
EZH22_RS04145	COG0316	Belongs to the HesB IscA family
EZH22_RS04170	COG2897	thiosulfate sulfurtransferase activity
EZH22_RS04195	COG5420	small protein containing a coiled-coil domain
EZH22_RS04210	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EZH22_RS04215	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EZH22_RS04220	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EZH22_RS04230	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
EZH22_RS04235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZH22_RS04240	COG0719	Fe-S assembly protein
EZH22_RS04245	COG0396	ATPase activity
EZH22_RS04250	COG0719	Fe-S assembly protein
EZH22_RS04255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EZH22_RS04270	COG5001	Diguanylate cyclase
EZH22_RS04270	COG1716	ATPase activity
EZH22_RS04275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EZH22_RS04280	COG0756	dUTP diphosphatase activity
EZH22_RS04310	COG0076	glutamate decarboxylase activity
EZH22_RS04315	COG0129	dihydroxy-acid dehydratase activity
EZH22_RS04330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EZH22_RS04345	COG1137	ATPase activity
EZH22_RS04350	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EZH22_RS04355	COG1764	response to oxidative stress
EZH22_RS04360	COG1846	Transcriptional regulator
EZH22_RS04370	COG2205	protein histidine kinase activity
EZH22_RS04380	COG2226	methyltransferase
EZH22_RS04385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EZH22_RS04430	COG0528	UMP kinase activity
EZH22_RS04435	COG0528	UMP kinase activity
EZH22_RS04440	COG0521	Mo-molybdopterin cofactor biosynthetic process
EZH22_RS04445	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EZH22_RS04460	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EZH22_RS04470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EZH22_RS04475	COG1970	mechanosensitive ion channel activity
EZH22_RS04480	COG0167	dihydroorotate dehydrogenase activity
EZH22_RS04485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EZH22_RS04500	COG0137	argininosuccinate synthase activity
EZH22_RS04515	COG2217	Heavy metal translocating P-type atpase
EZH22_RS04545	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS04555	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EZH22_RS04560	COG1122	ATPase activity
EZH22_RS04570	COG0129	dihydroxy-acid dehydratase activity
EZH22_RS04580	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS04585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EZH22_RS04610	COG2814	Major facilitator Superfamily
EZH22_RS04625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZH22_RS04630	COG0564	pseudouridine synthase activity
EZH22_RS04650	COG1196	nuclear chromosome segregation
EZH22_RS04660	COG0356	it plays a direct role in the translocation of protons across the membrane
EZH22_RS04670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EZH22_RS04675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EZH22_RS04705	COG2030	dehydratase
EZH22_RS04715	COG3047	cAMP biosynthetic process
EZH22_RS04720	COG2009	succinate dehydrogenase
EZH22_RS04775	COG3119	arylsulfatase activity
EZH22_RS04780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EZH22_RS04785	COG4977	sequence-specific DNA binding
EZH22_RS04810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EZH22_RS04825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EZH22_RS04830	COG2942	2-epimerase
EZH22_RS04840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EZH22_RS04875	COG1309	transcriptional regulator
EZH22_RS04880	COG1597	lipid kinase activity
EZH22_RS04885	COG1253	flavin adenine dinucleotide binding
EZH22_RS04895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZH22_RS04900	COG0174	glutamine synthetase
EZH22_RS04910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EZH22_RS04920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EZH22_RS04925	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EZH22_RS04930	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EZH22_RS04935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZH22_RS04935	COG0072	phenylalanine-tRNA ligase activity
EZH22_RS04945	COG0006	proline dipeptidase activity
EZH22_RS04965	COG3706	GGDEF domain
EZH22_RS04965	COG2203	Gaf domain
EZH22_RS04965	COG5001	Diguanylate cyclase
EZH22_RS04965	COG4251	negative regulation of phosphorylation
EZH22_RS04975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EZH22_RS04990	COG1741	Belongs to the pirin family
EZH22_RS05000	COG0366	Alpha amylase catalytic
EZH22_RS05010	COG2814	Major facilitator Superfamily
EZH22_RS05030	COG5002	protein histidine kinase activity
EZH22_RS05030	COG2176	DNA-directed DNA polymerase activity
EZH22_RS05035	COG0745	RESPONSE REGULATOR receiver
EZH22_RS05040	COG5002	protein histidine kinase activity
EZH22_RS05060	COG3162	membrane
EZH22_RS05070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_RS05070	COG2080	2 iron, 2 sulfur cluster binding
EZH22_RS05075	COG3224	Antibiotic biosynthesis monooxygenase
EZH22_RS05080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_RS05090	COG0583	DNA-binding transcription factor activity
EZH22_RS05100	COG0656	L-ascorbic acid biosynthetic process
EZH22_RS05110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS05120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_RS05140	COG0583	DNA-binding transcription factor activity
EZH22_RS05165	COG0284	orotidine-5'-phosphate decarboxylase activity
EZH22_RS05170	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS05175	COG0402	S-adenosylhomocysteine deaminase activity
EZH22_RS05190	COG0683	leucine binding
EZH22_RS05195	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS05225	COG1175	transmembrane transport
EZH22_RS05235	COG3842	ATPase activity
EZH22_RS05240	COG1349	DNA-binding transcription factor activity
EZH22_RS05260	COG1024	Enoyl-CoA hydratase
EZH22_RS05260	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS05265	COG0183	Belongs to the thiolase family
EZH22_RS05270	COG1022	Amp-dependent synthetase and ligase
EZH22_RS05305	COG0625	glutathione transferase activity
EZH22_RS05310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EZH22_RS05310	COG0475	glutathione-regulated potassium exporter activity
EZH22_RS05320	COG0582	viral genome integration into host DNA
EZH22_RS05330	COG3152	Membrane
EZH22_RS05375	COG1802	Transcriptional regulator
EZH22_RS05380	COG1072	(Pantothenic acid kinase))
EZH22_RS05385	COG0140	phosphoribosyl-ATP diphosphatase activity
EZH22_RS05390	COG0107	imidazoleglycerol-phosphate synthase activity
EZH22_RS05395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EZH22_RS05400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EZH22_RS05415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZH22_RS05420	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EZH22_RS05425	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EZH22_RS05430	COG2204	response regulator
EZH22_RS05440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZH22_RS05445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZH22_RS05450	COG0493	'glutamate synthase
EZH22_RS05460	COG0523	cobalamin synthesis protein
EZH22_RS05465	COG1686	Belongs to the peptidase S11 family
EZH22_RS05470	COG1132	(ABC) transporter
EZH22_RS05475	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EZH22_RS05480	COG0594	ribonuclease P activity
EZH22_RS05485	COG0706	membrane insertase activity
EZH22_RS05490	COG0156	8-amino-7-oxononanoate synthase activity
EZH22_RS05515	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EZH22_RS05520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EZH22_RS05590	COG0375	protein maturation
EZH22_RS05600	COG2204	response regulator
EZH22_RS05640	COG0539	negative regulation of cytoplasmic translation
EZH22_RS05655	COG5487	UPF0391 membrane protein
EZH22_RS05675	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EZH22_RS05690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZH22_RS05710	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS05720	COG1764	response to oxidative stress
EZH22_RS05740	COG4191	Histidine kinase
EZH22_RS05745	COG4566	intracellular signal transduction
EZH22_RS05765	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EZH22_RS05785	COG3052	prosthetic group binding
EZH22_RS05800	COG0679	Auxin Efflux Carrier
EZH22_RS05805	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_RS05810	COG1802	Transcriptional regulator
EZH22_RS05815	COG0583	DNA-binding transcription factor activity
EZH22_RS05825	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS05835	COG0183	Belongs to the thiolase family
EZH22_RS05850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_RS05855	COG1309	transcriptional regulator
EZH22_RS05875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZH22_RS05880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EZH22_RS05920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS06070	COG3739	integral membrane protein
EZH22_RS06125	COG1522	sequence-specific DNA binding
EZH22_RS06135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_RS06140	COG0842	Transport permease protein
EZH22_RS06140	COG1129	ABC transporter
EZH22_RS06150	COG1959	2 iron, 2 sulfur cluster binding
EZH22_RS06155	COG2917	probably involved in intracellular septation
EZH22_RS06175	COG0745	RESPONSE REGULATOR receiver
EZH22_RS06180	COG0704	Plays a role in the regulation of phosphate uptake
EZH22_RS06185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EZH22_RS06195	COG0573	inorganic phosphate transmembrane transporter activity
EZH22_RS06205	COG5002	protein histidine kinase activity
EZH22_RS06270	COG3158	transport of potassium into the cell
EZH22_RS06275	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EZH22_RS06305	COG1278	Cold shock
EZH22_RS06315	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EZH22_RS06330	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EZH22_RS06335	COG0482	sulfurtransferase activity
EZH22_RS06340	COG2226	methyltransferase
EZH22_RS06365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZH22_RS06370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_RS06380	COG3264	Mechanosensitive ion channel
EZH22_RS06380	COG1196	nuclear chromosome segregation
EZH22_RS06385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZH22_RS06395	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EZH22_RS06415	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS06440	COG0588	phosphoglycerate mutase activity
EZH22_RS06455	COG0284	orotidine-5'-phosphate decarboxylase activity
EZH22_RS06465	COG3963	phosphatidate phosphatase activity
EZH22_RS06480	COG0484	heat shock protein binding
EZH22_RS06490	COG0443	Heat shock 70 kDa protein
EZH22_RS06515	COG4191	Histidine kinase
EZH22_RS06520	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EZH22_RS06535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EZH22_RS06540	COG0792	nuclease activity
EZH22_RS06545	COG0189	ligase activity
EZH22_RS06555	COG2226	methyltransferase
EZH22_RS06580	COG0497	DNA recombination
EZH22_RS06585	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZH22_RS06595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EZH22_RS06600	COG0849	cell division
EZH22_RS06605	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EZH22_RS06615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EZH22_RS06620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EZH22_RS06635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_RS06645	COG3395	kinase activity
EZH22_RS06650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EZH22_RS06680	COG0702	epimerase
EZH22_RS06710	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EZH22_RS06735	COG0436	Aminotransferase
EZH22_RS06755	COG0779	Required for maturation of 30S ribosomal subunits
EZH22_RS06770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EZH22_RS06775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EZH22_RS06780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EZH22_RS06785	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EZH22_RS06790	COG1185	polyribonucleotide nucleotidyltransferase activity
EZH22_RS06825	COG4689	acetoacetate decarboxylase
EZH22_RS06840	COG1607	acyl-coa hydrolase
EZH22_RS06845	COG1643	Atp-dependent helicase
EZH22_RS06850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EZH22_RS06855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EZH22_RS06860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZH22_RS06865	COG0494	nUDIX hydrolase
EZH22_RS06870	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EZH22_RS06900	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EZH22_RS06960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZH22_RS06995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZH22_RS07010	COG0427	acetyl-CoA hydrolase
EZH22_RS07015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EZH22_RS07050	COG1850	ribulose-bisphosphate carboxylase activity
EZH22_RS07060	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EZH22_RS07070	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EZH22_RS07075	COG4149	molybdate abc transporter
EZH22_RS07085	COG1609	Transcriptional regulator
EZH22_RS07110	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS07115	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EZH22_RS07120	COG2086	electron transfer activity
EZH22_RS07140	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EZH22_RS07155	COG0247	lactate metabolic process
EZH22_RS07160	COG1139	Iron-sulfur cluster binding protein
EZH22_RS07165	COG1556	Lactate utilization protein
EZH22_RS07185	COG0583	DNA-binding transcription factor activity
EZH22_RS07190	COG0277	FAD linked oxidase domain protein
EZH22_RS07200	COG0247	lactate metabolic process
EZH22_RS07205	COG0352	thiamine-phosphate diphosphorylase activity
EZH22_RS07210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EZH22_RS07220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EZH22_RS07220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EZH22_RS07225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EZH22_RS07235	COG5001	Diguanylate cyclase
EZH22_RS07235	COG3300	MHYT domain
EZH22_RS07240	COG0045	succinate-CoA ligase (ADP-forming) activity
EZH22_RS07240	COG1042	CoA-binding domain protein
EZH22_RS07240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZH22_RS07245	COG4566	intracellular signal transduction
EZH22_RS07250	COG4566	intracellular signal transduction
EZH22_RS07255	COG4191	Histidine kinase
EZH22_RS07260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZH22_RS07265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EZH22_RS07310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZH22_RS07320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_RS07365	COG0138	bifunctional purine biosynthesis protein purh
EZH22_RS07375	COG1215	transferase activity, transferring glycosyl groups
EZH22_RS07390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZH22_RS07395	COG0165	Argininosuccinate lyase
EZH22_RS07400	COG0019	diaminopimelate decarboxylase activity
EZH22_RS07405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EZH22_RS07410	COG0501	Belongs to the peptidase M48B family
EZH22_RS07420	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
EZH22_RS07450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EZH22_RS07515	COG0702	epimerase
EZH22_RS07555	COG1229	Formylmethanofuran dehydrogenase subunit A
EZH22_RS07575	COG0535	radical SAM domain protein
EZH22_RS07580	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
EZH22_RS07585	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
EZH22_RS07590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EZH22_RS07610	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EZH22_RS07620	COG1968	undecaprenyl-diphosphatase activity
EZH22_RS07630	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EZH22_RS07635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EZH22_RS07645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EZH22_RS07650	COG1253	flavin adenine dinucleotide binding
EZH22_RS07655	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EZH22_RS07660	COG1396	sequence-specific DNA binding
EZH22_RS07665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EZH22_RS07670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EZH22_RS07700	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EZH22_RS07705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EZH22_RS07710	COG1981	membrane
EZH22_RS07715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EZH22_RS07720	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EZH22_RS07725	COG0424	maF-like protein
EZH22_RS07730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EZH22_RS07735	COG0237	dephospho-CoA kinase activity
EZH22_RS07740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EZH22_RS07745	COG1331	Highly conserved protein containing a thioredoxin domain
EZH22_RS07750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EZH22_RS07755	COG0445	tRNA wobble uridine modification
EZH22_RS07760	COG0357	Ribosomal RNA small subunit methyltransferase G
EZH22_RS07780	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EZH22_RS07785	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EZH22_RS07795	COG0436	Aminotransferase
EZH22_RS07800	COG0196	riboflavin kinase activity
EZH22_RS07810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EZH22_RS07820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EZH22_RS07830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EZH22_RS07840	COG0275	rRNA processing
EZH22_RS07845	COG2001	Belongs to the MraZ family
EZH22_RS07855	COG2274	protein secretion by the type I secretion system
EZH22_RS07860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZH22_RS07880	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EZH22_RS07890	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS07910	COG0564	pseudouridine synthase activity
EZH22_RS07920	COG5001	Diguanylate cyclase
EZH22_RS07920	COG3300	MHYT domain
EZH22_RS07930	COG0330	HflC and HflK could
EZH22_RS07960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EZH22_RS07995	COG4181	ATPase activity
EZH22_RS08030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZH22_RS08035	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EZH22_RS08050	COG3023	N-Acetylmuramoyl-L-alanine amidase
EZH22_RS08055	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EZH22_RS08085	COG0542	response to heat
EZH22_RS08105	COG0739	heme binding
EZH22_RS08140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EZH22_RS08140	COG0519	Catalyzes the synthesis of GMP from XMP
EZH22_RS08145	COG0697	spore germination
EZH22_RS08150	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS08165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZH22_RS08165	COG2813	Specifically methylates the guanine in position
EZH22_RS08175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZH22_RS08200	COG0784	Response regulator, receiver
EZH22_RS08210	COG0784	Response regulator, receiver
EZH22_RS08210	COG4191	Histidine kinase
EZH22_RS08235	COG0069	glutamate synthase activity
EZH22_RS08250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZH22_RS08255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EZH22_RS08265	COG3038	cytochrome b561
EZH22_RS08270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZH22_RS08270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZH22_RS08285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EZH22_RS08295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EZH22_RS08300	COG0268	Binds directly to 16S ribosomal RNA
EZH22_RS08310	COG0135	phosphoribosylanthranilate isomerase activity
EZH22_RS08315	COG0133	tryptophan synthase activity
EZH22_RS08325	COG0159	tryptophan synthase activity
EZH22_RS08330	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EZH22_RS08340	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EZH22_RS08345	COG2884	Cell division ATP-binding protein ftsE
EZH22_RS08380	COG3454	Phosphonate metabolism
EZH22_RS08390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EZH22_RS08400	COG0670	Belongs to the BI1 family
EZH22_RS08415	COG0583	DNA-binding transcription factor activity
EZH22_RS08420	COG0837	glucose binding
EZH22_RS08430	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EZH22_RS08460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EZH22_RS08470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EZH22_RS08485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EZH22_RS08490	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EZH22_RS08495	COG0799	negative regulation of ribosome biogenesis
EZH22_RS08500	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EZH22_RS08505	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EZH22_RS08525	COG3750	Belongs to the UPF0335 family
EZH22_RS08530	COG3108	Peptidase M15
EZH22_RS08535	COG2989	Protein conserved in bacteria
EZH22_RS08540	COG3284	Transcriptional regulator
EZH22_RS08555	COG0793	Belongs to the peptidase S41A family
EZH22_RS08560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_RS08565	COG0765	amino acid transport
EZH22_RS08570	COG0765	amino acid transport
EZH22_RS08580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EZH22_RS08585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EZH22_RS08590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EZH22_RS08595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EZH22_RS08605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EZH22_RS08610	COG0590	tRNA wobble adenosine to inosine editing
EZH22_RS08615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZH22_RS08630	COG1116	anion transmembrane transporter activity
EZH22_RS08635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EZH22_RS08645	COG2855	membrane
EZH22_RS08655	COG0488	(ABC) transporter
EZH22_RS08660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EZH22_RS08665	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EZH22_RS08675	COG0509	glycine decarboxylation via glycine cleavage system
EZH22_RS08680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EZH22_RS08690	COG0612	Peptidase, M16
EZH22_RS08695	COG0612	Peptidase, M16
EZH22_RS08705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EZH22_RS08710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EZH22_RS08715	COG0004	ammonium transporteR
EZH22_RS08720	COG0347	Belongs to the P(II) protein family
EZH22_RS08730	COG1946	Acyl-CoA thioesterase
EZH22_RS08735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_RS08740	COG2835	tetraacyldisaccharide 4'-kinase activity
EZH22_RS08745	COG0697	spore germination
EZH22_RS08750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EZH22_RS08765	COG4208	sulfate ABC transporter
EZH22_RS08775	COG0776	regulation of translation
EZH22_RS08780	COG0616	signal peptide processing
EZH22_RS08795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZH22_RS08795	COG2022	thiamine diphosphate biosynthetic process
EZH22_RS08805	COG2022	thiamine diphosphate biosynthetic process
EZH22_RS08810	COG0352	thiamine-phosphate diphosphorylase activity
EZH22_RS08815	COG2183	response to ionizing radiation
EZH22_RS08840	COG1301	dicarboxylic acid transport
EZH22_RS08845	COG4191	Histidine kinase
EZH22_RS08850	COG2204	response regulator
EZH22_RS08855	COG0129	dihydroxy-acid dehydratase activity
EZH22_RS08860	COG0625	glutathione transferase activity
EZH22_RS08875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EZH22_RS08885	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EZH22_RS08890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZH22_RS08895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZH22_RS08900	COG0640	Transcriptional regulator
EZH22_RS08910	COG1393	Belongs to the ArsC family
EZH22_RS08915	COG0798	PFAM Bile acid sodium symporter
EZH22_RS08920	COG0431	NADPH-dependent FMN reductase
EZH22_RS08950	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_RS08960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZH22_RS09000	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EZH22_RS09005	COG0076	glutamate decarboxylase activity
EZH22_RS09015	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS09020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZH22_RS09030	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EZH22_RS09035	COG4670	ketone body catabolic process
EZH22_RS09040	COG1024	Enoyl-CoA hydratase
EZH22_RS09045	COG1053	succinate dehydrogenase
EZH22_RS09045	COG3976	FMN-binding domain protein
EZH22_RS09065	COG1136	(ABC) transporter
EZH22_RS09075	COG1760	l-serine dehydratase
EZH22_RS09085	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZH22_RS09085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EZH22_RS09095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZH22_RS09120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS09125	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EZH22_RS09150	COG2226	methyltransferase
EZH22_RS09185	COG1846	Transcriptional regulator
EZH22_RS09190	COG0410	ABC transporter
EZH22_RS09230	COG2080	2 iron, 2 sulfur cluster binding
EZH22_RS09235	COG2010	Cytochrome c
EZH22_RS09235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_RS09280	COG4566	intracellular signal transduction
EZH22_RS09290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZH22_RS09295	COG4191	Histidine kinase
EZH22_RS09300	COG4566	intracellular signal transduction
EZH22_RS09305	COG2140	Oxalate decarboxylase
EZH22_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS09340	COG4191	Histidine kinase
EZH22_RS09350	COG2223	nitrite transmembrane transporter activity
EZH22_RS09355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZH22_RS09385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_RS09390	COG1802	Transcriptional regulator
EZH22_RS09395	COG0765	amino acid transport
EZH22_RS09400	COG1126	abc transporter atp-binding protein
EZH22_RS09420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZH22_RS09425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZH22_RS09435	COG1414	Transcriptional regulator
EZH22_RS09440	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS09445	COG0183	Belongs to the thiolase family
EZH22_RS09455	COG4829	muconolactone delta-isomerase
EZH22_RS09465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EZH22_RS09490	COG4191	Histidine kinase
EZH22_RS09495	COG4566	intracellular signal transduction
EZH22_RS09505	COG1116	anion transmembrane transporter activity
EZH22_RS09515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZH22_RS09540	COG4988	ABC transporter
EZH22_RS09550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EZH22_RS09555	COG0038	chloride channel
EZH22_RS09560	COG4178	(ABC) transporter
EZH22_RS09570	COG2824	Alkylphosphonate utilization operon protein PhnA
EZH22_RS09575	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS09595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EZH22_RS09605	COG2135	peptidase activity
EZH22_RS09615	COG0546	phosphoglycolate phosphatase activity
EZH22_RS09625	COG1376	ErfK ybiS ycfS ynhG family protein
EZH22_RS09625	COG1388	LysM domain
EZH22_RS09645	COG0259	pyridoxamine-phosphate oxidase activity
EZH22_RS09655	COG0484	heat shock protein binding
EZH22_RS09660	COG2030	dehydratase
EZH22_RS09685	COG1024	Enoyl-CoA hydratase
EZH22_RS09695	COG0730	response to heat
EZH22_RS09715	COG3237	CsbD-like
EZH22_RS09720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EZH22_RS09725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EZH22_RS09730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EZH22_RS09735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EZH22_RS09765	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS09770	COG1802	Transcriptional regulator
EZH22_RS09785	COG1129	ABC transporter
EZH22_RS09790	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS09795	COG3246	L-lysine catabolic process to acetate
EZH22_RS09810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EZH22_RS09835	COG0335	large ribosomal subunit rRNA binding
EZH22_RS09840	COG0336	Belongs to the RNA methyltransferase TrmD family
EZH22_RS09845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EZH22_RS09865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZH22_RS09870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_RS09875	COG0277	FAD linked oxidase domain protein
EZH22_RS09880	COG2271	Major facilitator Superfamily
EZH22_RS09885	COG2208	phosphoserine phosphatase activity
EZH22_RS09885	COG2770	Histidine kinase
EZH22_RS09935	COG1366	Belongs to the anti-sigma-factor antagonist family
EZH22_RS09940	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EZH22_RS09945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EZH22_RS09960	COG1420	regulation of RNA biosynthetic process
EZH22_RS09965	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EZH22_RS09970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EZH22_RS09975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EZH22_RS09980	COG1160	GTP binding
EZH22_RS09995	COG1671	Belongs to the UPF0178 family
EZH22_RS10000	COG0671	phosphoesterase, PA-phosphatase related
EZH22_RS10020	COG1496	oxidoreductase activity
EZH22_RS10050	COG0617	tRNA 3'-terminal CCA addition
EZH22_RS10065	COG0640	Transcriptional regulator
EZH22_RS10095	COG3047	cAMP biosynthetic process
EZH22_RS10105	COG1063	alcohol dehydrogenase
EZH22_RS10195	COG1309	transcriptional regulator
EZH22_RS10210	COG2267	carboxylic ester hydrolase activity
EZH22_RS10225	COG0427	acetyl-CoA hydrolase
EZH22_RS10230	COG3246	L-lysine catabolic process to acetate
EZH22_RS10235	COG2072	flavoprotein involved in K transport
EZH22_RS10255	COG1024	Enoyl-CoA hydratase
EZH22_RS10265	COG1024	Enoyl-CoA hydratase
EZH22_RS10290	COG1137	ATPase activity
EZH22_RS10300	COG1024	Enoyl-CoA hydratase
EZH22_RS10310	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS10315	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS10320	COG2030	dehydratase
EZH22_RS10325	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS10340	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS10350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS10355	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS10360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS10365	COG2186	Transcriptional regulator
EZH22_RS10370	COG2186	Transcriptional regulator
EZH22_RS10400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS10440	COG3485	protocatechuate 3,4-dioxygenase
EZH22_RS10445	COG3485	protocatechuate 3,4-dioxygenase
EZH22_RS10450	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZH22_RS10455	COG0583	DNA-binding transcription factor activity
EZH22_RS10500	COG1024	Enoyl-CoA hydratase
EZH22_RS10530	COG0667	Aldo Keto reductase
EZH22_RS10535	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS10560	COG2963	transposase activity
EZH22_RS10585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZH22_RS10590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_RS10595	COG0386	Belongs to the glutathione peroxidase family
EZH22_RS10610	COG1283	sodium-dependent phosphate transmembrane transporter activity
EZH22_RS10615	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EZH22_RS10635	COG0647	UMP catabolic process
EZH22_RS10640	COG1737	Transcriptional regulator
EZH22_RS10675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZH22_RS10680	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_RS10705	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EZH22_RS10745	COG4372	Transposase
EZH22_RS10750	COG3436	PFAM IS66 Orf2 family protein
EZH22_RS10755	COG2963	transposase activity
EZH22_RS10770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EZH22_RS10840	COG0582	viral genome integration into host DNA
EZH22_RS10850	COG1024	Enoyl-CoA hydratase
EZH22_RS10855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EZH22_RS10865	COG0242	peptide deformylase activity
EZH22_RS10870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EZH22_RS10875	COG0101	tRNA pseudouridine synthase activity
EZH22_RS10890	COG0778	Nitroreductase
EZH22_RS10900	COG4221	oxidoreductase activity
EZH22_RS10905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EZH22_RS10920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EZH22_RS10955	COG0071	Belongs to the small heat shock protein (HSP20) family
EZH22_RS10960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZH22_RS10980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_RS11000	COG2226	methyltransferase
EZH22_RS11035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_RS11075	COG1999	signal sequence binding
EZH22_RS11090	COG0679	Auxin Efflux Carrier
EZH22_RS11095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EZH22_RS11105	COG0400	carboxylic ester hydrolase activity
EZH22_RS11140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EZH22_RS11145	COG1846	Transcriptional regulator
EZH22_RS11150	COG0745	RESPONSE REGULATOR receiver
EZH22_RS11160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZH22_RS11170	COG2818	Glycosylase
EZH22_RS11185	COG2890	protein-(glutamine-N5) methyltransferase activity
EZH22_RS11190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EZH22_RS11200	COG0527	aspartate kinase activity
EZH22_RS11210	COG2816	NAD+ diphosphatase activity
EZH22_RS11230	COG3474	cytochrome
EZH22_RS11235	COG4166	transmembrane transport
EZH22_RS11245	COG4174	ABC transporter (Permease)
EZH22_RS11250	COG4239	(ABC) transporter, permease
EZH22_RS11255	COG4172	Belongs to the ABC transporter superfamily
EZH22_RS11260	COG0494	nUDIX hydrolase
EZH22_RS11400	COG3842	ATPase activity
EZH22_RS11405	COG1176	ABC-type spermidine putrescine transport system, permease component I
EZH22_RS11410	COG1177	transmembrane transport
EZH22_RS11435	COG0714	Associated with various cellular activities
EZH22_RS11455	COG0617	tRNA 3'-terminal CCA addition
EZH22_RS11475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EZH22_RS11485	COG0723	plastoquinol--plastocyanin reductase activity
EZH22_RS11490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EZH22_RS11490	COG2857	Cytochrome c1
EZH22_RS11495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EZH22_RS11495	COG2857	Cytochrome c1
EZH22_RS11505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EZH22_RS11520	COG3706	GGDEF domain
EZH22_RS11535	COG2983	Belongs to the UPF0260 family
EZH22_RS11565	COG1217	gtp-binding protein TYPA
EZH22_RS11570	COG2084	Dehydrogenase
EZH22_RS11575	COG3622	Belongs to the hyi family
EZH22_RS11580	COG3960	tartronate-semialdehyde synthase activity
EZH22_RS11590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EZH22_RS11595	COG0450	alkyl hydroperoxide reductase
EZH22_RS11600	COG3620	sequence-specific DNA binding
EZH22_RS11600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EZH22_RS11600	COG0617	tRNA 3'-terminal CCA addition
EZH22_RS11645	COG1609	Transcriptional regulator
EZH22_RS11690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZH22_RS11715	COG2081	HI0933 family
EZH22_RS11725	COG0469	pyruvate kinase activity
EZH22_RS11730	COG2954	triphosphatase activity
EZH22_RS11750	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS11755	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS11760	COG1024	Enoyl-CoA hydratase
EZH22_RS11820	COG0436	Aminotransferase
EZH22_RS11830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EZH22_RS11835	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EZH22_RS11840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZH22_RS11865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZH22_RS11870	COG4957	zinc ion binding
EZH22_RS11875	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EZH22_RS11895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EZH22_RS11930	COG1475	DNA binding
EZH22_RS11960	COG5489	Protein of unknown function (DUF736)
EZH22_RS11965	COG1396	sequence-specific DNA binding
EZH22_RS11985	COG1192	Involved in chromosome partitioning
EZH22_RS12005	COG0739	heme binding
EZH22_RS12005	COG1196	nuclear chromosome segregation
EZH22_RS12005	COG0741	lytic transglycosylase activity
EZH22_RS12070	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EZH22_RS12095	COG4962	Type ii secretion system protein e
EZH22_RS12110	COG3451	type IV secretory pathway VirB4
EZH22_RS12130	COG3701	Conjugal transfer protein
EZH22_RS12140	COG2948	multi-organism process
EZH22_RS12150	COG0583	DNA-binding transcription factor activity
EZH22_RS12155	COG2301	Belongs to the HpcH HpaI aldolase family
EZH22_RS12165	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS12215	COG0583	DNA-binding transcription factor activity
EZH22_RS12235	COG4974	Belongs to the 'phage' integrase family
EZH22_RS12255	COG1053	succinate dehydrogenase
EZH22_RS12255	COG3976	FMN-binding domain protein
EZH22_RS12260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS12270	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS12305	COG0583	DNA-binding transcription factor activity
EZH22_RS12320	COG2706	6-phosphogluconolactonase activity
EZH22_RS12325	COG3177	Filamentation induced by cAMP protein fic
EZH22_RS12335	COG0583	DNA-binding transcription factor activity
EZH22_RS12360	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS12370	COG4336	lyase activity
EZH22_RS12375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EZH22_RS12375	COG0519	Catalyzes the synthesis of GMP from XMP
EZH22_RS12410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS12420	COG0183	Belongs to the thiolase family
EZH22_RS12425	COG1024	Enoyl-CoA hydratase
EZH22_RS12425	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS12450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS12460	COG0747	negative chemotaxis
EZH22_RS12465	COG0601	transmembrane transport
EZH22_RS12470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZH22_RS12485	COG0667	Aldo Keto reductase
EZH22_RS12490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_RS12495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_RS12515	COG1116	anion transmembrane transporter activity
EZH22_RS12520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS12525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_RS12540	COG1136	(ABC) transporter
EZH22_RS12585	COG2030	dehydratase
EZH22_RS12590	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS12595	COG2050	protein possibly involved in aromatic compounds catabolism
EZH22_RS12600	COG1309	transcriptional regulator
EZH22_RS12605	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS12610	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EZH22_RS12630	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS12630	COG1024	Enoyl-CoA hydratase
EZH22_RS12635	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS12640	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS12670	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS12675	COG1024	Enoyl-CoA hydratase
EZH22_RS12680	COG1024	Enoyl-CoA hydratase
EZH22_RS12685	COG0604	alcohol dehydrogenase
EZH22_RS12690	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS12695	COG1846	Transcriptional regulator
EZH22_RS12705	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS12710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EZH22_RS12715	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS12720	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS12725	COG0183	Belongs to the thiolase family
EZH22_RS12750	COG3976	FMN-binding domain protein
EZH22_RS12750	COG1053	succinate dehydrogenase
EZH22_RS12750	COG0431	NADPH-dependent FMN reductase
EZH22_RS12785	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS12815	COG2084	Dehydrogenase
EZH22_RS12825	COG1902	pentaerythritol trinitrate reductase activity
EZH22_RS12825	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZH22_RS12840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_RS12870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS12890	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS12900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_RS12910	COG2368	4-hydroxyphenylacetate
EZH22_RS12935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS12940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS12990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EZH22_RS13010	COG1522	sequence-specific DNA binding
EZH22_RS13015	COG2199	diguanylate cyclase activity
EZH22_RS13015	COG2203	Gaf domain
EZH22_RS13020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_RS13035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS13040	COG1116	anion transmembrane transporter activity
EZH22_RS13045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS13050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_RS13055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_RS13070	COG0646	methionine synthase
EZH22_RS13070	COG1410	methionine synthase
EZH22_RS13075	COG1376	ErfK ybiS ycfS ynhG family protein
EZH22_RS13090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EZH22_RS13095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EZH22_RS13125	COG2351	hydroxyisourate hydrolase activity
EZH22_RS13130	COG2233	PERMEase
EZH22_RS13135	COG0583	DNA-binding transcription factor activity
EZH22_RS13150	COG2205	protein histidine kinase activity
EZH22_RS13155	COG3178	'Phosphotransferase
EZH22_RS13160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EZH22_RS13170	COG1074	ATP-dependent DNA helicase activity
EZH22_RS13180	COG0579	oxidoreductase
EZH22_RS13185	COG3842	ATPase activity
EZH22_RS13190	COG1178	ABC-type Fe3 transport system permease component
EZH22_RS13200	COG0028	Belongs to the TPP enzyme family
EZH22_RS13205	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS13210	COG2030	dehydratase
EZH22_RS13220	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EZH22_RS13225	COG0583	DNA-binding transcription factor activity
EZH22_RS13240	COG0577	efflux transmembrane transporter activity
EZH22_RS13240	COG1136	(ABC) transporter
EZH22_RS13245	COG2205	protein histidine kinase activity
EZH22_RS13255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS13270	COG0242	peptide deformylase activity
EZH22_RS13290	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS13295	COG3453	Protein conserved in bacteria
EZH22_RS13295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZH22_RS13325	COG0488	(ABC) transporter
EZH22_RS13335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EZH22_RS13340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EZH22_RS13350	COG1024	Enoyl-CoA hydratase
EZH22_RS13355	COG2084	Dehydrogenase
EZH22_RS13360	COG1902	pentaerythritol trinitrate reductase activity
EZH22_RS13365	COG1309	transcriptional regulator
EZH22_RS13370	COG4670	ketone body catabolic process
EZH22_RS13390	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EZH22_RS13395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS13400	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS13405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_RS13410	COG1136	(ABC) transporter
EZH22_RS13410	COG0577	efflux transmembrane transporter activity
EZH22_RS13415	COG0577	efflux transmembrane transporter activity
EZH22_RS13420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_RS13425	COG3321	synthase
EZH22_RS13425	COG0604	alcohol dehydrogenase
EZH22_RS13425	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS13440	COG2010	Cytochrome c
EZH22_RS13450	COG2951	lytic endotransglycosylase activity
EZH22_RS13455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EZH22_RS13475	COG0287	Prephenate dehydrogenase
EZH22_RS13480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZH22_RS13510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EZH22_RS13530	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EZH22_RS13545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EZH22_RS13550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EZH22_RS13555	COG0552	protein localization to endoplasmic reticulum
EZH22_RS13580	COG2943	transferase activity, transferring hexosyl groups
EZH22_RS13595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EZH22_RS13600	COG0583	DNA-binding transcription factor activity
EZH22_RS13605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EZH22_RS13610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EZH22_RS13625	COG0861	Integral membrane protein TerC family
EZH22_RS13630	COG0861	Integral membrane protein TerC family
EZH22_RS13635	COG0105	UTP biosynthetic process
EZH22_RS13645	COG0667	Aldo Keto reductase
EZH22_RS13655	COG2030	dehydratase
EZH22_RS13665	COG0012	GTP binding
EZH22_RS13670	COG0193	aminoacyl-tRNA hydrolase activity
EZH22_RS13675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EZH22_RS13680	COG3258	Cytochrome c
EZH22_RS13690	COG1309	transcriptional regulator
EZH22_RS13705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EZH22_RS13720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_RS13725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS13730	COG1116	anion transmembrane transporter activity
EZH22_RS13730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_RS13735	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EZH22_RS13740	COG0778	Nitroreductase
EZH22_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS13760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EZH22_RS13760	COG1648	precorrin-2 dehydrogenase activity
EZH22_RS13765	COG0251	oxidation-reduction process
EZH22_RS13775	COG0246	Mannitol dehydrogenase
EZH22_RS13780	COG1904	glucuronate isomerase
EZH22_RS13790	COG2721	sulfolactate sulfo-lyase activity
EZH22_RS13795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZH22_RS13810	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EZH22_RS13815	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS13825	COG1872	DUF167
EZH22_RS13835	COG0825	malonyl-CoA metabolic process
EZH22_RS13840	COG3034	peptidoglycan biosynthetic process
EZH22_RS13850	COG0653	protein targeting
EZH22_RS13855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_RS13870	COG2308	Evidence 4 Homologs of previously reported genes of
EZH22_RS13870	COG2307	Protein conserved in bacteria
EZH22_RS13875	COG1305	Transglutaminase-like
EZH22_RS13880	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS13890	COG2186	Transcriptional regulator
EZH22_RS13895	COG0745	RESPONSE REGULATOR receiver
EZH22_RS13910	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZH22_RS13910	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZH22_RS13920	COG3852	Histidine kinase
EZH22_RS13940	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EZH22_RS13955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_RS13965	COG4608	Belongs to the ABC transporter superfamily
EZH22_RS13970	COG0444	Belongs to the ABC transporter superfamily
EZH22_RS13980	COG0601	transmembrane transport
EZH22_RS13985	COG4166	transmembrane transport
EZH22_RS14150	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS14165	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS14175	COG1122	ATPase activity
EZH22_RS14190	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS14195	COG1024	Enoyl-CoA hydratase
EZH22_RS14215	COG2030	dehydratase
EZH22_RS14225	COG1137	ATPase activity
EZH22_RS14255	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZH22_RS14260	COG1024	Enoyl-CoA hydratase
EZH22_RS14265	COG0022	dehydrogenase e1 component
EZH22_RS14270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EZH22_RS14280	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS14315	COG2207	Transcriptional regulator
EZH22_RS14335	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS14340	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS14350	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS14355	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS14370	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_RS14385	COG1309	transcriptional regulator
EZH22_RS14390	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS14395	COG0183	Belongs to the thiolase family
EZH22_RS14415	COG0411	ABC transporter
EZH22_RS14425	COG0667	Aldo Keto reductase
EZH22_RS14430	COG0534	Mate efflux family protein
EZH22_RS14445	COG0174	glutamine synthetase
EZH22_RS14450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EZH22_RS14450	COG0519	Catalyzes the synthesis of GMP from XMP
EZH22_RS14460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZH22_RS14465	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS14485	COG2205	protein histidine kinase activity
EZH22_RS14490	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EZH22_RS14495	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EZH22_RS14505	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EZH22_RS14545	COG3327	negative regulation of DNA-templated transcription, initiation
EZH22_RS14550	COG3396	Phenylacetate-CoA oxygenase
EZH22_RS14555	COG3460	Phenylacetate-CoA oxygenase
EZH22_RS14560	COG3396	Phenylacetate-CoA oxygenase
EZH22_RS14565	COG2151	metal-sulfur cluster biosynthetic enzyme
EZH22_RS14570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZH22_RS14580	COG2050	protein possibly involved in aromatic compounds catabolism
EZH22_RS14585	COG1024	Enoyl-CoA hydratase
EZH22_RS14595	COG0183	Belongs to the thiolase family
EZH22_RS14605	COG2030	dehydratase
EZH22_RS14605	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS14615	COG2814	Major facilitator Superfamily
EZH22_RS14620	COG0583	DNA-binding transcription factor activity
EZH22_RS14665	COG0650	Formate hydrogenlyase subunit 4
EZH22_RS14675	COG0651	ATP synthesis coupled electron transport
EZH22_RS14680	COG3261	NADH dehydrogenase
EZH22_RS14680	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
EZH22_RS14685	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZH22_RS14690	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS14695	COG3284	Transcriptional regulator
EZH22_RS14735	COG0154	amidase activity
EZH22_RS14745	COG2368	4-hydroxyphenylacetate
EZH22_RS14750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_RS14780	COG0175	sulfate reduction
EZH22_RS14790	COG0556	nucleotide-excision repair
EZH22_RS14815	COG2133	pyrroloquinoline quinone binding
EZH22_RS14825	COG0625	glutathione transferase activity
EZH22_RS14830	COG0436	Aminotransferase
EZH22_RS14850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EZH22_RS14870	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EZH22_RS14875	COG0625	glutathione transferase activity
EZH22_RS14890	COG0500	methyltransferase
EZH22_RS14900	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EZH22_RS14905	COG0424	maF-like protein
EZH22_RS14915	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EZH22_RS14915	COG1618	nucleotide phosphatase activity, acting on free nucleotides
EZH22_RS14920	COG2271	Major facilitator Superfamily
EZH22_RS14940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EZH22_RS14945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZH22_RS14950	COG1522	sequence-specific DNA binding
EZH22_RS14955	COG0492	ferredoxin-NADP+ reductase activity
EZH22_RS14970	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
EZH22_RS15000	COG1921	L-seryl-tRNASec selenium transferase activity
EZH22_RS15010	COG2864	formate dehydrogenase
EZH22_RS15015	COG0437	4 iron, 4 sulfur cluster binding
EZH22_RS15025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZH22_RS15035	COG0709	Synthesizes selenophosphate from selenide and ATP
EZH22_RS15050	COG1063	alcohol dehydrogenase
EZH22_RS15075	COG2610	gluconate transmembrane transporter activity
EZH22_RS15080	COG0786	glutamate:sodium symporter activity
EZH22_RS15100	COG0151	Belongs to the GarS family
EZH22_RS15105	COG1570	exodeoxyribonuclease VII activity
EZH22_RS15115	COG1663	tetraacyldisaccharide 4'-kinase activity
EZH22_RS15140	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EZH22_RS15150	COG0028	Belongs to the TPP enzyme family
EZH22_RS15160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EZH22_RS15165	COG0716	FMN binding
EZH22_RS15180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EZH22_RS15190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EZH22_RS15205	COG3321	synthase
EZH22_RS15205	COG0604	alcohol dehydrogenase
EZH22_RS15205	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS15220	COG0254	rRNA binding
EZH22_RS15225	COG1132	(ABC) transporter
EZH22_RS15255	COG0673	inositol 2-dehydrogenase activity
EZH22_RS15260	COG3842	ATPase activity
EZH22_RS15280	COG0129	dihydroxy-acid dehydratase activity
EZH22_RS15300	COG2201	protein-glutamate methylesterase activity
EZH22_RS15310	COG4178	(ABC) transporter
EZH22_RS15315	COG1278	Cold shock
EZH22_RS15335	COG3459	Glycosyltransferase 36 associated
EZH22_RS15355	COG0583	DNA-binding transcription factor activity
EZH22_RS15365	COG0625	glutathione transferase activity
EZH22_RS15380	COG0583	DNA-binding transcription factor activity
EZH22_RS15415	COG0281	malic enzyme
EZH22_RS15435	COG0277	FAD linked oxidase domain protein
EZH22_RS15455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_RS15455	COG2010	Cytochrome c
EZH22_RS15495	COG3842	ATPase activity
EZH22_RS15500	COG0243	molybdopterin cofactor binding
EZH22_RS15530	COG0477	Major facilitator Superfamily
EZH22_RS15540	COG1376	ErfK ybiS ycfS ynhG family protein
EZH22_RS15540	COG1388	LysM domain
EZH22_RS15560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EZH22_RS15560	COG0519	Catalyzes the synthesis of GMP from XMP
EZH22_RS15655	COG0154	amidase activity
EZH22_RS15660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_RS15670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS15675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_RS15695	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS15700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZH22_RS15745	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EZH22_RS15765	COG0420	3'-5' exonuclease activity
EZH22_RS15785	COG2373	Large extracellular alpha-helical protein
EZH22_RS15790	COG4953	penicillin-binding protein 1C
EZH22_RS15805	COG0582	viral genome integration into host DNA
EZH22_RS15845	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS15860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS15865	COG0183	Belongs to the thiolase family
EZH22_RS15880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_RS15890	COG3386	PFAM SMP-30 Gluconolaconase
EZH22_RS15895	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS15910	COG4232	protein-disulfide reductase activity
EZH22_RS15920	COG1376	ErfK ybiS ycfS ynhG family protein
EZH22_RS15920	COG1388	LysM domain
EZH22_RS15935	COG0765	amino acid transport
EZH22_RS15940	COG0765	amino acid transport
EZH22_RS15945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_RS15950	COG1414	Transcriptional regulator
EZH22_RS15965	COG0765	amino acid transport
EZH22_RS15970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_RS15985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZH22_RS15990	COG0235	Class ii aldolase
EZH22_RS16010	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS16020	COG1404	Belongs to the peptidase S8 family
EZH22_RS16060	COG0604	alcohol dehydrogenase
EZH22_RS16080	COG0577	efflux transmembrane transporter activity
EZH22_RS16085	COG1136	(ABC) transporter
EZH22_RS16115	COG1032	radical SAM domain protein
EZH22_RS16160	COG0583	DNA-binding transcription factor activity
EZH22_RS16175	COG1414	Transcriptional regulator
EZH22_RS16185	COG0477	Major facilitator Superfamily
EZH22_RS16190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EZH22_RS16210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EZH22_RS16225	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EZH22_RS16235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EZH22_RS16240	COG0081	regulation of translation
EZH22_RS16245	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EZH22_RS16250	COG0222	ribosome binding
EZH22_RS16255	COG0085	RNA polymerase activity
EZH22_RS16260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EZH22_RS16270	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
EZH22_RS16315	COG0142	geranyltranstransferase activity
EZH22_RS16345	COG1742	UPF0060 membrane protein
EZH22_RS16350	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EZH22_RS16365	COG0183	Belongs to the thiolase family
EZH22_RS16380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EZH22_RS16395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EZH22_RS16400	COG4208	sulfate ABC transporter
EZH22_RS16405	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EZH22_RS16415	COG0175	sulfate reduction
EZH22_RS16425	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EZH22_RS16435	COG1024	Enoyl-CoA hydratase
EZH22_RS16455	COG1137	ATPase activity
EZH22_RS16460	COG0410	ABC transporter
EZH22_RS16465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZH22_RS16470	COG0358	DNA primase activity
EZH22_RS16480	COG0505	Belongs to the CarA family
EZH22_RS16490	COG1802	Transcriptional regulator
EZH22_RS16500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS16520	COG0166	Belongs to the GPI family
EZH22_RS16525	COG0363	glucosamine-6-phosphate deaminase activity
EZH22_RS16530	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EZH22_RS16535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EZH22_RS16545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EZH22_RS16580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EZH22_RS16585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZH22_RS16590	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS16595	COG2321	neutral zinc metallopeptidase
EZH22_RS16600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EZH22_RS16605	COG1294	oxidase, subunit
EZH22_RS16610	COG1271	oxidase subunit
EZH22_RS16615	COG0443	Heat shock 70 kDa protein
EZH22_RS16620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_RS16630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS16645	COG2132	Multicopper oxidase
EZH22_RS16660	COG2902	Dehydrogenase
EZH22_RS16710	COG1024	Enoyl-CoA hydratase
EZH22_RS16710	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS16715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZH22_RS16725	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS16745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EZH22_RS16755	COG3135	benzoate transporter
EZH22_RS16765	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EZH22_RS16800	COG0248	Ppx GppA phosphatase
EZH22_RS16805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EZH22_RS16815	COG0628	permease
EZH22_RS16825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EZH22_RS16835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZH22_RS16840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZH22_RS16850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EZH22_RS16855	COG1561	YicC-like family, N-terminal region
EZH22_RS16860	COG0194	GDP metabolic process
EZH22_RS16865	COG3161	chorismate lyase activity
EZH22_RS16900	COG4695	Portal protein
EZH22_RS16925	COG0741	lytic transglycosylase activity
EZH22_RS17060	COG2095	MarC family integral membrane protein
EZH22_RS17070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZH22_RS17095	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS17105	COG0346	lactoylglutathione lyase activity
EZH22_RS17115	COG0602	queuosine metabolic process
EZH22_RS17120	COG0720	synthase
EZH22_RS17125	COG0431	NADPH-dependent FMN reductase
EZH22_RS17145	COG2132	Multicopper oxidase
EZH22_RS17155	COG0672	)-iron permease
EZH22_RS17165	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EZH22_RS17170	COG4149	molybdate abc transporter
EZH22_RS17175	COG0725	ABC transporter, periplasmic molybdate-binding protein
EZH22_RS17180	COG0586	Pfam SNARE associated Golgi protein
EZH22_RS17185	COG0513	Belongs to the DEAD box helicase family
EZH22_RS17205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS17210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_RS17215	COG1278	Cold shock
EZH22_RS17220	COG1376	ErfK ybiS ycfS ynhG family protein
EZH22_RS17225	COG2267	carboxylic ester hydrolase activity
EZH22_RS17240	COG3685	Protein conserved in bacteria
EZH22_RS17265	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_RS17270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS17295	COG0546	phosphoglycolate phosphatase activity
EZH22_RS17305	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EZH22_RS17315	COG1216	Glycosyl transferase, family 2
EZH22_RS17315	COG0438	transferase activity, transferring glycosyl groups
EZH22_RS17325	COG2814	Major facilitator Superfamily
EZH22_RS17340	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EZH22_RS17355	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS17375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_RS17385	COG5265	(ABC) transporter
EZH22_RS17415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZH22_RS17430	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EZH22_RS17435	COG3383	formate dehydrogenase (NAD+) activity
EZH22_RS17450	COG0583	DNA-binding transcription factor activity
EZH22_RS17500	COG0387	Pfam Sodium calcium exchanger
EZH22_RS17505	COG0010	Belongs to the arginase family
EZH22_RS17510	COG3706	GGDEF domain
EZH22_RS17530	COG0745	RESPONSE REGULATOR receiver
EZH22_RS17540	COG0436	Aminotransferase
EZH22_RS17555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EZH22_RS17580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZH22_RS17585	COG4770	biotin carboxylase activity
EZH22_RS17590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZH22_RS17595	COG3800	Transcriptional regulator
EZH22_RS17595	COG1396	sequence-specific DNA binding
EZH22_RS17625	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EZH22_RS17640	COG0215	cysteine-tRNA ligase activity
EZH22_RS17650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZH22_RS17655	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EZH22_RS17670	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS17680	COG1309	transcriptional regulator
EZH22_RS17705	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EZH22_RS17715	COG2423	ornithine cyclodeaminase activity
EZH22_RS17725	COG0145	ligase activity
EZH22_RS17730	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
EZH22_RS17735	COG4647	ligase activity
EZH22_RS17740	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EZH22_RS17760	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EZH22_RS17770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EZH22_RS17775	COG0560	Phosphoserine phosphatase
EZH22_RS17795	COG0330	HflC and HflK could
EZH22_RS17800	COG0330	HflC and HflK could
EZH22_RS17815	COG0114	fumarate hydratase activity
EZH22_RS17825	COG1704	LemA family
EZH22_RS17830	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EZH22_RS17845	COG0039	L-malate dehydrogenase activity
EZH22_RS17855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EZH22_RS17860	COG0049	tRNA binding
EZH22_RS17865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EZH22_RS17870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EZH22_RS17875	COG0051	transcription antitermination factor activity, RNA binding
EZH22_RS17880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EZH22_RS17885	COG0088	Forms part of the polypeptide exit tunnel
EZH22_RS17890	COG0089	rRNA binding
EZH22_RS17895	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EZH22_RS17900	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EZH22_RS17905	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EZH22_RS17910	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EZH22_RS17915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EZH22_RS17920	COG0255	Belongs to the universal ribosomal protein uL29 family
EZH22_RS17925	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EZH22_RS17930	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EZH22_RS17935	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EZH22_RS17940	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EZH22_RS17945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EZH22_RS17950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EZH22_RS17955	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EZH22_RS17960	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EZH22_RS17965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EZH22_RS17970	COG1841	ribosomal large subunit assembly
EZH22_RS17975	COG0200	Binds to the 23S rRNA
EZH22_RS17980	COG0201	protein transport
EZH22_RS17985	COG0563	adenylate kinase activity
EZH22_RS17990	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EZH22_RS17995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EZH22_RS18000	COG0202	RNA polymerase activity
EZH22_RS18005	COG0203	ribosomal protein L17
EZH22_RS18010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZH22_RS18015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EZH22_RS18025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EZH22_RS18045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZH22_RS18070	COG0513	Belongs to the DEAD box helicase family
EZH22_RS18085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EZH22_RS18090	COG2610	gluconate transmembrane transporter activity
EZH22_RS18095	COG1192	Involved in chromosome partitioning
EZH22_RS18120	COG1494	fructose-1,6-bisphosphatase
EZH22_RS18130	COG0436	Aminotransferase
EZH22_RS18140	COG3243	poly(R)-hydroxyalkanoic acid synthase
EZH22_RS18150	COG0612	Peptidase, M16
EZH22_RS18160	COG1393	Belongs to the ArsC family
EZH22_RS18225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS18230	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS18235	COG0183	Belongs to the thiolase family
EZH22_RS18250	COG0688	phosphatidylethanolamine metabolic process
EZH22_RS18260	COG0747	negative chemotaxis
EZH22_RS18265	COG0601	transmembrane transport
EZH22_RS18270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZH22_RS18295	COG1802	Transcriptional regulator
EZH22_RS18305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EZH22_RS18320	COG0537	adenosine 5'-monophosphoramidase activity
EZH22_RS18325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EZH22_RS18340	COG2308	Evidence 4 Homologs of previously reported genes of
EZH22_RS18345	COG1058	Belongs to the CinA family
EZH22_RS18345	COG1546	Belongs to the CinA family
EZH22_RS18395	COG1088	dTDP-glucose 4,6-dehydratase activity
EZH22_RS18400	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EZH22_RS18405	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EZH22_RS18410	COG2199	diguanylate cyclase activity
EZH22_RS18410	COG2200	EAL domain
EZH22_RS18410	COG2202	Pas domain
EZH22_RS18415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EZH22_RS18420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EZH22_RS18425	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EZH22_RS18430	COG2945	thiolester hydrolase activity
EZH22_RS18435	COG1104	cysteine desulfurase activity
EZH22_RS18440	COG0719	Fe-S assembly protein
EZH22_RS18445	COG0396	ATPase activity
EZH22_RS18455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZH22_RS18460	COG2151	metal-sulfur cluster biosynthetic enzyme
EZH22_RS18480	COG0442	prolyl-tRNA aminoacylation
EZH22_RS18490	COG1136	(ABC) transporter
EZH22_RS18525	COG1396	sequence-specific DNA binding
EZH22_RS18540	COG0395	ABC-type sugar transport system, permease component
EZH22_RS18565	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS18570	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS18570	COG1024	Enoyl-CoA hydratase
EZH22_RS18575	COG0183	Belongs to the thiolase family
EZH22_RS18585	COG2067	long-chain fatty acid transport protein
EZH22_RS18590	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS18595	COG0052	Belongs to the universal ribosomal protein uS2 family
EZH22_RS18600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EZH22_RS18605	COG0528	UMP kinase activity
EZH22_RS18610	COG0233	cytoplasmic translational termination
EZH22_RS18615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EZH22_RS18625	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EZH22_RS18630	COG0750	zinc metalloprotease
EZH22_RS18635	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZH22_RS18645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EZH22_RS18650	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EZH22_RS18655	COG3494	Protein of unknown function (DUF1009)
EZH22_RS18665	COG0372	Belongs to the citrate synthase family
EZH22_RS18670	COG0746	molybdenum cofactor guanylyltransferase activity
EZH22_RS18695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EZH22_RS18700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZH22_RS18710	COG2832	Protein of unknown function (DUF454)
EZH22_RS18715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EZH22_RS18720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZH22_RS18735	COG1472	Belongs to the glycosyl hydrolase 3 family
EZH22_RS18740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EZH22_RS18745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EZH22_RS18750	COG3842	ATPase activity
EZH22_RS18755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZH22_RS18760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZH22_RS18765	COG0805	protein transport
EZH22_RS18770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EZH22_RS18775	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EZH22_RS18780	COG1862	Preprotein translocase
EZH22_RS18785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZH22_RS18795	COG3737	Protein of unknown function (DUF498/DUF598)
EZH22_RS18810	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EZH22_RS18825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EZH22_RS18835	COG0629	single-stranded DNA binding
EZH22_RS18845	COG1280	lysine exporter protein (LysE YggA)
EZH22_RS18850	COG0514	ATP-dependent DNA helicase (RecQ)
EZH22_RS18855	COG3609	addiction module antidote protein, CC2985 family
EZH22_RS18865	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EZH22_RS18870	COG0154	amidase activity
EZH22_RS18875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EZH22_RS18895	COG2239	Acts as a magnesium transporter
EZH22_RS18905	COG5001	Diguanylate cyclase
EZH22_RS18915	COG2154	pterin-4-alpha-carbinolamine dehydratase
EZH22_RS18925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EZH22_RS18930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZH22_RS18940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZH22_RS18950	COG1509	lysine 2,3-aminomutase activity
EZH22_RS18960	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EZH22_RS18960	COG3608	succinylglutamate desuccinylase aspartoacylase
EZH22_RS18965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EZH22_RS18985	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EZH22_RS18995	COG0477	Major facilitator Superfamily
EZH22_RS19000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EZH22_RS19005	COG0758	DNA mediated transformation
EZH22_RS19010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EZH22_RS19015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZH22_RS19020	COG0540	Belongs to the ATCase OTCase family
EZH22_RS19035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EZH22_RS19045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EZH22_RS19045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EZH22_RS19060	COG2204	response regulator
EZH22_RS19065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EZH22_RS19105	COG1254	Belongs to the acylphosphatase family
EZH22_RS19115	COG0456	acetyltransferase
EZH22_RS19120	COG0625	glutathione transferase activity
EZH22_RS19155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EZH22_RS19170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EZH22_RS19180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EZH22_RS19185	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EZH22_RS19190	COG0047	phosphoribosylformylglycinamidine synthase activity
EZH22_RS19200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EZH22_RS19215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EZH22_RS19225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EZH22_RS19235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EZH22_RS19245	COG0784	Response regulator, receiver
EZH22_RS19250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EZH22_RS19270	COG0557	exoribonuclease II activity
EZH22_RS19300	COG2301	Belongs to the HpcH HpaI aldolase family
EZH22_RS19310	COG0679	Auxin Efflux Carrier
EZH22_RS19315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_RS19320	COG0861	Integral membrane protein TerC family
EZH22_RS19325	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS19340	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EZH22_RS19345	COG0736	holo-[acyl-carrier-protein] synthase activity
EZH22_RS19350	COG0681	Belongs to the peptidase S26 family
EZH22_RS19360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EZH22_RS19375	COG1131	(ABC) transporter
EZH22_RS19405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EZH22_RS19420	COG0406	alpha-ribazole phosphatase activity
EZH22_RS19430	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EZH22_RS19445	COG0477	Major facilitator Superfamily
EZH22_RS19460	COG2239	Acts as a magnesium transporter
EZH22_RS19475	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS19495	COG0829	nickel cation binding
EZH22_RS19505	COG0831	urea catabolic process
EZH22_RS19505	COG0832	Belongs to the urease beta subunit family
EZH22_RS19515	COG0804	urea catabolic process
EZH22_RS19520	COG0783	Belongs to the Dps family
EZH22_RS19525	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EZH22_RS19530	COG0830	nickel cation binding
EZH22_RS19535	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EZH22_RS19555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EZH22_RS19565	COG0438	transferase activity, transferring glycosyl groups
EZH22_RS19575	COG0156	8-amino-7-oxononanoate synthase activity
EZH22_RS19580	COG0604	alcohol dehydrogenase
EZH22_RS19580	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS19580	COG3321	synthase
EZH22_RS19600	COG0110	maltose O-acetyltransferase activity
EZH22_RS19620	COG0438	transferase activity, transferring glycosyl groups
EZH22_RS19625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EZH22_RS19630	COG0438	transferase activity, transferring glycosyl groups
EZH22_RS19685	COG1696	Membrane protein involved in D-alanine export
EZH22_RS19700	COG0316	Belongs to the HesB IscA family
EZH22_RS19705	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EZH22_RS19710	COG0018	arginyl-trna synthetase
EZH22_RS19730	COG0730	response to heat
EZH22_RS19735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EZH22_RS19740	COG1902	pentaerythritol trinitrate reductase activity
EZH22_RS19750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZH22_RS19755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_RS19770	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_RS19785	COG3842	ATPase activity
EZH22_RS19790	COG1176	ABC-type spermidine putrescine transport system, permease component I
EZH22_RS19795	COG1177	transmembrane transport
EZH22_RS19835	COG0671	phosphoesterase, PA-phosphatase related
EZH22_RS19840	COG0463	Glycosyl transferase, family 2
EZH22_RS19850	COG0626	cystathionine gamma-synthase activity
EZH22_RS19855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_RS19860	COG4597	amino acid ABC transporter
EZH22_RS19865	COG0765	amino acid transport
EZH22_RS19870	COG1126	abc transporter atp-binding protein
EZH22_RS19880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EZH22_RS19895	COG1686	Belongs to the peptidase S11 family
EZH22_RS19905	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EZH22_RS19940	COG0174	glutamine synthetase
EZH22_RS19945	COG0347	Belongs to the P(II) protein family
EZH22_RS19970	COG0628	permease
EZH22_RS19975	COG1309	transcriptional regulator
EZH22_RS19980	COG3246	L-lysine catabolic process to acetate
EZH22_RS20015	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS20030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZH22_RS20035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_RS20040	COG0673	inositol 2-dehydrogenase activity
EZH22_RS20060	COG2084	Dehydrogenase
EZH22_RS20070	COG1802	Transcriptional regulator
EZH22_RS20110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_RS20110	COG2010	Cytochrome c
EZH22_RS20115	COG2080	2 iron, 2 sulfur cluster binding
EZH22_RS20120	COG2084	Dehydrogenase
EZH22_RS20135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EZH22_RS20140	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS20145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS20150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS20165	COG1802	Transcriptional regulator
EZH22_RS20175	COG0523	cobalamin synthesis protein
EZH22_RS20185	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EZH22_RS20190	COG0148	phosphopyruvate hydratase activity
EZH22_RS20195	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS20200	COG2095	MarC family integral membrane protein
EZH22_RS20205	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EZH22_RS20215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EZH22_RS20220	COG0113	porphobilinogen synthase activity
EZH22_RS20225	COG1024	Enoyl-CoA hydratase
EZH22_RS20235	COG4122	O-methyltransferase activity
EZH22_RS20245	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS20255	COG0134	indole-3-glycerol-phosphate synthase activity
EZH22_RS20280	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EZH22_RS20285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EZH22_RS20295	COG0459	protein refolding
EZH22_RS20300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EZH22_RS20305	COG5425	PFAM Usg family protein
EZH22_RS20310	COG0693	protein deglycase activity
EZH22_RS20325	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EZH22_RS20330	COG0343	queuine tRNA-ribosyltransferase activity
EZH22_RS20335	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS20355	COG0848	biopolymer transport protein
EZH22_RS20365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EZH22_RS20370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EZH22_RS20375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZH22_RS20375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZH22_RS20385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EZH22_RS20390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EZH22_RS20395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EZH22_RS20410	COG0544	peptidyl-prolyl cis-trans isomerase activity
EZH22_RS20415	COG0740	serine-type endopeptidase activity
EZH22_RS20420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EZH22_RS20425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EZH22_RS20430	COG0776	regulation of translation
EZH22_RS20450	COG0400	carboxylic ester hydrolase activity
EZH22_RS20455	COG0346	lactoylglutathione lyase activity
EZH22_RS20480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_RS20485	COG1116	anion transmembrane transporter activity
EZH22_RS20490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS20500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_RS20520	COG1840	ABC-type Fe3 transport system, periplasmic component
EZH22_RS20580	COG1492	cobalamin metabolic process
EZH22_RS20610	COG3768	UPF0283 membrane protein
EZH22_RS20615	COG3106	COG3106 Predicted ATPase
EZH22_RS20635	COG3191	aminopeptidase activity
EZH22_RS20640	COG0785	Cytochrome C biogenesis protein
EZH22_RS20660	COG0416	fatty acid biosynthetic process
EZH22_RS20665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZH22_RS20670	COG0776	regulation of translation
EZH22_RS20675	COG3956	TIGRFAM MazG family protein
EZH22_RS20690	COG0321	lipoyl(octanoyl) transferase activity
EZH22_RS20690	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EZH22_RS20710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EZH22_RS20720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EZH22_RS20725	COG1923	regulation of RNA biosynthetic process
EZH22_RS20730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EZH22_RS20740	COG0569	domain protein
EZH22_RS20745	COG2204	response regulator
EZH22_RS20750	COG5000	phosphorelay sensor kinase activity
EZH22_RS20755	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EZH22_RS20775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EZH22_RS20790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EZH22_RS20795	COG0134	indole-3-glycerol-phosphate synthase activity
EZH22_RS20805	COG0315	cyclic pyranopterin monophosphate synthase activity
EZH22_RS20810	COG0303	'Molybdopterin
EZH22_RS20815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EZH22_RS20830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EZH22_RS20840	COG1473	amidohydrolase
EZH22_RS20850	COG0457	Tetratricopeptide repeat
EZH22_RS20870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZH22_RS20895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_RS20915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EZH22_RS20935	COG0628	permease
EZH22_RS20955	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EZH22_RS20960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EZH22_RS20975	COG1024	Enoyl-CoA hydratase
EZH22_RS20990	COG1612	heme a metabolic process
EZH22_RS20995	COG1346	cytolysis
EZH22_RS21000	COG1380	Effector of murein hydrolase LrgA
EZH22_RS21005	COG0583	DNA-binding transcription factor activity
EZH22_RS21015	COG1832	CoA-binding protein
EZH22_RS21020	COG0084	hydrolase, TatD family'
EZH22_RS21045	COG0470	DNA polymerase III
EZH22_RS21050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EZH22_RS21055	COG1686	Belongs to the peptidase S11 family
EZH22_RS21080	COG0655	NAD(P)H dehydrogenase (quinone) activity
EZH22_RS21115	COG4221	oxidoreductase activity
EZH22_RS21130	COG4221	oxidoreductase activity
EZH22_RS21170	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
EZH22_RS21185	COG5383	Protein conserved in bacteria
EZH22_RS21195	COG2264	protein methyltransferase activity
EZH22_RS21200	COG0583	DNA-binding transcription factor activity
EZH22_RS21215	COG0543	2 iron, 2 sulfur cluster binding
EZH22_RS21215	COG0633	Ferredoxin
EZH22_RS21220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EZH22_RS21265	COG3852	Histidine kinase
EZH22_RS21295	COG1309	transcriptional regulator
EZH22_RS21300	COG4608	Belongs to the ABC transporter superfamily
EZH22_RS21305	COG0444	Belongs to the ABC transporter superfamily
EZH22_RS21315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZH22_RS21320	COG0747	negative chemotaxis
EZH22_RS21345	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EZH22_RS21360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZH22_RS21385	COG3263	regulation of cellular component size
EZH22_RS21400	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EZH22_RS21405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EZH22_RS21430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EZH22_RS21435	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EZH22_RS21440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZH22_RS21445	COG4558	Periplasmic binding protein
EZH22_RS21450	COG4771	TonB-dependent receptor
EZH22_RS21455	COG2329	Antibiotic biosynthesis monooxygenase
EZH22_RS21475	COG3795	YCII-related domain
EZH22_RS21480	COG4941	Belongs to the sigma-70 factor family
EZH22_RS21490	COG5265	(ABC) transporter
EZH22_RS21560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EZH22_RS21625	COG3617	BRO family, N-terminal domain
EZH22_RS21630	COG4974	Belongs to the 'phage' integrase family
EZH22_RS21645	COG1002	Type II restriction enzyme, methylase subunits
EZH22_RS21730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS21750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_RS21770	COG2186	Transcriptional regulator
EZH22_RS21790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_RS21800	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS21825	COG1126	abc transporter atp-binding protein
EZH22_RS21830	COG0765	amino acid transport
EZH22_RS21865	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS21895	COG0633	Ferredoxin
EZH22_RS21900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS21915	COG1309	transcriptional regulator
EZH22_RS21930	COG0183	Belongs to the thiolase family
EZH22_RS21940	COG1024	Enoyl-CoA hydratase
EZH22_RS21990	COG0683	leucine binding
EZH22_RS21995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EZH22_RS22000	COG2867	negative regulation of translational initiation
EZH22_RS22005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EZH22_RS22015	COG2261	transglycosylase associated protein
EZH22_RS22020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZH22_RS22035	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZH22_RS22040	COG0022	dehydrogenase e1 component
EZH22_RS22040	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZH22_RS22050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EZH22_RS22060	COG1381	Involved in DNA repair and RecF pathway recombination
EZH22_RS22075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EZH22_RS22135	COG3246	L-lysine catabolic process to acetate
EZH22_RS22205	COG1414	Transcriptional regulator
EZH22_RS22210	COG1744	ABC transporter substrate-binding protein PnrA-like
EZH22_RS22215	COG3845	ABC transporter
EZH22_RS22220	COG3845	ABC transporter
EZH22_RS22230	COG1079	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS22235	COG4607	ABC-type enterochelin transport system periplasmic component
EZH22_RS22245	COG4605	iron ion homeostasis
EZH22_RS22250	COG4604	ABC transporter, ATP-binding protein
EZH22_RS22260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_RS22265	COG1136	(ABC) transporter
EZH22_RS22265	COG0577	efflux transmembrane transporter activity
EZH22_RS22270	COG1535	isochorismatase
EZH22_RS22270	COG3433	isochorismatase activity
EZH22_RS22280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZH22_RS22285	COG1169	isochorismate synthase
EZH22_RS22290	COG1021	2,3-dihydroxybenzoate-AMP ligase
EZH22_RS22295	COG3433	isochorismatase activity
EZH22_RS22295	COG1535	isochorismatase
EZH22_RS22300	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS22310	COG4774	siderophore transport
EZH22_RS22325	COG0243	molybdopterin cofactor binding
EZH22_RS22330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_RS22350	COG1129	ABC transporter
EZH22_RS22355	COG1137	ATPase activity
EZH22_RS22360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZH22_RS22415	COG3220	belongs to the UPF0276 family
EZH22_RS22455	COG2948	multi-organism process
EZH22_RS22470	COG3846	protein secretion by the type IV secretion system
EZH22_RS22485	COG3451	type IV secretory pathway VirB4
EZH22_RS22500	COG4962	Type ii secretion system protein e
EZH22_RS22520	COG0741	lytic transglycosylase activity
EZH22_RS22545	COG1192	Involved in chromosome partitioning
EZH22_RS22580	COG5489	Protein of unknown function (DUF736)
EZH22_RS22630	COG4227	nucleotidyltransferase activity
EZH22_RS22655	COG0420	3'-5' exonuclease activity
EZH22_RS22660	COG0419	ATPase involved in DNA repair
EZH22_RS22665	COG0419	ATPase involved in DNA repair
EZH22_RS22670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EZH22_RS22685	COG0556	nucleotide-excision repair
EZH22_RS22725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EZH22_RS22760	COG1132	(ABC) transporter
EZH22_RS22770	COG2346	COG2346, Truncated hemoglobins
EZH22_RS22775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZH22_RS22790	COG0525	valine-tRNA ligase activity
EZH22_RS22810	COG2076	Multidrug Resistance protein
EZH22_RS22820	COG0504	CTP synthase activity
EZH22_RS22830	COG2252	PERMEase
EZH22_RS22835	COG0739	heme binding
EZH22_RS22845	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EZH22_RS22850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EZH22_RS22855	COG1758	RNA polymerase activity
EZH22_RS22865	COG1573	uracil-dna glycosylase
EZH22_RS22880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EZH22_RS22890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_RS22895	COG0741	lytic transglycosylase activity
EZH22_RS22900	COG0633	Ferredoxin
EZH22_RS22925	COG1127	ABC transporter
EZH22_RS22930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EZH22_RS22935	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_RS22950	COG0438	transferase activity, transferring glycosyl groups
EZH22_RS22965	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_RS22970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EZH22_RS23010	COG1530	ribonuclease E activity
EZH22_RS23010	COG1530	ribonuclease E activity
EZH22_RS23015	COG0860	N-Acetylmuramoyl-L-alanine amidase
EZH22_RS23020	COG1335	isochorismatase
EZH22_RS23030	COG2079	MmgE PrpD family protein
EZH22_RS23055	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
EZH22_RS23060	COG2301	Belongs to the HpcH HpaI aldolase family
EZH22_RS23065	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_RS23070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS23080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_RS23110	COG0538	isocitrate dehydrogenase activity
EZH22_RS23115	COG0297	glycogen (starch) synthase activity
EZH22_RS23120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZH22_RS23135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EZH22_RS23140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EZH22_RS23165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EZH22_RS23170	COG0477	Major facilitator Superfamily
EZH22_RS23175	COG0415	Belongs to the DNA photolyase family
EZH22_RS23180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EZH22_RS23185	COG2897	thiosulfate sulfurtransferase activity
EZH22_RS23190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EZH22_RS23190	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EZH22_RS23275	COG0110	maltose O-acetyltransferase activity
EZH22_RS23300	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EZH22_RS23320	COG3206	protein involved in exopolysaccharide biosynthesis
EZH22_RS23320	COG0489	protein tyrosine kinase activity
EZH22_RS23345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EZH22_RS23360	COG0356	it plays a direct role in the translocation of protons across the membrane
EZH22_RS23420	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_RS23425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZH22_RS23430	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_RS23435	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_RS23440	COG3181	Tripartite tricarboxylate transporter family receptor
EZH22_RS23445	COG1802	Transcriptional regulator
EZH22_RS23460	COG1132	(ABC) transporter
EZH22_RS23480	COG1566	PFAM secretion protein HlyD family protein
EZH22_RS23500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS23505	COG0154	amidase activity
EZH22_RS23535	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EZH22_RS23540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZH22_RS23555	COG3634	alkyl hydroperoxide reductase activity
EZH22_RS23575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_RS23580	COG4303	Ethanolamine ammonia lyase large subunit
EZH22_RS23585	COG4302	ethanolamine ammonia-lyase activity
EZH22_RS23635	COG0438	transferase activity, transferring glycosyl groups
EZH22_RS23650	COG3436	PFAM IS66 Orf2 family protein
EZH22_RS23675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EZH22_RS23685	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EZH22_RS23700	COG0438	transferase activity, transferring glycosyl groups
EZH22_RS23710	COG4372	Transposase
EZH22_RS23715	COG3436	PFAM IS66 Orf2 family protein
EZH22_RS23720	COG2963	transposase activity
EZH22_RS23745	COG2963	transposase activity
EZH22_RS23750	COG3436	PFAM IS66 Orf2 family protein
EZH22_RS23775	COG0316	Belongs to the HesB IscA family
EZH22_RS23780	COG5001	Diguanylate cyclase
EZH22_RS23780	COG3300	MHYT domain
EZH22_RS23790	COG0346	lactoylglutathione lyase activity
EZH22_RS23805	COG1007	ATP synthesis coupled electron transport
EZH22_RS23820	COG0713	ATP synthesis coupled electron transport
EZH22_RS23830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZH22_RS23835	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EZH22_RS23850	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EZH22_RS23860	COG0649	NAD binding
EZH22_RS23865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZH22_RS23870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZH22_RS23880	COG3064	Membrane
EZH22_RS23900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EZH22_RS23930	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EZH22_RS23940	COG0109	protoheme IX farnesyltransferase activity
EZH22_RS23945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EZH22_RS23950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EZH22_RS23960	COG0475	glutathione-regulated potassium exporter activity
EZH22_RS23960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EZH22_RS23975	COG0583	DNA-binding transcription factor activity
EZH22_RS23980	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EZH22_RS24005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_RS24090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EZH22_RS24100	COG1278	Cold shock
EZH22_RS24150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZH22_RS24200	COG0656	L-ascorbic acid biosynthetic process
EZH22_RS24205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EZH22_RS24210	COG0583	DNA-binding transcription factor activity
EZH22_RS24215	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS24245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS24250	COG1116	anion transmembrane transporter activity
EZH22_RS24305	COG0714	Associated with various cellular activities
EZH22_RS24320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_RS24325	COG4993	Dehydrogenase
EZH22_RS24560	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EZH22_RS24735	COG0675	Transposase, IS605 OrfB family
EZH22_RS24800	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EZH22_RS24810	COG0069	glutamate synthase activity
EZH22_RS24830	COG0583	DNA-binding transcription factor activity
EZH22_RS24835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZH22_RS24845	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZH22_RS24845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EZH22_RS24880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EZH22_RS24885	COG0803	Belongs to the bacterial solute-binding protein 9 family
EZH22_RS24890	COG0523	cobalamin synthesis protein
EZH22_RS24895	COG0800	Aldolase
EZH22_RS24910	COG0511	ligase activity, forming carbon-carbon bonds
EZH22_RS24915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EZH22_RS24950	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EZH22_RS24980	COG0583	DNA-binding transcription factor activity
EZH22_RS24990	COG2205	protein histidine kinase activity
EZH22_RS24990	COG2202	Pas domain
EZH22_RS25005	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EZH22_RS25015	COG0745	RESPONSE REGULATOR receiver
EZH22_RS25020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZH22_RS25025	COG3088	subunit of a heme lyase
EZH22_RS25030	COG1138	Cytochrome C-type biogenesis protein
EZH22_RS25035	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EZH22_RS25040	COG4235	cytochrome complex assembly
EZH22_RS25070	COG0411	ABC transporter
EZH22_RS25090	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZH22_RS25095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EZH22_RS25125	COG2358	TRAP transporter, solute receptor (TAXI family
EZH22_RS25130	COG2080	2 iron, 2 sulfur cluster binding
EZH22_RS25135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EZH22_RS25140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_RS25155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZH22_RS25160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZH22_RS25165	COG1120	ATPase activity
EZH22_RS25170	COG4774	siderophore transport
EZH22_RS25205	COG1132	(ABC) transporter
EZH22_RS25220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EZH22_RS25225	COG1120	ATPase activity
EZH22_RS25230	COG4774	siderophore transport
EZH22_RS25290	COG4608	Belongs to the ABC transporter superfamily
EZH22_RS25300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZH22_RS25305	COG0601	transmembrane transport
EZH22_RS25310	COG0747	negative chemotaxis
EZH22_RS25325	COG2271	Major facilitator Superfamily
EZH22_RS25330	COG0066	3-isopropylmalate dehydratase activity
EZH22_RS25335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EZH22_RS25340	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_RS25345	COG0583	DNA-binding transcription factor activity
EZH22_RS25420	COG1137	ATPase activity
EZH22_RS25445	COG0243	molybdopterin cofactor binding
EZH22_RS25460	COG0582	viral genome integration into host DNA
EZH22_RS25480	COG0433	COG0433 Predicted ATPase
EZH22_RS25505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EZH22_RS25520	COG0726	polysaccharide deacetylase
EZH22_RS25525	COG0235	Class ii aldolase
EZH22_RS25530	COG2084	Dehydrogenase
EZH22_RS25545	COG1522	sequence-specific DNA binding
EZH22_RS25550	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EZH22_RS25550	COG2066	Belongs to the glutaminase family
EZH22_RS25590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS25610	COG1414	Transcriptional regulator
EZH22_RS25620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZH22_RS25625	COG0583	DNA-binding transcription factor activity
EZH22_RS25630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EZH22_RS25635	COG1228	amidohydrolase
EZH22_RS25655	COG4603	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS25675	COG2223	nitrite transmembrane transporter activity
EZH22_RS25685	COG1140	nitrate reductase beta subunit
EZH22_RS25690	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EZH22_RS25695	COG2181	nitrate reductase activity
EZH22_RS25700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZH22_RS25710	COG0288	reversible hydration of carbon dioxide
EZH22_RS25740	COG1082	Xylose isomerase domain protein TIM barrel
EZH22_RS25740	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EZH22_RS25750	COG3962	Belongs to the TPP enzyme family
EZH22_RS25755	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EZH22_RS25760	COG0045	succinate-CoA ligase (ADP-forming) activity
EZH22_RS25765	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS25770	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS25775	COG0583	DNA-binding transcription factor activity
EZH22_RS25800	COG0395	ABC-type sugar transport system, permease component
EZH22_RS25805	COG1175	transmembrane transport
EZH22_RS25815	COG3842	ATPase activity
EZH22_RS25825	COG0277	FAD linked oxidase domain protein
EZH22_RS25845	COG2032	superoxide dismutase activity
EZH22_RS25850	COG1609	Transcriptional regulator
EZH22_RS25855	COG0300	oxidoreductase activity
EZH22_RS25860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS25885	COG1175	transmembrane transport
EZH22_RS25900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EZH22_RS25930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS25940	COG0583	DNA-binding transcription factor activity
EZH22_RS25945	COG0154	amidase activity
EZH22_RS25950	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EZH22_RS25975	COG0583	DNA-binding transcription factor activity
EZH22_RS25980	COG0402	S-adenosylhomocysteine deaminase activity
EZH22_RS25985	COG0154	amidase activity
EZH22_RS25995	COG1733	regulation of RNA biosynthetic process
EZH22_RS26000	COG1335	isochorismatase
EZH22_RS26015	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EZH22_RS26030	COG5001	Diguanylate cyclase
EZH22_RS26030	COG3300	MHYT domain
EZH22_RS26050	COG2205	protein histidine kinase activity
EZH22_RS26060	COG0280	phosphate acetyltransferase
EZH22_RS26060	COG0281	malic enzyme
EZH22_RS26085	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EZH22_RS26090	COG2166	iron-sulfur cluster assembly
EZH22_RS26115	COG5328	Belongs to the UPF0262 family
EZH22_RS26125	COG5001	Diguanylate cyclase
EZH22_RS26125	COG3300	MHYT domain
EZH22_RS26140	COG0628	permease
EZH22_RS26160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EZH22_RS26165	COG3665	Urea carboxylase-associated protein
EZH22_RS26170	COG3665	Urea carboxylase-associated protein
EZH22_RS26240	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
EZH22_RS26245	COG1797	cobyrinic acid a,c-diamide synthase activity
EZH22_RS26265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZH22_RS26270	COG0842	Transport permease protein
EZH22_RS26275	COG1131	(ABC) transporter
EZH22_RS26295	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS26300	COG0009	L-threonylcarbamoyladenylate synthase
EZH22_RS26305	COG0456	acetyltransferase
EZH22_RS26310	COG0123	including yeast histone deacetylase and acetoin utilization protein
EZH22_RS26335	COG0574	Belongs to the PEP-utilizing enzyme family
EZH22_RS26335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EZH22_RS26345	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EZH22_RS26360	COG2351	hydroxyisourate hydrolase activity
EZH22_RS26385	COG3181	Tripartite tricarboxylate transporter family receptor
EZH22_RS26390	COG0583	DNA-binding transcription factor activity
EZH22_RS26405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZH22_RS26410	COG0628	permease
EZH22_RS26430	COG0210	DNA helicase
EZH22_RS26450	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EZH22_RS26465	COG1793	dna ligase
EZH22_RS26465	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EZH22_RS26475	COG1793	dna ligase
EZH22_RS26475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EZH22_RS26495	COG0534	Mate efflux family protein
EZH22_RS26515	COG0228	four-way junction DNA binding
EZH22_RS26520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EZH22_RS26555	COG0657	acetylesterase activity
EZH22_RS26560	COG0432	Pfam Uncharacterised protein family UPF0047
EZH22_RS26570	COG2223	nitrite transmembrane transporter activity
EZH22_RS26585	COG0495	leucyl-tRNA aminoacylation
EZH22_RS26595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZH22_RS26600	COG0359	binds to the 23S rRNA
EZH22_RS26610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EZH22_RS26615	COG0360	Binds together with S18 to 16S ribosomal RNA
EZH22_RS26620	COG0726	polysaccharide deacetylase
EZH22_RS26625	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EZH22_RS26640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZH22_RS26645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EZH22_RS26655	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
EZH22_RS26670	COG0824	Thioesterase
EZH22_RS26695	COG0587	DNA-directed DNA polymerase activity
EZH22_RS26715	COG1489	DNA binding
EZH22_RS26730	COG0596	Alpha beta hydrolase
EZH22_RS26745	COG0590	tRNA wobble adenosine to inosine editing
EZH22_RS26750	COG1187	pseudouridine synthase activity
EZH22_RS26755	COG0742	ribosomal rna small subunit methyltransferase
EZH22_RS26760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EZH22_RS26765	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EZH22_RS26770	COG0459	protein refolding
EZH22_RS26785	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EZH22_RS26785	COG2066	Belongs to the glutaminase family
EZH22_RS26815	COG0181	hydroxymethylbilane synthase activity
EZH22_RS26820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EZH22_RS26825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EZH22_RS26845	COG2264	protein methyltransferase activity
EZH22_RS26860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_RS26865	COG3706	GGDEF domain
EZH22_RS26870	COG2264	protein methyltransferase activity
EZH22_RS26885	COG0277	FAD linked oxidase domain protein
EZH22_RS26920	COG4974	Belongs to the 'phage' integrase family
EZH22_RS26930	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EZH22_RS26935	COG1595	DNA-templated transcription, initiation
EZH22_RS26950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EZH22_RS26965	COG3707	response regulator
EZH22_RS26970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_RS26975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_RS26980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS26985	COG1116	anion transmembrane transporter activity
EZH22_RS26995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EZH22_RS27005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EZH22_RS27010	COG0243	molybdopterin cofactor binding
EZH22_RS27015	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EZH22_RS27020	COG0456	acetyltransferase
EZH22_RS27030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZH22_RS27050	COG0438	transferase activity, transferring glycosyl groups
EZH22_RS27060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_RS27065	COG0025	NhaP-type Na H and K H
EZH22_RS27070	COG4566	intracellular signal transduction
EZH22_RS27075	COG0783	Belongs to the Dps family
EZH22_RS27085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EZH22_RS27085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EZH22_RS27110	COG0243	molybdopterin cofactor binding
EZH22_RS27115	COG1271	oxidase subunit
EZH22_RS27130	COG4191	Histidine kinase
EZH22_RS27140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZH22_RS27145	COG0251	oxidation-reduction process
EZH22_RS27170	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS27190	COG2188	Transcriptional regulator
EZH22_RS27215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS27220	COG1116	anion transmembrane transporter activity
EZH22_RS27225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZH22_RS27230	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS27240	COG1335	isochorismatase
EZH22_RS27270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_RS27285	COG0163	prenyltransferase activity
EZH22_RS27295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EZH22_RS27305	COG1040	competence protein
EZH22_RS27315	COG1937	Protein conserved in bacteria
EZH22_RS27320	COG0180	Tryptophanyl-tRNA synthetase
EZH22_RS27325	COG0728	peptidoglycan biosynthetic process
EZH22_RS27330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EZH22_RS27345	COG0302	gtp cyclohydrolase
EZH22_RS27350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EZH22_RS27355	COG1752	Esterase of the alpha-beta hydrolase superfamily
EZH22_RS27360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_RS27375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EZH22_RS27380	COG1324	tolerance protein
EZH22_RS27390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_RS27395	COG1376	ErfK ybiS ycfS ynhG family protein
EZH22_RS27400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EZH22_RS27405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EZH22_RS27420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EZH22_RS27425	COG0305	Participates in initiation and elongation during chromosome replication
EZH22_RS27455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZH22_RS27465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EZH22_RS27475	COG2005	Transcriptional regulator
EZH22_RS27480	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EZH22_RS27485	COG4133	protoheme IX ABC transporter activity
EZH22_RS27490	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EZH22_RS27505	COG0640	Transcriptional regulator
EZH22_RS27535	COG0604	alcohol dehydrogenase
EZH22_RS27540	COG2186	Transcriptional regulator
EZH22_RS27555	COG1024	Enoyl-CoA hydratase
EZH22_RS27560	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS27565	COG3706	GGDEF domain
EZH22_RS27575	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EZH22_RS27585	COG1007	ATP synthesis coupled electron transport
EZH22_RS27620	COG0583	DNA-binding transcription factor activity
EZH22_RS27635	COG0402	S-adenosylhomocysteine deaminase activity
EZH22_RS27645	COG3485	protocatechuate 3,4-dioxygenase
EZH22_RS27650	COG0277	FAD linked oxidase domain protein
EZH22_RS27655	COG1129	ABC transporter
EZH22_RS27660	COG1172	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS27665	COG1172	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS27720	COG0714	Associated with various cellular activities
EZH22_RS27740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_RS27745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_RS27750	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS27755	COG1902	pentaerythritol trinitrate reductase activity
EZH22_RS27760	COG1764	response to oxidative stress
EZH22_RS27770	COG1522	sequence-specific DNA binding
EZH22_RS27795	COG2205	protein histidine kinase activity
EZH22_RS27805	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EZH22_RS27820	COG2132	Multicopper oxidase
EZH22_RS27845	COG2963	transposase activity
EZH22_RS27850	COG3436	PFAM IS66 Orf2 family protein
EZH22_RS27870	COG1396	sequence-specific DNA binding
EZH22_RS27875	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
EZH22_RS27880	COG2963	transposase activity
EZH22_RS27885	COG3436	PFAM IS66 Orf2 family protein
EZH22_RS27890	COG4372	Transposase
EZH22_RS27905	COG3436	PFAM IS66 Orf2 family protein
EZH22_RS27910	COG2963	transposase activity
EZH22_RS27945	COG2084	Dehydrogenase
EZH22_RS27960	COG0583	DNA-binding transcription factor activity
EZH22_RS27970	COG1024	Enoyl-CoA hydratase
EZH22_RS27970	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_RS27975	COG1053	succinate dehydrogenase
EZH22_RS27980	COG0183	Belongs to the thiolase family
EZH22_RS28015	COG2814	Major facilitator Superfamily
EZH22_RS28020	COG1566	PFAM secretion protein HlyD family protein
EZH22_RS28030	COG1289	transmembrane transporter activity
EZH22_RS28060	COG5433	transposase activity
EZH22_RS28065	COG5433	transposase activity
EZH22_RS28070	COG1414	Transcriptional regulator
EZH22_RS28075	COG1024	Enoyl-CoA hydratase
EZH22_RS28080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZH22_RS28080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZH22_RS28230	COG4974	Belongs to the 'phage' integrase family
EZH22_RS28235	COG0582	viral genome integration into host DNA
EZH22_RS28240	COG4974	Belongs to the 'phage' integrase family
EZH22_RS28300	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
EZH22_RS28335	COG0640	Transcriptional regulator
EZH22_RS28355	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
EZH22_RS28365	COG1414	Transcriptional regulator
EZH22_RS28370	COG1475	DNA binding
EZH22_RS28375	COG1192	Involved in chromosome partitioning
EZH22_RS28400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZH22_RS28415	COG3838	Conjugal transfer protein Trbc
EZH22_RS28420	COG3702	type iv secretory pathway
EZH22_RS28425	COG3451	type IV secretory pathway VirB4
EZH22_RS28440	COG3704	protein secretion by the type IV secretion system
EZH22_RS28445	COG3736	Type IV secretory pathway, component VirB8
EZH22_RS28450	COG3504	Conjugal transfer protein
EZH22_RS28455	COG2948	multi-organism process
EZH22_RS28460	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
EZH22_RS28475	COG1484	DNA-dependent DNA replication
EZH22_RS28480	COG3335	DDE superfamily endonuclease
EZH22_RS28485	COG3415	Transposase
EZH22_RS28490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS28500	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS28510	COG1024	Enoyl-CoA hydratase
EZH22_RS28515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZH22_RS28520	COG1309	transcriptional regulator
EZH22_RS28545	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS28550	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS28560	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS28565	COG2030	dehydratase
EZH22_RS28575	COG0183	Belongs to the thiolase family
EZH22_RS28600	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS28605	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS28610	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS28615	COG1024	Enoyl-CoA hydratase
EZH22_RS28630	COG2963	transposase activity
EZH22_RS28635	COG3436	PFAM IS66 Orf2 family protein
EZH22_RS28640	COG4372	Transposase
EZH22_RS28645	COG1309	transcriptional regulator
EZH22_RS28650	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS28655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_RS28685	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS28700	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EZH22_RS28705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZH22_RS28720	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS28725	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS28740	COG3436	PFAM IS66 Orf2 family protein
EZH22_RS28750	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZH22_RS28755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZH22_RS28775	COG1022	Amp-dependent synthetase and ligase
EZH22_RS28785	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS28835	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EZH22_RS28840	COG2086	electron transfer activity
EZH22_RS28850	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
EZH22_RS28880	COG3415	Transposase
EZH22_RS28885	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS28895	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS28900	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS28905	COG2030	dehydratase
EZH22_RS28915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS28920	COG2086	electron transfer activity
EZH22_RS28925	COG1024	Enoyl-CoA hydratase
EZH22_RS28930	COG1024	Enoyl-CoA hydratase
EZH22_RS28955	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_RS28960	COG1022	Amp-dependent synthetase and ligase
EZH22_RS28975	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS28995	COG2030	dehydratase
EZH22_RS29010	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EZH22_RS29010	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZH22_RS29020	COG1960	acyl-CoA dehydrogenase activity
EZH22_RS29025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS29030	COG2188	Transcriptional regulator
EZH22_RS29040	COG2301	Belongs to the HpcH HpaI aldolase family
EZH22_RS29045	COG2226	methyltransferase
EZH22_RS29060	COG3321	synthase
EZH22_RS29060	COG0604	alcohol dehydrogenase
EZH22_RS29060	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS29065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS29075	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS29085	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_RS29090	COG2030	dehydratase
EZH22_RS29115	COG1414	Transcriptional regulator
EZH22_RS29125	COG1137	ATPase activity
EZH22_RS29155	COG3505	Type IV secretory pathway VirD4
EZH22_RS29160	COG3077	Addiction module antitoxin, RelB DinJ family
EZH22_RS29195	COG3831	ATPase activity
EZH22_RS29205	COG2161	toxin-antitoxin pair type II binding
EZH22_RS29220	COG5489	Protein of unknown function (DUF736)
EZH22_RS29235	COG4227	nucleotidyltransferase activity
EZH22_RS29275	COG1475	DNA binding
EZH22_RS29305	COG5642	Protein of unknown function (DUF2384)
EZH22_RS29320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EZH22_RS29350	COG4974	Belongs to the 'phage' integrase family
EZH22_RS29380	COG2963	transposase activity
EZH22_RS29385	COG3436	PFAM IS66 Orf2 family protein
EZH22_RS29390	COG4372	Transposase
EZH22_RS29405	COG2205	protein histidine kinase activity
EZH22_RS29410	COG2814	Major facilitator Superfamily
EZH22_RS29415	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EZH22_RS29430	COG2132	Multicopper oxidase
EZH22_RS29470	COG3831	ATPase activity
EZH22_RS29480	COG5489	Protein of unknown function (DUF736)
EZH22_RS29600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZH22_RS29605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZH22_RS29615	COG2132	Multicopper oxidase
EZH22_RS29670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EZH22_RS29680	COG0247	lactate metabolic process
EZH22_RS29685	COG0277	FAD linked oxidase domain protein
EZH22_RS29690	COG0277	FAD linked oxidase domain protein
EZH22_RS29695	COG0625	glutathione transferase activity
EZH22_RS29700	COG0277	FAD linked oxidase domain protein
EZH22_RS29705	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_RS29710	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_RS29730	COG0395	ABC-type sugar transport system, permease component
EZH22_RS29735	COG1175	transmembrane transport
EZH22_RS29745	COG3842	ATPase activity
EZH22_RS29750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_RS29790	COG4644	lycopene metabolic process
EZH22_RS29830	COG1063	alcohol dehydrogenase
EZH22_RS29855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EZH22_RS29905	COG4644	lycopene metabolic process
EZH22_RS29935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EZH22_RS30015	COG0640	Transcriptional regulator
EZH22_RS30020	COG1475	DNA binding
EZH22_RS30025	COG1192	Involved in chromosome partitioning
EZH22_RS30030	COG3916	Acyl-homoserine-lactone synthase
EZH22_RS30035	COG4962	Type ii secretion system protein e
EZH22_RS30040	COG3838	Conjugal transfer protein Trbc
EZH22_RS30050	COG3451	type IV secretory pathway VirB4
EZH22_RS30055	COG5314	conjugation
EZH22_RS30065	COG3846	protein secretion by the type IV secretion system
EZH22_RS30070	COG3701	Conjugal transfer protein
EZH22_RS30100	COG0515	serine threonine protein kinase
EZH22_RS30100	COG2815	serine threonine protein kinase
EZH22_RS30105	COG2815	serine threonine protein kinase
EZH22_RS30105	COG0515	serine threonine protein kinase
EZH22_RS30140	COG4959	Type IV secretory pathway protease TraF
EZH22_RS30230	COG1396	sequence-specific DNA binding
EZH22_RS30270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EZH22_RS30310	COG0789	Transcriptional regulator
EZH22_RS30315	COG2217	Heavy metal translocating P-type atpase
EZH22_RS30315	COG2217	Heavy metal translocating P-type atpase
EZH22_RS30430	COG0582	viral genome integration into host DNA
EZH22_RS30435	COG2827	Endonuclease containing a URI domain
EZH22_RS30530	COG4957	zinc ion binding
EZH22_RS30540	COG4957	zinc ion binding
EZH22_RS30560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EZH22_RS30575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EZH22_RS30640	COG0210	DNA helicase
EZH22_RS30875	COG4957	zinc ion binding
EZH22_RS30900	COG4644	lycopene metabolic process
EZH22_RS30940	COG3047	cAMP biosynthetic process
EZH22_RS30950	COG1063	alcohol dehydrogenase
EZH22_RS30965	COG2871	sodium ion transport
EZH22_RS31010	COG0196	riboflavin kinase activity
EZH22_RS31030	COG0583	DNA-binding transcription factor activity
EZH22_RS31040	COG2135	peptidase activity
EZH22_RS31195	COG1074	ATP-dependent DNA helicase activity
EZH22_RS31260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EZH22_RS31355	COG1192	Involved in chromosome partitioning
EZH22_RS31365	COG3609	addiction module antidote protein, CC2985 family
EZH22_RS31375	COG3831	ATPase activity
EZH22_RS31380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EZH22_RS31455	COG1192	Involved in chromosome partitioning
EZH22_RS31465	COG3609	addiction module antidote protein, CC2985 family
EZH22_RS31475	COG3831	ATPase activity