locus-tag	class	description
FPL04_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FPL04_RS00025	COG0187	DNA topoisomerase II activity
FPL04_RS00035	COG0501	Belongs to the peptidase M48B family
FPL04_RS00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FPL04_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL04_RS00110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FPL04_RS00115	COG0793	Belongs to the peptidase S41A family
FPL04_RS00120	COG4942	peptidase
FPL04_RS00130	COG2234	aminopeptidase activity
FPL04_RS00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL04_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL04_RS00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL04_RS00160	COG1064	alcohol dehydrogenase
FPL04_RS00170	COG0493	'glutamate synthase
FPL04_RS00175	COG0067	glutamate synthase
FPL04_RS00175	COG0069	glutamate synthase activity
FPL04_RS00175	COG0070	glutamate synthase
FPL04_RS00205	COG3459	Glycosyltransferase 36 associated
FPL04_RS00235	COG1111	helicase
FPL04_RS00235	COG1205	dead DEAH box helicase
FPL04_RS00240	COG1272	protein, Hemolysin III
FPL04_RS00265	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS00285	COG0583	DNA-binding transcription factor activity
FPL04_RS00290	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS00305	COG1733	regulation of RNA biosynthetic process
FPL04_RS00365	COG1733	regulation of RNA biosynthetic process
FPL04_RS00370	COG3237	CsbD-like
FPL04_RS00410	COG0657	acetylesterase activity
FPL04_RS00420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL04_RS00465	COG0714	Associated with various cellular activities
FPL04_RS00495	COG0596	Alpha beta hydrolase
FPL04_RS00505	COG1309	transcriptional regulator
FPL04_RS00520	COG4772	TonB-dependent receptor
FPL04_RS00530	COG0662	Cupin 2, conserved barrel domain protein
FPL04_RS00535	COG1012	belongs to the aldehyde dehydrogenase family
FPL04_RS00565	COG1304	FMN binding
FPL04_RS00570	COG1755	Isoprenylcysteine carboxyl methyltransferase
FPL04_RS00575	COG4585	Histidine kinase
FPL04_RS00580	COG2197	response regulator
FPL04_RS00600	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FPL04_RS00705	COG0366	Alpha amylase catalytic
FPL04_RS00710	COG0366	Alpha amylase catalytic
FPL04_RS00715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL04_RS00755	COG2755	lipolytic protein G-D-S-L family
FPL04_RS00765	COG0657	acetylesterase activity
FPL04_RS00765	COG2755	lipolytic protein G-D-S-L family
FPL04_RS00775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FPL04_RS00790	COG3507	Belongs to the glycosyl hydrolase 43 family
FPL04_RS00795	COG1609	Transcriptional regulator
FPL04_RS00805	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FPL04_RS00810	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS00820	COG2755	lipolytic protein G-D-S-L family
FPL04_RS00830	COG3186	Phenylalanine-4-hydroxylase
FPL04_RS00835	COG1522	sequence-specific DNA binding
FPL04_RS00845	COG1752	Esterase of the alpha-beta hydrolase superfamily
FPL04_RS00855	COG1119	ATPase activity
FPL04_RS00870	COG1125	glycine betaine transport
FPL04_RS00870	COG0517	IMP dehydrogenase activity
FPL04_RS00885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FPL04_RS00890	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FPL04_RS00925	COG0489	protein tyrosine kinase activity
FPL04_RS00930	COG2062	phosphohistidine phosphatase, SixA
FPL04_RS00935	COG2353	YceI-like domain
FPL04_RS00940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL04_RS00965	COG1881	PFAM PEBP family protein
FPL04_RS00980	COG0174	glutamine synthetase
FPL04_RS00985	COG0347	Belongs to the P(II) protein family
FPL04_RS00990	COG0004	ammonium transporteR
FPL04_RS00995	COG3852	Histidine kinase
FPL04_RS01000	COG2204	response regulator
FPL04_RS01005	COG2032	superoxide dismutase activity
FPL04_RS01010	COG2032	superoxide dismutase activity
FPL04_RS01015	COG0346	lactoylglutathione lyase activity
FPL04_RS01025	COG0183	Belongs to the thiolase family
FPL04_RS01065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FPL04_RS01075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FPL04_RS01085	COG0028	Belongs to the TPP enzyme family
FPL04_RS01090	COG2205	protein histidine kinase activity
FPL04_RS01115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FPL04_RS01130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL04_RS01140	COG0596	Alpha beta hydrolase
FPL04_RS01145	COG0727	PFAM Uncharacterised protein family (UPF0153)
FPL04_RS01150	COG0318	PFAM AMP-dependent synthetase and ligase
FPL04_RS01165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL04_RS01200	COG0564	pseudouridine synthase activity
FPL04_RS01220	COG1446	asparaginase
FPL04_RS01225	COG0339	signal peptide processing
FPL04_RS01250	COG0475	glutathione-regulated potassium exporter activity
FPL04_RS01255	COG0583	DNA-binding transcription factor activity
FPL04_RS01260	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FPL04_RS01265	COG2224	Isocitrate lyase
FPL04_RS01295	COG4770	biotin carboxylase activity
FPL04_RS01300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FPL04_RS01305	COG1960	acyl-CoA dehydrogenase activity
FPL04_RS01360	COG0523	cobalamin synthesis protein
FPL04_RS01365	COG0697	spore germination
FPL04_RS01375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FPL04_RS01380	COG1846	Transcriptional regulator
FPL04_RS01385	COG1764	response to oxidative stress
FPL04_RS01410	COG0656	L-ascorbic acid biosynthetic process
FPL04_RS01415	COG2130	NADP-dependent
FPL04_RS01430	COG1187	pseudouridine synthase activity
FPL04_RS01440	COG1643	Atp-dependent helicase
FPL04_RS01445	COG0840	transmembrane signaling receptor activity
FPL04_RS01455	COG4807	Protein conserved in bacteria
FPL04_RS01460	COG2351	hydroxyisourate hydrolase activity
FPL04_RS01465	COG2072	flavoprotein involved in K transport
FPL04_RS01485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FPL04_RS01520	COG1957	nucleoside hydrolase
FPL04_RS01545	COG0084	hydrolase, TatD family'
FPL04_RS01555	COG0583	DNA-binding transcription factor activity
FPL04_RS01560	COG2814	Major facilitator Superfamily
FPL04_RS01590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FPL04_RS01595	COG1902	pentaerythritol trinitrate reductase activity
FPL04_RS01615	COG2223	nitrite transmembrane transporter activity
FPL04_RS01620	COG0745	RESPONSE REGULATOR receiver
FPL04_RS01625	COG2205	protein histidine kinase activity
FPL04_RS01630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_RS01650	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS01670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FPL04_RS01675	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FPL04_RS01680	COG0583	DNA-binding transcription factor activity
FPL04_RS01705	COG0702	epimerase
FPL04_RS01710	COG1733	regulation of RNA biosynthetic process
FPL04_RS01720	COG0840	transmembrane signaling receptor activity
FPL04_RS01820	COG0129	dihydroxy-acid dehydratase activity
FPL04_RS01840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FPL04_RS01845	COG2814	Major facilitator Superfamily
FPL04_RS01890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FPL04_RS01895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FPL04_RS01925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FPL04_RS01930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FPL04_RS01940	COG3485	protocatechuate 3,4-dioxygenase
FPL04_RS01945	COG3485	protocatechuate 3,4-dioxygenase
FPL04_RS01955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL04_RS01960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FPL04_RS01970	COG1414	Transcriptional regulator
FPL04_RS01985	COG0657	acetylesterase activity
FPL04_RS01995	COG0445	tRNA wobble uridine modification
FPL04_RS02005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FPL04_RS02045	COG0156	8-amino-7-oxononanoate synthase activity
FPL04_RS02050	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FPL04_RS02055	COG1040	competence protein
FPL04_RS02110	COG1511	domain protein
FPL04_RS02110	COG3264	Mechanosensitive ion channel
FPL04_RS02115	COG1368	sulfuric ester hydrolase activity
FPL04_RS02120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPL04_RS02125	COG2354	Protein conserved in bacteria
FPL04_RS02135	COG0297	glycogen (starch) synthase activity
FPL04_RS02140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL04_RS02145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL04_RS02170	COG0702	epimerase
FPL04_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS02210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL04_RS02225	COG0513	Belongs to the DEAD box helicase family
FPL04_RS02235	COG0508	dehydrogenase complex catalyzes the overall conversion of
FPL04_RS02250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FPL04_RS02265	COG3104	oligopeptide transport
FPL04_RS02285	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FPL04_RS02300	COG1320	monovalent cation:proton antiporter activity
FPL04_RS02305	COG2212	antiporter activity
FPL04_RS02315	COG0651	ATP synthesis coupled electron transport
FPL04_RS02320	COG1006	Multisubunit Na H antiporter MnhC subunit
FPL04_RS02325	COG2111	Na H antiporter
FPL04_RS02325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FPL04_RS02370	COG0484	heat shock protein binding
FPL04_RS02390	COG1597	lipid kinase activity
FPL04_RS02415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FPL04_RS02420	COG0134	indole-3-glycerol-phosphate synthase activity
FPL04_RS02430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL04_RS02450	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FPL04_RS02460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FPL04_RS02475	COG1051	belongs to the nudix hydrolase family
FPL04_RS02520	COG0316	Belongs to the HesB IscA family
FPL04_RS02535	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FPL04_RS02560	COG2814	Major facilitator Superfamily
FPL04_RS02565	COG1289	transmembrane transporter activity
FPL04_RS02570	COG0151	Belongs to the GarS family
FPL04_RS02575	COG0138	bifunctional purine biosynthesis protein purh
FPL04_RS02595	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FPL04_RS02615	COG2264	protein methyltransferase activity
FPL04_RS02630	COG0439	Biotin carboxylase
FPL04_RS02640	COG0511	ligase activity, forming carbon-carbon bonds
FPL04_RS02645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FPL04_RS02655	COG1324	tolerance protein
FPL04_RS02660	COG2356	endonuclease I
FPL04_RS02675	COG4771	TonB-dependent receptor
FPL04_RS02685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FPL04_RS02710	COG3712	iron ion homeostasis
FPL04_RS02735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FPL04_RS02765	COG2353	YceI-like domain
FPL04_RS02785	COG3052	prosthetic group binding
FPL04_RS02820	COG1802	Transcriptional regulator
FPL04_RS02825	COG0546	phosphoglycolate phosphatase activity
FPL04_RS02995	COG2207	Transcriptional regulator
FPL04_RS03000	COG0300	oxidoreductase activity
FPL04_RS03010	COG1595	DNA-templated transcription, initiation
FPL04_RS03025	COG1506	peptidase
FPL04_RS03025	COG0823	Involved in the tonB-independent uptake of proteins
FPL04_RS03065	COG0435	Glutathione S-transferase
FPL04_RS03100	COG0823	Involved in the tonB-independent uptake of proteins
FPL04_RS03100	COG1506	peptidase
FPL04_RS03150	COG0697	spore germination
FPL04_RS03165	COG4305	rare lipoprotein A
FPL04_RS03170	COG1113	amino acid transport
FPL04_RS03190	COG3507	Belongs to the glycosyl hydrolase 43 family
FPL04_RS03245	COG0840	transmembrane signaling receptor activity
FPL04_RS03250	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL04_RS03250	COG5297	Belongs to the glycosyl hydrolase family 6
FPL04_RS03255	COG0659	secondary active sulfate transmembrane transporter activity
FPL04_RS03260	COG3706	GGDEF domain
FPL04_RS03275	COG2943	transferase activity, transferring hexosyl groups
FPL04_RS03285	COG3275	phosphorelay sensor kinase activity
FPL04_RS03295	COG0181	hydroxymethylbilane synthase activity
FPL04_RS03320	COG1505	serine-type exopeptidase activity
FPL04_RS03325	COG0436	Aminotransferase
FPL04_RS03340	COG2832	Protein of unknown function (DUF454)
FPL04_RS03350	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FPL04_RS03365	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FPL04_RS03400	COG2226	methyltransferase
FPL04_RS03405	COG3300	MHYT domain
FPL04_RS03405	COG5001	Diguanylate cyclase
FPL04_RS03410	COG0308	aminopeptidase N
FPL04_RS03465	COG3284	Transcriptional regulator
FPL04_RS03470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPL04_RS03475	COG1077	Cell shape determining protein MreB Mrl
FPL04_RS03480	COG1792	Involved in formation and maintenance of cell shape
FPL04_RS03495	COG0772	Belongs to the SEDS family
FPL04_RS03510	COG2951	lytic endotransglycosylase activity
FPL04_RS03515	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FPL04_RS03520	COG1686	Belongs to the peptidase S11 family
FPL04_RS03530	COG2921	Belongs to the UPF0250 family
FPL04_RS03535	COG0321	lipoyl(octanoyl) transferase activity
FPL04_RS03540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FPL04_RS03555	COG0583	DNA-binding transcription factor activity
FPL04_RS03565	COG1051	belongs to the nudix hydrolase family
FPL04_RS03565	COG1056	cytidyltransferase-related domain
FPL04_RS03600	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FPL04_RS03605	COG0673	inositol 2-dehydrogenase activity
FPL04_RS03610	COG2823	Periplasmic or secreted lipoprotein
FPL04_RS03615	COG4251	negative regulation of phosphorylation
FPL04_RS03620	COG0784	Response regulator, receiver
FPL04_RS03625	COG4191	Histidine kinase
FPL04_RS03630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FPL04_RS03635	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS03685	COG1459	type II secretion system
FPL04_RS03700	COG2165	general secretion pathway protein
FPL04_RS03710	COG3156	type II secretion system protein K
FPL04_RS03735	COG3250	beta-galactosidase activity
FPL04_RS03750	COG2188	Transcriptional regulator
FPL04_RS03760	COG1609	Transcriptional regulator
FPL04_RS03765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPL04_RS03770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FPL04_RS03785	COG0617	tRNA 3'-terminal CCA addition
FPL04_RS03805	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FPL04_RS03810	COG1012	belongs to the aldehyde dehydrogenase family
FPL04_RS03815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FPL04_RS03825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL04_RS03840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FPL04_RS03845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FPL04_RS03860	COG2205	protein histidine kinase activity
FPL04_RS03880	COG3920	Histidine kinase
FPL04_RS03890	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FPL04_RS03895	COG3791	Glutathione-dependent formaldehyde-activating
FPL04_RS03905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL04_RS03915	COG0697	spore germination
FPL04_RS03935	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FPL04_RS03940	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FPL04_RS03950	COG2205	protein histidine kinase activity
FPL04_RS03955	COG0745	RESPONSE REGULATOR receiver
FPL04_RS03960	COG0277	FAD linked oxidase domain protein
FPL04_RS03965	COG1988	membrane-bound metal-dependent
FPL04_RS03970	COG0792	nuclease activity
FPL04_RS04000	COG0275	rRNA processing
FPL04_RS04005	COG3116	cell division
FPL04_RS04015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FPL04_RS04020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FPL04_RS04025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FPL04_RS04040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPL04_RS04045	COG1181	Belongs to the D-alanine--D-alanine ligase family
FPL04_RS04050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FPL04_RS04075	COG0739	heme binding
FPL04_RS04080	COG0653	protein targeting
FPL04_RS04090	COG0494	nUDIX hydrolase
FPL04_RS04105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FPL04_RS04110	COG3321	synthase
FPL04_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS04110	COG0604	alcohol dehydrogenase
FPL04_RS04120	COG0366	Alpha amylase catalytic
FPL04_RS04155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FPL04_RS04195	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FPL04_RS04210	COG4106	trans-aconitate 2-methyltransferase activity
FPL04_RS04215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPL04_RS04225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FPL04_RS04235	COG0667	Aldo Keto reductase
FPL04_RS04250	COG4771	TonB-dependent receptor
FPL04_RS04270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL04_RS04275	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FPL04_RS04285	COG2175	clavaminate synthase activity
FPL04_RS04295	COG4181	ATPase activity
FPL04_RS04310	COG0642	Histidine kinase
FPL04_RS04320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FPL04_RS04340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FPL04_RS04345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FPL04_RS04355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FPL04_RS04360	COG2967	ApaG domain
FPL04_RS04365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FPL04_RS04370	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FPL04_RS04385	COG0123	including yeast histone deacetylase and acetoin utilization protein
FPL04_RS04390	COG2096	Adenosyltransferase
FPL04_RS04400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL04_RS04405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL04_RS04435	COG3384	dioxygenase
FPL04_RS04440	COG0583	DNA-binding transcription factor activity
FPL04_RS04445	COG0318	PFAM AMP-dependent synthetase and ligase
FPL04_RS04455	COG1024	Enoyl-CoA hydratase
FPL04_RS04505	COG0697	spore germination
FPL04_RS04510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL04_RS04535	COG2197	response regulator
FPL04_RS04545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FPL04_RS04555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FPL04_RS04560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL04_RS04565	COG0583	DNA-binding transcription factor activity
FPL04_RS04570	COG3634	alkyl hydroperoxide reductase activity
FPL04_RS04580	COG2890	protein-(glutamine-N5) methyltransferase activity
FPL04_RS04600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL04_RS04600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL04_RS04630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FPL04_RS04675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FPL04_RS04680	COG1404	Belongs to the peptidase S8 family
FPL04_RS04685	COG1404	Belongs to the peptidase S8 family
FPL04_RS04690	COG1404	Belongs to the peptidase S8 family
FPL04_RS04695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FPL04_RS04715	COG1295	ribonuclease BN
FPL04_RS04720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL04_RS04725	COG1254	Belongs to the acylphosphatase family
FPL04_RS04740	COG0521	Mo-molybdopterin cofactor biosynthetic process
FPL04_RS04750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FPL04_RS04755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FPL04_RS04765	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FPL04_RS04780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FPL04_RS04785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FPL04_RS04790	COG0193	aminoacyl-tRNA hydrolase activity
FPL04_RS04795	COG0012	GTP binding
FPL04_RS04815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FPL04_RS04830	COG0250	Participates in transcription elongation, termination and antitermination
FPL04_RS04835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FPL04_RS04840	COG0081	regulation of translation
FPL04_RS04845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FPL04_RS04850	COG0222	ribosome binding
FPL04_RS04860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FPL04_RS04865	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FPL04_RS04875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FPL04_RS04880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FPL04_RS04885	COG0051	transcription antitermination factor activity, RNA binding
FPL04_RS04905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FPL04_RS04915	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FPL04_RS04930	COG0255	Belongs to the universal ribosomal protein uL29 family
FPL04_RS04945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FPL04_RS04965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FPL04_RS04980	COG1841	ribosomal large subunit assembly
FPL04_RS04990	COG0201	protein transport
FPL04_RS05015	COG0203	ribosomal protein L17
FPL04_RS05025	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FPL04_RS05035	COG0154	amidase activity
FPL04_RS05045	COG1217	gtp-binding protein TYPA
FPL04_RS05050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FPL04_RS05060	COG0625	glutathione transferase activity
FPL04_RS05075	COG0446	pyridine nucleotide-disulphide oxidoreductase
FPL04_RS05075	COG1902	pentaerythritol trinitrate reductase activity
FPL04_RS05080	COG0604	alcohol dehydrogenase
FPL04_RS05090	COG2885	chlorophyll binding
FPL04_RS05115	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FPL04_RS05120	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FPL04_RS05125	COG4208	sulfate ABC transporter
FPL04_RS05130	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FPL04_RS05155	COG0406	alpha-ribazole phosphatase activity
FPL04_RS05165	COG0285	dihydrofolate synthase activity
FPL04_RS05185	COG2833	Protein of unknown function (DUF455)
FPL04_RS05190	COG3291	Pkd domain containing protein
FPL04_RS05200	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL04_RS05205	COG0671	phosphoesterase, PA-phosphatase related
FPL04_RS05210	COG0438	transferase activity, transferring glycosyl groups
FPL04_RS05220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FPL04_RS05235	COG4783	chaperone-mediated protein folding
FPL04_RS05250	COG0473	3-isopropylmalate dehydrogenase activity
FPL04_RS05285	COG0784	Response regulator, receiver
FPL04_RS05285	COG4191	Histidine kinase
FPL04_RS05295	COG0544	peptidyl-prolyl cis-trans isomerase activity
FPL04_RS05305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FPL04_RS05335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL04_RS05345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL04_RS05370	COG0631	protein serine/threonine phosphatase activity
FPL04_RS05385	COG0859	PFAM glycosyl transferase family 9
FPL04_RS05395	COG1234	tRNA 3'-trailer cleavage
FPL04_RS05400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FPL04_RS05405	COG0315	cyclic pyranopterin monophosphate synthase activity
FPL04_RS05410	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FPL04_RS05415	COG0314	molybdopterin synthase activity
FPL04_RS05435	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FPL04_RS05440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FPL04_RS05445	COG0537	adenosine 5'-monophosphoramidase activity
FPL04_RS05465	COG0714	Associated with various cellular activities
FPL04_RS05485	COG0424	maF-like protein
FPL04_RS05490	COG1399	metal-binding, possibly nucleic acid-binding protein
FPL04_RS05495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FPL04_RS05500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL04_RS05510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FPL04_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS05530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FPL04_RS05535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FPL04_RS05570	COG0740	serine-type endopeptidase activity
FPL04_RS05605	COG0582	viral genome integration into host DNA
FPL04_RS05615	COG3829	transcription factor binding
FPL04_RS05655	COG2373	Large extracellular alpha-helical protein
FPL04_RS05685	COG4953	penicillin-binding protein 1C
FPL04_RS05695	COG0678	peroxiredoxin activity
FPL04_RS05715	COG0330	HflC and HflK could
FPL04_RS05720	COG0330	HflC and HflK could
FPL04_RS05740	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FPL04_RS05745	COG0308	aminopeptidase N
FPL04_RS05770	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS05775	COG1309	transcriptional regulator
FPL04_RS05810	COG1111	helicase
FPL04_RS05810	COG1205	dead DEAH box helicase
FPL04_RS05815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FPL04_RS05885	COG1309	transcriptional regulator
FPL04_RS05895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FPL04_RS05910	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS05920	COG3537	Alpha-1,2-mannosidase
FPL04_RS05960	COG2323	membrane
FPL04_RS05975	COG2271	Major facilitator Superfamily
FPL04_RS06000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FPL04_RS06005	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FPL04_RS06010	COG2080	2 iron, 2 sulfur cluster binding
FPL04_RS06055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL04_RS06070	COG0587	DNA-directed DNA polymerase activity
FPL04_RS06090	COG1297	OPT oligopeptide transporter protein
FPL04_RS06110	COG1506	peptidase
FPL04_RS06110	COG0823	Involved in the tonB-independent uptake of proteins
FPL04_RS06125	COG1917	Cupin 2, conserved barrel domain protein
FPL04_RS06125	COG2207	Transcriptional regulator
FPL04_RS06135	COG0753	catalase activity
FPL04_RS06140	COG0656	L-ascorbic acid biosynthetic process
FPL04_RS06145	COG2272	Belongs to the type-B carboxylesterase lipase family
FPL04_RS06150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FPL04_RS06150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FPL04_RS06155	COG2814	Major facilitator Superfamily
FPL04_RS06175	COG2194	sulfuric ester hydrolase activity
FPL04_RS06185	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FPL04_RS06190	COG0745	RESPONSE REGULATOR receiver
FPL04_RS06195	COG5002	protein histidine kinase activity
FPL04_RS06205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FPL04_RS06210	COG2894	cell division
FPL04_RS06215	COG0850	regulation of cytokinetic process
FPL04_RS06230	COG4585	Histidine kinase
FPL04_RS06235	COG2197	response regulator
FPL04_RS06250	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FPL04_RS06285	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FPL04_RS06295	COG1595	DNA-templated transcription, initiation
FPL04_RS06305	COG1946	Acyl-CoA thioesterase
FPL04_RS06310	COG1024	Enoyl-CoA hydratase
FPL04_RS06320	COG0824	Thioesterase
FPL04_RS06325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FPL04_RS06335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FPL04_RS06340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FPL04_RS06355	COG0196	riboflavin kinase activity
FPL04_RS06365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FPL04_RS06370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FPL04_RS06385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FPL04_RS06390	COG1845	cytochrome c oxidase, subunit III
FPL04_RS06395	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FPL04_RS06410	COG3152	Membrane
FPL04_RS06420	COG2207	Transcriptional regulator
FPL04_RS06425	COG0326	Molecular chaperone. Has ATPase activity
FPL04_RS06445	COG1902	pentaerythritol trinitrate reductase activity
FPL04_RS06450	COG1366	Belongs to the anti-sigma-factor antagonist family
FPL04_RS06455	COG1366	Belongs to the anti-sigma-factor antagonist family
FPL04_RS06460	COG2172	sigma factor antagonist activity
FPL04_RS06490	COG4771	TonB-dependent receptor
FPL04_RS06500	COG5507	3-demethylubiquinone-9 3-methyltransferase
FPL04_RS06505	COG2205	protein histidine kinase activity
FPL04_RS06515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FPL04_RS06520	COG3850	Histidine kinase
FPL04_RS06520	COG4999	Histidine kinase
FPL04_RS06520	COG3437	response regulator, receiver
FPL04_RS06520	COG2205	protein histidine kinase activity
FPL04_RS06525	COG0784	Response regulator, receiver
FPL04_RS06525	COG4191	Histidine kinase
FPL04_RS06555	COG3534	alpha-L-arabinofuranosidase
FPL04_RS06570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FPL04_RS06575	COG2070	2-Nitropropane dioxygenase
FPL04_RS06595	COG0336	Belongs to the RNA methyltransferase TrmD family
FPL04_RS06605	COG0534	Mate efflux family protein
FPL04_RS06615	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FPL04_RS06630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FPL04_RS06650	COG3250	beta-galactosidase activity
FPL04_RS06655	COG3867	Arabinogalactan endo-beta-1,4-galactanase
FPL04_RS06665	COG1396	sequence-specific DNA binding
FPL04_RS06665	COG3800	Transcriptional regulator
FPL04_RS06675	COG1960	acyl-CoA dehydrogenase activity
FPL04_RS06720	COG0457	Tetratricopeptide repeat
FPL04_RS06730	COG1024	Enoyl-CoA hydratase
FPL04_RS06730	COG1250	3-hydroxyacyl-CoA dehydrogenase
FPL04_RS06745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FPL04_RS06750	COG0481	GTPase activity
FPL04_RS06765	COG0571	ribonuclease III activity
FPL04_RS06770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FPL04_RS06775	COG1381	Involved in DNA repair and RecF pathway recombination
FPL04_RS06790	COG2954	triphosphatase activity
FPL04_RS06795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FPL04_RS06800	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FPL04_RS06805	COG3046	protein related to deoxyribodipyrimidine photolyase
FPL04_RS06810	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL04_RS06815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FPL04_RS06820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FPL04_RS06825	COG1278	Cold shock
FPL04_RS06830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL04_RS06840	COG1201	RNA secondary structure unwinding
FPL04_RS06845	COG1793	dna ligase
FPL04_RS06855	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FPL04_RS06855	COG1793	dna ligase
FPL04_RS06890	COG0183	Belongs to the thiolase family
FPL04_RS06910	COG1451	nucleotide metabolic process
FPL04_RS06915	COG5487	UPF0391 membrane protein
FPL04_RS06925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FPL04_RS06970	COG1047	Peptidyl-prolyl cis-trans
FPL04_RS06980	COG2824	Alkylphosphonate utilization operon protein PhnA
FPL04_RS07000	COG1902	pentaerythritol trinitrate reductase activity
FPL04_RS07005	COG2814	Major facilitator Superfamily
FPL04_RS07040	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FPL04_RS07040	COG0392	lysyltransferase activity
FPL04_RS07050	COG0251	oxidation-reduction process
FPL04_RS07055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FPL04_RS07070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FPL04_RS07095	COG1595	DNA-templated transcription, initiation
FPL04_RS07110	COG2878	Part of a membrane complex involved in electron transport
FPL04_RS07120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL04_RS07120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL04_RS07135	COG1131	(ABC) transporter
FPL04_RS07140	COG0346	lactoylglutathione lyase activity
FPL04_RS07145	COG0833	amino acid
FPL04_RS07150	COG2040	homocysteine
FPL04_RS07170	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FPL04_RS07190	COG1695	Transcriptional regulator
FPL04_RS07225	COG1981	membrane
FPL04_RS07240	COG0825	malonyl-CoA metabolic process
FPL04_RS07255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL04_RS07260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL04_RS07270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL04_RS07285	COG0750	zinc metalloprotease
FPL04_RS07290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FPL04_RS07295	COG0575	Belongs to the CDS family
FPL04_RS07305	COG0233	cytoplasmic translational termination
FPL04_RS07310	COG0528	UMP kinase activity
FPL04_RS07320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FPL04_RS07325	COG0052	Belongs to the universal ribosomal protein uS2 family
FPL04_RS07380	COG1393	Belongs to the ArsC family
FPL04_RS07385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FPL04_RS07395	COG0367	asparagine synthase
FPL04_RS07405	COG4774	siderophore transport
FPL04_RS07445	COG1566	PFAM secretion protein HlyD family protein
FPL04_RS07450	COG2814	Major facilitator Superfamily
FPL04_RS07460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FPL04_RS07515	COG0339	signal peptide processing
FPL04_RS07525	COG0386	Belongs to the glutathione peroxidase family
FPL04_RS07550	COG0288	reversible hydration of carbon dioxide
FPL04_RS07560	COG2839	Protein conserved in bacteria
FPL04_RS07580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FPL04_RS07585	COG0084	hydrolase, TatD family'
FPL04_RS07600	COG1960	acyl-CoA dehydrogenase activity
FPL04_RS07615	COG0367	asparagine synthase
FPL04_RS07625	COG0305	Participates in initiation and elongation during chromosome replication
FPL04_RS07630	COG0415	Belongs to the DNA photolyase family
FPL04_RS07645	COG0583	DNA-binding transcription factor activity
FPL04_RS07660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_RS07690	COG3706	GGDEF domain
FPL04_RS07710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FPL04_RS07725	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL04_RS07735	COG0497	DNA recombination
FPL04_RS07740	COG1420	regulation of RNA biosynthetic process
FPL04_RS07745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FPL04_RS07750	COG0443	Heat shock 70 kDa protein
FPL04_RS07755	COG0484	heat shock protein binding
FPL04_RS07760	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FPL04_RS07765	COG1605	Chorismate mutase
FPL04_RS07765	COG0287	Prephenate dehydrogenase
FPL04_RS07785	COG2274	protein secretion by the type I secretion system
FPL04_RS07790	COG0583	DNA-binding transcription factor activity
FPL04_RS07795	COG1132	(ABC) transporter
FPL04_RS07830	COG2850	peptidyl-arginine hydroxylation
FPL04_RS07845	COG1253	flavin adenine dinucleotide binding
FPL04_RS07875	COG1131	(ABC) transporter
FPL04_RS07880	COG1725	Transcriptional regulator
FPL04_RS07890	COG0386	Belongs to the glutathione peroxidase family
FPL04_RS07905	COG2900	Belongs to the SlyX family
FPL04_RS07935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPL04_RS07945	COG1410	methionine synthase
FPL04_RS07945	COG0646	methionine synthase
FPL04_RS07950	COG0646	methionine synthase
FPL04_RS07950	COG1410	methionine synthase
FPL04_RS07955	COG2226	methyltransferase
FPL04_RS07960	COG1960	acyl-CoA dehydrogenase activity
FPL04_RS07980	COG0557	exoribonuclease II activity
FPL04_RS07990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPL04_RS08005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FPL04_RS08015	COG0704	Plays a role in the regulation of phosphate uptake
FPL04_RS08020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FPL04_RS08025	COG0581	inorganic phosphate transmembrane transporter activity
FPL04_RS08030	COG0573	inorganic phosphate transmembrane transporter activity
FPL04_RS08035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FPL04_RS08060	COG0659	secondary active sulfate transmembrane transporter activity
FPL04_RS08065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FPL04_RS08075	COG1024	Enoyl-CoA hydratase
FPL04_RS08085	COG0494	nUDIX hydrolase
FPL04_RS08120	COG0488	(ABC) transporter
FPL04_RS08135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FPL04_RS08145	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FPL04_RS08160	COG2925	Exonuclease
FPL04_RS08165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL04_RS08170	COG3844	kynureninase activity
FPL04_RS08180	COG0662	Cupin 2, conserved barrel domain protein
FPL04_RS08185	COG0288	reversible hydration of carbon dioxide
FPL04_RS08210	COG0017	Asparaginyl-tRNA synthetase
FPL04_RS08220	COG0316	Belongs to the HesB IscA family
FPL04_RS08245	COG3115	cell septum assembly
FPL04_RS08255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL04_RS08260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FPL04_RS08265	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FPL04_RS08280	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FPL04_RS08290	COG4993	Dehydrogenase
FPL04_RS08305	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FPL04_RS08315	COG2986	histidine ammonia-lyase
FPL04_RS08320	COG1228	amidohydrolase
FPL04_RS08355	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FPL04_RS08360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FPL04_RS08365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FPL04_RS08370	COG0077	Prephenate dehydratase
FPL04_RS08370	COG1605	Chorismate mutase
FPL04_RS08375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FPL04_RS08390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FPL04_RS08395	COG0583	DNA-binding transcription factor activity
FPL04_RS08415	COG0840	transmembrane signaling receptor activity
FPL04_RS08450	COG0840	transmembrane signaling receptor activity
FPL04_RS08470	COG0784	Response regulator, receiver
FPL04_RS08470	COG4191	Histidine kinase
FPL04_RS08475	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FPL04_RS08480	COG0784	Response regulator, receiver
FPL04_RS08480	COG4191	Histidine kinase
FPL04_RS08495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL04_RS08515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FPL04_RS08520	COG1404	Belongs to the peptidase S8 family
FPL04_RS08530	COG1595	DNA-templated transcription, initiation
FPL04_RS08580	COG2244	polysaccharide biosynthetic process
FPL04_RS08610	COG2264	protein methyltransferase activity
FPL04_RS08615	COG0438	transferase activity, transferring glycosyl groups
FPL04_RS08620	COG0438	transferase activity, transferring glycosyl groups
FPL04_RS08635	COG1136	(ABC) transporter
FPL04_RS08640	COG1132	(ABC) transporter
FPL04_RS08645	COG0477	Major facilitator Superfamily
FPL04_RS08650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL04_RS08665	COG1253	flavin adenine dinucleotide binding
FPL04_RS08720	COG0148	phosphopyruvate hydratase activity
FPL04_RS08730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FPL04_RS08745	COG2840	Smr protein MutS2
FPL04_RS08750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FPL04_RS08755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FPL04_RS08760	COG1238	metal cluster binding
FPL04_RS08775	COG1534	Rna-binding protein
FPL04_RS08780	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FPL04_RS08790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FPL04_RS08805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FPL04_RS08810	COG1546	Belongs to the CinA family
FPL04_RS08820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPL04_RS08825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL04_RS08830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FPL04_RS08835	COG2137	regulation of response to DNA damage stimulus
FPL04_RS08840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FPL04_RS08845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FPL04_RS09030	COG3179	chitinase
FPL04_RS09120	COG1196	nuclear chromosome segregation
FPL04_RS09195	COG2944	sequence-specific DNA binding
FPL04_RS09215	COG0582	viral genome integration into host DNA
FPL04_RS09225	COG1741	Belongs to the pirin family
FPL04_RS09230	COG0583	DNA-binding transcription factor activity
FPL04_RS09255	COG0352	thiamine-phosphate diphosphorylase activity
FPL04_RS09255	COG0351	phosphomethylpyrimidine kinase
FPL04_RS09270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FPL04_RS09275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FPL04_RS09290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPL04_RS09300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FPL04_RS09305	COG3734	2-keto-3-deoxy-galactonokinase
FPL04_RS09315	COG4948	Mandelate Racemase Muconate Lactonizing
FPL04_RS09320	COG0800	Aldolase
FPL04_RS09360	COG1501	Belongs to the glycosyl hydrolase 31 family
FPL04_RS09370	COG1070	Carbohydrate kinase
FPL04_RS09375	COG2115	Belongs to the xylose isomerase family
FPL04_RS09380	COG0477	Major facilitator Superfamily
FPL04_RS09400	COG0860	N-Acetylmuramoyl-L-alanine amidase
FPL04_RS09425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FPL04_RS09430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FPL04_RS09465	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL04_RS09480	COG2203	Gaf domain
FPL04_RS09480	COG3706	GGDEF domain
FPL04_RS09480	COG5001	Diguanylate cyclase
FPL04_RS09480	COG4251	negative regulation of phosphorylation
FPL04_RS09485	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL04_RS09495	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FPL04_RS09505	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FPL04_RS09510	COG0671	phosphoesterase, PA-phosphatase related
FPL04_RS09520	COG1794	racemase activity, acting on amino acids and derivatives
FPL04_RS09530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FPL04_RS09550	COG1012	belongs to the aldehyde dehydrogenase family
FPL04_RS09570	COG1215	transferase activity, transferring glycosyl groups
FPL04_RS09575	COG0726	polysaccharide deacetylase
FPL04_RS09575	COG1649	PFAM Uncharacterised BCR, COG1649
FPL04_RS09655	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FPL04_RS09685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL04_RS09690	COG0124	histidyl-tRNA synthetase
FPL04_RS09705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FPL04_RS09710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL04_RS09715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FPL04_RS09715	COG0131	Imidazoleglycerol-phosphate dehydratase
FPL04_RS09720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FPL04_RS09725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FPL04_RS09730	COG0107	imidazoleglycerol-phosphate synthase activity
FPL04_RS09735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FPL04_RS09735	COG0140	phosphoribosyl-ATP diphosphatase activity
FPL04_RS09750	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FPL04_RS09770	COG0531	amino acid
FPL04_RS09775	COG0531	amino acid
FPL04_RS09790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FPL04_RS09795	COG0277	FAD linked oxidase domain protein
FPL04_RS09815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FPL04_RS09855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL04_RS09860	COG2258	MOSC domain
FPL04_RS09870	COG0505	Belongs to the CarA family
FPL04_RS09880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FPL04_RS09885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL04_RS09895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FPL04_RS09915	COG3279	Response regulator of the LytR AlgR family
FPL04_RS09925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FPL04_RS09935	COG2198	Histidine kinase
FPL04_RS09935	COG2205	protein histidine kinase activity
FPL04_RS09935	COG0784	Response regulator, receiver
FPL04_RS09940	COG1024	Enoyl-CoA hydratase
FPL04_RS09945	COG0318	PFAM AMP-dependent synthetase and ligase
FPL04_RS09975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL04_RS10000	COG0840	transmembrane signaling receptor activity
FPL04_RS10010	COG0835	chemotaxis
FPL04_RS10030	COG0840	transmembrane signaling receptor activity
FPL04_RS10035	COG0840	transmembrane signaling receptor activity
FPL04_RS10040	COG0840	transmembrane signaling receptor activity
FPL04_RS10045	COG0840	transmembrane signaling receptor activity
FPL04_RS10050	COG0840	transmembrane signaling receptor activity
FPL04_RS10070	COG0840	transmembrane signaling receptor activity
FPL04_RS10090	COG0745	RESPONSE REGULATOR receiver
FPL04_RS10100	COG0835	chemotaxis
FPL04_RS10110	COG1360	Flagellar Motor Protein
FPL04_RS10115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FPL04_RS10185	COG0784	Response regulator, receiver
FPL04_RS10185	COG0643	Histidine kinase
FPL04_RS10185	COG2198	Histidine kinase
FPL04_RS10240	COG5001	Diguanylate cyclase
FPL04_RS10240	COG3300	MHYT domain
FPL04_RS10245	COG1684	flagellar biosynthetic protein fliR
FPL04_RS10260	COG3190	flagellar
FPL04_RS10310	COG1677	Flagellar hook-basal body complex protein FliE
FPL04_RS10365	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS10375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL04_RS10395	COG2201	protein-glutamate methylesterase activity
FPL04_RS10425	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FPL04_RS10430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FPL04_RS10445	COG3951	Flagellar rod assembly protein muramidase FlgJ
FPL04_RS10445	COG1705	Flagellar rod assembly protein muramidase FlgJ
FPL04_RS10450	COG1706	bacterial-type flagellum-dependent cell motility
FPL04_RS10455	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FPL04_RS10470	COG4787	bacterial-type flagellum-dependent cell motility
FPL04_RS10480	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FPL04_RS10485	COG1558	bacterial-type flagellum-dependent cell motility
FPL04_RS10490	COG1815	bacterial-type flagellum-dependent cell motility
FPL04_RS10495	COG0784	Response regulator, receiver
FPL04_RS10495	COG0835	chemotaxis
FPL04_RS10515	COG4191	Histidine kinase
FPL04_RS10550	COG0482	sulfurtransferase activity
FPL04_RS10565	COG0542	response to heat
FPL04_RS10575	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FPL04_RS10585	COG0492	ferredoxin-NADP+ reductase activity
FPL04_RS10590	COG1674	ftsk spoiiie
FPL04_RS10605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FPL04_RS10610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FPL04_RS10615	COG0183	Belongs to the thiolase family
FPL04_RS10620	COG1024	Enoyl-CoA hydratase
FPL04_RS10620	COG1250	3-hydroxyacyl-CoA dehydrogenase
FPL04_RS10635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FPL04_RS10645	COG1426	Protein conserved in bacteria
FPL04_RS10655	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL04_RS10660	COG1160	GTP binding
FPL04_RS10665	COG0303	'Molybdopterin
FPL04_RS10670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FPL04_RS10695	COG0708	Exodeoxyribonuclease III
FPL04_RS10705	COG0303	'Molybdopterin
FPL04_RS10710	COG0746	molybdenum cofactor guanylyltransferase activity
FPL04_RS10720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FPL04_RS10720	COG1648	precorrin-2 dehydrogenase activity
FPL04_RS10730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FPL04_RS10735	COG2223	nitrite transmembrane transporter activity
FPL04_RS10740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FPL04_RS10750	COG0243	molybdopterin cofactor binding
FPL04_RS10775	COG5001	Diguanylate cyclase
FPL04_RS10820	COG0784	Response regulator, receiver
FPL04_RS10820	COG4191	Histidine kinase
FPL04_RS10870	COG0840	transmembrane signaling receptor activity
FPL04_RS10900	COG3781	membrane
FPL04_RS10910	COG2197	response regulator
FPL04_RS10925	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS11025	COG0859	PFAM glycosyl transferase family 9
FPL04_RS11050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_RS11070	COG4106	trans-aconitate 2-methyltransferase activity
FPL04_RS11080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_RS11080	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FPL04_RS11115	COG2192	nodulation
FPL04_RS11125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_RS11145	COG0367	asparagine synthase
FPL04_RS11155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_RS11160	COG1136	(ABC) transporter
FPL04_RS11160	COG0577	efflux transmembrane transporter activity
FPL04_RS11165	COG1136	(ABC) transporter
FPL04_RS11165	COG0577	efflux transmembrane transporter activity
FPL04_RS11170	COG0577	efflux transmembrane transporter activity
FPL04_RS11170	COG1136	(ABC) transporter
FPL04_RS11175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPL04_RS11175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL04_RS11175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_RS11175	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS11175	COG3321	synthase
FPL04_RS11190	COG0300	oxidoreductase activity
FPL04_RS11190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS11190	COG3321	synthase
FPL04_RS11190	COG0318	PFAM AMP-dependent synthetase and ligase
FPL04_RS11225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FPL04_RS11250	COG3459	Glycosyltransferase 36 associated
FPL04_RS11500	COG0428	transporter
FPL04_RS11515	COG1530	ribonuclease E activity
FPL04_RS11525	COG1054	Belongs to the UPF0176 family
FPL04_RS11545	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FPL04_RS11570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FPL04_RS11575	COG0322	excinuclease ABC activity
FPL04_RS11585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FPL04_RS11590	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FPL04_RS11595	COG1663	tetraacyldisaccharide 4'-kinase activity
FPL04_RS11600	COG1132	(ABC) transporter
FPL04_RS11610	COG0811	peptide transport
FPL04_RS11625	COG1136	(ABC) transporter
FPL04_RS11630	COG4591	ABC-type transport system involved in lipoprotein release permease component
FPL04_RS11640	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FPL04_RS11645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FPL04_RS11660	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FPL04_RS11665	COG2009	succinate dehydrogenase
FPL04_RS11685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FPL04_RS11690	COG0837	glucose binding
FPL04_RS11700	COG0129	dihydroxy-acid dehydratase activity
FPL04_RS11705	COG0800	Aldolase
FPL04_RS11770	COG0784	Response regulator, receiver
FPL04_RS11770	COG2205	protein histidine kinase activity
FPL04_RS11770	COG5002	protein histidine kinase activity
FPL04_RS11775	COG2183	response to ionizing radiation
FPL04_RS11785	COG0723	plastoquinol--plastocyanin reductase activity
FPL04_RS11785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL04_RS11800	COG3243	poly(R)-hydroxyalkanoic acid synthase
FPL04_RS11810	COG1183	phosphatidylcholine synthase activity
FPL04_RS11815	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS11840	COG0668	transmembrane transport
FPL04_RS11845	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FPL04_RS11860	COG1914	H( )-stimulated, divalent metal cation uptake system
FPL04_RS11870	COG2814	Major facilitator Superfamily
FPL04_RS11885	COG1335	isochorismatase
FPL04_RS11900	COG2197	response regulator
FPL04_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS11935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FPL04_RS11945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPL04_RS11945	COG0475	glutathione-regulated potassium exporter activity
FPL04_RS11950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FPL04_RS11960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FPL04_RS11965	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FPL04_RS11980	COG0539	negative regulation of cytoplasmic translation
FPL04_RS12000	COG2957	Belongs to the agmatine deiminase family
FPL04_RS12005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPL04_RS12030	COG0395	ABC-type sugar transport system, permease component
FPL04_RS12035	COG1175	transmembrane transport
FPL04_RS12040	COG1653	transport
FPL04_RS12065	COG2350	Protein conserved in bacteria
FPL04_RS12070	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FPL04_RS12075	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FPL04_RS12080	COG1187	pseudouridine synthase activity
FPL04_RS12100	COG0436	Aminotransferase
FPL04_RS12105	COG4133	protoheme IX ABC transporter activity
FPL04_RS12125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FPL04_RS12150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL04_RS12160	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FPL04_RS12165	COG4988	ABC transporter
FPL04_RS12175	COG1294	oxidase, subunit
FPL04_RS12220	COG0165	Argininosuccinate lyase
FPL04_RS12235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FPL04_RS12240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FPL04_RS12245	COG0137	argininosuccinate synthase activity
FPL04_RS12250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FPL04_RS12265	COG0215	cysteine-tRNA ligase activity
FPL04_RS12275	COG2166	iron-sulfur cluster assembly
FPL04_RS12295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FPL04_RS12310	COG4303	Ethanolamine ammonia lyase large subunit
FPL04_RS12315	COG4302	ethanolamine ammonia-lyase activity
FPL04_RS12330	COG4677	pectinesterase activity
FPL04_RS12350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FPL04_RS12355	COG0402	S-adenosylhomocysteine deaminase activity
FPL04_RS12365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FPL04_RS12375	COG3300	MHYT domain
FPL04_RS12375	COG5001	Diguanylate cyclase
FPL04_RS12390	COG0483	inositol monophosphate 1-phosphatase activity
FPL04_RS12395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FPL04_RS12410	COG0488	(ABC) transporter
FPL04_RS12415	COG0513	Belongs to the DEAD box helicase family
FPL04_RS12420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FPL04_RS12425	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FPL04_RS12435	COG0625	glutathione transferase activity
FPL04_RS12450	COG4681	YaeQ
FPL04_RS12455	COG2081	HI0933 family
FPL04_RS12470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL04_RS12475	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS12495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FPL04_RS12500	COG0860	N-Acetylmuramoyl-L-alanine amidase
FPL04_RS12510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FPL04_RS12510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FPL04_RS12515	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FPL04_RS12530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FPL04_RS12560	COG0835	chemotaxis
FPL04_RS12565	COG0840	transmembrane signaling receptor activity
FPL04_RS12570	COG2094	Belongs to the DNA glycosylase MPG family
FPL04_RS12575	COG1201	RNA secondary structure unwinding
FPL04_RS12585	COG2969	positive regulation of protein catabolic process
FPL04_RS12590	COG0625	glutathione transferase activity
FPL04_RS12595	COG2857	Cytochrome c1
FPL04_RS12600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FPL04_RS12605	COG0723	plastoquinol--plastocyanin reductase activity
FPL04_RS12610	COG0741	lytic transglycosylase activity
FPL04_RS12625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FPL04_RS12630	COG1702	phosphate starvation-inducible protein PhoH
FPL04_RS12650	COG4535	Mg2 and Co2 transporter CorC
FPL04_RS12665	COG1012	belongs to the aldehyde dehydrogenase family
FPL04_RS12675	COG1177	transmembrane transport
FPL04_RS12680	COG1176	ABC-type spermidine putrescine transport system, permease component I
FPL04_RS12685	COG3842	ATPase activity
FPL04_RS12705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FPL04_RS12720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FPL04_RS12725	COG0174	glutamine synthetase
FPL04_RS12730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL04_RS12740	COG2703	oxygen carrier activity
FPL04_RS12745	COG0477	Major facilitator Superfamily
FPL04_RS12755	COG0784	Response regulator, receiver
FPL04_RS12755	COG2205	protein histidine kinase activity
FPL04_RS12755	COG5002	protein histidine kinase activity
FPL04_RS12765	COG0243	molybdopterin cofactor binding
FPL04_RS12775	COG2223	nitrite transmembrane transporter activity
FPL04_RS12780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FPL04_RS12790	COG2733	membrane
FPL04_RS12795	COG0784	Response regulator, receiver
FPL04_RS12795	COG2205	protein histidine kinase activity
FPL04_RS12795	COG5002	protein histidine kinase activity
FPL04_RS12805	COG0477	Major facilitator Superfamily
FPL04_RS12820	COG0300	oxidoreductase activity
FPL04_RS12830	COG1902	pentaerythritol trinitrate reductase activity
FPL04_RS12840	COG3321	synthase
FPL04_RS12840	COG0604	alcohol dehydrogenase
FPL04_RS12850	COG2902	Dehydrogenase
FPL04_RS12860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_RS12865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL04_RS12875	COG1609	Transcriptional regulator
FPL04_RS12880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FPL04_RS12880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL04_RS12885	COG1105	Belongs to the carbohydrate kinase PfkB family
FPL04_RS12890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FPL04_RS12890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FPL04_RS12900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FPL04_RS12910	COG1862	Preprotein translocase
FPL04_RS12965	COG3291	Pkd domain containing protein
FPL04_RS12975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FPL04_RS12995	COG0742	ribosomal rna small subunit methyltransferase
FPL04_RS13000	COG0326	Molecular chaperone. Has ATPase activity
FPL04_RS13045	COG0531	amino acid
FPL04_RS13060	COG0006	proline dipeptidase activity
FPL04_RS13070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPL04_RS13085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL04_RS13090	COG3938	Belongs to the proline racemase family
FPL04_RS13100	COG0552	protein localization to endoplasmic reticulum
FPL04_RS13120	COG4191	Histidine kinase
FPL04_RS13120	COG0784	Response regulator, receiver
FPL04_RS13130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FPL04_RS13155	COG1960	acyl-CoA dehydrogenase activity
FPL04_RS13165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FPL04_RS13190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL04_RS13195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL04_RS13220	COG0438	transferase activity, transferring glycosyl groups
FPL04_RS13230	COG0438	transferase activity, transferring glycosyl groups
FPL04_RS13235	COG0438	transferase activity, transferring glycosyl groups
FPL04_RS13285	COG0072	phenylalanine-tRNA ligase activity
FPL04_RS13285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL04_RS13290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FPL04_RS13305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FPL04_RS13310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FPL04_RS13325	COG2211	Major facilitator Superfamily
FPL04_RS13335	COG1082	Xylose isomerase domain protein TIM barrel
FPL04_RS13350	COG0366	Alpha amylase catalytic
FPL04_RS13395	COG3702	type iv secretory pathway
FPL04_RS13415	COG2948	multi-organism process
FPL04_RS13435	COG3505	Type IV secretory pathway VirD4
FPL04_RS13450	COG0556	nucleotide-excision repair
FPL04_RS13495	COG3275	phosphorelay sensor kinase activity
FPL04_RS13500	COG1611	Belongs to the LOG family
FPL04_RS13510	COG2095	MarC family integral membrane protein
FPL04_RS13515	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS13520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FPL04_RS13555	COG1185	polyribonucleotide nucleotidyltransferase activity
FPL04_RS13560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FPL04_RS13565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FPL04_RS13570	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FPL04_RS13580	COG0195	Participates in both transcription termination and antitermination
FPL04_RS13585	COG0779	Required for maturation of 30S ribosomal subunits
FPL04_RS13595	COG1007	ATP synthesis coupled electron transport
FPL04_RS13615	COG0839	Belongs to the complex I subunit 6 family
FPL04_RS13620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL04_RS13625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FPL04_RS13630	COG1034	ATP synthesis coupled electron transport
FPL04_RS13635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FPL04_RS13640	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FPL04_RS13650	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL04_RS13660	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL04_RS13680	COG4221	oxidoreductase activity
FPL04_RS13710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FPL04_RS13715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FPL04_RS13730	COG0133	tryptophan synthase activity
FPL04_RS13745	COG0101	tRNA pseudouridine synthase activity
FPL04_RS13760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FPL04_RS13765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FPL04_RS13780	COG2890	protein-(glutamine-N5) methyltransferase activity
FPL04_RS13790	COG0688	phosphatidylethanolamine metabolic process
FPL04_RS13805	COG0433	COG0433 Predicted ATPase
FPL04_RS13810	COG0494	nUDIX hydrolase
FPL04_RS13830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL04_RS13860	COG0717	Belongs to the dCTP deaminase family
FPL04_RS13870	COG0489	protein tyrosine kinase activity
FPL04_RS13890	COG3590	peptidase
FPL04_RS13915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL04_RS13920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL04_RS13925	COG2311	Membrane
FPL04_RS13930	COG1047	Peptidyl-prolyl cis-trans
FPL04_RS13935	COG0791	NLP P60 protein
FPL04_RS13940	COG0791	NLP P60 protein
FPL04_RS13955	COG1301	dicarboxylic acid transport
FPL04_RS13960	COG1785	Belongs to the alkaline phosphatase family
FPL04_RS13965	COG0037	tRNA processing
FPL04_RS13970	COG1722	exodeoxyribonuclease VII activity
FPL04_RS13975	COG0142	geranyltranstransferase activity
FPL04_RS13980	COG4104	PAAR repeat-containing protein
FPL04_RS13990	COG0312	modulator of DNA gyrase
FPL04_RS14000	COG0312	modulator of DNA gyrase
FPL04_RS14010	COG3164	Protein of unknown function
FPL04_RS14020	COG0424	maF-like protein
FPL04_RS14025	COG2968	Membrane
FPL04_RS14060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FPL04_RS14075	COG0495	leucyl-tRNA aminoacylation
FPL04_RS14085	COG3118	belongs to the thioredoxin family
FPL04_RS14095	COG2155	Conserved Protein
FPL04_RS14145	COG1132	(ABC) transporter
FPL04_RS14175	COG0745	RESPONSE REGULATOR receiver
FPL04_RS14180	COG5000	phosphorelay sensor kinase activity
FPL04_RS14180	COG5002	protein histidine kinase activity
FPL04_RS14185	COG0475	glutathione-regulated potassium exporter activity
FPL04_RS14195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FPL04_RS14215	COG1187	pseudouridine synthase activity
FPL04_RS14220	COG5001	Diguanylate cyclase
FPL04_RS14220	COG5002	protein histidine kinase activity
FPL04_RS14335	COG0667	Aldo Keto reductase
FPL04_RS14340	COG2814	Major facilitator Superfamily
FPL04_RS14345	COG0583	DNA-binding transcription factor activity
FPL04_RS14365	COG2207	Transcriptional regulator
FPL04_RS14380	COG1309	transcriptional regulator
FPL04_RS14390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL04_RS14405	COG0430	RNA-3'-phosphate cyclase activity
FPL04_RS14410	COG1690	Belongs to the RtcB family
FPL04_RS14420	COG4650	regulator
FPL04_RS14425	COG0735	belongs to the Fur family
FPL04_RS14430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL04_RS14455	COG4452	Inner membrane protein CreD
FPL04_RS14465	COG2205	protein histidine kinase activity
FPL04_RS14470	COG0745	RESPONSE REGULATOR receiver
FPL04_RS14475	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FPL04_RS14490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FPL04_RS14500	COG2198	Histidine kinase
FPL04_RS14500	COG0643	Histidine kinase
FPL04_RS14510	COG0840	transmembrane signaling receptor activity
FPL04_RS14515	COG0835	chemotaxis
FPL04_RS14520	COG2199	diguanylate cyclase activity
FPL04_RS14520	COG2200	EAL domain
FPL04_RS14520	COG2202	Pas domain
FPL04_RS14525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FPL04_RS14535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL04_RS14540	COG3590	peptidase
FPL04_RS14550	COG0588	phosphoglycerate mutase activity
FPL04_RS14555	COG1515	deoxyribonuclease V activity
FPL04_RS14560	COG1741	Belongs to the pirin family
FPL04_RS14575	COG1741	Belongs to the pirin family
FPL04_RS14580	COG1966	Carbon starvation protein
FPL04_RS14585	COG2879	small protein
FPL04_RS14595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FPL04_RS14630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FPL04_RS14635	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FPL04_RS14640	COG2080	2 iron, 2 sulfur cluster binding
FPL04_RS14645	COG0604	alcohol dehydrogenase
FPL04_RS14645	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS14645	COG3321	synthase
FPL04_RS14650	COG3706	GGDEF domain
FPL04_RS14650	COG4251	negative regulation of phosphorylation
FPL04_RS14650	COG5001	Diguanylate cyclase
FPL04_RS14650	COG2203	Gaf domain
FPL04_RS14655	COG0629	single-stranded DNA binding
FPL04_RS14660	COG0142	geranyltranstransferase activity
FPL04_RS14670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FPL04_RS14685	COG0527	aspartate kinase activity
FPL04_RS14690	COG0384	phenazine biosynthesis protein PhzF
FPL04_RS14695	COG0384	phenazine biosynthesis protein PhzF
FPL04_RS14705	COG1764	response to oxidative stress
FPL04_RS14715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FPL04_RS14720	COG1678	Uncharacterized ACR, COG1678
FPL04_RS14725	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FPL04_RS14730	COG0519	Catalyzes the synthesis of GMP from XMP
FPL04_RS14750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FPL04_RS14765	COG4942	peptidase
FPL04_RS14785	COG0693	protein deglycase activity
FPL04_RS14795	COG1959	2 iron, 2 sulfur cluster binding
FPL04_RS14800	COG0719	Fe-S assembly protein
FPL04_RS14805	COG0396	ATPase activity
FPL04_RS14810	COG0719	Fe-S assembly protein
FPL04_RS14815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FPL04_RS14820	COG0456	acetyltransferase
FPL04_RS14825	COG2146	nitrite reductase [NAD(P)H] activity
FPL04_RS14830	COG4774	siderophore transport
FPL04_RS14835	COG3128	pkhd-type hydroxylase
FPL04_RS14860	COG1477	protein flavinylation
FPL04_RS14880	COG1555	photosystem II stabilization
FPL04_RS14885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FPL04_RS14900	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FPL04_RS14915	COG0628	permease
FPL04_RS14935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FPL04_RS14960	COG0271	Belongs to the BolA IbaG family
FPL04_RS14970	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FPL04_RS14980	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FPL04_RS14985	COG1137	ATPase activity
FPL04_RS15000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL04_RS15020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL04_RS15025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FPL04_RS15030	COG2239	Acts as a magnesium transporter
FPL04_RS15040	COG1294	oxidase, subunit
FPL04_RS15045	COG1271	oxidase subunit
FPL04_RS15060	COG1113	amino acid transport
FPL04_RS15075	COG2197	response regulator
FPL04_RS15080	COG0531	amino acid
FPL04_RS15135	COG2814	Major facilitator Superfamily
FPL04_RS15140	COG0754	glutathionylspermidine amidase activity
FPL04_RS15165	COG1842	Phage shock protein A
FPL04_RS15185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FPL04_RS15190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FPL04_RS15200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FPL04_RS15275	COG0477	Major facilitator Superfamily
FPL04_RS15290	COG2353	YceI-like domain
FPL04_RS15295	COG3038	cytochrome b561
FPL04_RS15305	COG1278	Cold shock
FPL04_RS15320	COG1760	l-serine dehydratase
FPL04_RS15330	COG0460	homoserine dehydrogenase
FPL04_RS15330	COG0527	aspartate kinase activity
FPL04_RS15335	COG0626	cystathionine gamma-synthase activity
FPL04_RS15340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL04_RS15345	COG0739	heme binding
FPL04_RS15350	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FPL04_RS15355	COG1272	protein, Hemolysin III
FPL04_RS15360	COG2982	Protein involved in outer membrane biogenesis
FPL04_RS15375	COG0463	Glycosyl transferase, family 2
FPL04_RS15380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FPL04_RS15385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FPL04_RS15400	COG1309	transcriptional regulator
FPL04_RS15410	COG1960	acyl-CoA dehydrogenase activity
FPL04_RS15445	COG0509	glycine decarboxylation via glycine cleavage system
FPL04_RS15450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FPL04_RS15460	COG0330	HflC and HflK could
FPL04_RS15465	COG1742	UPF0060 membrane protein
FPL04_RS15470	COG3956	TIGRFAM MazG family protein
FPL04_RS15480	COG0494	nUDIX hydrolase
FPL04_RS15490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FPL04_RS15495	COG0837	glucose binding
FPL04_RS15510	COG1388	LysM domain
FPL04_RS15510	COG3858	chitin binding
FPL04_RS15515	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FPL04_RS15520	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL04_RS15530	COG3537	Alpha-1,2-mannosidase
FPL04_RS15570	COG1446	asparaginase
FPL04_RS15575	COG2304	oxidoreductase activity
FPL04_RS15580	COG1595	DNA-templated transcription, initiation
FPL04_RS15605	COG0643	Histidine kinase
FPL04_RS15605	COG0784	Response regulator, receiver
FPL04_RS15605	COG2198	Histidine kinase
FPL04_RS15610	COG0840	transmembrane signaling receptor activity
FPL04_RS15615	COG0835	chemotaxis
FPL04_RS15630	COG0189	ligase activity
FPL04_RS15640	COG1397	ADP-ribosylglycohydrolase
FPL04_RS15650	COG1199	ATP-dependent helicase activity
FPL04_RS15660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FPL04_RS15665	COG1215	transferase activity, transferring glycosyl groups
FPL04_RS15680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPL04_RS15690	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FPL04_RS15695	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FPL04_RS15705	COG0535	radical SAM domain protein
FPL04_RS15720	COG0837	glucose binding
FPL04_RS15730	COG1643	Atp-dependent helicase
FPL04_RS15735	COG0783	Belongs to the Dps family
FPL04_RS15745	COG0514	ATP-dependent DNA helicase (RecQ)
FPL04_RS15765	COG1187	pseudouridine synthase activity
FPL04_RS15775	COG0840	transmembrane signaling receptor activity
FPL04_RS15800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FPL04_RS15820	COG0667	Aldo Keto reductase
FPL04_RS15825	COG0602	queuosine metabolic process
FPL04_RS15835	COG2885	chlorophyll binding
FPL04_RS15840	COG0823	Involved in the tonB-independent uptake of proteins
FPL04_RS15850	COG0848	biopolymer transport protein
FPL04_RS15860	COG0824	Thioesterase
FPL04_RS15865	COG2255	four-way junction helicase activity
FPL04_RS15920	COG0477	Major facilitator Superfamily
FPL04_RS15960	COG0488	(ABC) transporter
FPL04_RS15995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPL04_RS15995	COG4651	solute:proton antiporter activity
FPL04_RS16005	COG4772	TonB-dependent receptor
FPL04_RS16015	COG4264	IucA IucC family
FPL04_RS16020	COG2814	Major facilitator Superfamily
FPL04_RS16025	COG4264	IucA IucC family
FPL04_RS16030	COG0019	diaminopimelate decarboxylase activity
FPL04_RS16055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FPL04_RS16065	COG4206	TonB-dependent receptor
FPL04_RS16085	COG0542	response to heat
FPL04_RS16090	COG1116	anion transmembrane transporter activity
FPL04_RS16095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL04_RS16100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FPL04_RS16105	COG0667	Aldo Keto reductase
FPL04_RS16110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL04_RS16115	COG4771	TonB-dependent receptor
FPL04_RS16160	COG1877	trehalose-phosphatase activity
FPL04_RS16165	COG3387	PFAM Glycoside hydrolase 15-related
FPL04_RS16185	COG0840	transmembrane signaling receptor activity
FPL04_RS16195	COG3011	Protein conserved in bacteria
FPL04_RS16205	COG1496	oxidoreductase activity
FPL04_RS16210	COG0564	pseudouridine synthase activity
FPL04_RS16215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL04_RS16225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FPL04_RS16225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPL04_RS16250	COG0045	succinate-CoA ligase (ADP-forming) activity
FPL04_RS16285	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FPL04_RS16305	COG0745	RESPONSE REGULATOR receiver
FPL04_RS16315	COG0189	ligase activity
FPL04_RS16370	COG4974	Belongs to the 'phage' integrase family
FPL04_RS16395	COG0583	DNA-binding transcription factor activity
FPL04_RS16425	COG2003	Belongs to the UPF0758 family
FPL04_RS16495	COG3209	COG3209 Rhs family protein
FPL04_RS16550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FPL04_RS16555	COG0471	metal ion transport
FPL04_RS16555	COG3273	potassium ion transport
FPL04_RS16575	COG1970	mechanosensitive ion channel activity
FPL04_RS16585	COG1609	Transcriptional regulator
FPL04_RS16595	COG3250	beta-galactosidase activity
FPL04_RS16600	COG4948	Mandelate Racemase Muconate Lactonizing
FPL04_RS16605	COG2272	Belongs to the type-B carboxylesterase lipase family
FPL04_RS16610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPL04_RS16625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL04_RS16630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_RS16635	COG0529	Catalyzes the synthesis of activated sulfate
FPL04_RS16635	COG2895	sulfate adenylyltransferase (ATP) activity
FPL04_RS16645	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FPL04_RS16650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FPL04_RS16655	COG0175	sulfate reduction
FPL04_RS16675	COG2198	Histidine kinase
FPL04_RS16675	COG0784	Response regulator, receiver
FPL04_RS16675	COG2205	protein histidine kinase activity
FPL04_RS16690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FPL04_RS16690	COG1648	precorrin-2 dehydrogenase activity
FPL04_RS16705	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FPL04_RS16710	COG3588	fructose-bisphosphate aldolase
FPL04_RS16715	COG0469	pyruvate kinase activity
FPL04_RS16755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FPL04_RS16770	COG3047	cAMP biosynthetic process
FPL04_RS16780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL04_RS16780	COG3453	Protein conserved in bacteria
FPL04_RS16785	COG0725	ABC transporter, periplasmic molybdate-binding protein
FPL04_RS16790	COG4149	molybdate abc transporter
FPL04_RS16825	COG0642	Histidine kinase
FPL04_RS16840	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS16850	COG1022	Amp-dependent synthetase and ligase
FPL04_RS16875	COG1376	ErfK ybiS ycfS ynhG family protein
FPL04_RS16880	COG0741	lytic transglycosylase activity
FPL04_RS16880	COG1196	nuclear chromosome segregation
FPL04_RS16880	COG0739	heme binding
FPL04_RS16885	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS16890	COG0583	DNA-binding transcription factor activity
FPL04_RS16895	COG4773	Receptor
FPL04_RS16900	COG0596	Alpha beta hydrolase
FPL04_RS16905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FPL04_RS16910	COG1301	dicarboxylic acid transport
FPL04_RS16945	COG0714	Associated with various cellular activities
FPL04_RS16975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FPL04_RS17000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FPL04_RS17010	COG2721	sulfolactate sulfo-lyase activity
FPL04_RS17025	COG2271	Major facilitator Superfamily
FPL04_RS17040	COG0583	DNA-binding transcription factor activity
FPL04_RS17050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPL04_RS17065	COG1561	YicC-like family, N-terminal region
FPL04_RS17070	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FPL04_RS17085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FPL04_RS17100	COG0006	proline dipeptidase activity
FPL04_RS17110	COG0006	proline dipeptidase activity
FPL04_RS17135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FPL04_RS17160	COG2912	Transglutaminase-like superfamily
FPL04_RS17165	COG1773	rubredoxin
FPL04_RS17170	COG0352	thiamine-phosphate diphosphorylase activity
FPL04_RS17190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FPL04_RS17205	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FPL04_RS17210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL04_RS17240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FPL04_RS17245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL04_RS17260	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS17270	COG0671	phosphoesterase, PA-phosphatase related
FPL04_RS17275	COG3781	membrane
FPL04_RS17285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPL04_RS17290	COG0563	adenylate kinase activity
FPL04_RS17305	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FPL04_RS17315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FPL04_RS17335	COG3710	Transcriptional regulator
FPL04_RS17340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FPL04_RS17355	COG0823	Involved in the tonB-independent uptake of proteins
FPL04_RS17355	COG1506	peptidase
FPL04_RS17355	COG4946	Tricorn protease homolog
FPL04_RS17360	COG0840	transmembrane signaling receptor activity
FPL04_RS17365	COG0405	Gamma-glutamyltransferase
FPL04_RS17370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FPL04_RS17390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FPL04_RS17400	COG0473	3-isopropylmalate dehydrogenase activity
FPL04_RS17405	COG0066	3-isopropylmalate dehydratase activity
FPL04_RS17410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FPL04_RS17430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FPL04_RS17435	COG1538	Outer membrane efflux protein
FPL04_RS17440	COG1519	Transferase
FPL04_RS17445	COG1560	Kdo2-lipid A biosynthetic process
FPL04_RS17470	COG0280	phosphate acetyltransferase
FPL04_RS17470	COG0281	malic enzyme
FPL04_RS17475	COG1301	dicarboxylic acid transport
FPL04_RS17485	COG4191	Histidine kinase
FPL04_RS17500	COG0583	DNA-binding transcription factor activity
FPL04_RS17515	COG0667	Aldo Keto reductase
FPL04_RS17520	COG2197	response regulator
FPL04_RS17530	COG0642	Histidine kinase
FPL04_RS17550	COG2851	Citrate transporter
FPL04_RS17555	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS17560	COG1609	Transcriptional regulator
FPL04_RS17565	COG2211	Major facilitator Superfamily
FPL04_RS17625	COG0436	Aminotransferase
FPL04_RS17650	COG4773	Receptor
FPL04_RS17655	COG0726	polysaccharide deacetylase
FPL04_RS17660	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FPL04_RS17675	COG3964	amidohydrolase
FPL04_RS17680	COG1228	amidohydrolase
FPL04_RS17705	COG1307	EDD domain protein, DegV family
FPL04_RS17720	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FPL04_RS17725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FPL04_RS17750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPL04_RS17750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPL04_RS17765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FPL04_RS17775	COG0488	(ABC) transporter
FPL04_RS17780	COG0242	peptide deformylase activity
FPL04_RS17800	COG0457	Tetratricopeptide repeat
FPL04_RS17805	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FPL04_RS17810	COG1215	transferase activity, transferring glycosyl groups
FPL04_RS17815	COG1215	transferase activity, transferring glycosyl groups
FPL04_RS17875	COG2188	Transcriptional regulator
FPL04_RS17885	COG1450	Type ii and iii secretion system protein
FPL04_RS17900	COG3166	PFAM Fimbrial assembly family protein
FPL04_RS17905	COG3156	type II secretion system protein K
FPL04_RS17910	COG4795	General secretion pathway protein
FPL04_RS17915	COG2165	general secretion pathway protein
FPL04_RS17920	COG4970	Tfp pilus assembly protein FimT
FPL04_RS17925	COG2165	general secretion pathway protein
FPL04_RS17930	COG1459	type II secretion system
FPL04_RS17935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FPL04_RS17940	COG1404	Belongs to the peptidase S8 family
FPL04_RS17945	COG5295	Hep Hag repeat protein
FPL04_RS17955	COG1404	Belongs to the peptidase S8 family
FPL04_RS17965	COG0047	phosphoribosylformylglycinamidine synthase activity
FPL04_RS17965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FPL04_RS17970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL04_RS17975	COG4974	Belongs to the 'phage' integrase family
FPL04_RS17990	COG0795	lipopolysaccharide-transporting ATPase activity
FPL04_RS18000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FPL04_RS18035	COG1183	phosphatidylcholine synthase activity
FPL04_RS18045	COG0442	prolyl-tRNA aminoacylation
FPL04_RS18060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPL04_RS18065	COG1127	ABC transporter
FPL04_RS18070	COG3218	ABC-type transport auxiliary lipoprotein component
FPL04_RS18070	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPL04_RS18100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FPL04_RS18105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FPL04_RS18135	COG2086	electron transfer activity
FPL04_RS18160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL04_RS18170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL04_RS18175	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FPL04_RS18190	COG0438	transferase activity, transferring glycosyl groups
FPL04_RS18215	COG0626	cystathionine gamma-synthase activity
FPL04_RS18245	COG0625	glutathione transferase activity
FPL04_RS18260	COG0513	Belongs to the DEAD box helicase family
FPL04_RS18270	COG4771	TonB-dependent receptor
FPL04_RS18275	COG0720	synthase
FPL04_RS18285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FPL04_RS18290	COG1956	GAF domain-containing protein
FPL04_RS18300	COG2819	hydrolase of the alpha beta superfamily
FPL04_RS18310	COG0546	phosphoglycolate phosphatase activity
FPL04_RS18315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FPL04_RS18330	COG0339	signal peptide processing
FPL04_RS18375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPL04_RS18380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_RS18385	COG1136	(ABC) transporter
FPL04_RS18390	COG0577	efflux transmembrane transporter activity
FPL04_RS18390	COG1136	(ABC) transporter
FPL04_RS18410	COG4191	Histidine kinase
FPL04_RS18420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FPL04_RS18435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FPL04_RS18455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FPL04_RS18460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FPL04_RS18470	COG0356	it plays a direct role in the translocation of protons across the membrane
FPL04_RS18485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL04_RS18495	COG0508	dehydrogenase complex catalyzes the overall conversion of
FPL04_RS18530	COG2011	ABC-type metal ion transport system permease component
FPL04_RS18535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FPL04_RS18540	COG0697	spore germination
FPL04_RS18545	COG1666	GTP binding
FPL04_RS18555	COG0784	Response regulator, receiver
FPL04_RS18555	COG2198	Histidine kinase
FPL04_RS18555	COG5002	protein histidine kinase activity
FPL04_RS18575	COG1187	pseudouridine synthase activity
FPL04_RS18600	COG2202	Pas domain
FPL04_RS18600	COG2205	protein histidine kinase activity
FPL04_RS18625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FPL04_RS18630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL04_RS18685	COG0842	Transport permease protein
FPL04_RS18690	COG1131	(ABC) transporter
FPL04_RS18695	COG0025	NhaP-type Na H and K H
FPL04_RS18710	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FPL04_RS18715	COG1573	uracil-dna glycosylase
FPL04_RS18725	COG3384	dioxygenase
FPL04_RS18735	COG0583	DNA-binding transcription factor activity
FPL04_RS18745	COG0667	Aldo Keto reductase
FPL04_RS18755	COG3590	peptidase
FPL04_RS18770	COG0531	amino acid
FPL04_RS18785	COG2972	Histidine kinase
FPL04_RS18800	COG3685	Protein conserved in bacteria
FPL04_RS18805	COG3546	catalase activity
FPL04_RS18830	COG2204	response regulator
FPL04_RS18840	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS18855	COG1063	alcohol dehydrogenase
FPL04_RS18880	COG0583	DNA-binding transcription factor activity
FPL04_RS18885	COG2814	Major facilitator Superfamily
FPL04_RS18920	COG1131	(ABC) transporter
FPL04_RS18935	COG0251	oxidation-reduction process
FPL04_RS18950	COG0840	transmembrane signaling receptor activity
FPL04_RS18985	COG0659	secondary active sulfate transmembrane transporter activity
FPL04_RS18990	COG0038	chloride channel
FPL04_RS18995	COG0024	Methionine aminopeptidase
FPL04_RS19010	COG1309	transcriptional regulator
FPL04_RS19020	COG1393	Belongs to the ArsC family
FPL04_RS19025	COG0431	NADPH-dependent FMN reductase
FPL04_RS19030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FPL04_RS19060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL04_RS19065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FPL04_RS19070	COG0300	oxidoreductase activity
FPL04_RS19080	COG0583	DNA-binding transcription factor activity
FPL04_RS19095	COG4695	Portal protein
FPL04_RS19335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FPL04_RS19340	COG1490	D-aminoacyl-tRNA deacylase activity
FPL04_RS19345	COG1560	Kdo2-lipid A biosynthetic process
FPL04_RS19355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FPL04_RS19390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FPL04_RS19390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FPL04_RS19400	COG0242	peptide deformylase activity
FPL04_RS19405	COG1652	LysM domain
FPL04_RS19410	COG0758	DNA mediated transformation
FPL04_RS19430	COG1754	DNA topoisomerase type I activity
FPL04_RS19430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FPL04_RS19435	COG0009	L-threonylcarbamoyladenylate synthase
FPL04_RS19450	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS19460	COG0616	signal peptide processing
FPL04_RS19465	COG0534	Mate efflux family protein
FPL04_RS19480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FPL04_RS19485	COG0625	glutathione transferase activity
FPL04_RS19500	COG1252	NADH dehydrogenase
FPL04_RS19505	COG2860	membrane
FPL04_RS19510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FPL04_RS19515	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FPL04_RS19520	COG2201	protein-glutamate methylesterase activity
FPL04_RS19525	COG2177	Part of the ABC transporter FtsEX involved in
FPL04_RS19530	COG2884	Cell division ATP-binding protein ftsE
FPL04_RS19540	COG3118	belongs to the thioredoxin family
FPL04_RS19545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FPL04_RS19555	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FPL04_RS19575	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FPL04_RS19575	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FPL04_RS19580	COG1473	amidohydrolase
FPL04_RS19590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL04_RS19605	COG5383	Protein conserved in bacteria
FPL04_RS19645	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FPL04_RS19665	COG3023	N-Acetylmuramoyl-L-alanine amidase
FPL04_RS19675	COG4948	Mandelate Racemase Muconate Lactonizing
FPL04_RS19685	COG0531	amino acid
FPL04_RS19705	COG2133	pyrroloquinoline quinone binding
FPL04_RS19715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FPL04_RS19730	COG1610	YqeY-like protein
FPL04_RS19735	COG1295	ribonuclease BN
FPL04_RS19740	COG0358	DNA primase activity
FPL04_RS19760	COG0109	protoheme IX farnesyltransferase activity
FPL04_RS19790	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FPL04_RS19805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FPL04_RS19850	COG0739	heme binding
FPL04_RS19865	COG2807	transmembrane transport
FPL04_RS19870	COG0708	Exodeoxyribonuclease III
FPL04_RS19885	COG1192	Involved in chromosome partitioning
FPL04_RS19890	COG1475	DNA binding
FPL04_RS19910	COG0463	Glycosyl transferase, family 2
FPL04_RS19935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FPL04_RS19945	COG0018	arginyl-trna synthetase
FPL04_RS19960	COG4221	oxidoreductase activity
FPL04_RS19965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FPL04_RS19965	COG2755	lipolytic protein G-D-S-L family
FPL04_RS19975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_RS19975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_RS19980	COG1166	arginine decarboxylase activity
FPL04_RS19985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FPL04_RS20020	COG0606	chelatase, subunit chli
FPL04_RS20035	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FPL04_RS20085	COG1090	epimerase
FPL04_RS20095	COG0642	Histidine kinase
FPL04_RS20145	COG1011	Hydrolase
FPL04_RS20150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FPL04_RS20180	COG2197	response regulator
FPL04_RS20185	COG4585	Histidine kinase
FPL04_RS20190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_RS20195	COG1136	(ABC) transporter
FPL04_RS20220	COG0697	spore germination
FPL04_RS20245	COG0180	Tryptophanyl-tRNA synthetase
FPL04_RS20250	COG3237	CsbD-like
FPL04_RS20295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FPL04_RS20310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FPL04_RS20315	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FPL04_RS20315	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FPL04_RS20355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPL04_RS20380	COG1199	ATP-dependent helicase activity
FPL04_RS20445	COG0625	glutathione transferase activity
FPL04_RS20480	COG4555	ABC transporter
FPL04_RS20490	COG1476	TRANSCRIPTIONal
FPL04_RS20520	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FPL04_RS20525	COG1131	(ABC) transporter
FPL04_RS20530	COG0842	Transport permease protein
FPL04_RS20535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FPL04_RS20545	COG1607	acyl-coa hydrolase
FPL04_RS20565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FPL04_RS20570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FPL04_RS20580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FPL04_RS20580	COG1042	CoA-binding domain protein
FPL04_RS20580	COG0045	succinate-CoA ligase (ADP-forming) activity
FPL04_RS20585	COG2239	Acts as a magnesium transporter
FPL04_RS20600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FPL04_RS20605	COG3387	PFAM Glycoside hydrolase 15-related
FPL04_RS20620	COG3100	YcgL domain-containing protein
FPL04_RS20625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FPL04_RS20655	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS20680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPL04_RS20695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPL04_RS20780	COG3621	Patatin-like phospholipase
FPL04_RS20800	COG0210	DNA helicase
FPL04_RS20815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL04_RS20820	COG0583	DNA-binding transcription factor activity
FPL04_RS20825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FPL04_RS20835	COG2159	amidohydrolase
FPL04_RS20855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_RS20880	COG3540	Alkaline phosphatase
FPL04_RS20890	COG2091	lysine biosynthetic process via aminoadipic acid
FPL04_RS20910	COG1940	carbohydrate kinase activity
FPL04_RS20920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL04_RS20935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FPL04_RS20940	COG3162	membrane
FPL04_RS20985	COG3507	Belongs to the glycosyl hydrolase 43 family
FPL04_RS21000	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS21005	COG0179	Fumarylacetoacetate (FAA) hydrolase
FPL04_RS21010	COG4948	Mandelate Racemase Muconate Lactonizing
FPL04_RS21015	COG3254	rhamnose metabolic process
FPL04_RS21020	COG0738	Major facilitator superfamily
FPL04_RS21025	COG1414	Transcriptional regulator
FPL04_RS21035	COG1971	Probably functions as a manganese efflux pump
FPL04_RS21040	COG0784	Response regulator, receiver
FPL04_RS21040	COG2205	protein histidine kinase activity
FPL04_RS21045	COG3459	Glycosyltransferase 36 associated
FPL04_RS21050	COG2211	Major facilitator Superfamily
FPL04_RS21055	COG3265	gluconokinase activity
FPL04_RS21060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL04_RS21090	COG2911	Protein conserved in bacteria
FPL04_RS21095	COG0729	surface antigen
FPL04_RS21100	COG4771	TonB-dependent receptor
FPL04_RS21105	COG0457	Tetratricopeptide repeat
FPL04_RS21125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FPL04_RS21130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FPL04_RS21130	COG0519	Catalyzes the synthesis of GMP from XMP
FPL04_RS21140	COG0805	protein transport
FPL04_RS21145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FPL04_RS21150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FPL04_RS21160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FPL04_RS21175	COG2974	May be involved in recombination
FPL04_RS21180	COG0037	tRNA processing
FPL04_RS21190	COG2115	Belongs to the xylose isomerase family
FPL04_RS21200	COG3661	Belongs to the glycosyl hydrolase 67 family
FPL04_RS21210	COG4948	Mandelate Racemase Muconate Lactonizing
FPL04_RS21220	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL04_RS21225	COG0246	Mannitol dehydrogenase
FPL04_RS21245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FPL04_RS21280	COG3386	PFAM SMP-30 Gluconolaconase
FPL04_RS21290	COG3250	beta-galactosidase activity
FPL04_RS21295	COG1904	glucuronate isomerase
FPL04_RS21300	COG3693	PFAM glycoside hydrolase, family 10
FPL04_RS21315	COG2211	Major facilitator Superfamily
FPL04_RS21345	COG0604	alcohol dehydrogenase
FPL04_RS21345	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_RS21345	COG3321	synthase
FPL04_RS21350	COG2937	Belongs to the GPAT DAPAT family
FPL04_RS21380	COG0284	orotidine-5'-phosphate decarboxylase activity
FPL04_RS21385	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FPL04_RS21395	COG3132	Protein of unknown function, DUF480
FPL04_RS21405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FPL04_RS21455	COG0210	DNA helicase
FPL04_RS21460	COG1435	thymidine kinase activity
FPL04_RS21470	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FPL04_RS21480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FPL04_RS21510	COG3135	benzoate transporter
FPL04_RS21535	COG0676	glucose-6-phosphate 1-epimerase activity
FPL04_RS21550	COG0730	response to heat
FPL04_RS21570	COG0302	gtp cyclohydrolase
FPL04_RS21585	COG1566	PFAM secretion protein HlyD family protein
FPL04_RS21595	COG1289	transmembrane transporter activity
FPL04_RS21600	COG0477	Major facilitator Superfamily
FPL04_RS21605	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FPL04_RS21610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL04_RS21665	COG0564	pseudouridine synthase activity
FPL04_RS21735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FPL04_RS21740	COG1074	ATP-dependent DNA helicase activity
FPL04_RS21740	COG1074	ATP-dependent DNA helicase activity
FPL04_RS21745	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FPL04_RS21780	COG1127	ABC transporter
FPL04_RS21785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPL04_RS21790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPL04_RS21805	COG2853	Lipoprotein
FPL04_RS21810	COG0386	Belongs to the glutathione peroxidase family
FPL04_RS21820	COG1322	Protein conserved in bacteria
FPL04_RS21830	COG0531	amino acid
FPL04_RS21835	COG3537	Alpha-1,2-mannosidase
FPL04_RS21850	COG3706	GGDEF domain
FPL04_RS21855	COG3835	regulator
FPL04_RS21860	COG1929	Belongs to the glycerate kinase type-1 family
FPL04_RS21865	COG2271	Major facilitator Superfamily
FPL04_RS21880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FPL04_RS21890	COG0861	Integral membrane protein TerC family
FPL04_RS21900	COG0584	glycerophosphoryl diester phosphodiesterase
FPL04_RS21910	COG0671	phosphoesterase, PA-phosphatase related
FPL04_RS21920	COG0726	polysaccharide deacetylase
FPL04_RS21925	COG0706	membrane insertase activity