locus-tag	class	description
XACM_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XACM_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XACM_RS00020	COG0187	DNA topoisomerase II activity
XACM_RS00030	COG0501	Belongs to the peptidase M48B family
XACM_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XACM_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XACM_RS00120	COG0793	Belongs to the peptidase S41A family
XACM_RS00125	COG4942	peptidase
XACM_RS00135	COG2234	aminopeptidase activity
XACM_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XACM_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XACM_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XACM_RS00165	COG1064	alcohol dehydrogenase
XACM_RS00175	COG0493	'glutamate synthase
XACM_RS00180	COG0070	glutamate synthase
XACM_RS00180	COG0069	glutamate synthase activity
XACM_RS00180	COG0067	glutamate synthase
XACM_RS00260	COG1111	helicase
XACM_RS00260	COG1205	dead DEAH box helicase
XACM_RS00265	COG1272	protein, Hemolysin III
XACM_RS00280	COG0300	oxidoreductase activity
XACM_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS00305	COG2249	NAD(P)H dehydrogenase (quinone) activity
XACM_RS00310	COG2801	Transposase and inactivated derivatives
XACM_RS00315	COG2963	transposase activity
XACM_RS00325	COG2801	Transposase and inactivated derivatives
XACM_RS00330	COG2963	transposase activity
XACM_RS00345	COG3237	CsbD-like
XACM_RS00395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XACM_RS00400	COG0477	Major facilitator Superfamily
XACM_RS00440	COG0714	Associated with various cellular activities
XACM_RS00485	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XACM_RS00495	COG4772	TonB-dependent receptor
XACM_RS00510	COG1012	belongs to the aldehyde dehydrogenase family
XACM_RS00535	COG1304	FMN binding
XACM_RS00550	COG1755	Isoprenylcysteine carboxyl methyltransferase
XACM_RS00555	COG4585	Histidine kinase
XACM_RS00560	COG2197	response regulator
XACM_RS00570	COG3710	Transcriptional regulator
XACM_RS00575	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XACM_RS00585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XACM_RS00620	COG2963	transposase activity
XACM_RS00625	COG2801	Transposase and inactivated derivatives
XACM_RS00645	COG0366	Alpha amylase catalytic
XACM_RS00650	COG0366	Alpha amylase catalytic
XACM_RS00655	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XACM_RS00670	COG2272	Belongs to the type-B carboxylesterase lipase family
XACM_RS00675	COG0657	acetylesterase activity
XACM_RS00675	COG2755	lipolytic protein G-D-S-L family
XACM_RS00685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XACM_RS00700	COG3507	Belongs to the glycosyl hydrolase 43 family
XACM_RS00705	COG1609	Transcriptional regulator
XACM_RS00710	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XACM_RS00715	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS00725	COG2755	lipolytic protein G-D-S-L family
XACM_RS00735	COG3186	Phenylalanine-4-hydroxylase
XACM_RS00740	COG1522	sequence-specific DNA binding
XACM_RS00750	COG1752	Esterase of the alpha-beta hydrolase superfamily
XACM_RS00755	COG1473	amidohydrolase
XACM_RS00765	COG1119	ATPase activity
XACM_RS00780	COG1125	glycine betaine transport
XACM_RS00795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XACM_RS00830	COG0489	protein tyrosine kinase activity
XACM_RS00835	COG2062	phosphohistidine phosphatase, SixA
XACM_RS00845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XACM_RS00890	COG1968	undecaprenyl-diphosphatase activity
XACM_RS00895	COG0174	glutamine synthetase
XACM_RS00900	COG0347	Belongs to the P(II) protein family
XACM_RS00905	COG0004	ammonium transporteR
XACM_RS00910	COG3852	Histidine kinase
XACM_RS00915	COG2204	response regulator
XACM_RS00920	COG2032	superoxide dismutase activity
XACM_RS00925	COG2032	superoxide dismutase activity
XACM_RS00930	COG0346	lactoylglutathione lyase activity
XACM_RS00940	COG0183	Belongs to the thiolase family
XACM_RS00975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XACM_RS00980	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XACM_RS00985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XACM_RS00995	COG0028	Belongs to the TPP enzyme family
XACM_RS01000	COG2205	protein histidine kinase activity
XACM_RS01025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XACM_RS01040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XACM_RS01045	COG3177	Filamentation induced by cAMP protein fic
XACM_RS01050	COG0596	Alpha beta hydrolase
XACM_RS01055	COG0727	PFAM Uncharacterised protein family (UPF0153)
XACM_RS01060	COG0318	PFAM AMP-dependent synthetase and ligase
XACM_RS01065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XACM_RS01075	COG1181	Belongs to the D-alanine--D-alanine ligase family
XACM_RS01090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XACM_RS01100	COG0564	pseudouridine synthase activity
XACM_RS01120	COG1446	asparaginase
XACM_RS01125	COG0339	signal peptide processing
XACM_RS01155	COG0475	glutathione-regulated potassium exporter activity
XACM_RS01160	COG0583	DNA-binding transcription factor activity
XACM_RS01165	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XACM_RS01170	COG2224	Isocitrate lyase
XACM_RS01200	COG4770	biotin carboxylase activity
XACM_RS01205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XACM_RS01210	COG1960	acyl-CoA dehydrogenase activity
XACM_RS01265	COG0523	cobalamin synthesis protein
XACM_RS01280	COG0697	spore germination
XACM_RS01290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XACM_RS01295	COG1846	Transcriptional regulator
XACM_RS01300	COG1764	response to oxidative stress
XACM_RS01320	COG2130	NADP-dependent
XACM_RS01335	COG1187	pseudouridine synthase activity
XACM_RS01345	COG1643	Atp-dependent helicase
XACM_RS01355	COG4807	Protein conserved in bacteria
XACM_RS01360	COG2351	hydroxyisourate hydrolase activity
XACM_RS01365	COG2072	flavoprotein involved in K transport
XACM_RS01385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XACM_RS01400	COG0583	DNA-binding transcription factor activity
XACM_RS01435	COG2252	PERMEase
XACM_RS01455	COG0084	hydrolase, TatD family'
XACM_RS01470	COG0583	DNA-binding transcription factor activity
XACM_RS01475	COG2814	Major facilitator Superfamily
XACM_RS01485	COG2267	carboxylic ester hydrolase activity
XACM_RS01490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XACM_RS01495	COG1902	pentaerythritol trinitrate reductase activity
XACM_RS01515	COG0745	RESPONSE REGULATOR receiver
XACM_RS01520	COG2205	protein histidine kinase activity
XACM_RS01525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_RS01550	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XACM_RS01555	COG0583	DNA-binding transcription factor activity
XACM_RS01590	COG0702	epimerase
XACM_RS01595	COG1733	regulation of RNA biosynthetic process
XACM_RS01605	COG2801	Transposase and inactivated derivatives
XACM_RS01610	COG2963	transposase activity
XACM_RS01635	COG0129	dihydroxy-acid dehydratase activity
XACM_RS01655	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XACM_RS01710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XACM_RS01715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XACM_RS01740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XACM_RS01745	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XACM_RS01755	COG3485	protocatechuate 3,4-dioxygenase
XACM_RS01760	COG3485	protocatechuate 3,4-dioxygenase
XACM_RS01770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XACM_RS01775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XACM_RS01785	COG1414	Transcriptional regulator
XACM_RS01795	COG0657	acetylesterase activity
XACM_RS01805	COG0445	tRNA wobble uridine modification
XACM_RS01815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XACM_RS01840	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS01845	COG2267	carboxylic ester hydrolase activity
XACM_RS01855	COG0156	8-amino-7-oxononanoate synthase activity
XACM_RS01860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XACM_RS01865	COG1040	competence protein
XACM_RS01870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XACM_RS01955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XACM_RS02025	COG3264	Mechanosensitive ion channel
XACM_RS02025	COG1511	domain protein
XACM_RS02030	COG1368	sulfuric ester hydrolase activity
XACM_RS02035	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XACM_RS02040	COG2354	Protein conserved in bacteria
XACM_RS02050	COG0297	glycogen (starch) synthase activity
XACM_RS02055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XACM_RS02060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XACM_RS02085	COG0702	epimerase
XACM_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS02125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XACM_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS02140	COG0513	Belongs to the DEAD box helicase family
XACM_RS02145	COG0508	dehydrogenase complex catalyzes the overall conversion of
XACM_RS02160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XACM_RS02170	COG3483	tryptophan 2,3-dioxygenase activity
XACM_RS02175	COG3104	oligopeptide transport
XACM_RS02195	COG2852	Protein conserved in bacteria
XACM_RS02200	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XACM_RS02215	COG1320	monovalent cation:proton antiporter activity
XACM_RS02220	COG2212	antiporter activity
XACM_RS02230	COG0651	ATP synthesis coupled electron transport
XACM_RS02235	COG1006	Multisubunit Na H antiporter MnhC subunit
XACM_RS02240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XACM_RS02240	COG2111	Na H antiporter
XACM_RS02260	COG3179	chitinase
XACM_RS02280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XACM_RS02285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XACM_RS02290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
XACM_RS02295	COG0456	acetyltransferase
XACM_RS02300	COG1597	lipid kinase activity
XACM_RS02330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XACM_RS02335	COG0134	indole-3-glycerol-phosphate synthase activity
XACM_RS02345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XACM_RS02350	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XACM_RS02360	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XACM_RS02370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XACM_RS02385	COG1051	belongs to the nudix hydrolase family
XACM_RS02425	COG0316	Belongs to the HesB IscA family
XACM_RS02440	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XACM_RS02465	COG2814	Major facilitator Superfamily
XACM_RS02470	COG1289	transmembrane transporter activity
XACM_RS02475	COG0151	Belongs to the GarS family
XACM_RS02485	COG0138	bifunctional purine biosynthesis protein purh
XACM_RS02490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XACM_RS02495	COG2267	carboxylic ester hydrolase activity
XACM_RS02500	COG0671	phosphoesterase, PA-phosphatase related
XACM_RS02500	COG2453	phosphatase
XACM_RS02525	COG4589	Belongs to the CDS family
XACM_RS02530	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XACM_RS02555	COG2264	protein methyltransferase activity
XACM_RS02570	COG0439	Biotin carboxylase
XACM_RS02580	COG0511	ligase activity, forming carbon-carbon bonds
XACM_RS02585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XACM_RS02595	COG1324	tolerance protein
XACM_RS02600	COG2356	endonuclease I
XACM_RS02610	COG0459	protein refolding
XACM_RS02625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XACM_RS02655	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XACM_RS02660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XACM_RS02685	COG0778	Nitroreductase
XACM_RS02690	COG2353	YceI-like domain
XACM_RS02720	COG3052	prosthetic group binding
XACM_RS02745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XACM_RS02755	COG1802	Transcriptional regulator
XACM_RS02760	COG0546	phosphoglycolate phosphatase activity
XACM_RS02820	COG2963	transposase activity
XACM_RS02825	COG2801	Transposase and inactivated derivatives
XACM_RS02870	COG0435	Glutathione S-transferase
XACM_RS02895	COG2409	Drug exporters of the RND superfamily
XACM_RS02920	COG1959	2 iron, 2 sulfur cluster binding
XACM_RS02945	COG0697	spore germination
XACM_RS02960	COG1113	amino acid transport
XACM_RS02970	COG0598	Magnesium transport protein CorA
XACM_RS02985	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XACM_RS03015	COG5001	Diguanylate cyclase
XACM_RS03020	COG0840	transmembrane signaling receptor activity
XACM_RS03025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XACM_RS03025	COG5297	Belongs to the glycosyl hydrolase family 6
XACM_RS03030	COG0659	secondary active sulfate transmembrane transporter activity
XACM_RS03045	COG2943	transferase activity, transferring hexosyl groups
XACM_RS03055	COG3275	phosphorelay sensor kinase activity
XACM_RS03065	COG0181	hydroxymethylbilane synthase activity
XACM_RS03100	COG1505	serine-type exopeptidase activity
XACM_RS03105	COG0436	Aminotransferase
XACM_RS03115	COG2832	Protein of unknown function (DUF454)
XACM_RS03125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XACM_RS03135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XACM_RS03140	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XACM_RS03145	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XACM_RS03175	COG3300	MHYT domain
XACM_RS03175	COG5001	Diguanylate cyclase
XACM_RS03180	COG0308	aminopeptidase N
XACM_RS03215	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
XACM_RS03225	COG3284	Transcriptional regulator
XACM_RS03230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XACM_RS03235	COG1077	Cell shape determining protein MreB Mrl
XACM_RS03240	COG1792	Involved in formation and maintenance of cell shape
XACM_RS03255	COG0772	Belongs to the SEDS family
XACM_RS03265	COG2951	lytic endotransglycosylase activity
XACM_RS03270	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XACM_RS03280	COG1686	Belongs to the peptidase S11 family
XACM_RS03295	COG2921	Belongs to the UPF0250 family
XACM_RS03300	COG0321	lipoyl(octanoyl) transferase activity
XACM_RS03305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XACM_RS03320	COG0583	DNA-binding transcription factor activity
XACM_RS03330	COG1051	belongs to the nudix hydrolase family
XACM_RS03330	COG1056	cytidyltransferase-related domain
XACM_RS03365	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XACM_RS03370	COG0673	inositol 2-dehydrogenase activity
XACM_RS03375	COG2823	Periplasmic or secreted lipoprotein
XACM_RS03380	COG4251	negative regulation of phosphorylation
XACM_RS03385	COG0784	Response regulator, receiver
XACM_RS03390	COG4191	Histidine kinase
XACM_RS03395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XACM_RS03450	COG1459	type II secretion system
XACM_RS03470	COG4795	General secretion pathway protein
XACM_RS03495	COG2188	Transcriptional regulator
XACM_RS03505	COG1609	Transcriptional regulator
XACM_RS03510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XACM_RS03515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XACM_RS03525	COG0617	tRNA 3'-terminal CCA addition
XACM_RS03530	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XACM_RS03535	COG1012	belongs to the aldehyde dehydrogenase family
XACM_RS03540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XACM_RS03565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XACM_RS03580	COG2205	protein histidine kinase activity
XACM_RS03610	COG3791	Glutathione-dependent formaldehyde-activating
XACM_RS03625	COG0488	(ABC) transporter
XACM_RS03635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XACM_RS03645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XACM_RS03655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XACM_RS03655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XACM_RS03675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XACM_RS03680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XACM_RS03685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XACM_RS03705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XACM_RS03710	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XACM_RS03720	COG2205	protein histidine kinase activity
XACM_RS03725	COG0745	RESPONSE REGULATOR receiver
XACM_RS03730	COG0277	FAD linked oxidase domain protein
XACM_RS03735	COG1988	membrane-bound metal-dependent
XACM_RS03740	COG0792	nuclease activity
XACM_RS03775	COG0275	rRNA processing
XACM_RS03780	COG3116	cell division
XACM_RS03795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XACM_RS03800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XACM_RS03805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XACM_RS03815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XACM_RS03820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XACM_RS03825	COG1181	Belongs to the D-alanine--D-alanine ligase family
XACM_RS03830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XACM_RS03845	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XACM_RS03855	COG0739	heme binding
XACM_RS03860	COG0653	protein targeting
XACM_RS03865	COG0494	nUDIX hydrolase
XACM_RS03875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XACM_RS03885	COG3321	synthase
XACM_RS03885	COG0604	alcohol dehydrogenase
XACM_RS03885	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS03905	COG0366	Alpha amylase catalytic
XACM_RS03935	COG2226	methyltransferase
XACM_RS03940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XACM_RS03950	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XACM_RS03990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XACM_RS04000	COG4106	trans-aconitate 2-methyltransferase activity
XACM_RS04005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XACM_RS04015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XACM_RS04020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XACM_RS04025	COG0667	Aldo Keto reductase
XACM_RS04035	COG4771	TonB-dependent receptor
XACM_RS04060	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XACM_RS04070	COG2175	clavaminate synthase activity
XACM_RS04080	COG4181	ATPase activity
XACM_RS04095	COG0642	Histidine kinase
XACM_RS04105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XACM_RS04125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XACM_RS04130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XACM_RS04140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XACM_RS04145	COG2967	ApaG domain
XACM_RS04150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XACM_RS04155	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XACM_RS04160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XACM_RS04165	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XACM_RS04170	COG0123	including yeast histone deacetylase and acetoin utilization protein
XACM_RS04175	COG2096	Adenosyltransferase
XACM_RS04185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XACM_RS04190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XACM_RS04220	COG3384	dioxygenase
XACM_RS04225	COG0583	DNA-binding transcription factor activity
XACM_RS04230	COG0318	PFAM AMP-dependent synthetase and ligase
XACM_RS04240	COG1024	Enoyl-CoA hydratase
XACM_RS04260	COG3386	PFAM SMP-30 Gluconolaconase
XACM_RS04270	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XACM_RS04295	COG0697	spore germination
XACM_RS04305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XACM_RS04330	COG2197	response regulator
XACM_RS04340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XACM_RS04350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XACM_RS04355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XACM_RS04360	COG0583	DNA-binding transcription factor activity
XACM_RS04365	COG3634	alkyl hydroperoxide reductase activity
XACM_RS04375	COG2890	protein-(glutamine-N5) methyltransferase activity
XACM_RS04395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XACM_RS04395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XACM_RS04415	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XACM_RS04440	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XACM_RS04455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XACM_RS04460	COG1404	Belongs to the peptidase S8 family
XACM_RS04465	COG1404	Belongs to the peptidase S8 family
XACM_RS04470	COG1404	Belongs to the peptidase S8 family
XACM_RS04475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XACM_RS04500	COG1295	ribonuclease BN
XACM_RS04505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XACM_RS04510	COG1254	Belongs to the acylphosphatase family
XACM_RS04525	COG0521	Mo-molybdopterin cofactor biosynthetic process
XACM_RS04535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XACM_RS04540	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XACM_RS04550	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XACM_RS04555	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XACM_RS04565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XACM_RS04570	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XACM_RS04575	COG0193	aminoacyl-tRNA hydrolase activity
XACM_RS04580	COG0012	GTP binding
XACM_RS04600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XACM_RS04615	COG0250	Participates in transcription elongation, termination and antitermination
XACM_RS04620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XACM_RS04625	COG0081	regulation of translation
XACM_RS04630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XACM_RS04635	COG0222	ribosome binding
XACM_RS04640	COG0085	RNA polymerase activity
XACM_RS04645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XACM_RS04650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XACM_RS04655	COG0049	tRNA binding
XACM_RS04660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XACM_RS04665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XACM_RS04675	COG0051	transcription antitermination factor activity, RNA binding
XACM_RS04680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XACM_RS04685	COG0088	Forms part of the polypeptide exit tunnel
XACM_RS04695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XACM_RS04700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XACM_RS04710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XACM_RS04715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XACM_RS04720	COG0255	Belongs to the universal ribosomal protein uL29 family
XACM_RS04725	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XACM_RS04740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XACM_RS04745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XACM_RS04750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XACM_RS04755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XACM_RS04760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XACM_RS04770	COG1841	ribosomal large subunit assembly
XACM_RS04775	COG0200	Binds to the 23S rRNA
XACM_RS04780	COG0201	protein transport
XACM_RS04805	COG0203	ribosomal protein L17
XACM_RS04810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XACM_RS04830	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XACM_RS04850	COG1217	gtp-binding protein TYPA
XACM_RS04855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XACM_RS04860	COG0039	L-malate dehydrogenase activity
XACM_RS04865	COG0625	glutathione transferase activity
XACM_RS04875	COG0446	pyridine nucleotide-disulphide oxidoreductase
XACM_RS04875	COG1902	pentaerythritol trinitrate reductase activity
XACM_RS04880	COG0604	alcohol dehydrogenase
XACM_RS04885	COG2885	chlorophyll binding
XACM_RS04905	COG0156	8-amino-7-oxononanoate synthase activity
XACM_RS04910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XACM_RS04915	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XACM_RS04920	COG4208	sulfate ABC transporter
XACM_RS04925	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XACM_RS04935	COG1063	alcohol dehydrogenase
XACM_RS04955	COG0406	alpha-ribazole phosphatase activity
XACM_RS04960	COG0285	dihydrofolate synthase activity
XACM_RS04980	COG2833	Protein of unknown function (DUF455)
XACM_RS04985	COG3291	Pkd domain containing protein
XACM_RS04995	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XACM_RS05000	COG0671	phosphoesterase, PA-phosphatase related
XACM_RS05005	COG0438	transferase activity, transferring glycosyl groups
XACM_RS05015	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XACM_RS05030	COG4783	chaperone-mediated protein folding
XACM_RS05045	COG0473	3-isopropylmalate dehydrogenase activity
XACM_RS05075	COG3852	Histidine kinase
XACM_RS05085	COG0544	peptidyl-prolyl cis-trans isomerase activity
XACM_RS05095	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XACM_RS05125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XACM_RS05145	COG0328	RNA-DNA hybrid ribonuclease activity
XACM_RS05150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XACM_RS05155	COG0631	protein serine/threonine phosphatase activity
XACM_RS05170	COG0859	PFAM glycosyl transferase family 9
XACM_RS05175	COG3642	lipopolysaccharide core region biosynthetic process
XACM_RS05180	COG1234	tRNA 3'-trailer cleavage
XACM_RS05185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XACM_RS05195	COG0315	cyclic pyranopterin monophosphate synthase activity
XACM_RS05200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XACM_RS05205	COG0314	molybdopterin synthase activity
XACM_RS05250	COG2801	Transposase and inactivated derivatives
XACM_RS05255	COG2963	transposase activity
XACM_RS05290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XACM_RS05295	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XACM_RS05300	COG0537	adenosine 5'-monophosphoramidase activity
XACM_RS05320	COG0714	Associated with various cellular activities
XACM_RS05335	COG0424	maF-like protein
XACM_RS05340	COG1399	metal-binding, possibly nucleic acid-binding protein
XACM_RS05345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XACM_RS05350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XACM_RS05380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XACM_RS05385	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XACM_RS05410	COG3829	transcription factor binding
XACM_RS05435	COG2828	Protein conserved in bacteria
XACM_RS05450	COG2373	Large extracellular alpha-helical protein
XACM_RS05465	COG4953	penicillin-binding protein 1C
XACM_RS05475	COG0678	peroxiredoxin activity
XACM_RS05495	COG0330	HflC and HflK could
XACM_RS05500	COG0330	HflC and HflK could
XACM_RS05510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XACM_RS05515	COG0308	aminopeptidase N
XACM_RS05525	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS05530	COG1309	transcriptional regulator
XACM_RS05620	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XACM_RS05630	COG3387	PFAM Glycoside hydrolase 15-related
XACM_RS05635	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS05640	COG3537	Alpha-1,2-mannosidase
XACM_RS05645	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS05660	COG0492	ferredoxin-NADP+ reductase activity
XACM_RS05685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XACM_RS05690	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XACM_RS05695	COG2080	2 iron, 2 sulfur cluster binding
XACM_RS05730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XACM_RS05750	COG0587	DNA-directed DNA polymerase activity
XACM_RS05765	COG1297	OPT oligopeptide transporter protein
XACM_RS05780	COG1506	peptidase
XACM_RS05780	COG0823	Involved in the tonB-independent uptake of proteins
XACM_RS05795	COG1917	Cupin 2, conserved barrel domain protein
XACM_RS05795	COG2207	Transcriptional regulator
XACM_RS05815	COG0753	catalase activity
XACM_RS05820	COG0656	L-ascorbic acid biosynthetic process
XACM_RS05825	COG2272	Belongs to the type-B carboxylesterase lipase family
XACM_RS05830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XACM_RS05830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XACM_RS05855	COG2814	Major facilitator Superfamily
XACM_RS05870	COG2194	sulfuric ester hydrolase activity
XACM_RS05885	COG0745	RESPONSE REGULATOR receiver
XACM_RS05890	COG0642	Histidine kinase
XACM_RS05900	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XACM_RS05905	COG2894	cell division
XACM_RS05910	COG0850	regulation of cytokinetic process
XACM_RS05920	COG4585	Histidine kinase
XACM_RS05925	COG2197	response regulator
XACM_RS05940	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XACM_RS05965	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XACM_RS05975	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XACM_RS05990	COG1595	DNA-templated transcription, initiation
XACM_RS06000	COG1946	Acyl-CoA thioesterase
XACM_RS06005	COG1024	Enoyl-CoA hydratase
XACM_RS06015	COG0824	Thioesterase
XACM_RS06020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XACM_RS06025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XACM_RS06030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XACM_RS06035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XACM_RS06040	COG0268	Binds directly to 16S ribosomal RNA
XACM_RS06050	COG0196	riboflavin kinase activity
XACM_RS06055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XACM_RS06060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XACM_RS06065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XACM_RS06080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XACM_RS06085	COG1845	cytochrome c oxidase, subunit III
XACM_RS06090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XACM_RS06105	COG3152	Membrane
XACM_RS06115	COG2207	Transcriptional regulator
XACM_RS06120	COG0326	Molecular chaperone. Has ATPase activity
XACM_RS06130	COG1366	Belongs to the anti-sigma-factor antagonist family
XACM_RS06135	COG1366	Belongs to the anti-sigma-factor antagonist family
XACM_RS06140	COG2172	sigma factor antagonist activity
XACM_RS06165	COG4771	TonB-dependent receptor
XACM_RS06175	COG5507	3-demethylubiquinone-9 3-methyltransferase
XACM_RS06180	COG2205	protein histidine kinase activity
XACM_RS06190	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XACM_RS06195	COG4999	Histidine kinase
XACM_RS06195	COG2205	protein histidine kinase activity
XACM_RS06195	COG3437	response regulator, receiver
XACM_RS06195	COG3850	Histidine kinase
XACM_RS06200	COG4191	Histidine kinase
XACM_RS06200	COG0784	Response regulator, receiver
XACM_RS06225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XACM_RS06230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XACM_RS06240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XACM_RS06245	COG0228	four-way junction DNA binding
XACM_RS06250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XACM_RS06255	COG0336	Belongs to the RNA methyltransferase TrmD family
XACM_RS06260	COG0335	large ribosomal subunit rRNA binding
XACM_RS06265	COG0534	Mate efflux family protein
XACM_RS06290	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XACM_RS06300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XACM_RS06310	COG3483	tryptophan 2,3-dioxygenase activity
XACM_RS06320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XACM_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS06335	COG0840	transmembrane signaling receptor activity
XACM_RS06350	COG3250	beta-galactosidase activity
XACM_RS06355	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XACM_RS06375	COG1960	acyl-CoA dehydrogenase activity
XACM_RS06400	COG1250	3-hydroxyacyl-CoA dehydrogenase
XACM_RS06400	COG1024	Enoyl-CoA hydratase
XACM_RS06415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XACM_RS06420	COG0481	GTPase activity
XACM_RS06435	COG0571	ribonuclease III activity
XACM_RS06440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XACM_RS06445	COG1381	Involved in DNA repair and RecF pathway recombination
XACM_RS06455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XACM_RS06460	COG2954	triphosphatase activity
XACM_RS06465	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XACM_RS06475	COG3046	protein related to deoxyribodipyrimidine photolyase
XACM_RS06480	COG1472	Belongs to the glycosyl hydrolase 3 family
XACM_RS06485	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XACM_RS06490	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XACM_RS06495	COG1278	Cold shock
XACM_RS06500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XACM_RS06510	COG1201	RNA secondary structure unwinding
XACM_RS06515	COG1793	dna ligase
XACM_RS06525	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XACM_RS06525	COG1793	dna ligase
XACM_RS06555	COG0183	Belongs to the thiolase family
XACM_RS06575	COG1451	nucleotide metabolic process
XACM_RS06580	COG5487	UPF0391 membrane protein
XACM_RS06590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XACM_RS06615	COG1047	Peptidyl-prolyl cis-trans
XACM_RS06625	COG2824	Alkylphosphonate utilization operon protein PhnA
XACM_RS06630	COG1902	pentaerythritol trinitrate reductase activity
XACM_RS06635	COG2814	Major facilitator Superfamily
XACM_RS06670	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XACM_RS06670	COG0392	lysyltransferase activity
XACM_RS06680	COG0251	oxidation-reduction process
XACM_RS06685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XACM_RS06700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XACM_RS06725	COG1595	DNA-templated transcription, initiation
XACM_RS06745	COG2878	Part of a membrane complex involved in electron transport
XACM_RS06755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XACM_RS06755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XACM_RS06775	COG0346	lactoylglutathione lyase activity
XACM_RS06790	COG0833	amino acid
XACM_RS06795	COG2040	homocysteine
XACM_RS06805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XACM_RS06825	COG1695	Transcriptional regulator
XACM_RS06845	COG1981	membrane
XACM_RS06860	COG0825	malonyl-CoA metabolic process
XACM_RS06875	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XACM_RS06880	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XACM_RS06885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XACM_RS06890	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XACM_RS06905	COG0750	zinc metalloprotease
XACM_RS06910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XACM_RS06915	COG0575	Belongs to the CDS family
XACM_RS06920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XACM_RS06925	COG0233	cytoplasmic translational termination
XACM_RS06930	COG0528	UMP kinase activity
XACM_RS06940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XACM_RS06945	COG0052	Belongs to the universal ribosomal protein uS2 family
XACM_RS06985	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XACM_RS06995	COG1393	Belongs to the ArsC family
XACM_RS07000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XACM_RS07005	COG0367	asparagine synthase
XACM_RS07015	COG4774	siderophore transport
XACM_RS07030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XACM_RS07055	COG1566	PFAM secretion protein HlyD family protein
XACM_RS07060	COG2814	Major facilitator Superfamily
XACM_RS07120	COG0339	signal peptide processing
XACM_RS07125	COG0386	Belongs to the glutathione peroxidase family
XACM_RS07185	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XACM_RS07190	COG0084	hydrolase, TatD family'
XACM_RS07205	COG1960	acyl-CoA dehydrogenase activity
XACM_RS07220	COG0367	asparagine synthase
XACM_RS07230	COG0305	Participates in initiation and elongation during chromosome replication
XACM_RS07235	COG0415	Belongs to the DNA photolyase family
XACM_RS07245	COG0583	DNA-binding transcription factor activity
XACM_RS07290	COG3706	GGDEF domain
XACM_RS07315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XACM_RS07330	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XACM_RS07340	COG0497	DNA recombination
XACM_RS07345	COG1420	regulation of RNA biosynthetic process
XACM_RS07350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XACM_RS07355	COG0443	Heat shock 70 kDa protein
XACM_RS07360	COG0484	heat shock protein binding
XACM_RS07365	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XACM_RS07395	COG0583	DNA-binding transcription factor activity
XACM_RS07400	COG1132	(ABC) transporter
XACM_RS07435	COG2850	peptidyl-arginine hydroxylation
XACM_RS07455	COG1253	flavin adenine dinucleotide binding
XACM_RS07485	COG1131	(ABC) transporter
XACM_RS07490	COG1725	Transcriptional regulator
XACM_RS07495	COG0386	Belongs to the glutathione peroxidase family
XACM_RS07510	COG2900	Belongs to the SlyX family
XACM_RS07535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XACM_RS07545	COG1410	methionine synthase
XACM_RS07545	COG0646	methionine synthase
XACM_RS07550	COG0646	methionine synthase
XACM_RS07550	COG1410	methionine synthase
XACM_RS07555	COG2226	methyltransferase
XACM_RS07560	COG1960	acyl-CoA dehydrogenase activity
XACM_RS07580	COG0557	exoribonuclease II activity
XACM_RS07590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XACM_RS07605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XACM_RS07615	COG0704	Plays a role in the regulation of phosphate uptake
XACM_RS07620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XACM_RS07625	COG0581	inorganic phosphate transmembrane transporter activity
XACM_RS07630	COG0573	inorganic phosphate transmembrane transporter activity
XACM_RS07635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XACM_RS07660	COG0659	secondary active sulfate transmembrane transporter activity
XACM_RS07665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XACM_RS07675	COG1024	Enoyl-CoA hydratase
XACM_RS07685	COG0494	nUDIX hydrolase
XACM_RS07730	COG0116	Belongs to the methyltransferase superfamily
XACM_RS07730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XACM_RS07735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XACM_RS07750	COG0667	Aldo Keto reductase
XACM_RS07760	COG2925	Exonuclease
XACM_RS07765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XACM_RS07770	COG3844	kynureninase activity
XACM_RS07780	COG0662	Cupin 2, conserved barrel domain protein
XACM_RS07785	COG0288	reversible hydration of carbon dioxide
XACM_RS07860	COG0017	Asparaginyl-tRNA synthetase
XACM_RS07865	COG0316	Belongs to the HesB IscA family
XACM_RS07870	COG0360	Binds together with S18 to 16S ribosomal RNA
XACM_RS07875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XACM_RS07880	COG0359	binds to the 23S rRNA
XACM_RS07890	COG3115	cell septum assembly
XACM_RS07900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XACM_RS07905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XACM_RS07910	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XACM_RS07920	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XACM_RS07930	COG4993	Dehydrogenase
XACM_RS07940	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XACM_RS07950	COG2986	histidine ammonia-lyase
XACM_RS07955	COG1228	amidohydrolase
XACM_RS07995	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XACM_RS08000	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XACM_RS08005	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XACM_RS08010	COG0077	Prephenate dehydratase
XACM_RS08010	COG1605	Chorismate mutase
XACM_RS08015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XACM_RS08030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XACM_RS08035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XACM_RS08040	COG0583	DNA-binding transcription factor activity
XACM_RS08060	COG2801	Transposase and inactivated derivatives
XACM_RS08065	COG2963	transposase activity
XACM_RS08070	COG2003	Belongs to the UPF0758 family
XACM_RS08105	COG2801	Transposase and inactivated derivatives
XACM_RS08110	COG2963	transposase activity
XACM_RS08140	COG0758	DNA mediated transformation
XACM_RS08220	COG2814	Major facilitator Superfamily
XACM_RS08245	COG2963	transposase activity
XACM_RS08250	COG2801	Transposase and inactivated derivatives
XACM_RS08290	COG0840	transmembrane signaling receptor activity
XACM_RS08325	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XACM_RS08330	COG0784	Response regulator, receiver
XACM_RS08330	COG4191	Histidine kinase
XACM_RS08345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XACM_RS08355	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XACM_RS08365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XACM_RS08380	COG1595	DNA-templated transcription, initiation
XACM_RS08435	COG2244	polysaccharide biosynthetic process
XACM_RS08440	COG1216	Glycosyl transferase, family 2
XACM_RS08440	COG1442	glycosyl transferase family 8
XACM_RS08465	COG2264	protein methyltransferase activity
XACM_RS08475	COG0438	transferase activity, transferring glycosyl groups
XACM_RS08490	COG1136	(ABC) transporter
XACM_RS08495	COG1132	(ABC) transporter
XACM_RS08500	COG2271	Major facilitator Superfamily
XACM_RS08505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XACM_RS08520	COG1253	flavin adenine dinucleotide binding
XACM_RS08530	COG0306	phosphate transporter
XACM_RS08555	COG0504	CTP synthase activity
XACM_RS08570	COG0148	phosphopyruvate hydratase activity
XACM_RS08575	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XACM_RS08580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XACM_RS08585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XACM_RS08590	COG0585	pseudouridine synthase activity
XACM_RS08595	COG2840	Smr protein MutS2
XACM_RS08600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XACM_RS08605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XACM_RS08610	COG1238	metal cluster binding
XACM_RS08625	COG1534	Rna-binding protein
XACM_RS08630	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XACM_RS08640	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XACM_RS08645	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XACM_RS08655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XACM_RS08660	COG1546	Belongs to the CinA family
XACM_RS08670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XACM_RS08675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XACM_RS08685	COG2137	regulation of response to DNA damage stimulus
XACM_RS08690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XACM_RS08695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XACM_RS08710	COG1741	Belongs to the pirin family
XACM_RS08720	COG0583	DNA-binding transcription factor activity
XACM_RS08745	COG0351	phosphomethylpyrimidine kinase
XACM_RS08760	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XACM_RS08765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XACM_RS08780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XACM_RS08790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XACM_RS08795	COG3734	2-keto-3-deoxy-galactonokinase
XACM_RS08805	COG4948	Mandelate Racemase Muconate Lactonizing
XACM_RS08810	COG0800	Aldolase
XACM_RS08850	COG1501	Belongs to the glycosyl hydrolase 31 family
XACM_RS08860	COG1070	Carbohydrate kinase
XACM_RS08865	COG2115	Belongs to the xylose isomerase family
XACM_RS08870	COG0477	Major facilitator Superfamily
XACM_RS08885	COG0860	N-Acetylmuramoyl-L-alanine amidase
XACM_RS08890	COG1469	GTP cyclohydrolase I activity
XACM_RS08910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XACM_RS08915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XACM_RS08920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XACM_RS08925	COG0166	Belongs to the GPI family
XACM_RS08945	COG1472	Belongs to the glycosyl hydrolase 3 family
XACM_RS08955	COG2203	Gaf domain
XACM_RS08955	COG3706	GGDEF domain
XACM_RS08955	COG4251	negative regulation of phosphorylation
XACM_RS08955	COG5001	Diguanylate cyclase
XACM_RS08965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XACM_RS08970	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XACM_RS08980	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XACM_RS08985	COG0671	phosphoesterase, PA-phosphatase related
XACM_RS08995	COG1794	racemase activity, acting on amino acids and derivatives
XACM_RS09005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XACM_RS09010	COG0167	dihydroorotate dehydrogenase activity
XACM_RS09025	COG1012	belongs to the aldehyde dehydrogenase family
XACM_RS09055	COG3210	domain, Protein
XACM_RS09055	COG3210	domain, Protein
XACM_RS09055	COG3210	domain, Protein
XACM_RS09065	COG2801	Transposase and inactivated derivatives
XACM_RS09070	COG2963	transposase activity
XACM_RS09080	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
XACM_RS09085	COG0460	homoserine dehydrogenase
XACM_RS09085	COG0527	aspartate kinase activity
XACM_RS09100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
XACM_RS09110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XACM_RS09115	COG0124	histidyl-tRNA synthetase
XACM_RS09125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XACM_RS09130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XACM_RS09135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XACM_RS09140	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XACM_RS09140	COG0131	Imidazoleglycerol-phosphate dehydratase
XACM_RS09145	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XACM_RS09150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XACM_RS09155	COG0107	imidazoleglycerol-phosphate synthase activity
XACM_RS09160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XACM_RS09160	COG0140	phosphoribosyl-ATP diphosphatase activity
XACM_RS09175	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XACM_RS09180	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XACM_RS09185	COG0235	Class ii aldolase
XACM_RS09190	COG0531	amino acid
XACM_RS09195	COG0531	amino acid
XACM_RS09205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XACM_RS09210	COG0277	FAD linked oxidase domain protein
XACM_RS09230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XACM_RS09275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XACM_RS09280	COG2258	MOSC domain
XACM_RS09285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XACM_RS09290	COG0505	Belongs to the CarA family
XACM_RS09300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XACM_RS09305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XACM_RS09315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XACM_RS09325	COG3279	Response regulator of the LytR AlgR family
XACM_RS09330	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XACM_RS09335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XACM_RS09345	COG2198	Histidine kinase
XACM_RS09345	COG0784	Response regulator, receiver
XACM_RS09345	COG2205	protein histidine kinase activity
XACM_RS09350	COG2198	Histidine kinase
XACM_RS09350	COG0784	Response regulator, receiver
XACM_RS09350	COG2205	protein histidine kinase activity
XACM_RS09355	COG1024	Enoyl-CoA hydratase
XACM_RS09360	COG0318	PFAM AMP-dependent synthetase and ligase
XACM_RS09395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XACM_RS09405	COG2201	protein-glutamate methylesterase activity
XACM_RS09410	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XACM_RS09420	COG0840	transmembrane signaling receptor activity
XACM_RS09430	COG0835	chemotaxis
XACM_RS09445	COG0840	transmembrane signaling receptor activity
XACM_RS09450	COG0840	transmembrane signaling receptor activity
XACM_RS09455	COG0840	transmembrane signaling receptor activity
XACM_RS09460	COG0840	transmembrane signaling receptor activity
XACM_RS09475	COG0840	transmembrane signaling receptor activity
XACM_RS09480	COG0840	transmembrane signaling receptor activity
XACM_RS09485	COG0840	transmembrane signaling receptor activity
XACM_RS09495	COG0840	transmembrane signaling receptor activity
XACM_RS09510	COG0840	transmembrane signaling receptor activity
XACM_RS09515	COG0840	transmembrane signaling receptor activity
XACM_RS09525	COG0745	RESPONSE REGULATOR receiver
XACM_RS09535	COG0835	chemotaxis
XACM_RS09545	COG1360	Flagellar Motor Protein
XACM_RS09550	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XACM_RS09595	COG0784	Response regulator, receiver
XACM_RS09595	COG2198	Histidine kinase
XACM_RS09595	COG0643	Histidine kinase
XACM_RS09625	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XACM_RS09650	COG1684	flagellar biosynthetic protein fliR
XACM_RS09670	COG3190	flagellar
XACM_RS09720	COG1677	Flagellar hook-basal body complex protein FliE
XACM_RS09730	COG0275	rRNA processing
XACM_RS09735	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XACM_RS09770	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS09775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XACM_RS09795	COG2201	protein-glutamate methylesterase activity
XACM_RS09825	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XACM_RS09830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XACM_RS09835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XACM_RS09845	COG1705	Flagellar rod assembly protein muramidase FlgJ
XACM_RS09845	COG3951	Flagellar rod assembly protein muramidase FlgJ
XACM_RS09850	COG1706	bacterial-type flagellum-dependent cell motility
XACM_RS09855	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XACM_RS09865	COG4787	bacterial-type flagellum-dependent cell motility
XACM_RS09875	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XACM_RS09880	COG1558	bacterial-type flagellum-dependent cell motility
XACM_RS09890	COG0835	chemotaxis
XACM_RS09890	COG0784	Response regulator, receiver
XACM_RS09915	COG5002	protein histidine kinase activity
XACM_RS09950	COG2915	High frequency lysogenization protein hflD homolog
XACM_RS09955	COG0482	sulfurtransferase activity
XACM_RS09970	COG0542	response to heat
XACM_RS09980	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XACM_RS09995	COG0492	ferredoxin-NADP+ reductase activity
XACM_RS10000	COG1674	ftsk spoiiie
XACM_RS10010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XACM_RS10020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XACM_RS10025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XACM_RS10030	COG0183	Belongs to the thiolase family
XACM_RS10035	COG1250	3-hydroxyacyl-CoA dehydrogenase
XACM_RS10035	COG1024	Enoyl-CoA hydratase
XACM_RS10050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XACM_RS10070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XACM_RS10075	COG1160	GTP binding
XACM_RS10080	COG0303	'Molybdopterin
XACM_RS10085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XACM_RS10125	COG0708	Exodeoxyribonuclease III
XACM_RS10135	COG0303	'Molybdopterin
XACM_RS10140	COG0746	molybdenum cofactor guanylyltransferase activity
XACM_RS10165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XACM_RS10165	COG1648	precorrin-2 dehydrogenase activity
XACM_RS10175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XACM_RS10180	COG2223	nitrite transmembrane transporter activity
XACM_RS10185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XACM_RS10195	COG0243	molybdopterin cofactor binding
XACM_RS10210	COG3685	Protein conserved in bacteria
XACM_RS10225	COG5001	Diguanylate cyclase
XACM_RS10235	COG4566	intracellular signal transduction
XACM_RS10255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_RS10270	COG3275	phosphorelay sensor kinase activity
XACM_RS10275	COG3279	Response regulator of the LytR AlgR family
XACM_RS10420	COG0631	protein serine/threonine phosphatase activity
XACM_RS10425	COG0515	serine threonine protein kinase
XACM_RS10450	COG1858	cytochrome C peroxidase
XACM_RS10465	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XACM_RS10475	COG2963	transposase activity
XACM_RS10480	COG2801	Transposase and inactivated derivatives
XACM_RS10505	COG4644	lycopene metabolic process
XACM_RS10510	COG2951	lytic endotransglycosylase activity
XACM_RS10520	COG1914	H( )-stimulated, divalent metal cation uptake system
XACM_RS10535	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XACM_RS10540	COG0668	transmembrane transport
XACM_RS10550	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XACM_RS10565	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS10570	COG1183	phosphatidylcholine synthase activity
XACM_RS10580	COG3243	poly(R)-hydroxyalkanoic acid synthase
XACM_RS10595	COG0723	plastoquinol--plastocyanin reductase activity
XACM_RS10595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XACM_RS10605	COG2183	response to ionizing radiation
XACM_RS10610	COG0784	Response regulator, receiver
XACM_RS10610	COG2205	protein histidine kinase activity
XACM_RS10675	COG0800	Aldolase
XACM_RS10680	COG0129	dihydroxy-acid dehydratase activity
XACM_RS10685	COG0363	glucosamine-6-phosphate deaminase activity
XACM_RS10690	COG0837	glucose binding
XACM_RS10695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XACM_RS10705	COG0354	folic acid binding
XACM_RS10715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XACM_RS10730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XACM_RS10735	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XACM_RS10745	COG4591	ABC-type transport system involved in lipoprotein release permease component
XACM_RS10750	COG1136	(ABC) transporter
XACM_RS10765	COG0811	peptide transport
XACM_RS10775	COG1132	(ABC) transporter
XACM_RS10780	COG1663	tetraacyldisaccharide 4'-kinase activity
XACM_RS10785	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XACM_RS10790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XACM_RS10800	COG0322	excinuclease ABC activity
XACM_RS10805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XACM_RS10830	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XACM_RS10850	COG1054	Belongs to the UPF0176 family
XACM_RS10860	COG1530	ribonuclease E activity
XACM_RS10870	COG3064	Membrane
XACM_RS10875	COG0428	transporter
XACM_RS10885	COG2154	pterin-4-alpha-carbinolamine dehydratase
XACM_RS10890	COG0316	Belongs to the HesB IscA family
XACM_RS10890	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XACM_RS10905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_RS10910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XACM_RS10950	COG0363	glucosamine-6-phosphate deaminase activity
XACM_RS10965	COG1073	alpha beta
XACM_RS10965	COG2226	methyltransferase
XACM_RS10990	COG2197	response regulator
XACM_RS10995	COG4585	Histidine kinase
XACM_RS11000	COG2951	lytic endotransglycosylase activity
XACM_RS11005	COG4644	lycopene metabolic process
XACM_RS11035	COG2814	Major facilitator Superfamily
XACM_RS11050	COG1335	isochorismatase
XACM_RS11060	COG4585	Histidine kinase
XACM_RS11065	COG2197	response regulator
XACM_RS11080	COG0583	DNA-binding transcription factor activity
XACM_RS11105	COG0633	Ferredoxin
XACM_RS11115	COG0583	DNA-binding transcription factor activity
XACM_RS11120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XACM_RS11125	COG3002	Belongs to the UPF0753 family
XACM_RS11130	COG0667	Aldo Keto reductase
XACM_RS11135	COG0583	DNA-binding transcription factor activity
XACM_RS11145	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS11150	COG2818	Glycosylase
XACM_RS11255	COG0582	viral genome integration into host DNA
XACM_RS11260	COG0519	Catalyzes the synthesis of GMP from XMP
XACM_RS11260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XACM_RS11270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XACM_RS11280	COG0475	glutathione-regulated potassium exporter activity
XACM_RS11280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XACM_RS11285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XACM_RS11295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XACM_RS11300	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XACM_RS11310	COG0776	regulation of translation
XACM_RS11315	COG0539	negative regulation of cytoplasmic translation
XACM_RS11320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XACM_RS11335	COG2957	Belongs to the agmatine deiminase family
XACM_RS11340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XACM_RS11365	COG0395	ABC-type sugar transport system, permease component
XACM_RS11370	COG1175	transmembrane transport
XACM_RS11400	COG2350	Protein conserved in bacteria
XACM_RS11405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XACM_RS11410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XACM_RS11415	COG1187	pseudouridine synthase activity
XACM_RS11435	COG0436	Aminotransferase
XACM_RS11440	COG4133	protoheme IX ABC transporter activity
XACM_RS11460	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XACM_RS11465	COG1138	Cytochrome C-type biogenesis protein
XACM_RS11485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XACM_RS11490	COG1278	Cold shock
XACM_RS11495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XACM_RS11500	COG4988	ABC transporter
XACM_RS11510	COG1294	oxidase, subunit
XACM_RS11540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XACM_RS11545	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XACM_RS11555	COG0165	Argininosuccinate lyase
XACM_RS11560	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XACM_RS11570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XACM_RS11575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XACM_RS11585	COG0137	argininosuccinate synthase activity
XACM_RS11590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XACM_RS11600	COG0215	cysteine-tRNA ligase activity
XACM_RS11605	COG2166	iron-sulfur cluster assembly
XACM_RS11625	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XACM_RS11630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XACM_RS11655	COG4302	ethanolamine ammonia-lyase activity
XACM_RS11690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XACM_RS11695	COG0402	S-adenosylhomocysteine deaminase activity
XACM_RS11705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XACM_RS11710	COG1509	lysine 2,3-aminomutase activity
XACM_RS11715	COG5001	Diguanylate cyclase
XACM_RS11715	COG3300	MHYT domain
XACM_RS11730	COG0483	inositol monophosphate 1-phosphatase activity
XACM_RS11735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XACM_RS11750	COG0488	(ABC) transporter
XACM_RS11755	COG0513	Belongs to the DEAD box helicase family
XACM_RS11760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XACM_RS11765	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XACM_RS11775	COG0625	glutathione transferase activity
XACM_RS11785	COG4681	YaeQ
XACM_RS11790	COG2081	HI0933 family
XACM_RS11800	COG0501	Belongs to the peptidase M48B family
XACM_RS11805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XACM_RS11810	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS11830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XACM_RS11835	COG0860	N-Acetylmuramoyl-L-alanine amidase
XACM_RS11840	COG0802	atpase or kinase
XACM_RS11845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XACM_RS11845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XACM_RS11850	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XACM_RS11855	COG1570	exodeoxyribonuclease VII activity
XACM_RS11865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XACM_RS11905	COG0835	chemotaxis
XACM_RS11910	COG0840	transmembrane signaling receptor activity
XACM_RS11915	COG2094	Belongs to the DNA glycosylase MPG family
XACM_RS11920	COG1201	RNA secondary structure unwinding
XACM_RS11935	COG2969	positive regulation of protein catabolic process
XACM_RS11940	COG0625	glutathione transferase activity
XACM_RS11945	COG2857	Cytochrome c1
XACM_RS11950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XACM_RS11955	COG0723	plastoquinol--plastocyanin reductase activity
XACM_RS11960	COG0741	lytic transglycosylase activity
XACM_RS11975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XACM_RS11980	COG1702	phosphate starvation-inducible protein PhoH
XACM_RS11990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XACM_RS12000	COG4535	Mg2 and Co2 transporter CorC
XACM_RS12015	COG1012	belongs to the aldehyde dehydrogenase family
XACM_RS12025	COG1177	transmembrane transport
XACM_RS12030	COG1176	ABC-type spermidine putrescine transport system, permease component I
XACM_RS12035	COG3842	ATPase activity
XACM_RS12055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XACM_RS12070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XACM_RS12075	COG0174	glutamine synthetase
XACM_RS12080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XACM_RS12090	COG2703	oxygen carrier activity
XACM_RS12095	COG0477	Major facilitator Superfamily
XACM_RS12105	COG0243	molybdopterin cofactor binding
XACM_RS12110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XACM_RS12115	COG2223	nitrite transmembrane transporter activity
XACM_RS12120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XACM_RS12130	COG2733	membrane
XACM_RS12135	COG2205	protein histidine kinase activity
XACM_RS12135	COG5002	protein histidine kinase activity
XACM_RS12135	COG0784	Response regulator, receiver
XACM_RS12145	COG0477	Major facilitator Superfamily
XACM_RS12150	COG2902	Dehydrogenase
XACM_RS12160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_RS12165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XACM_RS12170	COG1609	Transcriptional regulator
XACM_RS12175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XACM_RS12175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XACM_RS12180	COG1105	Belongs to the carbohydrate kinase PfkB family
XACM_RS12185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XACM_RS12185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XACM_RS12210	COG2801	Transposase and inactivated derivatives
XACM_RS12215	COG2963	transposase activity
XACM_RS12220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XACM_RS12230	COG1862	Preprotein translocase
XACM_RS12235	COG0343	queuine tRNA-ribosyltransferase activity
XACM_RS12240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XACM_RS12280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XACM_RS12285	COG3291	Pkd domain containing protein
XACM_RS12295	COG0405	Gamma-glutamyltransferase
XACM_RS12300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XACM_RS12315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XACM_RS12320	COG0742	ribosomal rna small subunit methyltransferase
XACM_RS12325	COG0326	Molecular chaperone. Has ATPase activity
XACM_RS12390	COG0531	amino acid
XACM_RS12405	COG0006	proline dipeptidase activity
XACM_RS12415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XACM_RS12430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XACM_RS12435	COG3938	Belongs to the proline racemase family
XACM_RS12445	COG0552	protein localization to endoplasmic reticulum
XACM_RS12450	COG1194	a g-specific adenine glycosylase
XACM_RS12455	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XACM_RS12465	COG0784	Response regulator, receiver
XACM_RS12465	COG4191	Histidine kinase
XACM_RS12480	COG0322	excinuclease ABC activity
XACM_RS12495	COG3040	lipid binding
XACM_RS12505	COG1960	acyl-CoA dehydrogenase activity
XACM_RS12515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XACM_RS12535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XACM_RS12540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XACM_RS12545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XACM_RS12570	COG0438	transferase activity, transferring glycosyl groups
XACM_RS12580	COG0438	transferase activity, transferring glycosyl groups
XACM_RS12585	COG0438	transferase activity, transferring glycosyl groups
XACM_RS12635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XACM_RS12635	COG0072	phenylalanine-tRNA ligase activity
XACM_RS12640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XACM_RS12655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XACM_RS12660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XACM_RS12685	COG1082	Xylose isomerase domain protein TIM barrel
XACM_RS12695	COG0366	Alpha amylase catalytic
XACM_RS12745	COG3505	Type IV secretory pathway VirD4
XACM_RS12760	COG0556	nucleotide-excision repair
XACM_RS12795	COG3275	phosphorelay sensor kinase activity
XACM_RS12800	COG1611	Belongs to the LOG family
XACM_RS12810	COG2095	MarC family integral membrane protein
XACM_RS12820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XACM_RS12855	COG1185	polyribonucleotide nucleotidyltransferase activity
XACM_RS12860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XACM_RS12865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XACM_RS12870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XACM_RS12875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XACM_RS12880	COG0195	Participates in both transcription termination and antitermination
XACM_RS12885	COG0779	Required for maturation of 30S ribosomal subunits
XACM_RS12895	COG1007	ATP synthesis coupled electron transport
XACM_RS12920	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XACM_RS12925	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XACM_RS12930	COG1034	ATP synthesis coupled electron transport
XACM_RS12935	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XACM_RS12940	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XACM_RS12945	COG0649	NAD binding
XACM_RS12950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XACM_RS12955	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XACM_RS12960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XACM_RS12975	COG0149	triose-phosphate isomerase activity
XACM_RS12980	COG4221	oxidoreductase activity
XACM_RS13015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XACM_RS13020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XACM_RS13025	COG0159	tryptophan synthase activity
XACM_RS13035	COG0133	tryptophan synthase activity
XACM_RS13045	COG0135	phosphoribosylanthranilate isomerase activity
XACM_RS13050	COG0101	tRNA pseudouridine synthase activity
XACM_RS13070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XACM_RS13075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XACM_RS13080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XACM_RS13085	COG2890	protein-(glutamine-N5) methyltransferase activity
XACM_RS13095	COG0688	phosphatidylethanolamine metabolic process
XACM_RS13105	COG0433	COG0433 Predicted ATPase
XACM_RS13110	COG0494	nUDIX hydrolase
XACM_RS13125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XACM_RS13130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XACM_RS13155	COG0717	Belongs to the dCTP deaminase family
XACM_RS13160	COG0489	protein tyrosine kinase activity
XACM_RS13180	COG3590	peptidase
XACM_RS13185	COG3590	peptidase
XACM_RS13210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XACM_RS13215	COG2311	Membrane
XACM_RS13220	COG1047	Peptidyl-prolyl cis-trans
XACM_RS13225	COG0791	NLP P60 protein
XACM_RS13230	COG0791	NLP P60 protein
XACM_RS13245	COG1301	dicarboxylic acid transport
XACM_RS13250	COG1785	Belongs to the alkaline phosphatase family
XACM_RS13260	COG0037	tRNA processing
XACM_RS13265	COG1722	exodeoxyribonuclease VII activity
XACM_RS13270	COG0142	geranyltranstransferase activity
XACM_RS13275	COG4104	PAAR repeat-containing protein
XACM_RS13285	COG0312	modulator of DNA gyrase
XACM_RS13290	COG3028	Belongs to the UPF0307 family
XACM_RS13295	COG0312	modulator of DNA gyrase
XACM_RS13305	COG3164	Protein of unknown function
XACM_RS13315	COG0424	maF-like protein
XACM_RS13320	COG2968	Membrane
XACM_RS13335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XACM_RS13350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XACM_RS13365	COG0495	leucyl-tRNA aminoacylation
XACM_RS13375	COG3118	belongs to the thioredoxin family
XACM_RS13405	COG2155	Conserved Protein
XACM_RS13460	COG1132	(ABC) transporter
XACM_RS13485	COG1538	Outer membrane efflux protein
XACM_RS13490	COG0745	RESPONSE REGULATOR receiver
XACM_RS13495	COG5000	phosphorelay sensor kinase activity
XACM_RS13495	COG5002	protein histidine kinase activity
XACM_RS13500	COG0475	glutathione-regulated potassium exporter activity
XACM_RS13510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XACM_RS13535	COG1187	pseudouridine synthase activity
XACM_RS13540	COG5002	protein histidine kinase activity
XACM_RS13540	COG5001	Diguanylate cyclase
XACM_RS13650	COG0667	Aldo Keto reductase
XACM_RS13655	COG2814	Major facilitator Superfamily
XACM_RS13660	COG0583	DNA-binding transcription factor activity
XACM_RS13670	COG2207	Transcriptional regulator
XACM_RS13685	COG1309	transcriptional regulator
XACM_RS13695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XACM_RS13710	COG0735	belongs to the Fur family
XACM_RS13715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XACM_RS13740	COG4452	Inner membrane protein CreD
XACM_RS13755	COG2205	protein histidine kinase activity
XACM_RS13760	COG0745	RESPONSE REGULATOR receiver
XACM_RS13765	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XACM_RS13775	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XACM_RS13785	COG0643	Histidine kinase
XACM_RS13785	COG2198	Histidine kinase
XACM_RS13790	COG0840	transmembrane signaling receptor activity
XACM_RS13795	COG0835	chemotaxis
XACM_RS13800	COG2199	diguanylate cyclase activity
XACM_RS13800	COG2200	EAL domain
XACM_RS13800	COG2202	Pas domain
XACM_RS13805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XACM_RS13810	COG2201	protein-glutamate methylesterase activity
XACM_RS13815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XACM_RS13820	COG3590	peptidase
XACM_RS13830	COG0588	phosphoglycerate mutase activity
XACM_RS13835	COG1515	deoxyribonuclease V activity
XACM_RS13850	COG1741	Belongs to the pirin family
XACM_RS13865	COG1741	Belongs to the pirin family
XACM_RS13870	COG1966	Carbon starvation protein
XACM_RS13875	COG2879	small protein
XACM_RS13920	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XACM_RS13925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XACM_RS13930	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XACM_RS13935	COG2080	2 iron, 2 sulfur cluster binding
XACM_RS13940	COG0604	alcohol dehydrogenase
XACM_RS13940	COG3321	synthase
XACM_RS13940	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS13945	COG3706	GGDEF domain
XACM_RS13945	COG4251	negative regulation of phosphorylation
XACM_RS13945	COG5001	Diguanylate cyclase
XACM_RS13945	COG2203	Gaf domain
XACM_RS13950	COG0629	single-stranded DNA binding
XACM_RS13955	COG0142	geranyltranstransferase activity
XACM_RS13965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XACM_RS13980	COG0527	aspartate kinase activity
XACM_RS13985	COG0384	phenazine biosynthesis protein PhzF
XACM_RS13990	COG0384	phenazine biosynthesis protein PhzF
XACM_RS14000	COG1764	response to oxidative stress
XACM_RS14005	COG0540	Belongs to the ATCase OTCase family
XACM_RS14010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XACM_RS14015	COG1678	Uncharacterized ACR, COG1678
XACM_RS14020	COG0519	Catalyzes the synthesis of GMP from XMP
XACM_RS14050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XACM_RS14065	COG0739	heme binding
XACM_RS14085	COG0693	protein deglycase activity
XACM_RS14095	COG1959	2 iron, 2 sulfur cluster binding
XACM_RS14100	COG0719	Fe-S assembly protein
XACM_RS14105	COG0396	ATPase activity
XACM_RS14110	COG0719	Fe-S assembly protein
XACM_RS14115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XACM_RS14120	COG0456	acetyltransferase
XACM_RS14125	COG2146	nitrite reductase [NAD(P)H] activity
XACM_RS14135	COG4774	siderophore transport
XACM_RS14140	COG3128	pkhd-type hydroxylase
XACM_RS14165	COG1477	protein flavinylation
XACM_RS14170	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XACM_RS14185	COG1555	photosystem II stabilization
XACM_RS14205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XACM_RS14215	COG0628	permease
XACM_RS14225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XACM_RS14235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XACM_RS14255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XACM_RS14260	COG0271	Belongs to the BolA IbaG family
XACM_RS14270	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XACM_RS14280	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XACM_RS14285	COG1137	ATPase activity
XACM_RS14300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XACM_RS14305	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XACM_RS14310	COG1660	Displays ATPase and GTPase activities
XACM_RS14320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XACM_RS14325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XACM_RS14330	COG2239	Acts as a magnesium transporter
XACM_RS14340	COG1294	oxidase, subunit
XACM_RS14345	COG1271	oxidase subunit
XACM_RS14355	COG1113	amino acid transport
XACM_RS14380	COG2197	response regulator
XACM_RS14385	COG0531	amino acid
XACM_RS14450	COG2814	Major facilitator Superfamily
XACM_RS14455	COG0754	glutathionylspermidine amidase activity
XACM_RS14480	COG1842	Phage shock protein A
XACM_RS14490	COG0259	pyridoxamine-phosphate oxidase activity
XACM_RS14495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XACM_RS14500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XACM_RS14510	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XACM_RS14515	COG2814	Major facilitator Superfamily
XACM_RS14540	COG0784	Response regulator, receiver
XACM_RS14540	COG2205	protein histidine kinase activity
XACM_RS14540	COG2198	Histidine kinase
XACM_RS14545	COG2353	YceI-like domain
XACM_RS14565	COG1760	l-serine dehydratase
XACM_RS14575	COG0460	homoserine dehydrogenase
XACM_RS14575	COG0527	aspartate kinase activity
XACM_RS14580	COG0626	cystathionine gamma-synthase activity
XACM_RS14585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XACM_RS14590	COG0739	heme binding
XACM_RS14595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XACM_RS14600	COG1272	protein, Hemolysin III
XACM_RS14605	COG2982	Protein involved in outer membrane biogenesis
XACM_RS14610	COG0516	GMP reductase activity
XACM_RS14610	COG0517	IMP dehydrogenase activity
XACM_RS14615	COG0463	Glycosyl transferase, family 2
XACM_RS14620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XACM_RS14625	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XACM_RS14640	COG1309	transcriptional regulator
XACM_RS14650	COG1960	acyl-CoA dehydrogenase activity
XACM_RS14675	COG0509	glycine decarboxylation via glycine cleavage system
XACM_RS14680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XACM_RS14690	COG0330	HflC and HflK could
XACM_RS14695	COG1742	UPF0060 membrane protein
XACM_RS14700	COG3956	TIGRFAM MazG family protein
XACM_RS14710	COG0494	nUDIX hydrolase
XACM_RS14720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XACM_RS14725	COG0837	glucose binding
XACM_RS14740	COG3858	chitin binding
XACM_RS14740	COG1388	LysM domain
XACM_RS14745	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XACM_RS14755	COG1472	Belongs to the glycosyl hydrolase 3 family
XACM_RS14765	COG3537	Alpha-1,2-mannosidase
XACM_RS14800	COG3142	Participates in the control of copper homeostasis
XACM_RS14805	COG1446	asparaginase
XACM_RS14810	COG2304	oxidoreductase activity
XACM_RS14815	COG1595	DNA-templated transcription, initiation
XACM_RS14845	COG0643	Histidine kinase
XACM_RS14845	COG2198	Histidine kinase
XACM_RS14845	COG0784	Response regulator, receiver
XACM_RS14850	COG0840	transmembrane signaling receptor activity
XACM_RS14855	COG0835	chemotaxis
XACM_RS14870	COG0189	ligase activity
XACM_RS14880	COG1397	ADP-ribosylglycohydrolase
XACM_RS14890	COG1397	ADP-ribosylglycohydrolase
XACM_RS14895	COG1214	PFAM Peptidase M22, glycoprotease
XACM_RS14900	COG1199	ATP-dependent helicase activity
XACM_RS14910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XACM_RS14915	COG1215	transferase activity, transferring glycosyl groups
XACM_RS14925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XACM_RS14930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XACM_RS14935	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XACM_RS14940	COG0535	radical SAM domain protein
XACM_RS14945	COG0535	radical SAM domain protein
XACM_RS14960	COG0837	glucose binding
XACM_RS14970	COG1643	Atp-dependent helicase
XACM_RS14975	COG0783	Belongs to the Dps family
XACM_RS14980	COG0514	ATP-dependent DNA helicase (RecQ)
XACM_RS15010	COG1187	pseudouridine synthase activity
XACM_RS15020	COG0840	transmembrane signaling receptor activity
XACM_RS15040	COG3920	Histidine kinase
XACM_RS15045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XACM_RS15055	COG0602	queuosine metabolic process
XACM_RS15065	COG2885	chlorophyll binding
XACM_RS15070	COG0823	Involved in the tonB-independent uptake of proteins
XACM_RS15080	COG0848	biopolymer transport protein
XACM_RS15090	COG0824	Thioesterase
XACM_RS15095	COG2255	four-way junction helicase activity
XACM_RS15105	COG3158	transport of potassium into the cell
XACM_RS15110	COG0632	four-way junction helicase activity
XACM_RS15115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XACM_RS15120	COG0217	transcriptional regulatory protein
XACM_RS15135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XACM_RS15150	COG0477	Major facilitator Superfamily
XACM_RS15165	COG0657	acetylesterase activity
XACM_RS15165	COG2755	lipolytic protein G-D-S-L family
XACM_RS15185	COG0488	(ABC) transporter
XACM_RS15215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XACM_RS15215	COG4651	solute:proton antiporter activity
XACM_RS15225	COG4772	TonB-dependent receptor
XACM_RS15235	COG4264	IucA IucC family
XACM_RS15240	COG2814	Major facilitator Superfamily
XACM_RS15250	COG0019	diaminopimelate decarboxylase activity
XACM_RS15270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XACM_RS15280	COG1492	cobalamin metabolic process
XACM_RS15310	COG4206	TonB-dependent receptor
XACM_RS15315	COG0542	response to heat
XACM_RS15360	COG1877	trehalose-phosphatase activity
XACM_RS15365	COG3387	PFAM Glycoside hydrolase 15-related
XACM_RS15380	COG0840	transmembrane signaling receptor activity
XACM_RS15385	COG3011	Protein conserved in bacteria
XACM_RS15400	COG0564	pseudouridine synthase activity
XACM_RS15405	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XACM_RS15415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XACM_RS15415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XACM_RS15430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XACM_RS15435	COG0045	succinate-CoA ligase (ADP-forming) activity
XACM_RS15475	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XACM_RS15480	COG0237	dephospho-CoA kinase activity
XACM_RS15490	COG0745	RESPONSE REGULATOR receiver
XACM_RS15500	COG0189	ligase activity
XACM_RS15570	COG0210	DNA helicase
XACM_RS15675	COG2963	transposase activity
XACM_RS15680	COG2801	Transposase and inactivated derivatives
XACM_RS15720	COG2022	thiamine diphosphate biosynthetic process
XACM_RS15725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XACM_RS15730	COG3273	potassium ion transport
XACM_RS15730	COG0471	metal ion transport
XACM_RS15750	COG1970	mechanosensitive ion channel activity
XACM_RS15765	COG1609	Transcriptional regulator
XACM_RS15775	COG3250	beta-galactosidase activity
XACM_RS15780	COG4948	Mandelate Racemase Muconate Lactonizing
XACM_RS15795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XACM_RS15810	COG0308	aminopeptidase N
XACM_RS15815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XACM_RS15825	COG0529	Catalyzes the synthesis of activated sulfate
XACM_RS15825	COG2895	sulfate adenylyltransferase (ATP) activity
XACM_RS15830	COG0175	sulfate reduction
XACM_RS15835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XACM_RS15840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XACM_RS15845	COG0175	sulfate reduction
XACM_RS15865	COG0784	Response regulator, receiver
XACM_RS15865	COG2198	Histidine kinase
XACM_RS15865	COG2205	protein histidine kinase activity
XACM_RS15885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XACM_RS15885	COG1648	precorrin-2 dehydrogenase activity
XACM_RS15900	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XACM_RS15905	COG3588	fructose-bisphosphate aldolase
XACM_RS15910	COG0469	pyruvate kinase activity
XACM_RS15920	COG0126	phosphoglycerate kinase activity
XACM_RS15940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XACM_RS15950	COG3047	cAMP biosynthetic process
XACM_RS15955	COG3047	cAMP biosynthetic process
XACM_RS15965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XACM_RS15965	COG3453	Protein conserved in bacteria
XACM_RS15970	COG0725	ABC transporter, periplasmic molybdate-binding protein
XACM_RS15975	COG4149	molybdate abc transporter
XACM_RS15980	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XACM_RS16015	COG1376	ErfK ybiS ycfS ynhG family protein
XACM_RS16020	COG0739	heme binding
XACM_RS16025	COG4773	Receptor
XACM_RS16030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XACM_RS16035	COG1301	dicarboxylic acid transport
XACM_RS16045	COG2304	oxidoreductase activity
XACM_RS16065	COG0714	Associated with various cellular activities
XACM_RS16095	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XACM_RS16115	COG1957	nucleoside hydrolase
XACM_RS16120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XACM_RS16130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XACM_RS16140	COG0194	GDP metabolic process
XACM_RS16145	COG1561	YicC-like family, N-terminal region
XACM_RS16150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XACM_RS16160	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XACM_RS16165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XACM_RS16180	COG0006	proline dipeptidase activity
XACM_RS16190	COG0006	proline dipeptidase activity
XACM_RS16195	COG3079	Belongs to the UPF0149 family
XACM_RS16210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XACM_RS16220	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XACM_RS16230	COG2912	Transglutaminase-like superfamily
XACM_RS16235	COG1773	rubredoxin
XACM_RS16240	COG0352	thiamine-phosphate diphosphorylase activity
XACM_RS16250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XACM_RS16260	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XACM_RS16265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XACM_RS16295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XACM_RS16300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XACM_RS16305	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS16315	COG0671	phosphoesterase, PA-phosphatase related
XACM_RS16320	COG3781	membrane
XACM_RS16330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XACM_RS16335	COG0563	adenylate kinase activity
XACM_RS16350	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XACM_RS16360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XACM_RS16380	COG3710	Transcriptional regulator
XACM_RS16385	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XACM_RS16395	COG0840	transmembrane signaling receptor activity
XACM_RS16405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XACM_RS16425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XACM_RS16430	COG0473	3-isopropylmalate dehydrogenase activity
XACM_RS16435	COG0066	3-isopropylmalate dehydratase activity
XACM_RS16440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XACM_RS16460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XACM_RS16465	COG1538	Outer membrane efflux protein
XACM_RS16470	COG1519	Transferase
XACM_RS16475	COG1560	Kdo2-lipid A biosynthetic process
XACM_RS16500	COG0280	phosphate acetyltransferase
XACM_RS16500	COG0281	malic enzyme
XACM_RS16505	COG1301	dicarboxylic acid transport
XACM_RS16530	COG0583	DNA-binding transcription factor activity
XACM_RS16540	COG0667	Aldo Keto reductase
XACM_RS16555	COG2197	response regulator
XACM_RS16565	COG0642	Histidine kinase
XACM_RS16580	COG2851	Citrate transporter
XACM_RS16585	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS16590	COG1609	Transcriptional regulator
XACM_RS16595	COG2211	Major facilitator Superfamily
XACM_RS16620	COG1162	GTPase activity
XACM_RS16650	COG0436	Aminotransferase
XACM_RS16665	COG0726	polysaccharide deacetylase
XACM_RS16670	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XACM_RS16685	COG3964	amidohydrolase
XACM_RS16690	COG0402	S-adenosylhomocysteine deaminase activity
XACM_RS16710	COG1307	EDD domain protein, DegV family
XACM_RS16715	COG0242	peptide deformylase activity
XACM_RS16740	COG0457	Tetratricopeptide repeat
XACM_RS16745	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XACM_RS16750	COG1215	transferase activity, transferring glycosyl groups
XACM_RS16755	COG1215	transferase activity, transferring glycosyl groups
XACM_RS16770	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XACM_RS16815	COG2188	Transcriptional regulator
XACM_RS16825	COG1450	Type ii and iii secretion system protein
XACM_RS16840	COG3166	PFAM Fimbrial assembly family protein
XACM_RS16845	COG3156	type II secretion system protein K
XACM_RS16850	COG4795	General secretion pathway protein
XACM_RS16855	COG2165	general secretion pathway protein
XACM_RS16860	COG4970	Tfp pilus assembly protein FimT
XACM_RS16865	COG2165	general secretion pathway protein
XACM_RS16870	COG1459	type II secretion system
XACM_RS16875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XACM_RS16880	COG1404	Belongs to the peptidase S8 family
XACM_RS16885	COG5295	Hep Hag repeat protein
XACM_RS16890	COG1404	Belongs to the peptidase S8 family
XACM_RS16895	COG5295	Hep Hag repeat protein
XACM_RS16905	COG0047	phosphoribosylformylglycinamidine synthase activity
XACM_RS16905	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XACM_RS16910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XACM_RS16915	COG4974	Belongs to the 'phage' integrase family
XACM_RS16930	COG0795	lipopolysaccharide-transporting ATPase activity
XACM_RS16940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XACM_RS16955	COG0525	valine-tRNA ligase activity
XACM_RS16990	COG1183	phosphatidylcholine synthase activity
XACM_RS17000	COG0442	prolyl-tRNA aminoacylation
XACM_RS17015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XACM_RS17020	COG1127	ABC transporter
XACM_RS17025	COG3218	ABC-type transport auxiliary lipoprotein component
XACM_RS17025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XACM_RS17055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XACM_RS17060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XACM_RS17065	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XACM_RS17065	COG0662	Cupin 2, conserved barrel domain protein
XACM_RS17095	COG2086	electron transfer activity
XACM_RS17110	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XACM_RS17110	COG0546	phosphoglycolate phosphatase activity
XACM_RS17115	COG0277	FAD linked oxidase domain protein
XACM_RS17125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XACM_RS17145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XACM_RS17150	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XACM_RS17170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XACM_RS17200	COG0626	cystathionine gamma-synthase activity
XACM_RS17230	COG0625	glutathione transferase activity
XACM_RS17240	COG0513	Belongs to the DEAD box helicase family
XACM_RS17245	COG0720	synthase
XACM_RS17255	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XACM_RS17265	COG1956	GAF domain-containing protein
XACM_RS17280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XACM_RS17285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XACM_RS17300	COG0339	signal peptide processing
XACM_RS17350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XACM_RS17355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_RS17360	COG1136	(ABC) transporter
XACM_RS17365	COG0577	efflux transmembrane transporter activity
XACM_RS17370	COG1136	(ABC) transporter
XACM_RS17370	COG0577	efflux transmembrane transporter activity
XACM_RS17390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XACM_RS17405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XACM_RS17410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XACM_RS17415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XACM_RS17420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XACM_RS17425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XACM_RS17430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XACM_RS17440	COG0356	it plays a direct role in the translocation of protons across the membrane
XACM_RS17460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XACM_RS17470	COG0508	dehydrogenase complex catalyzes the overall conversion of
XACM_RS17510	COG2011	ABC-type metal ion transport system permease component
XACM_RS17515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XACM_RS17520	COG0697	spore germination
XACM_RS17525	COG1666	GTP binding
XACM_RS17535	COG0784	Response regulator, receiver
XACM_RS17535	COG5002	protein histidine kinase activity
XACM_RS17535	COG2198	Histidine kinase
XACM_RS17560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XACM_RS17565	COG1187	pseudouridine synthase activity
XACM_RS17570	COG2813	Specifically methylates the guanine in position
XACM_RS17590	COG2205	protein histidine kinase activity
XACM_RS17590	COG2202	Pas domain
XACM_RS17610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XACM_RS17615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XACM_RS17670	COG0842	Transport permease protein
XACM_RS17675	COG1131	(ABC) transporter
XACM_RS17680	COG0025	NhaP-type Na H and K H
XACM_RS17685	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XACM_RS17690	COG1573	uracil-dna glycosylase
XACM_RS17700	COG3384	dioxygenase
XACM_RS17710	COG0583	DNA-binding transcription factor activity
XACM_RS17720	COG0667	Aldo Keto reductase
XACM_RS17730	COG3590	peptidase
XACM_RS17745	COG0531	amino acid
XACM_RS17760	COG2972	Histidine kinase
XACM_RS17775	COG3685	Protein conserved in bacteria
XACM_RS17780	COG3546	catalase activity
XACM_RS17815	COG2204	response regulator
XACM_RS17825	COG1271	oxidase subunit
XACM_RS17830	COG1294	oxidase, subunit
XACM_RS17845	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS17850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XACM_RS17870	COG1132	(ABC) transporter
XACM_RS17885	COG1063	alcohol dehydrogenase
XACM_RS17960	COG0251	oxidation-reduction process
XACM_RS17975	COG0583	DNA-binding transcription factor activity
XACM_RS17980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XACM_RS18010	COG0659	secondary active sulfate transmembrane transporter activity
XACM_RS18015	COG0038	chloride channel
XACM_RS18025	COG0024	Methionine aminopeptidase
XACM_RS18040	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS18055	COG2801	Transposase and inactivated derivatives
XACM_RS18060	COG2963	transposase activity
XACM_RS18135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XACM_RS18140	COG1490	D-aminoacyl-tRNA deacylase activity
XACM_RS18145	COG1560	Kdo2-lipid A biosynthetic process
XACM_RS18195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XACM_RS18195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XACM_RS18200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XACM_RS18205	COG0242	peptide deformylase activity
XACM_RS18210	COG1652	LysM domain
XACM_RS18215	COG0758	DNA mediated transformation
XACM_RS18235	COG1754	DNA topoisomerase type I activity
XACM_RS18235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XACM_RS18240	COG0009	L-threonylcarbamoyladenylate synthase
XACM_RS18255	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS18265	COG0616	signal peptide processing
XACM_RS18270	COG0534	Mate efflux family protein
XACM_RS18290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XACM_RS18310	COG1252	NADH dehydrogenase
XACM_RS18315	COG2860	membrane
XACM_RS18320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XACM_RS18325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XACM_RS18330	COG2201	protein-glutamate methylesterase activity
XACM_RS18335	COG2177	Part of the ABC transporter FtsEX involved in
XACM_RS18340	COG2884	Cell division ATP-binding protein ftsE
XACM_RS18350	COG3118	belongs to the thioredoxin family
XACM_RS18355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XACM_RS18365	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XACM_RS18370	COG0583	DNA-binding transcription factor activity
XACM_RS18390	COG1652	LysM domain
XACM_RS18395	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XACM_RS18395	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XACM_RS18400	COG1473	amidohydrolase
XACM_RS18405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_RS18410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XACM_RS18420	COG5383	Protein conserved in bacteria
XACM_RS18460	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XACM_RS18465	COG3023	N-Acetylmuramoyl-L-alanine amidase
XACM_RS18475	COG4948	Mandelate Racemase Muconate Lactonizing
XACM_RS18485	COG0531	amino acid
XACM_RS18500	COG4682	membrane
XACM_RS18505	COG2133	pyrroloquinoline quinone binding
XACM_RS18515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XACM_RS18520	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XACM_RS18530	COG1610	YqeY-like protein
XACM_RS18540	COG1295	ribonuclease BN
XACM_RS18545	COG0358	DNA primase activity
XACM_RS18560	COG0109	protoheme IX farnesyltransferase activity
XACM_RS18590	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XACM_RS18605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XACM_RS18645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XACM_RS18650	COG0739	heme binding
XACM_RS18655	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XACM_RS18665	COG2223	nitrite transmembrane transporter activity
XACM_RS18670	COG0708	Exodeoxyribonuclease III
XACM_RS18675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XACM_RS18685	COG1192	Involved in chromosome partitioning
XACM_RS18690	COG1475	DNA binding
XACM_RS18705	COG0463	Glycosyl transferase, family 2
XACM_RS18725	COG0756	dUTP diphosphatase activity
XACM_RS18730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XACM_RS18735	COG2003	Belongs to the UPF0758 family
XACM_RS18740	COG0018	arginyl-trna synthetase
XACM_RS18755	COG4221	oxidoreductase activity
XACM_RS18765	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XACM_RS18765	COG2755	lipolytic protein G-D-S-L family
XACM_RS18775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XACM_RS18785	COG1166	arginine decarboxylase activity
XACM_RS18790	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XACM_RS18815	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XACM_RS18815	COG3291	Pkd domain containing protein
XACM_RS18830	COG0606	chelatase, subunit chli
XACM_RS18845	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XACM_RS18885	COG1690	Belongs to the RtcB family
XACM_RS18925	COG1090	epimerase
XACM_RS18935	COG0642	Histidine kinase
XACM_RS18955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XACM_RS18975	COG0628	permease
XACM_RS18980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XACM_RS18985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XACM_RS19000	COG0753	catalase activity
XACM_RS19015	COG2197	response regulator
XACM_RS19020	COG4585	Histidine kinase
XACM_RS19025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_RS19030	COG1136	(ABC) transporter
XACM_RS19055	COG0697	spore germination
XACM_RS19070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XACM_RS19075	COG0180	Tryptophanyl-tRNA synthetase
XACM_RS19080	COG3237	CsbD-like
XACM_RS19120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XACM_RS19140	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XACM_RS19145	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XACM_RS19145	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XACM_RS19190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XACM_RS19215	COG1199	ATP-dependent helicase activity
XACM_RS19230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XACM_RS19280	COG0625	glutathione transferase activity
XACM_RS19320	COG4555	ABC transporter
XACM_RS19330	COG1476	TRANSCRIPTIONal
XACM_RS19355	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XACM_RS19360	COG1131	(ABC) transporter
XACM_RS19365	COG0842	Transport permease protein
XACM_RS19370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XACM_RS19400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XACM_RS19405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XACM_RS19415	COG0045	succinate-CoA ligase (ADP-forming) activity
XACM_RS19415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XACM_RS19415	COG1042	CoA-binding domain protein
XACM_RS19430	COG2239	Acts as a magnesium transporter
XACM_RS19455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XACM_RS19460	COG3387	PFAM Glycoside hydrolase 15-related
XACM_RS19470	COG3100	YcgL domain-containing protein
XACM_RS19475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XACM_RS19485	COG0463	Glycosyl transferase, family 2
XACM_RS19495	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS19530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XACM_RS19545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XACM_RS19580	COG0408	coproporphyrinogen oxidase activity
XACM_RS19625	COG0515	serine threonine protein kinase
XACM_RS19630	COG0631	protein serine/threonine phosphatase activity
XACM_RS19655	COG0667	Aldo Keto reductase
XACM_RS19660	COG0583	DNA-binding transcription factor activity
XACM_RS19810	COG0210	DNA helicase
XACM_RS19825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XACM_RS19830	COG0583	DNA-binding transcription factor activity
XACM_RS19835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XACM_RS19845	COG2159	amidohydrolase
XACM_RS19870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_RS19890	COG0357	Ribosomal RNA small subunit methyltransferase G
XACM_RS19895	COG3540	Alkaline phosphatase
XACM_RS19905	COG2091	lysine biosynthetic process via aminoadipic acid
XACM_RS19925	COG0708	Exodeoxyribonuclease III
XACM_RS19935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XACM_RS19940	COG3162	membrane
XACM_RS19950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XACM_RS19980	COG3507	Belongs to the glycosyl hydrolase 43 family
XACM_RS20000	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS20005	COG0179	Fumarylacetoacetate (FAA) hydrolase
XACM_RS20010	COG4948	Mandelate Racemase Muconate Lactonizing
XACM_RS20015	COG3254	rhamnose metabolic process
XACM_RS20020	COG0738	Major facilitator superfamily
XACM_RS20025	COG1414	Transcriptional regulator
XACM_RS20030	COG1971	Probably functions as a manganese efflux pump
XACM_RS20035	COG2205	protein histidine kinase activity
XACM_RS20050	COG3459	Glycosyltransferase 36 associated
XACM_RS20055	COG2211	Major facilitator Superfamily
XACM_RS20060	COG3265	gluconokinase activity
XACM_RS20065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XACM_RS20085	COG2911	Protein conserved in bacteria
XACM_RS20090	COG0729	surface antigen
XACM_RS20095	COG4771	TonB-dependent receptor
XACM_RS20100	COG2963	transposase activity
XACM_RS20105	COG2801	Transposase and inactivated derivatives
XACM_RS20115	COG0457	Tetratricopeptide repeat
XACM_RS20125	COG0752	glycyl-tRNA synthetase alpha subunit
XACM_RS20130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XACM_RS20145	COG0519	Catalyzes the synthesis of GMP from XMP
XACM_RS20145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XACM_RS20155	COG0805	protein transport
XACM_RS20160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XACM_RS20165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XACM_RS20175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XACM_RS20195	COG2974	May be involved in recombination
XACM_RS20200	COG0037	tRNA processing
XACM_RS20205	COG2115	Belongs to the xylose isomerase family
XACM_RS20215	COG3661	Belongs to the glycosyl hydrolase 67 family
XACM_RS20225	COG4948	Mandelate Racemase Muconate Lactonizing
XACM_RS20235	COG1472	Belongs to the glycosyl hydrolase 3 family
XACM_RS20240	COG0246	Mannitol dehydrogenase
XACM_RS20290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XACM_RS20315	COG3386	PFAM SMP-30 Gluconolaconase
XACM_RS20325	COG3250	beta-galactosidase activity
XACM_RS20330	COG1904	glucuronate isomerase
XACM_RS20335	COG3693	PFAM glycoside hydrolase, family 10
XACM_RS20345	COG3693	PFAM glycoside hydrolase, family 10
XACM_RS20360	COG2211	Major facilitator Superfamily
XACM_RS20380	COG2963	transposase activity
XACM_RS20385	COG2801	Transposase and inactivated derivatives
XACM_RS20400	COG0604	alcohol dehydrogenase
XACM_RS20400	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS20400	COG3321	synthase
XACM_RS20405	COG2937	Belongs to the GPAT DAPAT family
XACM_RS20440	COG0284	orotidine-5'-phosphate decarboxylase activity
XACM_RS20445	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XACM_RS20450	COG3132	Protein of unknown function, DUF480
XACM_RS20465	COG0210	DNA helicase
XACM_RS20470	COG1435	thymidine kinase activity
XACM_RS20480	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XACM_RS20490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XACM_RS20520	COG3135	benzoate transporter
XACM_RS20540	COG0676	glucose-6-phosphate 1-epimerase activity
XACM_RS20550	COG3012	SEC-C Motif Domain Protein
XACM_RS20555	COG0730	response to heat
XACM_RS20575	COG0302	gtp cyclohydrolase
XACM_RS20590	COG1566	PFAM secretion protein HlyD family protein
XACM_RS20600	COG1289	transmembrane transporter activity
XACM_RS20605	COG0477	Major facilitator Superfamily
XACM_RS20615	COG0583	DNA-binding transcription factor activity
XACM_RS20620	COG4221	oxidoreductase activity
XACM_RS20630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XACM_RS20670	COG2801	Transposase and inactivated derivatives
XACM_RS20675	COG2963	transposase activity
XACM_RS20700	COG0564	pseudouridine synthase activity
XACM_RS20730	COG1309	transcriptional regulator
XACM_RS20740	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_RS20780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XACM_RS20785	COG1074	ATP-dependent DNA helicase activity
XACM_RS20790	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XACM_RS20825	COG1127	ABC transporter
XACM_RS20830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XACM_RS20835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XACM_RS20850	COG2853	Lipoprotein
XACM_RS20855	COG0386	Belongs to the glutathione peroxidase family
XACM_RS20865	COG1322	Protein conserved in bacteria
XACM_RS20870	COG0604	alcohol dehydrogenase
XACM_RS20895	COG0531	amino acid
XACM_RS20900	COG3537	Alpha-1,2-mannosidase
XACM_RS20915	COG2203	Gaf domain
XACM_RS20915	COG2199	diguanylate cyclase activity
XACM_RS20920	COG3835	regulator
XACM_RS20925	COG1929	Belongs to the glycerate kinase type-1 family
XACM_RS20930	COG2271	Major facilitator Superfamily
XACM_RS20945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XACM_RS20950	COG0861	Integral membrane protein TerC family
XACM_RS20960	COG0584	glycerophosphoryl diester phosphodiesterase
XACM_RS20975	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XACM_RS20985	COG0706	membrane insertase activity
XACM_RS20990	COG0594	ribonuclease P activity
XACM_RS21050	COG0667	Aldo Keto reductase