locus-tag	class	description
XAC29_RS22770	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XAC29_RS22780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XAC29_RS22785	COG0187	DNA topoisomerase II activity
XAC29_RS22795	COG0501	Belongs to the peptidase M48B family
XAC29_RS22825	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XAC29_RS22835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC29_RS22880	COG0793	Belongs to the peptidase S41A family
XAC29_RS22885	COG4942	peptidase
XAC29_RS22895	COG2234	aminopeptidase activity
XAC29_RS22905	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC29_RS22910	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC29_RS22920	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC29_RS22925	COG1064	alcohol dehydrogenase
XAC29_RS22930	COG0493	'glutamate synthase
XAC29_RS22935	COG0069	glutamate synthase activity
XAC29_RS22935	COG0067	glutamate synthase
XAC29_RS22935	COG0070	glutamate synthase
XAC29_RS22980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
XAC29_RS22995	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XAC29_RS23000	COG0297	glycogen (starch) synthase activity
XAC29_RS23000	COG0438	transferase activity, transferring glycosyl groups
XAC29_RS23020	COG0367	asparagine synthase
XAC29_RS23050	COG1132	(ABC) transporter
XAC29_RS23080	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XAC29_RS23170	COG1205	dead DEAH box helicase
XAC29_RS23170	COG1111	helicase
XAC29_RS23175	COG1272	protein, Hemolysin III
XAC29_RS23190	COG0300	oxidoreductase activity
XAC29_RS23195	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS23215	COG2249	NAD(P)H dehydrogenase (quinone) activity
XAC29_RS23225	COG2801	Transposase and inactivated derivatives
XAC29_RS23270	COG3237	CsbD-like
XAC29_RS23320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAC29_RS23330	COG0477	Major facilitator Superfamily
XAC29_RS23370	COG0714	Associated with various cellular activities
XAC29_RS23400	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XAC29_RS23410	COG4772	TonB-dependent receptor
XAC29_RS23420	COG0662	Cupin 2, conserved barrel domain protein
XAC29_RS23425	COG1012	belongs to the aldehyde dehydrogenase family
XAC29_RS23450	COG1304	FMN binding
XAC29_RS23465	COG4585	Histidine kinase
XAC29_RS23470	COG2197	response regulator
XAC29_RS23490	COG3710	Transcriptional regulator
XAC29_RS23495	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XAC29_RS23565	COG2801	Transposase and inactivated derivatives
XAC29_RS23570	COG0366	Alpha amylase catalytic
XAC29_RS23575	COG0366	Alpha amylase catalytic
XAC29_RS23580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAC29_RS23600	COG0657	acetylesterase activity
XAC29_RS23600	COG2755	lipolytic protein G-D-S-L family
XAC29_RS23610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XAC29_RS23625	COG3507	Belongs to the glycosyl hydrolase 43 family
XAC29_RS23630	COG1609	Transcriptional regulator
XAC29_RS23635	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XAC29_RS23640	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS23650	COG2755	lipolytic protein G-D-S-L family
XAC29_RS23665	COG3186	Phenylalanine-4-hydroxylase
XAC29_RS23670	COG1522	sequence-specific DNA binding
XAC29_RS23680	COG1752	Esterase of the alpha-beta hydrolase superfamily
XAC29_RS23690	COG1119	ATPase activity
XAC29_RS23705	COG1125	glycine betaine transport
XAC29_RS23720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XAC29_RS23725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XAC29_RS23745	COG1396	sequence-specific DNA binding
XAC29_RS23770	COG0489	protein tyrosine kinase activity
XAC29_RS23775	COG2062	phosphohistidine phosphatase, SixA
XAC29_RS23785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC29_RS23830	COG1968	undecaprenyl-diphosphatase activity
XAC29_RS23835	COG0174	glutamine synthetase
XAC29_RS23840	COG0347	Belongs to the P(II) protein family
XAC29_RS23845	COG0004	ammonium transporteR
XAC29_RS23850	COG3852	Histidine kinase
XAC29_RS23855	COG2204	response regulator
XAC29_RS23860	COG2032	superoxide dismutase activity
XAC29_RS23865	COG2032	superoxide dismutase activity
XAC29_RS23870	COG0346	lactoylglutathione lyase activity
XAC29_RS23880	COG0183	Belongs to the thiolase family
XAC29_RS23915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XAC29_RS23920	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XAC29_RS23925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XAC29_RS23935	COG0028	Belongs to the TPP enzyme family
XAC29_RS23940	COG2205	protein histidine kinase activity
XAC29_RS23965	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XAC29_RS23980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAC29_RS23990	COG0596	Alpha beta hydrolase
XAC29_RS23995	COG0727	PFAM Uncharacterised protein family (UPF0153)
XAC29_RS24000	COG0318	PFAM AMP-dependent synthetase and ligase
XAC29_RS24005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAC29_RS24020	COG1181	Belongs to the D-alanine--D-alanine ligase family
XAC29_RS24030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XAC29_RS24040	COG0564	pseudouridine synthase activity
XAC29_RS24065	COG0339	signal peptide processing
XAC29_RS24095	COG0475	glutathione-regulated potassium exporter activity
XAC29_RS24100	COG0583	DNA-binding transcription factor activity
XAC29_RS24105	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XAC29_RS24110	COG2224	Isocitrate lyase
XAC29_RS24140	COG4770	biotin carboxylase activity
XAC29_RS24145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XAC29_RS24150	COG1960	acyl-CoA dehydrogenase activity
XAC29_RS24205	COG0523	cobalamin synthesis protein
XAC29_RS24220	COG0697	spore germination
XAC29_RS24230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XAC29_RS24235	COG1846	Transcriptional regulator
XAC29_RS24240	COG1764	response to oxidative stress
XAC29_RS24270	COG2130	NADP-dependent
XAC29_RS24285	COG1187	pseudouridine synthase activity
XAC29_RS24300	COG1643	Atp-dependent helicase
XAC29_RS24310	COG4807	Protein conserved in bacteria
XAC29_RS24315	COG2351	hydroxyisourate hydrolase activity
XAC29_RS24320	COG2072	flavoprotein involved in K transport
XAC29_RS24340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XAC29_RS24375	COG1957	nucleoside hydrolase
XAC29_RS24385	COG2252	PERMEase
XAC29_RS24410	COG0084	hydrolase, TatD family'
XAC29_RS24425	COG0583	DNA-binding transcription factor activity
XAC29_RS24430	COG2814	Major facilitator Superfamily
XAC29_RS24445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XAC29_RS24450	COG1902	pentaerythritol trinitrate reductase activity
XAC29_RS24470	COG0745	RESPONSE REGULATOR receiver
XAC29_RS24475	COG2205	protein histidine kinase activity
XAC29_RS24480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC29_RS24500	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XAC29_RS24505	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XAC29_RS24510	COG0583	DNA-binding transcription factor activity
XAC29_RS24545	COG0702	epimerase
XAC29_RS24550	COG1733	regulation of RNA biosynthetic process
XAC29_RS24595	COG0129	dihydroxy-acid dehydratase activity
XAC29_RS24615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XAC29_RS24670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XAC29_RS24675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XAC29_RS24700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XAC29_RS24705	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XAC29_RS24715	COG3485	protocatechuate 3,4-dioxygenase
XAC29_RS24720	COG3485	protocatechuate 3,4-dioxygenase
XAC29_RS24730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAC29_RS24735	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XAC29_RS24745	COG1414	Transcriptional regulator
XAC29_RS24755	COG0657	acetylesterase activity
XAC29_RS24765	COG0445	tRNA wobble uridine modification
XAC29_RS24775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XAC29_RS24805	COG2267	carboxylic ester hydrolase activity
XAC29_RS24815	COG0156	8-amino-7-oxononanoate synthase activity
XAC29_RS24820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XAC29_RS24825	COG1040	competence protein
XAC29_RS24830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XAC29_RS24905	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XAC29_RS24975	COG3264	Mechanosensitive ion channel
XAC29_RS24975	COG1511	domain protein
XAC29_RS24980	COG1368	sulfuric ester hydrolase activity
XAC29_RS24985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XAC29_RS24990	COG2354	Protein conserved in bacteria
XAC29_RS25000	COG0297	glycogen (starch) synthase activity
XAC29_RS25005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAC29_RS25010	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAC29_RS25035	COG0702	epimerase
XAC29_RS25040	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS25075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAC29_RS25080	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS25090	COG0513	Belongs to the DEAD box helicase family
XAC29_RS25110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XAC29_RS25120	COG3483	tryptophan 2,3-dioxygenase activity
XAC29_RS25125	COG3104	oligopeptide transport
XAC29_RS25145	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XAC29_RS25160	COG1320	monovalent cation:proton antiporter activity
XAC29_RS25165	COG2212	antiporter activity
XAC29_RS25175	COG0651	ATP synthesis coupled electron transport
XAC29_RS25180	COG1006	Multisubunit Na H antiporter MnhC subunit
XAC29_RS25185	COG2111	Na H antiporter
XAC29_RS25185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XAC29_RS25205	COG3179	chitinase
XAC29_RS25225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XAC29_RS25230	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XAC29_RS25245	COG0456	acetyltransferase
XAC29_RS25250	COG1597	lipid kinase activity
XAC29_RS25275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XAC29_RS25280	COG0134	indole-3-glycerol-phosphate synthase activity
XAC29_RS25290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAC29_RS25295	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XAC29_RS25305	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XAC29_RS25315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XAC29_RS25330	COG1051	belongs to the nudix hydrolase family
XAC29_RS25370	COG0316	Belongs to the HesB IscA family
XAC29_RS25395	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XAC29_RS25415	COG2814	Major facilitator Superfamily
XAC29_RS25420	COG0583	DNA-binding transcription factor activity
XAC29_RS25425	COG2814	Major facilitator Superfamily
XAC29_RS25430	COG1289	transmembrane transporter activity
XAC29_RS25440	COG0151	Belongs to the GarS family
XAC29_RS25450	COG0138	bifunctional purine biosynthesis protein purh
XAC29_RS25455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XAC29_RS25460	COG2267	carboxylic ester hydrolase activity
XAC29_RS25465	COG2453	phosphatase
XAC29_RS25465	COG0671	phosphoesterase, PA-phosphatase related
XAC29_RS25490	COG4589	Belongs to the CDS family
XAC29_RS25495	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XAC29_RS25520	COG2264	protein methyltransferase activity
XAC29_RS25535	COG0439	Biotin carboxylase
XAC29_RS25545	COG0511	ligase activity, forming carbon-carbon bonds
XAC29_RS25550	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XAC29_RS25560	COG1324	tolerance protein
XAC29_RS25585	COG0300	oxidoreductase activity
XAC29_RS25590	COG2356	endonuclease I
XAC29_RS25600	COG0459	protein refolding
XAC29_RS25615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XAC29_RS25630	COG3386	PFAM SMP-30 Gluconolaconase
XAC29_RS25640	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XAC29_RS25645	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XAC29_RS25665	COG0778	Nitroreductase
XAC29_RS25675	COG2353	YceI-like domain
XAC29_RS25705	COG3052	prosthetic group binding
XAC29_RS25730	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XAC29_RS25740	COG1802	Transcriptional regulator
XAC29_RS25795	COG4221	oxidoreductase activity
XAC29_RS25810	COG4221	oxidoreductase activity
XAC29_RS25820	COG0435	Glutathione S-transferase
XAC29_RS25845	COG2409	Drug exporters of the RND superfamily
XAC29_RS25850	COG0823	Involved in the tonB-independent uptake of proteins
XAC29_RS25850	COG1506	peptidase
XAC29_RS25890	COG0697	spore germination
XAC29_RS25905	COG1113	amino acid transport
XAC29_RS25925	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XAC29_RS25960	COG5001	Diguanylate cyclase
XAC29_RS25965	COG0840	transmembrane signaling receptor activity
XAC29_RS25970	COG5297	Belongs to the glycosyl hydrolase family 6
XAC29_RS25970	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC29_RS25975	COG0659	secondary active sulfate transmembrane transporter activity
XAC29_RS26000	COG2943	transferase activity, transferring hexosyl groups
XAC29_RS26010	COG3275	phosphorelay sensor kinase activity
XAC29_RS26020	COG0181	hydroxymethylbilane synthase activity
XAC29_RS26045	COG1505	serine-type exopeptidase activity
XAC29_RS26050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XAC29_RS26055	COG0436	Aminotransferase
XAC29_RS26065	COG2832	Protein of unknown function (DUF454)
XAC29_RS26075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XAC29_RS26085	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XAC29_RS26090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XAC29_RS26095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XAC29_RS26120	COG2226	methyltransferase
XAC29_RS26125	COG3300	MHYT domain
XAC29_RS26125	COG5001	Diguanylate cyclase
XAC29_RS26130	COG0308	aminopeptidase N
XAC29_RS26180	COG3284	Transcriptional regulator
XAC29_RS26185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAC29_RS26190	COG1077	Cell shape determining protein MreB Mrl
XAC29_RS26195	COG1792	Involved in formation and maintenance of cell shape
XAC29_RS26210	COG0772	Belongs to the SEDS family
XAC29_RS26220	COG2951	lytic endotransglycosylase activity
XAC29_RS26225	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XAC29_RS26235	COG1686	Belongs to the peptidase S11 family
XAC29_RS26245	COG2921	Belongs to the UPF0250 family
XAC29_RS26250	COG0321	lipoyl(octanoyl) transferase activity
XAC29_RS26255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XAC29_RS26270	COG0583	DNA-binding transcription factor activity
XAC29_RS26280	COG1056	cytidyltransferase-related domain
XAC29_RS26280	COG1051	belongs to the nudix hydrolase family
XAC29_RS26320	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XAC29_RS26325	COG0673	inositol 2-dehydrogenase activity
XAC29_RS26330	COG2823	Periplasmic or secreted lipoprotein
XAC29_RS26335	COG4251	negative regulation of phosphorylation
XAC29_RS26340	COG0784	Response regulator, receiver
XAC29_RS26345	COG4191	Histidine kinase
XAC29_RS26350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XAC29_RS26405	COG1459	type II secretion system
XAC29_RS26470	COG2188	Transcriptional regulator
XAC29_RS26480	COG1609	Transcriptional regulator
XAC29_RS26485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XAC29_RS26490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XAC29_RS26500	COG0617	tRNA 3'-terminal CCA addition
XAC29_RS26505	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XAC29_RS26510	COG1012	belongs to the aldehyde dehydrogenase family
XAC29_RS26515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XAC29_RS26525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XAC29_RS26540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XAC29_RS26545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XAC29_RS26560	COG2205	protein histidine kinase activity
XAC29_RS26565	COG2205	protein histidine kinase activity
XAC29_RS26595	COG3791	Glutathione-dependent formaldehyde-activating
XAC29_RS26610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XAC29_RS26620	COG0697	spore germination
XAC29_RS26630	COG0488	(ABC) transporter
XAC29_RS26640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XAC29_RS26645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XAC29_RS26655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XAC29_RS26655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XAC29_RS26675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XAC29_RS26680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XAC29_RS26685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XAC29_RS26705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XAC29_RS26710	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XAC29_RS26715	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XAC29_RS26720	COG2205	protein histidine kinase activity
XAC29_RS26725	COG0745	RESPONSE REGULATOR receiver
XAC29_RS26740	COG0277	FAD linked oxidase domain protein
XAC29_RS26745	COG1988	membrane-bound metal-dependent
XAC29_RS26750	COG0792	nuclease activity
XAC29_RS26780	COG0275	rRNA processing
XAC29_RS26785	COG3116	cell division
XAC29_RS26795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XAC29_RS26800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XAC29_RS26805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XAC29_RS26815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XAC29_RS26820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XAC29_RS26825	COG1181	Belongs to the D-alanine--D-alanine ligase family
XAC29_RS26830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XAC29_RS26845	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XAC29_RS26855	COG0739	heme binding
XAC29_RS26860	COG0653	protein targeting
XAC29_RS26865	COG0494	nUDIX hydrolase
XAC29_RS26875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XAC29_RS26885	COG0604	alcohol dehydrogenase
XAC29_RS26885	COG3321	synthase
XAC29_RS26885	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS26905	COG0366	Alpha amylase catalytic
XAC29_RS26935	COG2226	methyltransferase
XAC29_RS26940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XAC29_RS26950	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XAC29_RS26985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XAC29_RS26995	COG4106	trans-aconitate 2-methyltransferase activity
XAC29_RS27000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XAC29_RS27010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAC29_RS27015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XAC29_RS27020	COG0667	Aldo Keto reductase
XAC29_RS27030	COG4771	TonB-dependent receptor
XAC29_RS27050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XAC29_RS27055	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XAC29_RS27065	COG2175	clavaminate synthase activity
XAC29_RS27075	COG4181	ATPase activity
XAC29_RS27090	COG0642	Histidine kinase
XAC29_RS27105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XAC29_RS27125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XAC29_RS27130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XAC29_RS27145	COG3829	transcription factor binding
XAC29_RS27155	COG1116	anion transmembrane transporter activity
XAC29_RS27160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XAC29_RS27170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XAC29_RS27175	COG0431	NADPH-dependent FMN reductase
XAC29_RS27200	COG0747	negative chemotaxis
XAC29_RS27210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XAC29_RS27220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XAC29_RS27225	COG2967	ApaG domain
XAC29_RS27230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XAC29_RS27235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XAC29_RS27240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAC29_RS27245	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XAC29_RS27255	COG0123	including yeast histone deacetylase and acetoin utilization protein
XAC29_RS27260	COG2096	Adenosyltransferase
XAC29_RS27270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAC29_RS27275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAC29_RS27305	COG3384	dioxygenase
XAC29_RS27310	COG0583	DNA-binding transcription factor activity
XAC29_RS27325	COG1024	Enoyl-CoA hydratase
XAC29_RS27345	COG3386	PFAM SMP-30 Gluconolaconase
XAC29_RS27355	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XAC29_RS27380	COG0697	spore germination
XAC29_RS27390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAC29_RS27415	COG5002	protein histidine kinase activity
XAC29_RS27415	COG0784	Response regulator, receiver
XAC29_RS27415	COG2205	protein histidine kinase activity
XAC29_RS27420	COG2197	response regulator
XAC29_RS27430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XAC29_RS27440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XAC29_RS27445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAC29_RS27450	COG0583	DNA-binding transcription factor activity
XAC29_RS27455	COG3634	alkyl hydroperoxide reductase activity
XAC29_RS27465	COG2890	protein-(glutamine-N5) methyltransferase activity
XAC29_RS27485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAC29_RS27485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAC29_RS27515	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XAC29_RS27545	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XAC29_RS27560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XAC29_RS27565	COG1404	Belongs to the peptidase S8 family
XAC29_RS27570	COG1404	Belongs to the peptidase S8 family
XAC29_RS27575	COG1404	Belongs to the peptidase S8 family
XAC29_RS27580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XAC29_RS27605	COG1295	ribonuclease BN
XAC29_RS27610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAC29_RS27615	COG1254	Belongs to the acylphosphatase family
XAC29_RS27630	COG0521	Mo-molybdopterin cofactor biosynthetic process
XAC29_RS27640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XAC29_RS27645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XAC29_RS27655	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XAC29_RS27660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XAC29_RS27670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XAC29_RS27675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XAC29_RS27680	COG0193	aminoacyl-tRNA hydrolase activity
XAC29_RS27685	COG0012	GTP binding
XAC29_RS27705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XAC29_RS27720	COG0250	Participates in transcription elongation, termination and antitermination
XAC29_RS27725	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XAC29_RS27730	COG0081	regulation of translation
XAC29_RS27735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XAC29_RS27740	COG0222	ribosome binding
XAC29_RS27745	COG0085	RNA polymerase activity
XAC29_RS27750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XAC29_RS27755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XAC29_RS27760	COG0049	tRNA binding
XAC29_RS27765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XAC29_RS27770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XAC29_RS27775	COG0051	transcription antitermination factor activity, RNA binding
XAC29_RS27780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XAC29_RS27785	COG0088	Forms part of the polypeptide exit tunnel
XAC29_RS27790	COG0089	rRNA binding
XAC29_RS27795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XAC29_RS27800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XAC29_RS27810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XAC29_RS27815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XAC29_RS27820	COG0255	Belongs to the universal ribosomal protein uL29 family
XAC29_RS27825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XAC29_RS27835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XAC29_RS27840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XAC29_RS27850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XAC29_RS27855	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XAC29_RS27860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XAC29_RS27870	COG1841	ribosomal large subunit assembly
XAC29_RS27875	COG0200	Binds to the 23S rRNA
XAC29_RS27880	COG0201	protein transport
XAC29_RS27905	COG0203	ribosomal protein L17
XAC29_RS27910	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XAC29_RS27925	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XAC29_RS27935	COG0154	amidase activity
XAC29_RS27945	COG1217	gtp-binding protein TYPA
XAC29_RS27950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XAC29_RS27960	COG0039	L-malate dehydrogenase activity
XAC29_RS27965	COG0625	glutathione transferase activity
XAC29_RS27975	COG0446	pyridine nucleotide-disulphide oxidoreductase
XAC29_RS27975	COG1902	pentaerythritol trinitrate reductase activity
XAC29_RS27980	COG0604	alcohol dehydrogenase
XAC29_RS28005	COG0156	8-amino-7-oxononanoate synthase activity
XAC29_RS28010	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XAC29_RS28015	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XAC29_RS28020	COG4208	sulfate ABC transporter
XAC29_RS28025	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XAC29_RS28035	COG1063	alcohol dehydrogenase
XAC29_RS28065	COG0406	alpha-ribazole phosphatase activity
XAC29_RS28070	COG0285	dihydrofolate synthase activity
XAC29_RS28090	COG2833	Protein of unknown function (DUF455)
XAC29_RS28100	COG3291	Pkd domain containing protein
XAC29_RS28110	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAC29_RS28115	COG0671	phosphoesterase, PA-phosphatase related
XAC29_RS28120	COG0438	transferase activity, transferring glycosyl groups
XAC29_RS28130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XAC29_RS28145	COG4783	chaperone-mediated protein folding
XAC29_RS28160	COG0473	3-isopropylmalate dehydrogenase activity
XAC29_RS28285	COG2801	Transposase and inactivated derivatives
XAC29_RS28300	COG3852	Histidine kinase
XAC29_RS28310	COG0544	peptidyl-prolyl cis-trans isomerase activity
XAC29_RS28320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XAC29_RS28350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAC29_RS28360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAC29_RS28370	COG0328	RNA-DNA hybrid ribonuclease activity
XAC29_RS28375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XAC29_RS28380	COG0631	protein serine/threonine phosphatase activity
XAC29_RS28400	COG3642	lipopolysaccharide core region biosynthetic process
XAC29_RS28405	COG1234	tRNA 3'-trailer cleavage
XAC29_RS28410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XAC29_RS28420	COG0315	cyclic pyranopterin monophosphate synthase activity
XAC29_RS28425	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XAC29_RS28430	COG0314	molybdopterin synthase activity
XAC29_RS28440	COG0339	signal peptide processing
XAC29_RS28475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XAC29_RS28480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XAC29_RS28485	COG0537	adenosine 5'-monophosphoramidase activity
XAC29_RS28505	COG0714	Associated with various cellular activities
XAC29_RS28525	COG0424	maF-like protein
XAC29_RS28530	COG1399	metal-binding, possibly nucleic acid-binding protein
XAC29_RS28535	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XAC29_RS28540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAC29_RS28555	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS28570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XAC29_RS28575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XAC29_RS28600	COG3829	transcription factor binding
XAC29_RS28620	COG3609	addiction module antidote protein, CC2985 family
XAC29_RS28645	COG2373	Large extracellular alpha-helical protein
XAC29_RS28670	COG0678	peroxiredoxin activity
XAC29_RS28690	COG0330	HflC and HflK could
XAC29_RS28695	COG0330	HflC and HflK could
XAC29_RS28705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XAC29_RS28710	COG0308	aminopeptidase N
XAC29_RS28720	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS28725	COG1309	transcriptional regulator
XAC29_RS28800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XAC29_RS28810	COG3387	PFAM Glycoside hydrolase 15-related
XAC29_RS28815	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS28820	COG3537	Alpha-1,2-mannosidase
XAC29_RS28840	COG0492	ferredoxin-NADP+ reductase activity
XAC29_RS28865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XAC29_RS28870	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XAC29_RS28875	COG2080	2 iron, 2 sulfur cluster binding
XAC29_RS28910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XAC29_RS28925	COG0587	DNA-directed DNA polymerase activity
XAC29_RS28940	COG1297	OPT oligopeptide transporter protein
XAC29_RS28955	COG0823	Involved in the tonB-independent uptake of proteins
XAC29_RS28955	COG1506	peptidase
XAC29_RS28970	COG1917	Cupin 2, conserved barrel domain protein
XAC29_RS28970	COG2207	Transcriptional regulator
XAC29_RS28985	COG0753	catalase activity
XAC29_RS28990	COG0656	L-ascorbic acid biosynthetic process
XAC29_RS29000	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XAC29_RS29000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XAC29_RS29005	COG2814	Major facilitator Superfamily
XAC29_RS29020	COG2194	sulfuric ester hydrolase activity
XAC29_RS29035	COG0745	RESPONSE REGULATOR receiver
XAC29_RS29040	COG0642	Histidine kinase
XAC29_RS29050	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XAC29_RS29055	COG2894	cell division
XAC29_RS29060	COG0850	regulation of cytokinetic process
XAC29_RS29075	COG4585	Histidine kinase
XAC29_RS29080	COG2197	response regulator
XAC29_RS29095	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XAC29_RS29120	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XAC29_RS29130	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XAC29_RS29150	COG1946	Acyl-CoA thioesterase
XAC29_RS29165	COG0824	Thioesterase
XAC29_RS29170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XAC29_RS29175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XAC29_RS29180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XAC29_RS29185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XAC29_RS29190	COG0268	Binds directly to 16S ribosomal RNA
XAC29_RS29200	COG0196	riboflavin kinase activity
XAC29_RS29205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XAC29_RS29210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XAC29_RS29215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XAC29_RS29230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XAC29_RS29235	COG1845	cytochrome c oxidase, subunit III
XAC29_RS29240	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XAC29_RS29255	COG3152	Membrane
XAC29_RS29265	COG2207	Transcriptional regulator
XAC29_RS29270	COG0326	Molecular chaperone. Has ATPase activity
XAC29_RS29280	COG1366	Belongs to the anti-sigma-factor antagonist family
XAC29_RS29285	COG1366	Belongs to the anti-sigma-factor antagonist family
XAC29_RS29290	COG2172	sigma factor antagonist activity
XAC29_RS29315	COG4771	TonB-dependent receptor
XAC29_RS29325	COG5507	3-demethylubiquinone-9 3-methyltransferase
XAC29_RS29330	COG2205	protein histidine kinase activity
XAC29_RS29340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XAC29_RS29345	COG2205	protein histidine kinase activity
XAC29_RS29345	COG3850	Histidine kinase
XAC29_RS29345	COG4999	Histidine kinase
XAC29_RS29345	COG3437	response regulator, receiver
XAC29_RS29380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XAC29_RS29385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XAC29_RS29400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XAC29_RS29405	COG0228	four-way junction DNA binding
XAC29_RS29410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XAC29_RS29415	COG0336	Belongs to the RNA methyltransferase TrmD family
XAC29_RS29420	COG0335	large ribosomal subunit rRNA binding
XAC29_RS29450	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XAC29_RS29460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XAC29_RS29495	COG3250	beta-galactosidase activity
XAC29_RS29500	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XAC29_RS29520	COG1960	acyl-CoA dehydrogenase activity
XAC29_RS29525	COG1024	Enoyl-CoA hydratase
XAC29_RS29545	COG1250	3-hydroxyacyl-CoA dehydrogenase
XAC29_RS29545	COG1024	Enoyl-CoA hydratase
XAC29_RS29560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XAC29_RS29565	COG0481	GTPase activity
XAC29_RS29580	COG0571	ribonuclease III activity
XAC29_RS29585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XAC29_RS29590	COG1381	Involved in DNA repair and RecF pathway recombination
XAC29_RS29600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XAC29_RS29605	COG2954	triphosphatase activity
XAC29_RS29610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XAC29_RS29620	COG3046	protein related to deoxyribodipyrimidine photolyase
XAC29_RS29625	COG1472	Belongs to the glycosyl hydrolase 3 family
XAC29_RS29630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XAC29_RS29635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XAC29_RS29640	COG1278	Cold shock
XAC29_RS29645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAC29_RS29655	COG1201	RNA secondary structure unwinding
XAC29_RS29660	COG1793	dna ligase
XAC29_RS29670	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XAC29_RS29670	COG1793	dna ligase
XAC29_RS29700	COG0183	Belongs to the thiolase family
XAC29_RS29720	COG1451	nucleotide metabolic process
XAC29_RS29725	COG5487	UPF0391 membrane protein
XAC29_RS29735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XAC29_RS29755	COG1077	Cell shape determining protein MreB Mrl
XAC29_RS29770	COG2824	Alkylphosphonate utilization operon protein PhnA
XAC29_RS29775	COG1902	pentaerythritol trinitrate reductase activity
XAC29_RS29780	COG2814	Major facilitator Superfamily
XAC29_RS29815	COG0392	lysyltransferase activity
XAC29_RS29815	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XAC29_RS29825	COG0251	oxidation-reduction process
XAC29_RS29830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XAC29_RS29845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XAC29_RS29870	COG1595	DNA-templated transcription, initiation
XAC29_RS29890	COG2878	Part of a membrane complex involved in electron transport
XAC29_RS29900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAC29_RS29900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAC29_RS29915	COG1131	(ABC) transporter
XAC29_RS29920	COG0346	lactoylglutathione lyase activity
XAC29_RS29925	COG0833	amino acid
XAC29_RS29930	COG2040	homocysteine
XAC29_RS29940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XAC29_RS29960	COG1695	Transcriptional regulator
XAC29_RS29980	COG1981	membrane
XAC29_RS29995	COG0825	malonyl-CoA metabolic process
XAC29_RS30005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XAC29_RS30010	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAC29_RS30015	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAC29_RS30020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAC29_RS30025	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAC29_RS30040	COG0750	zinc metalloprotease
XAC29_RS30045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XAC29_RS30050	COG0575	Belongs to the CDS family
XAC29_RS30055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XAC29_RS30060	COG0233	cytoplasmic translational termination
XAC29_RS30065	COG0528	UMP kinase activity
XAC29_RS30075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XAC29_RS30080	COG0052	Belongs to the universal ribosomal protein uS2 family
XAC29_RS30120	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XAC29_RS30130	COG1393	Belongs to the ArsC family
XAC29_RS30135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAC29_RS30140	COG0367	asparagine synthase
XAC29_RS30150	COG4774	siderophore transport
XAC29_RS30170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XAC29_RS30200	COG1566	PFAM secretion protein HlyD family protein
XAC29_RS30205	COG2814	Major facilitator Superfamily
XAC29_RS30255	COG0339	signal peptide processing
XAC29_RS30260	COG0386	Belongs to the glutathione peroxidase family
XAC29_RS30315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XAC29_RS30320	COG0084	hydrolase, TatD family'
XAC29_RS30335	COG1960	acyl-CoA dehydrogenase activity
XAC29_RS30355	COG0367	asparagine synthase
XAC29_RS30365	COG0305	Participates in initiation and elongation during chromosome replication
XAC29_RS30370	COG0415	Belongs to the DNA photolyase family
XAC29_RS30380	COG0583	DNA-binding transcription factor activity
XAC29_RS30425	COG3706	GGDEF domain
XAC29_RS30525	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XAC29_RS30540	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAC29_RS30550	COG0497	DNA recombination
XAC29_RS30555	COG1420	regulation of RNA biosynthetic process
XAC29_RS30560	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XAC29_RS30565	COG0443	Heat shock 70 kDa protein
XAC29_RS30570	COG0484	heat shock protein binding
XAC29_RS30580	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XAC29_RS30610	COG0583	DNA-binding transcription factor activity
XAC29_RS30615	COG1132	(ABC) transporter
XAC29_RS30650	COG2850	peptidyl-arginine hydroxylation
XAC29_RS30670	COG1253	flavin adenine dinucleotide binding
XAC29_RS30700	COG1131	(ABC) transporter
XAC29_RS30705	COG1725	Transcriptional regulator
XAC29_RS30710	COG0386	Belongs to the glutathione peroxidase family
XAC29_RS30725	COG2900	Belongs to the SlyX family
XAC29_RS30750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAC29_RS30760	COG0646	methionine synthase
XAC29_RS30760	COG1410	methionine synthase
XAC29_RS30765	COG0646	methionine synthase
XAC29_RS30765	COG1410	methionine synthase
XAC29_RS30770	COG2226	methyltransferase
XAC29_RS30775	COG1960	acyl-CoA dehydrogenase activity
XAC29_RS30790	COG0557	exoribonuclease II activity
XAC29_RS30800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XAC29_RS30810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XAC29_RS30820	COG0704	Plays a role in the regulation of phosphate uptake
XAC29_RS30825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XAC29_RS30830	COG0581	inorganic phosphate transmembrane transporter activity
XAC29_RS30835	COG0573	inorganic phosphate transmembrane transporter activity
XAC29_RS30840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XAC29_RS30870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XAC29_RS30880	COG1024	Enoyl-CoA hydratase
XAC29_RS30890	COG0494	nUDIX hydrolase
XAC29_RS30925	COG0488	(ABC) transporter
XAC29_RS30930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XAC29_RS30930	COG0116	Belongs to the methyltransferase superfamily
XAC29_RS30935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XAC29_RS30960	COG2925	Exonuclease
XAC29_RS30965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAC29_RS30970	COG3844	kynureninase activity
XAC29_RS30980	COG0662	Cupin 2, conserved barrel domain protein
XAC29_RS30985	COG0288	reversible hydration of carbon dioxide
XAC29_RS31045	COG2808	Putative FMN-binding domain
XAC29_RS31065	COG0017	Asparaginyl-tRNA synthetase
XAC29_RS31070	COG0316	Belongs to the HesB IscA family
XAC29_RS31075	COG0360	Binds together with S18 to 16S ribosomal RNA
XAC29_RS31080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XAC29_RS31085	COG0359	binds to the 23S rRNA
XAC29_RS31095	COG3115	cell septum assembly
XAC29_RS31105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAC29_RS31110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XAC29_RS31115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XAC29_RS31125	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XAC29_RS31135	COG4993	Dehydrogenase
XAC29_RS31145	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XAC29_RS31155	COG2986	histidine ammonia-lyase
XAC29_RS31160	COG1228	amidohydrolase
XAC29_RS31195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XAC29_RS31200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XAC29_RS31205	COG0077	Prephenate dehydratase
XAC29_RS31205	COG1605	Chorismate mutase
XAC29_RS31210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XAC29_RS31225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XAC29_RS31230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XAC29_RS31235	COG0583	DNA-binding transcription factor activity
XAC29_RS31270	COG2801	Transposase and inactivated derivatives
XAC29_RS31290	COG0840	transmembrane signaling receptor activity
XAC29_RS31325	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XAC29_RS31330	COG4191	Histidine kinase
XAC29_RS31330	COG0784	Response regulator, receiver
XAC29_RS31345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAC29_RS31355	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XAC29_RS31365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XAC29_RS31380	COG1595	DNA-templated transcription, initiation
XAC29_RS31435	COG2244	polysaccharide biosynthetic process
XAC29_RS31465	COG2264	protein methyltransferase activity
XAC29_RS31475	COG0438	transferase activity, transferring glycosyl groups
XAC29_RS31490	COG1136	(ABC) transporter
XAC29_RS31500	COG0477	Major facilitator Superfamily
XAC29_RS31505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XAC29_RS31520	COG1253	flavin adenine dinucleotide binding
XAC29_RS31530	COG0306	phosphate transporter
XAC29_RS31555	COG0504	CTP synthase activity
XAC29_RS31560	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XAC29_RS31570	COG0148	phosphopyruvate hydratase activity
XAC29_RS31575	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XAC29_RS31580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XAC29_RS31585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XAC29_RS31590	COG0585	pseudouridine synthase activity
XAC29_RS31595	COG2840	Smr protein MutS2
XAC29_RS31600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XAC29_RS31605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XAC29_RS31610	COG1238	metal cluster binding
XAC29_RS31625	COG1534	Rna-binding protein
XAC29_RS31630	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XAC29_RS31640	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XAC29_RS31645	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XAC29_RS31655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XAC29_RS31660	COG1546	Belongs to the CinA family
XAC29_RS31670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XAC29_RS31675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XAC29_RS31680	COG2137	regulation of response to DNA damage stimulus
XAC29_RS31685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XAC29_RS31690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XAC29_RS31705	COG1741	Belongs to the pirin family
XAC29_RS31715	COG0583	DNA-binding transcription factor activity
XAC29_RS31740	COG0351	phosphomethylpyrimidine kinase
XAC29_RS31740	COG0352	thiamine-phosphate diphosphorylase activity
XAC29_RS31755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XAC29_RS31760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XAC29_RS31775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XAC29_RS31785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XAC29_RS31790	COG3734	2-keto-3-deoxy-galactonokinase
XAC29_RS31800	COG4948	Mandelate Racemase Muconate Lactonizing
XAC29_RS31805	COG0800	Aldolase
XAC29_RS31845	COG1501	Belongs to the glycosyl hydrolase 31 family
XAC29_RS31855	COG1070	Carbohydrate kinase
XAC29_RS31860	COG2115	Belongs to the xylose isomerase family
XAC29_RS31865	COG0477	Major facilitator Superfamily
XAC29_RS31875	COG0860	N-Acetylmuramoyl-L-alanine amidase
XAC29_RS31880	COG1469	GTP cyclohydrolase I activity
XAC29_RS31900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XAC29_RS31905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XAC29_RS31910	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XAC29_RS31915	COG0166	Belongs to the GPI family
XAC29_RS31935	COG1472	Belongs to the glycosyl hydrolase 3 family
XAC29_RS31945	COG3706	GGDEF domain
XAC29_RS31945	COG4251	negative regulation of phosphorylation
XAC29_RS31945	COG5001	Diguanylate cyclase
XAC29_RS31945	COG2203	Gaf domain
XAC29_RS31950	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC29_RS31955	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XAC29_RS31965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XAC29_RS31970	COG0671	phosphoesterase, PA-phosphatase related
XAC29_RS31985	COG0697	spore germination
XAC29_RS31990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XAC29_RS31995	COG0167	dihydroorotate dehydrogenase activity
XAC29_RS32025	COG1215	transferase activity, transferring glycosyl groups
XAC29_RS32030	COG1649	PFAM Uncharacterised BCR, COG1649
XAC29_RS32030	COG0726	polysaccharide deacetylase
XAC29_RS32045	COG3210	domain, Protein
XAC29_RS32095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAC29_RS32100	COG0124	histidyl-tRNA synthetase
XAC29_RS32110	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XAC29_RS32115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XAC29_RS32120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAC29_RS32125	COG0131	Imidazoleglycerol-phosphate dehydratase
XAC29_RS32125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XAC29_RS32130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XAC29_RS32135	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XAC29_RS32140	COG0107	imidazoleglycerol-phosphate synthase activity
XAC29_RS32145	COG0140	phosphoribosyl-ATP diphosphatase activity
XAC29_RS32145	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XAC29_RS32160	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XAC29_RS32165	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XAC29_RS32170	COG0235	Class ii aldolase
XAC29_RS32180	COG0531	amino acid
XAC29_RS32190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XAC29_RS32220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XAC29_RS32265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XAC29_RS32270	COG2258	MOSC domain
XAC29_RS32275	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XAC29_RS32280	COG0505	Belongs to the CarA family
XAC29_RS32290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XAC29_RS32295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAC29_RS32305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XAC29_RS32350	COG3279	Response regulator of the LytR AlgR family
XAC29_RS32355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XAC29_RS32360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XAC29_RS32370	COG2205	protein histidine kinase activity
XAC29_RS32370	COG2198	Histidine kinase
XAC29_RS32370	COG0784	Response regulator, receiver
XAC29_RS32375	COG1024	Enoyl-CoA hydratase
XAC29_RS32380	COG0318	PFAM AMP-dependent synthetase and ligase
XAC29_RS32410	COG2267	carboxylic ester hydrolase activity
XAC29_RS32420	COG2201	protein-glutamate methylesterase activity
XAC29_RS32425	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XAC29_RS32435	COG0840	transmembrane signaling receptor activity
XAC29_RS32445	COG0835	chemotaxis
XAC29_RS32455	COG0840	transmembrane signaling receptor activity
XAC29_RS32460	COG0840	transmembrane signaling receptor activity
XAC29_RS32475	COG0840	transmembrane signaling receptor activity
XAC29_RS32485	COG0840	transmembrane signaling receptor activity
XAC29_RS32490	COG0840	transmembrane signaling receptor activity
XAC29_RS32495	COG0840	transmembrane signaling receptor activity
XAC29_RS32500	COG0840	transmembrane signaling receptor activity
XAC29_RS32515	COG0840	transmembrane signaling receptor activity
XAC29_RS32540	COG0643	Histidine kinase
XAC29_RS32540	COG2198	Histidine kinase
XAC29_RS32545	COG0745	RESPONSE REGULATOR receiver
XAC29_RS32555	COG0835	chemotaxis
XAC29_RS32565	COG1360	Flagellar Motor Protein
XAC29_RS32570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XAC29_RS32645	COG0641	radical SAM
XAC29_RS32660	COG0784	Response regulator, receiver
XAC29_RS32660	COG2198	Histidine kinase
XAC29_RS32660	COG0643	Histidine kinase
XAC29_RS32690	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XAC29_RS32720	COG1684	flagellar biosynthetic protein fliR
XAC29_RS32735	COG3190	flagellar
XAC29_RS32785	COG1677	Flagellar hook-basal body complex protein FliE
XAC29_RS32815	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS32820	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS32825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAC29_RS32845	COG2201	protein-glutamate methylesterase activity
XAC29_RS32875	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XAC29_RS32880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XAC29_RS32885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XAC29_RS32895	COG3951	Flagellar rod assembly protein muramidase FlgJ
XAC29_RS32895	COG1705	Flagellar rod assembly protein muramidase FlgJ
XAC29_RS32900	COG1706	bacterial-type flagellum-dependent cell motility
XAC29_RS32905	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XAC29_RS32915	COG4787	bacterial-type flagellum-dependent cell motility
XAC29_RS32925	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XAC29_RS32930	COG1558	bacterial-type flagellum-dependent cell motility
XAC29_RS32940	COG0835	chemotaxis
XAC29_RS32940	COG0784	Response regulator, receiver
XAC29_RS32960	COG5002	protein histidine kinase activity
XAC29_RS32990	COG2915	High frequency lysogenization protein hflD homolog
XAC29_RS32995	COG0482	sulfurtransferase activity
XAC29_RS33010	COG0542	response to heat
XAC29_RS33020	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XAC29_RS33030	COG0492	ferredoxin-NADP+ reductase activity
XAC29_RS33035	COG1674	ftsk spoiiie
XAC29_RS33045	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XAC29_RS33055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XAC29_RS33060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XAC29_RS33070	COG0183	Belongs to the thiolase family
XAC29_RS33075	COG1250	3-hydroxyacyl-CoA dehydrogenase
XAC29_RS33075	COG1024	Enoyl-CoA hydratase
XAC29_RS33090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XAC29_RS33100	COG1426	Protein conserved in bacteria
XAC29_RS33110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAC29_RS33115	COG1160	GTP binding
XAC29_RS33120	COG1160	GTP binding
XAC29_RS33125	COG0303	'Molybdopterin
XAC29_RS33130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XAC29_RS33165	COG0708	Exodeoxyribonuclease III
XAC29_RS33175	COG0303	'Molybdopterin
XAC29_RS33180	COG0746	molybdenum cofactor guanylyltransferase activity
XAC29_RS33195	COG1914	H( )-stimulated, divalent metal cation uptake system
XAC29_RS33210	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XAC29_RS33215	COG0668	transmembrane transport
XAC29_RS33225	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XAC29_RS33240	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS33245	COG1183	phosphatidylcholine synthase activity
XAC29_RS33255	COG3243	poly(R)-hydroxyalkanoic acid synthase
XAC29_RS33270	COG0723	plastoquinol--plastocyanin reductase activity
XAC29_RS33270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC29_RS33280	COG2183	response to ionizing radiation
XAC29_RS33285	COG2205	protein histidine kinase activity
XAC29_RS33285	COG0784	Response regulator, receiver
XAC29_RS33350	COG0800	Aldolase
XAC29_RS33355	COG0129	dihydroxy-acid dehydratase activity
XAC29_RS33360	COG0363	glucosamine-6-phosphate deaminase activity
XAC29_RS33365	COG0837	glucose binding
XAC29_RS33370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XAC29_RS33390	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XAC29_RS33405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XAC29_RS33410	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XAC29_RS33420	COG4591	ABC-type transport system involved in lipoprotein release permease component
XAC29_RS33425	COG1136	(ABC) transporter
XAC29_RS33440	COG0811	peptide transport
XAC29_RS33450	COG1132	(ABC) transporter
XAC29_RS33455	COG1663	tetraacyldisaccharide 4'-kinase activity
XAC29_RS33460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XAC29_RS33465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XAC29_RS33475	COG0322	excinuclease ABC activity
XAC29_RS33480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XAC29_RS33500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XAC29_RS33505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XAC29_RS33525	COG2801	Transposase and inactivated derivatives
XAC29_RS33535	COG0582	viral genome integration into host DNA
XAC29_RS33545	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XAC29_RS33565	COG1054	Belongs to the UPF0176 family
XAC29_RS33575	COG1530	ribonuclease E activity
XAC29_RS33585	COG3064	Membrane
XAC29_RS33590	COG0428	transporter
XAC29_RS33600	COG2154	pterin-4-alpha-carbinolamine dehydratase
XAC29_RS33605	COG0316	Belongs to the HesB IscA family
XAC29_RS33605	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XAC29_RS33650	COG2226	methyltransferase
XAC29_RS33650	COG1073	alpha beta
XAC29_RS33660	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS33675	COG2801	Transposase and inactivated derivatives
XAC29_RS33690	COG1238	metal cluster binding
XAC29_RS33725	COG3279	Response regulator of the LytR AlgR family
XAC29_RS33770	COG4566	intracellular signal transduction
XAC29_RS33780	COG5001	Diguanylate cyclase
XAC29_RS33795	COG3685	Protein conserved in bacteria
XAC29_RS33815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XAC29_RS33815	COG1648	precorrin-2 dehydrogenase activity
XAC29_RS33830	COG2814	Major facilitator Superfamily
XAC29_RS33850	COG1335	isochorismatase
XAC29_RS33865	COG2197	response regulator
XAC29_RS33885	COG0583	DNA-binding transcription factor activity
XAC29_RS33890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XAC29_RS33895	COG3002	Belongs to the UPF0753 family
XAC29_RS33900	COG2801	Transposase and inactivated derivatives
XAC29_RS33915	COG5489	Protein of unknown function (DUF736)
XAC29_RS33920	COG2003	Belongs to the UPF0758 family
XAC29_RS33945	COG0582	viral genome integration into host DNA
XAC29_RS33960	COG4774	siderophore transport
XAC29_RS33975	COG2336	PFAM SpoVT AbrB
XAC29_RS34000	COG4206	TonB-dependent receptor
XAC29_RS34020	COG2273	Hydrolase Family 16
XAC29_RS34020	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XAC29_RS34040	COG2274	protein secretion by the type I secretion system
XAC29_RS34095	COG0270	DNA (cytosine-5-)-methyltransferase activity
XAC29_RS34145	COG4804	nuclease activity
XAC29_RS34155	COG2801	Transposase and inactivated derivatives
XAC29_RS34160	COG5006	permease, DMT superfamily
XAC29_RS34175	COG2249	NAD(P)H dehydrogenase (quinone) activity
XAC29_RS34185	COG3938	Belongs to the proline racemase family
XAC29_RS34200	COG2807	transmembrane transport
XAC29_RS34205	COG2207	Transcriptional regulator
XAC29_RS34355	COG0210	DNA helicase
XAC29_RS34435	COG2084	Dehydrogenase
XAC29_RS34455	COG2003	Belongs to the UPF0758 family
XAC29_RS34485	COG0582	viral genome integration into host DNA
XAC29_RS34490	COG0519	Catalyzes the synthesis of GMP from XMP
XAC29_RS34490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XAC29_RS34500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XAC29_RS34510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XAC29_RS34510	COG0475	glutathione-regulated potassium exporter activity
XAC29_RS34515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XAC29_RS34525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XAC29_RS34530	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XAC29_RS34540	COG0776	regulation of translation
XAC29_RS34545	COG0539	negative regulation of cytoplasmic translation
XAC29_RS34550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XAC29_RS34565	COG2957	Belongs to the agmatine deiminase family
XAC29_RS34570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XAC29_RS34595	COG0395	ABC-type sugar transport system, permease component
XAC29_RS34600	COG1175	transmembrane transport
XAC29_RS34630	COG2350	Protein conserved in bacteria
XAC29_RS34635	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XAC29_RS34640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XAC29_RS34645	COG1187	pseudouridine synthase activity
XAC29_RS34665	COG0436	Aminotransferase
XAC29_RS34690	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XAC29_RS34695	COG1138	Cytochrome C-type biogenesis protein
XAC29_RS34720	COG1278	Cold shock
XAC29_RS34725	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XAC29_RS34730	COG4988	ABC transporter
XAC29_RS34740	COG1294	oxidase, subunit
XAC29_RS34765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XAC29_RS34770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XAC29_RS34780	COG0165	Argininosuccinate lyase
XAC29_RS34785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XAC29_RS34795	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XAC29_RS34800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAC29_RS34810	COG0137	argininosuccinate synthase activity
XAC29_RS34815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XAC29_RS34825	COG0215	cysteine-tRNA ligase activity
XAC29_RS34830	COG2166	iron-sulfur cluster assembly
XAC29_RS34850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XAC29_RS34855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XAC29_RS34880	COG4302	ethanolamine ammonia-lyase activity
XAC29_RS34910	COG2963	transposase activity
XAC29_RS34930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XAC29_RS34935	COG0402	S-adenosylhomocysteine deaminase activity
XAC29_RS34945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XAC29_RS34950	COG1509	lysine 2,3-aminomutase activity
XAC29_RS34970	COG0483	inositol monophosphate 1-phosphatase activity
XAC29_RS34975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XAC29_RS34990	COG0488	(ABC) transporter
XAC29_RS34995	COG0513	Belongs to the DEAD box helicase family
XAC29_RS35000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XAC29_RS35005	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XAC29_RS35015	COG0625	glutathione transferase activity
XAC29_RS35025	COG4681	YaeQ
XAC29_RS35030	COG2081	HI0933 family
XAC29_RS35040	COG0501	Belongs to the peptidase M48B family
XAC29_RS35045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAC29_RS35050	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS35070	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XAC29_RS35080	COG0802	atpase or kinase
XAC29_RS35090	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XAC29_RS35095	COG1570	exodeoxyribonuclease VII activity
XAC29_RS35105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XAC29_RS35275	COG0835	chemotaxis
XAC29_RS35280	COG0840	transmembrane signaling receptor activity
XAC29_RS35285	COG2094	Belongs to the DNA glycosylase MPG family
XAC29_RS35290	COG1201	RNA secondary structure unwinding
XAC29_RS35305	COG2969	positive regulation of protein catabolic process
XAC29_RS35310	COG0625	glutathione transferase activity
XAC29_RS35315	COG2857	Cytochrome c1
XAC29_RS35320	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XAC29_RS35325	COG0723	plastoquinol--plastocyanin reductase activity
XAC29_RS35330	COG0741	lytic transglycosylase activity
XAC29_RS35345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XAC29_RS35350	COG1702	phosphate starvation-inducible protein PhoH
XAC29_RS35360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XAC29_RS35370	COG4535	Mg2 and Co2 transporter CorC
XAC29_RS35385	COG1012	belongs to the aldehyde dehydrogenase family
XAC29_RS35395	COG1177	transmembrane transport
XAC29_RS35400	COG1176	ABC-type spermidine putrescine transport system, permease component I
XAC29_RS35405	COG3842	ATPase activity
XAC29_RS35425	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XAC29_RS35440	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XAC29_RS35445	COG0174	glutamine synthetase
XAC29_RS35450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC29_RS35460	COG2703	oxygen carrier activity
XAC29_RS35465	COG0477	Major facilitator Superfamily
XAC29_RS35475	COG0243	molybdopterin cofactor binding
XAC29_RS35480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XAC29_RS35485	COG2223	nitrite transmembrane transporter activity
XAC29_RS35495	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XAC29_RS35505	COG2733	membrane
XAC29_RS35520	COG0477	Major facilitator Superfamily
XAC29_RS35535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC29_RS35540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAC29_RS35545	COG1609	Transcriptional regulator
XAC29_RS35550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XAC29_RS35550	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAC29_RS35555	COG1105	Belongs to the carbohydrate kinase PfkB family
XAC29_RS35560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XAC29_RS35560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XAC29_RS35605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XAC29_RS35615	COG1862	Preprotein translocase
XAC29_RS35620	COG0343	queuine tRNA-ribosyltransferase activity
XAC29_RS35625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XAC29_RS35665	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XAC29_RS35670	COG3291	Pkd domain containing protein
XAC29_RS35685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XAC29_RS35700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XAC29_RS35705	COG0742	ribosomal rna small subunit methyltransferase
XAC29_RS35710	COG0326	Molecular chaperone. Has ATPase activity
XAC29_RS35785	COG0531	amino acid
XAC29_RS35800	COG0006	proline dipeptidase activity
XAC29_RS35810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XAC29_RS35825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC29_RS35830	COG3938	Belongs to the proline racemase family
XAC29_RS35840	COG0552	protein localization to endoplasmic reticulum
XAC29_RS35845	COG1194	a g-specific adenine glycosylase
XAC29_RS35850	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XAC29_RS35855	COG0784	Response regulator, receiver
XAC29_RS35855	COG4191	Histidine kinase
XAC29_RS35870	COG0322	excinuclease ABC activity
XAC29_RS35885	COG3040	lipid binding
XAC29_RS35895	COG1960	acyl-CoA dehydrogenase activity
XAC29_RS35905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XAC29_RS35925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAC29_RS35930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAC29_RS35960	COG0438	transferase activity, transferring glycosyl groups
XAC29_RS35970	COG0438	transferase activity, transferring glycosyl groups
XAC29_RS35975	COG0438	transferase activity, transferring glycosyl groups
XAC29_RS36025	COG0072	phenylalanine-tRNA ligase activity
XAC29_RS36025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAC29_RS36030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XAC29_RS36045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XAC29_RS36050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XAC29_RS36075	COG1082	Xylose isomerase domain protein TIM barrel
XAC29_RS36090	COG0366	Alpha amylase catalytic
XAC29_RS36095	COG2963	transposase activity
XAC29_RS36170	COG2948	multi-organism process
XAC29_RS36190	COG3505	Type IV secretory pathway VirD4
XAC29_RS36205	COG0556	nucleotide-excision repair
XAC29_RS36275	COG4695	Portal protein
XAC29_RS36320	COG3179	chitinase
XAC29_RS36370	COG2801	Transposase and inactivated derivatives
XAC29_RS36415	COG3275	phosphorelay sensor kinase activity
XAC29_RS36420	COG1611	Belongs to the LOG family
XAC29_RS36430	COG2095	MarC family integral membrane protein
XAC29_RS36440	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XAC29_RS36475	COG1185	polyribonucleotide nucleotidyltransferase activity
XAC29_RS36480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XAC29_RS36485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XAC29_RS36490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XAC29_RS36495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XAC29_RS36500	COG0195	Participates in both transcription termination and antitermination
XAC29_RS36505	COG0779	Required for maturation of 30S ribosomal subunits
XAC29_RS36515	COG1007	ATP synthesis coupled electron transport
XAC29_RS36540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC29_RS36550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC29_RS36555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XAC29_RS36565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XAC29_RS36570	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XAC29_RS36575	COG0649	NAD binding
XAC29_RS36580	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC29_RS36585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC29_RS36590	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC29_RS36605	COG0149	triose-phosphate isomerase activity
XAC29_RS36610	COG0300	oxidoreductase activity
XAC29_RS36645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XAC29_RS36650	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XAC29_RS36655	COG0159	tryptophan synthase activity
XAC29_RS36665	COG0133	tryptophan synthase activity
XAC29_RS36675	COG0135	phosphoribosylanthranilate isomerase activity
XAC29_RS36680	COG0101	tRNA pseudouridine synthase activity
XAC29_RS36700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XAC29_RS36705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XAC29_RS36710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XAC29_RS36715	COG2890	protein-(glutamine-N5) methyltransferase activity
XAC29_RS36725	COG0688	phosphatidylethanolamine metabolic process
XAC29_RS36735	COG0433	COG0433 Predicted ATPase
XAC29_RS36740	COG0494	nUDIX hydrolase
XAC29_RS36755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAC29_RS36760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XAC29_RS36785	COG0717	Belongs to the dCTP deaminase family
XAC29_RS36790	COG0489	protein tyrosine kinase activity
XAC29_RS36810	COG3590	peptidase
XAC29_RS36815	COG3590	peptidase
XAC29_RS36840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC29_RS36845	COG2311	Membrane
XAC29_RS36850	COG1047	Peptidyl-prolyl cis-trans
XAC29_RS36855	COG0791	NLP P60 protein
XAC29_RS36860	COG0791	NLP P60 protein
XAC29_RS36870	COG4106	trans-aconitate 2-methyltransferase activity
XAC29_RS36875	COG1301	dicarboxylic acid transport
XAC29_RS36880	COG1785	Belongs to the alkaline phosphatase family
XAC29_RS36885	COG0037	tRNA processing
XAC29_RS36890	COG1722	exodeoxyribonuclease VII activity
XAC29_RS36895	COG0142	geranyltranstransferase activity
XAC29_RS36900	COG4104	PAAR repeat-containing protein
XAC29_RS36910	COG0312	modulator of DNA gyrase
XAC29_RS36915	COG3028	Belongs to the UPF0307 family
XAC29_RS36920	COG0312	modulator of DNA gyrase
XAC29_RS36930	COG3164	Protein of unknown function
XAC29_RS36940	COG0424	maF-like protein
XAC29_RS36945	COG2968	Membrane
XAC29_RS36960	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XAC29_RS36975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XAC29_RS36980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XAC29_RS36995	COG0495	leucyl-tRNA aminoacylation
XAC29_RS37005	COG3118	belongs to the thioredoxin family
XAC29_RS37030	COG2155	Conserved Protein
XAC29_RS37075	COG1132	(ABC) transporter
XAC29_RS37105	COG0745	RESPONSE REGULATOR receiver
XAC29_RS37110	COG5000	phosphorelay sensor kinase activity
XAC29_RS37110	COG5002	protein histidine kinase activity
XAC29_RS37115	COG0475	glutathione-regulated potassium exporter activity
XAC29_RS37125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XAC29_RS37150	COG1187	pseudouridine synthase activity
XAC29_RS37155	COG5001	Diguanylate cyclase
XAC29_RS37155	COG5002	protein histidine kinase activity
XAC29_RS37205	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XAC29_RS37270	COG0667	Aldo Keto reductase
XAC29_RS37275	COG2814	Major facilitator Superfamily
XAC29_RS37280	COG0583	DNA-binding transcription factor activity
XAC29_RS37290	COG2207	Transcriptional regulator
XAC29_RS37300	COG1309	transcriptional regulator
XAC29_RS37325	COG0735	belongs to the Fur family
XAC29_RS37330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAC29_RS37355	COG4452	Inner membrane protein CreD
XAC29_RS37365	COG2205	protein histidine kinase activity
XAC29_RS37370	COG0745	RESPONSE REGULATOR receiver
XAC29_RS37375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XAC29_RS37385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XAC29_RS37420	COG2198	Histidine kinase
XAC29_RS37420	COG0643	Histidine kinase
XAC29_RS37425	COG0840	transmembrane signaling receptor activity
XAC29_RS37430	COG0835	chemotaxis
XAC29_RS37435	COG2199	diguanylate cyclase activity
XAC29_RS37435	COG2202	Pas domain
XAC29_RS37435	COG2200	EAL domain
XAC29_RS37440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XAC29_RS37445	COG2201	protein-glutamate methylesterase activity
XAC29_RS37450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC29_RS37455	COG3590	peptidase
XAC29_RS37465	COG0588	phosphoglycerate mutase activity
XAC29_RS37470	COG1515	deoxyribonuclease V activity
XAC29_RS37480	COG1741	Belongs to the pirin family
XAC29_RS37495	COG1741	Belongs to the pirin family
XAC29_RS37500	COG1966	Carbon starvation protein
XAC29_RS37505	COG2879	small protein
XAC29_RS37555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XAC29_RS37560	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XAC29_RS37565	COG2080	2 iron, 2 sulfur cluster binding
XAC29_RS37575	COG5001	Diguanylate cyclase
XAC29_RS37575	COG4251	negative regulation of phosphorylation
XAC29_RS37575	COG2203	Gaf domain
XAC29_RS37575	COG3706	GGDEF domain
XAC29_RS37580	COG0629	single-stranded DNA binding
XAC29_RS37585	COG0142	geranyltranstransferase activity
XAC29_RS37595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XAC29_RS37610	COG0527	aspartate kinase activity
XAC29_RS37615	COG0384	phenazine biosynthesis protein PhzF
XAC29_RS37620	COG0384	phenazine biosynthesis protein PhzF
XAC29_RS37630	COG1764	response to oxidative stress
XAC29_RS37635	COG0540	Belongs to the ATCase OTCase family
XAC29_RS37640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XAC29_RS37645	COG1678	Uncharacterized ACR, COG1678
XAC29_RS37655	COG0519	Catalyzes the synthesis of GMP from XMP
XAC29_RS37670	COG5297	Belongs to the glycosyl hydrolase family 6
XAC29_RS37685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XAC29_RS37700	COG0739	heme binding
XAC29_RS37720	COG0693	protein deglycase activity
XAC29_RS37730	COG1959	2 iron, 2 sulfur cluster binding
XAC29_RS37735	COG0719	Fe-S assembly protein
XAC29_RS37740	COG0396	ATPase activity
XAC29_RS37745	COG0719	Fe-S assembly protein
XAC29_RS37750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XAC29_RS37760	COG2146	nitrite reductase [NAD(P)H] activity
XAC29_RS37765	COG4774	siderophore transport
XAC29_RS37770	COG3128	pkhd-type hydroxylase
XAC29_RS37795	COG1477	protein flavinylation
XAC29_RS37800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XAC29_RS37815	COG1555	photosystem II stabilization
XAC29_RS37820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAC29_RS37830	COG3178	'Phosphotransferase
XAC29_RS37835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XAC29_RS37845	COG0628	permease
XAC29_RS37855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XAC29_RS37865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XAC29_RS37885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XAC29_RS37890	COG0271	Belongs to the BolA IbaG family
XAC29_RS37900	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XAC29_RS37910	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XAC29_RS37915	COG1137	ATPase activity
XAC29_RS37930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAC29_RS37935	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XAC29_RS37940	COG1660	Displays ATPase and GTPase activities
XAC29_RS37950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAC29_RS37955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XAC29_RS37960	COG2239	Acts as a magnesium transporter
XAC29_RS37970	COG1294	oxidase, subunit
XAC29_RS37975	COG1271	oxidase subunit
XAC29_RS37985	COG1113	amino acid transport
XAC29_RS38005	COG2197	response regulator
XAC29_RS38010	COG0531	amino acid
XAC29_RS38030	COG1234	tRNA 3'-trailer cleavage
XAC29_RS38065	COG2814	Major facilitator Superfamily
XAC29_RS38075	COG0754	glutathionylspermidine amidase activity
XAC29_RS38100	COG1842	Phage shock protein A
XAC29_RS38110	COG0259	pyridoxamine-phosphate oxidase activity
XAC29_RS38115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XAC29_RS38120	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XAC29_RS38205	COG2814	Major facilitator Superfamily
XAC29_RS38225	COG2198	Histidine kinase
XAC29_RS38225	COG2205	protein histidine kinase activity
XAC29_RS38225	COG0784	Response regulator, receiver
XAC29_RS38230	COG2353	YceI-like domain
XAC29_RS38250	COG1760	l-serine dehydratase
XAC29_RS38265	COG0460	homoserine dehydrogenase
XAC29_RS38265	COG0527	aspartate kinase activity
XAC29_RS38275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAC29_RS38280	COG0739	heme binding
XAC29_RS38285	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XAC29_RS38290	COG1272	protein, Hemolysin III
XAC29_RS38295	COG2982	Protein involved in outer membrane biogenesis
XAC29_RS38300	COG0517	IMP dehydrogenase activity
XAC29_RS38300	COG0516	GMP reductase activity
XAC29_RS38305	COG0463	Glycosyl transferase, family 2
XAC29_RS38310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XAC29_RS38315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XAC29_RS38325	COG4771	TonB-dependent receptor
XAC29_RS38335	COG1309	transcriptional regulator
XAC29_RS38345	COG1960	acyl-CoA dehydrogenase activity
XAC29_RS38370	COG0509	glycine decarboxylation via glycine cleavage system
XAC29_RS38375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XAC29_RS38385	COG0330	HflC and HflK could
XAC29_RS38390	COG1742	UPF0060 membrane protein
XAC29_RS38395	COG3956	TIGRFAM MazG family protein
XAC29_RS38405	COG0494	nUDIX hydrolase
XAC29_RS38415	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XAC29_RS38420	COG0837	glucose binding
XAC29_RS38435	COG3858	chitin binding
XAC29_RS38435	COG1388	LysM domain
XAC29_RS38440	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XAC29_RS38450	COG1472	Belongs to the glycosyl hydrolase 3 family
XAC29_RS38465	COG0531	amino acid
XAC29_RS38475	COG1486	melibiose metabolic process
XAC29_RS38485	COG3537	Alpha-1,2-mannosidase
XAC29_RS38520	COG3142	Participates in the control of copper homeostasis
XAC29_RS38525	COG1446	asparaginase
XAC29_RS38550	COG2198	Histidine kinase
XAC29_RS38550	COG0784	Response regulator, receiver
XAC29_RS38550	COG0643	Histidine kinase
XAC29_RS38555	COG0840	transmembrane signaling receptor activity
XAC29_RS38560	COG0835	chemotaxis
XAC29_RS38575	COG0189	ligase activity
XAC29_RS38585	COG1397	ADP-ribosylglycohydrolase
XAC29_RS38595	COG1199	ATP-dependent helicase activity
XAC29_RS38605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XAC29_RS38610	COG1215	transferase activity, transferring glycosyl groups
XAC29_RS38620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XAC29_RS38625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XAC29_RS38630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XAC29_RS38635	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XAC29_RS38640	COG0535	radical SAM domain protein
XAC29_RS38645	COG0535	radical SAM domain protein
XAC29_RS38660	COG0837	glucose binding
XAC29_RS38670	COG1643	Atp-dependent helicase
XAC29_RS38675	COG0783	Belongs to the Dps family
XAC29_RS38680	COG0514	ATP-dependent DNA helicase (RecQ)
XAC29_RS38715	COG0840	transmembrane signaling receptor activity
XAC29_RS38735	COG3920	Histidine kinase
XAC29_RS38740	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XAC29_RS38750	COG0602	queuosine metabolic process
XAC29_RS38760	COG2885	chlorophyll binding
XAC29_RS38765	COG0823	Involved in the tonB-independent uptake of proteins
XAC29_RS38775	COG0848	biopolymer transport protein
XAC29_RS38785	COG0824	Thioesterase
XAC29_RS38790	COG2255	four-way junction helicase activity
XAC29_RS38800	COG3158	transport of potassium into the cell
XAC29_RS38805	COG0632	four-way junction helicase activity
XAC29_RS38810	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XAC29_RS38815	COG0217	transcriptional regulatory protein
XAC29_RS38830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XAC29_RS38845	COG0477	Major facilitator Superfamily
XAC29_RS38880	COG0488	(ABC) transporter
XAC29_RS38915	COG4651	solute:proton antiporter activity
XAC29_RS38915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XAC29_RS38940	COG4772	TonB-dependent receptor
XAC29_RS38950	COG4264	IucA IucC family
XAC29_RS38965	COG0019	diaminopimelate decarboxylase activity
XAC29_RS38990	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XAC29_RS39000	COG1492	cobalamin metabolic process
XAC29_RS39010	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XAC29_RS39030	COG4206	TonB-dependent receptor
XAC29_RS39035	COG0542	response to heat
XAC29_RS39040	COG1116	anion transmembrane transporter activity
XAC29_RS39045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XAC29_RS39050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XAC29_RS39055	COG0667	Aldo Keto reductase
XAC29_RS39060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XAC29_RS39065	COG4771	TonB-dependent receptor
XAC29_RS39070	COG2827	Endonuclease containing a URI domain
XAC29_RS39110	COG1877	trehalose-phosphatase activity
XAC29_RS39115	COG3387	PFAM Glycoside hydrolase 15-related
XAC29_RS39130	COG0840	transmembrane signaling receptor activity
XAC29_RS39135	COG3011	Protein conserved in bacteria
XAC29_RS39150	COG0564	pseudouridine synthase activity
XAC29_RS39155	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAC29_RS39165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XAC29_RS39165	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XAC29_RS39210	COG2951	lytic endotransglycosylase activity
XAC29_RS39215	COG4644	lycopene metabolic process
XAC29_RS39240	COG2369	cell adhesion
XAC29_RS39260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XAC29_RS39265	COG0045	succinate-CoA ligase (ADP-forming) activity
XAC29_RS39280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XAC29_RS39310	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XAC29_RS39345	COG5002	protein histidine kinase activity
XAC29_RS39350	COG0745	RESPONSE REGULATOR receiver
XAC29_RS39360	COG0189	ligase activity
XAC29_RS39420	COG2003	Belongs to the UPF0758 family
XAC29_RS39445	COG0784	Response regulator, receiver
XAC29_RS39445	COG4191	Histidine kinase
XAC29_RS39450	COG0784	Response regulator, receiver
XAC29_RS39450	COG4191	Histidine kinase
XAC29_RS39560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XAC29_RS39585	COG2022	thiamine diphosphate biosynthetic process
XAC29_RS39590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XAC29_RS39595	COG0471	metal ion transport
XAC29_RS39595	COG3273	potassium ion transport
XAC29_RS39615	COG1970	mechanosensitive ion channel activity
XAC29_RS39640	COG3250	beta-galactosidase activity
XAC29_RS39645	COG4948	Mandelate Racemase Muconate Lactonizing
XAC29_RS39660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XAC29_RS39670	COG0308	aminopeptidase N
XAC29_RS39680	COG2801	Transposase and inactivated derivatives
XAC29_RS39715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAC29_RS39725	COG2895	sulfate adenylyltransferase (ATP) activity
XAC29_RS39725	COG0529	Catalyzes the synthesis of activated sulfate
XAC29_RS39730	COG0175	sulfate reduction
XAC29_RS39735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XAC29_RS39740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XAC29_RS39745	COG0175	sulfate reduction
XAC29_RS39765	COG2205	protein histidine kinase activity
XAC29_RS39765	COG2198	Histidine kinase
XAC29_RS39765	COG0784	Response regulator, receiver
XAC29_RS39800	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XAC29_RS39805	COG3588	fructose-bisphosphate aldolase
XAC29_RS39810	COG0469	pyruvate kinase activity
XAC29_RS39820	COG0126	phosphoglycerate kinase activity
XAC29_RS39840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XAC29_RS39850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XAC29_RS39855	COG3047	cAMP biosynthetic process
XAC29_RS39860	COG3047	cAMP biosynthetic process
XAC29_RS39870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAC29_RS39870	COG3453	Protein conserved in bacteria
XAC29_RS39875	COG0725	ABC transporter, periplasmic molybdate-binding protein
XAC29_RS39880	COG4149	molybdate abc transporter
XAC29_RS39885	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XAC29_RS39920	COG1376	ErfK ybiS ycfS ynhG family protein
XAC29_RS39925	COG0739	heme binding
XAC29_RS39935	COG4773	Receptor
XAC29_RS39955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XAC29_RS39960	COG1301	dicarboxylic acid transport
XAC29_RS39970	COG2304	oxidoreductase activity
XAC29_RS39990	COG0714	Associated with various cellular activities
XAC29_RS40020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XAC29_RS40045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XAC29_RS40055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XAC29_RS40065	COG0194	GDP metabolic process
XAC29_RS40070	COG1561	YicC-like family, N-terminal region
XAC29_RS40075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XAC29_RS40085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XAC29_RS40090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XAC29_RS40105	COG0006	proline dipeptidase activity
XAC29_RS40115	COG0006	proline dipeptidase activity
XAC29_RS40120	COG3079	Belongs to the UPF0149 family
XAC29_RS40135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XAC29_RS40145	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XAC29_RS40155	COG2912	Transglutaminase-like superfamily
XAC29_RS40160	COG1773	rubredoxin
XAC29_RS40165	COG0352	thiamine-phosphate diphosphorylase activity
XAC29_RS40180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XAC29_RS40195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAC29_RS40230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAC29_RS40235	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS40245	COG0671	phosphoesterase, PA-phosphatase related
XAC29_RS40250	COG3781	membrane
XAC29_RS40260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XAC29_RS40265	COG0563	adenylate kinase activity
XAC29_RS40290	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XAC29_RS40310	COG3710	Transcriptional regulator
XAC29_RS40315	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XAC29_RS40325	COG0840	transmembrane signaling receptor activity
XAC29_RS40330	COG0405	Gamma-glutamyltransferase
XAC29_RS40335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XAC29_RS40355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XAC29_RS40360	COG0473	3-isopropylmalate dehydrogenase activity
XAC29_RS40365	COG0066	3-isopropylmalate dehydratase activity
XAC29_RS40370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XAC29_RS40390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XAC29_RS40395	COG1538	Outer membrane efflux protein
XAC29_RS40400	COG1519	Transferase
XAC29_RS40405	COG1560	Kdo2-lipid A biosynthetic process
XAC29_RS40430	COG0281	malic enzyme
XAC29_RS40430	COG0280	phosphate acetyltransferase
XAC29_RS40435	COG1301	dicarboxylic acid transport
XAC29_RS40460	COG0583	DNA-binding transcription factor activity
XAC29_RS40480	COG2197	response regulator
XAC29_RS40490	COG0642	Histidine kinase
XAC29_RS40505	COG2851	Citrate transporter
XAC29_RS40510	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS40515	COG1609	Transcriptional regulator
XAC29_RS40520	COG2211	Major facilitator Superfamily
XAC29_RS40545	COG1162	GTPase activity
XAC29_RS40565	COG4773	Receptor
XAC29_RS40570	COG0726	polysaccharide deacetylase
XAC29_RS40575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XAC29_RS40590	COG2963	transposase activity
XAC29_RS40595	COG2801	Transposase and inactivated derivatives
XAC29_RS40610	COG1307	EDD domain protein, DegV family
XAC29_RS40615	COG0242	peptide deformylase activity
XAC29_RS40635	COG0457	Tetratricopeptide repeat
XAC29_RS40640	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XAC29_RS40645	COG1215	transferase activity, transferring glycosyl groups
XAC29_RS40650	COG1215	transferase activity, transferring glycosyl groups
XAC29_RS40665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XAC29_RS40720	COG2188	Transcriptional regulator
XAC29_RS40730	COG1450	Type ii and iii secretion system protein
XAC29_RS40745	COG3166	PFAM Fimbrial assembly family protein
XAC29_RS40750	COG3156	type II secretion system protein K
XAC29_RS40755	COG4795	General secretion pathway protein
XAC29_RS40760	COG2165	general secretion pathway protein
XAC29_RS40765	COG4970	Tfp pilus assembly protein FimT
XAC29_RS40770	COG2165	general secretion pathway protein
XAC29_RS40775	COG1459	type II secretion system
XAC29_RS40780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XAC29_RS40785	COG1404	Belongs to the peptidase S8 family
XAC29_RS40795	COG1404	Belongs to the peptidase S8 family
XAC29_RS40800	COG5295	Hep Hag repeat protein
XAC29_RS40810	COG0047	phosphoribosylformylglycinamidine synthase activity
XAC29_RS40810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XAC29_RS40815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XAC29_RS40820	COG4974	Belongs to the 'phage' integrase family
XAC29_RS40835	COG0795	lipopolysaccharide-transporting ATPase activity
XAC29_RS40845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XAC29_RS40860	COG0525	valine-tRNA ligase activity
XAC29_RS40890	COG1183	phosphatidylcholine synthase activity
XAC29_RS40900	COG0442	prolyl-tRNA aminoacylation
XAC29_RS40915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XAC29_RS40920	COG1127	ABC transporter
XAC29_RS40925	COG3218	ABC-type transport auxiliary lipoprotein component
XAC29_RS40925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XAC29_RS40960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XAC29_RS40965	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XAC29_RS40965	COG0662	Cupin 2, conserved barrel domain protein
XAC29_RS40995	COG2086	electron transfer activity
XAC29_RS41010	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XAC29_RS41010	COG0546	phosphoglycolate phosphatase activity
XAC29_RS41015	COG0277	FAD linked oxidase domain protein
XAC29_RS41030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAC29_RS41060	COG1216	Glycosyl transferase, family 2
XAC29_RS41060	COG0438	transferase activity, transferring glycosyl groups
XAC29_RS41080	COG0626	cystathionine gamma-synthase activity
XAC29_RS41115	COG0625	glutathione transferase activity
XAC29_RS41125	COG0513	Belongs to the DEAD box helicase family
XAC29_RS41135	COG4206	TonB-dependent receptor
XAC29_RS41140	COG0720	synthase
XAC29_RS41150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XAC29_RS41160	COG1956	GAF domain-containing protein
XAC29_RS41170	COG2819	hydrolase of the alpha beta superfamily
XAC29_RS41185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XAC29_RS41190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAC29_RS41205	COG0339	signal peptide processing
XAC29_RS41255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XAC29_RS41260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC29_RS41265	COG1136	(ABC) transporter
XAC29_RS41265	COG4591	ABC-type transport system involved in lipoprotein release permease component
XAC29_RS41270	COG0577	efflux transmembrane transporter activity
XAC29_RS41270	COG1136	(ABC) transporter
XAC29_RS41275	COG0577	efflux transmembrane transporter activity
XAC29_RS41290	COG4191	Histidine kinase
XAC29_RS41295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XAC29_RS41310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XAC29_RS41315	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XAC29_RS41320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XAC29_RS41325	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XAC29_RS41330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XAC29_RS41335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XAC29_RS41345	COG0356	it plays a direct role in the translocation of protons across the membrane
XAC29_RS41365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XAC29_RS41375	COG0508	dehydrogenase complex catalyzes the overall conversion of
XAC29_RS41420	COG2011	ABC-type metal ion transport system permease component
XAC29_RS41425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XAC29_RS41430	COG0697	spore germination
XAC29_RS41435	COG1666	GTP binding
XAC29_RS41445	COG0784	Response regulator, receiver
XAC29_RS41445	COG2198	Histidine kinase
XAC29_RS41445	COG5002	protein histidine kinase activity
XAC29_RS41470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XAC29_RS41475	COG1187	pseudouridine synthase activity
XAC29_RS41480	COG2813	Specifically methylates the guanine in position
XAC29_RS41500	COG2202	Pas domain
XAC29_RS41500	COG2205	protein histidine kinase activity
XAC29_RS41520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XAC29_RS41525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC29_RS41580	COG0842	Transport permease protein
XAC29_RS41585	COG1131	(ABC) transporter
XAC29_RS41590	COG0025	NhaP-type Na H and K H
XAC29_RS41595	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XAC29_RS41600	COG1573	uracil-dna glycosylase
XAC29_RS41610	COG3384	dioxygenase
XAC29_RS41620	COG0583	DNA-binding transcription factor activity
XAC29_RS41630	COG0667	Aldo Keto reductase
XAC29_RS41640	COG3590	peptidase
XAC29_RS41660	COG0531	amino acid
XAC29_RS41675	COG2972	Histidine kinase
XAC29_RS41690	COG3685	Protein conserved in bacteria
XAC29_RS41695	COG3546	catalase activity
XAC29_RS41740	COG1271	oxidase subunit
XAC29_RS41745	COG1294	oxidase, subunit
XAC29_RS41760	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS41765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XAC29_RS41785	COG1132	(ABC) transporter
XAC29_RS41800	COG1063	alcohol dehydrogenase
XAC29_RS41875	COG0251	oxidation-reduction process
XAC29_RS41905	COG0840	transmembrane signaling receptor activity
XAC29_RS41925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XAC29_RS41965	COG0024	Methionine aminopeptidase
XAC29_RS41985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XAC29_RS41990	COG1490	D-aminoacyl-tRNA deacylase activity
XAC29_RS41995	COG1560	Kdo2-lipid A biosynthetic process
XAC29_RS42045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XAC29_RS42045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XAC29_RS42050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XAC29_RS42055	COG0242	peptide deformylase activity
XAC29_RS42060	COG1652	LysM domain
XAC29_RS42065	COG0758	DNA mediated transformation
XAC29_RS42070	COG2922	Belongs to the Smg family
XAC29_RS42085	COG1754	DNA topoisomerase type I activity
XAC29_RS42085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XAC29_RS42090	COG0009	L-threonylcarbamoyladenylate synthase
XAC29_RS42105	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS42115	COG0616	signal peptide processing
XAC29_RS42120	COG0534	Mate efflux family protein
XAC29_RS42145	COG0625	glutathione transferase activity
XAC29_RS42160	COG1252	NADH dehydrogenase
XAC29_RS42165	COG2860	membrane
XAC29_RS42170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XAC29_RS42175	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XAC29_RS42180	COG2201	protein-glutamate methylesterase activity
XAC29_RS42185	COG2177	Part of the ABC transporter FtsEX involved in
XAC29_RS42190	COG2884	Cell division ATP-binding protein ftsE
XAC29_RS42195	COG0513	Belongs to the DEAD box helicase family
XAC29_RS42200	COG3118	belongs to the thioredoxin family
XAC29_RS42205	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XAC29_RS42210	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XAC29_RS42215	COG0583	DNA-binding transcription factor activity
XAC29_RS42260	COG1518	maintenance of DNA repeat elements
XAC29_RS42265	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
XAC29_RS42275	COG1652	LysM domain
XAC29_RS42280	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XAC29_RS42280	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XAC29_RS42285	COG1473	amidohydrolase
XAC29_RS42290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC29_RS42295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAC29_RS42305	COG5383	Protein conserved in bacteria
XAC29_RS42345	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XAC29_RS42350	COG3023	N-Acetylmuramoyl-L-alanine amidase
XAC29_RS42360	COG4948	Mandelate Racemase Muconate Lactonizing
XAC29_RS42370	COG0531	amino acid
XAC29_RS42385	COG4682	membrane
XAC29_RS42390	COG2133	pyrroloquinoline quinone binding
XAC29_RS42400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XAC29_RS42405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XAC29_RS42415	COG1610	YqeY-like protein
XAC29_RS42420	COG1295	ribonuclease BN
XAC29_RS42425	COG0358	DNA primase activity
XAC29_RS42440	COG0109	protoheme IX farnesyltransferase activity
XAC29_RS42470	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XAC29_RS42485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XAC29_RS42525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XAC29_RS42530	COG0739	heme binding
XAC29_RS42535	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XAC29_RS42545	COG2223	nitrite transmembrane transporter activity
XAC29_RS42550	COG0708	Exodeoxyribonuclease III
XAC29_RS42555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XAC29_RS42565	COG1192	Involved in chromosome partitioning
XAC29_RS42570	COG1475	DNA binding
XAC29_RS42585	COG0463	Glycosyl transferase, family 2
XAC29_RS42605	COG0756	dUTP diphosphatase activity
XAC29_RS42610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XAC29_RS42615	COG2003	Belongs to the UPF0758 family
XAC29_RS42620	COG0018	arginyl-trna synthetase
XAC29_RS42635	COG4221	oxidoreductase activity
XAC29_RS42640	COG2755	lipolytic protein G-D-S-L family
XAC29_RS42640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XAC29_RS42660	COG1166	arginine decarboxylase activity
XAC29_RS42665	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XAC29_RS42705	COG0606	chelatase, subunit chli
XAC29_RS42720	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XAC29_RS42755	COG1690	Belongs to the RtcB family
XAC29_RS42795	COG1090	epimerase
XAC29_RS42805	COG0642	Histidine kinase
XAC29_RS42825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XAC29_RS42850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XAC29_RS42855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XAC29_RS42870	COG0753	catalase activity
XAC29_RS42885	COG2197	response regulator
XAC29_RS42890	COG4585	Histidine kinase
XAC29_RS42895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC29_RS42900	COG1136	(ABC) transporter
XAC29_RS42925	COG0697	spore germination
XAC29_RS42940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAC29_RS42945	COG0180	Tryptophanyl-tRNA synthetase
XAC29_RS42950	COG3237	CsbD-like
XAC29_RS42990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XAC29_RS43005	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XAC29_RS43050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XAC29_RS43090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XAC29_RS43150	COG0625	glutathione transferase activity
XAC29_RS43190	COG4555	ABC transporter
XAC29_RS43200	COG1476	TRANSCRIPTIONal
XAC29_RS43245	COG0633	Ferredoxin
XAC29_RS43245	COG0543	2 iron, 2 sulfur cluster binding
XAC29_RS43250	COG1131	(ABC) transporter
XAC29_RS43255	COG0842	Transport permease protein
XAC29_RS43265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XAC29_RS43295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XAC29_RS43300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XAC29_RS43310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XAC29_RS43310	COG1042	CoA-binding domain protein
XAC29_RS43310	COG0045	succinate-CoA ligase (ADP-forming) activity
XAC29_RS43315	COG2239	Acts as a magnesium transporter
XAC29_RS43320	COG3338	carbonate dehydratase activity
XAC29_RS43330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XAC29_RS43335	COG3387	PFAM Glycoside hydrolase 15-related
XAC29_RS43350	COG3100	YcgL domain-containing protein
XAC29_RS43355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XAC29_RS43365	COG0463	Glycosyl transferase, family 2
XAC29_RS43380	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS43415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAC29_RS43430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XAC29_RS43455	COG4946	Tricorn protease homolog
XAC29_RS43455	COG1506	peptidase
XAC29_RS43455	COG0823	Involved in the tonB-independent uptake of proteins
XAC29_RS43470	COG0408	coproporphyrinogen oxidase activity
XAC29_RS43505	COG0515	serine threonine protein kinase
XAC29_RS43505	COG2815	serine threonine protein kinase
XAC29_RS43510	COG0631	protein serine/threonine phosphatase activity
XAC29_RS43665	COG0210	DNA helicase
XAC29_RS43680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC29_RS43685	COG0583	DNA-binding transcription factor activity
XAC29_RS43690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XAC29_RS43700	COG2159	amidohydrolase
XAC29_RS43720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC29_RS43740	COG0357	Ribosomal RNA small subunit methyltransferase G
XAC29_RS43745	COG3540	Alkaline phosphatase
XAC29_RS43755	COG2091	lysine biosynthetic process via aminoadipic acid
XAC29_RS43775	COG0708	Exodeoxyribonuclease III
XAC29_RS43780	COG1940	carbohydrate kinase activity
XAC29_RS43780	COG1846	Transcriptional regulator
XAC29_RS43790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAC29_RS43800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XAC29_RS43805	COG3162	membrane
XAC29_RS43815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XAC29_RS43845	COG3507	Belongs to the glycosyl hydrolase 43 family
XAC29_RS43865	COG1028	Short-chain dehydrogenase reductase Sdr
XAC29_RS43870	COG0179	Fumarylacetoacetate (FAA) hydrolase
XAC29_RS43875	COG4948	Mandelate Racemase Muconate Lactonizing
XAC29_RS43885	COG3254	rhamnose metabolic process
XAC29_RS43890	COG0738	Major facilitator superfamily
XAC29_RS43895	COG1414	Transcriptional regulator
XAC29_RS43900	COG1971	Probably functions as a manganese efflux pump
XAC29_RS43910	COG2205	protein histidine kinase activity
XAC29_RS43925	COG3459	Glycosyltransferase 36 associated
XAC29_RS43930	COG2211	Major facilitator Superfamily
XAC29_RS43935	COG3265	gluconokinase activity
XAC29_RS43940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAC29_RS43960	COG2911	Protein conserved in bacteria
XAC29_RS43965	COG0729	surface antigen
XAC29_RS44005	COG0752	glycyl-tRNA synthetase alpha subunit
XAC29_RS44010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XAC29_RS44020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XAC29_RS44020	COG0519	Catalyzes the synthesis of GMP from XMP
XAC29_RS44030	COG0805	protein transport
XAC29_RS44035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XAC29_RS44040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XAC29_RS44050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XAC29_RS44070	COG2974	May be involved in recombination
XAC29_RS44075	COG0037	tRNA processing
XAC29_RS44080	COG2115	Belongs to the xylose isomerase family
XAC29_RS44090	COG3661	Belongs to the glycosyl hydrolase 67 family
XAC29_RS44100	COG4948	Mandelate Racemase Muconate Lactonizing
XAC29_RS44110	COG1472	Belongs to the glycosyl hydrolase 3 family
XAC29_RS44115	COG0246	Mannitol dehydrogenase
XAC29_RS44195	COG3386	PFAM SMP-30 Gluconolaconase
XAC29_RS44205	COG3250	beta-galactosidase activity
XAC29_RS44210	COG1904	glucuronate isomerase
XAC29_RS44215	COG3693	PFAM glycoside hydrolase, family 10
XAC29_RS44230	COG3693	PFAM glycoside hydrolase, family 10
XAC29_RS44245	COG2211	Major facilitator Superfamily
XAC29_RS44290	COG2937	Belongs to the GPAT DAPAT family
XAC29_RS44325	COG0284	orotidine-5'-phosphate decarboxylase activity
XAC29_RS44330	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XAC29_RS44335	COG3132	Protein of unknown function, DUF480
XAC29_RS44350	COG0210	DNA helicase
XAC29_RS44355	COG1435	thymidine kinase activity
XAC29_RS44365	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XAC29_RS44375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XAC29_RS44405	COG3135	benzoate transporter
XAC29_RS44425	COG0676	glucose-6-phosphate 1-epimerase activity
XAC29_RS44435	COG3012	SEC-C Motif Domain Protein
XAC29_RS44440	COG0730	response to heat
XAC29_RS44460	COG0302	gtp cyclohydrolase
XAC29_RS44475	COG1566	PFAM secretion protein HlyD family protein
XAC29_RS44485	COG1289	transmembrane transporter activity
XAC29_RS44490	COG0477	Major facilitator Superfamily
XAC29_RS44500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC29_RS44520	COG4691	Plasmid stability protein
XAC29_RS44525	COG1487	ribonuclease activity
XAC29_RS44550	COG0564	pseudouridine synthase activity
XAC29_RS44570	COG0439	Biotin carboxylase
XAC29_RS44605	COG1074	ATP-dependent DNA helicase activity
XAC29_RS44610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XAC29_RS44625	COG1127	ABC transporter
XAC29_RS44630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XAC29_RS44635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XAC29_RS44650	COG2853	Lipoprotein
XAC29_RS44660	COG0386	Belongs to the glutathione peroxidase family
XAC29_RS44670	COG1322	Protein conserved in bacteria
XAC29_RS44675	COG0604	alcohol dehydrogenase
XAC29_RS44690	COG0625	glutathione transferase activity
XAC29_RS44700	COG0531	amino acid
XAC29_RS44705	COG3537	Alpha-1,2-mannosidase
XAC29_RS44720	COG3835	regulator
XAC29_RS44725	COG1929	Belongs to the glycerate kinase type-1 family
XAC29_RS44730	COG2271	Major facilitator Superfamily
XAC29_RS44745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XAC29_RS44750	COG0861	Integral membrane protein TerC family
XAC29_RS44760	COG0584	glycerophosphoryl diester phosphodiesterase
XAC29_RS44775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XAC29_RS44780	COG0726	polysaccharide deacetylase
XAC29_RS44790	COG0706	membrane insertase activity
XAC29_RS44795	COG0594	ribonuclease P activity
XAC29_RS44945	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC29_RS44955	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC29_RS44965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC29_RS45000	COG0493	'glutamate synthase
XAC29_RS45015	COG0067	glutamate synthase
XAC29_RS45015	COG0069	glutamate synthase activity
XAC29_RS45015	COG0070	glutamate synthase
XAC29_RS45150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XAC29_RS45335	COG1064	alcohol dehydrogenase