locus-tag	class	description
XAC_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XAC_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XAC_RS00025	COG0187	DNA topoisomerase II activity
XAC_RS00035	COG0501	Belongs to the peptidase M48B family
XAC_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XAC_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC_RS00120	COG0793	Belongs to the peptidase S41A family
XAC_RS00125	COG4942	peptidase
XAC_RS00135	COG2234	aminopeptidase activity
XAC_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC_RS00165	COG1064	alcohol dehydrogenase
XAC_RS00170	COG0493	'glutamate synthase
XAC_RS00175	COG0070	glutamate synthase
XAC_RS00175	COG0069	glutamate synthase activity
XAC_RS00175	COG0067	glutamate synthase
XAC_RS00220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
XAC_RS00235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XAC_RS00240	COG0438	transferase activity, transferring glycosyl groups
XAC_RS00240	COG0297	glycogen (starch) synthase activity
XAC_RS00260	COG0367	asparagine synthase
XAC_RS00290	COG1132	(ABC) transporter
XAC_RS00320	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XAC_RS00405	COG1111	helicase
XAC_RS00405	COG1205	dead DEAH box helicase
XAC_RS00410	COG1272	protein, Hemolysin III
XAC_RS00425	COG0300	oxidoreductase activity
XAC_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS00450	COG2249	NAD(P)H dehydrogenase (quinone) activity
XAC_RS00510	COG3237	CsbD-like
XAC_RS00560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAC_RS00570	COG0477	Major facilitator Superfamily
XAC_RS00610	COG0714	Associated with various cellular activities
XAC_RS00640	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XAC_RS00650	COG4772	TonB-dependent receptor
XAC_RS00660	COG0662	Cupin 2, conserved barrel domain protein
XAC_RS00665	COG1012	belongs to the aldehyde dehydrogenase family
XAC_RS00690	COG1304	FMN binding
XAC_RS00705	COG4585	Histidine kinase
XAC_RS00710	COG2197	response regulator
XAC_RS00730	COG3710	Transcriptional regulator
XAC_RS00735	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XAC_RS00805	COG2801	Transposase and inactivated derivatives
XAC_RS00810	COG0366	Alpha amylase catalytic
XAC_RS00815	COG0366	Alpha amylase catalytic
XAC_RS00820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAC_RS00840	COG0657	acetylesterase activity
XAC_RS00840	COG2755	lipolytic protein G-D-S-L family
XAC_RS00850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XAC_RS00865	COG3507	Belongs to the glycosyl hydrolase 43 family
XAC_RS00870	COG1609	Transcriptional regulator
XAC_RS00875	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XAC_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS00890	COG2755	lipolytic protein G-D-S-L family
XAC_RS00905	COG3186	Phenylalanine-4-hydroxylase
XAC_RS00910	COG1522	sequence-specific DNA binding
XAC_RS00920	COG1752	Esterase of the alpha-beta hydrolase superfamily
XAC_RS00930	COG1119	ATPase activity
XAC_RS00945	COG1125	glycine betaine transport
XAC_RS00960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XAC_RS00980	COG1396	sequence-specific DNA binding
XAC_RS01005	COG0489	protein tyrosine kinase activity
XAC_RS01010	COG2062	phosphohistidine phosphatase, SixA
XAC_RS01020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC_RS01065	COG1968	undecaprenyl-diphosphatase activity
XAC_RS01070	COG0174	glutamine synthetase
XAC_RS01075	COG0347	Belongs to the P(II) protein family
XAC_RS01080	COG0004	ammonium transporteR
XAC_RS01085	COG3852	Histidine kinase
XAC_RS01090	COG2204	response regulator
XAC_RS01095	COG2032	superoxide dismutase activity
XAC_RS01100	COG2032	superoxide dismutase activity
XAC_RS01105	COG0346	lactoylglutathione lyase activity
XAC_RS01115	COG0183	Belongs to the thiolase family
XAC_RS01150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XAC_RS01155	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XAC_RS01160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XAC_RS01170	COG0028	Belongs to the TPP enzyme family
XAC_RS01175	COG2205	protein histidine kinase activity
XAC_RS01200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XAC_RS01215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAC_RS01225	COG0596	Alpha beta hydrolase
XAC_RS01230	COG0727	PFAM Uncharacterised protein family (UPF0153)
XAC_RS01235	COG0318	PFAM AMP-dependent synthetase and ligase
XAC_RS01240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAC_RS01250	COG1181	Belongs to the D-alanine--D-alanine ligase family
XAC_RS01260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XAC_RS01270	COG0564	pseudouridine synthase activity
XAC_RS01295	COG0339	signal peptide processing
XAC_RS01325	COG0475	glutathione-regulated potassium exporter activity
XAC_RS01330	COG0583	DNA-binding transcription factor activity
XAC_RS01335	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XAC_RS01340	COG2224	Isocitrate lyase
XAC_RS01370	COG4770	biotin carboxylase activity
XAC_RS01375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XAC_RS01380	COG1960	acyl-CoA dehydrogenase activity
XAC_RS01435	COG0523	cobalamin synthesis protein
XAC_RS01450	COG0697	spore germination
XAC_RS01460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XAC_RS01465	COG1846	Transcriptional regulator
XAC_RS01470	COG1764	response to oxidative stress
XAC_RS01500	COG2130	NADP-dependent
XAC_RS01515	COG1187	pseudouridine synthase activity
XAC_RS01530	COG1643	Atp-dependent helicase
XAC_RS01540	COG4807	Protein conserved in bacteria
XAC_RS01545	COG2351	hydroxyisourate hydrolase activity
XAC_RS01550	COG2072	flavoprotein involved in K transport
XAC_RS01570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XAC_RS01605	COG1957	nucleoside hydrolase
XAC_RS01615	COG2252	PERMEase
XAC_RS01640	COG0084	hydrolase, TatD family'
XAC_RS01655	COG0583	DNA-binding transcription factor activity
XAC_RS01660	COG2814	Major facilitator Superfamily
XAC_RS01675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XAC_RS01680	COG1902	pentaerythritol trinitrate reductase activity
XAC_RS01700	COG0745	RESPONSE REGULATOR receiver
XAC_RS01705	COG2205	protein histidine kinase activity
XAC_RS01710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC_RS01730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XAC_RS01735	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XAC_RS01740	COG0583	DNA-binding transcription factor activity
XAC_RS01775	COG0702	epimerase
XAC_RS01780	COG1733	regulation of RNA biosynthetic process
XAC_RS01805	COG2801	Transposase and inactivated derivatives
XAC_RS01820	COG0129	dihydroxy-acid dehydratase activity
XAC_RS01840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XAC_RS01895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XAC_RS01900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XAC_RS01925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XAC_RS01930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XAC_RS01940	COG3485	protocatechuate 3,4-dioxygenase
XAC_RS01945	COG3485	protocatechuate 3,4-dioxygenase
XAC_RS01955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAC_RS01960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XAC_RS01970	COG1414	Transcriptional regulator
XAC_RS01980	COG0657	acetylesterase activity
XAC_RS01990	COG0445	tRNA wobble uridine modification
XAC_RS02000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XAC_RS02030	COG2267	carboxylic ester hydrolase activity
XAC_RS02040	COG0156	8-amino-7-oxononanoate synthase activity
XAC_RS02045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XAC_RS02050	COG1040	competence protein
XAC_RS02055	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XAC_RS02130	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XAC_RS02200	COG3264	Mechanosensitive ion channel
XAC_RS02200	COG1511	domain protein
XAC_RS02205	COG1368	sulfuric ester hydrolase activity
XAC_RS02210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XAC_RS02215	COG2354	Protein conserved in bacteria
XAC_RS02225	COG0297	glycogen (starch) synthase activity
XAC_RS02230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAC_RS02235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAC_RS02260	COG0702	epimerase
XAC_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS02300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAC_RS02305	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS02315	COG0513	Belongs to the DEAD box helicase family
XAC_RS02335	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XAC_RS02345	COG3483	tryptophan 2,3-dioxygenase activity
XAC_RS02350	COG3104	oligopeptide transport
XAC_RS02370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XAC_RS02385	COG1320	monovalent cation:proton antiporter activity
XAC_RS02390	COG2212	antiporter activity
XAC_RS02400	COG0651	ATP synthesis coupled electron transport
XAC_RS02405	COG1006	Multisubunit Na H antiporter MnhC subunit
XAC_RS02410	COG2111	Na H antiporter
XAC_RS02410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XAC_RS02430	COG3179	chitinase
XAC_RS02450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XAC_RS02455	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XAC_RS02470	COG0456	acetyltransferase
XAC_RS02475	COG1597	lipid kinase activity
XAC_RS02500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XAC_RS02505	COG0134	indole-3-glycerol-phosphate synthase activity
XAC_RS02515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAC_RS02520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XAC_RS02530	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XAC_RS02540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XAC_RS02555	COG1051	belongs to the nudix hydrolase family
XAC_RS02595	COG0316	Belongs to the HesB IscA family
XAC_RS02620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XAC_RS02640	COG2814	Major facilitator Superfamily
XAC_RS02645	COG0583	DNA-binding transcription factor activity
XAC_RS02650	COG2814	Major facilitator Superfamily
XAC_RS02655	COG1289	transmembrane transporter activity
XAC_RS02665	COG0151	Belongs to the GarS family
XAC_RS02675	COG0138	bifunctional purine biosynthesis protein purh
XAC_RS02680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XAC_RS02685	COG2267	carboxylic ester hydrolase activity
XAC_RS02690	COG0671	phosphoesterase, PA-phosphatase related
XAC_RS02690	COG2453	phosphatase
XAC_RS02715	COG4589	Belongs to the CDS family
XAC_RS02720	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XAC_RS02745	COG2264	protein methyltransferase activity
XAC_RS02760	COG0439	Biotin carboxylase
XAC_RS02770	COG0511	ligase activity, forming carbon-carbon bonds
XAC_RS02775	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XAC_RS02785	COG1324	tolerance protein
XAC_RS02810	COG0300	oxidoreductase activity
XAC_RS02815	COG2356	endonuclease I
XAC_RS02825	COG0459	protein refolding
XAC_RS02840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XAC_RS02855	COG3386	PFAM SMP-30 Gluconolaconase
XAC_RS02865	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XAC_RS02870	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XAC_RS02890	COG0778	Nitroreductase
XAC_RS02895	COG2353	YceI-like domain
XAC_RS02925	COG3052	prosthetic group binding
XAC_RS02950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XAC_RS02960	COG1802	Transcriptional regulator
XAC_RS03005	COG2801	Transposase and inactivated derivatives
XAC_RS03015	COG4221	oxidoreductase activity
XAC_RS03030	COG4221	oxidoreductase activity
XAC_RS03040	COG0435	Glutathione S-transferase
XAC_RS03065	COG2409	Drug exporters of the RND superfamily
XAC_RS03070	COG0823	Involved in the tonB-independent uptake of proteins
XAC_RS03070	COG1506	peptidase
XAC_RS03110	COG0697	spore germination
XAC_RS03125	COG1113	amino acid transport
XAC_RS03145	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XAC_RS03180	COG5001	Diguanylate cyclase
XAC_RS03185	COG0840	transmembrane signaling receptor activity
XAC_RS03190	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC_RS03190	COG5297	Belongs to the glycosyl hydrolase family 6
XAC_RS03195	COG0659	secondary active sulfate transmembrane transporter activity
XAC_RS03215	COG2943	transferase activity, transferring hexosyl groups
XAC_RS03225	COG3275	phosphorelay sensor kinase activity
XAC_RS03235	COG0181	hydroxymethylbilane synthase activity
XAC_RS03260	COG1505	serine-type exopeptidase activity
XAC_RS03265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XAC_RS03270	COG0436	Aminotransferase
XAC_RS03280	COG2832	Protein of unknown function (DUF454)
XAC_RS03290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XAC_RS03300	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XAC_RS03305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XAC_RS03310	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XAC_RS03335	COG2226	methyltransferase
XAC_RS03340	COG5001	Diguanylate cyclase
XAC_RS03340	COG3300	MHYT domain
XAC_RS03345	COG0308	aminopeptidase N
XAC_RS03395	COG3284	Transcriptional regulator
XAC_RS03400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAC_RS03405	COG1077	Cell shape determining protein MreB Mrl
XAC_RS03410	COG1792	Involved in formation and maintenance of cell shape
XAC_RS03425	COG0772	Belongs to the SEDS family
XAC_RS03435	COG2951	lytic endotransglycosylase activity
XAC_RS03440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XAC_RS03450	COG1686	Belongs to the peptidase S11 family
XAC_RS03460	COG2921	Belongs to the UPF0250 family
XAC_RS03465	COG0321	lipoyl(octanoyl) transferase activity
XAC_RS03470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XAC_RS03485	COG0583	DNA-binding transcription factor activity
XAC_RS03495	COG1051	belongs to the nudix hydrolase family
XAC_RS03495	COG1056	cytidyltransferase-related domain
XAC_RS03530	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XAC_RS03535	COG0673	inositol 2-dehydrogenase activity
XAC_RS03540	COG2823	Periplasmic or secreted lipoprotein
XAC_RS03545	COG4251	negative regulation of phosphorylation
XAC_RS03550	COG0784	Response regulator, receiver
XAC_RS03555	COG4191	Histidine kinase
XAC_RS03560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XAC_RS03615	COG1459	type II secretion system
XAC_RS03680	COG2188	Transcriptional regulator
XAC_RS03690	COG1609	Transcriptional regulator
XAC_RS03695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XAC_RS03700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XAC_RS03710	COG0617	tRNA 3'-terminal CCA addition
XAC_RS03715	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XAC_RS03720	COG1012	belongs to the aldehyde dehydrogenase family
XAC_RS03725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XAC_RS03735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XAC_RS03750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XAC_RS03755	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XAC_RS03770	COG2205	protein histidine kinase activity
XAC_RS03800	COG3791	Glutathione-dependent formaldehyde-activating
XAC_RS03815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XAC_RS03825	COG0697	spore germination
XAC_RS03835	COG0488	(ABC) transporter
XAC_RS03845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XAC_RS03850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XAC_RS03860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XAC_RS03860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XAC_RS03880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XAC_RS03885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XAC_RS03890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XAC_RS03910	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XAC_RS03915	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XAC_RS03920	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XAC_RS03925	COG2205	protein histidine kinase activity
XAC_RS03930	COG0745	RESPONSE REGULATOR receiver
XAC_RS03945	COG0277	FAD linked oxidase domain protein
XAC_RS03950	COG1988	membrane-bound metal-dependent
XAC_RS03955	COG0792	nuclease activity
XAC_RS03985	COG0275	rRNA processing
XAC_RS03990	COG3116	cell division
XAC_RS04000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XAC_RS04005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XAC_RS04010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XAC_RS04020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XAC_RS04025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XAC_RS04030	COG1181	Belongs to the D-alanine--D-alanine ligase family
XAC_RS04035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XAC_RS04050	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XAC_RS04060	COG0739	heme binding
XAC_RS04065	COG0653	protein targeting
XAC_RS04070	COG0494	nUDIX hydrolase
XAC_RS04080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XAC_RS04090	COG0604	alcohol dehydrogenase
XAC_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS04090	COG3321	synthase
XAC_RS04110	COG0366	Alpha amylase catalytic
XAC_RS04140	COG2226	methyltransferase
XAC_RS04145	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XAC_RS04155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XAC_RS04190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XAC_RS04200	COG4106	trans-aconitate 2-methyltransferase activity
XAC_RS04205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XAC_RS04215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAC_RS04220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XAC_RS04225	COG0667	Aldo Keto reductase
XAC_RS04235	COG4771	TonB-dependent receptor
XAC_RS04255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XAC_RS04260	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XAC_RS04270	COG2175	clavaminate synthase activity
XAC_RS04280	COG4181	ATPase activity
XAC_RS04295	COG0642	Histidine kinase
XAC_RS04305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XAC_RS04325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XAC_RS04330	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XAC_RS04345	COG3829	transcription factor binding
XAC_RS04355	COG1116	anion transmembrane transporter activity
XAC_RS04360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XAC_RS04370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XAC_RS04375	COG0431	NADPH-dependent FMN reductase
XAC_RS04400	COG0747	negative chemotaxis
XAC_RS04410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XAC_RS04420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XAC_RS04425	COG2967	ApaG domain
XAC_RS04430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XAC_RS04435	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XAC_RS04440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAC_RS04445	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XAC_RS04455	COG0123	including yeast histone deacetylase and acetoin utilization protein
XAC_RS04460	COG2096	Adenosyltransferase
XAC_RS04470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAC_RS04475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAC_RS04505	COG3384	dioxygenase
XAC_RS04510	COG0583	DNA-binding transcription factor activity
XAC_RS04525	COG1024	Enoyl-CoA hydratase
XAC_RS04545	COG3386	PFAM SMP-30 Gluconolaconase
XAC_RS04555	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XAC_RS04580	COG0697	spore germination
XAC_RS04590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAC_RS04610	COG2205	protein histidine kinase activity
XAC_RS04610	COG5002	protein histidine kinase activity
XAC_RS04610	COG0784	Response regulator, receiver
XAC_RS04615	COG2197	response regulator
XAC_RS04625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XAC_RS04635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XAC_RS04640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAC_RS04645	COG0583	DNA-binding transcription factor activity
XAC_RS04650	COG3634	alkyl hydroperoxide reductase activity
XAC_RS04660	COG2890	protein-(glutamine-N5) methyltransferase activity
XAC_RS04680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAC_RS04680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAC_RS04710	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XAC_RS04740	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XAC_RS04755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XAC_RS04760	COG1404	Belongs to the peptidase S8 family
XAC_RS04765	COG1404	Belongs to the peptidase S8 family
XAC_RS04770	COG1404	Belongs to the peptidase S8 family
XAC_RS04775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XAC_RS04800	COG1295	ribonuclease BN
XAC_RS04805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAC_RS04810	COG1254	Belongs to the acylphosphatase family
XAC_RS04825	COG0521	Mo-molybdopterin cofactor biosynthetic process
XAC_RS04835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XAC_RS04840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XAC_RS04850	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XAC_RS04855	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XAC_RS04865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XAC_RS04870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XAC_RS04875	COG0193	aminoacyl-tRNA hydrolase activity
XAC_RS04880	COG0012	GTP binding
XAC_RS04900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XAC_RS04915	COG0250	Participates in transcription elongation, termination and antitermination
XAC_RS04920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XAC_RS04925	COG0081	regulation of translation
XAC_RS04930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XAC_RS04935	COG0222	ribosome binding
XAC_RS04940	COG0085	RNA polymerase activity
XAC_RS04945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XAC_RS04950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XAC_RS04955	COG0049	tRNA binding
XAC_RS04960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XAC_RS04965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XAC_RS04970	COG0051	transcription antitermination factor activity, RNA binding
XAC_RS04975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XAC_RS04980	COG0088	Forms part of the polypeptide exit tunnel
XAC_RS04985	COG0089	rRNA binding
XAC_RS04990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XAC_RS04995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XAC_RS05005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XAC_RS05010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XAC_RS05015	COG0255	Belongs to the universal ribosomal protein uL29 family
XAC_RS05020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XAC_RS05030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XAC_RS05035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XAC_RS05045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XAC_RS05050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XAC_RS05055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XAC_RS05065	COG1841	ribosomal large subunit assembly
XAC_RS05070	COG0200	Binds to the 23S rRNA
XAC_RS05075	COG0201	protein transport
XAC_RS05100	COG0203	ribosomal protein L17
XAC_RS05105	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XAC_RS05120	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XAC_RS05130	COG0154	amidase activity
XAC_RS05140	COG1217	gtp-binding protein TYPA
XAC_RS05145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XAC_RS05150	COG0039	L-malate dehydrogenase activity
XAC_RS05155	COG0625	glutathione transferase activity
XAC_RS05165	COG0446	pyridine nucleotide-disulphide oxidoreductase
XAC_RS05165	COG1902	pentaerythritol trinitrate reductase activity
XAC_RS05170	COG0604	alcohol dehydrogenase
XAC_RS05195	COG0156	8-amino-7-oxononanoate synthase activity
XAC_RS05200	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XAC_RS05205	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XAC_RS05210	COG4208	sulfate ABC transporter
XAC_RS05215	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XAC_RS05225	COG1063	alcohol dehydrogenase
XAC_RS05255	COG0406	alpha-ribazole phosphatase activity
XAC_RS05260	COG0285	dihydrofolate synthase activity
XAC_RS05280	COG2833	Protein of unknown function (DUF455)
XAC_RS05290	COG3291	Pkd domain containing protein
XAC_RS05300	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAC_RS05305	COG0671	phosphoesterase, PA-phosphatase related
XAC_RS05310	COG0438	transferase activity, transferring glycosyl groups
XAC_RS05320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XAC_RS05335	COG4783	chaperone-mediated protein folding
XAC_RS05350	COG0473	3-isopropylmalate dehydrogenase activity
XAC_RS05480	COG2801	Transposase and inactivated derivatives
XAC_RS05495	COG3852	Histidine kinase
XAC_RS05505	COG0544	peptidyl-prolyl cis-trans isomerase activity
XAC_RS05515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XAC_RS05545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAC_RS05555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAC_RS05565	COG0328	RNA-DNA hybrid ribonuclease activity
XAC_RS05570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XAC_RS05575	COG0631	protein serine/threonine phosphatase activity
XAC_RS05590	COG0859	PFAM glycosyl transferase family 9
XAC_RS05595	COG3642	lipopolysaccharide core region biosynthetic process
XAC_RS05600	COG1234	tRNA 3'-trailer cleavage
XAC_RS05605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XAC_RS05615	COG0315	cyclic pyranopterin monophosphate synthase activity
XAC_RS05620	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XAC_RS05625	COG0314	molybdopterin synthase activity
XAC_RS05680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XAC_RS05685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XAC_RS05690	COG0537	adenosine 5'-monophosphoramidase activity
XAC_RS05710	COG0714	Associated with various cellular activities
XAC_RS05730	COG0424	maF-like protein
XAC_RS05735	COG1399	metal-binding, possibly nucleic acid-binding protein
XAC_RS05740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XAC_RS05745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAC_RS05760	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS05775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XAC_RS05780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XAC_RS05805	COG3829	transcription factor binding
XAC_RS05825	COG3609	addiction module antidote protein, CC2985 family
XAC_RS05845	COG2373	Large extracellular alpha-helical protein
XAC_RS05860	COG4953	penicillin-binding protein 1C
XAC_RS05870	COG0678	peroxiredoxin activity
XAC_RS05890	COG0330	HflC and HflK could
XAC_RS05895	COG0330	HflC and HflK could
XAC_RS05905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XAC_RS05910	COG0308	aminopeptidase N
XAC_RS05920	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS05925	COG1309	transcriptional regulator
XAC_RS05995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XAC_RS06005	COG3387	PFAM Glycoside hydrolase 15-related
XAC_RS06010	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS06015	COG3537	Alpha-1,2-mannosidase
XAC_RS06035	COG0492	ferredoxin-NADP+ reductase activity
XAC_RS06060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XAC_RS06065	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XAC_RS06070	COG2080	2 iron, 2 sulfur cluster binding
XAC_RS06105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XAC_RS06120	COG0587	DNA-directed DNA polymerase activity
XAC_RS06135	COG1297	OPT oligopeptide transporter protein
XAC_RS06150	COG1506	peptidase
XAC_RS06150	COG0823	Involved in the tonB-independent uptake of proteins
XAC_RS06165	COG2207	Transcriptional regulator
XAC_RS06165	COG1917	Cupin 2, conserved barrel domain protein
XAC_RS06180	COG0753	catalase activity
XAC_RS06185	COG0656	L-ascorbic acid biosynthetic process
XAC_RS06195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XAC_RS06195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XAC_RS06200	COG2814	Major facilitator Superfamily
XAC_RS06215	COG2194	sulfuric ester hydrolase activity
XAC_RS06230	COG0745	RESPONSE REGULATOR receiver
XAC_RS06235	COG0642	Histidine kinase
XAC_RS06245	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XAC_RS06250	COG2894	cell division
XAC_RS06255	COG0850	regulation of cytokinetic process
XAC_RS06270	COG4585	Histidine kinase
XAC_RS06275	COG2197	response regulator
XAC_RS06290	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XAC_RS06315	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XAC_RS06325	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XAC_RS06345	COG1946	Acyl-CoA thioesterase
XAC_RS06360	COG0824	Thioesterase
XAC_RS06365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XAC_RS06370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XAC_RS06375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XAC_RS06380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XAC_RS06385	COG0268	Binds directly to 16S ribosomal RNA
XAC_RS06395	COG0196	riboflavin kinase activity
XAC_RS06400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XAC_RS06405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XAC_RS06410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XAC_RS06425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XAC_RS06430	COG1845	cytochrome c oxidase, subunit III
XAC_RS06435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XAC_RS06450	COG3152	Membrane
XAC_RS06460	COG2207	Transcriptional regulator
XAC_RS06465	COG0326	Molecular chaperone. Has ATPase activity
XAC_RS06475	COG1366	Belongs to the anti-sigma-factor antagonist family
XAC_RS06480	COG1366	Belongs to the anti-sigma-factor antagonist family
XAC_RS06485	COG2172	sigma factor antagonist activity
XAC_RS06510	COG4771	TonB-dependent receptor
XAC_RS06520	COG5507	3-demethylubiquinone-9 3-methyltransferase
XAC_RS06525	COG2205	protein histidine kinase activity
XAC_RS06535	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XAC_RS06540	COG3437	response regulator, receiver
XAC_RS06540	COG4999	Histidine kinase
XAC_RS06540	COG3850	Histidine kinase
XAC_RS06540	COG2205	protein histidine kinase activity
XAC_RS06545	COG0784	Response regulator, receiver
XAC_RS06545	COG4191	Histidine kinase
XAC_RS06575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XAC_RS06580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XAC_RS06595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XAC_RS06600	COG0228	four-way junction DNA binding
XAC_RS06605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XAC_RS06610	COG0336	Belongs to the RNA methyltransferase TrmD family
XAC_RS06615	COG0335	large ribosomal subunit rRNA binding
XAC_RS06645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XAC_RS06655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XAC_RS06665	COG3209	COG3209 Rhs family protein
XAC_RS06685	COG3250	beta-galactosidase activity
XAC_RS06690	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XAC_RS06710	COG1960	acyl-CoA dehydrogenase activity
XAC_RS06715	COG1024	Enoyl-CoA hydratase
XAC_RS06735	COG1250	3-hydroxyacyl-CoA dehydrogenase
XAC_RS06735	COG1024	Enoyl-CoA hydratase
XAC_RS06750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XAC_RS06755	COG0481	GTPase activity
XAC_RS06770	COG0571	ribonuclease III activity
XAC_RS06775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XAC_RS06780	COG1381	Involved in DNA repair and RecF pathway recombination
XAC_RS06790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XAC_RS06795	COG2954	triphosphatase activity
XAC_RS06800	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XAC_RS06805	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
XAC_RS06810	COG3046	protein related to deoxyribodipyrimidine photolyase
XAC_RS06815	COG1472	Belongs to the glycosyl hydrolase 3 family
XAC_RS06820	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XAC_RS06825	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XAC_RS06830	COG1278	Cold shock
XAC_RS06835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAC_RS06845	COG1201	RNA secondary structure unwinding
XAC_RS06850	COG1793	dna ligase
XAC_RS06860	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XAC_RS06860	COG1793	dna ligase
XAC_RS06890	COG0183	Belongs to the thiolase family
XAC_RS06910	COG1451	nucleotide metabolic process
XAC_RS06915	COG5487	UPF0391 membrane protein
XAC_RS06925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XAC_RS06945	COG1077	Cell shape determining protein MreB Mrl
XAC_RS06950	COG1047	Peptidyl-prolyl cis-trans
XAC_RS06960	COG2824	Alkylphosphonate utilization operon protein PhnA
XAC_RS06965	COG1902	pentaerythritol trinitrate reductase activity
XAC_RS06970	COG2814	Major facilitator Superfamily
XAC_RS07005	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XAC_RS07005	COG0392	lysyltransferase activity
XAC_RS07015	COG0251	oxidation-reduction process
XAC_RS07020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XAC_RS07035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XAC_RS07060	COG1595	DNA-templated transcription, initiation
XAC_RS07080	COG2878	Part of a membrane complex involved in electron transport
XAC_RS07090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAC_RS07090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAC_RS07105	COG1131	(ABC) transporter
XAC_RS07110	COG0346	lactoylglutathione lyase activity
XAC_RS07115	COG0833	amino acid
XAC_RS07120	COG2040	homocysteine
XAC_RS07130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XAC_RS07150	COG1695	Transcriptional regulator
XAC_RS07170	COG1981	membrane
XAC_RS07185	COG0825	malonyl-CoA metabolic process
XAC_RS07195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XAC_RS07200	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAC_RS07205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAC_RS07210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAC_RS07215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAC_RS07230	COG0750	zinc metalloprotease
XAC_RS07235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XAC_RS07240	COG0575	Belongs to the CDS family
XAC_RS07245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XAC_RS07250	COG0233	cytoplasmic translational termination
XAC_RS07255	COG0528	UMP kinase activity
XAC_RS07265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XAC_RS07270	COG0052	Belongs to the universal ribosomal protein uS2 family
XAC_RS07310	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XAC_RS07320	COG1393	Belongs to the ArsC family
XAC_RS07325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAC_RS07330	COG0367	asparagine synthase
XAC_RS07340	COG4774	siderophore transport
XAC_RS07360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XAC_RS07390	COG1566	PFAM secretion protein HlyD family protein
XAC_RS07395	COG2814	Major facilitator Superfamily
XAC_RS07445	COG0339	signal peptide processing
XAC_RS07450	COG0386	Belongs to the glutathione peroxidase family
XAC_RS07505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XAC_RS07510	COG0084	hydrolase, TatD family'
XAC_RS07525	COG1960	acyl-CoA dehydrogenase activity
XAC_RS07545	COG0367	asparagine synthase
XAC_RS07555	COG0305	Participates in initiation and elongation during chromosome replication
XAC_RS07560	COG0415	Belongs to the DNA photolyase family
XAC_RS07570	COG0583	DNA-binding transcription factor activity
XAC_RS07615	COG3706	GGDEF domain
XAC_RS07705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XAC_RS07720	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAC_RS07730	COG0497	DNA recombination
XAC_RS07735	COG1420	regulation of RNA biosynthetic process
XAC_RS07740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XAC_RS07745	COG0443	Heat shock 70 kDa protein
XAC_RS07750	COG0484	heat shock protein binding
XAC_RS07755	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XAC_RS07785	COG0583	DNA-binding transcription factor activity
XAC_RS07790	COG1132	(ABC) transporter
XAC_RS07825	COG2850	peptidyl-arginine hydroxylation
XAC_RS07845	COG1253	flavin adenine dinucleotide binding
XAC_RS07875	COG1131	(ABC) transporter
XAC_RS07880	COG1725	Transcriptional regulator
XAC_RS07885	COG0386	Belongs to the glutathione peroxidase family
XAC_RS07900	COG2900	Belongs to the SlyX family
XAC_RS07925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAC_RS07935	COG0646	methionine synthase
XAC_RS07935	COG1410	methionine synthase
XAC_RS07940	COG0646	methionine synthase
XAC_RS07940	COG1410	methionine synthase
XAC_RS07945	COG2226	methyltransferase
XAC_RS07950	COG1960	acyl-CoA dehydrogenase activity
XAC_RS07965	COG0557	exoribonuclease II activity
XAC_RS07975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XAC_RS07985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XAC_RS07995	COG0704	Plays a role in the regulation of phosphate uptake
XAC_RS08000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XAC_RS08005	COG0581	inorganic phosphate transmembrane transporter activity
XAC_RS08010	COG0573	inorganic phosphate transmembrane transporter activity
XAC_RS08015	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XAC_RS08040	COG0659	secondary active sulfate transmembrane transporter activity
XAC_RS08045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XAC_RS08055	COG1024	Enoyl-CoA hydratase
XAC_RS08065	COG0494	nUDIX hydrolase
XAC_RS08100	COG0488	(ABC) transporter
XAC_RS08105	COG0116	Belongs to the methyltransferase superfamily
XAC_RS08105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XAC_RS08110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XAC_RS08135	COG2925	Exonuclease
XAC_RS08140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAC_RS08145	COG3844	kynureninase activity
XAC_RS08155	COG0662	Cupin 2, conserved barrel domain protein
XAC_RS08160	COG0288	reversible hydration of carbon dioxide
XAC_RS08220	COG2808	Putative FMN-binding domain
XAC_RS08240	COG0017	Asparaginyl-tRNA synthetase
XAC_RS08245	COG0316	Belongs to the HesB IscA family
XAC_RS08250	COG0360	Binds together with S18 to 16S ribosomal RNA
XAC_RS08255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XAC_RS08260	COG0359	binds to the 23S rRNA
XAC_RS08270	COG3115	cell septum assembly
XAC_RS08280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAC_RS08285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XAC_RS08290	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XAC_RS08300	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XAC_RS08320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XAC_RS08330	COG2986	histidine ammonia-lyase
XAC_RS08335	COG1228	amidohydrolase
XAC_RS08380	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XAC_RS08385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XAC_RS08390	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XAC_RS08395	COG1605	Chorismate mutase
XAC_RS08395	COG0077	Prephenate dehydratase
XAC_RS08400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XAC_RS08415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XAC_RS08420	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XAC_RS08425	COG0583	DNA-binding transcription factor activity
XAC_RS08460	COG2801	Transposase and inactivated derivatives
XAC_RS08480	COG0840	transmembrane signaling receptor activity
XAC_RS08515	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XAC_RS08520	COG4191	Histidine kinase
XAC_RS08520	COG0784	Response regulator, receiver
XAC_RS08535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAC_RS08545	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XAC_RS08555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XAC_RS08570	COG1595	DNA-templated transcription, initiation
XAC_RS08625	COG2244	polysaccharide biosynthetic process
XAC_RS08655	COG2264	protein methyltransferase activity
XAC_RS08665	COG0438	transferase activity, transferring glycosyl groups
XAC_RS08680	COG1136	(ABC) transporter
XAC_RS08690	COG0477	Major facilitator Superfamily
XAC_RS08695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XAC_RS08710	COG1253	flavin adenine dinucleotide binding
XAC_RS08720	COG0306	phosphate transporter
XAC_RS08745	COG0504	CTP synthase activity
XAC_RS08750	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XAC_RS08760	COG0148	phosphopyruvate hydratase activity
XAC_RS08765	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XAC_RS08770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XAC_RS08775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XAC_RS08780	COG0585	pseudouridine synthase activity
XAC_RS08785	COG2840	Smr protein MutS2
XAC_RS08790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XAC_RS08795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XAC_RS08800	COG1238	metal cluster binding
XAC_RS08815	COG1534	Rna-binding protein
XAC_RS08820	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XAC_RS08830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XAC_RS08835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XAC_RS08845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XAC_RS08850	COG1546	Belongs to the CinA family
XAC_RS08860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XAC_RS08865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XAC_RS08870	COG2137	regulation of response to DNA damage stimulus
XAC_RS08875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XAC_RS08880	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XAC_RS08895	COG1741	Belongs to the pirin family
XAC_RS08905	COG0583	DNA-binding transcription factor activity
XAC_RS08930	COG0352	thiamine-phosphate diphosphorylase activity
XAC_RS08930	COG0351	phosphomethylpyrimidine kinase
XAC_RS08945	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XAC_RS08950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XAC_RS08965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XAC_RS08975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XAC_RS08980	COG3734	2-keto-3-deoxy-galactonokinase
XAC_RS08990	COG4948	Mandelate Racemase Muconate Lactonizing
XAC_RS08995	COG0800	Aldolase
XAC_RS09035	COG1501	Belongs to the glycosyl hydrolase 31 family
XAC_RS09045	COG1070	Carbohydrate kinase
XAC_RS09050	COG2115	Belongs to the xylose isomerase family
XAC_RS09055	COG0477	Major facilitator Superfamily
XAC_RS09065	COG0860	N-Acetylmuramoyl-L-alanine amidase
XAC_RS09070	COG1469	GTP cyclohydrolase I activity
XAC_RS09090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XAC_RS09095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XAC_RS09100	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XAC_RS09105	COG0166	Belongs to the GPI family
XAC_RS09125	COG1472	Belongs to the glycosyl hydrolase 3 family
XAC_RS09135	COG2203	Gaf domain
XAC_RS09135	COG3706	GGDEF domain
XAC_RS09135	COG4251	negative regulation of phosphorylation
XAC_RS09135	COG5001	Diguanylate cyclase
XAC_RS09140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC_RS09145	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XAC_RS09155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XAC_RS09160	COG0671	phosphoesterase, PA-phosphatase related
XAC_RS09170	COG1794	racemase activity, acting on amino acids and derivatives
XAC_RS09175	COG0697	spore germination
XAC_RS09180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XAC_RS09185	COG0167	dihydroorotate dehydrogenase activity
XAC_RS09200	COG1012	belongs to the aldehyde dehydrogenase family
XAC_RS09215	COG1215	transferase activity, transferring glycosyl groups
XAC_RS09220	COG0726	polysaccharide deacetylase
XAC_RS09220	COG1649	PFAM Uncharacterised BCR, COG1649
XAC_RS09235	COG3210	domain, Protein
XAC_RS09240	COG3210	domain, Protein
XAC_RS09280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAC_RS09285	COG0124	histidyl-tRNA synthetase
XAC_RS09295	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XAC_RS09300	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XAC_RS09305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAC_RS09310	COG0131	Imidazoleglycerol-phosphate dehydratase
XAC_RS09310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XAC_RS09315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XAC_RS09320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XAC_RS09325	COG0107	imidazoleglycerol-phosphate synthase activity
XAC_RS09330	COG0140	phosphoribosyl-ATP diphosphatase activity
XAC_RS09330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XAC_RS09345	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XAC_RS09350	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XAC_RS09355	COG0235	Class ii aldolase
XAC_RS09360	COG0531	amino acid
XAC_RS09365	COG0531	amino acid
XAC_RS09375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XAC_RS09380	COG0277	FAD linked oxidase domain protein
XAC_RS09400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XAC_RS09445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XAC_RS09450	COG2258	MOSC domain
XAC_RS09455	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XAC_RS09460	COG0505	Belongs to the CarA family
XAC_RS09470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XAC_RS09475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAC_RS09485	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XAC_RS09530	COG3279	Response regulator of the LytR AlgR family
XAC_RS09535	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XAC_RS09540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XAC_RS09550	COG2205	protein histidine kinase activity
XAC_RS09550	COG2198	Histidine kinase
XAC_RS09550	COG0784	Response regulator, receiver
XAC_RS09555	COG1024	Enoyl-CoA hydratase
XAC_RS09560	COG0318	PFAM AMP-dependent synthetase and ligase
XAC_RS09595	COG2267	carboxylic ester hydrolase activity
XAC_RS09605	COG2201	protein-glutamate methylesterase activity
XAC_RS09610	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XAC_RS09620	COG0840	transmembrane signaling receptor activity
XAC_RS09625	COG0840	transmembrane signaling receptor activity
XAC_RS09630	COG0840	transmembrane signaling receptor activity
XAC_RS09640	COG0840	transmembrane signaling receptor activity
XAC_RS09645	COG0840	transmembrane signaling receptor activity
XAC_RS09650	COG0840	transmembrane signaling receptor activity
XAC_RS09655	COG0840	transmembrane signaling receptor activity
XAC_RS09670	COG0840	transmembrane signaling receptor activity
XAC_RS09690	COG0840	transmembrane signaling receptor activity
XAC_RS09695	COG2198	Histidine kinase
XAC_RS09695	COG0643	Histidine kinase
XAC_RS09700	COG0745	RESPONSE REGULATOR receiver
XAC_RS09710	COG0835	chemotaxis
XAC_RS09720	COG1360	Flagellar Motor Protein
XAC_RS09725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XAC_RS09810	COG0641	radical SAM
XAC_RS09825	COG2198	Histidine kinase
XAC_RS09825	COG0643	Histidine kinase
XAC_RS09825	COG0784	Response regulator, receiver
XAC_RS09855	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XAC_RS09885	COG1684	flagellar biosynthetic protein fliR
XAC_RS09900	COG3190	flagellar
XAC_RS09950	COG1677	Flagellar hook-basal body complex protein FliE
XAC_RS09980	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS09985	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS09990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAC_RS10010	COG2201	protein-glutamate methylesterase activity
XAC_RS10040	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XAC_RS10045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XAC_RS10050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XAC_RS10060	COG1705	Flagellar rod assembly protein muramidase FlgJ
XAC_RS10060	COG3951	Flagellar rod assembly protein muramidase FlgJ
XAC_RS10065	COG1706	bacterial-type flagellum-dependent cell motility
XAC_RS10070	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XAC_RS10080	COG4787	bacterial-type flagellum-dependent cell motility
XAC_RS10090	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XAC_RS10095	COG1558	bacterial-type flagellum-dependent cell motility
XAC_RS10105	COG0784	Response regulator, receiver
XAC_RS10105	COG0835	chemotaxis
XAC_RS10125	COG5002	protein histidine kinase activity
XAC_RS10155	COG2915	High frequency lysogenization protein hflD homolog
XAC_RS10160	COG0482	sulfurtransferase activity
XAC_RS10175	COG0542	response to heat
XAC_RS10185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XAC_RS10195	COG0492	ferredoxin-NADP+ reductase activity
XAC_RS10200	COG1674	ftsk spoiiie
XAC_RS10210	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XAC_RS10220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XAC_RS10225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XAC_RS10235	COG0183	Belongs to the thiolase family
XAC_RS10240	COG1250	3-hydroxyacyl-CoA dehydrogenase
XAC_RS10240	COG1024	Enoyl-CoA hydratase
XAC_RS10255	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XAC_RS10265	COG1426	Protein conserved in bacteria
XAC_RS10275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAC_RS10280	COG1160	GTP binding
XAC_RS10285	COG0303	'Molybdopterin
XAC_RS10290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XAC_RS10325	COG0708	Exodeoxyribonuclease III
XAC_RS10335	COG0303	'Molybdopterin
XAC_RS10340	COG0746	molybdenum cofactor guanylyltransferase activity
XAC_RS10355	COG1914	H( )-stimulated, divalent metal cation uptake system
XAC_RS10370	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XAC_RS10375	COG0668	transmembrane transport
XAC_RS10385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XAC_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS10405	COG1183	phosphatidylcholine synthase activity
XAC_RS10415	COG3243	poly(R)-hydroxyalkanoic acid synthase
XAC_RS10430	COG0723	plastoquinol--plastocyanin reductase activity
XAC_RS10430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC_RS10440	COG2183	response to ionizing radiation
XAC_RS10445	COG0784	Response regulator, receiver
XAC_RS10445	COG2205	protein histidine kinase activity
XAC_RS10510	COG0800	Aldolase
XAC_RS10515	COG0129	dihydroxy-acid dehydratase activity
XAC_RS10520	COG0363	glucosamine-6-phosphate deaminase activity
XAC_RS10525	COG0837	glucose binding
XAC_RS10530	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XAC_RS10550	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XAC_RS10565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XAC_RS10570	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XAC_RS10580	COG4591	ABC-type transport system involved in lipoprotein release permease component
XAC_RS10585	COG1136	(ABC) transporter
XAC_RS10600	COG0811	peptide transport
XAC_RS10610	COG1132	(ABC) transporter
XAC_RS10615	COG1663	tetraacyldisaccharide 4'-kinase activity
XAC_RS10620	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XAC_RS10625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XAC_RS10635	COG0322	excinuclease ABC activity
XAC_RS10640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XAC_RS10660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XAC_RS10665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XAC_RS10680	COG2801	Transposase and inactivated derivatives
XAC_RS10695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XAC_RS10715	COG1054	Belongs to the UPF0176 family
XAC_RS10725	COG1530	ribonuclease E activity
XAC_RS10735	COG3064	Membrane
XAC_RS10740	COG0428	transporter
XAC_RS10750	COG2154	pterin-4-alpha-carbinolamine dehydratase
XAC_RS10755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XAC_RS10755	COG0316	Belongs to the HesB IscA family
XAC_RS10810	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS10845	COG1238	metal cluster binding
XAC_RS10880	COG3279	Response regulator of the LytR AlgR family
XAC_RS10925	COG4566	intracellular signal transduction
XAC_RS10935	COG5001	Diguanylate cyclase
XAC_RS10950	COG3685	Protein conserved in bacteria
XAC_RS10970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XAC_RS10970	COG1648	precorrin-2 dehydrogenase activity
XAC_RS10985	COG2814	Major facilitator Superfamily
XAC_RS11000	COG1335	isochorismatase
XAC_RS11015	COG2197	response regulator
XAC_RS11035	COG0583	DNA-binding transcription factor activity
XAC_RS11040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XAC_RS11045	COG3002	Belongs to the UPF0753 family
XAC_RS11060	COG1396	sequence-specific DNA binding
XAC_RS11065	COG5489	Protein of unknown function (DUF736)
XAC_RS11070	COG2003	Belongs to the UPF0758 family
XAC_RS11095	COG0582	viral genome integration into host DNA
XAC_RS11110	COG4774	siderophore transport
XAC_RS11125	COG2336	PFAM SpoVT AbrB
XAC_RS11150	COG4206	TonB-dependent receptor
XAC_RS11170	COG2273	Hydrolase Family 16
XAC_RS11170	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XAC_RS11190	COG2274	protein secretion by the type I secretion system
XAC_RS11240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XAC_RS11245	COG0270	DNA (cytosine-5-)-methyltransferase activity
XAC_RS11295	COG4804	nuclease activity
XAC_RS11315	COG5006	permease, DMT superfamily
XAC_RS11330	COG2249	NAD(P)H dehydrogenase (quinone) activity
XAC_RS11340	COG3938	Belongs to the proline racemase family
XAC_RS11355	COG2807	transmembrane transport
XAC_RS11360	COG2207	Transcriptional regulator
XAC_RS11510	COG0210	DNA helicase
XAC_RS11590	COG2084	Dehydrogenase
XAC_RS11610	COG2003	Belongs to the UPF0758 family
XAC_RS11645	COG0582	viral genome integration into host DNA
XAC_RS11650	COG0519	Catalyzes the synthesis of GMP from XMP
XAC_RS11650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XAC_RS11660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XAC_RS11670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XAC_RS11670	COG0475	glutathione-regulated potassium exporter activity
XAC_RS11675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XAC_RS11685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XAC_RS11690	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XAC_RS11700	COG0776	regulation of translation
XAC_RS11705	COG0539	negative regulation of cytoplasmic translation
XAC_RS11710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XAC_RS11725	COG2957	Belongs to the agmatine deiminase family
XAC_RS11730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XAC_RS11755	COG0395	ABC-type sugar transport system, permease component
XAC_RS11760	COG1175	transmembrane transport
XAC_RS11790	COG2350	Protein conserved in bacteria
XAC_RS11795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XAC_RS11800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XAC_RS11805	COG1187	pseudouridine synthase activity
XAC_RS11825	COG0436	Aminotransferase
XAC_RS11830	COG4133	protoheme IX ABC transporter activity
XAC_RS11850	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XAC_RS11855	COG1138	Cytochrome C-type biogenesis protein
XAC_RS11875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAC_RS11880	COG1278	Cold shock
XAC_RS11885	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XAC_RS11890	COG4988	ABC transporter
XAC_RS11900	COG1294	oxidase, subunit
XAC_RS11925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XAC_RS11930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XAC_RS11940	COG0165	Argininosuccinate lyase
XAC_RS11945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XAC_RS11955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XAC_RS11960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAC_RS11970	COG0137	argininosuccinate synthase activity
XAC_RS11975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XAC_RS11985	COG0215	cysteine-tRNA ligase activity
XAC_RS11990	COG2166	iron-sulfur cluster assembly
XAC_RS12010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XAC_RS12015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XAC_RS12040	COG4302	ethanolamine ammonia-lyase activity
XAC_RS12070	COG2963	transposase activity
XAC_RS12090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XAC_RS12095	COG0402	S-adenosylhomocysteine deaminase activity
XAC_RS12105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XAC_RS12110	COG1509	lysine 2,3-aminomutase activity
XAC_RS12115	COG5001	Diguanylate cyclase
XAC_RS12115	COG3300	MHYT domain
XAC_RS12130	COG0483	inositol monophosphate 1-phosphatase activity
XAC_RS12135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XAC_RS12150	COG0488	(ABC) transporter
XAC_RS12155	COG0513	Belongs to the DEAD box helicase family
XAC_RS12160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XAC_RS12165	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XAC_RS12175	COG0625	glutathione transferase activity
XAC_RS12185	COG4681	YaeQ
XAC_RS12190	COG2081	HI0933 family
XAC_RS12200	COG0501	Belongs to the peptidase M48B family
XAC_RS12205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAC_RS12210	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS12230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XAC_RS12235	COG0860	N-Acetylmuramoyl-L-alanine amidase
XAC_RS12240	COG0802	atpase or kinase
XAC_RS12245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XAC_RS12245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XAC_RS12250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XAC_RS12255	COG1570	exodeoxyribonuclease VII activity
XAC_RS12265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XAC_RS12445	COG0835	chemotaxis
XAC_RS12450	COG0840	transmembrane signaling receptor activity
XAC_RS12455	COG2094	Belongs to the DNA glycosylase MPG family
XAC_RS12460	COG1201	RNA secondary structure unwinding
XAC_RS12475	COG2969	positive regulation of protein catabolic process
XAC_RS12480	COG0625	glutathione transferase activity
XAC_RS12485	COG2857	Cytochrome c1
XAC_RS12490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XAC_RS12495	COG0723	plastoquinol--plastocyanin reductase activity
XAC_RS12500	COG0741	lytic transglycosylase activity
XAC_RS12515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XAC_RS12520	COG1702	phosphate starvation-inducible protein PhoH
XAC_RS12530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XAC_RS12540	COG4535	Mg2 and Co2 transporter CorC
XAC_RS12555	COG1012	belongs to the aldehyde dehydrogenase family
XAC_RS12565	COG1177	transmembrane transport
XAC_RS12570	COG1176	ABC-type spermidine putrescine transport system, permease component I
XAC_RS12575	COG3842	ATPase activity
XAC_RS12595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XAC_RS12610	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XAC_RS12615	COG0174	glutamine synthetase
XAC_RS12620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC_RS12630	COG2703	oxygen carrier activity
XAC_RS12635	COG0477	Major facilitator Superfamily
XAC_RS12645	COG0243	molybdopterin cofactor binding
XAC_RS12650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XAC_RS12655	COG2223	nitrite transmembrane transporter activity
XAC_RS12660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XAC_RS12670	COG2733	membrane
XAC_RS12675	COG2205	protein histidine kinase activity
XAC_RS12675	COG5002	protein histidine kinase activity
XAC_RS12675	COG0784	Response regulator, receiver
XAC_RS12685	COG0477	Major facilitator Superfamily
XAC_RS12690	COG2902	Dehydrogenase
XAC_RS12700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC_RS12705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAC_RS12710	COG1609	Transcriptional regulator
XAC_RS12715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XAC_RS12715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAC_RS12720	COG1105	Belongs to the carbohydrate kinase PfkB family
XAC_RS12725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XAC_RS12725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XAC_RS12770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XAC_RS12780	COG1862	Preprotein translocase
XAC_RS12785	COG0343	queuine tRNA-ribosyltransferase activity
XAC_RS12790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XAC_RS12830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XAC_RS12835	COG3291	Pkd domain containing protein
XAC_RS12845	COG0405	Gamma-glutamyltransferase
XAC_RS12850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XAC_RS12865	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XAC_RS12870	COG0742	ribosomal rna small subunit methyltransferase
XAC_RS12875	COG0326	Molecular chaperone. Has ATPase activity
XAC_RS12945	COG0531	amino acid
XAC_RS12960	COG0006	proline dipeptidase activity
XAC_RS12970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XAC_RS12985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC_RS12990	COG3938	Belongs to the proline racemase family
XAC_RS13000	COG0552	protein localization to endoplasmic reticulum
XAC_RS13005	COG1194	a g-specific adenine glycosylase
XAC_RS13010	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XAC_RS13015	COG4191	Histidine kinase
XAC_RS13015	COG0784	Response regulator, receiver
XAC_RS13030	COG0322	excinuclease ABC activity
XAC_RS13045	COG3040	lipid binding
XAC_RS13055	COG1960	acyl-CoA dehydrogenase activity
XAC_RS13065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XAC_RS13085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAC_RS13090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAC_RS13095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAC_RS13120	COG0438	transferase activity, transferring glycosyl groups
XAC_RS13130	COG0438	transferase activity, transferring glycosyl groups
XAC_RS13135	COG0438	transferase activity, transferring glycosyl groups
XAC_RS13185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAC_RS13185	COG0072	phenylalanine-tRNA ligase activity
XAC_RS13190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XAC_RS13205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XAC_RS13210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XAC_RS13235	COG1082	Xylose isomerase domain protein TIM barrel
XAC_RS13250	COG0366	Alpha amylase catalytic
XAC_RS13255	COG2963	transposase activity
XAC_RS13325	COG2948	multi-organism process
XAC_RS13345	COG3505	Type IV secretory pathway VirD4
XAC_RS13360	COG0556	nucleotide-excision repair
XAC_RS13430	COG4695	Portal protein
XAC_RS13475	COG3179	chitinase
XAC_RS13555	COG3275	phosphorelay sensor kinase activity
XAC_RS13560	COG1611	Belongs to the LOG family
XAC_RS13570	COG2095	MarC family integral membrane protein
XAC_RS13580	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XAC_RS13615	COG1185	polyribonucleotide nucleotidyltransferase activity
XAC_RS13620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XAC_RS13625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XAC_RS13630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XAC_RS13635	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XAC_RS13640	COG0195	Participates in both transcription termination and antitermination
XAC_RS13645	COG0779	Required for maturation of 30S ribosomal subunits
XAC_RS13655	COG1007	ATP synthesis coupled electron transport
XAC_RS13680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC_RS13685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XAC_RS13695	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XAC_RS13700	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XAC_RS13705	COG0649	NAD binding
XAC_RS13710	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC_RS13715	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC_RS13720	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC_RS13735	COG0149	triose-phosphate isomerase activity
XAC_RS13740	COG0300	oxidoreductase activity
XAC_RS13775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XAC_RS13780	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XAC_RS13785	COG0159	tryptophan synthase activity
XAC_RS13795	COG0133	tryptophan synthase activity
XAC_RS13805	COG0135	phosphoribosylanthranilate isomerase activity
XAC_RS13810	COG0101	tRNA pseudouridine synthase activity
XAC_RS13830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XAC_RS13835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XAC_RS13840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XAC_RS13845	COG2890	protein-(glutamine-N5) methyltransferase activity
XAC_RS13855	COG0688	phosphatidylethanolamine metabolic process
XAC_RS13865	COG0433	COG0433 Predicted ATPase
XAC_RS13870	COG0494	nUDIX hydrolase
XAC_RS13885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAC_RS13890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XAC_RS13915	COG0717	Belongs to the dCTP deaminase family
XAC_RS13920	COG0489	protein tyrosine kinase activity
XAC_RS13940	COG3590	peptidase
XAC_RS13945	COG3590	peptidase
XAC_RS13965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XAC_RS13970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC_RS13975	COG2311	Membrane
XAC_RS13980	COG1047	Peptidyl-prolyl cis-trans
XAC_RS13985	COG0791	NLP P60 protein
XAC_RS13990	COG0791	NLP P60 protein
XAC_RS14000	COG4106	trans-aconitate 2-methyltransferase activity
XAC_RS14005	COG1301	dicarboxylic acid transport
XAC_RS14010	COG1785	Belongs to the alkaline phosphatase family
XAC_RS14015	COG0037	tRNA processing
XAC_RS14020	COG1722	exodeoxyribonuclease VII activity
XAC_RS14025	COG0142	geranyltranstransferase activity
XAC_RS14030	COG4104	PAAR repeat-containing protein
XAC_RS14040	COG0312	modulator of DNA gyrase
XAC_RS14045	COG3028	Belongs to the UPF0307 family
XAC_RS14050	COG0312	modulator of DNA gyrase
XAC_RS14060	COG3164	Protein of unknown function
XAC_RS14070	COG0424	maF-like protein
XAC_RS14075	COG2968	Membrane
XAC_RS14090	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XAC_RS14105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XAC_RS14120	COG0495	leucyl-tRNA aminoacylation
XAC_RS14130	COG3118	belongs to the thioredoxin family
XAC_RS14155	COG2155	Conserved Protein
XAC_RS14200	COG1132	(ABC) transporter
XAC_RS14225	COG1538	Outer membrane efflux protein
XAC_RS14230	COG0745	RESPONSE REGULATOR receiver
XAC_RS14235	COG5002	protein histidine kinase activity
XAC_RS14235	COG5000	phosphorelay sensor kinase activity
XAC_RS14240	COG0475	glutathione-regulated potassium exporter activity
XAC_RS14250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XAC_RS14275	COG1187	pseudouridine synthase activity
XAC_RS14280	COG5002	protein histidine kinase activity
XAC_RS14280	COG5001	Diguanylate cyclase
XAC_RS14330	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XAC_RS14395	COG0667	Aldo Keto reductase
XAC_RS14400	COG2814	Major facilitator Superfamily
XAC_RS14405	COG0583	DNA-binding transcription factor activity
XAC_RS14415	COG2207	Transcriptional regulator
XAC_RS14425	COG1309	transcriptional regulator
XAC_RS14450	COG0735	belongs to the Fur family
XAC_RS14455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAC_RS14480	COG4452	Inner membrane protein CreD
XAC_RS14490	COG2205	protein histidine kinase activity
XAC_RS14495	COG0745	RESPONSE REGULATOR receiver
XAC_RS14500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XAC_RS14510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XAC_RS14545	COG0643	Histidine kinase
XAC_RS14545	COG2198	Histidine kinase
XAC_RS14550	COG0840	transmembrane signaling receptor activity
XAC_RS14555	COG0835	chemotaxis
XAC_RS14560	COG2202	Pas domain
XAC_RS14560	COG2200	EAL domain
XAC_RS14560	COG2199	diguanylate cyclase activity
XAC_RS14565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XAC_RS14570	COG2201	protein-glutamate methylesterase activity
XAC_RS14575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC_RS14580	COG3590	peptidase
XAC_RS14590	COG0588	phosphoglycerate mutase activity
XAC_RS14595	COG1515	deoxyribonuclease V activity
XAC_RS14605	COG1741	Belongs to the pirin family
XAC_RS14620	COG1741	Belongs to the pirin family
XAC_RS14625	COG1966	Carbon starvation protein
XAC_RS14630	COG2879	small protein
XAC_RS14685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XAC_RS14690	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XAC_RS14695	COG2080	2 iron, 2 sulfur cluster binding
XAC_RS14705	COG2203	Gaf domain
XAC_RS14705	COG4251	negative regulation of phosphorylation
XAC_RS14705	COG5001	Diguanylate cyclase
XAC_RS14705	COG3706	GGDEF domain
XAC_RS14745	COG0629	single-stranded DNA binding
XAC_RS14750	COG0142	geranyltranstransferase activity
XAC_RS14760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XAC_RS14775	COG0527	aspartate kinase activity
XAC_RS14780	COG0384	phenazine biosynthesis protein PhzF
XAC_RS14785	COG0384	phenazine biosynthesis protein PhzF
XAC_RS14795	COG1764	response to oxidative stress
XAC_RS14800	COG0540	Belongs to the ATCase OTCase family
XAC_RS14805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XAC_RS14810	COG1678	Uncharacterized ACR, COG1678
XAC_RS14820	COG0519	Catalyzes the synthesis of GMP from XMP
XAC_RS14835	COG5297	Belongs to the glycosyl hydrolase family 6
XAC_RS14850	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XAC_RS14865	COG0739	heme binding
XAC_RS14885	COG0693	protein deglycase activity
XAC_RS14895	COG1959	2 iron, 2 sulfur cluster binding
XAC_RS14900	COG0719	Fe-S assembly protein
XAC_RS14905	COG0396	ATPase activity
XAC_RS14910	COG0719	Fe-S assembly protein
XAC_RS14915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XAC_RS14925	COG2146	nitrite reductase [NAD(P)H] activity
XAC_RS14930	COG4774	siderophore transport
XAC_RS14935	COG3128	pkhd-type hydroxylase
XAC_RS14960	COG1477	protein flavinylation
XAC_RS14965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XAC_RS14980	COG1555	photosystem II stabilization
XAC_RS14985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAC_RS14995	COG3178	'Phosphotransferase
XAC_RS15000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XAC_RS15010	COG0628	permease
XAC_RS15020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XAC_RS15030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XAC_RS15050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XAC_RS15055	COG0271	Belongs to the BolA IbaG family
XAC_RS15065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XAC_RS15075	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XAC_RS15080	COG1137	ATPase activity
XAC_RS15095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAC_RS15100	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XAC_RS15105	COG1660	Displays ATPase and GTPase activities
XAC_RS15115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAC_RS15120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XAC_RS15125	COG2239	Acts as a magnesium transporter
XAC_RS15135	COG1294	oxidase, subunit
XAC_RS15140	COG1271	oxidase subunit
XAC_RS15150	COG1113	amino acid transport
XAC_RS15170	COG2197	response regulator
XAC_RS15175	COG0531	amino acid
XAC_RS15195	COG1234	tRNA 3'-trailer cleavage
XAC_RS15230	COG2814	Major facilitator Superfamily
XAC_RS15240	COG0754	glutathionylspermidine amidase activity
XAC_RS15265	COG1842	Phage shock protein A
XAC_RS15275	COG0259	pyridoxamine-phosphate oxidase activity
XAC_RS15280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XAC_RS15285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XAC_RS15295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XAC_RS15370	COG2814	Major facilitator Superfamily
XAC_RS15390	COG2205	protein histidine kinase activity
XAC_RS15390	COG2198	Histidine kinase
XAC_RS15390	COG0784	Response regulator, receiver
XAC_RS15395	COG2353	YceI-like domain
XAC_RS15415	COG1760	l-serine dehydratase
XAC_RS15425	COG0527	aspartate kinase activity
XAC_RS15425	COG0460	homoserine dehydrogenase
XAC_RS15430	COG0626	cystathionine gamma-synthase activity
XAC_RS15435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAC_RS15440	COG0739	heme binding
XAC_RS15445	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XAC_RS15450	COG1272	protein, Hemolysin III
XAC_RS15455	COG2982	Protein involved in outer membrane biogenesis
XAC_RS15460	COG0517	IMP dehydrogenase activity
XAC_RS15460	COG0516	GMP reductase activity
XAC_RS15465	COG0463	Glycosyl transferase, family 2
XAC_RS15470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XAC_RS15475	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XAC_RS15485	COG4771	TonB-dependent receptor
XAC_RS15495	COG1309	transcriptional regulator
XAC_RS15505	COG1960	acyl-CoA dehydrogenase activity
XAC_RS15530	COG0509	glycine decarboxylation via glycine cleavage system
XAC_RS15535	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XAC_RS15545	COG0330	HflC and HflK could
XAC_RS15550	COG1742	UPF0060 membrane protein
XAC_RS15555	COG3956	TIGRFAM MazG family protein
XAC_RS15565	COG0494	nUDIX hydrolase
XAC_RS15575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XAC_RS15580	COG0837	glucose binding
XAC_RS15595	COG3858	chitin binding
XAC_RS15595	COG1388	LysM domain
XAC_RS15600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XAC_RS15610	COG1472	Belongs to the glycosyl hydrolase 3 family
XAC_RS15625	COG0531	amino acid
XAC_RS15635	COG1486	melibiose metabolic process
XAC_RS15645	COG3537	Alpha-1,2-mannosidase
XAC_RS15680	COG3142	Participates in the control of copper homeostasis
XAC_RS15685	COG1446	asparaginase
XAC_RS15715	COG0784	Response regulator, receiver
XAC_RS15715	COG0643	Histidine kinase
XAC_RS15715	COG2198	Histidine kinase
XAC_RS15720	COG0840	transmembrane signaling receptor activity
XAC_RS15725	COG0835	chemotaxis
XAC_RS15740	COG0189	ligase activity
XAC_RS15750	COG1397	ADP-ribosylglycohydrolase
XAC_RS15760	COG1199	ATP-dependent helicase activity
XAC_RS15770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XAC_RS15775	COG1215	transferase activity, transferring glycosyl groups
XAC_RS15785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XAC_RS15790	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XAC_RS15795	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XAC_RS15800	COG0535	radical SAM domain protein
XAC_RS15805	COG0535	radical SAM domain protein
XAC_RS15820	COG0837	glucose binding
XAC_RS15830	COG1643	Atp-dependent helicase
XAC_RS15835	COG0783	Belongs to the Dps family
XAC_RS15840	COG0514	ATP-dependent DNA helicase (RecQ)
XAC_RS15875	COG0840	transmembrane signaling receptor activity
XAC_RS15895	COG3920	Histidine kinase
XAC_RS15900	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XAC_RS15910	COG0602	queuosine metabolic process
XAC_RS15920	COG2885	chlorophyll binding
XAC_RS15925	COG0823	Involved in the tonB-independent uptake of proteins
XAC_RS15935	COG0848	biopolymer transport protein
XAC_RS15945	COG0824	Thioesterase
XAC_RS15950	COG2255	four-way junction helicase activity
XAC_RS15960	COG3158	transport of potassium into the cell
XAC_RS15965	COG0632	four-way junction helicase activity
XAC_RS15970	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XAC_RS15975	COG0217	transcriptional regulatory protein
XAC_RS15990	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XAC_RS16005	COG0477	Major facilitator Superfamily
XAC_RS16040	COG0488	(ABC) transporter
XAC_RS16075	COG4651	solute:proton antiporter activity
XAC_RS16075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XAC_RS16100	COG4772	TonB-dependent receptor
XAC_RS16110	COG4264	IucA IucC family
XAC_RS16125	COG0019	diaminopimelate decarboxylase activity
XAC_RS16150	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XAC_RS16160	COG1492	cobalamin metabolic process
XAC_RS16170	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XAC_RS16190	COG4206	TonB-dependent receptor
XAC_RS16195	COG0542	response to heat
XAC_RS16200	COG1116	anion transmembrane transporter activity
XAC_RS16205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XAC_RS16210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XAC_RS16215	COG0667	Aldo Keto reductase
XAC_RS16220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XAC_RS16225	COG4771	TonB-dependent receptor
XAC_RS16230	COG2827	Endonuclease containing a URI domain
XAC_RS16270	COG1877	trehalose-phosphatase activity
XAC_RS16275	COG3387	PFAM Glycoside hydrolase 15-related
XAC_RS16290	COG0840	transmembrane signaling receptor activity
XAC_RS16295	COG3011	Protein conserved in bacteria
XAC_RS16310	COG0564	pseudouridine synthase activity
XAC_RS16315	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAC_RS16325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XAC_RS16325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XAC_RS16355	COG2951	lytic endotransglycosylase activity
XAC_RS16360	COG4644	lycopene metabolic process
XAC_RS16380	COG2369	cell adhesion
XAC_RS16405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XAC_RS16410	COG0045	succinate-CoA ligase (ADP-forming) activity
XAC_RS16425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XAC_RS16455	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XAC_RS16460	COG0237	dephospho-CoA kinase activity
XAC_RS16480	COG2801	Transposase and inactivated derivatives
XAC_RS16485	COG5002	protein histidine kinase activity
XAC_RS16490	COG0745	RESPONSE REGULATOR receiver
XAC_RS16500	COG0189	ligase activity
XAC_RS16560	COG2003	Belongs to the UPF0758 family
XAC_RS16585	COG4191	Histidine kinase
XAC_RS16585	COG0784	Response regulator, receiver
XAC_RS16590	COG4191	Histidine kinase
XAC_RS16590	COG0784	Response regulator, receiver
XAC_RS16700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XAC_RS16725	COG2022	thiamine diphosphate biosynthetic process
XAC_RS16730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XAC_RS16735	COG3273	potassium ion transport
XAC_RS16735	COG0471	metal ion transport
XAC_RS16755	COG1970	mechanosensitive ion channel activity
XAC_RS16780	COG3250	beta-galactosidase activity
XAC_RS16785	COG4948	Mandelate Racemase Muconate Lactonizing
XAC_RS16800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XAC_RS16810	COG0308	aminopeptidase N
XAC_RS16860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAC_RS16870	COG2895	sulfate adenylyltransferase (ATP) activity
XAC_RS16870	COG0529	Catalyzes the synthesis of activated sulfate
XAC_RS16875	COG0175	sulfate reduction
XAC_RS16880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XAC_RS16885	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XAC_RS16890	COG0175	sulfate reduction
XAC_RS16910	COG2198	Histidine kinase
XAC_RS16910	COG0784	Response regulator, receiver
XAC_RS16910	COG2205	protein histidine kinase activity
XAC_RS16945	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XAC_RS16950	COG3588	fructose-bisphosphate aldolase
XAC_RS16955	COG0469	pyruvate kinase activity
XAC_RS16965	COG0126	phosphoglycerate kinase activity
XAC_RS16985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XAC_RS16995	COG3047	cAMP biosynthetic process
XAC_RS17000	COG3047	cAMP biosynthetic process
XAC_RS17010	COG3453	Protein conserved in bacteria
XAC_RS17010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAC_RS17015	COG0725	ABC transporter, periplasmic molybdate-binding protein
XAC_RS17020	COG4149	molybdate abc transporter
XAC_RS17025	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XAC_RS17060	COG1376	ErfK ybiS ycfS ynhG family protein
XAC_RS17065	COG0739	heme binding
XAC_RS17075	COG4773	Receptor
XAC_RS17090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XAC_RS17095	COG1301	dicarboxylic acid transport
XAC_RS17105	COG2304	oxidoreductase activity
XAC_RS17125	COG0714	Associated with various cellular activities
XAC_RS17155	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XAC_RS17180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XAC_RS17190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XAC_RS17200	COG0194	GDP metabolic process
XAC_RS17205	COG1561	YicC-like family, N-terminal region
XAC_RS17210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XAC_RS17220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XAC_RS17225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XAC_RS17240	COG0006	proline dipeptidase activity
XAC_RS17250	COG0006	proline dipeptidase activity
XAC_RS17255	COG3079	Belongs to the UPF0149 family
XAC_RS17270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XAC_RS17280	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XAC_RS17290	COG2912	Transglutaminase-like superfamily
XAC_RS17295	COG1773	rubredoxin
XAC_RS17300	COG0352	thiamine-phosphate diphosphorylase activity
XAC_RS17315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XAC_RS17330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAC_RS17360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XAC_RS17365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAC_RS17370	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS17380	COG0671	phosphoesterase, PA-phosphatase related
XAC_RS17385	COG3781	membrane
XAC_RS17395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XAC_RS17400	COG0563	adenylate kinase activity
XAC_RS17415	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XAC_RS17425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XAC_RS17445	COG3710	Transcriptional regulator
XAC_RS17450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XAC_RS17460	COG0840	transmembrane signaling receptor activity
XAC_RS17465	COG0405	Gamma-glutamyltransferase
XAC_RS17470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XAC_RS17490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XAC_RS17495	COG0473	3-isopropylmalate dehydrogenase activity
XAC_RS17500	COG0066	3-isopropylmalate dehydratase activity
XAC_RS17505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XAC_RS17525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XAC_RS17530	COG1538	Outer membrane efflux protein
XAC_RS17535	COG1519	Transferase
XAC_RS17540	COG1560	Kdo2-lipid A biosynthetic process
XAC_RS17565	COG0280	phosphate acetyltransferase
XAC_RS17565	COG0281	malic enzyme
XAC_RS17570	COG1301	dicarboxylic acid transport
XAC_RS17595	COG0583	DNA-binding transcription factor activity
XAC_RS17600	COG0667	Aldo Keto reductase
XAC_RS17615	COG2197	response regulator
XAC_RS17625	COG0642	Histidine kinase
XAC_RS17640	COG2851	Citrate transporter
XAC_RS17645	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS17650	COG1609	Transcriptional regulator
XAC_RS17655	COG2211	Major facilitator Superfamily
XAC_RS17680	COG1162	GTPase activity
XAC_RS17700	COG4773	Receptor
XAC_RS17705	COG0726	polysaccharide deacetylase
XAC_RS17710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XAC_RS17725	COG2963	transposase activity
XAC_RS17730	COG2801	Transposase and inactivated derivatives
XAC_RS17745	COG1307	EDD domain protein, DegV family
XAC_RS17750	COG0242	peptide deformylase activity
XAC_RS17770	COG0457	Tetratricopeptide repeat
XAC_RS17775	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XAC_RS17780	COG1215	transferase activity, transferring glycosyl groups
XAC_RS17785	COG1215	transferase activity, transferring glycosyl groups
XAC_RS17800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XAC_RS17855	COG2188	Transcriptional regulator
XAC_RS17865	COG1450	Type ii and iii secretion system protein
XAC_RS17880	COG3166	PFAM Fimbrial assembly family protein
XAC_RS17885	COG3156	type II secretion system protein K
XAC_RS17890	COG4795	General secretion pathway protein
XAC_RS17895	COG2165	general secretion pathway protein
XAC_RS17900	COG4970	Tfp pilus assembly protein FimT
XAC_RS17905	COG2165	general secretion pathway protein
XAC_RS17910	COG1459	type II secretion system
XAC_RS17915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XAC_RS17920	COG1404	Belongs to the peptidase S8 family
XAC_RS17925	COG5295	Hep Hag repeat protein
XAC_RS17930	COG1404	Belongs to the peptidase S8 family
XAC_RS17935	COG5295	Hep Hag repeat protein
XAC_RS17945	COG0047	phosphoribosylformylglycinamidine synthase activity
XAC_RS17945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XAC_RS17950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XAC_RS17955	COG4974	Belongs to the 'phage' integrase family
XAC_RS17970	COG0795	lipopolysaccharide-transporting ATPase activity
XAC_RS17980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XAC_RS17995	COG0525	valine-tRNA ligase activity
XAC_RS18025	COG1183	phosphatidylcholine synthase activity
XAC_RS18035	COG0442	prolyl-tRNA aminoacylation
XAC_RS18050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XAC_RS18055	COG1127	ABC transporter
XAC_RS18060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XAC_RS18060	COG3218	ABC-type transport auxiliary lipoprotein component
XAC_RS18095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XAC_RS18100	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XAC_RS18100	COG0662	Cupin 2, conserved barrel domain protein
XAC_RS18130	COG2086	electron transfer activity
XAC_RS18145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XAC_RS18145	COG0546	phosphoglycolate phosphatase activity
XAC_RS18150	COG0277	FAD linked oxidase domain protein
XAC_RS18165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAC_RS18195	COG1216	Glycosyl transferase, family 2
XAC_RS18195	COG0438	transferase activity, transferring glycosyl groups
XAC_RS18215	COG0626	cystathionine gamma-synthase activity
XAC_RS18250	COG0625	glutathione transferase activity
XAC_RS18260	COG0513	Belongs to the DEAD box helicase family
XAC_RS18270	COG4206	TonB-dependent receptor
XAC_RS18275	COG0720	synthase
XAC_RS18285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XAC_RS18295	COG1956	GAF domain-containing protein
XAC_RS18305	COG2819	hydrolase of the alpha beta superfamily
XAC_RS18320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XAC_RS18325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAC_RS18340	COG0339	signal peptide processing
XAC_RS18390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XAC_RS18395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC_RS18400	COG4591	ABC-type transport system involved in lipoprotein release permease component
XAC_RS18400	COG1136	(ABC) transporter
XAC_RS18405	COG0577	efflux transmembrane transporter activity
XAC_RS18405	COG1136	(ABC) transporter
XAC_RS18410	COG0577	efflux transmembrane transporter activity
XAC_RS18425	COG4191	Histidine kinase
XAC_RS18430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XAC_RS18445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XAC_RS18450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XAC_RS18455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XAC_RS18460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XAC_RS18465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XAC_RS18470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XAC_RS18480	COG0356	it plays a direct role in the translocation of protons across the membrane
XAC_RS18500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XAC_RS18510	COG0508	dehydrogenase complex catalyzes the overall conversion of
XAC_RS18555	COG2011	ABC-type metal ion transport system permease component
XAC_RS18560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XAC_RS18565	COG0697	spore germination
XAC_RS18570	COG1666	GTP binding
XAC_RS18580	COG2198	Histidine kinase
XAC_RS18580	COG5002	protein histidine kinase activity
XAC_RS18580	COG0784	Response regulator, receiver
XAC_RS18605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XAC_RS18610	COG1187	pseudouridine synthase activity
XAC_RS18615	COG2813	Specifically methylates the guanine in position
XAC_RS18635	COG2202	Pas domain
XAC_RS18635	COG2205	protein histidine kinase activity
XAC_RS18655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XAC_RS18660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC_RS18715	COG0842	Transport permease protein
XAC_RS18720	COG1131	(ABC) transporter
XAC_RS18725	COG0025	NhaP-type Na H and K H
XAC_RS18730	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XAC_RS18735	COG1573	uracil-dna glycosylase
XAC_RS18745	COG3384	dioxygenase
XAC_RS18755	COG0583	DNA-binding transcription factor activity
XAC_RS18765	COG0667	Aldo Keto reductase
XAC_RS18775	COG3590	peptidase
XAC_RS18795	COG0531	amino acid
XAC_RS18810	COG2972	Histidine kinase
XAC_RS18825	COG3685	Protein conserved in bacteria
XAC_RS18830	COG3546	catalase activity
XAC_RS18875	COG1271	oxidase subunit
XAC_RS18880	COG1294	oxidase, subunit
XAC_RS18895	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS18900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XAC_RS18920	COG1132	(ABC) transporter
XAC_RS18935	COG1063	alcohol dehydrogenase
XAC_RS19010	COG0251	oxidation-reduction process
XAC_RS19040	COG0840	transmembrane signaling receptor activity
XAC_RS19060	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XAC_RS19100	COG0024	Methionine aminopeptidase
XAC_RS19120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XAC_RS19125	COG1490	D-aminoacyl-tRNA deacylase activity
XAC_RS19130	COG1560	Kdo2-lipid A biosynthetic process
XAC_RS19180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XAC_RS19180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XAC_RS19185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XAC_RS19190	COG0242	peptide deformylase activity
XAC_RS19195	COG1652	LysM domain
XAC_RS19200	COG0758	DNA mediated transformation
XAC_RS19205	COG2922	Belongs to the Smg family
XAC_RS19220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XAC_RS19220	COG1754	DNA topoisomerase type I activity
XAC_RS19225	COG0009	L-threonylcarbamoyladenylate synthase
XAC_RS19240	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS19250	COG0616	signal peptide processing
XAC_RS19255	COG0534	Mate efflux family protein
XAC_RS19275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XAC_RS19280	COG0625	glutathione transferase activity
XAC_RS19295	COG1252	NADH dehydrogenase
XAC_RS19300	COG2860	membrane
XAC_RS19305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XAC_RS19310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XAC_RS19315	COG2201	protein-glutamate methylesterase activity
XAC_RS19320	COG2177	Part of the ABC transporter FtsEX involved in
XAC_RS19325	COG2884	Cell division ATP-binding protein ftsE
XAC_RS19330	COG0513	Belongs to the DEAD box helicase family
XAC_RS19335	COG3118	belongs to the thioredoxin family
XAC_RS19340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XAC_RS19345	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XAC_RS19350	COG0583	DNA-binding transcription factor activity
XAC_RS19395	COG1518	maintenance of DNA repeat elements
XAC_RS19400	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
XAC_RS19410	COG1652	LysM domain
XAC_RS19415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XAC_RS19415	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XAC_RS19420	COG1473	amidohydrolase
XAC_RS19425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC_RS19430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAC_RS19440	COG5383	Protein conserved in bacteria
XAC_RS19480	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XAC_RS19485	COG3023	N-Acetylmuramoyl-L-alanine amidase
XAC_RS19495	COG4948	Mandelate Racemase Muconate Lactonizing
XAC_RS19505	COG0531	amino acid
XAC_RS19520	COG4682	membrane
XAC_RS19525	COG2133	pyrroloquinoline quinone binding
XAC_RS19535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XAC_RS19540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XAC_RS19550	COG1610	YqeY-like protein
XAC_RS19555	COG1295	ribonuclease BN
XAC_RS19560	COG0358	DNA primase activity
XAC_RS19575	COG0109	protoheme IX farnesyltransferase activity
XAC_RS19605	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XAC_RS19620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XAC_RS19660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XAC_RS19665	COG0739	heme binding
XAC_RS19670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XAC_RS19680	COG2223	nitrite transmembrane transporter activity
XAC_RS19685	COG0708	Exodeoxyribonuclease III
XAC_RS19690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XAC_RS19700	COG1192	Involved in chromosome partitioning
XAC_RS19705	COG1475	DNA binding
XAC_RS19720	COG0463	Glycosyl transferase, family 2
XAC_RS19740	COG0756	dUTP diphosphatase activity
XAC_RS19745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XAC_RS19750	COG2003	Belongs to the UPF0758 family
XAC_RS19755	COG0018	arginyl-trna synthetase
XAC_RS19770	COG4221	oxidoreductase activity
XAC_RS19775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XAC_RS19775	COG2755	lipolytic protein G-D-S-L family
XAC_RS19785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XAC_RS19795	COG1166	arginine decarboxylase activity
XAC_RS19800	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XAC_RS19840	COG0606	chelatase, subunit chli
XAC_RS19935	COG0606	chelatase, subunit chli
XAC_RS19950	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XAC_RS19985	COG1690	Belongs to the RtcB family
XAC_RS20025	COG1090	epimerase
XAC_RS20035	COG0642	Histidine kinase
XAC_RS20055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XAC_RS20080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XAC_RS20085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XAC_RS20100	COG0753	catalase activity
XAC_RS20115	COG2197	response regulator
XAC_RS20120	COG4585	Histidine kinase
XAC_RS20125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC_RS20130	COG1136	(ABC) transporter
XAC_RS20155	COG0697	spore germination
XAC_RS20170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAC_RS20175	COG0180	Tryptophanyl-tRNA synthetase
XAC_RS20180	COG3237	CsbD-like
XAC_RS20220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XAC_RS20235	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XAC_RS20280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XAC_RS20305	COG1199	ATP-dependent helicase activity
XAC_RS20320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XAC_RS20380	COG0625	glutathione transferase activity
XAC_RS20420	COG4555	ABC transporter
XAC_RS20430	COG1476	TRANSCRIPTIONal
XAC_RS20475	COG0543	2 iron, 2 sulfur cluster binding
XAC_RS20475	COG0633	Ferredoxin
XAC_RS20480	COG1131	(ABC) transporter
XAC_RS20485	COG0842	Transport permease protein
XAC_RS20495	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XAC_RS20525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XAC_RS20530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XAC_RS20540	COG1042	CoA-binding domain protein
XAC_RS20540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XAC_RS20540	COG0045	succinate-CoA ligase (ADP-forming) activity
XAC_RS20545	COG2239	Acts as a magnesium transporter
XAC_RS20550	COG3338	carbonate dehydratase activity
XAC_RS20560	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XAC_RS20565	COG3387	PFAM Glycoside hydrolase 15-related
XAC_RS20580	COG3100	YcgL domain-containing protein
XAC_RS20585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XAC_RS20595	COG0463	Glycosyl transferase, family 2
XAC_RS20610	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS20650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAC_RS20665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XAC_RS20690	COG4946	Tricorn protease homolog
XAC_RS20690	COG0823	Involved in the tonB-independent uptake of proteins
XAC_RS20690	COG1506	peptidase
XAC_RS20705	COG0408	coproporphyrinogen oxidase activity
XAC_RS20740	COG0515	serine threonine protein kinase
XAC_RS20740	COG2815	serine threonine protein kinase
XAC_RS20745	COG0631	protein serine/threonine phosphatase activity
XAC_RS20905	COG0210	DNA helicase
XAC_RS20920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC_RS20925	COG0583	DNA-binding transcription factor activity
XAC_RS20930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XAC_RS20940	COG2159	amidohydrolase
XAC_RS20960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC_RS20980	COG0357	Ribosomal RNA small subunit methyltransferase G
XAC_RS20985	COG3540	Alkaline phosphatase
XAC_RS20995	COG2091	lysine biosynthetic process via aminoadipic acid
XAC_RS21015	COG0708	Exodeoxyribonuclease III
XAC_RS21020	COG1846	Transcriptional regulator
XAC_RS21020	COG1940	carbohydrate kinase activity
XAC_RS21030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAC_RS21040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XAC_RS21045	COG3162	membrane
XAC_RS21055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XAC_RS21085	COG3507	Belongs to the glycosyl hydrolase 43 family
XAC_RS21105	COG1028	Short-chain dehydrogenase reductase Sdr
XAC_RS21110	COG0179	Fumarylacetoacetate (FAA) hydrolase
XAC_RS21115	COG4948	Mandelate Racemase Muconate Lactonizing
XAC_RS21125	COG3254	rhamnose metabolic process
XAC_RS21130	COG0738	Major facilitator superfamily
XAC_RS21135	COG1414	Transcriptional regulator
XAC_RS21140	COG1971	Probably functions as a manganese efflux pump
XAC_RS21145	COG2205	protein histidine kinase activity
XAC_RS21160	COG3459	Glycosyltransferase 36 associated
XAC_RS21165	COG2211	Major facilitator Superfamily
XAC_RS21170	COG3265	gluconokinase activity
XAC_RS21175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAC_RS21195	COG2911	Protein conserved in bacteria
XAC_RS21200	COG0729	surface antigen
XAC_RS21240	COG0752	glycyl-tRNA synthetase alpha subunit
XAC_RS21245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XAC_RS21255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XAC_RS21255	COG0519	Catalyzes the synthesis of GMP from XMP
XAC_RS21265	COG0805	protein transport
XAC_RS21270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XAC_RS21275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XAC_RS21285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XAC_RS21305	COG2974	May be involved in recombination
XAC_RS21310	COG0037	tRNA processing
XAC_RS21315	COG2115	Belongs to the xylose isomerase family
XAC_RS21325	COG3661	Belongs to the glycosyl hydrolase 67 family
XAC_RS21335	COG4948	Mandelate Racemase Muconate Lactonizing
XAC_RS21345	COG1472	Belongs to the glycosyl hydrolase 3 family
XAC_RS21350	COG0246	Mannitol dehydrogenase
XAC_RS21430	COG3386	PFAM SMP-30 Gluconolaconase
XAC_RS21440	COG3250	beta-galactosidase activity
XAC_RS21445	COG1904	glucuronate isomerase
XAC_RS21450	COG3693	PFAM glycoside hydrolase, family 10
XAC_RS21465	COG3693	PFAM glycoside hydrolase, family 10
XAC_RS21480	COG2211	Major facilitator Superfamily
XAC_RS21525	COG2937	Belongs to the GPAT DAPAT family
XAC_RS21560	COG0284	orotidine-5'-phosphate decarboxylase activity
XAC_RS21565	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XAC_RS21570	COG3132	Protein of unknown function, DUF480
XAC_RS21585	COG0210	DNA helicase
XAC_RS21590	COG1435	thymidine kinase activity
XAC_RS21600	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XAC_RS21610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XAC_RS21640	COG3135	benzoate transporter
XAC_RS21660	COG0676	glucose-6-phosphate 1-epimerase activity
XAC_RS21670	COG3012	SEC-C Motif Domain Protein
XAC_RS21675	COG0730	response to heat
XAC_RS21695	COG0302	gtp cyclohydrolase
XAC_RS21710	COG1566	PFAM secretion protein HlyD family protein
XAC_RS21720	COG1289	transmembrane transporter activity
XAC_RS21725	COG0477	Major facilitator Superfamily
XAC_RS21735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC_RS21755	COG4691	Plasmid stability protein
XAC_RS21760	COG1487	ribonuclease activity
XAC_RS21785	COG0564	pseudouridine synthase activity
XAC_RS21820	COG0439	Biotin carboxylase
XAC_RS21860	COG1074	ATP-dependent DNA helicase activity
XAC_RS21865	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XAC_RS21880	COG1127	ABC transporter
XAC_RS21885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XAC_RS21890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XAC_RS21905	COG2853	Lipoprotein
XAC_RS21915	COG0386	Belongs to the glutathione peroxidase family
XAC_RS21925	COG1322	Protein conserved in bacteria
XAC_RS21930	COG0604	alcohol dehydrogenase
XAC_RS21950	COG0625	glutathione transferase activity
XAC_RS21960	COG0531	amino acid
XAC_RS21965	COG3537	Alpha-1,2-mannosidase
XAC_RS21975	COG3706	GGDEF domain
XAC_RS21980	COG3835	regulator
XAC_RS21985	COG1929	Belongs to the glycerate kinase type-1 family
XAC_RS21990	COG2271	Major facilitator Superfamily
XAC_RS22005	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XAC_RS22010	COG0861	Integral membrane protein TerC family
XAC_RS22020	COG0584	glycerophosphoryl diester phosphodiesterase
XAC_RS22035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XAC_RS22040	COG0726	polysaccharide deacetylase
XAC_RS22045	COG0706	membrane insertase activity
XAC_RS22050	COG0594	ribonuclease P activity
XAC_RS22245	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC_RS22385	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC_RS22430	COG0493	'glutamate synthase
XAC_RS22445	COG0070	glutamate synthase
XAC_RS22445	COG0067	glutamate synthase
XAC_RS22445	COG0069	glutamate synthase activity
XAC_RS22455	COG0067	glutamate synthase
XAC_RS22455	COG0070	glutamate synthase
XAC_RS22455	COG0069	glutamate synthase activity
XAC_RS22555	COG0367	asparagine synthase