locus-tag	class	description
L1B16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L1B16_RS00020	COG0187	DNA topoisomerase II activity
L1B16_RS00030	COG0501	Belongs to the peptidase M48B family
L1B16_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L1B16_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1B16_RS00105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L1B16_RS00110	COG0793	Belongs to the peptidase S41A family
L1B16_RS00115	COG4942	peptidase
L1B16_RS00125	COG2234	aminopeptidase activity
L1B16_RS00135	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L1B16_RS00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L1B16_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L1B16_RS00150	COG1064	alcohol dehydrogenase
L1B16_RS00160	COG0493	'glutamate synthase
L1B16_RS00165	COG0067	glutamate synthase
L1B16_RS00165	COG0069	glutamate synthase activity
L1B16_RS00165	COG0070	glutamate synthase
L1B16_RS00200	COG3459	Glycosyltransferase 36 associated
L1B16_RS00250	COG1111	helicase
L1B16_RS00250	COG1205	dead DEAH box helicase
L1B16_RS00255	COG1272	protein, Hemolysin III
L1B16_RS00295	COG0583	DNA-binding transcription factor activity
L1B16_RS00300	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS00315	COG1733	regulation of RNA biosynthetic process
L1B16_RS00345	COG3237	CsbD-like
L1B16_RS00380	COG0657	acetylesterase activity
L1B16_RS00390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1B16_RS00435	COG1309	transcriptional regulator
L1B16_RS00460	COG4772	TonB-dependent receptor
L1B16_RS00470	COG2423	ornithine cyclodeaminase activity
L1B16_RS00480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1B16_RS00485	COG0765	amino acid transport
L1B16_RS00495	COG3284	Transcriptional regulator
L1B16_RS00500	COG1012	belongs to the aldehyde dehydrogenase family
L1B16_RS00530	COG1304	FMN binding
L1B16_RS00535	COG1755	Isoprenylcysteine carboxyl methyltransferase
L1B16_RS00540	COG4585	Histidine kinase
L1B16_RS00565	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L1B16_RS00645	COG1595	DNA-templated transcription, initiation
L1B16_RS00685	COG0366	Alpha amylase catalytic
L1B16_RS00690	COG0366	Alpha amylase catalytic
L1B16_RS00695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L1B16_RS00740	COG2755	lipolytic protein G-D-S-L family
L1B16_RS00740	COG0657	acetylesterase activity
L1B16_RS00750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L1B16_RS00765	COG3507	Belongs to the glycosyl hydrolase 43 family
L1B16_RS00770	COG1609	Transcriptional regulator
L1B16_RS00775	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
L1B16_RS00780	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS00790	COG2755	lipolytic protein G-D-S-L family
L1B16_RS00800	COG3186	Phenylalanine-4-hydroxylase
L1B16_RS00805	COG1522	sequence-specific DNA binding
L1B16_RS00815	COG1752	Esterase of the alpha-beta hydrolase superfamily
L1B16_RS00825	COG1119	ATPase activity
L1B16_RS00840	COG1125	glycine betaine transport
L1B16_RS00840	COG0517	IMP dehydrogenase activity
L1B16_RS00855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L1B16_RS00860	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
L1B16_RS00890	COG0489	protein tyrosine kinase activity
L1B16_RS00895	COG2062	phosphohistidine phosphatase, SixA
L1B16_RS00900	COG2353	YceI-like domain
L1B16_RS00905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1B16_RS00930	COG1881	PFAM PEBP family protein
L1B16_RS00945	COG0174	glutamine synthetase
L1B16_RS00950	COG0347	Belongs to the P(II) protein family
L1B16_RS00955	COG0004	ammonium transporteR
L1B16_RS00960	COG3852	Histidine kinase
L1B16_RS00965	COG2204	response regulator
L1B16_RS00970	COG2032	superoxide dismutase activity
L1B16_RS00975	COG2032	superoxide dismutase activity
L1B16_RS00990	COG0183	Belongs to the thiolase family
L1B16_RS01030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L1B16_RS01040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L1B16_RS01050	COG0028	Belongs to the TPP enzyme family
L1B16_RS01055	COG2205	protein histidine kinase activity
L1B16_RS01080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L1B16_RS01095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1B16_RS01100	COG3177	Filamentation induced by cAMP protein fic
L1B16_RS01115	COG0596	Alpha beta hydrolase
L1B16_RS01120	COG0727	PFAM Uncharacterised protein family (UPF0153)
L1B16_RS01125	COG0318	PFAM AMP-dependent synthetase and ligase
L1B16_RS01130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1B16_RS01145	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1B16_RS01165	COG0564	pseudouridine synthase activity
L1B16_RS01185	COG1446	asparaginase
L1B16_RS01190	COG0339	signal peptide processing
L1B16_RS01195	COG0681	Belongs to the peptidase S26 family
L1B16_RS01220	COG0475	glutathione-regulated potassium exporter activity
L1B16_RS01225	COG0583	DNA-binding transcription factor activity
L1B16_RS01230	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L1B16_RS01235	COG2224	Isocitrate lyase
L1B16_RS01265	COG4770	biotin carboxylase activity
L1B16_RS01270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L1B16_RS01275	COG1960	acyl-CoA dehydrogenase activity
L1B16_RS01330	COG0523	cobalamin synthesis protein
L1B16_RS01340	COG0697	spore germination
L1B16_RS01350	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L1B16_RS01355	COG1846	Transcriptional regulator
L1B16_RS01360	COG1764	response to oxidative stress
L1B16_RS01385	COG0656	L-ascorbic acid biosynthetic process
L1B16_RS01390	COG2130	NADP-dependent
L1B16_RS01405	COG1187	pseudouridine synthase activity
L1B16_RS01415	COG1643	Atp-dependent helicase
L1B16_RS01420	COG0840	transmembrane signaling receptor activity
L1B16_RS01425	COG4807	Protein conserved in bacteria
L1B16_RS01430	COG2351	hydroxyisourate hydrolase activity
L1B16_RS01435	COG2072	flavoprotein involved in K transport
L1B16_RS01455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L1B16_RS01505	COG1957	nucleoside hydrolase
L1B16_RS01530	COG0084	hydrolase, TatD family'
L1B16_RS01545	COG0583	DNA-binding transcription factor activity
L1B16_RS01550	COG2814	Major facilitator Superfamily
L1B16_RS01555	COG1404	Belongs to the peptidase S8 family
L1B16_RS01575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L1B16_RS01580	COG1902	pentaerythritol trinitrate reductase activity
L1B16_RS01600	COG2223	nitrite transmembrane transporter activity
L1B16_RS01605	COG0745	RESPONSE REGULATOR receiver
L1B16_RS01620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_RS01640	COG0577	efflux transmembrane transporter activity
L1B16_RS01645	COG1136	(ABC) transporter
L1B16_RS01645	COG0577	efflux transmembrane transporter activity
L1B16_RS01695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L1B16_RS01700	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L1B16_RS01705	COG0583	DNA-binding transcription factor activity
L1B16_RS01730	COG0702	epimerase
L1B16_RS01735	COG1733	regulation of RNA biosynthetic process
L1B16_RS01745	COG0840	transmembrane signaling receptor activity
L1B16_RS01790	COG0129	dihydroxy-acid dehydratase activity
L1B16_RS01810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L1B16_RS01865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L1B16_RS01895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L1B16_RS01900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L1B16_RS01910	COG3485	protocatechuate 3,4-dioxygenase
L1B16_RS01915	COG3485	protocatechuate 3,4-dioxygenase
L1B16_RS01925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1B16_RS01930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1B16_RS01940	COG1414	Transcriptional regulator
L1B16_RS01960	COG0445	tRNA wobble uridine modification
L1B16_RS01970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L1B16_RS02010	COG0156	8-amino-7-oxononanoate synthase activity
L1B16_RS02015	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L1B16_RS02020	COG1040	competence protein
L1B16_RS02025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L1B16_RS02090	COG4771	TonB-dependent receptor
L1B16_RS02115	COG1169	isochorismate synthase
L1B16_RS02145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L1B16_RS02145	COG2226	methyltransferase
L1B16_RS02145	COG3433	isochorismatase activity
L1B16_RS02160	COG4771	TonB-dependent receptor
L1B16_RS02165	COG1132	(ABC) transporter
L1B16_RS02165	COG2375	cellular response to nickel ion
L1B16_RS02170	COG1132	(ABC) transporter
L1B16_RS02195	COG1511	domain protein
L1B16_RS02195	COG3264	Mechanosensitive ion channel
L1B16_RS02200	COG1368	sulfuric ester hydrolase activity
L1B16_RS02205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L1B16_RS02210	COG2354	Protein conserved in bacteria
L1B16_RS02220	COG0297	glycogen (starch) synthase activity
L1B16_RS02225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L1B16_RS02230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L1B16_RS02255	COG0702	epimerase
L1B16_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS02300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1B16_RS02305	COG4221	oxidoreductase activity
L1B16_RS02320	COG0513	Belongs to the DEAD box helicase family
L1B16_RS02330	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1B16_RS02345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L1B16_RS02360	COG3104	oligopeptide transport
L1B16_RS02380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
L1B16_RS02395	COG1320	monovalent cation:proton antiporter activity
L1B16_RS02400	COG2212	antiporter activity
L1B16_RS02410	COG0651	ATP synthesis coupled electron transport
L1B16_RS02415	COG1006	Multisubunit Na H antiporter MnhC subunit
L1B16_RS02420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L1B16_RS02420	COG2111	Na H antiporter
L1B16_RS02465	COG0484	heat shock protein binding
L1B16_RS02485	COG1597	lipid kinase activity
L1B16_RS02505	COG0583	DNA-binding transcription factor activity
L1B16_RS02510	COG0583	DNA-binding transcription factor activity
L1B16_RS02515	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
L1B16_RS02525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1B16_RS02610	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L1B16_RS02690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L1B16_RS02695	COG0134	indole-3-glycerol-phosphate synthase activity
L1B16_RS02705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L1B16_RS02720	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
L1B16_RS02730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L1B16_RS02745	COG1051	belongs to the nudix hydrolase family
L1B16_RS02785	COG0316	Belongs to the HesB IscA family
L1B16_RS02800	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L1B16_RS02825	COG2814	Major facilitator Superfamily
L1B16_RS02830	COG1289	transmembrane transporter activity
L1B16_RS02835	COG0151	Belongs to the GarS family
L1B16_RS02840	COG0138	bifunctional purine biosynthesis protein purh
L1B16_RS02860	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L1B16_RS02880	COG2264	protein methyltransferase activity
L1B16_RS02895	COG0439	Biotin carboxylase
L1B16_RS02905	COG0511	ligase activity, forming carbon-carbon bonds
L1B16_RS02910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L1B16_RS02925	COG1324	tolerance protein
L1B16_RS02930	COG2356	endonuclease I
L1B16_RS02960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L1B16_RS02985	COG3712	iron ion homeostasis
L1B16_RS03010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L1B16_RS03040	COG2353	YceI-like domain
L1B16_RS03060	COG3052	prosthetic group binding
L1B16_RS03095	COG1802	Transcriptional regulator
L1B16_RS03100	COG0546	phosphoglycolate phosphatase activity
L1B16_RS03195	COG1595	DNA-templated transcription, initiation
L1B16_RS03210	COG4206	TonB-dependent receptor
L1B16_RS03215	COG0823	Involved in the tonB-independent uptake of proteins
L1B16_RS03215	COG1506	peptidase
L1B16_RS03270	COG0435	Glutathione S-transferase
L1B16_RS03305	COG1506	peptidase
L1B16_RS03305	COG0823	Involved in the tonB-independent uptake of proteins
L1B16_RS03355	COG0697	spore germination
L1B16_RS03375	COG1113	amino acid transport
L1B16_RS03435	COG0840	transmembrane signaling receptor activity
L1B16_RS03440	COG5297	Belongs to the glycosyl hydrolase family 6
L1B16_RS03440	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L1B16_RS03445	COG0659	secondary active sulfate transmembrane transporter activity
L1B16_RS03460	COG2943	transferase activity, transferring hexosyl groups
L1B16_RS03480	COG0181	hydroxymethylbilane synthase activity
L1B16_RS03505	COG1505	serine-type exopeptidase activity
L1B16_RS03510	COG0436	Aminotransferase
L1B16_RS03520	COG2832	Protein of unknown function (DUF454)
L1B16_RS03530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L1B16_RS03545	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
L1B16_RS03575	COG2226	methyltransferase
L1B16_RS03580	COG5001	Diguanylate cyclase
L1B16_RS03580	COG3300	MHYT domain
L1B16_RS03585	COG0308	aminopeptidase N
L1B16_RS03620	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L1B16_RS03630	COG3284	Transcriptional regulator
L1B16_RS03635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1B16_RS03640	COG1077	Cell shape determining protein MreB Mrl
L1B16_RS03650	COG1792	Involved in formation and maintenance of cell shape
L1B16_RS03665	COG0772	Belongs to the SEDS family
L1B16_RS03675	COG2951	lytic endotransglycosylase activity
L1B16_RS03680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L1B16_RS03685	COG1686	Belongs to the peptidase S11 family
L1B16_RS03695	COG2921	Belongs to the UPF0250 family
L1B16_RS03700	COG0321	lipoyl(octanoyl) transferase activity
L1B16_RS03705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L1B16_RS03720	COG0583	DNA-binding transcription factor activity
L1B16_RS03730	COG1051	belongs to the nudix hydrolase family
L1B16_RS03730	COG1056	cytidyltransferase-related domain
L1B16_RS03745	COG2813	Specifically methylates the guanine in position
L1B16_RS03765	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L1B16_RS03770	COG0673	inositol 2-dehydrogenase activity
L1B16_RS03775	COG2823	Periplasmic or secreted lipoprotein
L1B16_RS03780	COG4251	negative regulation of phosphorylation
L1B16_RS03785	COG0784	Response regulator, receiver
L1B16_RS03790	COG4191	Histidine kinase
L1B16_RS03795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L1B16_RS03800	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS03845	COG1459	type II secretion system
L1B16_RS03895	COG3250	beta-galactosidase activity
L1B16_RS03910	COG2188	Transcriptional regulator
L1B16_RS03920	COG1609	Transcriptional regulator
L1B16_RS03925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1B16_RS03930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L1B16_RS03945	COG0617	tRNA 3'-terminal CCA addition
L1B16_RS03960	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
L1B16_RS03965	COG1012	belongs to the aldehyde dehydrogenase family
L1B16_RS03970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L1B16_RS03980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L1B16_RS03995	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L1B16_RS04000	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L1B16_RS04015	COG2205	protein histidine kinase activity
L1B16_RS04035	COG3920	Histidine kinase
L1B16_RS04050	COG3791	Glutathione-dependent formaldehyde-activating
L1B16_RS04060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1B16_RS04070	COG0697	spore germination
L1B16_RS04090	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L1B16_RS04095	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L1B16_RS04100	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
L1B16_RS04105	COG2205	protein histidine kinase activity
L1B16_RS04110	COG0745	RESPONSE REGULATOR receiver
L1B16_RS04115	COG0823	Involved in the tonB-independent uptake of proteins
L1B16_RS04115	COG1506	peptidase
L1B16_RS04115	COG4946	Tricorn protease homolog
L1B16_RS04120	COG0277	FAD linked oxidase domain protein
L1B16_RS04125	COG1988	membrane-bound metal-dependent
L1B16_RS04130	COG0792	nuclease activity
L1B16_RS04165	COG3116	cell division
L1B16_RS04175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L1B16_RS04180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L1B16_RS04200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L1B16_RS04205	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1B16_RS04210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L1B16_RS04235	COG0739	heme binding
L1B16_RS04240	COG0653	protein targeting
L1B16_RS04250	COG0494	nUDIX hydrolase
L1B16_RS04265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L1B16_RS04270	COG3321	synthase
L1B16_RS04270	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS04270	COG0604	alcohol dehydrogenase
L1B16_RS04290	COG0366	Alpha amylase catalytic
L1B16_RS04315	COG2226	methyltransferase
L1B16_RS04330	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L1B16_RS04360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L1B16_RS04375	COG4106	trans-aconitate 2-methyltransferase activity
L1B16_RS04380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L1B16_RS04390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L1B16_RS04395	COG0667	Aldo Keto reductase
L1B16_RS04405	COG4771	TonB-dependent receptor
L1B16_RS04425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1B16_RS04430	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L1B16_RS04440	COG2175	clavaminate synthase activity
L1B16_RS04450	COG4181	ATPase activity
L1B16_RS04465	COG0642	Histidine kinase
L1B16_RS04475	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L1B16_RS04495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L1B16_RS04500	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L1B16_RS04510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L1B16_RS04515	COG2967	ApaG domain
L1B16_RS04520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L1B16_RS04525	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L1B16_RS04535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L1B16_RS04540	COG0123	including yeast histone deacetylase and acetoin utilization protein
L1B16_RS04545	COG2096	Adenosyltransferase
L1B16_RS04555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1B16_RS04560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1B16_RS04590	COG3384	dioxygenase
L1B16_RS04595	COG0583	DNA-binding transcription factor activity
L1B16_RS04600	COG0318	PFAM AMP-dependent synthetase and ligase
L1B16_RS04610	COG1024	Enoyl-CoA hydratase
L1B16_RS04660	COG0697	spore germination
L1B16_RS04665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L1B16_RS04690	COG2197	response regulator
L1B16_RS04700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L1B16_RS04710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L1B16_RS04715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1B16_RS04720	COG0583	DNA-binding transcription factor activity
L1B16_RS04725	COG3634	alkyl hydroperoxide reductase activity
L1B16_RS04735	COG2890	protein-(glutamine-N5) methyltransferase activity
L1B16_RS04755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L1B16_RS04755	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L1B16_RS04785	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L1B16_RS04830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L1B16_RS04835	COG1404	Belongs to the peptidase S8 family
L1B16_RS04840	COG1404	Belongs to the peptidase S8 family
L1B16_RS04845	COG1404	Belongs to the peptidase S8 family
L1B16_RS04850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L1B16_RS04870	COG1295	ribonuclease BN
L1B16_RS04875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1B16_RS04880	COG1254	Belongs to the acylphosphatase family
L1B16_RS04895	COG0521	Mo-molybdopterin cofactor biosynthetic process
L1B16_RS04905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L1B16_RS04910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L1B16_RS04920	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L1B16_RS04935	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L1B16_RS04940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L1B16_RS04945	COG0193	aminoacyl-tRNA hydrolase activity
L1B16_RS04950	COG0012	GTP binding
L1B16_RS04970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L1B16_RS04980	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L1B16_RS04985	COG0250	Participates in transcription elongation, termination and antitermination
L1B16_RS04990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L1B16_RS04995	COG0081	regulation of translation
L1B16_RS05000	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L1B16_RS05005	COG0222	ribosome binding
L1B16_RS05015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L1B16_RS05020	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L1B16_RS05030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L1B16_RS05035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L1B16_RS05040	COG0051	transcription antitermination factor activity, RNA binding
L1B16_RS05060	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L1B16_RS05070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L1B16_RS05085	COG0255	Belongs to the universal ribosomal protein uL29 family
L1B16_RS05100	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L1B16_RS05120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L1B16_RS05135	COG1841	ribosomal large subunit assembly
L1B16_RS05145	COG0201	protein transport
L1B16_RS05170	COG0203	ribosomal protein L17
L1B16_RS05180	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L1B16_RS05190	COG0154	amidase activity
L1B16_RS05200	COG1217	gtp-binding protein TYPA
L1B16_RS05205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L1B16_RS05215	COG0625	glutathione transferase activity
L1B16_RS05230	COG1902	pentaerythritol trinitrate reductase activity
L1B16_RS05230	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1B16_RS05235	COG0604	alcohol dehydrogenase
L1B16_RS05240	COG2885	chlorophyll binding
L1B16_RS05265	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L1B16_RS05270	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L1B16_RS05275	COG4208	sulfate ABC transporter
L1B16_RS05280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L1B16_RS05310	COG0406	alpha-ribazole phosphatase activity
L1B16_RS05320	COG0285	dihydrofolate synthase activity
L1B16_RS05340	COG2833	Protein of unknown function (DUF455)
L1B16_RS05345	COG3291	Pkd domain containing protein
L1B16_RS05355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1B16_RS05360	COG0671	phosphoesterase, PA-phosphatase related
L1B16_RS05365	COG0438	transferase activity, transferring glycosyl groups
L1B16_RS05375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L1B16_RS05390	COG4783	chaperone-mediated protein folding
L1B16_RS05405	COG0473	3-isopropylmalate dehydrogenase activity
L1B16_RS05440	COG0784	Response regulator, receiver
L1B16_RS05440	COG4191	Histidine kinase
L1B16_RS05450	COG0544	peptidyl-prolyl cis-trans isomerase activity
L1B16_RS05460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L1B16_RS05490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L1B16_RS05500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1B16_RS05520	COG0631	protein serine/threonine phosphatase activity
L1B16_RS05535	COG0859	PFAM glycosyl transferase family 9
L1B16_RS05545	COG1234	tRNA 3'-trailer cleavage
L1B16_RS05550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L1B16_RS05555	COG0315	cyclic pyranopterin monophosphate synthase activity
L1B16_RS05560	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
L1B16_RS05565	COG0314	molybdopterin synthase activity
L1B16_RS05585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L1B16_RS05590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L1B16_RS05595	COG0537	adenosine 5'-monophosphoramidase activity
L1B16_RS05615	COG0714	Associated with various cellular activities
L1B16_RS05635	COG0424	maF-like protein
L1B16_RS05640	COG1399	metal-binding, possibly nucleic acid-binding protein
L1B16_RS05645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L1B16_RS05650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1B16_RS05660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L1B16_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS05680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L1B16_RS05685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L1B16_RS05710	COG3829	transcription factor binding
L1B16_RS05730	COG3609	addiction module antidote protein, CC2985 family
L1B16_RS05785	COG4953	penicillin-binding protein 1C
L1B16_RS05795	COG0678	peroxiredoxin activity
L1B16_RS05815	COG0330	HflC and HflK could
L1B16_RS05820	COG0330	HflC and HflK could
L1B16_RS05835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L1B16_RS05840	COG0308	aminopeptidase N
L1B16_RS05860	COG1309	transcriptional regulator
L1B16_RS05905	COG1309	transcriptional regulator
L1B16_RS05915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L1B16_RS05925	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS05935	COG3537	Alpha-1,2-mannosidase
L1B16_RS05975	COG2323	membrane
L1B16_RS05990	COG2271	Major facilitator Superfamily
L1B16_RS06015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1B16_RS06020	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L1B16_RS06025	COG2080	2 iron, 2 sulfur cluster binding
L1B16_RS06085	COG0587	DNA-directed DNA polymerase activity
L1B16_RS06095	COG1297	OPT oligopeptide transporter protein
L1B16_RS06115	COG1506	peptidase
L1B16_RS06115	COG0823	Involved in the tonB-independent uptake of proteins
L1B16_RS06130	COG1917	Cupin 2, conserved barrel domain protein
L1B16_RS06130	COG2207	Transcriptional regulator
L1B16_RS06135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_RS06170	COG0753	catalase activity
L1B16_RS06175	COG0656	L-ascorbic acid biosynthetic process
L1B16_RS06180	COG2272	Belongs to the type-B carboxylesterase lipase family
L1B16_RS06185	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L1B16_RS06185	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L1B16_RS06215	COG2194	sulfuric ester hydrolase activity
L1B16_RS06225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L1B16_RS06230	COG0745	RESPONSE REGULATOR receiver
L1B16_RS06235	COG5002	protein histidine kinase activity
L1B16_RS06250	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
L1B16_RS06255	COG2894	cell division
L1B16_RS06270	COG4585	Histidine kinase
L1B16_RS06275	COG2197	response regulator
L1B16_RS06290	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L1B16_RS06325	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
L1B16_RS06335	COG1595	DNA-templated transcription, initiation
L1B16_RS06345	COG1946	Acyl-CoA thioesterase
L1B16_RS06350	COG1024	Enoyl-CoA hydratase
L1B16_RS06360	COG0824	Thioesterase
L1B16_RS06365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L1B16_RS06375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L1B16_RS06380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L1B16_RS06390	COG0728	peptidoglycan biosynthetic process
L1B16_RS06395	COG0196	riboflavin kinase activity
L1B16_RS06405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L1B16_RS06410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L1B16_RS06425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L1B16_RS06430	COG1845	cytochrome c oxidase, subunit III
L1B16_RS06435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L1B16_RS06450	COG3152	Membrane
L1B16_RS06460	COG2207	Transcriptional regulator
L1B16_RS06465	COG0326	Molecular chaperone. Has ATPase activity
L1B16_RS06475	COG1902	pentaerythritol trinitrate reductase activity
L1B16_RS06480	COG1366	Belongs to the anti-sigma-factor antagonist family
L1B16_RS06485	COG1366	Belongs to the anti-sigma-factor antagonist family
L1B16_RS06490	COG2172	sigma factor antagonist activity
L1B16_RS06520	COG4771	TonB-dependent receptor
L1B16_RS06530	COG5507	3-demethylubiquinone-9 3-methyltransferase
L1B16_RS06535	COG2205	protein histidine kinase activity
L1B16_RS06545	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L1B16_RS06550	COG3437	response regulator, receiver
L1B16_RS06550	COG2205	protein histidine kinase activity
L1B16_RS06550	COG4999	Histidine kinase
L1B16_RS06550	COG3850	Histidine kinase
L1B16_RS06555	COG4191	Histidine kinase
L1B16_RS06555	COG0784	Response regulator, receiver
L1B16_RS06605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L1B16_RS06610	COG2070	2-Nitropropane dioxygenase
L1B16_RS06630	COG0336	Belongs to the RNA methyltransferase TrmD family
L1B16_RS06660	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L1B16_RS06670	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L1B16_RS06720	COG3209	COG3209 Rhs family protein
L1B16_RS06790	COG0840	transmembrane signaling receptor activity
L1B16_RS06815	COG2814	Major facilitator Superfamily
L1B16_RS06835	COG2003	Belongs to the UPF0758 family
L1B16_RS06855	COG0322	excinuclease ABC activity
L1B16_RS06895	COG3250	beta-galactosidase activity
L1B16_RS06900	COG3867	Arabinogalactan endo-beta-1,4-galactanase
L1B16_RS06910	COG1396	sequence-specific DNA binding
L1B16_RS06910	COG3800	Transcriptional regulator
L1B16_RS06920	COG1960	acyl-CoA dehydrogenase activity
L1B16_RS06945	COG1024	Enoyl-CoA hydratase
L1B16_RS06945	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1B16_RS06960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1B16_RS06965	COG0481	GTPase activity
L1B16_RS06980	COG0571	ribonuclease III activity
L1B16_RS06985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L1B16_RS06990	COG1381	Involved in DNA repair and RecF pathway recombination
L1B16_RS07005	COG2954	triphosphatase activity
L1B16_RS07010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L1B16_RS07015	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
L1B16_RS07020	COG3046	protein related to deoxyribodipyrimidine photolyase
L1B16_RS07025	COG1472	Belongs to the glycosyl hydrolase 3 family
L1B16_RS07030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L1B16_RS07035	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L1B16_RS07040	COG1278	Cold shock
L1B16_RS07045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1B16_RS07055	COG1201	RNA secondary structure unwinding
L1B16_RS07060	COG1793	dna ligase
L1B16_RS07070	COG1793	dna ligase
L1B16_RS07070	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L1B16_RS07100	COG0183	Belongs to the thiolase family
L1B16_RS07120	COG1451	nucleotide metabolic process
L1B16_RS07125	COG5487	UPF0391 membrane protein
L1B16_RS07135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L1B16_RS07180	COG1047	Peptidyl-prolyl cis-trans
L1B16_RS07190	COG2824	Alkylphosphonate utilization operon protein PhnA
L1B16_RS07210	COG1902	pentaerythritol trinitrate reductase activity
L1B16_RS07215	COG2814	Major facilitator Superfamily
L1B16_RS07255	COG0392	lysyltransferase activity
L1B16_RS07255	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L1B16_RS07265	COG0251	oxidation-reduction process
L1B16_RS07270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L1B16_RS07285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L1B16_RS07310	COG1595	DNA-templated transcription, initiation
L1B16_RS07325	COG2878	Part of a membrane complex involved in electron transport
L1B16_RS07335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1B16_RS07335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1B16_RS07355	COG0346	lactoylglutathione lyase activity
L1B16_RS07375	COG0833	amino acid
L1B16_RS07380	COG2040	homocysteine
L1B16_RS07400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
L1B16_RS07420	COG1695	Transcriptional regulator
L1B16_RS07440	COG1981	membrane
L1B16_RS07450	COG0825	malonyl-CoA metabolic process
L1B16_RS07465	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1B16_RS07470	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1B16_RS07480	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1B16_RS07495	COG0750	zinc metalloprotease
L1B16_RS07500	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L1B16_RS07505	COG0575	Belongs to the CDS family
L1B16_RS07515	COG0233	cytoplasmic translational termination
L1B16_RS07520	COG0528	UMP kinase activity
L1B16_RS07530	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L1B16_RS07535	COG0052	Belongs to the universal ribosomal protein uS2 family
L1B16_RS07595	COG1393	Belongs to the ArsC family
L1B16_RS07600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1B16_RS07610	COG0367	asparagine synthase
L1B16_RS07620	COG4774	siderophore transport
L1B16_RS07660	COG1566	PFAM secretion protein HlyD family protein
L1B16_RS07665	COG2814	Major facilitator Superfamily
L1B16_RS07725	COG0339	signal peptide processing
L1B16_RS07735	COG0386	Belongs to the glutathione peroxidase family
L1B16_RS07795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L1B16_RS07800	COG0084	hydrolase, TatD family'
L1B16_RS07815	COG1960	acyl-CoA dehydrogenase activity
L1B16_RS07830	COG0367	asparagine synthase
L1B16_RS07840	COG0305	Participates in initiation and elongation during chromosome replication
L1B16_RS07845	COG0415	Belongs to the DNA photolyase family
L1B16_RS07860	COG0583	DNA-binding transcription factor activity
L1B16_RS07875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_RS07910	COG3706	GGDEF domain
L1B16_RS07950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L1B16_RS07955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1B16_RS07970	COG0494	nUDIX hydrolase
L1B16_RS07975	COG0433	COG0433 Predicted ATPase
L1B16_RS07985	COG0688	phosphatidylethanolamine metabolic process
L1B16_RS07995	COG2890	protein-(glutamine-N5) methyltransferase activity
L1B16_RS08010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L1B16_RS08015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L1B16_RS08030	COG0101	tRNA pseudouridine synthase activity
L1B16_RS08045	COG0133	tryptophan synthase activity
L1B16_RS08055	COG0159	tryptophan synthase activity
L1B16_RS08060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L1B16_RS08065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1B16_RS08095	COG4221	oxidoreductase activity
L1B16_RS08115	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L1B16_RS08125	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L1B16_RS08135	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
L1B16_RS08140	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L1B16_RS08150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L1B16_RS08155	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L1B16_RS08160	COG0839	Belongs to the complex I subunit 6 family
L1B16_RS08180	COG1007	ATP synthesis coupled electron transport
L1B16_RS08190	COG0779	Required for maturation of 30S ribosomal subunits
L1B16_RS08195	COG0195	Participates in both transcription termination and antitermination
L1B16_RS08205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L1B16_RS08210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L1B16_RS08215	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L1B16_RS08220	COG1185	polyribonucleotide nucleotidyltransferase activity
L1B16_RS08255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L1B16_RS08260	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS08265	COG2095	MarC family integral membrane protein
L1B16_RS08275	COG1611	Belongs to the LOG family
L1B16_RS08280	COG3275	phosphorelay sensor kinase activity
L1B16_RS08325	COG0556	nucleotide-excision repair
L1B16_RS08340	COG3505	Type IV secretory pathway VirD4
L1B16_RS08360	COG2948	multi-organism process
L1B16_RS08380	COG3702	type iv secretory pathway
L1B16_RS08455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L1B16_RS08500	COG1082	Xylose isomerase domain protein TIM barrel
L1B16_RS08510	COG2190	(PTS) system
L1B16_RS08510	COG2211	Major facilitator Superfamily
L1B16_RS08525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L1B16_RS08530	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L1B16_RS08545	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L1B16_RS08550	COG0072	phenylalanine-tRNA ligase activity
L1B16_RS08550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1B16_RS08600	COG0438	transferase activity, transferring glycosyl groups
L1B16_RS08605	COG0438	transferase activity, transferring glycosyl groups
L1B16_RS08615	COG0438	transferase activity, transferring glycosyl groups
L1B16_RS08640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1B16_RS08645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1B16_RS08650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1B16_RS08670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L1B16_RS08680	COG1960	acyl-CoA dehydrogenase activity
L1B16_RS08710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L1B16_RS08720	COG4191	Histidine kinase
L1B16_RS08720	COG0784	Response regulator, receiver
L1B16_RS08730	COG1194	a g-specific adenine glycosylase
L1B16_RS08735	COG0552	protein localization to endoplasmic reticulum
L1B16_RS08745	COG3938	Belongs to the proline racemase family
L1B16_RS08750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1B16_RS08765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1B16_RS08775	COG0006	proline dipeptidase activity
L1B16_RS08790	COG0531	amino acid
L1B16_RS08870	COG0326	Molecular chaperone. Has ATPase activity
L1B16_RS08875	COG0742	ribosomal rna small subunit methyltransferase
L1B16_RS08895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L1B16_RS08905	COG3291	Pkd domain containing protein
L1B16_RS08945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L1B16_RS08955	COG1862	Preprotein translocase
L1B16_RS08965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L1B16_RS08975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1B16_RS08975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1B16_RS08980	COG1105	Belongs to the carbohydrate kinase PfkB family
L1B16_RS08985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1B16_RS08985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L1B16_RS08990	COG1609	Transcriptional regulator
L1B16_RS09000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1B16_RS09005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_RS09015	COG2902	Dehydrogenase
L1B16_RS09025	COG3321	synthase
L1B16_RS09025	COG0604	alcohol dehydrogenase
L1B16_RS09040	COG0300	oxidoreductase activity
L1B16_RS09045	COG0604	alcohol dehydrogenase
L1B16_RS09055	COG0477	Major facilitator Superfamily
L1B16_RS09065	COG0784	Response regulator, receiver
L1B16_RS09065	COG2205	protein histidine kinase activity
L1B16_RS09065	COG5002	protein histidine kinase activity
L1B16_RS09070	COG2733	membrane
L1B16_RS09080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L1B16_RS09085	COG2223	nitrite transmembrane transporter activity
L1B16_RS09095	COG0243	molybdopterin cofactor binding
L1B16_RS09105	COG0477	Major facilitator Superfamily
L1B16_RS09110	COG2703	oxygen carrier activity
L1B16_RS09120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1B16_RS09125	COG0174	glutamine synthetase
L1B16_RS09130	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L1B16_RS09135	COG0174	glutamine synthetase
L1B16_RS09145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L1B16_RS09165	COG3842	ATPase activity
L1B16_RS09170	COG1176	ABC-type spermidine putrescine transport system, permease component I
L1B16_RS09175	COG1177	transmembrane transport
L1B16_RS09185	COG1012	belongs to the aldehyde dehydrogenase family
L1B16_RS09200	COG4535	Mg2 and Co2 transporter CorC
L1B16_RS09220	COG1702	phosphate starvation-inducible protein PhoH
L1B16_RS09240	COG0741	lytic transglycosylase activity
L1B16_RS09245	COG0723	plastoquinol--plastocyanin reductase activity
L1B16_RS09250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L1B16_RS09255	COG2857	Cytochrome c1
L1B16_RS09260	COG0625	glutathione transferase activity
L1B16_RS09265	COG2969	positive regulation of protein catabolic process
L1B16_RS09275	COG1201	RNA secondary structure unwinding
L1B16_RS09280	COG2094	Belongs to the DNA glycosylase MPG family
L1B16_RS09285	COG0840	transmembrane signaling receptor activity
L1B16_RS09290	COG0835	chemotaxis
L1B16_RS09295	COG2199	diguanylate cyclase activity
L1B16_RS09320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L1B16_RS09335	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L1B16_RS09340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L1B16_RS09340	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L1B16_RS09350	COG0860	N-Acetylmuramoyl-L-alanine amidase
L1B16_RS09355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L1B16_RS09375	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS09380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L1B16_RS09400	COG4681	YaeQ
L1B16_RS09415	COG0625	glutathione transferase activity
L1B16_RS09425	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L1B16_RS09430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L1B16_RS09435	COG0513	Belongs to the DEAD box helicase family
L1B16_RS09440	COG0488	(ABC) transporter
L1B16_RS09455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L1B16_RS09460	COG0483	inositol monophosphate 1-phosphatase activity
L1B16_RS09475	COG3300	MHYT domain
L1B16_RS09475	COG5001	Diguanylate cyclase
L1B16_RS09485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L1B16_RS09495	COG0402	S-adenosylhomocysteine deaminase activity
L1B16_RS09500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L1B16_RS09550	COG4302	ethanolamine ammonia-lyase activity
L1B16_RS09555	COG4303	Ethanolamine ammonia lyase large subunit
L1B16_RS09570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L1B16_RS09590	COG2166	iron-sulfur cluster assembly
L1B16_RS09595	COG0215	cysteine-tRNA ligase activity
L1B16_RS09605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L1B16_RS09610	COG0137	argininosuccinate synthase activity
L1B16_RS09615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1B16_RS09620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L1B16_RS09635	COG0165	Argininosuccinate lyase
L1B16_RS09680	COG1294	oxidase, subunit
L1B16_RS09690	COG4988	ABC transporter
L1B16_RS09695	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L1B16_RS09705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1B16_RS09730	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
L1B16_RS09750	COG4133	protoheme IX ABC transporter activity
L1B16_RS09755	COG0436	Aminotransferase
L1B16_RS09775	COG1187	pseudouridine synthase activity
L1B16_RS09780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L1B16_RS09785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L1B16_RS09790	COG2350	Protein conserved in bacteria
L1B16_RS09800	COG1609	Transcriptional regulator
L1B16_RS09820	COG1175	transmembrane transport
L1B16_RS09825	COG0395	ABC-type sugar transport system, permease component
L1B16_RS09850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1B16_RS09855	COG2957	Belongs to the agmatine deiminase family
L1B16_RS09870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L1B16_RS09875	COG0539	negative regulation of cytoplasmic translation
L1B16_RS09890	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
L1B16_RS09905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L1B16_RS09920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L1B16_RS09935	COG0582	viral genome integration into host DNA
L1B16_RS09985	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS10010	COG1914	H( )-stimulated, divalent metal cation uptake system
L1B16_RS10025	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L1B16_RS10030	COG0668	transmembrane transport
L1B16_RS10055	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS10060	COG1183	phosphatidylcholine synthase activity
L1B16_RS10070	COG3243	poly(R)-hydroxyalkanoic acid synthase
L1B16_RS10085	COG0723	plastoquinol--plastocyanin reductase activity
L1B16_RS10085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1B16_RS10095	COG2183	response to ionizing radiation
L1B16_RS10100	COG2205	protein histidine kinase activity
L1B16_RS10100	COG5002	protein histidine kinase activity
L1B16_RS10100	COG0784	Response regulator, receiver
L1B16_RS10265	COG0800	Aldolase
L1B16_RS10270	COG0129	dihydroxy-acid dehydratase activity
L1B16_RS10280	COG0837	glucose binding
L1B16_RS10285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L1B16_RS10305	COG2009	succinate dehydrogenase
L1B16_RS10310	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L1B16_RS10325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L1B16_RS10330	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L1B16_RS10340	COG4591	ABC-type transport system involved in lipoprotein release permease component
L1B16_RS10345	COG1136	(ABC) transporter
L1B16_RS10360	COG0811	peptide transport
L1B16_RS10365	COG0848	biopolymer transport protein
L1B16_RS10370	COG1132	(ABC) transporter
L1B16_RS10375	COG1663	tetraacyldisaccharide 4'-kinase activity
L1B16_RS10380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L1B16_RS10385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L1B16_RS10395	COG0322	excinuclease ABC activity
L1B16_RS10400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L1B16_RS10425	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L1B16_RS10445	COG1054	Belongs to the UPF0176 family
L1B16_RS10455	COG1530	ribonuclease E activity
L1B16_RS10465	COG0428	transporter
L1B16_RS10720	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS10735	COG2197	response regulator
L1B16_RS10745	COG3781	membrane
L1B16_RS10775	COG0840	transmembrane signaling receptor activity
L1B16_RS10835	COG4191	Histidine kinase
L1B16_RS10835	COG0784	Response regulator, receiver
L1B16_RS10895	COG5001	Diguanylate cyclase
L1B16_RS10915	COG0579	oxidoreductase
L1B16_RS10930	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
L1B16_RS10955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L1B16_RS10955	COG1648	precorrin-2 dehydrogenase activity
L1B16_RS10965	COG0746	molybdenum cofactor guanylyltransferase activity
L1B16_RS10970	COG0303	'Molybdopterin
L1B16_RS10980	COG0708	Exodeoxyribonuclease III
L1B16_RS11005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L1B16_RS11010	COG0303	'Molybdopterin
L1B16_RS11015	COG1160	GTP binding
L1B16_RS11020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L1B16_RS11030	COG1426	Protein conserved in bacteria
L1B16_RS11040	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L1B16_RS11055	COG1024	Enoyl-CoA hydratase
L1B16_RS11055	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1B16_RS11060	COG0183	Belongs to the thiolase family
L1B16_RS11065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L1B16_RS11070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L1B16_RS11090	COG1674	ftsk spoiiie
L1B16_RS11095	COG0492	ferredoxin-NADP+ reductase activity
L1B16_RS11105	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L1B16_RS11115	COG0542	response to heat
L1B16_RS11130	COG0482	sulfurtransferase activity
L1B16_RS11165	COG4191	Histidine kinase
L1B16_RS11185	COG0784	Response regulator, receiver
L1B16_RS11185	COG0835	chemotaxis
L1B16_RS11190	COG1815	bacterial-type flagellum-dependent cell motility
L1B16_RS11195	COG1558	bacterial-type flagellum-dependent cell motility
L1B16_RS11200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
L1B16_RS11210	COG4787	bacterial-type flagellum-dependent cell motility
L1B16_RS11220	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
L1B16_RS11225	COG1706	bacterial-type flagellum-dependent cell motility
L1B16_RS11230	COG1705	Flagellar rod assembly protein muramidase FlgJ
L1B16_RS11230	COG3951	Flagellar rod assembly protein muramidase FlgJ
L1B16_RS11240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L1B16_RS11245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L1B16_RS11250	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
L1B16_RS11280	COG2201	protein-glutamate methylesterase activity
L1B16_RS11320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L1B16_RS11400	COG4644	lycopene metabolic process
L1B16_RS11405	COG2951	lytic endotransglycosylase activity
L1B16_RS11425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1B16_RS11435	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS11465	COG1677	Flagellar hook-basal body complex protein FliE
L1B16_RS11530	COG1684	flagellar biosynthetic protein fliR
L1B16_RS11535	COG5001	Diguanylate cyclase
L1B16_RS11535	COG3300	MHYT domain
L1B16_RS11585	COG0784	Response regulator, receiver
L1B16_RS11585	COG2198	Histidine kinase
L1B16_RS11585	COG0643	Histidine kinase
L1B16_RS11600	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L1B16_RS11605	COG1360	Flagellar Motor Protein
L1B16_RS11615	COG0835	chemotaxis
L1B16_RS11625	COG0745	RESPONSE REGULATOR receiver
L1B16_RS11635	COG0840	transmembrane signaling receptor activity
L1B16_RS11645	COG0840	transmembrane signaling receptor activity
L1B16_RS11650	COG0840	transmembrane signaling receptor activity
L1B16_RS11660	COG0840	transmembrane signaling receptor activity
L1B16_RS11665	COG0840	transmembrane signaling receptor activity
L1B16_RS11670	COG0840	transmembrane signaling receptor activity
L1B16_RS11675	COG0840	transmembrane signaling receptor activity
L1B16_RS11680	COG0840	transmembrane signaling receptor activity
L1B16_RS11685	COG0840	transmembrane signaling receptor activity
L1B16_RS11705	COG0835	chemotaxis
L1B16_RS11715	COG0840	transmembrane signaling receptor activity
L1B16_RS11740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1B16_RS11770	COG0318	PFAM AMP-dependent synthetase and ligase
L1B16_RS11775	COG1024	Enoyl-CoA hydratase
L1B16_RS11780	COG0784	Response regulator, receiver
L1B16_RS11780	COG2198	Histidine kinase
L1B16_RS11780	COG2205	protein histidine kinase activity
L1B16_RS11790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L1B16_RS11800	COG3279	Response regulator of the LytR AlgR family
L1B16_RS11815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L1B16_RS11825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1B16_RS11830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L1B16_RS11840	COG0505	Belongs to the CarA family
L1B16_RS11850	COG2258	MOSC domain
L1B16_RS11855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1B16_RS11895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L1B16_RS11915	COG0277	FAD linked oxidase domain protein
L1B16_RS11920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1B16_RS11930	COG0531	amino acid
L1B16_RS11935	COG0531	amino acid
L1B16_RS11965	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L1B16_RS11965	COG0140	phosphoribosyl-ATP diphosphatase activity
L1B16_RS11975	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L1B16_RS11980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L1B16_RS11985	COG0131	Imidazoleglycerol-phosphate dehydratase
L1B16_RS11985	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L1B16_RS11990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L1B16_RS11995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L1B16_RS12015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L1B16_RS12040	COG0460	homoserine dehydrogenase
L1B16_RS12040	COG0527	aspartate kinase activity
L1B16_RS12085	COG1649	PFAM Uncharacterised BCR, COG1649
L1B16_RS12085	COG0726	polysaccharide deacetylase
L1B16_RS12090	COG1215	transferase activity, transferring glycosyl groups
L1B16_RS12115	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L1B16_RS12115	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L1B16_RS12180	COG0515	serine threonine protein kinase
L1B16_RS12180	COG2815	serine threonine protein kinase
L1B16_RS12250	COG1012	belongs to the aldehyde dehydrogenase family
L1B16_RS12270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L1B16_RS12290	COG0671	phosphoesterase, PA-phosphatase related
L1B16_RS12295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L1B16_RS12305	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
L1B16_RS12310	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L1B16_RS12315	COG2203	Gaf domain
L1B16_RS12315	COG5001	Diguanylate cyclase
L1B16_RS12315	COG4251	negative regulation of phosphorylation
L1B16_RS12315	COG3706	GGDEF domain
L1B16_RS12325	COG1472	Belongs to the glycosyl hydrolase 3 family
L1B16_RS12355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L1B16_RS12360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L1B16_RS12385	COG0860	N-Acetylmuramoyl-L-alanine amidase
L1B16_RS12400	COG0477	Major facilitator Superfamily
L1B16_RS12410	COG1070	Carbohydrate kinase
L1B16_RS12420	COG1501	Belongs to the glycosyl hydrolase 31 family
L1B16_RS12455	COG0800	Aldolase
L1B16_RS12460	COG4948	Mandelate Racemase Muconate Lactonizing
L1B16_RS12470	COG3734	2-keto-3-deoxy-galactonokinase
L1B16_RS12475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L1B16_RS12485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1B16_RS12500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L1B16_RS12505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L1B16_RS12520	COG0351	phosphomethylpyrimidine kinase
L1B16_RS12520	COG0352	thiamine-phosphate diphosphorylase activity
L1B16_RS12545	COG0583	DNA-binding transcription factor activity
L1B16_RS12550	COG1741	Belongs to the pirin family
L1B16_RS12570	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L1B16_RS12575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L1B16_RS12580	COG2137	regulation of response to DNA damage stimulus
L1B16_RS12585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L1B16_RS12595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L1B16_RS12600	COG4771	TonB-dependent receptor
L1B16_RS12605	COG1546	Belongs to the CinA family
L1B16_RS12610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L1B16_RS12625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L1B16_RS12635	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L1B16_RS12640	COG1534	Rna-binding protein
L1B16_RS12655	COG1238	metal cluster binding
L1B16_RS12660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L1B16_RS12665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L1B16_RS12670	COG2840	Smr protein MutS2
L1B16_RS12680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L1B16_RS12685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L1B16_RS12695	COG0148	phosphopyruvate hydratase activity
L1B16_RS12745	COG1253	flavin adenine dinucleotide binding
L1B16_RS12760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1B16_RS12765	COG0477	Major facilitator Superfamily
L1B16_RS12770	COG1132	(ABC) transporter
L1B16_RS12775	COG1136	(ABC) transporter
L1B16_RS12795	COG0438	transferase activity, transferring glycosyl groups
L1B16_RS12800	COG0438	transferase activity, transferring glycosyl groups
L1B16_RS12805	COG2264	protein methyltransferase activity
L1B16_RS12835	COG2244	polysaccharide biosynthetic process
L1B16_RS12885	COG1595	DNA-templated transcription, initiation
L1B16_RS12895	COG1404	Belongs to the peptidase S8 family
L1B16_RS12900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L1B16_RS12920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1B16_RS12935	COG4191	Histidine kinase
L1B16_RS12935	COG0784	Response regulator, receiver
L1B16_RS12940	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
L1B16_RS12945	COG4191	Histidine kinase
L1B16_RS12945	COG0784	Response regulator, receiver
L1B16_RS12965	COG0840	transmembrane signaling receptor activity
L1B16_RS12980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1B16_RS13000	COG0840	transmembrane signaling receptor activity
L1B16_RS13025	COG0583	DNA-binding transcription factor activity
L1B16_RS13030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L1B16_RS13045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L1B16_RS13050	COG1605	Chorismate mutase
L1B16_RS13050	COG0077	Prephenate dehydratase
L1B16_RS13055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L1B16_RS13060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L1B16_RS13065	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
L1B16_RS13100	COG1228	amidohydrolase
L1B16_RS13105	COG2986	histidine ammonia-lyase
L1B16_RS13115	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L1B16_RS13130	COG4993	Dehydrogenase
L1B16_RS13140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L1B16_RS13155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L1B16_RS13160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L1B16_RS13165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L1B16_RS13175	COG3115	cell septum assembly
L1B16_RS13200	COG0316	Belongs to the HesB IscA family
L1B16_RS13205	COG0017	Asparaginyl-tRNA synthetase
L1B16_RS13270	COG0288	reversible hydration of carbon dioxide
L1B16_RS13275	COG0662	Cupin 2, conserved barrel domain protein
L1B16_RS13285	COG3844	kynureninase activity
L1B16_RS13290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1B16_RS13295	COG2925	Exonuclease
L1B16_RS13310	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L1B16_RS13320	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L1B16_RS13335	COG0488	(ABC) transporter
L1B16_RS13340	COG2264	protein methyltransferase activity
L1B16_RS13375	COG0494	nUDIX hydrolase
L1B16_RS13385	COG1024	Enoyl-CoA hydratase
L1B16_RS13395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L1B16_RS13425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L1B16_RS13430	COG0573	inorganic phosphate transmembrane transporter activity
L1B16_RS13435	COG0581	inorganic phosphate transmembrane transporter activity
L1B16_RS13440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L1B16_RS13445	COG0704	Plays a role in the regulation of phosphate uptake
L1B16_RS13455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L1B16_RS13470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1B16_RS13480	COG0557	exoribonuclease II activity
L1B16_RS13495	COG1960	acyl-CoA dehydrogenase activity
L1B16_RS13500	COG2226	methyltransferase
L1B16_RS13505	COG1410	methionine synthase
L1B16_RS13505	COG0646	methionine synthase
L1B16_RS13510	COG1410	methionine synthase
L1B16_RS13510	COG0646	methionine synthase
L1B16_RS13520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1B16_RS13545	COG2900	Belongs to the SlyX family
L1B16_RS13560	COG0386	Belongs to the glutathione peroxidase family
L1B16_RS13570	COG1725	Transcriptional regulator
L1B16_RS13575	COG1131	(ABC) transporter
L1B16_RS13605	COG1253	flavin adenine dinucleotide binding
L1B16_RS13620	COG2850	peptidyl-arginine hydroxylation
L1B16_RS13660	COG1619	proteins homologs of microcin C7 resistance protein MccF
L1B16_RS13670	COG1132	(ABC) transporter
L1B16_RS13675	COG0583	DNA-binding transcription factor activity
L1B16_RS13680	COG2274	protein secretion by the type I secretion system
L1B16_RS13700	COG0287	Prephenate dehydrogenase
L1B16_RS13700	COG1605	Chorismate mutase
L1B16_RS13705	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
L1B16_RS13715	COG0443	Heat shock 70 kDa protein
L1B16_RS13720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L1B16_RS13725	COG1420	regulation of RNA biosynthetic process
L1B16_RS13730	COG0497	DNA recombination
L1B16_RS13740	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L1B16_RS13755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L1B16_RS13865	COG0717	Belongs to the dCTP deaminase family
L1B16_RS13870	COG0489	protein tyrosine kinase activity
L1B16_RS13890	COG3590	peptidase
L1B16_RS13895	COG3590	peptidase
L1B16_RS13920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L1B16_RS13925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1B16_RS13930	COG2311	Membrane
L1B16_RS13935	COG1047	Peptidyl-prolyl cis-trans
L1B16_RS13940	COG0791	NLP P60 protein
L1B16_RS13945	COG0791	NLP P60 protein
L1B16_RS13960	COG1301	dicarboxylic acid transport
L1B16_RS13965	COG1785	Belongs to the alkaline phosphatase family
L1B16_RS13970	COG0037	tRNA processing
L1B16_RS13975	COG1722	exodeoxyribonuclease VII activity
L1B16_RS13980	COG0142	geranyltranstransferase activity
L1B16_RS13995	COG0312	modulator of DNA gyrase
L1B16_RS14005	COG0312	modulator of DNA gyrase
L1B16_RS14015	COG3164	Protein of unknown function
L1B16_RS14025	COG0424	maF-like protein
L1B16_RS14030	COG2968	Membrane
L1B16_RS14045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L1B16_RS14065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L1B16_RS14080	COG0495	leucyl-tRNA aminoacylation
L1B16_RS14090	COG3118	belongs to the thioredoxin family
L1B16_RS14115	COG2155	Conserved Protein
L1B16_RS14165	COG0475	glutathione-regulated potassium exporter activity
L1B16_RS14175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L1B16_RS14195	COG1187	pseudouridine synthase activity
L1B16_RS14200	COG5002	protein histidine kinase activity
L1B16_RS14200	COG5001	Diguanylate cyclase
L1B16_RS14340	COG0667	Aldo Keto reductase
L1B16_RS14345	COG2814	Major facilitator Superfamily
L1B16_RS14350	COG0583	DNA-binding transcription factor activity
L1B16_RS14360	COG2207	Transcriptional regulator
L1B16_RS14410	COG0735	belongs to the Fur family
L1B16_RS14415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L1B16_RS14440	COG4452	Inner membrane protein CreD
L1B16_RS14455	COG2205	protein histidine kinase activity
L1B16_RS14460	COG0745	RESPONSE REGULATOR receiver
L1B16_RS14465	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L1B16_RS14475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L1B16_RS14485	COG0643	Histidine kinase
L1B16_RS14485	COG2198	Histidine kinase
L1B16_RS14490	COG0840	transmembrane signaling receptor activity
L1B16_RS14495	COG0835	chemotaxis
L1B16_RS14500	COG2202	Pas domain
L1B16_RS14500	COG2199	diguanylate cyclase activity
L1B16_RS14500	COG2200	EAL domain
L1B16_RS14505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L1B16_RS14515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1B16_RS14520	COG3590	peptidase
L1B16_RS14530	COG0588	phosphoglycerate mutase activity
L1B16_RS14535	COG1515	deoxyribonuclease V activity
L1B16_RS14550	COG1741	Belongs to the pirin family
L1B16_RS14565	COG1741	Belongs to the pirin family
L1B16_RS14570	COG1966	Carbon starvation protein
L1B16_RS14575	COG2879	small protein
L1B16_RS14580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L1B16_RS14620	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L1B16_RS14625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1B16_RS14630	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L1B16_RS14635	COG2080	2 iron, 2 sulfur cluster binding
L1B16_RS14640	COG0604	alcohol dehydrogenase
L1B16_RS14640	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS14640	COG3321	synthase
L1B16_RS14645	COG3706	GGDEF domain
L1B16_RS14645	COG5001	Diguanylate cyclase
L1B16_RS14645	COG4251	negative regulation of phosphorylation
L1B16_RS14645	COG2203	Gaf domain
L1B16_RS14650	COG0629	single-stranded DNA binding
L1B16_RS14655	COG0142	geranyltranstransferase activity
L1B16_RS14680	COG0527	aspartate kinase activity
L1B16_RS14685	COG0384	phenazine biosynthesis protein PhzF
L1B16_RS14690	COG0384	phenazine biosynthesis protein PhzF
L1B16_RS14700	COG1764	response to oxidative stress
L1B16_RS14705	COG0540	Belongs to the ATCase OTCase family
L1B16_RS14710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L1B16_RS14715	COG1678	Uncharacterized ACR, COG1678
L1B16_RS14720	COG0519	Catalyzes the synthesis of GMP from XMP
L1B16_RS14740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L1B16_RS14755	COG4942	peptidase
L1B16_RS14775	COG0693	protein deglycase activity
L1B16_RS14785	COG1959	2 iron, 2 sulfur cluster binding
L1B16_RS14790	COG0719	Fe-S assembly protein
L1B16_RS14795	COG0396	ATPase activity
L1B16_RS14800	COG0719	Fe-S assembly protein
L1B16_RS14805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L1B16_RS14815	COG2146	nitrite reductase [NAD(P)H] activity
L1B16_RS14820	COG4774	siderophore transport
L1B16_RS14825	COG3128	pkhd-type hydroxylase
L1B16_RS14850	COG1477	protein flavinylation
L1B16_RS14855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L1B16_RS14870	COG1555	photosystem II stabilization
L1B16_RS14875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1B16_RS14885	COG3178	'Phosphotransferase
L1B16_RS14890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L1B16_RS14900	COG0628	permease
L1B16_RS14920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L1B16_RS14945	COG0271	Belongs to the BolA IbaG family
L1B16_RS14955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L1B16_RS14965	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L1B16_RS14970	COG1137	ATPase activity
L1B16_RS14985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1B16_RS15005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1B16_RS15010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L1B16_RS15015	COG2239	Acts as a magnesium transporter
L1B16_RS15025	COG1294	oxidase, subunit
L1B16_RS15030	COG1271	oxidase subunit
L1B16_RS15045	COG1113	amino acid transport
L1B16_RS15060	COG2197	response regulator
L1B16_RS15065	COG0531	amino acid
L1B16_RS15105	COG2814	Major facilitator Superfamily
L1B16_RS15110	COG0754	glutathionylspermidine amidase activity
L1B16_RS15135	COG1842	Phage shock protein A
L1B16_RS15155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L1B16_RS15160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L1B16_RS15170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L1B16_RS15175	COG0477	Major facilitator Superfamily
L1B16_RS15185	COG0784	Response regulator, receiver
L1B16_RS15185	COG2205	protein histidine kinase activity
L1B16_RS15185	COG2198	Histidine kinase
L1B16_RS15190	COG2353	YceI-like domain
L1B16_RS15195	COG3038	cytochrome b561
L1B16_RS15210	COG1760	l-serine dehydratase
L1B16_RS15220	COG0460	homoserine dehydrogenase
L1B16_RS15220	COG0527	aspartate kinase activity
L1B16_RS15225	COG0626	cystathionine gamma-synthase activity
L1B16_RS15230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1B16_RS15235	COG0739	heme binding
L1B16_RS15240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L1B16_RS15245	COG1272	protein, Hemolysin III
L1B16_RS15250	COG2982	Protein involved in outer membrane biogenesis
L1B16_RS15255	COG0517	IMP dehydrogenase activity
L1B16_RS15255	COG0516	GMP reductase activity
L1B16_RS15260	COG0463	Glycosyl transferase, family 2
L1B16_RS15265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1B16_RS15270	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L1B16_RS15280	COG4771	TonB-dependent receptor
L1B16_RS15285	COG1309	transcriptional regulator
L1B16_RS15295	COG1960	acyl-CoA dehydrogenase activity
L1B16_RS15325	COG0509	glycine decarboxylation via glycine cleavage system
L1B16_RS15330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L1B16_RS15340	COG0330	HflC and HflK could
L1B16_RS15345	COG1742	UPF0060 membrane protein
L1B16_RS15350	COG3956	TIGRFAM MazG family protein
L1B16_RS15360	COG0494	nUDIX hydrolase
L1B16_RS15370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L1B16_RS15375	COG0837	glucose binding
L1B16_RS15390	COG1388	LysM domain
L1B16_RS15390	COG3858	chitin binding
L1B16_RS15395	COG3525	Glycosyl hydrolase, family 20, catalytic domain
L1B16_RS15405	COG1472	Belongs to the glycosyl hydrolase 3 family
L1B16_RS15420	COG0531	amino acid
L1B16_RS15430	COG1486	melibiose metabolic process
L1B16_RS15440	COG3537	Alpha-1,2-mannosidase
L1B16_RS15480	COG3645	SOS response
L1B16_RS15500	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L1B16_RS15530	COG3142	Participates in the control of copper homeostasis
L1B16_RS15535	COG1446	asparaginase
L1B16_RS15540	COG2304	oxidoreductase activity
L1B16_RS15545	COG1595	DNA-templated transcription, initiation
L1B16_RS15570	COG0784	Response regulator, receiver
L1B16_RS15570	COG2198	Histidine kinase
L1B16_RS15570	COG0643	Histidine kinase
L1B16_RS15575	COG0840	transmembrane signaling receptor activity
L1B16_RS15580	COG0835	chemotaxis
L1B16_RS15595	COG0189	ligase activity
L1B16_RS15605	COG1397	ADP-ribosylglycohydrolase
L1B16_RS15615	COG1199	ATP-dependent helicase activity
L1B16_RS15625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1B16_RS15630	COG1215	transferase activity, transferring glycosyl groups
L1B16_RS15640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L1B16_RS15650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L1B16_RS15655	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
L1B16_RS15680	COG0837	glucose binding
L1B16_RS15695	COG1643	Atp-dependent helicase
L1B16_RS15700	COG0783	Belongs to the Dps family
L1B16_RS15705	COG0514	ATP-dependent DNA helicase (RecQ)
L1B16_RS15725	COG1187	pseudouridine synthase activity
L1B16_RS15735	COG0840	transmembrane signaling receptor activity
L1B16_RS15755	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L1B16_RS15775	COG0667	Aldo Keto reductase
L1B16_RS15780	COG0602	queuosine metabolic process
L1B16_RS15790	COG2885	chlorophyll binding
L1B16_RS15795	COG0823	Involved in the tonB-independent uptake of proteins
L1B16_RS15805	COG0848	biopolymer transport protein
L1B16_RS15815	COG0824	Thioesterase
L1B16_RS15820	COG2255	four-way junction helicase activity
L1B16_RS15875	COG0477	Major facilitator Superfamily
L1B16_RS15910	COG0488	(ABC) transporter
L1B16_RS15975	COG4772	TonB-dependent receptor
L1B16_RS15985	COG4264	IucA IucC family
L1B16_RS15990	COG2814	Major facilitator Superfamily
L1B16_RS15995	COG4264	IucA IucC family
L1B16_RS16000	COG0019	diaminopimelate decarboxylase activity
L1B16_RS16025	COG4206	TonB-dependent receptor
L1B16_RS16035	COG0542	response to heat
L1B16_RS16040	COG1116	anion transmembrane transporter activity
L1B16_RS16045	COG1116	anion transmembrane transporter activity
L1B16_RS16050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1B16_RS16055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L1B16_RS16060	COG0667	Aldo Keto reductase
L1B16_RS16065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1B16_RS16070	COG4771	TonB-dependent receptor
L1B16_RS16115	COG1877	trehalose-phosphatase activity
L1B16_RS16120	COG3387	PFAM Glycoside hydrolase 15-related
L1B16_RS16135	COG0840	transmembrane signaling receptor activity
L1B16_RS16145	COG1496	oxidoreductase activity
L1B16_RS16150	COG0564	pseudouridine synthase activity
L1B16_RS16155	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L1B16_RS16165	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L1B16_RS16165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1B16_RS16175	COG0045	succinate-CoA ligase (ADP-forming) activity
L1B16_RS16205	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L1B16_RS16225	COG0745	RESPONSE REGULATOR receiver
L1B16_RS16235	COG0189	ligase activity
L1B16_RS16310	COG0270	DNA (cytosine-5-)-methyltransferase activity
L1B16_RS16530	COG5001	Diguanylate cyclase
L1B16_RS16675	COG0583	DNA-binding transcription factor activity
L1B16_RS16680	COG1396	sequence-specific DNA binding
L1B16_RS16700	COG0582	viral genome integration into host DNA
L1B16_RS16730	COG0471	metal ion transport
L1B16_RS16730	COG3273	potassium ion transport
L1B16_RS16750	COG1970	mechanosensitive ion channel activity
L1B16_RS16760	COG1609	Transcriptional regulator
L1B16_RS16775	COG4948	Mandelate Racemase Muconate Lactonizing
L1B16_RS16785	COG2272	Belongs to the type-B carboxylesterase lipase family
L1B16_RS16790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1B16_RS16815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1B16_RS16820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_RS16825	COG2895	sulfate adenylyltransferase (ATP) activity
L1B16_RS16825	COG0529	Catalyzes the synthesis of activated sulfate
L1B16_RS16835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L1B16_RS16840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1B16_RS16845	COG0175	sulfate reduction
L1B16_RS16865	COG0784	Response regulator, receiver
L1B16_RS16865	COG2198	Histidine kinase
L1B16_RS16865	COG2205	protein histidine kinase activity
L1B16_RS16880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L1B16_RS16880	COG1648	precorrin-2 dehydrogenase activity
L1B16_RS16895	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
L1B16_RS16900	COG3588	fructose-bisphosphate aldolase
L1B16_RS16905	COG0469	pyruvate kinase activity
L1B16_RS16935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L1B16_RS16950	COG3047	cAMP biosynthetic process
L1B16_RS16960	COG3453	Protein conserved in bacteria
L1B16_RS16960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1B16_RS16965	COG0725	ABC transporter, periplasmic molybdate-binding protein
L1B16_RS16970	COG4149	molybdate abc transporter
L1B16_RS16975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L1B16_RS17020	COG1376	ErfK ybiS ycfS ynhG family protein
L1B16_RS17025	COG0739	heme binding
L1B16_RS17030	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS17035	COG0583	DNA-binding transcription factor activity
L1B16_RS17040	COG4773	Receptor
L1B16_RS17045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L1B16_RS17050	COG1301	dicarboxylic acid transport
L1B16_RS17080	COG0714	Associated with various cellular activities
L1B16_RS17110	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L1B16_RS17135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L1B16_RS17145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L1B16_RS17160	COG1561	YicC-like family, N-terminal region
L1B16_RS17165	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L1B16_RS17180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L1B16_RS17195	COG0006	proline dipeptidase activity
L1B16_RS17205	COG0006	proline dipeptidase activity
L1B16_RS17230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L1B16_RS17250	COG2912	Transglutaminase-like superfamily
L1B16_RS17260	COG1773	rubredoxin
L1B16_RS17265	COG0352	thiamine-phosphate diphosphorylase activity
L1B16_RS17275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L1B16_RS17290	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
L1B16_RS17295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L1B16_RS17325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L1B16_RS17345	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS17355	COG0671	phosphoesterase, PA-phosphatase related
L1B16_RS17360	COG3781	membrane
L1B16_RS17370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L1B16_RS17375	COG0563	adenylate kinase activity
L1B16_RS17390	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
L1B16_RS17400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L1B16_RS17420	COG3710	Transcriptional regulator
L1B16_RS17425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L1B16_RS17435	COG4946	Tricorn protease homolog
L1B16_RS17435	COG1506	peptidase
L1B16_RS17435	COG0823	Involved in the tonB-independent uptake of proteins
L1B16_RS17445	COG0405	Gamma-glutamyltransferase
L1B16_RS17450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L1B16_RS17470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1B16_RS17475	COG0473	3-isopropylmalate dehydrogenase activity
L1B16_RS17490	COG0066	3-isopropylmalate dehydratase activity
L1B16_RS17495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L1B16_RS17515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L1B16_RS17520	COG1538	Outer membrane efflux protein
L1B16_RS17525	COG1519	Transferase
L1B16_RS17530	COG1560	Kdo2-lipid A biosynthetic process
L1B16_RS17555	COG0280	phosphate acetyltransferase
L1B16_RS17555	COG0281	malic enzyme
L1B16_RS17570	COG4191	Histidine kinase
L1B16_RS17585	COG0583	DNA-binding transcription factor activity
L1B16_RS17595	COG0667	Aldo Keto reductase
L1B16_RS17600	COG2197	response regulator
L1B16_RS17610	COG0642	Histidine kinase
L1B16_RS17625	COG2851	Citrate transporter
L1B16_RS17630	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS17635	COG1609	Transcriptional regulator
L1B16_RS17640	COG2211	Major facilitator Superfamily
L1B16_RS17720	COG4773	Receptor
L1B16_RS17725	COG0726	polysaccharide deacetylase
L1B16_RS17730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L1B16_RS17745	COG3964	amidohydrolase
L1B16_RS17750	COG1228	amidohydrolase
L1B16_RS17795	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L1B16_RS17800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L1B16_RS17825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1B16_RS17825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1B16_RS17840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L1B16_RS17850	COG0488	(ABC) transporter
L1B16_RS17855	COG0242	peptide deformylase activity
L1B16_RS17920	COG2188	Transcriptional regulator
L1B16_RS17930	COG1450	Type ii and iii secretion system protein
L1B16_RS17945	COG3166	PFAM Fimbrial assembly family protein
L1B16_RS17950	COG3156	type II secretion system protein K
L1B16_RS17955	COG4795	General secretion pathway protein
L1B16_RS17960	COG2165	general secretion pathway protein
L1B16_RS17965	COG4970	Tfp pilus assembly protein FimT
L1B16_RS17970	COG2165	general secretion pathway protein
L1B16_RS17975	COG1459	type II secretion system
L1B16_RS17980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L1B16_RS17985	COG1404	Belongs to the peptidase S8 family
L1B16_RS17995	COG1404	Belongs to the peptidase S8 family
L1B16_RS18000	COG5295	Hep Hag repeat protein
L1B16_RS18005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L1B16_RS18005	COG0047	phosphoribosylformylglycinamidine synthase activity
L1B16_RS18010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L1B16_RS18015	COG4974	Belongs to the 'phage' integrase family
L1B16_RS18025	COG0795	lipopolysaccharide-transporting ATPase activity
L1B16_RS18045	COG0525	valine-tRNA ligase activity
L1B16_RS18070	COG1183	phosphatidylcholine synthase activity
L1B16_RS18080	COG0442	prolyl-tRNA aminoacylation
L1B16_RS18095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1B16_RS18100	COG1127	ABC transporter
L1B16_RS18105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L1B16_RS18105	COG3218	ABC-type transport auxiliary lipoprotein component
L1B16_RS18135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L1B16_RS18140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1B16_RS18145	COG0662	Cupin 2, conserved barrel domain protein
L1B16_RS18145	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
L1B16_RS18170	COG2086	electron transfer activity
L1B16_RS18185	COG0546	phosphoglycolate phosphatase activity
L1B16_RS18185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L1B16_RS18190	COG0277	FAD linked oxidase domain protein
L1B16_RS18195	COG0300	oxidoreductase activity
L1B16_RS18200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1B16_RS18240	COG1216	Glycosyl transferase, family 2
L1B16_RS18240	COG0438	transferase activity, transferring glycosyl groups
L1B16_RS18260	COG0626	cystathionine gamma-synthase activity
L1B16_RS18290	COG0625	glutathione transferase activity
L1B16_RS18300	COG0513	Belongs to the DEAD box helicase family
L1B16_RS18315	COG4771	TonB-dependent receptor
L1B16_RS18320	COG0720	synthase
L1B16_RS18330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L1B16_RS18335	COG1956	GAF domain-containing protein
L1B16_RS18345	COG2819	hydrolase of the alpha beta superfamily
L1B16_RS18355	COG0546	phosphoglycolate phosphatase activity
L1B16_RS18360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L1B16_RS18375	COG0339	signal peptide processing
L1B16_RS18420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1B16_RS18425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_RS18430	COG1136	(ABC) transporter
L1B16_RS18455	COG4191	Histidine kinase
L1B16_RS18465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L1B16_RS18480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L1B16_RS18500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L1B16_RS18505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L1B16_RS18515	COG0356	it plays a direct role in the translocation of protons across the membrane
L1B16_RS18540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L1B16_RS18550	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1B16_RS18585	COG2011	ABC-type metal ion transport system permease component
L1B16_RS18590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L1B16_RS18595	COG0697	spore germination
L1B16_RS18600	COG1666	GTP binding
L1B16_RS18610	COG0784	Response regulator, receiver
L1B16_RS18610	COG2198	Histidine kinase
L1B16_RS18610	COG5002	protein histidine kinase activity
L1B16_RS18630	COG1187	pseudouridine synthase activity
L1B16_RS18655	COG2202	Pas domain
L1B16_RS18655	COG2205	protein histidine kinase activity
L1B16_RS18675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L1B16_RS18680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1B16_RS18730	COG0842	Transport permease protein
L1B16_RS18735	COG1131	(ABC) transporter
L1B16_RS18740	COG0025	NhaP-type Na H and K H
L1B16_RS18750	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
L1B16_RS18755	COG1573	uracil-dna glycosylase
L1B16_RS18765	COG3384	dioxygenase
L1B16_RS18775	COG0583	DNA-binding transcription factor activity
L1B16_RS18785	COG0667	Aldo Keto reductase
L1B16_RS18795	COG3590	peptidase
L1B16_RS18810	COG0531	amino acid
L1B16_RS18825	COG2972	Histidine kinase
L1B16_RS18845	COG3685	Protein conserved in bacteria
L1B16_RS18850	COG3546	catalase activity
L1B16_RS18875	COG2204	response regulator
L1B16_RS18885	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS18910	COG1063	alcohol dehydrogenase
L1B16_RS18935	COG0583	DNA-binding transcription factor activity
L1B16_RS18940	COG2814	Major facilitator Superfamily
L1B16_RS18980	COG1131	(ABC) transporter
L1B16_RS19000	COG0251	oxidation-reduction process
L1B16_RS19015	COG0840	transmembrane signaling receptor activity
L1B16_RS19050	COG0659	secondary active sulfate transmembrane transporter activity
L1B16_RS19055	COG0038	chloride channel
L1B16_RS19110	COG0642	Histidine kinase
L1B16_RS19120	COG4695	Portal protein
L1B16_RS19175	COG3179	chitinase
L1B16_RS19195	COG0784	Response regulator, receiver
L1B16_RS19195	COG4191	Histidine kinase
L1B16_RS19230	COG0456	acetyltransferase
L1B16_RS19285	COG3081	Nucleoid-associated protein
L1B16_RS19375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L1B16_RS19380	COG1490	D-aminoacyl-tRNA deacylase activity
L1B16_RS19385	COG1560	Kdo2-lipid A biosynthetic process
L1B16_RS19395	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1B16_RS19410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L1B16_RS19430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L1B16_RS19430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L1B16_RS19440	COG0242	peptide deformylase activity
L1B16_RS19445	COG1652	LysM domain
L1B16_RS19450	COG0758	DNA mediated transformation
L1B16_RS19470	COG1754	DNA topoisomerase type I activity
L1B16_RS19470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L1B16_RS19475	COG0009	L-threonylcarbamoyladenylate synthase
L1B16_RS19490	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS19500	COG0616	signal peptide processing
L1B16_RS19505	COG0534	Mate efflux family protein
L1B16_RS19520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L1B16_RS19525	COG0625	glutathione transferase activity
L1B16_RS19540	COG1252	NADH dehydrogenase
L1B16_RS19545	COG2860	membrane
L1B16_RS19550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L1B16_RS19555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L1B16_RS19560	COG2201	protein-glutamate methylesterase activity
L1B16_RS19565	COG2177	Part of the ABC transporter FtsEX involved in
L1B16_RS19570	COG2884	Cell division ATP-binding protein ftsE
L1B16_RS19580	COG3118	belongs to the thioredoxin family
L1B16_RS19585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L1B16_RS19595	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
L1B16_RS19615	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L1B16_RS19615	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L1B16_RS19620	COG1473	amidohydrolase
L1B16_RS19630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1B16_RS19640	COG5383	Protein conserved in bacteria
L1B16_RS19680	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
L1B16_RS19685	COG3023	N-Acetylmuramoyl-L-alanine amidase
L1B16_RS19695	COG4948	Mandelate Racemase Muconate Lactonizing
L1B16_RS19705	COG0531	amino acid
L1B16_RS19720	COG4682	membrane
L1B16_RS19725	COG2133	pyrroloquinoline quinone binding
L1B16_RS19735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L1B16_RS19750	COG1610	YqeY-like protein
L1B16_RS19755	COG1295	ribonuclease BN
L1B16_RS19760	COG0358	DNA primase activity
L1B16_RS19780	COG0109	protoheme IX farnesyltransferase activity
L1B16_RS19810	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
L1B16_RS19825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L1B16_RS19870	COG0739	heme binding
L1B16_RS19885	COG2211	Major facilitator Superfamily
L1B16_RS19890	COG0708	Exodeoxyribonuclease III
L1B16_RS19905	COG1192	Involved in chromosome partitioning
L1B16_RS19910	COG1475	DNA binding
L1B16_RS19930	COG0463	Glycosyl transferase, family 2
L1B16_RS19955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L1B16_RS19965	COG0018	arginyl-trna synthetase
L1B16_RS19980	COG4221	oxidoreductase activity
L1B16_RS19985	COG2755	lipolytic protein G-D-S-L family
L1B16_RS19985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L1B16_RS19995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L1B16_RS19995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L1B16_RS20000	COG1166	arginine decarboxylase activity
L1B16_RS20005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L1B16_RS20035	COG2960	long-chain fatty acid transporting porin activity
L1B16_RS20070	COG0210	DNA helicase
L1B16_RS20125	COG4943	cyclic-guanylate-specific phosphodiesterase activity
L1B16_RS20175	COG1090	epimerase
L1B16_RS20185	COG0642	Histidine kinase
L1B16_RS20225	COG0628	permease
L1B16_RS20230	COG1011	Hydrolase
L1B16_RS20235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L1B16_RS20265	COG2197	response regulator
L1B16_RS20270	COG4585	Histidine kinase
L1B16_RS20275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_RS20280	COG1136	(ABC) transporter
L1B16_RS20305	COG0697	spore germination
L1B16_RS20320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1B16_RS20325	COG0180	Tryptophanyl-tRNA synthetase
L1B16_RS20330	COG3237	CsbD-like
L1B16_RS20370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L1B16_RS20385	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L1B16_RS20390	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L1B16_RS20390	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L1B16_RS20430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L1B16_RS20455	COG1199	ATP-dependent helicase activity
L1B16_RS20550	COG4555	ABC transporter
L1B16_RS20560	COG1476	TRANSCRIPTIONal
L1B16_RS20595	COG1131	(ABC) transporter
L1B16_RS20600	COG0842	Transport permease protein
L1B16_RS20605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L1B16_RS20615	COG1607	acyl-coa hydrolase
L1B16_RS20630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1B16_RS20635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1B16_RS20645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L1B16_RS20645	COG1042	CoA-binding domain protein
L1B16_RS20645	COG0045	succinate-CoA ligase (ADP-forming) activity
L1B16_RS20650	COG2239	Acts as a magnesium transporter
L1B16_RS20660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L1B16_RS20665	COG3387	PFAM Glycoside hydrolase 15-related
L1B16_RS20680	COG3100	YcgL domain-containing protein
L1B16_RS20685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L1B16_RS20710	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS20740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L1B16_RS20755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1B16_RS20840	COG0210	DNA helicase
L1B16_RS20850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1B16_RS20855	COG0583	DNA-binding transcription factor activity
L1B16_RS20860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L1B16_RS20870	COG2159	amidohydrolase
L1B16_RS20890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_RS20910	COG0357	Ribosomal RNA small subunit methyltransferase G
L1B16_RS20915	COG3540	Alkaline phosphatase
L1B16_RS20925	COG2091	lysine biosynthetic process via aminoadipic acid
L1B16_RS20945	COG1940	carbohydrate kinase activity
L1B16_RS20955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L1B16_RS20965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1B16_RS21010	COG3507	Belongs to the glycosyl hydrolase 43 family
L1B16_RS21025	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS21030	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1B16_RS21035	COG4948	Mandelate Racemase Muconate Lactonizing
L1B16_RS21040	COG3254	rhamnose metabolic process
L1B16_RS21045	COG0738	Major facilitator superfamily
L1B16_RS21050	COG1414	Transcriptional regulator
L1B16_RS21055	COG1971	Probably functions as a manganese efflux pump
L1B16_RS21060	COG2205	protein histidine kinase activity
L1B16_RS21060	COG0784	Response regulator, receiver
L1B16_RS21065	COG3459	Glycosyltransferase 36 associated
L1B16_RS21070	COG2211	Major facilitator Superfamily
L1B16_RS21075	COG3265	gluconokinase activity
L1B16_RS21080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L1B16_RS21100	COG2911	Protein conserved in bacteria
L1B16_RS21105	COG0729	surface antigen
L1B16_RS21110	COG4771	TonB-dependent receptor
L1B16_RS21115	COG0457	Tetratricopeptide repeat
L1B16_RS21130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L1B16_RS21135	COG0519	Catalyzes the synthesis of GMP from XMP
L1B16_RS21135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L1B16_RS21145	COG0805	protein transport
L1B16_RS21150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L1B16_RS21155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L1B16_RS21165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L1B16_RS21180	COG2974	May be involved in recombination
L1B16_RS21185	COG0037	tRNA processing
L1B16_RS21205	COG3661	Belongs to the glycosyl hydrolase 67 family
L1B16_RS21215	COG4948	Mandelate Racemase Muconate Lactonizing
L1B16_RS21225	COG1472	Belongs to the glycosyl hydrolase 3 family
L1B16_RS21230	COG0246	Mannitol dehydrogenase
L1B16_RS21255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L1B16_RS21285	COG3250	beta-galactosidase activity
L1B16_RS21290	COG1904	glucuronate isomerase
L1B16_RS21310	COG2211	Major facilitator Superfamily
L1B16_RS21360	COG0604	alcohol dehydrogenase
L1B16_RS21360	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_RS21360	COG3321	synthase
L1B16_RS21365	COG2937	Belongs to the GPAT DAPAT family
L1B16_RS21395	COG0284	orotidine-5'-phosphate decarboxylase activity
L1B16_RS21400	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
L1B16_RS21405	COG3132	Protein of unknown function, DUF480
L1B16_RS21420	COG0210	DNA helicase
L1B16_RS21425	COG1435	thymidine kinase activity
L1B16_RS21435	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
L1B16_RS21445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1B16_RS21475	COG3135	benzoate transporter
L1B16_RS21500	COG0676	glucose-6-phosphate 1-epimerase activity
L1B16_RS21525	COG0730	response to heat
L1B16_RS21550	COG0302	gtp cyclohydrolase
L1B16_RS21565	COG1566	PFAM secretion protein HlyD family protein
L1B16_RS21575	COG1289	transmembrane transporter activity
L1B16_RS21580	COG0477	Major facilitator Superfamily
L1B16_RS21590	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
L1B16_RS21595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1B16_RS21660	COG0564	pseudouridine synthase activity
L1B16_RS21690	COG3549	Plasmid maintenance system killer
L1B16_RS21695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L1B16_RS21700	COG1074	ATP-dependent DNA helicase activity
L1B16_RS21705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L1B16_RS21740	COG1127	ABC transporter
L1B16_RS21745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1B16_RS21750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L1B16_RS21765	COG2853	Lipoprotein
L1B16_RS21775	COG0386	Belongs to the glutathione peroxidase family
L1B16_RS21785	COG1322	Protein conserved in bacteria
L1B16_RS21795	COG0531	amino acid
L1B16_RS21800	COG3537	Alpha-1,2-mannosidase
L1B16_RS21815	COG3706	GGDEF domain
L1B16_RS21820	COG3835	regulator
L1B16_RS21825	COG1929	Belongs to the glycerate kinase type-1 family
L1B16_RS21830	COG2271	Major facilitator Superfamily
L1B16_RS21880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L1B16_RS21885	COG0861	Integral membrane protein TerC family
L1B16_RS21895	COG0584	glycerophosphoryl diester phosphodiesterase
L1B16_RS21905	COG0671	phosphoesterase, PA-phosphatase related
L1B16_RS21910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L1B16_RS21915	COG0726	polysaccharide deacetylase
L1B16_RS21920	COG0706	membrane insertase activity
L1B16_RS21980	COG1674	ftsk spoiiie
L1B16_RS22010	COG1192	Involved in chromosome partitioning
L1B16_RS22065	COG2951	lytic endotransglycosylase activity
L1B16_RS22070	COG4644	lycopene metabolic process
L1B16_RS22150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs