locus-tag	class	description
K9U01_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K9U01_RS00020	COG0187	DNA topoisomerase II activity
K9U01_RS00030	COG0501	Belongs to the peptidase M48B family
K9U01_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K9U01_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K9U01_RS00105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K9U01_RS00110	COG0793	Belongs to the peptidase S41A family
K9U01_RS00115	COG4942	peptidase
K9U01_RS00125	COG2234	aminopeptidase activity
K9U01_RS00135	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K9U01_RS00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K9U01_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K9U01_RS00150	COG1064	alcohol dehydrogenase
K9U01_RS00160	COG0493	'glutamate synthase
K9U01_RS00165	COG0067	glutamate synthase
K9U01_RS00165	COG0069	glutamate synthase activity
K9U01_RS00165	COG0070	glutamate synthase
K9U01_RS00200	COG3459	Glycosyltransferase 36 associated
K9U01_RS00250	COG1111	helicase
K9U01_RS00250	COG1205	dead DEAH box helicase
K9U01_RS00255	COG1272	protein, Hemolysin III
K9U01_RS00295	COG0583	DNA-binding transcription factor activity
K9U01_RS00300	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS00315	COG1733	regulation of RNA biosynthetic process
K9U01_RS00345	COG3237	CsbD-like
K9U01_RS00380	COG0657	acetylesterase activity
K9U01_RS00390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K9U01_RS00435	COG1309	transcriptional regulator
K9U01_RS00460	COG4772	TonB-dependent receptor
K9U01_RS00470	COG2423	ornithine cyclodeaminase activity
K9U01_RS00480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K9U01_RS00485	COG0765	amino acid transport
K9U01_RS00495	COG3284	Transcriptional regulator
K9U01_RS00500	COG1012	belongs to the aldehyde dehydrogenase family
K9U01_RS00530	COG1304	FMN binding
K9U01_RS00535	COG1755	Isoprenylcysteine carboxyl methyltransferase
K9U01_RS00540	COG4585	Histidine kinase
K9U01_RS00565	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K9U01_RS00645	COG1595	DNA-templated transcription, initiation
K9U01_RS00685	COG0366	Alpha amylase catalytic
K9U01_RS00690	COG0366	Alpha amylase catalytic
K9U01_RS00695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K9U01_RS00740	COG0657	acetylesterase activity
K9U01_RS00740	COG2755	lipolytic protein G-D-S-L family
K9U01_RS00750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K9U01_RS00765	COG3507	Belongs to the glycosyl hydrolase 43 family
K9U01_RS00770	COG1609	Transcriptional regulator
K9U01_RS00775	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K9U01_RS00780	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS00790	COG2755	lipolytic protein G-D-S-L family
K9U01_RS00800	COG3186	Phenylalanine-4-hydroxylase
K9U01_RS00805	COG1522	sequence-specific DNA binding
K9U01_RS00815	COG1752	Esterase of the alpha-beta hydrolase superfamily
K9U01_RS00825	COG1119	ATPase activity
K9U01_RS00840	COG1125	glycine betaine transport
K9U01_RS00840	COG0517	IMP dehydrogenase activity
K9U01_RS00855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K9U01_RS00860	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K9U01_RS00890	COG0489	protein tyrosine kinase activity
K9U01_RS00895	COG2062	phosphohistidine phosphatase, SixA
K9U01_RS00900	COG2353	YceI-like domain
K9U01_RS00905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K9U01_RS00930	COG1881	PFAM PEBP family protein
K9U01_RS00945	COG0174	glutamine synthetase
K9U01_RS00950	COG0347	Belongs to the P(II) protein family
K9U01_RS00955	COG0004	ammonium transporteR
K9U01_RS00960	COG3852	Histidine kinase
K9U01_RS00965	COG2204	response regulator
K9U01_RS00970	COG2032	superoxide dismutase activity
K9U01_RS00975	COG2032	superoxide dismutase activity
K9U01_RS00990	COG0183	Belongs to the thiolase family
K9U01_RS01030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K9U01_RS01040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K9U01_RS01050	COG0028	Belongs to the TPP enzyme family
K9U01_RS01055	COG2205	protein histidine kinase activity
K9U01_RS01080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K9U01_RS01095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K9U01_RS01100	COG3177	Filamentation induced by cAMP protein fic
K9U01_RS01115	COG0596	Alpha beta hydrolase
K9U01_RS01120	COG0727	PFAM Uncharacterised protein family (UPF0153)
K9U01_RS01125	COG0318	PFAM AMP-dependent synthetase and ligase
K9U01_RS01130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K9U01_RS01145	COG1181	Belongs to the D-alanine--D-alanine ligase family
K9U01_RS01165	COG0564	pseudouridine synthase activity
K9U01_RS01185	COG1446	asparaginase
K9U01_RS01190	COG0339	signal peptide processing
K9U01_RS01195	COG0681	Belongs to the peptidase S26 family
K9U01_RS01220	COG0475	glutathione-regulated potassium exporter activity
K9U01_RS01225	COG0583	DNA-binding transcription factor activity
K9U01_RS01230	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K9U01_RS01235	COG2224	Isocitrate lyase
K9U01_RS01265	COG4770	biotin carboxylase activity
K9U01_RS01270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K9U01_RS01275	COG1960	acyl-CoA dehydrogenase activity
K9U01_RS01330	COG0523	cobalamin synthesis protein
K9U01_RS01340	COG0697	spore germination
K9U01_RS01350	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K9U01_RS01355	COG1846	Transcriptional regulator
K9U01_RS01360	COG1764	response to oxidative stress
K9U01_RS01385	COG0656	L-ascorbic acid biosynthetic process
K9U01_RS01390	COG2130	NADP-dependent
K9U01_RS01405	COG1187	pseudouridine synthase activity
K9U01_RS01415	COG1643	Atp-dependent helicase
K9U01_RS01420	COG0840	transmembrane signaling receptor activity
K9U01_RS01425	COG4807	Protein conserved in bacteria
K9U01_RS01430	COG2351	hydroxyisourate hydrolase activity
K9U01_RS01435	COG2072	flavoprotein involved in K transport
K9U01_RS01455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K9U01_RS01505	COG1957	nucleoside hydrolase
K9U01_RS01530	COG0084	hydrolase, TatD family'
K9U01_RS01545	COG0583	DNA-binding transcription factor activity
K9U01_RS01550	COG2814	Major facilitator Superfamily
K9U01_RS01555	COG1404	Belongs to the peptidase S8 family
K9U01_RS01575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K9U01_RS01580	COG1902	pentaerythritol trinitrate reductase activity
K9U01_RS01600	COG2223	nitrite transmembrane transporter activity
K9U01_RS01605	COG0745	RESPONSE REGULATOR receiver
K9U01_RS01620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9U01_RS01640	COG0577	efflux transmembrane transporter activity
K9U01_RS01645	COG0577	efflux transmembrane transporter activity
K9U01_RS01645	COG1136	(ABC) transporter
K9U01_RS01695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K9U01_RS01700	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K9U01_RS01705	COG0583	DNA-binding transcription factor activity
K9U01_RS01730	COG0702	epimerase
K9U01_RS01735	COG1733	regulation of RNA biosynthetic process
K9U01_RS01745	COG0840	transmembrane signaling receptor activity
K9U01_RS01790	COG0129	dihydroxy-acid dehydratase activity
K9U01_RS01810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K9U01_RS01865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K9U01_RS01895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K9U01_RS01900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K9U01_RS01910	COG3485	protocatechuate 3,4-dioxygenase
K9U01_RS01915	COG3485	protocatechuate 3,4-dioxygenase
K9U01_RS01925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K9U01_RS01930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K9U01_RS01940	COG1414	Transcriptional regulator
K9U01_RS01960	COG0445	tRNA wobble uridine modification
K9U01_RS01970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K9U01_RS02010	COG0156	8-amino-7-oxononanoate synthase activity
K9U01_RS02015	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K9U01_RS02020	COG1040	competence protein
K9U01_RS02090	COG4771	TonB-dependent receptor
K9U01_RS02115	COG1169	isochorismate synthase
K9U01_RS02145	COG3433	isochorismatase activity
K9U01_RS02145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9U01_RS02145	COG2226	methyltransferase
K9U01_RS02160	COG4771	TonB-dependent receptor
K9U01_RS02165	COG1132	(ABC) transporter
K9U01_RS02165	COG2375	cellular response to nickel ion
K9U01_RS02170	COG1132	(ABC) transporter
K9U01_RS02190	COG2801	Transposase and inactivated derivatives
K9U01_RS02200	COG3264	Mechanosensitive ion channel
K9U01_RS02200	COG1511	domain protein
K9U01_RS02205	COG1368	sulfuric ester hydrolase activity
K9U01_RS02210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K9U01_RS02215	COG2354	Protein conserved in bacteria
K9U01_RS02225	COG0297	glycogen (starch) synthase activity
K9U01_RS02230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K9U01_RS02235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K9U01_RS02260	COG0702	epimerase
K9U01_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS02305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K9U01_RS02310	COG4221	oxidoreductase activity
K9U01_RS02325	COG0513	Belongs to the DEAD box helicase family
K9U01_RS02335	COG0508	dehydrogenase complex catalyzes the overall conversion of
K9U01_RS02350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K9U01_RS02365	COG3104	oligopeptide transport
K9U01_RS02385	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K9U01_RS02400	COG1320	monovalent cation:proton antiporter activity
K9U01_RS02405	COG2212	antiporter activity
K9U01_RS02415	COG0651	ATP synthesis coupled electron transport
K9U01_RS02420	COG1006	Multisubunit Na H antiporter MnhC subunit
K9U01_RS02425	COG2111	Na H antiporter
K9U01_RS02425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K9U01_RS02470	COG0484	heat shock protein binding
K9U01_RS02490	COG1597	lipid kinase activity
K9U01_RS02510	COG0583	DNA-binding transcription factor activity
K9U01_RS02515	COG0583	DNA-binding transcription factor activity
K9U01_RS02520	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
K9U01_RS02530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K9U01_RS02615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K9U01_RS02695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K9U01_RS02700	COG0134	indole-3-glycerol-phosphate synthase activity
K9U01_RS02710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K9U01_RS02725	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K9U01_RS02735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K9U01_RS02750	COG1051	belongs to the nudix hydrolase family
K9U01_RS02790	COG0316	Belongs to the HesB IscA family
K9U01_RS02805	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K9U01_RS02830	COG2814	Major facilitator Superfamily
K9U01_RS02835	COG1289	transmembrane transporter activity
K9U01_RS02840	COG0151	Belongs to the GarS family
K9U01_RS02845	COG0138	bifunctional purine biosynthesis protein purh
K9U01_RS02865	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K9U01_RS02885	COG2264	protein methyltransferase activity
K9U01_RS02900	COG0439	Biotin carboxylase
K9U01_RS02910	COG0511	ligase activity, forming carbon-carbon bonds
K9U01_RS02915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K9U01_RS02930	COG1324	tolerance protein
K9U01_RS02935	COG2356	endonuclease I
K9U01_RS02965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K9U01_RS02990	COG3712	iron ion homeostasis
K9U01_RS03015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K9U01_RS03045	COG2353	YceI-like domain
K9U01_RS03065	COG3052	prosthetic group binding
K9U01_RS03100	COG1802	Transcriptional regulator
K9U01_RS03105	COG0546	phosphoglycolate phosphatase activity
K9U01_RS03200	COG1595	DNA-templated transcription, initiation
K9U01_RS03215	COG4206	TonB-dependent receptor
K9U01_RS03220	COG1506	peptidase
K9U01_RS03220	COG0823	Involved in the tonB-independent uptake of proteins
K9U01_RS03275	COG0435	Glutathione S-transferase
K9U01_RS03310	COG0823	Involved in the tonB-independent uptake of proteins
K9U01_RS03310	COG1506	peptidase
K9U01_RS03360	COG0697	spore germination
K9U01_RS03380	COG1113	amino acid transport
K9U01_RS03440	COG0840	transmembrane signaling receptor activity
K9U01_RS03445	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K9U01_RS03445	COG5297	Belongs to the glycosyl hydrolase family 6
K9U01_RS03450	COG0659	secondary active sulfate transmembrane transporter activity
K9U01_RS03465	COG2943	transferase activity, transferring hexosyl groups
K9U01_RS03475	COG3275	phosphorelay sensor kinase activity
K9U01_RS03485	COG0181	hydroxymethylbilane synthase activity
K9U01_RS03510	COG1505	serine-type exopeptidase activity
K9U01_RS03515	COG0436	Aminotransferase
K9U01_RS03525	COG2832	Protein of unknown function (DUF454)
K9U01_RS03535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K9U01_RS03550	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K9U01_RS03585	COG3300	MHYT domain
K9U01_RS03585	COG5001	Diguanylate cyclase
K9U01_RS03590	COG0308	aminopeptidase N
K9U01_RS03625	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K9U01_RS03635	COG3284	Transcriptional regulator
K9U01_RS03640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K9U01_RS03645	COG1077	Cell shape determining protein MreB Mrl
K9U01_RS03655	COG1792	Involved in formation and maintenance of cell shape
K9U01_RS03670	COG0772	Belongs to the SEDS family
K9U01_RS03680	COG2951	lytic endotransglycosylase activity
K9U01_RS03685	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K9U01_RS03690	COG1686	Belongs to the peptidase S11 family
K9U01_RS03700	COG2921	Belongs to the UPF0250 family
K9U01_RS03705	COG0321	lipoyl(octanoyl) transferase activity
K9U01_RS03710	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K9U01_RS03725	COG0583	DNA-binding transcription factor activity
K9U01_RS03735	COG1051	belongs to the nudix hydrolase family
K9U01_RS03735	COG1056	cytidyltransferase-related domain
K9U01_RS03750	COG2813	Specifically methylates the guanine in position
K9U01_RS03770	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K9U01_RS03775	COG0673	inositol 2-dehydrogenase activity
K9U01_RS03780	COG2823	Periplasmic or secreted lipoprotein
K9U01_RS03785	COG4251	negative regulation of phosphorylation
K9U01_RS03790	COG0784	Response regulator, receiver
K9U01_RS03795	COG4191	Histidine kinase
K9U01_RS03800	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K9U01_RS03805	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS03850	COG1459	type II secretion system
K9U01_RS03900	COG3250	beta-galactosidase activity
K9U01_RS03915	COG2188	Transcriptional regulator
K9U01_RS03925	COG1609	Transcriptional regulator
K9U01_RS03930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K9U01_RS03935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K9U01_RS03950	COG0617	tRNA 3'-terminal CCA addition
K9U01_RS03965	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K9U01_RS03970	COG1012	belongs to the aldehyde dehydrogenase family
K9U01_RS03975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K9U01_RS03985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K9U01_RS04000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K9U01_RS04005	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K9U01_RS04020	COG2205	protein histidine kinase activity
K9U01_RS04040	COG3920	Histidine kinase
K9U01_RS04055	COG3791	Glutathione-dependent formaldehyde-activating
K9U01_RS04065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K9U01_RS04075	COG0697	spore germination
K9U01_RS04095	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K9U01_RS04100	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K9U01_RS04105	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K9U01_RS04110	COG2205	protein histidine kinase activity
K9U01_RS04115	COG0745	RESPONSE REGULATOR receiver
K9U01_RS04120	COG1506	peptidase
K9U01_RS04120	COG0823	Involved in the tonB-independent uptake of proteins
K9U01_RS04120	COG4946	Tricorn protease homolog
K9U01_RS04125	COG0277	FAD linked oxidase domain protein
K9U01_RS04130	COG1988	membrane-bound metal-dependent
K9U01_RS04135	COG0792	nuclease activity
K9U01_RS04170	COG3116	cell division
K9U01_RS04180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K9U01_RS04185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K9U01_RS04205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K9U01_RS04210	COG1181	Belongs to the D-alanine--D-alanine ligase family
K9U01_RS04215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K9U01_RS04240	COG0739	heme binding
K9U01_RS04245	COG0653	protein targeting
K9U01_RS04255	COG0494	nUDIX hydrolase
K9U01_RS04270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K9U01_RS04275	COG3321	synthase
K9U01_RS04275	COG0604	alcohol dehydrogenase
K9U01_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS04295	COG0366	Alpha amylase catalytic
K9U01_RS04320	COG2226	methyltransferase
K9U01_RS04335	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K9U01_RS04365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K9U01_RS04380	COG4106	trans-aconitate 2-methyltransferase activity
K9U01_RS04385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K9U01_RS04395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K9U01_RS04400	COG0667	Aldo Keto reductase
K9U01_RS04410	COG4771	TonB-dependent receptor
K9U01_RS04430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K9U01_RS04435	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
K9U01_RS04445	COG2175	clavaminate synthase activity
K9U01_RS04455	COG4181	ATPase activity
K9U01_RS04470	COG0642	Histidine kinase
K9U01_RS04480	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K9U01_RS04500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K9U01_RS04505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K9U01_RS04515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K9U01_RS04520	COG2967	ApaG domain
K9U01_RS04525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K9U01_RS04530	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K9U01_RS04540	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K9U01_RS04545	COG0123	including yeast histone deacetylase and acetoin utilization protein
K9U01_RS04550	COG2096	Adenosyltransferase
K9U01_RS04560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9U01_RS04565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9U01_RS04595	COG3384	dioxygenase
K9U01_RS04600	COG0583	DNA-binding transcription factor activity
K9U01_RS04605	COG0318	PFAM AMP-dependent synthetase and ligase
K9U01_RS04615	COG1024	Enoyl-CoA hydratase
K9U01_RS04665	COG0697	spore germination
K9U01_RS04670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K9U01_RS04695	COG2197	response regulator
K9U01_RS04705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K9U01_RS04715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K9U01_RS04720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K9U01_RS04725	COG0583	DNA-binding transcription factor activity
K9U01_RS04730	COG3634	alkyl hydroperoxide reductase activity
K9U01_RS04740	COG2890	protein-(glutamine-N5) methyltransferase activity
K9U01_RS04760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K9U01_RS04760	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K9U01_RS04790	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K9U01_RS04835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K9U01_RS04840	COG1404	Belongs to the peptidase S8 family
K9U01_RS04845	COG1404	Belongs to the peptidase S8 family
K9U01_RS04850	COG1404	Belongs to the peptidase S8 family
K9U01_RS04855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K9U01_RS04875	COG1295	ribonuclease BN
K9U01_RS04880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K9U01_RS04885	COG1254	Belongs to the acylphosphatase family
K9U01_RS04900	COG0521	Mo-molybdopterin cofactor biosynthetic process
K9U01_RS04910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K9U01_RS04915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K9U01_RS04925	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K9U01_RS04940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K9U01_RS04945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K9U01_RS04950	COG0193	aminoacyl-tRNA hydrolase activity
K9U01_RS04955	COG0012	GTP binding
K9U01_RS04975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K9U01_RS04985	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K9U01_RS04990	COG0250	Participates in transcription elongation, termination and antitermination
K9U01_RS04995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K9U01_RS05000	COG0081	regulation of translation
K9U01_RS05005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K9U01_RS05010	COG0222	ribosome binding
K9U01_RS05020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K9U01_RS05025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K9U01_RS05035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K9U01_RS05040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K9U01_RS05045	COG0051	transcription antitermination factor activity, RNA binding
K9U01_RS05065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K9U01_RS05075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K9U01_RS05090	COG0255	Belongs to the universal ribosomal protein uL29 family
K9U01_RS05105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K9U01_RS05125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K9U01_RS05140	COG1841	ribosomal large subunit assembly
K9U01_RS05150	COG0201	protein transport
K9U01_RS05175	COG0203	ribosomal protein L17
K9U01_RS05185	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K9U01_RS05195	COG0154	amidase activity
K9U01_RS05205	COG1217	gtp-binding protein TYPA
K9U01_RS05210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K9U01_RS05220	COG0625	glutathione transferase activity
K9U01_RS05235	COG0446	pyridine nucleotide-disulphide oxidoreductase
K9U01_RS05235	COG1902	pentaerythritol trinitrate reductase activity
K9U01_RS05240	COG0604	alcohol dehydrogenase
K9U01_RS05245	COG2885	chlorophyll binding
K9U01_RS05270	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K9U01_RS05275	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K9U01_RS05280	COG4208	sulfate ABC transporter
K9U01_RS05285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K9U01_RS05315	COG0406	alpha-ribazole phosphatase activity
K9U01_RS05325	COG0285	dihydrofolate synthase activity
K9U01_RS05345	COG2833	Protein of unknown function (DUF455)
K9U01_RS05350	COG3291	Pkd domain containing protein
K9U01_RS05360	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K9U01_RS05365	COG0671	phosphoesterase, PA-phosphatase related
K9U01_RS05370	COG0438	transferase activity, transferring glycosyl groups
K9U01_RS05380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K9U01_RS05395	COG4783	chaperone-mediated protein folding
K9U01_RS05410	COG0473	3-isopropylmalate dehydrogenase activity
K9U01_RS05445	COG0784	Response regulator, receiver
K9U01_RS05445	COG4191	Histidine kinase
K9U01_RS05455	COG0544	peptidyl-prolyl cis-trans isomerase activity
K9U01_RS05465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K9U01_RS05495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K9U01_RS05505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K9U01_RS05525	COG0631	protein serine/threonine phosphatase activity
K9U01_RS05540	COG0859	PFAM glycosyl transferase family 9
K9U01_RS05550	COG1234	tRNA 3'-trailer cleavage
K9U01_RS05555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K9U01_RS05560	COG0315	cyclic pyranopterin monophosphate synthase activity
K9U01_RS05565	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K9U01_RS05570	COG0314	molybdopterin synthase activity
K9U01_RS05590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K9U01_RS05595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K9U01_RS05600	COG0537	adenosine 5'-monophosphoramidase activity
K9U01_RS05620	COG0714	Associated with various cellular activities
K9U01_RS05640	COG0424	maF-like protein
K9U01_RS05645	COG1399	metal-binding, possibly nucleic acid-binding protein
K9U01_RS05650	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K9U01_RS05655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K9U01_RS05665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K9U01_RS05670	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS05685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K9U01_RS05690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K9U01_RS05715	COG3829	transcription factor binding
K9U01_RS05735	COG3609	addiction module antidote protein, CC2985 family
K9U01_RS05790	COG4953	penicillin-binding protein 1C
K9U01_RS05800	COG0678	peroxiredoxin activity
K9U01_RS05820	COG0330	HflC and HflK could
K9U01_RS05825	COG0330	HflC and HflK could
K9U01_RS05840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K9U01_RS05845	COG0308	aminopeptidase N
K9U01_RS05865	COG1309	transcriptional regulator
K9U01_RS05910	COG1309	transcriptional regulator
K9U01_RS05920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K9U01_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS05940	COG3537	Alpha-1,2-mannosidase
K9U01_RS05980	COG2323	membrane
K9U01_RS05995	COG2271	Major facilitator Superfamily
K9U01_RS06020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K9U01_RS06025	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K9U01_RS06030	COG2080	2 iron, 2 sulfur cluster binding
K9U01_RS06090	COG0587	DNA-directed DNA polymerase activity
K9U01_RS06100	COG1297	OPT oligopeptide transporter protein
K9U01_RS06120	COG1506	peptidase
K9U01_RS06120	COG0823	Involved in the tonB-independent uptake of proteins
K9U01_RS06135	COG1917	Cupin 2, conserved barrel domain protein
K9U01_RS06135	COG2207	Transcriptional regulator
K9U01_RS06140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9U01_RS06175	COG0753	catalase activity
K9U01_RS06180	COG0656	L-ascorbic acid biosynthetic process
K9U01_RS06185	COG2272	Belongs to the type-B carboxylesterase lipase family
K9U01_RS06190	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K9U01_RS06190	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K9U01_RS06220	COG2194	sulfuric ester hydrolase activity
K9U01_RS06230	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K9U01_RS06235	COG0745	RESPONSE REGULATOR receiver
K9U01_RS06240	COG5002	protein histidine kinase activity
K9U01_RS06255	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K9U01_RS06260	COG2894	cell division
K9U01_RS06275	COG4585	Histidine kinase
K9U01_RS06280	COG2197	response regulator
K9U01_RS06295	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K9U01_RS06330	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K9U01_RS06340	COG1595	DNA-templated transcription, initiation
K9U01_RS06350	COG1946	Acyl-CoA thioesterase
K9U01_RS06355	COG1024	Enoyl-CoA hydratase
K9U01_RS06365	COG0824	Thioesterase
K9U01_RS06370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K9U01_RS06380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K9U01_RS06385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K9U01_RS06395	COG0728	peptidoglycan biosynthetic process
K9U01_RS06410	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K9U01_RS06415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K9U01_RS06430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K9U01_RS06435	COG1845	cytochrome c oxidase, subunit III
K9U01_RS06440	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K9U01_RS06455	COG3152	Membrane
K9U01_RS06465	COG2207	Transcriptional regulator
K9U01_RS06470	COG0326	Molecular chaperone. Has ATPase activity
K9U01_RS06480	COG1902	pentaerythritol trinitrate reductase activity
K9U01_RS06485	COG1366	Belongs to the anti-sigma-factor antagonist family
K9U01_RS06490	COG1366	Belongs to the anti-sigma-factor antagonist family
K9U01_RS06495	COG2172	sigma factor antagonist activity
K9U01_RS06525	COG4771	TonB-dependent receptor
K9U01_RS06535	COG5507	3-demethylubiquinone-9 3-methyltransferase
K9U01_RS06540	COG2205	protein histidine kinase activity
K9U01_RS06550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K9U01_RS06555	COG3437	response regulator, receiver
K9U01_RS06555	COG2205	protein histidine kinase activity
K9U01_RS06555	COG3850	Histidine kinase
K9U01_RS06555	COG4999	Histidine kinase
K9U01_RS06560	COG0784	Response regulator, receiver
K9U01_RS06560	COG4191	Histidine kinase
K9U01_RS06610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K9U01_RS06615	COG2070	2-Nitropropane dioxygenase
K9U01_RS06635	COG0336	Belongs to the RNA methyltransferase TrmD family
K9U01_RS06665	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K9U01_RS06725	COG3209	COG3209 Rhs family protein
K9U01_RS06795	COG0840	transmembrane signaling receptor activity
K9U01_RS06820	COG2814	Major facilitator Superfamily
K9U01_RS06840	COG2003	Belongs to the UPF0758 family
K9U01_RS06860	COG0322	excinuclease ABC activity
K9U01_RS06900	COG3250	beta-galactosidase activity
K9U01_RS06905	COG3867	Arabinogalactan endo-beta-1,4-galactanase
K9U01_RS06915	COG1396	sequence-specific DNA binding
K9U01_RS06915	COG3800	Transcriptional regulator
K9U01_RS06925	COG1960	acyl-CoA dehydrogenase activity
K9U01_RS06950	COG1024	Enoyl-CoA hydratase
K9U01_RS06950	COG1250	3-hydroxyacyl-CoA dehydrogenase
K9U01_RS06965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K9U01_RS06970	COG0481	GTPase activity
K9U01_RS06985	COG0571	ribonuclease III activity
K9U01_RS06990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K9U01_RS06995	COG1381	Involved in DNA repair and RecF pathway recombination
K9U01_RS07010	COG2954	triphosphatase activity
K9U01_RS07015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K9U01_RS07020	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
K9U01_RS07025	COG3046	protein related to deoxyribodipyrimidine photolyase
K9U01_RS07030	COG1472	Belongs to the glycosyl hydrolase 3 family
K9U01_RS07035	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K9U01_RS07040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K9U01_RS07045	COG1278	Cold shock
K9U01_RS07050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9U01_RS07060	COG1201	RNA secondary structure unwinding
K9U01_RS07065	COG1793	dna ligase
K9U01_RS07075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K9U01_RS07075	COG1793	dna ligase
K9U01_RS07105	COG0183	Belongs to the thiolase family
K9U01_RS07125	COG1451	nucleotide metabolic process
K9U01_RS07130	COG5487	UPF0391 membrane protein
K9U01_RS07140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K9U01_RS07185	COG1047	Peptidyl-prolyl cis-trans
K9U01_RS07195	COG2824	Alkylphosphonate utilization operon protein PhnA
K9U01_RS07215	COG1902	pentaerythritol trinitrate reductase activity
K9U01_RS07220	COG2814	Major facilitator Superfamily
K9U01_RS07260	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K9U01_RS07260	COG0392	lysyltransferase activity
K9U01_RS07270	COG0251	oxidation-reduction process
K9U01_RS07275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K9U01_RS07290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K9U01_RS07315	COG1595	DNA-templated transcription, initiation
K9U01_RS07330	COG2878	Part of a membrane complex involved in electron transport
K9U01_RS07340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K9U01_RS07340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K9U01_RS07360	COG0346	lactoylglutathione lyase activity
K9U01_RS07380	COG0833	amino acid
K9U01_RS07385	COG2040	homocysteine
K9U01_RS07405	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K9U01_RS07425	COG1695	Transcriptional regulator
K9U01_RS07445	COG1981	membrane
K9U01_RS07455	COG0825	malonyl-CoA metabolic process
K9U01_RS07470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K9U01_RS07475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K9U01_RS07485	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K9U01_RS07500	COG0750	zinc metalloprotease
K9U01_RS07505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K9U01_RS07510	COG0575	Belongs to the CDS family
K9U01_RS07520	COG0233	cytoplasmic translational termination
K9U01_RS07525	COG0528	UMP kinase activity
K9U01_RS07535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K9U01_RS07540	COG0052	Belongs to the universal ribosomal protein uS2 family
K9U01_RS07600	COG1393	Belongs to the ArsC family
K9U01_RS07605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K9U01_RS07615	COG0367	asparagine synthase
K9U01_RS07625	COG4774	siderophore transport
K9U01_RS07665	COG1566	PFAM secretion protein HlyD family protein
K9U01_RS07670	COG2814	Major facilitator Superfamily
K9U01_RS07730	COG0339	signal peptide processing
K9U01_RS07740	COG0386	Belongs to the glutathione peroxidase family
K9U01_RS07800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K9U01_RS07805	COG0084	hydrolase, TatD family'
K9U01_RS07820	COG1960	acyl-CoA dehydrogenase activity
K9U01_RS07835	COG0367	asparagine synthase
K9U01_RS07845	COG0305	Participates in initiation and elongation during chromosome replication
K9U01_RS07850	COG0415	Belongs to the DNA photolyase family
K9U01_RS07865	COG0583	DNA-binding transcription factor activity
K9U01_RS07880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9U01_RS07915	COG3706	GGDEF domain
K9U01_RS07955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K9U01_RS07960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K9U01_RS07975	COG0494	nUDIX hydrolase
K9U01_RS07980	COG0433	COG0433 Predicted ATPase
K9U01_RS07990	COG0688	phosphatidylethanolamine metabolic process
K9U01_RS08000	COG2890	protein-(glutamine-N5) methyltransferase activity
K9U01_RS08015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K9U01_RS08020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K9U01_RS08035	COG0101	tRNA pseudouridine synthase activity
K9U01_RS08050	COG0133	tryptophan synthase activity
K9U01_RS08060	COG0159	tryptophan synthase activity
K9U01_RS08065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K9U01_RS08070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K9U01_RS08100	COG4221	oxidoreductase activity
K9U01_RS08120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9U01_RS08130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9U01_RS08140	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K9U01_RS08145	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K9U01_RS08155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K9U01_RS08160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9U01_RS08165	COG0839	Belongs to the complex I subunit 6 family
K9U01_RS08185	COG1007	ATP synthesis coupled electron transport
K9U01_RS08195	COG0779	Required for maturation of 30S ribosomal subunits
K9U01_RS08200	COG0195	Participates in both transcription termination and antitermination
K9U01_RS08210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K9U01_RS08215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K9U01_RS08220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K9U01_RS08225	COG1185	polyribonucleotide nucleotidyltransferase activity
K9U01_RS08260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K9U01_RS08265	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS08270	COG2095	MarC family integral membrane protein
K9U01_RS08280	COG1611	Belongs to the LOG family
K9U01_RS08285	COG3275	phosphorelay sensor kinase activity
K9U01_RS08330	COG0556	nucleotide-excision repair
K9U01_RS08345	COG3505	Type IV secretory pathway VirD4
K9U01_RS08365	COG2948	multi-organism process
K9U01_RS08385	COG3702	type iv secretory pathway
K9U01_RS08440	COG1082	Xylose isomerase domain protein TIM barrel
K9U01_RS08450	COG2190	(PTS) system
K9U01_RS08450	COG2211	Major facilitator Superfamily
K9U01_RS08465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K9U01_RS08470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K9U01_RS08485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K9U01_RS08490	COG0072	phenylalanine-tRNA ligase activity
K9U01_RS08490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K9U01_RS08540	COG0438	transferase activity, transferring glycosyl groups
K9U01_RS08545	COG0438	transferase activity, transferring glycosyl groups
K9U01_RS08555	COG0438	transferase activity, transferring glycosyl groups
K9U01_RS08580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K9U01_RS08585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K9U01_RS08590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K9U01_RS08610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K9U01_RS08620	COG1960	acyl-CoA dehydrogenase activity
K9U01_RS08650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K9U01_RS08660	COG0784	Response regulator, receiver
K9U01_RS08660	COG4191	Histidine kinase
K9U01_RS08670	COG1194	a g-specific adenine glycosylase
K9U01_RS08675	COG0552	protein localization to endoplasmic reticulum
K9U01_RS08685	COG3938	Belongs to the proline racemase family
K9U01_RS08690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9U01_RS08705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K9U01_RS08715	COG0006	proline dipeptidase activity
K9U01_RS08730	COG0531	amino acid
K9U01_RS08815	COG0326	Molecular chaperone. Has ATPase activity
K9U01_RS08820	COG0742	ribosomal rna small subunit methyltransferase
K9U01_RS08840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K9U01_RS08850	COG3291	Pkd domain containing protein
K9U01_RS08890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K9U01_RS08900	COG1862	Preprotein translocase
K9U01_RS08910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K9U01_RS08920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K9U01_RS08920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K9U01_RS08925	COG1105	Belongs to the carbohydrate kinase PfkB family
K9U01_RS08930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K9U01_RS08930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K9U01_RS08935	COG1609	Transcriptional regulator
K9U01_RS08945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K9U01_RS08950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9U01_RS08960	COG2902	Dehydrogenase
K9U01_RS08970	COG0604	alcohol dehydrogenase
K9U01_RS08970	COG3321	synthase
K9U01_RS09015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K9U01_RS09020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K9U01_RS09025	COG0131	Imidazoleglycerol-phosphate dehydratase
K9U01_RS09025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K9U01_RS09030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K9U01_RS09035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K9U01_RS09045	COG0140	phosphoribosyl-ATP diphosphatase activity
K9U01_RS09045	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K9U01_RS09075	COG0531	amino acid
K9U01_RS09080	COG0531	amino acid
K9U01_RS09090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K9U01_RS09095	COG0277	FAD linked oxidase domain protein
K9U01_RS09115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K9U01_RS09155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K9U01_RS09160	COG2258	MOSC domain
K9U01_RS09170	COG0505	Belongs to the CarA family
K9U01_RS09180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K9U01_RS09185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K9U01_RS09195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K9U01_RS09210	COG3279	Response regulator of the LytR AlgR family
K9U01_RS09220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K9U01_RS09230	COG2205	protein histidine kinase activity
K9U01_RS09230	COG0784	Response regulator, receiver
K9U01_RS09230	COG2198	Histidine kinase
K9U01_RS09235	COG1024	Enoyl-CoA hydratase
K9U01_RS09240	COG0318	PFAM AMP-dependent synthetase and ligase
K9U01_RS09270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K9U01_RS09295	COG0840	transmembrane signaling receptor activity
K9U01_RS09305	COG0835	chemotaxis
K9U01_RS09325	COG0840	transmembrane signaling receptor activity
K9U01_RS09330	COG0840	transmembrane signaling receptor activity
K9U01_RS09335	COG0840	transmembrane signaling receptor activity
K9U01_RS09340	COG0840	transmembrane signaling receptor activity
K9U01_RS09345	COG0840	transmembrane signaling receptor activity
K9U01_RS09350	COG0840	transmembrane signaling receptor activity
K9U01_RS09360	COG0840	transmembrane signaling receptor activity
K9U01_RS09365	COG0840	transmembrane signaling receptor activity
K9U01_RS09375	COG0840	transmembrane signaling receptor activity
K9U01_RS09385	COG0745	RESPONSE REGULATOR receiver
K9U01_RS09395	COG0835	chemotaxis
K9U01_RS09405	COG1360	Flagellar Motor Protein
K9U01_RS09410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K9U01_RS09425	COG0643	Histidine kinase
K9U01_RS09425	COG2198	Histidine kinase
K9U01_RS09425	COG0784	Response regulator, receiver
K9U01_RS09475	COG3300	MHYT domain
K9U01_RS09475	COG5001	Diguanylate cyclase
K9U01_RS09480	COG1684	flagellar biosynthetic protein fliR
K9U01_RS09545	COG1677	Flagellar hook-basal body complex protein FliE
K9U01_RS09575	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS09585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K9U01_RS09605	COG2951	lytic endotransglycosylase activity
K9U01_RS09610	COG4644	lycopene metabolic process
K9U01_RS09690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K9U01_RS09730	COG2201	protein-glutamate methylesterase activity
K9U01_RS09760	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K9U01_RS09765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K9U01_RS09770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K9U01_RS09780	COG1705	Flagellar rod assembly protein muramidase FlgJ
K9U01_RS09780	COG3951	Flagellar rod assembly protein muramidase FlgJ
K9U01_RS09785	COG1706	bacterial-type flagellum-dependent cell motility
K9U01_RS09790	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K9U01_RS09800	COG4787	bacterial-type flagellum-dependent cell motility
K9U01_RS09810	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K9U01_RS09815	COG1558	bacterial-type flagellum-dependent cell motility
K9U01_RS09820	COG1815	bacterial-type flagellum-dependent cell motility
K9U01_RS09825	COG0784	Response regulator, receiver
K9U01_RS09825	COG0835	chemotaxis
K9U01_RS09845	COG4191	Histidine kinase
K9U01_RS09880	COG0482	sulfurtransferase activity
K9U01_RS09895	COG0542	response to heat
K9U01_RS09905	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K9U01_RS09915	COG0492	ferredoxin-NADP+ reductase activity
K9U01_RS09920	COG1674	ftsk spoiiie
K9U01_RS09940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K9U01_RS09945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K9U01_RS09950	COG0183	Belongs to the thiolase family
K9U01_RS09955	COG1024	Enoyl-CoA hydratase
K9U01_RS09955	COG1250	3-hydroxyacyl-CoA dehydrogenase
K9U01_RS09970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K9U01_RS09980	COG1426	Protein conserved in bacteria
K9U01_RS09990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K9U01_RS09995	COG1160	GTP binding
K9U01_RS10000	COG0303	'Molybdopterin
K9U01_RS10005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K9U01_RS10030	COG0708	Exodeoxyribonuclease III
K9U01_RS10040	COG0303	'Molybdopterin
K9U01_RS10045	COG0746	molybdenum cofactor guanylyltransferase activity
K9U01_RS10055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K9U01_RS10055	COG1648	precorrin-2 dehydrogenase activity
K9U01_RS10080	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K9U01_RS10095	COG0579	oxidoreductase
K9U01_RS10115	COG5001	Diguanylate cyclase
K9U01_RS10180	COG0784	Response regulator, receiver
K9U01_RS10180	COG4191	Histidine kinase
K9U01_RS10240	COG0840	transmembrane signaling receptor activity
K9U01_RS10270	COG3781	membrane
K9U01_RS10280	COG2197	response regulator
K9U01_RS10295	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS10555	COG0428	transporter
K9U01_RS10565	COG1530	ribonuclease E activity
K9U01_RS10575	COG1054	Belongs to the UPF0176 family
K9U01_RS10595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K9U01_RS10620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K9U01_RS10625	COG0322	excinuclease ABC activity
K9U01_RS10635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K9U01_RS10640	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K9U01_RS10645	COG1663	tetraacyldisaccharide 4'-kinase activity
K9U01_RS10650	COG1132	(ABC) transporter
K9U01_RS10655	COG0848	biopolymer transport protein
K9U01_RS10660	COG0811	peptide transport
K9U01_RS10675	COG1136	(ABC) transporter
K9U01_RS10680	COG4591	ABC-type transport system involved in lipoprotein release permease component
K9U01_RS10690	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K9U01_RS10695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K9U01_RS10710	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K9U01_RS10715	COG2009	succinate dehydrogenase
K9U01_RS10735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K9U01_RS10740	COG0837	glucose binding
K9U01_RS10750	COG0129	dihydroxy-acid dehydratase activity
K9U01_RS10755	COG0800	Aldolase
K9U01_RS10920	COG0784	Response regulator, receiver
K9U01_RS10920	COG2205	protein histidine kinase activity
K9U01_RS10920	COG5002	protein histidine kinase activity
K9U01_RS10925	COG2183	response to ionizing radiation
K9U01_RS10935	COG0723	plastoquinol--plastocyanin reductase activity
K9U01_RS10935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9U01_RS10950	COG3243	poly(R)-hydroxyalkanoic acid synthase
K9U01_RS10960	COG1183	phosphatidylcholine synthase activity
K9U01_RS10965	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS10990	COG0668	transmembrane transport
K9U01_RS10995	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K9U01_RS11010	COG1914	H( )-stimulated, divalent metal cation uptake system
K9U01_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS11085	COG0582	viral genome integration into host DNA
K9U01_RS11100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K9U01_RS11115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K9U01_RS11130	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K9U01_RS11145	COG0539	negative regulation of cytoplasmic translation
K9U01_RS11150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K9U01_RS11165	COG2957	Belongs to the agmatine deiminase family
K9U01_RS11170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K9U01_RS11195	COG0395	ABC-type sugar transport system, permease component
K9U01_RS11200	COG1175	transmembrane transport
K9U01_RS11220	COG1609	Transcriptional regulator
K9U01_RS11230	COG2350	Protein conserved in bacteria
K9U01_RS11235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K9U01_RS11240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K9U01_RS11245	COG1187	pseudouridine synthase activity
K9U01_RS11265	COG0436	Aminotransferase
K9U01_RS11270	COG4133	protoheme IX ABC transporter activity
K9U01_RS11290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K9U01_RS11315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K9U01_RS11325	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K9U01_RS11330	COG4988	ABC transporter
K9U01_RS11340	COG1294	oxidase, subunit
K9U01_RS11385	COG0165	Argininosuccinate lyase
K9U01_RS11400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K9U01_RS11405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K9U01_RS11410	COG0137	argininosuccinate synthase activity
K9U01_RS11415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K9U01_RS11425	COG0215	cysteine-tRNA ligase activity
K9U01_RS11430	COG2166	iron-sulfur cluster assembly
K9U01_RS11450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K9U01_RS11465	COG4303	Ethanolamine ammonia lyase large subunit
K9U01_RS11470	COG4302	ethanolamine ammonia-lyase activity
K9U01_RS11520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K9U01_RS11525	COG0402	S-adenosylhomocysteine deaminase activity
K9U01_RS11535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K9U01_RS11545	COG5001	Diguanylate cyclase
K9U01_RS11545	COG3300	MHYT domain
K9U01_RS11560	COG0483	inositol monophosphate 1-phosphatase activity
K9U01_RS11565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K9U01_RS11580	COG0488	(ABC) transporter
K9U01_RS11585	COG0513	Belongs to the DEAD box helicase family
K9U01_RS11590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K9U01_RS11595	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K9U01_RS11605	COG0625	glutathione transferase activity
K9U01_RS11620	COG4681	YaeQ
K9U01_RS11640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K9U01_RS11645	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS11665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K9U01_RS11670	COG0860	N-Acetylmuramoyl-L-alanine amidase
K9U01_RS11680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K9U01_RS11680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K9U01_RS11685	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K9U01_RS11700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K9U01_RS11725	COG2199	diguanylate cyclase activity
K9U01_RS11730	COG0835	chemotaxis
K9U01_RS11735	COG0840	transmembrane signaling receptor activity
K9U01_RS11740	COG2094	Belongs to the DNA glycosylase MPG family
K9U01_RS11745	COG1201	RNA secondary structure unwinding
K9U01_RS11755	COG2969	positive regulation of protein catabolic process
K9U01_RS11760	COG0625	glutathione transferase activity
K9U01_RS11765	COG2857	Cytochrome c1
K9U01_RS11770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K9U01_RS11775	COG0723	plastoquinol--plastocyanin reductase activity
K9U01_RS11780	COG0741	lytic transglycosylase activity
K9U01_RS11800	COG1702	phosphate starvation-inducible protein PhoH
K9U01_RS11820	COG4535	Mg2 and Co2 transporter CorC
K9U01_RS11835	COG1012	belongs to the aldehyde dehydrogenase family
K9U01_RS11845	COG1177	transmembrane transport
K9U01_RS11850	COG1176	ABC-type spermidine putrescine transport system, permease component I
K9U01_RS11855	COG3842	ATPase activity
K9U01_RS11875	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K9U01_RS11885	COG0174	glutamine synthetase
K9U01_RS11890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K9U01_RS11895	COG0174	glutamine synthetase
K9U01_RS11900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9U01_RS11925	COG0243	molybdopterin cofactor binding
K9U01_RS11935	COG2223	nitrite transmembrane transporter activity
K9U01_RS11940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K9U01_RS11950	COG2733	membrane
K9U01_RS11955	COG2205	protein histidine kinase activity
K9U01_RS11955	COG0784	Response regulator, receiver
K9U01_RS11955	COG5002	protein histidine kinase activity
K9U01_RS11965	COG0477	Major facilitator Superfamily
K9U01_RS11975	COG0604	alcohol dehydrogenase
K9U01_RS11980	COG0300	oxidoreductase activity
K9U01_RS12015	COG0460	homoserine dehydrogenase
K9U01_RS12015	COG0527	aspartate kinase activity
K9U01_RS12060	COG0726	polysaccharide deacetylase
K9U01_RS12060	COG1649	PFAM Uncharacterised BCR, COG1649
K9U01_RS12065	COG1215	transferase activity, transferring glycosyl groups
K9U01_RS12090	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K9U01_RS12090	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K9U01_RS12155	COG2815	serine threonine protein kinase
K9U01_RS12155	COG0515	serine threonine protein kinase
K9U01_RS12225	COG1012	belongs to the aldehyde dehydrogenase family
K9U01_RS12245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K9U01_RS12265	COG0671	phosphoesterase, PA-phosphatase related
K9U01_RS12270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K9U01_RS12280	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K9U01_RS12285	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K9U01_RS12290	COG2203	Gaf domain
K9U01_RS12290	COG3706	GGDEF domain
K9U01_RS12290	COG5001	Diguanylate cyclase
K9U01_RS12290	COG4251	negative regulation of phosphorylation
K9U01_RS12300	COG1472	Belongs to the glycosyl hydrolase 3 family
K9U01_RS12330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K9U01_RS12335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K9U01_RS12360	COG0860	N-Acetylmuramoyl-L-alanine amidase
K9U01_RS12375	COG0477	Major facilitator Superfamily
K9U01_RS12385	COG1070	Carbohydrate kinase
K9U01_RS12395	COG1501	Belongs to the glycosyl hydrolase 31 family
K9U01_RS12430	COG0800	Aldolase
K9U01_RS12435	COG4948	Mandelate Racemase Muconate Lactonizing
K9U01_RS12445	COG3734	2-keto-3-deoxy-galactonokinase
K9U01_RS12450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K9U01_RS12460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K9U01_RS12475	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K9U01_RS12480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K9U01_RS12520	COG0583	DNA-binding transcription factor activity
K9U01_RS12525	COG1741	Belongs to the pirin family
K9U01_RS12545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K9U01_RS12550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K9U01_RS12555	COG2137	regulation of response to DNA damage stimulus
K9U01_RS12560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K9U01_RS12570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K9U01_RS12575	COG4771	TonB-dependent receptor
K9U01_RS12580	COG1546	Belongs to the CinA family
K9U01_RS12585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K9U01_RS12600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K9U01_RS12610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K9U01_RS12615	COG1534	Rna-binding protein
K9U01_RS12630	COG1238	metal cluster binding
K9U01_RS12635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K9U01_RS12640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K9U01_RS12645	COG2840	Smr protein MutS2
K9U01_RS12655	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K9U01_RS12660	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K9U01_RS12670	COG0148	phosphopyruvate hydratase activity
K9U01_RS12720	COG1253	flavin adenine dinucleotide binding
K9U01_RS12735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K9U01_RS12740	COG0477	Major facilitator Superfamily
K9U01_RS12745	COG1132	(ABC) transporter
K9U01_RS12750	COG1136	(ABC) transporter
K9U01_RS12770	COG0438	transferase activity, transferring glycosyl groups
K9U01_RS12775	COG0438	transferase activity, transferring glycosyl groups
K9U01_RS12780	COG2264	protein methyltransferase activity
K9U01_RS12810	COG2244	polysaccharide biosynthetic process
K9U01_RS12860	COG1595	DNA-templated transcription, initiation
K9U01_RS12870	COG1404	Belongs to the peptidase S8 family
K9U01_RS12875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K9U01_RS12895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K9U01_RS12910	COG4191	Histidine kinase
K9U01_RS12910	COG0784	Response regulator, receiver
K9U01_RS12915	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K9U01_RS12920	COG0784	Response regulator, receiver
K9U01_RS12920	COG4191	Histidine kinase
K9U01_RS12940	COG0840	transmembrane signaling receptor activity
K9U01_RS12955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K9U01_RS12975	COG0840	transmembrane signaling receptor activity
K9U01_RS13000	COG0583	DNA-binding transcription factor activity
K9U01_RS13005	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K9U01_RS13020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K9U01_RS13025	COG0077	Prephenate dehydratase
K9U01_RS13025	COG1605	Chorismate mutase
K9U01_RS13030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K9U01_RS13035	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K9U01_RS13040	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K9U01_RS13075	COG1228	amidohydrolase
K9U01_RS13080	COG2986	histidine ammonia-lyase
K9U01_RS13090	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K9U01_RS13105	COG4993	Dehydrogenase
K9U01_RS13115	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K9U01_RS13130	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K9U01_RS13135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K9U01_RS13140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K9U01_RS13150	COG3115	cell septum assembly
K9U01_RS13175	COG0316	Belongs to the HesB IscA family
K9U01_RS13180	COG0017	Asparaginyl-tRNA synthetase
K9U01_RS13245	COG0288	reversible hydration of carbon dioxide
K9U01_RS13250	COG0662	Cupin 2, conserved barrel domain protein
K9U01_RS13260	COG3844	kynureninase activity
K9U01_RS13265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9U01_RS13270	COG2925	Exonuclease
K9U01_RS13285	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K9U01_RS13295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K9U01_RS13310	COG0488	(ABC) transporter
K9U01_RS13315	COG2264	protein methyltransferase activity
K9U01_RS13350	COG0494	nUDIX hydrolase
K9U01_RS13360	COG1024	Enoyl-CoA hydratase
K9U01_RS13370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K9U01_RS13375	COG0659	secondary active sulfate transmembrane transporter activity
K9U01_RS13400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K9U01_RS13405	COG0573	inorganic phosphate transmembrane transporter activity
K9U01_RS13410	COG0581	inorganic phosphate transmembrane transporter activity
K9U01_RS13415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K9U01_RS13420	COG0704	Plays a role in the regulation of phosphate uptake
K9U01_RS13430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K9U01_RS13445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K9U01_RS13455	COG0557	exoribonuclease II activity
K9U01_RS13470	COG1960	acyl-CoA dehydrogenase activity
K9U01_RS13475	COG2226	methyltransferase
K9U01_RS13480	COG0646	methionine synthase
K9U01_RS13480	COG1410	methionine synthase
K9U01_RS13485	COG0646	methionine synthase
K9U01_RS13485	COG1410	methionine synthase
K9U01_RS13495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K9U01_RS13520	COG2900	Belongs to the SlyX family
K9U01_RS13535	COG0386	Belongs to the glutathione peroxidase family
K9U01_RS13545	COG1725	Transcriptional regulator
K9U01_RS13550	COG1131	(ABC) transporter
K9U01_RS13580	COG1253	flavin adenine dinucleotide binding
K9U01_RS13635	COG1619	proteins homologs of microcin C7 resistance protein MccF
K9U01_RS13645	COG1132	(ABC) transporter
K9U01_RS13650	COG0583	DNA-binding transcription factor activity
K9U01_RS13655	COG2274	protein secretion by the type I secretion system
K9U01_RS13675	COG1605	Chorismate mutase
K9U01_RS13675	COG0287	Prephenate dehydrogenase
K9U01_RS13680	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K9U01_RS13690	COG0443	Heat shock 70 kDa protein
K9U01_RS13695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K9U01_RS13700	COG1420	regulation of RNA biosynthetic process
K9U01_RS13705	COG0497	DNA recombination
K9U01_RS13715	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K9U01_RS13730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K9U01_RS13850	COG0717	Belongs to the dCTP deaminase family
K9U01_RS13855	COG0489	protein tyrosine kinase activity
K9U01_RS13875	COG3590	peptidase
K9U01_RS13880	COG3590	peptidase
K9U01_RS13905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K9U01_RS13910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9U01_RS13915	COG2311	Membrane
K9U01_RS13920	COG1047	Peptidyl-prolyl cis-trans
K9U01_RS13925	COG0791	NLP P60 protein
K9U01_RS13930	COG0791	NLP P60 protein
K9U01_RS13945	COG1301	dicarboxylic acid transport
K9U01_RS13950	COG1785	Belongs to the alkaline phosphatase family
K9U01_RS13955	COG0037	tRNA processing
K9U01_RS13960	COG1722	exodeoxyribonuclease VII activity
K9U01_RS13965	COG0142	geranyltranstransferase activity
K9U01_RS13980	COG0312	modulator of DNA gyrase
K9U01_RS13990	COG0312	modulator of DNA gyrase
K9U01_RS14000	COG3164	Protein of unknown function
K9U01_RS14010	COG0424	maF-like protein
K9U01_RS14015	COG2968	Membrane
K9U01_RS14030	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K9U01_RS14050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K9U01_RS14065	COG0495	leucyl-tRNA aminoacylation
K9U01_RS14075	COG3118	belongs to the thioredoxin family
K9U01_RS14100	COG2155	Conserved Protein
K9U01_RS14150	COG0475	glutathione-regulated potassium exporter activity
K9U01_RS14160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K9U01_RS14180	COG1187	pseudouridine synthase activity
K9U01_RS14185	COG5002	protein histidine kinase activity
K9U01_RS14185	COG5001	Diguanylate cyclase
K9U01_RS14325	COG0667	Aldo Keto reductase
K9U01_RS14330	COG2814	Major facilitator Superfamily
K9U01_RS14335	COG0583	DNA-binding transcription factor activity
K9U01_RS14345	COG2207	Transcriptional regulator
K9U01_RS14370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K9U01_RS14385	COG0735	belongs to the Fur family
K9U01_RS14390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K9U01_RS14415	COG4452	Inner membrane protein CreD
K9U01_RS14435	COG2205	protein histidine kinase activity
K9U01_RS14440	COG0745	RESPONSE REGULATOR receiver
K9U01_RS14445	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K9U01_RS14455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K9U01_RS14465	COG0643	Histidine kinase
K9U01_RS14465	COG2198	Histidine kinase
K9U01_RS14470	COG0840	transmembrane signaling receptor activity
K9U01_RS14475	COG0835	chemotaxis
K9U01_RS14480	COG2202	Pas domain
K9U01_RS14480	COG2200	EAL domain
K9U01_RS14480	COG2199	diguanylate cyclase activity
K9U01_RS14485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K9U01_RS14495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K9U01_RS14500	COG3590	peptidase
K9U01_RS14510	COG0588	phosphoglycerate mutase activity
K9U01_RS14515	COG1515	deoxyribonuclease V activity
K9U01_RS14530	COG1741	Belongs to the pirin family
K9U01_RS14545	COG1741	Belongs to the pirin family
K9U01_RS14550	COG1966	Carbon starvation protein
K9U01_RS14555	COG2879	small protein
K9U01_RS14560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K9U01_RS14600	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K9U01_RS14605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K9U01_RS14610	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K9U01_RS14615	COG2080	2 iron, 2 sulfur cluster binding
K9U01_RS14620	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS14620	COG0604	alcohol dehydrogenase
K9U01_RS14620	COG3321	synthase
K9U01_RS14625	COG5001	Diguanylate cyclase
K9U01_RS14625	COG4251	negative regulation of phosphorylation
K9U01_RS14625	COG3706	GGDEF domain
K9U01_RS14625	COG2203	Gaf domain
K9U01_RS14630	COG0629	single-stranded DNA binding
K9U01_RS14635	COG0142	geranyltranstransferase activity
K9U01_RS14660	COG0527	aspartate kinase activity
K9U01_RS14665	COG0384	phenazine biosynthesis protein PhzF
K9U01_RS14670	COG0384	phenazine biosynthesis protein PhzF
K9U01_RS14680	COG1764	response to oxidative stress
K9U01_RS14685	COG0540	Belongs to the ATCase OTCase family
K9U01_RS14690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K9U01_RS14695	COG1678	Uncharacterized ACR, COG1678
K9U01_RS14700	COG0519	Catalyzes the synthesis of GMP from XMP
K9U01_RS14720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K9U01_RS14735	COG4942	peptidase
K9U01_RS14755	COG0693	protein deglycase activity
K9U01_RS14765	COG1959	2 iron, 2 sulfur cluster binding
K9U01_RS14770	COG0719	Fe-S assembly protein
K9U01_RS14775	COG0396	ATPase activity
K9U01_RS14780	COG0719	Fe-S assembly protein
K9U01_RS14785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K9U01_RS14795	COG2146	nitrite reductase [NAD(P)H] activity
K9U01_RS14800	COG4774	siderophore transport
K9U01_RS14805	COG3128	pkhd-type hydroxylase
K9U01_RS14830	COG1477	protein flavinylation
K9U01_RS14835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K9U01_RS14850	COG1555	photosystem II stabilization
K9U01_RS14855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K9U01_RS14865	COG3178	'Phosphotransferase
K9U01_RS14870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K9U01_RS14880	COG0628	permease
K9U01_RS14900	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K9U01_RS14925	COG0271	Belongs to the BolA IbaG family
K9U01_RS14935	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K9U01_RS14945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K9U01_RS14965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K9U01_RS14985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K9U01_RS14990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K9U01_RS14995	COG2239	Acts as a magnesium transporter
K9U01_RS15005	COG1294	oxidase, subunit
K9U01_RS15010	COG1271	oxidase subunit
K9U01_RS15025	COG1113	amino acid transport
K9U01_RS15040	COG2197	response regulator
K9U01_RS15045	COG0531	amino acid
K9U01_RS15085	COG2814	Major facilitator Superfamily
K9U01_RS15090	COG0754	glutathionylspermidine amidase activity
K9U01_RS15115	COG1842	Phage shock protein A
K9U01_RS15135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K9U01_RS15140	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K9U01_RS15150	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K9U01_RS15155	COG0477	Major facilitator Superfamily
K9U01_RS15165	COG0784	Response regulator, receiver
K9U01_RS15165	COG2198	Histidine kinase
K9U01_RS15165	COG2205	protein histidine kinase activity
K9U01_RS15170	COG2353	YceI-like domain
K9U01_RS15175	COG3038	cytochrome b561
K9U01_RS15190	COG1760	l-serine dehydratase
K9U01_RS15200	COG0527	aspartate kinase activity
K9U01_RS15200	COG0460	homoserine dehydrogenase
K9U01_RS15205	COG0626	cystathionine gamma-synthase activity
K9U01_RS15210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K9U01_RS15215	COG0739	heme binding
K9U01_RS15220	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K9U01_RS15230	COG2982	Protein involved in outer membrane biogenesis
K9U01_RS15235	COG0516	GMP reductase activity
K9U01_RS15235	COG0517	IMP dehydrogenase activity
K9U01_RS15240	COG0463	Glycosyl transferase, family 2
K9U01_RS15245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K9U01_RS15250	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K9U01_RS15260	COG4771	TonB-dependent receptor
K9U01_RS15265	COG1309	transcriptional regulator
K9U01_RS15275	COG1960	acyl-CoA dehydrogenase activity
K9U01_RS15305	COG0509	glycine decarboxylation via glycine cleavage system
K9U01_RS15310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K9U01_RS15320	COG0330	HflC and HflK could
K9U01_RS15325	COG1742	UPF0060 membrane protein
K9U01_RS15330	COG3956	TIGRFAM MazG family protein
K9U01_RS15340	COG0494	nUDIX hydrolase
K9U01_RS15350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K9U01_RS15355	COG0837	glucose binding
K9U01_RS15370	COG1388	LysM domain
K9U01_RS15370	COG3858	chitin binding
K9U01_RS15375	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K9U01_RS15385	COG1472	Belongs to the glycosyl hydrolase 3 family
K9U01_RS15400	COG0531	amino acid
K9U01_RS15410	COG1486	melibiose metabolic process
K9U01_RS15420	COG3537	Alpha-1,2-mannosidase
K9U01_RS15460	COG3645	SOS response
K9U01_RS15480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K9U01_RS15510	COG3142	Participates in the control of copper homeostasis
K9U01_RS15515	COG1446	asparaginase
K9U01_RS15520	COG2304	oxidoreductase activity
K9U01_RS15525	COG1595	DNA-templated transcription, initiation
K9U01_RS15550	COG2198	Histidine kinase
K9U01_RS15550	COG0784	Response regulator, receiver
K9U01_RS15550	COG0643	Histidine kinase
K9U01_RS15555	COG0840	transmembrane signaling receptor activity
K9U01_RS15560	COG0835	chemotaxis
K9U01_RS15575	COG0189	ligase activity
K9U01_RS15585	COG1397	ADP-ribosylglycohydrolase
K9U01_RS15595	COG1199	ATP-dependent helicase activity
K9U01_RS15605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K9U01_RS15610	COG1215	transferase activity, transferring glycosyl groups
K9U01_RS15620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K9U01_RS15630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K9U01_RS15635	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
K9U01_RS15660	COG0837	glucose binding
K9U01_RS15675	COG1643	Atp-dependent helicase
K9U01_RS15680	COG0783	Belongs to the Dps family
K9U01_RS15685	COG0514	ATP-dependent DNA helicase (RecQ)
K9U01_RS15705	COG1187	pseudouridine synthase activity
K9U01_RS15715	COG0840	transmembrane signaling receptor activity
K9U01_RS15735	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K9U01_RS15755	COG0667	Aldo Keto reductase
K9U01_RS15760	COG0602	queuosine metabolic process
K9U01_RS15770	COG2885	chlorophyll binding
K9U01_RS15775	COG0823	Involved in the tonB-independent uptake of proteins
K9U01_RS15785	COG0848	biopolymer transport protein
K9U01_RS15795	COG0824	Thioesterase
K9U01_RS15800	COG2255	four-way junction helicase activity
K9U01_RS15855	COG0477	Major facilitator Superfamily
K9U01_RS15890	COG0488	(ABC) transporter
K9U01_RS15920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K9U01_RS15920	COG4651	solute:proton antiporter activity
K9U01_RS15945	COG4772	TonB-dependent receptor
K9U01_RS15955	COG4264	IucA IucC family
K9U01_RS15960	COG2814	Major facilitator Superfamily
K9U01_RS15965	COG4264	IucA IucC family
K9U01_RS15970	COG0019	diaminopimelate decarboxylase activity
K9U01_RS15995	COG4206	TonB-dependent receptor
K9U01_RS16005	COG0542	response to heat
K9U01_RS16010	COG1116	anion transmembrane transporter activity
K9U01_RS16015	COG1116	anion transmembrane transporter activity
K9U01_RS16020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K9U01_RS16025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K9U01_RS16030	COG0667	Aldo Keto reductase
K9U01_RS16035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K9U01_RS16040	COG4771	TonB-dependent receptor
K9U01_RS16085	COG1877	trehalose-phosphatase activity
K9U01_RS16090	COG3387	PFAM Glycoside hydrolase 15-related
K9U01_RS16105	COG0840	transmembrane signaling receptor activity
K9U01_RS16115	COG1496	oxidoreductase activity
K9U01_RS16120	COG0564	pseudouridine synthase activity
K9U01_RS16125	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K9U01_RS16135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K9U01_RS16135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K9U01_RS16145	COG0045	succinate-CoA ligase (ADP-forming) activity
K9U01_RS16175	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K9U01_RS16195	COG0745	RESPONSE REGULATOR receiver
K9U01_RS16205	COG0189	ligase activity
K9U01_RS16280	COG0270	DNA (cytosine-5-)-methyltransferase activity
K9U01_RS16500	COG5001	Diguanylate cyclase
K9U01_RS16610	COG2801	Transposase and inactivated derivatives
K9U01_RS16650	COG0583	DNA-binding transcription factor activity
K9U01_RS16655	COG1396	sequence-specific DNA binding
K9U01_RS16675	COG0582	viral genome integration into host DNA
K9U01_RS16705	COG0471	metal ion transport
K9U01_RS16705	COG3273	potassium ion transport
K9U01_RS16725	COG1970	mechanosensitive ion channel activity
K9U01_RS16735	COG1609	Transcriptional regulator
K9U01_RS16745	COG3250	beta-galactosidase activity
K9U01_RS16750	COG4948	Mandelate Racemase Muconate Lactonizing
K9U01_RS16760	COG2272	Belongs to the type-B carboxylesterase lipase family
K9U01_RS16765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K9U01_RS16790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K9U01_RS16795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9U01_RS16800	COG0529	Catalyzes the synthesis of activated sulfate
K9U01_RS16800	COG2895	sulfate adenylyltransferase (ATP) activity
K9U01_RS16810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K9U01_RS16815	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K9U01_RS16820	COG0175	sulfate reduction
K9U01_RS16840	COG2198	Histidine kinase
K9U01_RS16840	COG0784	Response regulator, receiver
K9U01_RS16840	COG2205	protein histidine kinase activity
K9U01_RS16855	COG1648	precorrin-2 dehydrogenase activity
K9U01_RS16855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K9U01_RS16870	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K9U01_RS16875	COG3588	fructose-bisphosphate aldolase
K9U01_RS16880	COG0469	pyruvate kinase activity
K9U01_RS16910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K9U01_RS16925	COG3047	cAMP biosynthetic process
K9U01_RS16935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K9U01_RS16935	COG3453	Protein conserved in bacteria
K9U01_RS16940	COG0725	ABC transporter, periplasmic molybdate-binding protein
K9U01_RS16945	COG4149	molybdate abc transporter
K9U01_RS16950	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K9U01_RS16995	COG1376	ErfK ybiS ycfS ynhG family protein
K9U01_RS17000	COG0739	heme binding
K9U01_RS17005	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS17010	COG0583	DNA-binding transcription factor activity
K9U01_RS17015	COG4773	Receptor
K9U01_RS17020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K9U01_RS17025	COG1301	dicarboxylic acid transport
K9U01_RS17055	COG0714	Associated with various cellular activities
K9U01_RS17085	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K9U01_RS17110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K9U01_RS17120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K9U01_RS17135	COG1561	YicC-like family, N-terminal region
K9U01_RS17140	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K9U01_RS17155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K9U01_RS17170	COG0006	proline dipeptidase activity
K9U01_RS17180	COG0006	proline dipeptidase activity
K9U01_RS17205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K9U01_RS17225	COG2912	Transglutaminase-like superfamily
K9U01_RS17235	COG1773	rubredoxin
K9U01_RS17240	COG0352	thiamine-phosphate diphosphorylase activity
K9U01_RS17250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K9U01_RS17265	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K9U01_RS17270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K9U01_RS17300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K9U01_RS17320	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS17330	COG0671	phosphoesterase, PA-phosphatase related
K9U01_RS17335	COG3781	membrane
K9U01_RS17345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K9U01_RS17350	COG0563	adenylate kinase activity
K9U01_RS17365	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K9U01_RS17375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K9U01_RS17395	COG3710	Transcriptional regulator
K9U01_RS17400	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K9U01_RS17410	COG0823	Involved in the tonB-independent uptake of proteins
K9U01_RS17410	COG1506	peptidase
K9U01_RS17410	COG4946	Tricorn protease homolog
K9U01_RS17420	COG0405	Gamma-glutamyltransferase
K9U01_RS17425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K9U01_RS17445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K9U01_RS17450	COG0473	3-isopropylmalate dehydrogenase activity
K9U01_RS17465	COG0066	3-isopropylmalate dehydratase activity
K9U01_RS17470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K9U01_RS17490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K9U01_RS17495	COG1538	Outer membrane efflux protein
K9U01_RS17500	COG1519	Transferase
K9U01_RS17505	COG1560	Kdo2-lipid A biosynthetic process
K9U01_RS17530	COG0280	phosphate acetyltransferase
K9U01_RS17530	COG0281	malic enzyme
K9U01_RS17545	COG4191	Histidine kinase
K9U01_RS17560	COG0583	DNA-binding transcription factor activity
K9U01_RS17570	COG0667	Aldo Keto reductase
K9U01_RS17575	COG2197	response regulator
K9U01_RS17585	COG0642	Histidine kinase
K9U01_RS17600	COG2851	Citrate transporter
K9U01_RS17605	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS17610	COG1609	Transcriptional regulator
K9U01_RS17615	COG2211	Major facilitator Superfamily
K9U01_RS17665	COG2801	Transposase and inactivated derivatives
K9U01_RS17720	COG4773	Receptor
K9U01_RS17725	COG0726	polysaccharide deacetylase
K9U01_RS17730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K9U01_RS17745	COG3964	amidohydrolase
K9U01_RS17750	COG1228	amidohydrolase
K9U01_RS17795	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K9U01_RS17800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K9U01_RS17825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K9U01_RS17825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K9U01_RS17840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K9U01_RS17850	COG0488	(ABC) transporter
K9U01_RS17855	COG0242	peptide deformylase activity
K9U01_RS17920	COG2188	Transcriptional regulator
K9U01_RS17930	COG1450	Type ii and iii secretion system protein
K9U01_RS17945	COG3166	PFAM Fimbrial assembly family protein
K9U01_RS17950	COG3156	type II secretion system protein K
K9U01_RS17955	COG4795	General secretion pathway protein
K9U01_RS17960	COG2165	general secretion pathway protein
K9U01_RS17965	COG4970	Tfp pilus assembly protein FimT
K9U01_RS17970	COG2165	general secretion pathway protein
K9U01_RS17975	COG1459	type II secretion system
K9U01_RS17980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K9U01_RS17985	COG1404	Belongs to the peptidase S8 family
K9U01_RS17995	COG1404	Belongs to the peptidase S8 family
K9U01_RS18000	COG5295	Hep Hag repeat protein
K9U01_RS18005	COG0047	phosphoribosylformylglycinamidine synthase activity
K9U01_RS18005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K9U01_RS18010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K9U01_RS18015	COG4974	Belongs to the 'phage' integrase family
K9U01_RS18025	COG0795	lipopolysaccharide-transporting ATPase activity
K9U01_RS18045	COG0525	valine-tRNA ligase activity
K9U01_RS18070	COG1183	phosphatidylcholine synthase activity
K9U01_RS18080	COG0442	prolyl-tRNA aminoacylation
K9U01_RS18095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K9U01_RS18100	COG1127	ABC transporter
K9U01_RS18105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K9U01_RS18105	COG3218	ABC-type transport auxiliary lipoprotein component
K9U01_RS18135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K9U01_RS18140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K9U01_RS18145	COG0662	Cupin 2, conserved barrel domain protein
K9U01_RS18145	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K9U01_RS18170	COG2086	electron transfer activity
K9U01_RS18185	COG0546	phosphoglycolate phosphatase activity
K9U01_RS18185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K9U01_RS18190	COG0277	FAD linked oxidase domain protein
K9U01_RS18195	COG0300	oxidoreductase activity
K9U01_RS18200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K9U01_RS18240	COG0438	transferase activity, transferring glycosyl groups
K9U01_RS18240	COG1216	Glycosyl transferase, family 2
K9U01_RS18260	COG0626	cystathionine gamma-synthase activity
K9U01_RS18290	COG0625	glutathione transferase activity
K9U01_RS18300	COG0513	Belongs to the DEAD box helicase family
K9U01_RS18315	COG4771	TonB-dependent receptor
K9U01_RS18320	COG0720	synthase
K9U01_RS18330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K9U01_RS18335	COG1956	GAF domain-containing protein
K9U01_RS18345	COG2819	hydrolase of the alpha beta superfamily
K9U01_RS18355	COG0546	phosphoglycolate phosphatase activity
K9U01_RS18360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K9U01_RS18375	COG0339	signal peptide processing
K9U01_RS18420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K9U01_RS18425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9U01_RS18430	COG1136	(ABC) transporter
K9U01_RS18455	COG4191	Histidine kinase
K9U01_RS18465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K9U01_RS18480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K9U01_RS18500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K9U01_RS18505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K9U01_RS18515	COG0356	it plays a direct role in the translocation of protons across the membrane
K9U01_RS18540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K9U01_RS18550	COG0508	dehydrogenase complex catalyzes the overall conversion of
K9U01_RS18585	COG2011	ABC-type metal ion transport system permease component
K9U01_RS18590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K9U01_RS18595	COG0697	spore germination
K9U01_RS18600	COG1666	GTP binding
K9U01_RS18630	COG1187	pseudouridine synthase activity
K9U01_RS18655	COG2202	Pas domain
K9U01_RS18655	COG2205	protein histidine kinase activity
K9U01_RS18675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K9U01_RS18680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9U01_RS18730	COG0842	Transport permease protein
K9U01_RS18735	COG1131	(ABC) transporter
K9U01_RS18740	COG0025	NhaP-type Na H and K H
K9U01_RS18750	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K9U01_RS18755	COG1573	uracil-dna glycosylase
K9U01_RS18765	COG3384	dioxygenase
K9U01_RS18775	COG0583	DNA-binding transcription factor activity
K9U01_RS18785	COG0667	Aldo Keto reductase
K9U01_RS18795	COG3590	peptidase
K9U01_RS18810	COG0531	amino acid
K9U01_RS18825	COG2972	Histidine kinase
K9U01_RS18845	COG3685	Protein conserved in bacteria
K9U01_RS18850	COG3546	catalase activity
K9U01_RS18875	COG2204	response regulator
K9U01_RS18885	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS18910	COG1063	alcohol dehydrogenase
K9U01_RS18935	COG0583	DNA-binding transcription factor activity
K9U01_RS18940	COG2814	Major facilitator Superfamily
K9U01_RS18980	COG1131	(ABC) transporter
K9U01_RS19000	COG0251	oxidation-reduction process
K9U01_RS19015	COG0840	transmembrane signaling receptor activity
K9U01_RS19050	COG0659	secondary active sulfate transmembrane transporter activity
K9U01_RS19055	COG0038	chloride channel
K9U01_RS19110	COG0642	Histidine kinase
K9U01_RS19120	COG4695	Portal protein
K9U01_RS19165	COG3179	chitinase
K9U01_RS19185	COG4191	Histidine kinase
K9U01_RS19185	COG0784	Response regulator, receiver
K9U01_RS19220	COG0456	acetyltransferase
K9U01_RS19370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K9U01_RS19375	COG1490	D-aminoacyl-tRNA deacylase activity
K9U01_RS19380	COG1560	Kdo2-lipid A biosynthetic process
K9U01_RS19390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K9U01_RS19405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K9U01_RS19425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K9U01_RS19425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K9U01_RS19435	COG0242	peptide deformylase activity
K9U01_RS19440	COG1652	LysM domain
K9U01_RS19445	COG0758	DNA mediated transformation
K9U01_RS19465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K9U01_RS19465	COG1754	DNA topoisomerase type I activity
K9U01_RS19470	COG0009	L-threonylcarbamoyladenylate synthase
K9U01_RS19485	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS19495	COG0616	signal peptide processing
K9U01_RS19500	COG0534	Mate efflux family protein
K9U01_RS19515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K9U01_RS19520	COG0625	glutathione transferase activity
K9U01_RS19535	COG1252	NADH dehydrogenase
K9U01_RS19540	COG2860	membrane
K9U01_RS19545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K9U01_RS19550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K9U01_RS19555	COG2201	protein-glutamate methylesterase activity
K9U01_RS19560	COG2177	Part of the ABC transporter FtsEX involved in
K9U01_RS19565	COG2884	Cell division ATP-binding protein ftsE
K9U01_RS19575	COG3118	belongs to the thioredoxin family
K9U01_RS19580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K9U01_RS19590	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
K9U01_RS19610	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K9U01_RS19610	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K9U01_RS19615	COG1473	amidohydrolase
K9U01_RS19625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K9U01_RS19635	COG5383	Protein conserved in bacteria
K9U01_RS19675	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K9U01_RS19680	COG3023	N-Acetylmuramoyl-L-alanine amidase
K9U01_RS19690	COG4948	Mandelate Racemase Muconate Lactonizing
K9U01_RS19700	COG0531	amino acid
K9U01_RS19715	COG4682	membrane
K9U01_RS19720	COG2133	pyrroloquinoline quinone binding
K9U01_RS19730	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K9U01_RS19745	COG1610	YqeY-like protein
K9U01_RS19750	COG1295	ribonuclease BN
K9U01_RS19755	COG0358	DNA primase activity
K9U01_RS19775	COG0109	protoheme IX farnesyltransferase activity
K9U01_RS19805	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K9U01_RS19820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K9U01_RS19865	COG0739	heme binding
K9U01_RS19880	COG2211	Major facilitator Superfamily
K9U01_RS19885	COG0708	Exodeoxyribonuclease III
K9U01_RS19900	COG1192	Involved in chromosome partitioning
K9U01_RS19905	COG1475	DNA binding
K9U01_RS19925	COG0463	Glycosyl transferase, family 2
K9U01_RS19950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K9U01_RS19960	COG0018	arginyl-trna synthetase
K9U01_RS19975	COG4221	oxidoreductase activity
K9U01_RS19980	COG2755	lipolytic protein G-D-S-L family
K9U01_RS19980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K9U01_RS19990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9U01_RS19990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9U01_RS19995	COG1166	arginine decarboxylase activity
K9U01_RS20000	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K9U01_RS20030	COG2960	long-chain fatty acid transporting porin activity
K9U01_RS20060	COG0210	DNA helicase
K9U01_RS20110	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K9U01_RS20160	COG1090	epimerase
K9U01_RS20170	COG0642	Histidine kinase
K9U01_RS20210	COG0628	permease
K9U01_RS20215	COG1011	Hydrolase
K9U01_RS20220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K9U01_RS20250	COG2197	response regulator
K9U01_RS20255	COG4585	Histidine kinase
K9U01_RS20260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9U01_RS20265	COG1136	(ABC) transporter
K9U01_RS20290	COG0697	spore germination
K9U01_RS20305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K9U01_RS20310	COG0180	Tryptophanyl-tRNA synthetase
K9U01_RS20315	COG3237	CsbD-like
K9U01_RS20355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K9U01_RS20370	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K9U01_RS20375	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K9U01_RS20375	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K9U01_RS20415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K9U01_RS20440	COG1199	ATP-dependent helicase activity
K9U01_RS20500	COG0625	glutathione transferase activity
K9U01_RS20535	COG4555	ABC transporter
K9U01_RS20545	COG1476	TRANSCRIPTIONal
K9U01_RS20580	COG1131	(ABC) transporter
K9U01_RS20585	COG0842	Transport permease protein
K9U01_RS20590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K9U01_RS20600	COG1607	acyl-coa hydrolase
K9U01_RS20615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K9U01_RS20620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K9U01_RS20630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K9U01_RS20630	COG1042	CoA-binding domain protein
K9U01_RS20630	COG0045	succinate-CoA ligase (ADP-forming) activity
K9U01_RS20635	COG2239	Acts as a magnesium transporter
K9U01_RS20645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K9U01_RS20650	COG3387	PFAM Glycoside hydrolase 15-related
K9U01_RS20665	COG3100	YcgL domain-containing protein
K9U01_RS20670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K9U01_RS20695	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS20725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K9U01_RS20740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K9U01_RS20825	COG0210	DNA helicase
K9U01_RS20835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K9U01_RS20840	COG0583	DNA-binding transcription factor activity
K9U01_RS20845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K9U01_RS20855	COG2159	amidohydrolase
K9U01_RS20875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9U01_RS20895	COG0357	Ribosomal RNA small subunit methyltransferase G
K9U01_RS20900	COG3540	Alkaline phosphatase
K9U01_RS20910	COG2091	lysine biosynthetic process via aminoadipic acid
K9U01_RS20930	COG1940	carbohydrate kinase activity
K9U01_RS20940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K9U01_RS20950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K9U01_RS20995	COG3507	Belongs to the glycosyl hydrolase 43 family
K9U01_RS21010	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS21015	COG0179	Fumarylacetoacetate (FAA) hydrolase
K9U01_RS21020	COG4948	Mandelate Racemase Muconate Lactonizing
K9U01_RS21025	COG3254	rhamnose metabolic process
K9U01_RS21030	COG0738	Major facilitator superfamily
K9U01_RS21035	COG1414	Transcriptional regulator
K9U01_RS21040	COG1971	Probably functions as a manganese efflux pump
K9U01_RS21045	COG2205	protein histidine kinase activity
K9U01_RS21045	COG0784	Response regulator, receiver
K9U01_RS21050	COG3459	Glycosyltransferase 36 associated
K9U01_RS21055	COG2211	Major facilitator Superfamily
K9U01_RS21060	COG3265	gluconokinase activity
K9U01_RS21065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K9U01_RS21085	COG2911	Protein conserved in bacteria
K9U01_RS21090	COG0729	surface antigen
K9U01_RS21095	COG4771	TonB-dependent receptor
K9U01_RS21100	COG0457	Tetratricopeptide repeat
K9U01_RS21115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K9U01_RS21120	COG0519	Catalyzes the synthesis of GMP from XMP
K9U01_RS21120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K9U01_RS21130	COG0805	protein transport
K9U01_RS21135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K9U01_RS21140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K9U01_RS21150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K9U01_RS21165	COG2974	May be involved in recombination
K9U01_RS21170	COG0037	tRNA processing
K9U01_RS21185	COG3661	Belongs to the glycosyl hydrolase 67 family
K9U01_RS21195	COG4948	Mandelate Racemase Muconate Lactonizing
K9U01_RS21205	COG1472	Belongs to the glycosyl hydrolase 3 family
K9U01_RS21210	COG0246	Mannitol dehydrogenase
K9U01_RS21235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K9U01_RS21265	COG3250	beta-galactosidase activity
K9U01_RS21270	COG1904	glucuronate isomerase
K9U01_RS21290	COG2211	Major facilitator Superfamily
K9U01_RS21340	COG3321	synthase
K9U01_RS21340	COG1028	Short-chain dehydrogenase reductase Sdr
K9U01_RS21340	COG0604	alcohol dehydrogenase
K9U01_RS21345	COG2937	Belongs to the GPAT DAPAT family
K9U01_RS21375	COG0284	orotidine-5'-phosphate decarboxylase activity
K9U01_RS21380	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
K9U01_RS21385	COG3132	Protein of unknown function, DUF480
K9U01_RS21400	COG0210	DNA helicase
K9U01_RS21405	COG1435	thymidine kinase activity
K9U01_RS21415	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K9U01_RS21425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K9U01_RS21455	COG3135	benzoate transporter
K9U01_RS21480	COG0676	glucose-6-phosphate 1-epimerase activity
K9U01_RS21505	COG0730	response to heat
K9U01_RS21530	COG0302	gtp cyclohydrolase
K9U01_RS21545	COG1566	PFAM secretion protein HlyD family protein
K9U01_RS21555	COG1289	transmembrane transporter activity
K9U01_RS21560	COG0477	Major facilitator Superfamily
K9U01_RS21570	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
K9U01_RS21575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K9U01_RS21640	COG0564	pseudouridine synthase activity
K9U01_RS21670	COG3549	Plasmid maintenance system killer
K9U01_RS21675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K9U01_RS21680	COG1074	ATP-dependent DNA helicase activity
K9U01_RS21685	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K9U01_RS21720	COG1127	ABC transporter
K9U01_RS21725	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K9U01_RS21730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K9U01_RS21745	COG2853	Lipoprotein
K9U01_RS21755	COG0386	Belongs to the glutathione peroxidase family
K9U01_RS21765	COG1322	Protein conserved in bacteria
K9U01_RS21775	COG0531	amino acid
K9U01_RS21780	COG3537	Alpha-1,2-mannosidase
K9U01_RS21795	COG3706	GGDEF domain
K9U01_RS21805	COG1929	Belongs to the glycerate kinase type-1 family
K9U01_RS21810	COG2271	Major facilitator Superfamily
K9U01_RS21860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K9U01_RS21865	COG0861	Integral membrane protein TerC family
K9U01_RS21875	COG0584	glycerophosphoryl diester phosphodiesterase
K9U01_RS21885	COG0671	phosphoesterase, PA-phosphatase related
K9U01_RS21890	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K9U01_RS21895	COG0726	polysaccharide deacetylase
K9U01_RS21900	COG0706	membrane insertase activity
K9U01_RS21925	COG1192	Involved in chromosome partitioning
K9U01_RS21980	COG2951	lytic endotransglycosylase activity
K9U01_RS21985	COG4644	lycopene metabolic process
K9U01_RS22065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K9U01_RS22135	COG1674	ftsk spoiiie
K9U01_RS22160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K9U01_RS22280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K9U01_RS22295	COG4305	rare lipoprotein A
K9U01_RS22315	COG4771	TonB-dependent receptor