locus-tag	class	description
C7S18_RS00075	COG3668	Plasmid stabilization system
C7S18_RS00090	COG3039	Transposase
C7S18_RS00140	COG1278	Cold shock
C7S18_RS00180	COG3483	tryptophan 2,3-dioxygenase activity
C7S18_RS00195	COG3220	belongs to the UPF0276 family
C7S18_RS00205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7S18_RS00210	COG2199	diguanylate cyclase activity
C7S18_RS00215	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C7S18_RS00220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7S18_RS00225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C7S18_RS00245	COG4245	von Willebrand factor, type A
C7S18_RS00250	COG0631	protein serine/threonine phosphatase activity
C7S18_RS00255	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
C7S18_RS00260	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
C7S18_RS00275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7S18_RS00280	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C7S18_RS00285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7S18_RS00305	COG2423	ornithine cyclodeaminase activity
C7S18_RS00345	COG0463	Glycosyl transferase, family 2
C7S18_RS00355	COG0753	catalase activity
C7S18_RS00360	COG5001	Diguanylate cyclase
C7S18_RS00360	COG4251	negative regulation of phosphorylation
C7S18_RS00360	COG2203	Gaf domain
C7S18_RS00360	COG3706	GGDEF domain
C7S18_RS00365	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C7S18_RS00370	COG2224	Isocitrate lyase
C7S18_RS00385	COG1862	Preprotein translocase
C7S18_RS00395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7S18_RS00410	COG0425	Belongs to the sulfur carrier protein TusA family
C7S18_RS00415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7S18_RS00420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C7S18_RS00440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C7S18_RS00450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7S18_RS00455	COG0175	sulfate reduction
C7S18_RS00460	COG0529	Catalyzes the synthesis of activated sulfate
C7S18_RS00460	COG2046	Belongs to the sulfate adenylyltransferase family
C7S18_RS00480	COG0463	Glycosyl transferase, family 2
C7S18_RS00485	COG2267	carboxylic ester hydrolase activity
C7S18_RS00505	COG2409	Drug exporters of the RND superfamily
C7S18_RS00530	COG1404	Belongs to the peptidase S8 family
C7S18_RS00535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7S18_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS00570	COG0288	reversible hydration of carbon dioxide
C7S18_RS00580	COG4122	O-methyltransferase activity
C7S18_RS00600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7S18_RS00600	COG0116	Belongs to the methyltransferase superfamily
C7S18_RS00640	COG0515	serine threonine protein kinase
C7S18_RS00700	COG2815	serine threonine protein kinase
C7S18_RS00700	COG0515	serine threonine protein kinase
C7S18_RS00715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C7S18_RS00730	COG0513	Belongs to the DEAD box helicase family
C7S18_RS00735	COG0823	Involved in the tonB-independent uptake of proteins
C7S18_RS00740	COG1794	racemase activity, acting on amino acids and derivatives
C7S18_RS00760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C7S18_RS00770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7S18_RS00780	COG3541	Predicted nucleotidyltransferase
C7S18_RS00800	COG2226	methyltransferase
C7S18_RS00805	COG2755	lipolytic protein G-D-S-L family
C7S18_RS00845	COG0457	Tetratricopeptide repeat
C7S18_RS00845	COG0515	serine threonine protein kinase
C7S18_RS00855	COG1940	carbohydrate kinase activity
C7S18_RS00865	COG3104	oligopeptide transport
C7S18_RS00870	COG0427	acetyl-CoA hydrolase
C7S18_RS00880	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C7S18_RS00885	COG3118	belongs to the thioredoxin family
C7S18_RS00905	COG5002	protein histidine kinase activity
C7S18_RS00905	COG0784	Response regulator, receiver
C7S18_RS00905	COG2205	protein histidine kinase activity
C7S18_RS00955	COG0725	ABC transporter, periplasmic molybdate-binding protein
C7S18_RS00960	COG4149	molybdate abc transporter
C7S18_RS01015	COG0534	Mate efflux family protein
C7S18_RS01020	COG0616	signal peptide processing
C7S18_RS01035	COG0674	pyruvate-flavodoxin oxidoreductase activity
C7S18_RS01035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C7S18_RS01070	COG3710	Transcriptional regulator
C7S18_RS01135	COG3291	Pkd domain containing protein
C7S18_RS01150	COG0640	Transcriptional regulator
C7S18_RS01160	COG1309	transcriptional regulator
C7S18_RS01175	COG2815	serine threonine protein kinase
C7S18_RS01175	COG0515	serine threonine protein kinase
C7S18_RS01190	COG2169	Transcriptional regulator
C7S18_RS01190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C7S18_RS01205	COG1051	belongs to the nudix hydrolase family
C7S18_RS01225	COG1981	membrane
C7S18_RS01235	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C7S18_RS01240	COG0138	bifunctional purine biosynthesis protein purh
C7S18_RS01250	COG1024	Enoyl-CoA hydratase
C7S18_RS01250	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7S18_RS01255	COG0183	Belongs to the thiolase family
C7S18_RS01260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7S18_RS01265	COG0339	signal peptide processing
C7S18_RS01275	COG0275	rRNA processing
C7S18_RS01280	COG3116	cell division
C7S18_RS01295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7S18_RS01300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7S18_RS01315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7S18_RS01320	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7S18_RS01340	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C7S18_RS01350	COG0739	heme binding
C7S18_RS01355	COG0653	protein targeting
C7S18_RS01360	COG0352	thiamine-phosphate diphosphorylase activity
C7S18_RS01415	COG0515	serine threonine protein kinase
C7S18_RS01415	COG0457	Tetratricopeptide repeat
C7S18_RS01435	COG0530	calcium, potassium:sodium antiporter activity
C7S18_RS01455	COG1404	Belongs to the peptidase S8 family
C7S18_RS01480	COG1187	pseudouridine synthase activity
C7S18_RS01495	COG1530	ribonuclease E activity
C7S18_RS01500	COG0564	pseudouridine synthase activity
C7S18_RS01530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C7S18_RS01535	COG0626	cystathionine gamma-synthase activity
C7S18_RS01540	COG1522	sequence-specific DNA binding
C7S18_RS01585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7S18_RS01610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7S18_RS01615	COG0604	alcohol dehydrogenase
C7S18_RS01655	COG1392	Phosphate transport regulator
C7S18_RS01660	COG0306	phosphate transporter
C7S18_RS01670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7S18_RS01700	COG1570	exodeoxyribonuclease VII activity
C7S18_RS01725	COG2207	Transcriptional regulator
C7S18_RS01730	COG4206	TonB-dependent receptor
C7S18_RS01775	COG2914	Belongs to the UPF0125 (RnfH) family
C7S18_RS01780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7S18_RS01810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7S18_RS01815	COG0497	DNA recombination
C7S18_RS01820	COG1596	polysaccharide export
C7S18_RS01820	COG1555	photosystem II stabilization
C7S18_RS01840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7S18_RS01840	COG0678	peroxiredoxin activity
C7S18_RS01845	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS01850	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7S18_RS01860	COG0405	Gamma-glutamyltransferase
C7S18_RS01865	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS01880	COG4242	Belongs to the peptidase S51 family
C7S18_RS01885	COG1760	l-serine dehydratase
C7S18_RS01900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7S18_RS01905	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7S18_RS01915	COG2086	electron transfer activity
C7S18_RS01930	COG3118	belongs to the thioredoxin family
C7S18_RS01960	COG0730	response to heat
C7S18_RS01995	COG0754	glutathionylspermidine amidase activity
C7S18_RS02000	COG0069	glutamate synthase activity
C7S18_RS02020	COG1960	acyl-CoA dehydrogenase activity
C7S18_RS02030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7S18_RS02040	COG1960	acyl-CoA dehydrogenase activity
C7S18_RS02060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7S18_RS02065	COG0575	Belongs to the CDS family
C7S18_RS02070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C7S18_RS02075	COG0750	zinc metalloprotease
C7S18_RS02080	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7S18_RS02090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7S18_RS02100	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7S18_RS02135	COG1278	Cold shock
C7S18_RS02145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7S18_RS02170	COG4977	sequence-specific DNA binding
C7S18_RS02175	COG3012	SEC-C Motif Domain Protein
C7S18_RS02235	COG0515	serine threonine protein kinase
C7S18_RS02235	COG2815	serine threonine protein kinase
C7S18_RS02245	COG0800	Aldolase
C7S18_RS02250	COG0837	glucose binding
C7S18_RS02265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C7S18_RS02330	COG0596	Alpha beta hydrolase
C7S18_RS02335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C7S18_RS02345	COG5265	(ABC) transporter
C7S18_RS02360	COG0717	Belongs to the dCTP deaminase family
C7S18_RS02365	COG0489	protein tyrosine kinase activity
C7S18_RS02375	COG4771	TonB-dependent receptor
C7S18_RS02380	COG0457	Tetratricopeptide repeat
C7S18_RS02385	COG5001	Diguanylate cyclase
C7S18_RS02385	COG3300	MHYT domain
C7S18_RS02400	COG1446	asparaginase
C7S18_RS02420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7S18_RS02425	COG0305	Participates in initiation and elongation during chromosome replication
C7S18_RS02450	COG3046	protein related to deoxyribodipyrimidine photolyase
C7S18_RS02455	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS02475	COG1136	(ABC) transporter
C7S18_RS02480	COG4591	ABC-type transport system involved in lipoprotein release permease component
C7S18_RS02485	COG2986	histidine ammonia-lyase
C7S18_RS02525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7S18_RS02530	COG4650	regulator
C7S18_RS02540	COG1690	Belongs to the RtcB family
C7S18_RS02555	COG0384	phenazine biosynthesis protein PhzF
C7S18_RS02575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7S18_RS02585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7S18_RS02590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C7S18_RS02650	COG0181	hydroxymethylbilane synthase activity
C7S18_RS02655	COG3158	transport of potassium into the cell
C7S18_RS02660	COG2255	four-way junction helicase activity
C7S18_RS02700	COG1966	Carbon starvation protein
C7S18_RS02710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7S18_RS02715	COG1611	Belongs to the LOG family
C7S18_RS02720	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C7S18_RS02730	COG1902	pentaerythritol trinitrate reductase activity
C7S18_RS02730	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7S18_RS02750	COG0384	phenazine biosynthesis protein PhzF
C7S18_RS02760	COG0336	Belongs to the RNA methyltransferase TrmD family
C7S18_RS02770	COG0228	four-way junction DNA binding
C7S18_RS02775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C7S18_RS02780	COG4137	Cytochrome C assembly protein
C7S18_RS02795	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C7S18_RS02825	COG0492	ferredoxin-NADP+ reductase activity
C7S18_RS02830	COG1674	ftsk spoiiie
C7S18_RS02835	COG1024	Enoyl-CoA hydratase
C7S18_RS02855	COG0515	serine threonine protein kinase
C7S18_RS02890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7S18_RS02920	COG5001	Diguanylate cyclase
C7S18_RS02950	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C7S18_RS03010	COG0210	DNA helicase
C7S18_RS03015	COG1228	amidohydrolase
C7S18_RS03025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7S18_RS03030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S18_RS03045	COG1309	transcriptional regulator
C7S18_RS03055	COG3100	YcgL domain-containing protein
C7S18_RS03070	COG0018	arginyl-trna synthetase
C7S18_RS03075	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C7S18_RS03080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7S18_RS03120	COG1388	LysM domain
C7S18_RS03120	COG0741	lytic transglycosylase activity
C7S18_RS03125	COG0456	acetyltransferase
C7S18_RS03210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C7S18_RS03215	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C7S18_RS03245	COG4266	Belongs to the allantoicase family
C7S18_RS03250	COG1137	ATPase activity
C7S18_RS03265	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C7S18_RS03275	COG0271	Belongs to the BolA IbaG family
C7S18_RS03280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7S18_RS03295	COG0789	Transcriptional regulator
C7S18_RS03320	COG0402	S-adenosylhomocysteine deaminase activity
C7S18_RS03370	COG0493	'glutamate synthase
C7S18_RS03390	COG1953	Uracil, thiamine, allantoin
C7S18_RS03405	COG0784	Response regulator, receiver
C7S18_RS03405	COG2198	Histidine kinase
C7S18_RS03405	COG5002	protein histidine kinase activity
C7S18_RS03430	COG2304	oxidoreductase activity
C7S18_RS03435	COG4152	abc transporter atp-binding protein
C7S18_RS03440	COG1668	transmembrane transport
C7S18_RS03455	COG0552	protein localization to endoplasmic reticulum
C7S18_RS03460	COG0742	ribosomal rna small subunit methyltransferase
C7S18_RS03465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7S18_RS03475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7S18_RS03485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C7S18_RS03535	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C7S18_RS03550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C7S18_RS03555	COG3706	GGDEF domain
C7S18_RS03565	COG2194	sulfuric ester hydrolase activity
C7S18_RS03575	COG2197	response regulator
C7S18_RS03600	COG0328	RNA-DNA hybrid ribonuclease activity
C7S18_RS03610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7S18_RS03655	COG0519	Catalyzes the synthesis of GMP from XMP
C7S18_RS03655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7S18_RS03680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C7S18_RS03685	COG1127	ABC transporter
C7S18_RS03700	COG1846	Transcriptional regulator
C7S18_RS03700	COG0456	acetyltransferase
C7S18_RS03720	COG1322	Protein conserved in bacteria
C7S18_RS03725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7S18_RS03775	COG2239	Acts as a magnesium transporter
C7S18_RS03845	COG0823	Involved in the tonB-independent uptake of proteins
C7S18_RS03845	COG1506	peptidase
C7S18_RS03850	COG0762	integral membrane protein
C7S18_RS03860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C7S18_RS03875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7S18_RS03890	COG0538	isocitrate dehydrogenase activity
C7S18_RS03895	COG1183	phosphatidylcholine synthase activity
C7S18_RS03915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C7S18_RS03920	COG1127	ABC transporter
C7S18_RS03935	COG5001	Diguanylate cyclase
C7S18_RS03935	COG5002	protein histidine kinase activity
C7S18_RS03950	COG0456	acetyltransferase
C7S18_RS03965	COG4566	intracellular signal transduction
C7S18_RS03990	COG1136	(ABC) transporter
C7S18_RS04000	COG3275	phosphorelay sensor kinase activity
C7S18_RS04005	COG3279	Response regulator of the LytR AlgR family
C7S18_RS04010	COG0583	DNA-binding transcription factor activity
C7S18_RS04085	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C7S18_RS04100	COG0793	Belongs to the peptidase S41A family
C7S18_RS04100	COG4946	Tricorn protease homolog
C7S18_RS04110	COG2356	endonuclease I
C7S18_RS04135	COG0542	response to heat
C7S18_RS04160	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C7S18_RS04170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7S18_RS04205	COG0358	DNA primase activity
C7S18_RS04220	COG0582	viral genome integration into host DNA
C7S18_RS04235	COG3273	potassium ion transport
C7S18_RS04235	COG0471	metal ion transport
C7S18_RS04250	COG4206	TonB-dependent receptor
C7S18_RS04255	COG2226	methyltransferase
C7S18_RS04270	COG1012	belongs to the aldehyde dehydrogenase family
C7S18_RS04275	COG1177	transmembrane transport
C7S18_RS04280	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7S18_RS04285	COG3842	ATPase activity
C7S18_RS04305	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7S18_RS04310	COG0174	glutamine synthetase
C7S18_RS04315	COG0494	nUDIX hydrolase
C7S18_RS04320	COG1218	3'(2'),5'-bisphosphate nucleotidase
C7S18_RS04325	COG3956	TIGRFAM MazG family protein
C7S18_RS04330	COG0515	serine threonine protein kinase
C7S18_RS04330	COG2815	serine threonine protein kinase
C7S18_RS04340	COG0515	serine threonine protein kinase
C7S18_RS04340	COG2815	serine threonine protein kinase
C7S18_RS04345	COG2815	serine threonine protein kinase
C7S18_RS04345	COG0515	serine threonine protein kinase
C7S18_RS04355	COG0515	serine threonine protein kinase
C7S18_RS04380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C7S18_RS04380	COG0426	domain, Protein
C7S18_RS04400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7S18_RS04400	COG1703	isobutyryl-CoA mutase activity
C7S18_RS04400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7S18_RS04435	COG0494	nUDIX hydrolase
C7S18_RS04465	COG3039	Transposase
C7S18_RS04520	COG3039	Transposase
C7S18_RS04615	COG2815	serine threonine protein kinase
C7S18_RS04615	COG0515	serine threonine protein kinase
C7S18_RS04625	COG1404	Belongs to the peptidase S8 family
C7S18_RS04665	COG0243	molybdopterin cofactor binding
C7S18_RS04725	COG0515	serine threonine protein kinase
C7S18_RS04725	COG2815	serine threonine protein kinase
C7S18_RS04760	COG0515	serine threonine protein kinase
C7S18_RS04760	COG2815	serine threonine protein kinase
C7S18_RS04810	COG0735	belongs to the Fur family
C7S18_RS04830	COG3852	Histidine kinase
C7S18_RS04890	COG0515	serine threonine protein kinase
C7S18_RS04890	COG2815	serine threonine protein kinase
C7S18_RS04900	COG2815	serine threonine protein kinase
C7S18_RS04900	COG0515	serine threonine protein kinase
C7S18_RS04915	COG0626	cystathionine gamma-synthase activity
C7S18_RS04930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C7S18_RS04950	COG1199	ATP-dependent helicase activity
C7S18_RS04960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7S18_RS04965	COG1506	peptidase
C7S18_RS04965	COG0823	Involved in the tonB-independent uptake of proteins
C7S18_RS04975	COG2350	Protein conserved in bacteria
C7S18_RS04985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C7S18_RS04990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C7S18_RS04995	COG1187	pseudouridine synthase activity
C7S18_RS05000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C7S18_RS05005	COG2967	ApaG domain
C7S18_RS05020	COG1611	Belongs to the LOG family
C7S18_RS05025	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C7S18_RS05035	COG1994	Peptidase M50
C7S18_RS05055	COG0515	serine threonine protein kinase
C7S18_RS05055	COG2815	serine threonine protein kinase
C7S18_RS05080	COG0348	domain, Protein
C7S18_RS05105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C7S18_RS05115	COG0527	aspartate kinase activity
C7S18_RS05115	COG0460	homoserine dehydrogenase
C7S18_RS05120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7S18_RS05130	COG0776	regulation of translation
C7S18_RS05140	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C7S18_RS05160	COG1228	amidohydrolase
C7S18_RS05210	COG0386	Belongs to the glutathione peroxidase family
C7S18_RS05215	COG0295	cytidine deaminase activity
C7S18_RS05220	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7S18_RS05225	COG1404	Belongs to the peptidase S8 family
C7S18_RS05225	COG4412	M6 family metalloprotease domain protein
C7S18_RS05240	COG2133	pyrroloquinoline quinone binding
C7S18_RS05255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7S18_RS05260	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C7S18_RS05315	COG0483	inositol monophosphate 1-phosphatase activity
C7S18_RS05325	COG1505	serine-type exopeptidase activity
C7S18_RS05330	COG0741	lytic transglycosylase activity
C7S18_RS05360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C7S18_RS05365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7S18_RS05370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7S18_RS05375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C7S18_RS05380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7S18_RS05385	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C7S18_RS05430	COG4206	TonB-dependent receptor
C7S18_RS05510	COG2828	Protein conserved in bacteria
C7S18_RS05540	COG0811	peptide transport
C7S18_RS05545	COG0848	biopolymer transport protein
C7S18_RS05555	COG1663	tetraacyldisaccharide 4'-kinase activity
C7S18_RS05565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7S18_RS05575	COG0322	excinuclease ABC activity
C7S18_RS05600	COG0582	viral genome integration into host DNA
C7S18_RS05645	COG1956	GAF domain-containing protein
C7S18_RS05660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7S18_RS05670	COG1686	Belongs to the peptidase S11 family
C7S18_RS05680	COG2951	lytic endotransglycosylase activity
C7S18_RS05685	COG0697	spore germination
C7S18_RS05695	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C7S18_RS05705	COG3647	Membrane
C7S18_RS05745	COG0582	viral genome integration into host DNA
C7S18_RS05760	COG0515	serine threonine protein kinase
C7S18_RS05765	COG0142	geranyltranstransferase activity
C7S18_RS05775	COG0629	single-stranded DNA binding
C7S18_RS05820	COG1228	amidohydrolase
C7S18_RS05830	COG3118	belongs to the thioredoxin family
C7S18_RS05860	COG1399	metal-binding, possibly nucleic acid-binding protein
C7S18_RS05865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7S18_RS05870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7S18_RS05880	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS05900	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C7S18_RS05905	COG4181	ATPase activity
C7S18_RS05925	COG1834	amidinotransferase
C7S18_RS05960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C7S18_RS05965	COG0137	argininosuccinate synthase activity
C7S18_RS05970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7S18_RS05975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7S18_RS05980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C7S18_RS05985	COG0165	Argininosuccinate lyase
C7S18_RS05990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7S18_RS06030	COG3039	Transposase
C7S18_RS06355	COG3039	Transposase
C7S18_RS06365	COG2319	Wd-40 repeat
C7S18_RS06365	COG4249	Peptidase C14 caspase catalytic subunit p20
C7S18_RS06460	COG3243	poly(R)-hydroxyalkanoic acid synthase
C7S18_RS06465	COG0076	glutamate decarboxylase activity
C7S18_RS06480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C7S18_RS06490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7S18_RS06500	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C7S18_RS06515	COG0617	tRNA 3'-terminal CCA addition
C7S18_RS06520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C7S18_RS06525	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C7S18_RS06530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C7S18_RS06535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7S18_RS06540	COG0167	dihydroorotate dehydrogenase activity
C7S18_RS06550	COG1012	belongs to the aldehyde dehydrogenase family
C7S18_RS06555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C7S18_RS06570	COG0433	COG0433 Predicted ATPase
C7S18_RS06575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7S18_RS06590	COG0577	efflux transmembrane transporter activity
C7S18_RS06590	COG1136	(ABC) transporter
C7S18_RS06600	COG1960	acyl-CoA dehydrogenase activity
C7S18_RS06620	COG1012	belongs to the aldehyde dehydrogenase family
C7S18_RS06625	COG3284	Transcriptional regulator
C7S18_RS06680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C7S18_RS06685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7S18_RS06690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7S18_RS06695	COG0066	3-isopropylmalate dehydratase activity
C7S18_RS06715	COG0134	indole-3-glycerol-phosphate synthase activity
C7S18_RS06725	COG1294	oxidase, subunit
C7S18_RS06730	COG1271	oxidase subunit
C7S18_RS06750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C7S18_RS06755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7S18_RS06760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C7S18_RS06760	COG0131	Imidazoleglycerol-phosphate dehydratase
C7S18_RS06770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C7S18_RS06780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C7S18_RS06780	COG0140	phosphoribosyl-ATP diphosphatase activity
C7S18_RS06785	COG1506	peptidase
C7S18_RS06785	COG0823	Involved in the tonB-independent uptake of proteins
C7S18_RS06810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7S18_RS06815	COG1217	gtp-binding protein TYPA
C7S18_RS06825	COG0285	dihydrofolate synthase activity
C7S18_RS06830	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C7S18_RS06835	COG0159	tryptophan synthase activity
C7S18_RS06840	COG0133	tryptophan synthase activity
C7S18_RS06845	COG0418	dihydroorotase activity
C7S18_RS06870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C7S18_RS06885	COG1132	(ABC) transporter
C7S18_RS06905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7S18_RS06910	COG1238	metal cluster binding
C7S18_RS06915	COG1388	LysM domain
C7S18_RS06915	COG4942	peptidase
C7S18_RS06930	COG1131	(ABC) transporter
C7S18_RS06940	COG3161	chorismate lyase activity
C7S18_RS06960	COG4221	oxidoreductase activity
C7S18_RS06970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7S18_RS06985	COG1012	belongs to the aldehyde dehydrogenase family
C7S18_RS07000	COG0515	serine threonine protein kinase
C7S18_RS07000	COG2815	serine threonine protein kinase
C7S18_RS07010	COG0515	serine threonine protein kinase
C7S18_RS07010	COG2815	serine threonine protein kinase
C7S18_RS07015	COG1595	DNA-templated transcription, initiation
C7S18_RS07035	COG0534	Mate efflux family protein
C7S18_RS07040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7S18_RS07045	COG4232	protein-disulfide reductase activity
C7S18_RS07060	COG2373	Large extracellular alpha-helical protein
C7S18_RS07065	COG4953	penicillin-binding protein 1C
C7S18_RS07075	COG0596	Alpha beta hydrolase
C7S18_RS07080	COG0642	Histidine kinase
C7S18_RS07100	COG0488	(ABC) transporter
C7S18_RS07105	COG3706	GGDEF domain
C7S18_RS07135	COG4589	Belongs to the CDS family
C7S18_RS07150	COG2453	phosphatase
C7S18_RS07150	COG0671	phosphoesterase, PA-phosphatase related
C7S18_RS07155	COG2267	carboxylic ester hydrolase activity
C7S18_RS07160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C7S18_RS07170	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C7S18_RS07200	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C7S18_RS07215	COG0415	Belongs to the DNA photolyase family
C7S18_RS07230	COG2119	membrane
C7S18_RS07240	COG1902	pentaerythritol trinitrate reductase activity
C7S18_RS07240	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7S18_RS07255	COG1505	serine-type exopeptidase activity
C7S18_RS07260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7S18_RS07270	COG4774	siderophore transport
C7S18_RS07280	COG3128	pkhd-type hydroxylase
C7S18_RS07290	COG0531	amino acid
C7S18_RS07305	COG0354	folic acid binding
C7S18_RS07315	COG2009	succinate dehydrogenase
C7S18_RS07320	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C7S18_RS07325	COG1053	succinate dehydrogenase
C7S18_RS07365	COG2819	hydrolase of the alpha beta superfamily
C7S18_RS07370	COG1192	Involved in chromosome partitioning
C7S18_RS07375	COG1475	DNA binding
C7S18_RS07385	COG0189	ligase activity
C7S18_RS07385	COG4067	protein conserved in archaea
C7S18_RS07400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C7S18_RS07405	COG0443	Heat shock 70 kDa protein
C7S18_RS07420	COG0456	acetyltransferase
C7S18_RS07420	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C7S18_RS07435	COG0583	DNA-binding transcription factor activity
C7S18_RS07450	COG0243	molybdopterin cofactor binding
C7S18_RS07465	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C7S18_RS07470	COG2850	peptidyl-arginine hydroxylation
C7S18_RS07505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C7S18_RS07525	COG0004	ammonium transporteR
C7S18_RS07540	COG2354	Protein conserved in bacteria
C7S18_RS07550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7S18_RS07565	COG1592	Rubrerythrin
C7S18_RS07575	COG1585	Membrane protein implicated in regulation of membrane protease activity
C7S18_RS07580	COG0330	HflC and HflK could
C7S18_RS07605	COG1560	Kdo2-lipid A biosynthetic process
C7S18_RS07610	COG1519	Transferase
C7S18_RS07650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7S18_RS07655	COG1138	Cytochrome C-type biogenesis protein
C7S18_RS07685	COG1404	Belongs to the peptidase S8 family
C7S18_RS07690	COG0527	aspartate kinase activity
C7S18_RS07700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7S18_RS07705	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C7S18_RS07715	COG1047	Peptidyl-prolyl cis-trans
C7S18_RS07730	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C7S18_RS07735	COG0312	modulator of DNA gyrase
C7S18_RS07780	COG0745	RESPONSE REGULATOR receiver
C7S18_RS07785	COG0642	Histidine kinase
C7S18_RS07810	COG0156	8-amino-7-oxononanoate synthase activity
C7S18_RS07815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C7S18_RS07835	COG0084	hydrolase, TatD family'
C7S18_RS07850	COG0584	glycerophosphoryl diester phosphodiesterase
C7S18_RS07855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C7S18_RS07885	COG4771	TonB-dependent receptor
C7S18_RS07925	COG2197	response regulator
C7S18_RS07935	COG3039	Transposase
C7S18_RS07945	COG1131	(ABC) transporter
C7S18_RS07975	COG1136	(ABC) transporter
C7S18_RS08005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7S18_RS08020	COG2124	cytochrome p450
C7S18_RS08025	COG0318	PFAM AMP-dependent synthetase and ligase
C7S18_RS08045	COG1131	(ABC) transporter
C7S18_RS08060	COG1136	(ABC) transporter
C7S18_RS08070	COG0577	efflux transmembrane transporter activity
C7S18_RS08090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C7S18_RS08120	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C7S18_RS08150	COG0640	Transcriptional regulator
C7S18_RS08155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7S18_RS08170	COG1404	Belongs to the peptidase S8 family
C7S18_RS08205	COG3264	Mechanosensitive ion channel
C7S18_RS08205	COG1511	domain protein
C7S18_RS08210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S18_RS08215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7S18_RS08260	COG3275	phosphorelay sensor kinase activity
C7S18_RS08265	COG3279	Response regulator of the LytR AlgR family
C7S18_RS08295	COG0642	Histidine kinase
C7S18_RS08310	COG1196	nuclear chromosome segregation
C7S18_RS08380	COG5002	protein histidine kinase activity
C7S18_RS08470	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS08495	COG4772	TonB-dependent receptor
C7S18_RS08525	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S18_RS08585	COG0672	)-iron permease
C7S18_RS08740	COG1022	Amp-dependent synthetase and ligase
C7S18_RS08750	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS08760	COG3279	Response regulator of the LytR AlgR family
C7S18_RS08765	COG3275	phosphorelay sensor kinase activity
C7S18_RS08785	COG3220	belongs to the UPF0276 family
C7S18_RS08810	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C7S18_RS08830	COG0753	catalase activity
C7S18_RS08845	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C7S18_RS08855	COG1063	alcohol dehydrogenase
C7S18_RS08870	COG0745	RESPONSE REGULATOR receiver
C7S18_RS08875	COG2205	protein histidine kinase activity
C7S18_RS08905	COG1051	belongs to the nudix hydrolase family
C7S18_RS08905	COG1056	cytidyltransferase-related domain
C7S18_RS08910	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C7S18_RS08940	COG1007	ATP synthesis coupled electron transport
C7S18_RS08955	COG0713	ATP synthesis coupled electron transport
C7S18_RS08965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S18_RS08970	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C7S18_RS08980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C7S18_RS08985	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C7S18_RS08990	COG0649	NAD binding
C7S18_RS08995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S18_RS09000	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S18_RS09005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S18_RS09015	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7S18_RS09020	COG0149	triose-phosphate isomerase activity
C7S18_RS09025	COG0300	oxidoreductase activity
C7S18_RS09035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7S18_RS09055	COG1012	belongs to the aldehyde dehydrogenase family
C7S18_RS09060	COG1396	sequence-specific DNA binding
C7S18_RS09060	COG1917	Cupin 2, conserved barrel domain protein
C7S18_RS09065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C7S18_RS09070	COG0686	Belongs to the AlaDH PNT family
C7S18_RS09075	COG0010	Belongs to the arginase family
C7S18_RS09100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C7S18_RS09105	COG0861	Integral membrane protein TerC family
C7S18_RS09120	COG0316	Belongs to the HesB IscA family
C7S18_RS09120	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C7S18_RS09125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7S18_RS09135	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C7S18_RS09155	COG4535	Mg2 and Co2 transporter CorC
C7S18_RS09160	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7S18_RS09170	COG1702	phosphate starvation-inducible protein PhoH
C7S18_RS09180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7S18_RS09190	COG0583	DNA-binding transcription factor activity
C7S18_RS09205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7S18_RS09210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S18_RS09215	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C7S18_RS09225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S18_RS09255	COG2813	Specifically methylates the guanine in position
C7S18_RS09270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7S18_RS09275	COG0557	exoribonuclease II activity
C7S18_RS09285	COG0515	serine threonine protein kinase
C7S18_RS09285	COG2815	serine threonine protein kinase
C7S18_RS09290	COG1546	Belongs to the CinA family
C7S18_RS09295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C7S18_RS09310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C7S18_RS09320	COG2197	response regulator
C7S18_RS09325	COG4585	Histidine kinase
C7S18_RS09330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7S18_RS09340	COG0515	serine threonine protein kinase
C7S18_RS09340	COG2815	serine threonine protein kinase
C7S18_RS09355	COG0746	molybdenum cofactor guanylyltransferase activity
C7S18_RS09360	COG0303	'Molybdopterin
C7S18_RS09365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C7S18_RS09470	COG2433	Pfam Transposase IS66
C7S18_RS09550	COG0585	pseudouridine synthase activity
C7S18_RS09660	COG1309	transcriptional regulator
C7S18_RS09675	COG0640	Transcriptional regulator
C7S18_RS09700	COG2272	Belongs to the type-B carboxylesterase lipase family
C7S18_RS09820	COG3739	integral membrane protein
C7S18_RS09850	COG0784	Response regulator, receiver
C7S18_RS09850	COG2198	Histidine kinase
C7S18_RS09850	COG5002	protein histidine kinase activity
C7S18_RS09875	COG3360	Dodecin
C7S18_RS09885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7S18_RS09890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C7S18_RS09905	COG0438	transferase activity, transferring glycosyl groups
C7S18_RS09905	COG1216	Glycosyl transferase, family 2
C7S18_RS09935	COG1054	Belongs to the UPF0176 family
C7S18_RS09950	COG4585	Histidine kinase
C7S18_RS09955	COG2197	response regulator
C7S18_RS09965	COG4206	TonB-dependent receptor
C7S18_RS09970	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7S18_RS09975	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C7S18_RS09980	COG0505	Belongs to the CarA family
C7S18_RS10000	COG1012	belongs to the aldehyde dehydrogenase family
C7S18_RS10010	COG0531	amino acid
C7S18_RS10025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7S18_RS10030	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C7S18_RS10035	COG0504	CTP synthase activity
C7S18_RS10040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7S18_RS10045	COG1393	Belongs to the ArsC family
C7S18_RS10050	COG2171	N-acyltransferase activity
C7S18_RS10070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7S18_RS10090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C7S18_RS10100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7S18_RS10110	COG0193	aminoacyl-tRNA hydrolase activity
C7S18_RS10115	COG0012	GTP binding
C7S18_RS10130	COG3039	Transposase
C7S18_RS10140	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C7S18_RS10215	COG3039	Transposase
C7S18_RS10325	COG3039	Transposase
C7S18_RS10370	COG1404	Belongs to the peptidase S8 family
C7S18_RS10385	COG0457	Tetratricopeptide repeat
C7S18_RS10405	COG1901	pseudouridine methyltransferase
C7S18_RS10450	COG0577	efflux transmembrane transporter activity
C7S18_RS10455	COG1136	(ABC) transporter
C7S18_RS10460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7S18_RS10535	COG0753	catalase activity
C7S18_RS10580	COG0671	phosphoesterase, PA-phosphatase related
C7S18_RS10585	COG0438	transferase activity, transferring glycosyl groups
C7S18_RS10595	COG0659	secondary active sulfate transmembrane transporter activity
C7S18_RS10620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C7S18_RS10630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C7S18_RS10635	COG0195	Participates in both transcription termination and antitermination
C7S18_RS10635	COG2251	uridine kinase activity
C7S18_RS10640	COG0779	Required for maturation of 30S ribosomal subunits
C7S18_RS10665	COG0039	L-malate dehydrogenase activity
C7S18_RS10705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C7S18_RS10715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C7S18_RS10720	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C7S18_RS10725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7S18_RS10730	COG2207	Transcriptional regulator
C7S18_RS10730	COG1917	Cupin 2, conserved barrel domain protein
C7S18_RS10745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S18_RS10760	COG0542	response to heat
C7S18_RS10765	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C7S18_RS10780	COG2915	High frequency lysogenization protein hflD homolog
C7S18_RS10790	COG0180	Tryptophanyl-tRNA synthetase
C7S18_RS10805	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7S18_RS10830	COG0745	RESPONSE REGULATOR receiver
C7S18_RS10835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7S18_RS10850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7S18_RS10870	COG2878	Part of a membrane complex involved in electron transport
C7S18_RS10875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7S18_RS10875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7S18_RS10880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7S18_RS10885	COG0802	atpase or kinase
C7S18_RS10890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C7S18_RS10890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C7S18_RS10905	COG2199	diguanylate cyclase activity
C7S18_RS10915	COG0515	serine threonine protein kinase
C7S18_RS10915	COG2815	serine threonine protein kinase
C7S18_RS10955	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C7S18_RS10965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7S18_RS10985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C7S18_RS10990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C7S18_RS10995	COG2205	protein histidine kinase activity
C7S18_RS11000	COG0006	proline dipeptidase activity
C7S18_RS11030	COG0577	efflux transmembrane transporter activity
C7S18_RS11030	COG1136	(ABC) transporter
C7S18_RS11035	COG1136	(ABC) transporter
C7S18_RS11035	COG0577	efflux transmembrane transporter activity
C7S18_RS11075	COG0408	coproporphyrinogen oxidase activity
C7S18_RS11080	COG1968	undecaprenyl-diphosphatase activity
C7S18_RS11090	COG0493	'glutamate synthase
C7S18_RS11095	COG0070	glutamate synthase
C7S18_RS11095	COG0067	glutamate synthase
C7S18_RS11095	COG0069	glutamate synthase activity
C7S18_RS11100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S18_RS11120	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C7S18_RS11125	COG0024	Methionine aminopeptidase
C7S18_RS11140	COG0436	Aminotransferase
C7S18_RS11150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7S18_RS11170	COG0739	heme binding
C7S18_RS11175	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C7S18_RS11185	COG1643	Atp-dependent helicase
C7S18_RS11215	COG2070	2-Nitropropane dioxygenase
C7S18_RS11215	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C7S18_RS11260	COG4771	TonB-dependent receptor
C7S18_RS11280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7S18_RS11305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7S18_RS11365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7S18_RS11395	COG0443	Heat shock 70 kDa protein
C7S18_RS11435	COG0564	pseudouridine synthase activity
C7S18_RS11455	COG2304	oxidoreductase activity
C7S18_RS11460	COG2818	Glycosylase
C7S18_RS11475	COG0028	Belongs to the TPP enzyme family
C7S18_RS11480	COG1304	FMN binding
C7S18_RS11495	COG0473	3-isopropylmalate dehydrogenase activity
C7S18_RS11505	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7S18_RS11510	COG2920	part of a sulfur-relay system
C7S18_RS11530	COG0745	RESPONSE REGULATOR receiver
C7S18_RS11550	COG4948	Mandelate Racemase Muconate Lactonizing
C7S18_RS11560	COG1301	dicarboxylic acid transport
C7S18_RS11575	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C7S18_RS11585	COG1278	Cold shock
C7S18_RS11605	COG1381	Involved in DNA repair and RecF pathway recombination
C7S18_RS11610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C7S18_RS11625	COG0681	Belongs to the peptidase S26 family
C7S18_RS11635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S18_RS11665	COG1024	Enoyl-CoA hydratase
C7S18_RS11665	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7S18_RS11670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7S18_RS11710	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C7S18_RS11715	COG4104	PAAR repeat-containing protein
C7S18_RS11725	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C7S18_RS11750	COG1960	acyl-CoA dehydrogenase activity
C7S18_RS11760	COG0529	Catalyzes the synthesis of activated sulfate
C7S18_RS11760	COG2046	Belongs to the sulfate adenylyltransferase family
C7S18_RS11770	COG3437	response regulator, receiver
C7S18_RS11770	COG0784	Response regulator, receiver
C7S18_RS11775	COG4191	Histidine kinase
C7S18_RS11775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7S18_RS11790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C7S18_RS11815	COG0243	molybdopterin cofactor binding
C7S18_RS11845	COG1309	transcriptional regulator
C7S18_RS11850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C7S18_RS11850	COG4651	solute:proton antiporter activity
C7S18_RS11890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7S18_RS11960	COG2205	protein histidine kinase activity
C7S18_RS11970	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C7S18_RS11975	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C7S18_RS11985	COG2226	methyltransferase
C7S18_RS12045	COG0714	Associated with various cellular activities
C7S18_RS12085	COG2815	serine threonine protein kinase
C7S18_RS12085	COG0515	serine threonine protein kinase
C7S18_RS12095	COG0252	asparaginase activity
C7S18_RS12105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S18_RS12110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7S18_RS12340	COG2801	Transposase and inactivated derivatives
C7S18_RS12380	COG1404	Belongs to the peptidase S8 family
C7S18_RS12415	COG1404	Belongs to the peptidase S8 family
C7S18_RS12430	COG0640	Transcriptional regulator
C7S18_RS12435	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7S18_RS12485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C7S18_RS12490	COG1466	dna polymerase III delta subunit
C7S18_RS12500	COG0495	leucyl-tRNA aminoacylation
C7S18_RS12510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7S18_RS12515	COG1288	antiporter activity
C7S18_RS12560	COG0351	phosphomethylpyrimidine kinase
C7S18_RS12565	COG3844	kynureninase activity
C7S18_RS12575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7S18_RS12585	COG2135	peptidase activity
C7S18_RS12600	COG0077	Prephenate dehydratase
C7S18_RS12600	COG1605	Chorismate mutase
C7S18_RS12605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7S18_RS12610	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C7S18_RS12620	COG0415	Belongs to the DNA photolyase family
C7S18_RS12640	COG2197	response regulator
C7S18_RS12660	COG0129	dihydroxy-acid dehydratase activity
C7S18_RS12685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C7S18_RS12700	COG0704	Plays a role in the regulation of phosphate uptake
C7S18_RS12715	COG0573	inorganic phosphate transmembrane transporter activity
C7S18_RS12720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7S18_RS12735	COG1923	regulation of RNA biosynthetic process
C7S18_RS12740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C7S18_RS12745	COG0330	HflC and HflK could
C7S18_RS12750	COG0330	HflC and HflK could
C7S18_RS12760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C7S18_RS12790	COG0556	nucleotide-excision repair
C7S18_RS12815	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C7S18_RS12820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7S18_RS12825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7S18_RS12835	COG2096	Adenosyltransferase
C7S18_RS12840	COG0123	including yeast histone deacetylase and acetoin utilization protein
C7S18_RS12850	COG1960	acyl-CoA dehydrogenase activity
C7S18_RS12865	COG3047	cAMP biosynthetic process
C7S18_RS12870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C7S18_RS12880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7S18_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS12905	COG0515	serine threonine protein kinase
C7S18_RS12920	COG0697	spore germination
C7S18_RS12930	COG1301	dicarboxylic acid transport
C7S18_RS12935	COG3540	Alkaline phosphatase
C7S18_RS12985	COG2259	Doxx family
C7S18_RS13000	COG4953	penicillin-binding protein 1C
C7S18_RS13005	COG1538	Outer membrane efflux protein
C7S18_RS13010	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7S18_RS13020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7S18_RS13035	COG1758	RNA polymerase activity
C7S18_RS13055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C7S18_RS13055	COG2755	lipolytic protein G-D-S-L family
C7S18_RS13090	COG0714	Associated with various cellular activities
C7S18_RS13130	COG2154	pterin-4-alpha-carbinolamine dehydratase
C7S18_RS13135	COG0799	negative regulation of ribosome biogenesis
C7S18_RS13140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7S18_RS13155	COG1469	GTP cyclohydrolase I activity
C7S18_RS13170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C7S18_RS13175	COG0402	S-adenosylhomocysteine deaminase activity
C7S18_RS13180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7S18_RS13185	COG1509	lysine 2,3-aminomutase activity
C7S18_RS13190	COG5001	Diguanylate cyclase
C7S18_RS13195	COG1082	Xylose isomerase domain protein TIM barrel
C7S18_RS13235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C7S18_RS13260	COG0697	spore germination
C7S18_RS13280	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS13295	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS13325	COG4191	Histidine kinase
C7S18_RS13325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7S18_RS13330	COG2252	PERMEase
C7S18_RS13360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7S18_RS13375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C7S18_RS13380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7S18_RS13420	COG0596	Alpha beta hydrolase
C7S18_RS13420	COG2226	methyltransferase
C7S18_RS13420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C7S18_RS13440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7S18_RS13445	COG0154	amidase activity
C7S18_RS13450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7S18_RS13455	COG1077	Cell shape determining protein MreB Mrl
C7S18_RS13460	COG1792	Involved in formation and maintenance of cell shape
C7S18_RS13470	COG0768	penicillin binding
C7S18_RS13475	COG0772	Belongs to the SEDS family
C7S18_RS13480	COG1714	RDD family
C7S18_RS13495	COG0463	Glycosyl transferase, family 2
C7S18_RS13500	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C7S18_RS13520	COG1286	toxin biosynthetic process
C7S18_RS13530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C7S18_RS13535	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C7S18_RS13545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7S18_RS13550	COG0521	Mo-molybdopterin cofactor biosynthetic process
C7S18_RS13555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7S18_RS13565	COG1131	(ABC) transporter
C7S18_RS13580	COG4771	TonB-dependent receptor
C7S18_RS13590	COG0358	DNA primase activity
C7S18_RS13615	COG0784	Response regulator, receiver
C7S18_RS13615	COG3437	response regulator, receiver
C7S18_RS13655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7S18_RS13665	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C7S18_RS13670	COG0235	Class ii aldolase
C7S18_RS13685	COG0105	UTP biosynthetic process
C7S18_RS13690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C7S18_RS13710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7S18_RS13715	COG1160	GTP binding
C7S18_RS13730	COG2815	serine threonine protein kinase
C7S18_RS13730	COG0515	serine threonine protein kinase
C7S18_RS13735	COG1073	alpha beta
C7S18_RS13740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7S18_RS13745	COG1420	regulation of RNA biosynthetic process
C7S18_RS13750	COG1404	Belongs to the peptidase S8 family
C7S18_RS13790	COG0625	glutathione transferase activity
C7S18_RS13795	COG2857	Cytochrome c1
C7S18_RS13800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C7S18_RS13805	COG0723	plastoquinol--plastocyanin reductase activity
C7S18_RS13810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S18_RS13815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7S18_RS13830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7S18_RS13835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7S18_RS13840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7S18_RS13845	COG0268	Binds directly to 16S ribosomal RNA
C7S18_RS13870	COG1228	amidohydrolase
C7S18_RS13880	COG2201	protein-glutamate methylesterase activity
C7S18_RS13885	COG0643	Histidine kinase
C7S18_RS13885	COG0784	Response regulator, receiver
C7S18_RS13885	COG2198	Histidine kinase
C7S18_RS13895	COG0840	transmembrane signaling receptor activity
C7S18_RS13910	COG0189	ligase activity
C7S18_RS13985	COG1518	maintenance of DNA repeat elements
C7S18_RS13985	COG1468	defense response to virus
C7S18_RS14025	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C7S18_RS14030	COG0009	L-threonylcarbamoyladenylate synthase
C7S18_RS14035	COG0859	PFAM glycosyl transferase family 9
C7S18_RS14070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7S18_RS14080	COG0315	cyclic pyranopterin monophosphate synthase activity
C7S18_RS14090	COG0314	molybdopterin synthase activity
C7S18_RS14100	COG1131	(ABC) transporter
C7S18_RS14105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7S18_RS14115	COG0386	Belongs to the glutathione peroxidase family
C7S18_RS14120	COG1874	Beta-galactosidase
C7S18_RS14120	COG0366	Alpha amylase catalytic
C7S18_RS14145	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7S18_RS14150	COG0366	Alpha amylase catalytic
C7S18_RS14155	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C7S18_RS14160	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C7S18_RS14190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C7S18_RS14205	COG1609	Transcriptional regulator
C7S18_RS14210	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C7S18_RS14215	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS14220	COG2703	oxygen carrier activity
C7S18_RS14235	COG0492	ferredoxin-NADP+ reductase activity
C7S18_RS14260	COG0037	tRNA processing
C7S18_RS14270	COG0142	geranyltranstransferase activity
C7S18_RS14280	COG2815	serine threonine protein kinase
C7S18_RS14280	COG0515	serine threonine protein kinase
C7S18_RS14295	COG2270	Major facilitator Superfamily
C7S18_RS14325	COG0625	glutathione transferase activity
C7S18_RS14340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7S18_RS14360	COG1555	photosystem II stabilization
C7S18_RS14370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7S18_RS14375	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7S18_RS14385	COG0515	serine threonine protein kinase
C7S18_RS14385	COG2815	serine threonine protein kinase
C7S18_RS14390	COG0583	DNA-binding transcription factor activity
C7S18_RS14395	COG1064	alcohol dehydrogenase
C7S18_RS14405	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C7S18_RS14415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C7S18_RS14435	COG3275	phosphorelay sensor kinase activity
C7S18_RS14445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S18_RS14460	COG0515	serine threonine protein kinase
C7S18_RS14460	COG2815	serine threonine protein kinase
C7S18_RS14470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C7S18_RS14480	COG0513	Belongs to the DEAD box helicase family
C7S18_RS14485	COG1090	epimerase
C7S18_RS14495	COG3738	Protein conserved in bacteria
C7S18_RS14500	COG1216	Glycosyl transferase, family 2
C7S18_RS14510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S18_RS14520	COG2205	protein histidine kinase activity
C7S18_RS14520	COG0745	RESPONSE REGULATOR receiver
C7S18_RS14520	COG3292	Two component regulator propeller
C7S18_RS14530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S18_RS14545	COG2815	serine threonine protein kinase
C7S18_RS14545	COG0515	serine threonine protein kinase
C7S18_RS14555	COG3588	fructose-bisphosphate aldolase
C7S18_RS14570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7S18_RS14590	COG4771	TonB-dependent receptor
C7S18_RS14670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7S18_RS14685	COG2801	Transposase and inactivated derivatives
C7S18_RS14700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7S18_RS14765	COG1131	(ABC) transporter
C7S18_RS14775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7S18_RS14795	COG2815	serine threonine protein kinase
C7S18_RS14795	COG0515	serine threonine protein kinase
C7S18_RS14805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C7S18_RS14815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7S18_RS14820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7S18_RS14845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7S18_RS14845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7S18_RS14855	COG2900	Belongs to the SlyX family
C7S18_RS14870	COG0489	protein tyrosine kinase activity
C7S18_RS14875	COG1596	polysaccharide export
C7S18_RS14895	COG0688	phosphatidylethanolamine metabolic process
C7S18_RS14905	COG2890	protein-(glutamine-N5) methyltransferase activity
C7S18_RS14910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7S18_RS14915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7S18_RS14925	COG0101	tRNA pseudouridine synthase activity
C7S18_RS14930	COG0135	phosphoribosylanthranilate isomerase activity
C7S18_RS14935	COG1253	flavin adenine dinucleotide binding
C7S18_RS14960	COG1534	Rna-binding protein
C7S18_RS14965	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C7S18_RS14970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7S18_RS14980	COG2815	serine threonine protein kinase
C7S18_RS14980	COG0515	serine threonine protein kinase
C7S18_RS15005	COG2815	serine threonine protein kinase
C7S18_RS15005	COG0515	serine threonine protein kinase
C7S18_RS15045	COG1309	transcriptional regulator
C7S18_RS15055	COG1960	acyl-CoA dehydrogenase activity
C7S18_RS15080	COG3217	Mosc domain protein beta barrel domain protein
C7S18_RS15080	COG0633	Ferredoxin
C7S18_RS15110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C7S18_RS15115	COG0860	N-Acetylmuramoyl-L-alanine amidase
C7S18_RS15125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C7S18_RS15135	COG4452	Inner membrane protein CreD
C7S18_RS15160	COG3278	Belongs to the heme-copper respiratory oxidase family
C7S18_RS15165	COG1612	heme a metabolic process
C7S18_RS15175	COG3104	oligopeptide transport
C7S18_RS15245	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C7S18_RS15255	COG0745	RESPONSE REGULATOR receiver
C7S18_RS15280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7S18_RS15290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C7S18_RS15300	COG2264	protein methyltransferase activity
C7S18_RS15305	COG0439	Biotin carboxylase
C7S18_RS15310	COG0511	ligase activity, forming carbon-carbon bonds
C7S18_RS15315	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C7S18_RS15345	COG0515	serine threonine protein kinase
C7S18_RS15345	COG2815	serine threonine protein kinase
C7S18_RS15370	COG2084	Dehydrogenase
C7S18_RS15400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C7S18_RS15420	COG3128	pkhd-type hydroxylase
C7S18_RS15425	COG3128	pkhd-type hydroxylase
C7S18_RS15515	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C7S18_RS15540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C7S18_RS15545	COG2351	hydroxyisourate hydrolase activity
C7S18_RS15555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C7S18_RS15560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7S18_RS15560	COG4191	Histidine kinase
C7S18_RS15565	COG2890	protein-(glutamine-N5) methyltransferase activity
C7S18_RS15575	COG1187	pseudouridine synthase activity
C7S18_RS15590	COG0644	oxidoreductase
C7S18_RS15615	COG1136	(ABC) transporter
C7S18_RS15615	COG0577	efflux transmembrane transporter activity
C7S18_RS15640	COG0793	Belongs to the peptidase S41A family
C7S18_RS15640	COG4946	Tricorn protease homolog
C7S18_RS15680	COG2815	serine threonine protein kinase
C7S18_RS15680	COG0515	serine threonine protein kinase
C7S18_RS15745	COG2124	cytochrome p450
C7S18_RS15770	COG0515	serine threonine protein kinase
C7S18_RS15770	COG2815	serine threonine protein kinase
C7S18_RS15800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7S18_RS15815	COG1404	Belongs to the peptidase S8 family
C7S18_RS15910	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C7S18_RS15915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C7S18_RS15920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C7S18_RS15920	COG1565	acr, cog1565
C7S18_RS15940	COG0471	metal ion transport
C7S18_RS15950	COG2204	response regulator
C7S18_RS15970	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C7S18_RS15975	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C7S18_RS15980	COG1472	Belongs to the glycosyl hydrolase 3 family
C7S18_RS15985	COG2954	triphosphatase activity
C7S18_RS15990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7S18_RS15995	COG3209	COG3209 Rhs family protein
C7S18_RS16015	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C7S18_RS16020	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C7S18_RS16025	COG0203	ribosomal protein L17
C7S18_RS16040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C7S18_RS16050	COG0201	protein transport
C7S18_RS16055	COG0200	Binds to the 23S rRNA
C7S18_RS16060	COG1841	ribosomal large subunit assembly
C7S18_RS16065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7S18_RS16070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C7S18_RS16080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7S18_RS16085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7S18_RS16090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7S18_RS16095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7S18_RS16110	COG0255	Belongs to the universal ribosomal protein uL29 family
C7S18_RS16115	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C7S18_RS16120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7S18_RS16125	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7S18_RS16130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7S18_RS16135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7S18_RS16140	COG0089	rRNA binding
C7S18_RS16150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7S18_RS16160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7S18_RS16165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7S18_RS16170	COG0049	tRNA binding
C7S18_RS16175	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C7S18_RS16180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C7S18_RS16185	COG0085	RNA polymerase activity
C7S18_RS16190	COG0222	ribosome binding
C7S18_RS16195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7S18_RS16200	COG0081	regulation of translation
C7S18_RS16205	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C7S18_RS16215	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7S18_RS16225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7S18_RS16245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C7S18_RS16285	COG0346	lactoylglutathione lyase activity
C7S18_RS16305	COG0196	riboflavin kinase activity
C7S18_RS16340	COG1263	PTS System
C7S18_RS16340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7S18_RS16345	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7S18_RS16345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7S18_RS16350	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C7S18_RS16360	COG2188	Transcriptional regulator
C7S18_RS16365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7S18_RS16370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7S18_RS16385	COG1053	succinate dehydrogenase
C7S18_RS16400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7S18_RS16405	COG0052	Belongs to the universal ribosomal protein uS2 family
C7S18_RS16420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7S18_RS16450	COG0739	heme binding
C7S18_RS16470	COG3179	chitinase
C7S18_RS16490	COG2198	Histidine kinase
C7S18_RS16490	COG0643	Histidine kinase
C7S18_RS16495	COG0840	transmembrane signaling receptor activity
C7S18_RS16510	COG0745	RESPONSE REGULATOR receiver
C7S18_RS16520	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C7S18_RS16520	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C7S18_RS16525	COG3608	succinylglutamate desuccinylase aspartoacylase
C7S18_RS16525	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C7S18_RS16540	COG2902	Dehydrogenase
C7S18_RS16555	COG0861	Integral membrane protein TerC family
C7S18_RS16570	COG0242	peptide deformylase activity
C7S18_RS16575	COG0308	aminopeptidase N
C7S18_RS16585	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C7S18_RS16590	COG2972	Histidine kinase
C7S18_RS16590	COG0745	RESPONSE REGULATOR receiver
C7S18_RS16605	COG0515	serine threonine protein kinase
C7S18_RS16605	COG2815	serine threonine protein kinase
C7S18_RS16610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C7S18_RS16610	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7S18_RS16615	COG0189	ligase activity
C7S18_RS16615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C7S18_RS16655	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C7S18_RS16685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C7S18_RS16690	COG0248	Ppx GppA phosphatase
C7S18_RS16695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7S18_RS16705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C7S18_RS16715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C7S18_RS16715	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C7S18_RS16735	COG0617	tRNA 3'-terminal CCA addition
C7S18_RS16760	COG0697	spore germination
C7S18_RS16805	COG2957	Belongs to the agmatine deiminase family
C7S18_RS16810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7S18_RS16880	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C7S18_RS16885	COG0583	DNA-binding transcription factor activity
C7S18_RS16890	COG3634	alkyl hydroperoxide reductase activity
C7S18_RS16905	COG4206	TonB-dependent receptor
C7S18_RS16915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7S18_RS16940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7S18_RS16945	COG0740	serine-type endopeptidase activity
C7S18_RS16950	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7S18_RS16995	COG0318	PFAM AMP-dependent synthetase and ligase
C7S18_RS17010	COG1404	Belongs to the peptidase S8 family
C7S18_RS17050	COG0174	glutamine synthetase
C7S18_RS17085	COG0596	Alpha beta hydrolase
C7S18_RS17090	COG1136	(ABC) transporter
C7S18_RS17090	COG0577	efflux transmembrane transporter activity
C7S18_RS17105	COG1136	(ABC) transporter
C7S18_RS17105	COG0577	efflux transmembrane transporter activity
C7S18_RS17120	COG0606	chelatase, subunit chli
C7S18_RS17145	COG0210	DNA helicase
C7S18_RS17150	COG0657	acetylesterase activity
C7S18_RS17155	COG4585	Histidine kinase
C7S18_RS17160	COG0515	serine threonine protein kinase
C7S18_RS17160	COG2815	serine threonine protein kinase
C7S18_RS17170	COG0564	pseudouridine synthase activity
C7S18_RS17180	COG0343	queuine tRNA-ribosyltransferase activity
C7S18_RS17185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C7S18_RS17215	COG2815	serine threonine protein kinase
C7S18_RS17215	COG0515	serine threonine protein kinase
C7S18_RS17225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_RS17270	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C7S18_RS17275	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C7S18_RS17300	COG1404	Belongs to the peptidase S8 family
C7S18_RS17345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7S18_RS17370	COG1136	(ABC) transporter
C7S18_RS17370	COG0577	efflux transmembrane transporter activity
C7S18_RS17375	COG1136	(ABC) transporter
C7S18_RS17375	COG0577	efflux transmembrane transporter activity
C7S18_RS17380	COG1136	(ABC) transporter
C7S18_RS17380	COG0577	efflux transmembrane transporter activity
C7S18_RS17390	COG1136	(ABC) transporter
C7S18_RS17390	COG0577	efflux transmembrane transporter activity
C7S18_RS17405	COG1609	Transcriptional regulator
C7S18_RS17410	COG2211	Major facilitator Superfamily
C7S18_RS17415	COG2723	6-phospho-beta-galactosidase activity
C7S18_RS17420	COG4771	TonB-dependent receptor
C7S18_RS17440	COG3119	arylsulfatase activity
C7S18_RS17450	COG0126	phosphoglycerate kinase activity
C7S18_RS17455	COG0469	pyruvate kinase activity
C7S18_RS17480	COG0515	serine threonine protein kinase
C7S18_RS17480	COG2815	serine threonine protein kinase
C7S18_RS17500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7S18_RS17510	COG2204	response regulator
C7S18_RS17515	COG3300	MHYT domain
C7S18_RS17515	COG5001	Diguanylate cyclase
C7S18_RS17535	COG0109	protoheme IX farnesyltransferase activity
C7S18_RS17560	COG1960	acyl-CoA dehydrogenase activity
C7S18_RS17575	COG2937	Belongs to the GPAT DAPAT family
C7S18_RS17625	COG0793	Belongs to the peptidase S41A family
C7S18_RS17635	COG2234	aminopeptidase activity
C7S18_RS17655	COG0515	serine threonine protein kinase
C7S18_RS17655	COG2815	serine threonine protein kinase
C7S18_RS17685	COG2204	response regulator
C7S18_RS17720	COG3039	Transposase
C7S18_RS17840	COG0346	lactoylglutathione lyase activity
C7S18_RS17855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7S18_RS17860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C7S18_RS17865	COG0300	oxidoreductase activity
C7S18_RS17870	COG2095	MarC family integral membrane protein
C7S18_RS17880	COG1215	transferase activity, transferring glycosyl groups
C7S18_RS17890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7S18_RS17925	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS17935	COG2205	protein histidine kinase activity
C7S18_RS17935	COG2198	Histidine kinase
C7S18_RS17935	COG0784	Response regulator, receiver
C7S18_RS17950	COG2610	gluconate transmembrane transporter activity
C7S18_RS17960	COG1716	ATPase activity
C7S18_RS17995	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7S18_RS18000	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C7S18_RS18005	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C7S18_RS18010	COG0813	purine-nucleoside phosphorylase activity
C7S18_RS18015	COG0537	adenosine 5'-monophosphoramidase activity
C7S18_RS18020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7S18_RS18025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C7S18_RS18030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C7S18_RS18065	COG1131	(ABC) transporter
C7S18_RS18070	COG0842	Transport permease protein
C7S18_RS18080	COG0346	lactoylglutathione lyase activity
C7S18_RS18125	COG0784	Response regulator, receiver
C7S18_RS18125	COG2205	protein histidine kinase activity
C7S18_RS18125	COG2198	Histidine kinase
C7S18_RS18125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7S18_RS18135	COG3038	cytochrome b561
C7S18_RS18150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C7S18_RS18170	COG0084	hydrolase, TatD family'
C7S18_RS18190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C7S18_RS18200	COG2084	Dehydrogenase
C7S18_RS18225	COG4585	Histidine kinase
C7S18_RS18230	COG2197	response regulator
C7S18_RS18240	COG1131	(ABC) transporter
C7S18_RS18260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7S18_RS18265	COG1946	Acyl-CoA thioesterase
C7S18_RS18275	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C7S18_RS18285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7S18_RS18285	COG0784	Response regulator, receiver
C7S18_RS18285	COG2205	protein histidine kinase activity
C7S18_RS18285	COG2198	Histidine kinase
C7S18_RS18290	COG1272	protein, Hemolysin III
C7S18_RS18320	COG2815	serine threonine protein kinase
C7S18_RS18320	COG0515	serine threonine protein kinase
C7S18_RS18330	COG0515	serine threonine protein kinase
C7S18_RS18330	COG2815	serine threonine protein kinase
C7S18_RS18340	COG0501	Belongs to the peptidase M48B family
C7S18_RS18345	COG1704	LemA family
C7S18_RS18370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C7S18_RS18400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C7S18_RS18405	COG0706	membrane insertase activity
C7S18_RS18410	COG0594	ribonuclease P activity
C7S18_RS18415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C7S18_RS18430	COG2205	protein histidine kinase activity
C7S18_RS18435	COG0745	RESPONSE REGULATOR receiver
C7S18_RS18450	COG2833	Protein of unknown function (DUF455)
C7S18_RS18480	COG0412	Dienelactone hydrolase
C7S18_RS18525	COG0247	lactate metabolic process
C7S18_RS18535	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C7S18_RS18540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7S18_RS18570	COG0442	prolyl-tRNA aminoacylation
C7S18_RS18575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7S18_RS18590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7S18_RS18600	COG0515	serine threonine protein kinase
C7S18_RS18600	COG2815	serine threonine protein kinase
C7S18_RS18605	COG0515	serine threonine protein kinase
C7S18_RS18625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C7S18_RS18705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S18_RS18740	COG3300	MHYT domain
C7S18_RS18740	COG5001	Diguanylate cyclase
C7S18_RS18745	COG2925	Exonuclease
C7S18_RS18750	COG0515	serine threonine protein kinase
C7S18_RS18750	COG2815	serine threonine protein kinase
C7S18_RS18760	COG4251	negative regulation of phosphorylation
C7S18_RS18760	COG3706	GGDEF domain
C7S18_RS18760	COG2203	Gaf domain
C7S18_RS18760	COG5001	Diguanylate cyclase
C7S18_RS18795	COG4682	membrane
C7S18_RS18805	COG0210	DNA helicase
C7S18_RS18920	COG3547	Transposase (IS116 IS110 IS902 family)
C7S18_RS18955	COG3795	YCII-related domain
C7S18_RS18990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7S18_RS18995	COG2205	protein histidine kinase activity
C7S18_RS19000	COG4771	TonB-dependent receptor
C7S18_RS19010	COG0436	Aminotransferase
C7S18_RS19030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C7S18_RS19045	COG3227	Zinc metalloprotease (Elastase)
C7S18_RS19050	COG3813	Protein conserved in bacteria
C7S18_RS19055	COG2894	cell division
C7S18_RS19060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S18_RS19075	COG0438	transferase activity, transferring glycosyl groups
C7S18_RS19140	COG0284	orotidine-5'-phosphate decarboxylase activity
C7S18_RS19235	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C7S18_RS19235	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C7S18_RS19305	COG0783	Belongs to the Dps family
C7S18_RS19310	COG1643	Atp-dependent helicase
C7S18_RS19330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7S18_RS19335	COG0719	Fe-S assembly protein
C7S18_RS19340	COG0396	ATPase activity
C7S18_RS19350	COG0719	Fe-S assembly protein
C7S18_RS19355	COG1959	2 iron, 2 sulfur cluster binding
C7S18_RS19370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C7S18_RS19375	COG0583	DNA-binding transcription factor activity
C7S18_RS19380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7S18_RS19380	COG1648	precorrin-2 dehydrogenase activity
C7S18_RS19415	COG4783	chaperone-mediated protein folding
C7S18_RS19470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7S18_RS19485	COG0437	4 iron, 4 sulfur cluster binding
C7S18_RS19590	COG0745	RESPONSE REGULATOR receiver
C7S18_RS19650	COG1902	pentaerythritol trinitrate reductase activity
C7S18_RS19655	COG1309	transcriptional regulator
C7S18_RS19685	COG2885	chlorophyll binding
C7S18_RS19685	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C7S18_RS19835	COG3279	Response regulator of the LytR AlgR family
C7S18_RS19840	COG3275	phosphorelay sensor kinase activity
C7S18_RS19965	COG3039	Transposase
C7S18_RS19970	COG0318	PFAM AMP-dependent synthetase and ligase
C7S18_RS19975	COG3039	Transposase
C7S18_RS19990	COG0318	PFAM AMP-dependent synthetase and ligase
C7S18_RS19995	COG0302	gtp cyclohydrolase
C7S18_RS20000	COG1132	(ABC) transporter
C7S18_RS20005	COG4585	Histidine kinase
C7S18_RS20030	COG0457	Tetratricopeptide repeat
C7S18_RS20120	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C7S18_RS20125	COG5000	phosphorelay sensor kinase activity
C7S18_RS20135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7S18_RS20135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7S18_RS20140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7S18_RS20150	COG0183	Belongs to the thiolase family
C7S18_RS20165	COG2824	Alkylphosphonate utilization operon protein PhnA
C7S18_RS20230	COG0708	Exodeoxyribonuclease III
C7S18_RS20245	COG3706	GGDEF domain
C7S18_RS20245	COG4251	negative regulation of phosphorylation
C7S18_RS20245	COG5001	Diguanylate cyclase
C7S18_RS20245	COG2203	Gaf domain
C7S18_RS20295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_RS20320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_RS20365	COG3012	SEC-C Motif Domain Protein
C7S18_RS20370	COG0515	serine threonine protein kinase
C7S18_RS20370	COG2815	serine threonine protein kinase
C7S18_RS20385	COG0187	DNA topoisomerase II activity
C7S18_RS20390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7S18_RS20395	COG0592	DNA-directed DNA polymerase activity
C7S18_RS20400	COG4585	Histidine kinase
C7S18_RS20405	COG2197	response regulator
C7S18_RS20410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7S18_RS20415	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C7S18_RS20455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C7S18_RS20475	COG2003	Belongs to the UPF0758 family
C7S18_RS20485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S18_RS20515	COG0457	Tetratricopeptide repeat
C7S18_RS20515	COG0515	serine threonine protein kinase
C7S18_RS20530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7S18_RS20535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C7S18_RS20550	COG0842	Transport permease protein
C7S18_RS20555	COG1131	(ABC) transporter
C7S18_RS20560	COG1714	RDD family
C7S18_RS20565	COG2922	Belongs to the Smg family
C7S18_RS20570	COG0758	DNA mediated transformation
C7S18_RS20590	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C7S18_RS20590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7S18_RS20595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7S18_RS20595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7S18_RS20620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7S18_RS20635	COG4115	mRNA cleavage
C7S18_RS20645	COG1024	Enoyl-CoA hydratase
C7S18_RS20655	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C7S18_RS20690	COG0577	efflux transmembrane transporter activity
C7S18_RS20690	COG1136	(ABC) transporter
C7S18_RS20705	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C7S18_RS20710	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C7S18_RS20710	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C7S18_RS20715	COG0626	cystathionine gamma-synthase activity
C7S18_RS20725	COG3186	Phenylalanine-4-hydroxylase
C7S18_RS20755	COG0456	acetyltransferase
C7S18_RS20760	COG0632	four-way junction helicase activity
C7S18_RS20770	COG0217	transcriptional regulatory protein
C7S18_RS20780	COG1131	(ABC) transporter
C7S18_RS20790	COG2205	protein histidine kinase activity
C7S18_RS20865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_RS20900	COG1011	Hydrolase
C7S18_RS20905	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7S18_RS20920	COG4585	Histidine kinase
C7S18_RS20930	COG2197	response regulator
C7S18_RS20960	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C7S18_RS20975	COG1956	GAF domain-containing protein
C7S18_RS20985	COG0625	glutathione transferase activity
C7S18_RS21010	COG0583	DNA-binding transcription factor activity
C7S18_RS21015	COG2268	Band 7 protein
C7S18_RS21045	COG3850	Histidine kinase
C7S18_RS21045	COG3437	response regulator, receiver
C7S18_RS21045	COG4999	Histidine kinase
C7S18_RS21045	COG2205	protein histidine kinase activity
C7S18_RS21070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C7S18_RS21075	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C7S18_RS21080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7S18_RS21090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7S18_RS21105	COG2183	response to ionizing radiation
C7S18_RS21110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C7S18_RS21120	COG2072	flavoprotein involved in K transport
C7S18_RS21135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7S18_RS21140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7S18_RS21165	COG3039	Transposase
C7S18_RS21235	COG1561	YicC-like family, N-terminal region
C7S18_RS21240	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C7S18_RS21330	COG3039	Transposase
C7S18_RS21340	COG2234	aminopeptidase activity
C7S18_RS21345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7S18_RS21350	COG0577	efflux transmembrane transporter activity
C7S18_RS21355	COG1741	Belongs to the pirin family
C7S18_RS21370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C7S18_RS21370	COG0543	2 iron, 2 sulfur cluster binding
C7S18_RS21375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7S18_RS21390	COG1473	amidohydrolase
C7S18_RS21420	COG1752	Esterase of the alpha-beta hydrolase superfamily
C7S18_RS21425	COG4585	Histidine kinase
C7S18_RS21430	COG2197	response regulator
C7S18_RS21435	COG3590	peptidase
C7S18_RS21465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7S18_RS21500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7S18_RS21505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7S18_RS21520	COG1802	Transcriptional regulator
C7S18_RS21545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7S18_RS21570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7S18_RS21575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7S18_RS21605	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C7S18_RS21610	COG0667	Aldo Keto reductase
C7S18_RS21615	COG3034	peptidoglycan biosynthetic process
C7S18_RS21620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C7S18_RS21625	COG0626	cystathionine gamma-synthase activity
C7S18_RS21635	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C7S18_RS21645	COG0668	transmembrane transport
C7S18_RS21650	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C7S18_RS21655	COG0352	thiamine-phosphate diphosphorylase activity
C7S18_RS21660	COG1773	rubredoxin
C7S18_RS21680	COG2816	NAD+ diphosphatase activity
C7S18_RS21685	COG3132	Protein of unknown function, DUF480
C7S18_RS21690	COG1678	Uncharacterized ACR, COG1678
C7S18_RS21700	COG1205	dead DEAH box helicase
C7S18_RS21700	COG1111	helicase
C7S18_RS21715	COG0577	efflux transmembrane transporter activity
C7S18_RS21715	COG1136	(ABC) transporter
C7S18_RS21720	COG1136	(ABC) transporter
C7S18_RS21720	COG0577	efflux transmembrane transporter activity
C7S18_RS21725	COG1136	(ABC) transporter
C7S18_RS21750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C7S18_RS21755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7S18_RS21760	COG0628	permease
C7S18_RS21765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C7S18_RS21775	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C7S18_RS21780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C7S18_RS21790	COG0318	PFAM AMP-dependent synthetase and ligase
C7S18_RS21805	COG0792	nuclease activity
C7S18_RS21810	COG0277	FAD linked oxidase domain protein
C7S18_RS21825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C7S18_RS21830	COG1461	Dihydroxyacetone kinase
C7S18_RS21870	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C7S18_RS21890	COG3708	Transcriptional regulator
C7S18_RS21890	COG2207	Transcriptional regulator
C7S18_RS21930	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C7S18_RS21935	COG0745	RESPONSE REGULATOR receiver
C7S18_RS21945	COG2884	Cell division ATP-binding protein ftsE
C7S18_RS21960	COG0540	Belongs to the ATCase OTCase family
C7S18_RS21970	COG2151	metal-sulfur cluster biosynthetic enzyme
C7S18_RS21980	COG1252	NADH dehydrogenase
C7S18_RS21985	COG1610	YqeY-like protein
C7S18_RS22005	COG0312	modulator of DNA gyrase
C7S18_RS22040	COG3409	Peptidoglycan-binding domain 1 protein
C7S18_RS22040	COG3267	Type II secretory pathway component ExeA
C7S18_RS22045	COG4942	peptidase
C7S18_RS22070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7S18_RS22070	COG0047	phosphoribosylformylglycinamidine synthase activity
C7S18_RS22080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_RS22085	COG1459	type II secretion system
C7S18_RS22095	COG4970	Tfp pilus assembly protein FimT
C7S18_RS22105	COG4795	General secretion pathway protein
C7S18_RS22110	COG3156	type II secretion system protein K
C7S18_RS22115	COG3166	PFAM Fimbrial assembly family protein
C7S18_RS22130	COG1450	Type ii and iii secretion system protein
C7S18_RS22185	COG0151	Belongs to the GarS family
C7S18_RS22215	COG1131	(ABC) transporter
C7S18_RS22255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7S18_RS22260	COG0625	glutathione transferase activity
C7S18_RS22285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7S18_RS22315	COG0037	tRNA processing
C7S18_RS22320	COG4191	Histidine kinase
C7S18_RS22325	COG2204	response regulator
C7S18_RS22335	COG1131	(ABC) transporter
C7S18_RS22340	COG0842	Transport permease protein
C7S18_RS22375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C7S18_RS22410	COG1595	DNA-templated transcription, initiation
C7S18_RS22430	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS22440	COG0017	Asparaginyl-tRNA synthetase
C7S18_RS22445	COG0316	Belongs to the HesB IscA family
C7S18_RS22450	COG0360	Binds together with S18 to 16S ribosomal RNA
C7S18_RS22455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7S18_RS22460	COG0359	binds to the 23S rRNA
C7S18_RS22465	COG3384	dioxygenase
C7S18_RS22475	COG0612	Peptidase, M16
C7S18_RS22500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7S18_RS22545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7S18_RS22575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7S18_RS22585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7S18_RS22610	COG1074	ATP-dependent DNA helicase activity
C7S18_RS22615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7S18_RS22620	COG0720	synthase
C7S18_RS22640	COG2204	response regulator
C7S18_RS22670	COG1228	amidohydrolase
C7S18_RS22675	COG3178	'Phosphotransferase
C7S18_RS22680	COG1166	arginine decarboxylase activity
C7S18_RS22695	COG0824	Thioesterase
C7S18_RS22720	COG2885	chlorophyll binding
C7S18_RS22725	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C7S18_RS22730	COG0602	queuosine metabolic process
C7S18_RS22745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C7S18_RS22765	COG4968	Prepilin-type N-terminal cleavage methylation domain
C7S18_RS22790	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS22795	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_RS22800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7S18_RS22805	COG0156	8-amino-7-oxononanoate synthase activity
C7S18_RS22840	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C7S18_RS22930	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C7S18_RS22945	COG2814	Major facilitator Superfamily
C7S18_RS23010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7S18_RS23025	COG2840	Smr protein MutS2
C7S18_RS23045	COG0110	maltose O-acetyltransferase activity
C7S18_RS23065	COG0438	transferase activity, transferring glycosyl groups
C7S18_RS23090	COG1215	transferase activity, transferring glycosyl groups
C7S18_RS23110	COG2192	nodulation
C7S18_RS23125	COG0438	transferase activity, transferring glycosyl groups
C7S18_RS23130	COG0463	Glycosyl transferase, family 2
C7S18_RS23130	COG1216	Glycosyl transferase, family 2
C7S18_RS23145	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C7S18_RS23185	COG1366	Belongs to the anti-sigma-factor antagonist family
C7S18_RS23195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7S18_RS23215	COG0356	it plays a direct role in the translocation of protons across the membrane
C7S18_RS23225	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7S18_RS23230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7S18_RS23235	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7S18_RS23245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7S18_RS23250	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C7S18_RS23275	COG0488	(ABC) transporter
C7S18_RS23285	COG0488	(ABC) transporter
C7S18_RS23290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C7S18_RS23295	COG4208	sulfate ABC transporter
C7S18_RS23300	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C7S18_RS23305	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C7S18_RS23320	COG1959	2 iron, 2 sulfur cluster binding
C7S18_RS23325	COG3038	cytochrome b561
C7S18_RS23345	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C7S18_RS23360	COG0543	2 iron, 2 sulfur cluster binding
C7S18_RS23390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7S18_RS23390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C7S18_RS23465	COG1475	DNA binding
C7S18_RS23525	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C7S18_RS23530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7S18_RS23545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C7S18_RS23600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_RS23625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_RS23685	COG1192	Involved in chromosome partitioning
C7S18_RS23745	COG0675	Transposase, IS605 OrfB family
C7S18_RS23805	COG0305	Participates in initiation and elongation during chromosome replication
C7S18_RS23815	COG0210	DNA helicase
C7S18_RS23900	COG4372	Transposase
C7S18_RS23975	COG5654	RES domain protein
C7S18_RS23985	COG0629	single-stranded DNA binding
C7S18_RS24065	COG1002	Type II restriction enzyme, methylase subunits
C7S18_RS24090	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding