locus-tag	class	description
Xcom_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Xcom_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Xcom_RS00020	COG0187	DNA topoisomerase II activity
Xcom_RS00030	COG0501	Belongs to the peptidase M48B family
Xcom_RS00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Xcom_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xcom_RS00125	COG0793	Belongs to the peptidase S41A family
Xcom_RS00130	COG4942	peptidase
Xcom_RS00140	COG2234	aminopeptidase activity
Xcom_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xcom_RS00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xcom_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xcom_RS00190	COG0493	'glutamate synthase
Xcom_RS00195	COG0067	glutamate synthase
Xcom_RS00195	COG0069	glutamate synthase activity
Xcom_RS00195	COG0070	glutamate synthase
Xcom_RS00285	COG1205	dead DEAH box helicase
Xcom_RS00285	COG1111	helicase
Xcom_RS00290	COG1272	protein, Hemolysin III
Xcom_RS00310	COG0300	oxidoreductase activity
Xcom_RS00315	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS00335	COG3237	CsbD-like
Xcom_RS00380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Xcom_RS00390	COG0477	Major facilitator Superfamily
Xcom_RS00430	COG0714	Associated with various cellular activities
Xcom_RS00480	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Xcom_RS00490	COG4772	TonB-dependent receptor
Xcom_RS00510	COG1012	belongs to the aldehyde dehydrogenase family
Xcom_RS00535	COG1304	FMN binding
Xcom_RS00550	COG1755	Isoprenylcysteine carboxyl methyltransferase
Xcom_RS00555	COG4585	Histidine kinase
Xcom_RS00560	COG2197	response regulator
Xcom_RS00580	COG3710	Transcriptional regulator
Xcom_RS00585	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Xcom_RS00595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Xcom_RS00640	COG0366	Alpha amylase catalytic
Xcom_RS00645	COG0366	Alpha amylase catalytic
Xcom_RS00650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Xcom_RS00665	COG2272	Belongs to the type-B carboxylesterase lipase family
Xcom_RS00670	COG2755	lipolytic protein G-D-S-L family
Xcom_RS00670	COG0657	acetylesterase activity
Xcom_RS00680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Xcom_RS00695	COG3507	Belongs to the glycosyl hydrolase 43 family
Xcom_RS00700	COG1609	Transcriptional regulator
Xcom_RS00705	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Xcom_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS00720	COG2755	lipolytic protein G-D-S-L family
Xcom_RS00730	COG3186	Phenylalanine-4-hydroxylase
Xcom_RS00735	COG1522	sequence-specific DNA binding
Xcom_RS00745	COG1752	Esterase of the alpha-beta hydrolase superfamily
Xcom_RS00750	COG1473	amidohydrolase
Xcom_RS00760	COG1119	ATPase activity
Xcom_RS00775	COG1125	glycine betaine transport
Xcom_RS00790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Xcom_RS00825	COG0489	protein tyrosine kinase activity
Xcom_RS00830	COG2062	phosphohistidine phosphatase, SixA
Xcom_RS00840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xcom_RS00885	COG1968	undecaprenyl-diphosphatase activity
Xcom_RS00895	COG0174	glutamine synthetase
Xcom_RS00900	COG0347	Belongs to the P(II) protein family
Xcom_RS00905	COG0004	ammonium transporteR
Xcom_RS00910	COG3852	Histidine kinase
Xcom_RS00915	COG2204	response regulator
Xcom_RS00920	COG2032	superoxide dismutase activity
Xcom_RS00925	COG2032	superoxide dismutase activity
Xcom_RS00935	COG0346	lactoylglutathione lyase activity
Xcom_RS00945	COG0183	Belongs to the thiolase family
Xcom_RS00980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Xcom_RS00985	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Xcom_RS00990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Xcom_RS01005	COG0028	Belongs to the TPP enzyme family
Xcom_RS01010	COG2205	protein histidine kinase activity
Xcom_RS01035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Xcom_RS01050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xcom_RS01055	COG3177	Filamentation induced by cAMP protein fic
Xcom_RS01060	COG0596	Alpha beta hydrolase
Xcom_RS01065	COG0727	PFAM Uncharacterised protein family (UPF0153)
Xcom_RS01070	COG0318	PFAM AMP-dependent synthetase and ligase
Xcom_RS01075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Xcom_RS01085	COG1181	Belongs to the D-alanine--D-alanine ligase family
Xcom_RS01100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Xcom_RS01110	COG0564	pseudouridine synthase activity
Xcom_RS01130	COG1446	asparaginase
Xcom_RS01135	COG0339	signal peptide processing
Xcom_RS01170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xcom_RS01180	COG4221	oxidoreductase activity
Xcom_RS01185	COG0583	DNA-binding transcription factor activity
Xcom_RS01195	COG0477	Major facilitator Superfamily
Xcom_RS01200	COG1289	transmembrane transporter activity
Xcom_RS01210	COG1566	PFAM secretion protein HlyD family protein
Xcom_RS01225	COG0302	gtp cyclohydrolase
Xcom_RS01245	COG0730	response to heat
Xcom_RS01250	COG3012	SEC-C Motif Domain Protein
Xcom_RS01260	COG0676	glucose-6-phosphate 1-epimerase activity
Xcom_RS01280	COG3135	benzoate transporter
Xcom_RS01310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Xcom_RS01320	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Xcom_RS01330	COG1435	thymidine kinase activity
Xcom_RS01335	COG0210	DNA helicase
Xcom_RS01355	COG3132	Protein of unknown function, DUF480
Xcom_RS01365	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
Xcom_RS01370	COG0284	orotidine-5'-phosphate decarboxylase activity
Xcom_RS01405	COG2937	Belongs to the GPAT DAPAT family
Xcom_RS01415	COG3321	synthase
Xcom_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS01415	COG0604	alcohol dehydrogenase
Xcom_RS01450	COG2211	Major facilitator Superfamily
Xcom_RS01465	COG3693	PFAM glycoside hydrolase, family 10
Xcom_RS01475	COG3693	PFAM glycoside hydrolase, family 10
Xcom_RS01480	COG1904	glucuronate isomerase
Xcom_RS01485	COG3250	beta-galactosidase activity
Xcom_RS01495	COG3386	PFAM SMP-30 Gluconolaconase
Xcom_RS01525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Xcom_RS01580	COG0246	Mannitol dehydrogenase
Xcom_RS01585	COG1472	Belongs to the glycosyl hydrolase 3 family
Xcom_RS01595	COG4948	Mandelate Racemase Muconate Lactonizing
Xcom_RS01605	COG3661	Belongs to the glycosyl hydrolase 67 family
Xcom_RS01615	COG2115	Belongs to the xylose isomerase family
Xcom_RS01630	COG2974	May be involved in recombination
Xcom_RS01655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Xcom_RS01665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Xcom_RS01670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Xcom_RS01675	COG0805	protein transport
Xcom_RS01685	COG0519	Catalyzes the synthesis of GMP from XMP
Xcom_RS01685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Xcom_RS01700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Xcom_RS01705	COG0752	glycyl-tRNA synthetase alpha subunit
Xcom_RS01720	COG0457	Tetratricopeptide repeat
Xcom_RS01725	COG4771	TonB-dependent receptor
Xcom_RS01730	COG0729	surface antigen
Xcom_RS01735	COG2911	Protein conserved in bacteria
Xcom_RS01755	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Xcom_RS01765	COG3265	gluconokinase activity
Xcom_RS01770	COG2211	Major facilitator Superfamily
Xcom_RS01775	COG3459	Glycosyltransferase 36 associated
Xcom_RS01790	COG2205	protein histidine kinase activity
Xcom_RS01795	COG1971	Probably functions as a manganese efflux pump
Xcom_RS01800	COG1414	Transcriptional regulator
Xcom_RS01805	COG0738	Major facilitator superfamily
Xcom_RS01810	COG3254	rhamnose metabolic process
Xcom_RS01815	COG4948	Mandelate Racemase Muconate Lactonizing
Xcom_RS01825	COG0179	Fumarylacetoacetate (FAA) hydrolase
Xcom_RS01830	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS01850	COG3507	Belongs to the glycosyl hydrolase 43 family
Xcom_RS01885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Xcom_RS01895	COG3162	membrane
Xcom_RS01900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Xcom_RS01910	COG0708	Exodeoxyribonuclease III
Xcom_RS01925	COG2091	lysine biosynthetic process via aminoadipic acid
Xcom_RS01935	COG3540	Alkaline phosphatase
Xcom_RS01940	COG0357	Ribosomal RNA small subunit methyltransferase G
Xcom_RS01965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_RS01995	COG2159	amidohydrolase
Xcom_RS02010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Xcom_RS02015	COG0583	DNA-binding transcription factor activity
Xcom_RS02020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xcom_RS02040	COG0210	DNA helicase
Xcom_RS02175	COG0583	DNA-binding transcription factor activity
Xcom_RS02180	COG0667	Aldo Keto reductase
Xcom_RS02205	COG0631	protein serine/threonine phosphatase activity
Xcom_RS02210	COG0515	serine threonine protein kinase
Xcom_RS02250	COG0408	coproporphyrinogen oxidase activity
Xcom_RS02300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Xcom_RS02315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Xcom_RS02345	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS02365	COG0463	Glycosyl transferase, family 2
Xcom_RS02380	COG3100	YcgL domain-containing protein
Xcom_RS02395	COG3387	PFAM Glycoside hydrolase 15-related
Xcom_RS02440	COG2239	Acts as a magnesium transporter
Xcom_RS02445	COG1042	CoA-binding domain protein
Xcom_RS02445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Xcom_RS02445	COG0045	succinate-CoA ligase (ADP-forming) activity
Xcom_RS02460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Xcom_RS02470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Xcom_RS02475	COG0716	FMN binding
Xcom_RS02500	COG0732	type I restriction modification DNA specificity domain
Xcom_RS02515	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
Xcom_RS02560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Xcom_RS02575	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS02585	COG3537	Alpha-1,2-mannosidase
Xcom_RS02595	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS02605	COG0492	ferredoxin-NADP+ reductase activity
Xcom_RS02650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Xcom_RS02655	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Xcom_RS02660	COG2080	2 iron, 2 sulfur cluster binding
Xcom_RS02695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Xcom_RS02710	COG0587	DNA-directed DNA polymerase activity
Xcom_RS02730	COG1297	OPT oligopeptide transporter protein
Xcom_RS02750	COG0823	Involved in the tonB-independent uptake of proteins
Xcom_RS02750	COG1506	peptidase
Xcom_RS02765	COG1917	Cupin 2, conserved barrel domain protein
Xcom_RS02765	COG2207	Transcriptional regulator
Xcom_RS02790	COG0753	catalase activity
Xcom_RS02795	COG0656	L-ascorbic acid biosynthetic process
Xcom_RS02800	COG2272	Belongs to the type-B carboxylesterase lipase family
Xcom_RS02805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Xcom_RS02805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Xcom_RS02850	COG2194	sulfuric ester hydrolase activity
Xcom_RS02865	COG0745	RESPONSE REGULATOR receiver
Xcom_RS02870	COG0642	Histidine kinase
Xcom_RS02880	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Xcom_RS02885	COG2894	cell division
Xcom_RS02890	COG0850	regulation of cytokinetic process
Xcom_RS02905	COG4585	Histidine kinase
Xcom_RS02910	COG2197	response regulator
Xcom_RS02925	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Xcom_RS02955	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Xcom_RS02975	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Xcom_RS02990	COG1595	DNA-templated transcription, initiation
Xcom_RS03000	COG1946	Acyl-CoA thioesterase
Xcom_RS03005	COG1024	Enoyl-CoA hydratase
Xcom_RS03015	COG0824	Thioesterase
Xcom_RS03020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Xcom_RS03025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Xcom_RS03030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Xcom_RS03035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Xcom_RS03040	COG0268	Binds directly to 16S ribosomal RNA
Xcom_RS03045	COG0728	peptidoglycan biosynthetic process
Xcom_RS03050	COG0196	riboflavin kinase activity
Xcom_RS03055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Xcom_RS03060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Xcom_RS03065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Xcom_RS03080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Xcom_RS03085	COG1845	cytochrome c oxidase, subunit III
Xcom_RS03090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Xcom_RS03105	COG3152	Membrane
Xcom_RS03115	COG2207	Transcriptional regulator
Xcom_RS03120	COG0326	Molecular chaperone. Has ATPase activity
Xcom_RS03130	COG1366	Belongs to the anti-sigma-factor antagonist family
Xcom_RS03140	COG2172	sigma factor antagonist activity
Xcom_RS03165	COG4771	TonB-dependent receptor
Xcom_RS03175	COG5507	3-demethylubiquinone-9 3-methyltransferase
Xcom_RS03180	COG2205	protein histidine kinase activity
Xcom_RS03190	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Xcom_RS03195	COG2205	protein histidine kinase activity
Xcom_RS03195	COG3437	response regulator, receiver
Xcom_RS03195	COG3850	Histidine kinase
Xcom_RS03195	COG4999	Histidine kinase
Xcom_RS03200	COG0784	Response regulator, receiver
Xcom_RS03200	COG4191	Histidine kinase
Xcom_RS03220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Xcom_RS03225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Xcom_RS03235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Xcom_RS03240	COG0228	four-way junction DNA binding
Xcom_RS03245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Xcom_RS03250	COG0336	Belongs to the RNA methyltransferase TrmD family
Xcom_RS03255	COG0335	large ribosomal subunit rRNA binding
Xcom_RS03260	COG0534	Mate efflux family protein
Xcom_RS03295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Xcom_RS03330	COG4221	oxidoreductase activity
Xcom_RS03345	COG0018	arginyl-trna synthetase
Xcom_RS03350	COG2003	Belongs to the UPF0758 family
Xcom_RS03355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Xcom_RS03360	COG0756	dUTP diphosphatase activity
Xcom_RS03380	COG0463	Glycosyl transferase, family 2
Xcom_RS03400	COG1475	DNA binding
Xcom_RS03405	COG1192	Involved in chromosome partitioning
Xcom_RS03415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Xcom_RS03420	COG0708	Exodeoxyribonuclease III
Xcom_RS03425	COG2211	Major facilitator Superfamily
Xcom_RS03435	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Xcom_RS03440	COG0739	heme binding
Xcom_RS03445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Xcom_RS03490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Xcom_RS03505	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Xcom_RS03535	COG0109	protoheme IX farnesyltransferase activity
Xcom_RS03550	COG0358	DNA primase activity
Xcom_RS03555	COG1295	ribonuclease BN
Xcom_RS03565	COG1610	YqeY-like protein
Xcom_RS03575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Xcom_RS03580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Xcom_RS03590	COG2133	pyrroloquinoline quinone binding
Xcom_RS03595	COG4682	membrane
Xcom_RS03610	COG0531	amino acid
Xcom_RS03620	COG4948	Mandelate Racemase Muconate Lactonizing
Xcom_RS03630	COG3023	N-Acetylmuramoyl-L-alanine amidase
Xcom_RS03635	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Xcom_RS03685	COG5383	Protein conserved in bacteria
Xcom_RS03695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xcom_RS03700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_RS03705	COG1473	amidohydrolase
Xcom_RS03715	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Xcom_RS03715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Xcom_RS03720	COG1652	LysM domain
Xcom_RS03740	COG0583	DNA-binding transcription factor activity
Xcom_RS03745	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Xcom_RS03755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Xcom_RS03760	COG3118	belongs to the thioredoxin family
Xcom_RS03765	COG0513	Belongs to the DEAD box helicase family
Xcom_RS03770	COG2884	Cell division ATP-binding protein ftsE
Xcom_RS03775	COG2177	Part of the ABC transporter FtsEX involved in
Xcom_RS03780	COG3437	response regulator, receiver
Xcom_RS03785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Xcom_RS03790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Xcom_RS03795	COG2860	membrane
Xcom_RS03800	COG1252	NADH dehydrogenase
Xcom_RS03815	COG0625	glutathione transferase activity
Xcom_RS03820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Xcom_RS03840	COG0534	Mate efflux family protein
Xcom_RS03845	COG0616	signal peptide processing
Xcom_RS03855	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS03870	COG0009	L-threonylcarbamoyladenylate synthase
Xcom_RS03875	COG1754	DNA topoisomerase type I activity
Xcom_RS03875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Xcom_RS03895	COG0758	DNA mediated transformation
Xcom_RS03900	COG1652	LysM domain
Xcom_RS03905	COG0242	peptide deformylase activity
Xcom_RS03910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Xcom_RS03915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Xcom_RS03915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Xcom_RS03965	COG1560	Kdo2-lipid A biosynthetic process
Xcom_RS03970	COG1490	D-aminoacyl-tRNA deacylase activity
Xcom_RS03975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Xcom_RS04000	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS04015	COG0024	Methionine aminopeptidase
Xcom_RS04025	COG0038	chloride channel
Xcom_RS04030	COG0659	secondary active sulfate transmembrane transporter activity
Xcom_RS04060	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Xcom_RS04065	COG0583	DNA-binding transcription factor activity
Xcom_RS04085	COG0251	oxidation-reduction process
Xcom_RS04160	COG1063	alcohol dehydrogenase
Xcom_RS04175	COG1132	(ABC) transporter
Xcom_RS04195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Xcom_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS04215	COG1294	oxidase, subunit
Xcom_RS04220	COG1271	oxidase subunit
Xcom_RS04270	COG3546	catalase activity
Xcom_RS04275	COG3685	Protein conserved in bacteria
Xcom_RS04295	COG2972	Histidine kinase
Xcom_RS04310	COG0531	amino acid
Xcom_RS04325	COG3590	peptidase
Xcom_RS04340	COG0667	Aldo Keto reductase
Xcom_RS04350	COG0583	DNA-binding transcription factor activity
Xcom_RS04355	COG3384	dioxygenase
Xcom_RS04365	COG1573	uracil-dna glycosylase
Xcom_RS04370	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Xcom_RS04380	COG0025	NhaP-type Na H and K H
Xcom_RS04385	COG1131	(ABC) transporter
Xcom_RS04390	COG0842	Transport permease protein
Xcom_RS04450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xcom_RS04455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Xcom_RS04480	COG2205	protein histidine kinase activity
Xcom_RS04480	COG2202	Pas domain
Xcom_RS04505	COG1187	pseudouridine synthase activity
Xcom_RS04510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Xcom_RS04535	COG0784	Response regulator, receiver
Xcom_RS04535	COG2198	Histidine kinase
Xcom_RS04535	COG5002	protein histidine kinase activity
Xcom_RS04545	COG1666	GTP binding
Xcom_RS04550	COG0697	spore germination
Xcom_RS04555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Xcom_RS04560	COG2011	ABC-type metal ion transport system permease component
Xcom_RS04615	COG0508	dehydrogenase complex catalyzes the overall conversion of
Xcom_RS04625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Xcom_RS04655	COG0356	it plays a direct role in the translocation of protons across the membrane
Xcom_RS04665	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Xcom_RS04670	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Xcom_RS04675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Xcom_RS04680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Xcom_RS04685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Xcom_RS04690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Xcom_RS04705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Xcom_RS04710	COG4191	Histidine kinase
Xcom_RS04725	COG0577	efflux transmembrane transporter activity
Xcom_RS04725	COG1136	(ABC) transporter
Xcom_RS04730	COG0577	efflux transmembrane transporter activity
Xcom_RS04735	COG1136	(ABC) transporter
Xcom_RS04740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_RS04745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Xcom_RS04780	COG2132	Multicopper oxidase
Xcom_RS04795	COG0339	signal peptide processing
Xcom_RS04810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Xcom_RS04820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Xcom_RS04835	COG1956	GAF domain-containing protein
Xcom_RS04840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Xcom_RS04850	COG0720	synthase
Xcom_RS04855	COG0513	Belongs to the DEAD box helicase family
Xcom_RS04870	COG0625	glutathione transferase activity
Xcom_RS04900	COG0626	cystathionine gamma-synthase activity
Xcom_RS04910	COG0438	transferase activity, transferring glycosyl groups
Xcom_RS04930	COG0438	transferase activity, transferring glycosyl groups
Xcom_RS04935	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Xcom_RS04970	COG0463	Glycosyl transferase, family 2
Xcom_RS04985	COG2086	electron transfer activity
Xcom_RS05015	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Xcom_RS05015	COG0662	Cupin 2, conserved barrel domain protein
Xcom_RS05020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Xcom_RS05025	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Xcom_RS05055	COG3218	ABC-type transport auxiliary lipoprotein component
Xcom_RS05055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Xcom_RS05060	COG1127	ABC transporter
Xcom_RS05065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Xcom_RS05080	COG0442	prolyl-tRNA aminoacylation
Xcom_RS05090	COG1183	phosphatidylcholine synthase activity
Xcom_RS05110	COG2801	Transposase and inactivated derivatives
Xcom_RS05130	COG0525	valine-tRNA ligase activity
Xcom_RS05145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Xcom_RS05155	COG0795	lipopolysaccharide-transporting ATPase activity
Xcom_RS05170	COG4974	Belongs to the 'phage' integrase family
Xcom_RS05185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Xcom_RS05195	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Xcom_RS05195	COG0047	phosphoribosylformylglycinamidine synthase activity
Xcom_RS05205	COG5295	Hep Hag repeat protein
Xcom_RS05210	COG1404	Belongs to the peptidase S8 family
Xcom_RS05215	COG5295	Hep Hag repeat protein
Xcom_RS05220	COG1404	Belongs to the peptidase S8 family
Xcom_RS05225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Xcom_RS05235	COG1459	type II secretion system
Xcom_RS05240	COG2165	general secretion pathway protein
Xcom_RS05245	COG4970	Tfp pilus assembly protein FimT
Xcom_RS05250	COG2165	general secretion pathway protein
Xcom_RS05255	COG4795	General secretion pathway protein
Xcom_RS05260	COG3156	type II secretion system protein K
Xcom_RS05265	COG3166	PFAM Fimbrial assembly family protein
Xcom_RS05280	COG1450	Type ii and iii secretion system protein
Xcom_RS05290	COG2188	Transcriptional regulator
Xcom_RS05340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Xcom_RS05355	COG1215	transferase activity, transferring glycosyl groups
Xcom_RS05360	COG1215	transferase activity, transferring glycosyl groups
Xcom_RS05365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Xcom_RS05370	COG0457	Tetratricopeptide repeat
Xcom_RS05400	COG0242	peptide deformylase activity
Xcom_RS05405	COG1307	EDD domain protein, DegV family
Xcom_RS05425	COG0402	S-adenosylhomocysteine deaminase activity
Xcom_RS05430	COG3964	amidohydrolase
Xcom_RS05445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Xcom_RS05450	COG0726	polysaccharide deacetylase
Xcom_RS05465	COG0436	Aminotransferase
Xcom_RS05470	COG1162	GTPase activity
Xcom_RS05495	COG2211	Major facilitator Superfamily
Xcom_RS05500	COG1609	Transcriptional regulator
Xcom_RS05505	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS05510	COG2851	Citrate transporter
Xcom_RS05530	COG0642	Histidine kinase
Xcom_RS05545	COG2197	response regulator
Xcom_RS05560	COG0667	Aldo Keto reductase
Xcom_RS05565	COG0583	DNA-binding transcription factor activity
Xcom_RS05595	COG1301	dicarboxylic acid transport
Xcom_RS05600	COG0281	malic enzyme
Xcom_RS05600	COG0280	phosphate acetyltransferase
Xcom_RS05625	COG1560	Kdo2-lipid A biosynthetic process
Xcom_RS05635	COG1519	Transferase
Xcom_RS05640	COG1538	Outer membrane efflux protein
Xcom_RS05645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Xcom_RS05665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Xcom_RS05670	COG0066	3-isopropylmalate dehydratase activity
Xcom_RS05675	COG0473	3-isopropylmalate dehydrogenase activity
Xcom_RS05680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Xcom_RS05700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Xcom_RS05705	COG0405	Gamma-glutamyltransferase
Xcom_RS05725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Xcom_RS05730	COG3710	Transcriptional regulator
Xcom_RS05750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Xcom_RS05760	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Xcom_RS05805	COG0563	adenylate kinase activity
Xcom_RS05810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Xcom_RS05820	COG3781	membrane
Xcom_RS05825	COG0671	phosphoesterase, PA-phosphatase related
Xcom_RS05835	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS05840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Xcom_RS05845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Xcom_RS05875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Xcom_RS05880	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
Xcom_RS05890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Xcom_RS05905	COG0352	thiamine-phosphate diphosphorylase activity
Xcom_RS05910	COG1773	rubredoxin
Xcom_RS05915	COG2912	Transglutaminase-like superfamily
Xcom_RS05925	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Xcom_RS05935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Xcom_RS05955	COG3079	Belongs to the UPF0149 family
Xcom_RS05960	COG0006	proline dipeptidase activity
Xcom_RS05970	COG0006	proline dipeptidase activity
Xcom_RS05985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Xcom_RS05990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Xcom_RS06000	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Xcom_RS06005	COG1561	YicC-like family, N-terminal region
Xcom_RS06010	COG0194	GDP metabolic process
Xcom_RS06020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Xcom_RS06030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Xcom_RS06035	COG1957	nucleoside hydrolase
Xcom_RS06060	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Xcom_RS06095	COG0714	Associated with various cellular activities
Xcom_RS06115	COG2304	oxidoreductase activity
Xcom_RS06130	COG1301	dicarboxylic acid transport
Xcom_RS06135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Xcom_RS06140	COG4773	Receptor
Xcom_RS06145	COG0739	heme binding
Xcom_RS06150	COG1376	ErfK ybiS ycfS ynhG family protein
Xcom_RS06185	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Xcom_RS06190	COG4149	molybdate abc transporter
Xcom_RS06195	COG0725	ABC transporter, periplasmic molybdate-binding protein
Xcom_RS06200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xcom_RS06200	COG3453	Protein conserved in bacteria
Xcom_RS06210	COG3047	cAMP biosynthetic process
Xcom_RS06215	COG3047	cAMP biosynthetic process
Xcom_RS06225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Xcom_RS06250	COG0126	phosphoglycerate kinase activity
Xcom_RS06260	COG0469	pyruvate kinase activity
Xcom_RS06270	COG3588	fructose-bisphosphate aldolase
Xcom_RS06275	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Xcom_RS06290	COG1648	precorrin-2 dehydrogenase activity
Xcom_RS06290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Xcom_RS06315	COG2205	protein histidine kinase activity
Xcom_RS06315	COG2198	Histidine kinase
Xcom_RS06315	COG0784	Response regulator, receiver
Xcom_RS06335	COG0175	sulfate reduction
Xcom_RS06340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Xcom_RS06345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Xcom_RS06350	COG0175	sulfate reduction
Xcom_RS06355	COG0529	Catalyzes the synthesis of activated sulfate
Xcom_RS06355	COG2895	sulfate adenylyltransferase (ATP) activity
Xcom_RS06370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xcom_RS06375	COG0308	aminopeptidase N
Xcom_RS06385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Xcom_RS06400	COG4948	Mandelate Racemase Muconate Lactonizing
Xcom_RS06405	COG3250	beta-galactosidase activity
Xcom_RS06415	COG1609	Transcriptional regulator
Xcom_RS06425	COG1970	mechanosensitive ion channel activity
Xcom_RS06450	COG0471	metal ion transport
Xcom_RS06450	COG3273	potassium ion transport
Xcom_RS06455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Xcom_RS06465	COG2022	thiamine diphosphate biosynthetic process
Xcom_RS06510	COG0189	ligase activity
Xcom_RS06520	COG0745	RESPONSE REGULATOR receiver
Xcom_RS06545	COG0237	dephospho-CoA kinase activity
Xcom_RS06550	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Xcom_RS06555	COG1459	type II secretion system
Xcom_RS06585	COG0045	succinate-CoA ligase (ADP-forming) activity
Xcom_RS06590	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Xcom_RS06605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Xcom_RS06605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Xcom_RS06615	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Xcom_RS06620	COG0564	pseudouridine synthase activity
Xcom_RS06635	COG3011	Protein conserved in bacteria
Xcom_RS06640	COG0840	transmembrane signaling receptor activity
Xcom_RS06660	COG3387	PFAM Glycoside hydrolase 15-related
Xcom_RS06665	COG1877	trehalose-phosphatase activity
Xcom_RS06720	COG0542	response to heat
Xcom_RS06725	COG4206	TonB-dependent receptor
Xcom_RS06745	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Xcom_RS06755	COG1492	cobalamin metabolic process
Xcom_RS06765	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Xcom_RS06785	COG0019	diaminopimelate decarboxylase activity
Xcom_RS06795	COG2814	Major facilitator Superfamily
Xcom_RS06800	COG4264	IucA IucC family
Xcom_RS06810	COG4772	TonB-dependent receptor
Xcom_RS06820	COG4651	solute:proton antiporter activity
Xcom_RS06820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Xcom_RS06880	COG0488	(ABC) transporter
Xcom_RS06900	COG2755	lipolytic protein G-D-S-L family
Xcom_RS06900	COG0657	acetylesterase activity
Xcom_RS06920	COG0477	Major facilitator Superfamily
Xcom_RS06935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Xcom_RS06950	COG0217	transcriptional regulatory protein
Xcom_RS06955	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Xcom_RS06960	COG0632	four-way junction helicase activity
Xcom_RS06965	COG3158	transport of potassium into the cell
Xcom_RS06975	COG2255	four-way junction helicase activity
Xcom_RS06980	COG0824	Thioesterase
Xcom_RS06990	COG0848	biopolymer transport protein
Xcom_RS07000	COG0823	Involved in the tonB-independent uptake of proteins
Xcom_RS07005	COG2885	chlorophyll binding
Xcom_RS07015	COG0602	queuosine metabolic process
Xcom_RS07025	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Xcom_RS07030	COG3920	Histidine kinase
Xcom_RS07050	COG0840	transmembrane signaling receptor activity
Xcom_RS07065	COG1187	pseudouridine synthase activity
Xcom_RS07100	COG0514	ATP-dependent DNA helicase (RecQ)
Xcom_RS07105	COG0783	Belongs to the Dps family
Xcom_RS07110	COG1643	Atp-dependent helicase
Xcom_RS07120	COG0837	glucose binding
Xcom_RS07140	COG0535	radical SAM domain protein
Xcom_RS07145	COG0535	radical SAM domain protein
Xcom_RS07150	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
Xcom_RS07155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Xcom_RS07165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Xcom_RS07180	COG1215	transferase activity, transferring glycosyl groups
Xcom_RS07185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Xcom_RS07195	COG1199	ATP-dependent helicase activity
Xcom_RS07200	COG1214	PFAM Peptidase M22, glycoprotease
Xcom_RS07220	COG0189	ligase activity
Xcom_RS07240	COG0840	transmembrane signaling receptor activity
Xcom_RS07245	COG2198	Histidine kinase
Xcom_RS07245	COG0784	Response regulator, receiver
Xcom_RS07245	COG0643	Histidine kinase
Xcom_RS07275	COG1595	DNA-templated transcription, initiation
Xcom_RS07280	COG2304	oxidoreductase activity
Xcom_RS07285	COG1446	asparaginase
Xcom_RS07290	COG3142	Participates in the control of copper homeostasis
Xcom_RS07330	COG3537	Alpha-1,2-mannosidase
Xcom_RS07340	COG1472	Belongs to the glycosyl hydrolase 3 family
Xcom_RS07355	COG3858	chitin binding
Xcom_RS07355	COG1388	LysM domain
Xcom_RS07370	COG0837	glucose binding
Xcom_RS07375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Xcom_RS07385	COG0494	nUDIX hydrolase
Xcom_RS07395	COG3956	TIGRFAM MazG family protein
Xcom_RS07400	COG1742	UPF0060 membrane protein
Xcom_RS07415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Xcom_RS07420	COG0509	glycine decarboxylation via glycine cleavage system
Xcom_RS07445	COG1960	acyl-CoA dehydrogenase activity
Xcom_RS07455	COG1309	transcriptional regulator
Xcom_RS07460	COG4771	TonB-dependent receptor
Xcom_RS07470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Xcom_RS07475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Xcom_RS07480	COG0463	Glycosyl transferase, family 2
Xcom_RS07485	COG0517	IMP dehydrogenase activity
Xcom_RS07485	COG0516	GMP reductase activity
Xcom_RS07490	COG2982	Protein involved in outer membrane biogenesis
Xcom_RS07495	COG1272	protein, Hemolysin III
Xcom_RS07500	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Xcom_RS07505	COG0739	heme binding
Xcom_RS07515	COG0626	cystathionine gamma-synthase activity
Xcom_RS07520	COG0460	homoserine dehydrogenase
Xcom_RS07520	COG0527	aspartate kinase activity
Xcom_RS07535	COG1760	l-serine dehydratase
Xcom_RS07555	COG2353	YceI-like domain
Xcom_RS07560	COG2205	protein histidine kinase activity
Xcom_RS07560	COG2198	Histidine kinase
Xcom_RS07560	COG0784	Response regulator, receiver
Xcom_RS07580	COG2814	Major facilitator Superfamily
Xcom_RS07585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Xcom_RS07595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Xcom_RS07600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Xcom_RS07605	COG0259	pyridoxamine-phosphate oxidase activity
Xcom_RS07615	COG1842	Phage shock protein A
Xcom_RS07640	COG0754	glutathionylspermidine amidase activity
Xcom_RS07645	COG2814	Major facilitator Superfamily
Xcom_RS07730	COG0531	amino acid
Xcom_RS07735	COG2197	response regulator
Xcom_RS07770	COG1113	amino acid transport
Xcom_RS07780	COG1271	oxidase subunit
Xcom_RS07785	COG1294	oxidase, subunit
Xcom_RS07795	COG2239	Acts as a magnesium transporter
Xcom_RS07805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Xcom_RS07810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Xcom_RS07820	COG1660	Displays ATPase and GTPase activities
Xcom_RS07825	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Xcom_RS07830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Xcom_RS07845	COG1137	ATPase activity
Xcom_RS07850	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Xcom_RS07860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Xcom_RS07870	COG0271	Belongs to the BolA IbaG family
Xcom_RS07875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Xcom_RS07895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Xcom_RS07905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Xcom_RS07915	COG0628	permease
Xcom_RS07925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Xcom_RS07945	COG1555	photosystem II stabilization
Xcom_RS07960	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Xcom_RS07965	COG1477	protein flavinylation
Xcom_RS07990	COG3128	pkhd-type hydroxylase
Xcom_RS07995	COG4774	siderophore transport
Xcom_RS08000	COG2146	nitrite reductase [NAD(P)H] activity
Xcom_RS08005	COG0456	acetyltransferase
Xcom_RS08010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Xcom_RS08015	COG0719	Fe-S assembly protein
Xcom_RS08020	COG0396	ATPase activity
Xcom_RS08025	COG0719	Fe-S assembly protein
Xcom_RS08030	COG1959	2 iron, 2 sulfur cluster binding
Xcom_RS08040	COG0693	protein deglycase activity
Xcom_RS08060	COG0739	heme binding
Xcom_RS08075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Xcom_RS08105	COG0519	Catalyzes the synthesis of GMP from XMP
Xcom_RS08115	COG1678	Uncharacterized ACR, COG1678
Xcom_RS08120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Xcom_RS08125	COG0540	Belongs to the ATCase OTCase family
Xcom_RS08130	COG1764	response to oxidative stress
Xcom_RS08140	COG0384	phenazine biosynthesis protein PhzF
Xcom_RS08145	COG0384	phenazine biosynthesis protein PhzF
Xcom_RS08150	COG0527	aspartate kinase activity
Xcom_RS08165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Xcom_RS08180	COG0142	geranyltranstransferase activity
Xcom_RS08185	COG0629	single-stranded DNA binding
Xcom_RS08190	COG4251	negative regulation of phosphorylation
Xcom_RS08190	COG2203	Gaf domain
Xcom_RS08190	COG3706	GGDEF domain
Xcom_RS08190	COG5001	Diguanylate cyclase
Xcom_RS08195	COG0604	alcohol dehydrogenase
Xcom_RS08195	COG3321	synthase
Xcom_RS08195	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS08200	COG2080	2 iron, 2 sulfur cluster binding
Xcom_RS08205	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Xcom_RS08210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Xcom_RS08215	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Xcom_RS08260	COG2879	small protein
Xcom_RS08270	COG1741	Belongs to the pirin family
Xcom_RS08285	COG1741	Belongs to the pirin family
Xcom_RS08300	COG1515	deoxyribonuclease V activity
Xcom_RS08305	COG0588	phosphoglycerate mutase activity
Xcom_RS08315	COG3590	peptidase
Xcom_RS08320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xcom_RS08325	COG2201	protein-glutamate methylesterase activity
Xcom_RS08330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Xcom_RS08335	COG2202	Pas domain
Xcom_RS08335	COG2200	EAL domain
Xcom_RS08335	COG2199	diguanylate cyclase activity
Xcom_RS08340	COG0835	chemotaxis
Xcom_RS08345	COG0840	transmembrane signaling receptor activity
Xcom_RS08350	COG2198	Histidine kinase
Xcom_RS08350	COG0643	Histidine kinase
Xcom_RS08360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Xcom_RS08375	COG0745	RESPONSE REGULATOR receiver
Xcom_RS08380	COG2205	protein histidine kinase activity
Xcom_RS08390	COG4452	Inner membrane protein CreD
Xcom_RS08415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Xcom_RS08420	COG0735	belongs to the Fur family
Xcom_RS08435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xcom_RS08445	COG1309	transcriptional regulator
Xcom_RS08460	COG2207	Transcriptional regulator
Xcom_RS08470	COG0583	DNA-binding transcription factor activity
Xcom_RS08480	COG0667	Aldo Keto reductase
Xcom_RS08600	COG5001	Diguanylate cyclase
Xcom_RS08600	COG5002	protein histidine kinase activity
Xcom_RS08605	COG1187	pseudouridine synthase activity
Xcom_RS08630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Xcom_RS08640	COG0475	glutathione-regulated potassium exporter activity
Xcom_RS08645	COG5002	protein histidine kinase activity
Xcom_RS08645	COG5000	phosphorelay sensor kinase activity
Xcom_RS08650	COG0745	RESPONSE REGULATOR receiver
Xcom_RS08655	COG1538	Outer membrane efflux protein
Xcom_RS08680	COG1132	(ABC) transporter
Xcom_RS08730	COG2155	Conserved Protein
Xcom_RS08765	COG3118	belongs to the thioredoxin family
Xcom_RS08775	COG0495	leucyl-tRNA aminoacylation
Xcom_RS08805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Xcom_RS08820	COG2968	Membrane
Xcom_RS08825	COG0424	maF-like protein
Xcom_RS08835	COG3164	Protein of unknown function
Xcom_RS08845	COG0312	modulator of DNA gyrase
Xcom_RS08850	COG3028	Belongs to the UPF0307 family
Xcom_RS08855	COG0312	modulator of DNA gyrase
Xcom_RS08865	COG4104	PAAR repeat-containing protein
Xcom_RS08870	COG0142	geranyltranstransferase activity
Xcom_RS08875	COG1722	exodeoxyribonuclease VII activity
Xcom_RS08880	COG0037	tRNA processing
Xcom_RS08890	COG1785	Belongs to the alkaline phosphatase family
Xcom_RS08895	COG1301	dicarboxylic acid transport
Xcom_RS08910	COG0791	NLP P60 protein
Xcom_RS08915	COG0791	NLP P60 protein
Xcom_RS08920	COG1047	Peptidyl-prolyl cis-trans
Xcom_RS08925	COG2311	Membrane
Xcom_RS08930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xcom_RS08935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Xcom_RS08955	COG3590	peptidase
Xcom_RS08965	COG3590	peptidase
Xcom_RS08985	COG0489	protein tyrosine kinase activity
Xcom_RS08995	COG0717	Belongs to the dCTP deaminase family
Xcom_RS09020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Xcom_RS09025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Xcom_RS09045	COG0494	nUDIX hydrolase
Xcom_RS09050	COG0433	COG0433 Predicted ATPase
Xcom_RS09060	COG0688	phosphatidylethanolamine metabolic process
Xcom_RS09070	COG2890	protein-(glutamine-N5) methyltransferase activity
Xcom_RS09075	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Xcom_RS09080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Xcom_RS09085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Xcom_RS09100	COG0101	tRNA pseudouridine synthase activity
Xcom_RS09105	COG0135	phosphoribosylanthranilate isomerase activity
Xcom_RS09115	COG0133	tryptophan synthase activity
Xcom_RS09125	COG0159	tryptophan synthase activity
Xcom_RS09130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Xcom_RS09135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Xcom_RS09180	COG4221	oxidoreductase activity
Xcom_RS09185	COG0149	triose-phosphate isomerase activity
Xcom_RS09200	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xcom_RS09205	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xcom_RS09210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xcom_RS09215	COG0649	NAD binding
Xcom_RS09220	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Xcom_RS09225	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Xcom_RS09230	COG1034	ATP synthesis coupled electron transport
Xcom_RS09235	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Xcom_RS09240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xcom_RS09265	COG1007	ATP synthesis coupled electron transport
Xcom_RS09275	COG0779	Required for maturation of 30S ribosomal subunits
Xcom_RS09280	COG0195	Participates in both transcription termination and antitermination
Xcom_RS09285	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Xcom_RS09290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Xcom_RS09295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Xcom_RS09300	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Xcom_RS09305	COG1185	polyribonucleotide nucleotidyltransferase activity
Xcom_RS09340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Xcom_RS09350	COG2095	MarC family integral membrane protein
Xcom_RS09365	COG1611	Belongs to the LOG family
Xcom_RS09410	COG0556	nucleotide-excision repair
Xcom_RS09430	COG3505	Type IV secretory pathway VirD4
Xcom_RS09450	COG1082	Xylose isomerase domain protein TIM barrel
Xcom_RS09475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Xcom_RS09480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Xcom_RS09495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Xcom_RS09500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Xcom_RS09500	COG0072	phenylalanine-tRNA ligase activity
Xcom_RS09550	COG0438	transferase activity, transferring glycosyl groups
Xcom_RS09555	COG0438	transferase activity, transferring glycosyl groups
Xcom_RS09565	COG0438	transferase activity, transferring glycosyl groups
Xcom_RS09590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xcom_RS09595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xcom_RS09600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Xcom_RS09620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Xcom_RS09630	COG1960	acyl-CoA dehydrogenase activity
Xcom_RS09640	COG3040	lipid binding
Xcom_RS09655	COG0322	excinuclease ABC activity
Xcom_RS09670	COG0784	Response regulator, receiver
Xcom_RS09670	COG4191	Histidine kinase
Xcom_RS09680	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Xcom_RS09685	COG1194	a g-specific adenine glycosylase
Xcom_RS09695	COG0552	protein localization to endoplasmic reticulum
Xcom_RS09705	COG3938	Belongs to the proline racemase family
Xcom_RS09710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xcom_RS09725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Xcom_RS09735	COG0006	proline dipeptidase activity
Xcom_RS09750	COG0531	amino acid
Xcom_RS09830	COG0326	Molecular chaperone. Has ATPase activity
Xcom_RS09835	COG0742	ribosomal rna small subunit methyltransferase
Xcom_RS09840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Xcom_RS09855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Xcom_RS09860	COG0405	Gamma-glutamyltransferase
Xcom_RS09865	COG3291	Pkd domain containing protein
Xcom_RS09870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Xcom_RS09910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Xcom_RS09915	COG0343	queuine tRNA-ribosyltransferase activity
Xcom_RS09920	COG1862	Preprotein translocase
Xcom_RS09930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Xcom_RS09970	COG1501	Belongs to the glycosyl hydrolase 31 family
Xcom_RS09980	COG1070	Carbohydrate kinase
Xcom_RS09985	COG2115	Belongs to the xylose isomerase family
Xcom_RS09990	COG0477	Major facilitator Superfamily
Xcom_RS10010	COG0860	N-Acetylmuramoyl-L-alanine amidase
Xcom_RS10015	COG1469	GTP cyclohydrolase I activity
Xcom_RS10035	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Xcom_RS10040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Xcom_RS10045	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Xcom_RS10050	COG0166	Belongs to the GPI family
Xcom_RS10075	COG1472	Belongs to the glycosyl hydrolase 3 family
Xcom_RS10090	COG3706	GGDEF domain
Xcom_RS10090	COG2203	Gaf domain
Xcom_RS10090	COG4251	negative regulation of phosphorylation
Xcom_RS10090	COG5001	Diguanylate cyclase
Xcom_RS10100	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xcom_RS10105	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Xcom_RS10115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Xcom_RS10120	COG0671	phosphoesterase, PA-phosphatase related
Xcom_RS10130	COG1794	racemase activity, acting on amino acids and derivatives
Xcom_RS10135	COG0697	spore germination
Xcom_RS10140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Xcom_RS10145	COG0167	dihydroorotate dehydrogenase activity
Xcom_RS10165	COG1012	belongs to the aldehyde dehydrogenase family
Xcom_RS10180	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Xcom_RS10200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Xcom_RS10210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Xcom_RS10215	COG0124	histidyl-tRNA synthetase
Xcom_RS10225	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Xcom_RS10230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Xcom_RS10235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Xcom_RS10240	COG0131	Imidazoleglycerol-phosphate dehydratase
Xcom_RS10240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Xcom_RS10245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Xcom_RS10250	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Xcom_RS10255	COG0107	imidazoleglycerol-phosphate synthase activity
Xcom_RS10260	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Xcom_RS10260	COG0140	phosphoribosyl-ATP diphosphatase activity
Xcom_RS10275	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Xcom_RS10280	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Xcom_RS10285	COG0235	Class ii aldolase
Xcom_RS10290	COG0531	amino acid
Xcom_RS10295	COG0531	amino acid
Xcom_RS10305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Xcom_RS10310	COG0277	FAD linked oxidase domain protein
Xcom_RS10330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Xcom_RS10375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Xcom_RS10380	COG2258	MOSC domain
Xcom_RS10390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Xcom_RS10395	COG0505	Belongs to the CarA family
Xcom_RS10405	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Xcom_RS10410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Xcom_RS10420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Xcom_RS10430	COG3279	Response regulator of the LytR AlgR family
Xcom_RS10440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Xcom_RS10450	COG2205	protein histidine kinase activity
Xcom_RS10450	COG2198	Histidine kinase
Xcom_RS10450	COG0784	Response regulator, receiver
Xcom_RS10455	COG0784	Response regulator, receiver
Xcom_RS10455	COG2198	Histidine kinase
Xcom_RS10455	COG2205	protein histidine kinase activity
Xcom_RS10460	COG1024	Enoyl-CoA hydratase
Xcom_RS10465	COG0318	PFAM AMP-dependent synthetase and ligase
Xcom_RS10500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Xcom_RS10510	COG2201	protein-glutamate methylesterase activity
Xcom_RS10515	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Xcom_RS10525	COG0840	transmembrane signaling receptor activity
Xcom_RS10535	COG0835	chemotaxis
Xcom_RS10555	COG0840	transmembrane signaling receptor activity
Xcom_RS10560	COG0840	transmembrane signaling receptor activity
Xcom_RS10570	COG0840	transmembrane signaling receptor activity
Xcom_RS10580	COG0840	transmembrane signaling receptor activity
Xcom_RS10585	COG0840	transmembrane signaling receptor activity
Xcom_RS10590	COG0840	transmembrane signaling receptor activity
Xcom_RS10595	COG0840	transmembrane signaling receptor activity
Xcom_RS10605	COG0840	transmembrane signaling receptor activity
Xcom_RS10635	COG0745	RESPONSE REGULATOR receiver
Xcom_RS10655	COG1360	Flagellar Motor Protein
Xcom_RS10660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Xcom_RS10680	COG0784	Response regulator, receiver
Xcom_RS10680	COG0643	Histidine kinase
Xcom_RS10680	COG2198	Histidine kinase
Xcom_RS10710	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Xcom_RS10740	COG1684	flagellar biosynthetic protein fliR
Xcom_RS10790	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS10800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xcom_RS10820	COG2201	protein-glutamate methylesterase activity
Xcom_RS10850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Xcom_RS10855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Xcom_RS10860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Xcom_RS10870	COG1705	Flagellar rod assembly protein muramidase FlgJ
Xcom_RS10870	COG3951	Flagellar rod assembly protein muramidase FlgJ
Xcom_RS10875	COG1706	bacterial-type flagellum-dependent cell motility
Xcom_RS10880	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Xcom_RS10895	COG4787	bacterial-type flagellum-dependent cell motility
Xcom_RS10905	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Xcom_RS10910	COG1558	bacterial-type flagellum-dependent cell motility
Xcom_RS10920	COG0784	Response regulator, receiver
Xcom_RS10920	COG0835	chemotaxis
Xcom_RS10940	COG5002	protein histidine kinase activity
Xcom_RS10975	COG2915	High frequency lysogenization protein hflD homolog
Xcom_RS10980	COG0482	sulfurtransferase activity
Xcom_RS10995	COG0542	response to heat
Xcom_RS11005	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Xcom_RS11020	COG0492	ferredoxin-NADP+ reductase activity
Xcom_RS11025	COG1674	ftsk spoiiie
Xcom_RS11035	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Xcom_RS11050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Xcom_RS11055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Xcom_RS11060	COG0183	Belongs to the thiolase family
Xcom_RS11065	COG1250	3-hydroxyacyl-CoA dehydrogenase
Xcom_RS11065	COG1024	Enoyl-CoA hydratase
Xcom_RS11080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Xcom_RS11090	COG1426	Protein conserved in bacteria
Xcom_RS11100	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Xcom_RS11105	COG1160	GTP binding
Xcom_RS11110	COG0303	'Molybdopterin
Xcom_RS11115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Xcom_RS11155	COG0708	Exodeoxyribonuclease III
Xcom_RS11165	COG0303	'Molybdopterin
Xcom_RS11170	COG0746	molybdenum cofactor guanylyltransferase activity
Xcom_RS11195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Xcom_RS11195	COG1648	precorrin-2 dehydrogenase activity
Xcom_RS11205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Xcom_RS11210	COG2223	nitrite transmembrane transporter activity
Xcom_RS11215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Xcom_RS11225	COG0243	molybdopterin cofactor binding
Xcom_RS11245	COG3685	Protein conserved in bacteria
Xcom_RS11260	COG5001	Diguanylate cyclase
Xcom_RS11270	COG4566	intracellular signal transduction
Xcom_RS11290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_RS11310	COG3275	phosphorelay sensor kinase activity
Xcom_RS11315	COG3279	Response regulator of the LytR AlgR family
Xcom_RS11455	COG0800	Aldolase
Xcom_RS11460	COG0129	dihydroxy-acid dehydratase activity
Xcom_RS11465	COG0363	glucosamine-6-phosphate deaminase activity
Xcom_RS11470	COG0837	glucose binding
Xcom_RS11475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Xcom_RS11485	COG0354	folic acid binding
Xcom_RS11500	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Xcom_RS11515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Xcom_RS11520	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Xcom_RS11530	COG4591	ABC-type transport system involved in lipoprotein release permease component
Xcom_RS11535	COG1136	(ABC) transporter
Xcom_RS11550	COG0811	peptide transport
Xcom_RS11560	COG1132	(ABC) transporter
Xcom_RS11565	COG1663	tetraacyldisaccharide 4'-kinase activity
Xcom_RS11570	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Xcom_RS11575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Xcom_RS11585	COG0322	excinuclease ABC activity
Xcom_RS11590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Xcom_RS11615	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Xcom_RS11635	COG1054	Belongs to the UPF0176 family
Xcom_RS11645	COG1530	ribonuclease E activity
Xcom_RS11655	COG3064	Membrane
Xcom_RS11660	COG0428	transporter
Xcom_RS11670	COG2154	pterin-4-alpha-carbinolamine dehydratase
Xcom_RS11675	COG0316	Belongs to the HesB IscA family
Xcom_RS11675	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Xcom_RS11690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_RS11695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xcom_RS11710	COG0596	Alpha beta hydrolase
Xcom_RS11745	COG0363	glucosamine-6-phosphate deaminase activity
Xcom_RS11760	COG2226	methyltransferase
Xcom_RS11760	COG1073	alpha beta
Xcom_RS11770	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS11800	COG0640	Transcriptional regulator
Xcom_RS11895	COG2205	protein histidine kinase activity
Xcom_RS11895	COG0784	Response regulator, receiver
Xcom_RS11900	COG2183	response to ionizing radiation
Xcom_RS11910	COG0723	plastoquinol--plastocyanin reductase activity
Xcom_RS11910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xcom_RS11925	COG3243	poly(R)-hydroxyalkanoic acid synthase
Xcom_RS11935	COG1183	phosphatidylcholine synthase activity
Xcom_RS11940	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS11955	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Xcom_RS11965	COG0668	transmembrane transport
Xcom_RS11970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Xcom_RS11985	COG1914	H( )-stimulated, divalent metal cation uptake system
Xcom_RS12005	COG2814	Major facilitator Superfamily
Xcom_RS12020	COG1335	isochorismatase
Xcom_RS12030	COG4585	Histidine kinase
Xcom_RS12035	COG2197	response regulator
Xcom_RS12055	COG0583	DNA-binding transcription factor activity
Xcom_RS12075	COG0633	Ferredoxin
Xcom_RS12085	COG0583	DNA-binding transcription factor activity
Xcom_RS12090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Xcom_RS12095	COG3002	Belongs to the UPF0753 family
Xcom_RS12105	COG0583	DNA-binding transcription factor activity
Xcom_RS12150	COG2951	lytic endotransglycosylase activity
Xcom_RS12165	COG2197	response regulator
Xcom_RS12170	COG4585	Histidine kinase
Xcom_RS12185	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Xcom_RS12200	COG1858	cytochrome C peroxidase
Xcom_RS12230	COG0515	serine threonine protein kinase
Xcom_RS12235	COG0631	protein serine/threonine phosphatase activity
Xcom_RS12285	COG0582	viral genome integration into host DNA
Xcom_RS12290	COG0519	Catalyzes the synthesis of GMP from XMP
Xcom_RS12290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Xcom_RS12300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Xcom_RS12310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Xcom_RS12310	COG0475	glutathione-regulated potassium exporter activity
Xcom_RS12320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Xcom_RS12330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Xcom_RS12335	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Xcom_RS12345	COG0776	regulation of translation
Xcom_RS12350	COG0539	negative regulation of cytoplasmic translation
Xcom_RS12355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Xcom_RS12370	COG2957	Belongs to the agmatine deiminase family
Xcom_RS12375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Xcom_RS12400	COG0395	ABC-type sugar transport system, permease component
Xcom_RS12405	COG1175	transmembrane transport
Xcom_RS12435	COG2350	Protein conserved in bacteria
Xcom_RS12440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Xcom_RS12445	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Xcom_RS12450	COG1187	pseudouridine synthase activity
Xcom_RS12470	COG0436	Aminotransferase
Xcom_RS12475	COG4133	protoheme IX ABC transporter activity
Xcom_RS12495	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Xcom_RS12500	COG1138	Cytochrome C-type biogenesis protein
Xcom_RS12520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Xcom_RS12525	COG1278	Cold shock
Xcom_RS12530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Xcom_RS12535	COG4988	ABC transporter
Xcom_RS12545	COG1294	oxidase, subunit
Xcom_RS12575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Xcom_RS12580	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Xcom_RS12590	COG0165	Argininosuccinate lyase
Xcom_RS12595	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Xcom_RS12605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Xcom_RS12610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Xcom_RS12620	COG0137	argininosuccinate synthase activity
Xcom_RS12625	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Xcom_RS12635	COG0215	cysteine-tRNA ligase activity
Xcom_RS12640	COG2166	iron-sulfur cluster assembly
Xcom_RS12655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Xcom_RS12660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Xcom_RS12690	COG4302	ethanolamine ammonia-lyase activity
Xcom_RS12715	COG4677	pectinesterase activity
Xcom_RS12730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Xcom_RS12735	COG0402	S-adenosylhomocysteine deaminase activity
Xcom_RS12745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Xcom_RS12750	COG1509	lysine 2,3-aminomutase activity
Xcom_RS12755	COG3300	MHYT domain
Xcom_RS12755	COG5001	Diguanylate cyclase
Xcom_RS12770	COG0483	inositol monophosphate 1-phosphatase activity
Xcom_RS12775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Xcom_RS12790	COG0488	(ABC) transporter
Xcom_RS12795	COG0513	Belongs to the DEAD box helicase family
Xcom_RS12800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Xcom_RS12805	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Xcom_RS12815	COG0625	glutathione transferase activity
Xcom_RS12825	COG4681	YaeQ
Xcom_RS12830	COG2081	HI0933 family
Xcom_RS12840	COG0501	Belongs to the peptidase M48B family
Xcom_RS12845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Xcom_RS12850	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS12875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Xcom_RS12880	COG0860	N-Acetylmuramoyl-L-alanine amidase
Xcom_RS12885	COG0802	atpase or kinase
Xcom_RS12890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Xcom_RS12890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Xcom_RS12895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Xcom_RS12900	COG1570	exodeoxyribonuclease VII activity
Xcom_RS12915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Xcom_RS12965	COG0835	chemotaxis
Xcom_RS12970	COG0840	transmembrane signaling receptor activity
Xcom_RS12975	COG2094	Belongs to the DNA glycosylase MPG family
Xcom_RS12980	COG1201	RNA secondary structure unwinding
Xcom_RS13000	COG2969	positive regulation of protein catabolic process
Xcom_RS13005	COG0625	glutathione transferase activity
Xcom_RS13010	COG2857	Cytochrome c1
Xcom_RS13015	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Xcom_RS13020	COG0723	plastoquinol--plastocyanin reductase activity
Xcom_RS13030	COG0741	lytic transglycosylase activity
Xcom_RS13045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Xcom_RS13050	COG1702	phosphate starvation-inducible protein PhoH
Xcom_RS13060	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Xcom_RS13070	COG4535	Mg2 and Co2 transporter CorC
Xcom_RS13085	COG1012	belongs to the aldehyde dehydrogenase family
Xcom_RS13090	COG1177	transmembrane transport
Xcom_RS13095	COG1176	ABC-type spermidine putrescine transport system, permease component I
Xcom_RS13105	COG3842	ATPase activity
Xcom_RS13125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Xcom_RS13140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Xcom_RS13145	COG0174	glutamine synthetase
Xcom_RS13150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xcom_RS13160	COG2703	oxygen carrier activity
Xcom_RS13165	COG0477	Major facilitator Superfamily
Xcom_RS13175	COG0243	molybdopterin cofactor binding
Xcom_RS13180	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Xcom_RS13185	COG2223	nitrite transmembrane transporter activity
Xcom_RS13195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Xcom_RS13205	COG2733	membrane
Xcom_RS13210	COG5002	protein histidine kinase activity
Xcom_RS13210	COG2205	protein histidine kinase activity
Xcom_RS13210	COG0784	Response regulator, receiver
Xcom_RS13220	COG0477	Major facilitator Superfamily
Xcom_RS13225	COG2902	Dehydrogenase
Xcom_RS13235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_RS13240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xcom_RS13245	COG1609	Transcriptional regulator
Xcom_RS13250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Xcom_RS13250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Xcom_RS13255	COG1105	Belongs to the carbohydrate kinase PfkB family
Xcom_RS13260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Xcom_RS13260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Xcom_RS13300	COG0800	Aldolase
Xcom_RS13305	COG4948	Mandelate Racemase Muconate Lactonizing
Xcom_RS13315	COG3734	2-keto-3-deoxy-galactonokinase
Xcom_RS13320	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Xcom_RS13330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Xcom_RS13345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Xcom_RS13350	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Xcom_RS13365	COG0351	phosphomethylpyrimidine kinase
Xcom_RS13390	COG0583	DNA-binding transcription factor activity
Xcom_RS13395	COG1741	Belongs to the pirin family
Xcom_RS13415	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Xcom_RS13420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Xcom_RS13425	COG2137	regulation of response to DNA damage stimulus
Xcom_RS13435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Xcom_RS13440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Xcom_RS13450	COG1546	Belongs to the CinA family
Xcom_RS13455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Xcom_RS13465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Xcom_RS13470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Xcom_RS13480	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Xcom_RS13485	COG1534	Rna-binding protein
Xcom_RS13500	COG1238	metal cluster binding
Xcom_RS13505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Xcom_RS13510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Xcom_RS13515	COG2840	Smr protein MutS2
Xcom_RS13520	COG0585	pseudouridine synthase activity
Xcom_RS13525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Xcom_RS13530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Xcom_RS13535	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Xcom_RS13540	COG0148	phosphopyruvate hydratase activity
Xcom_RS13550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Xcom_RS13555	COG0504	CTP synthase activity
Xcom_RS13580	COG0306	phosphate transporter
Xcom_RS13595	COG1253	flavin adenine dinucleotide binding
Xcom_RS13610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xcom_RS13615	COG2271	Major facilitator Superfamily
Xcom_RS13620	COG1132	(ABC) transporter
Xcom_RS13625	COG1136	(ABC) transporter
Xcom_RS13645	COG0438	transferase activity, transferring glycosyl groups
Xcom_RS13655	COG2264	protein methyltransferase activity
Xcom_RS13680	COG1442	glycosyl transferase family 8
Xcom_RS13680	COG1216	Glycosyl transferase, family 2
Xcom_RS13685	COG2244	polysaccharide biosynthetic process
Xcom_RS13740	COG1595	DNA-templated transcription, initiation
Xcom_RS13755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Xcom_RS13765	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Xcom_RS13775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Xcom_RS13790	COG4191	Histidine kinase
Xcom_RS13790	COG0784	Response regulator, receiver
Xcom_RS13795	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Xcom_RS13825	COG0840	transmembrane signaling receptor activity
Xcom_RS13880	COG0583	DNA-binding transcription factor activity
Xcom_RS13885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Xcom_RS13890	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Xcom_RS13905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Xcom_RS13910	COG1605	Chorismate mutase
Xcom_RS13910	COG0077	Prephenate dehydratase
Xcom_RS13915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Xcom_RS13920	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Xcom_RS13925	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Xcom_RS13965	COG1228	amidohydrolase
Xcom_RS13970	COG2986	histidine ammonia-lyase
Xcom_RS13980	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Xcom_RS13990	COG4993	Dehydrogenase
Xcom_RS14000	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Xcom_RS14015	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Xcom_RS14020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Xcom_RS14025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Xcom_RS14035	COG3115	cell septum assembly
Xcom_RS14045	COG0359	binds to the 23S rRNA
Xcom_RS14050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Xcom_RS14055	COG0360	Binds together with S18 to 16S ribosomal RNA
Xcom_RS14060	COG0316	Belongs to the HesB IscA family
Xcom_RS14070	COG0017	Asparaginyl-tRNA synthetase
Xcom_RS14140	COG0288	reversible hydration of carbon dioxide
Xcom_RS14145	COG0662	Cupin 2, conserved barrel domain protein
Xcom_RS14155	COG3844	kynureninase activity
Xcom_RS14160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Xcom_RS14170	COG2925	Exonuclease
Xcom_RS14190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Xcom_RS14195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Xcom_RS14195	COG0116	Belongs to the methyltransferase superfamily
Xcom_RS14240	COG0494	nUDIX hydrolase
Xcom_RS14250	COG1024	Enoyl-CoA hydratase
Xcom_RS14260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Xcom_RS14265	COG0659	secondary active sulfate transmembrane transporter activity
Xcom_RS14290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Xcom_RS14295	COG0573	inorganic phosphate transmembrane transporter activity
Xcom_RS14300	COG0581	inorganic phosphate transmembrane transporter activity
Xcom_RS14305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Xcom_RS14310	COG0704	Plays a role in the regulation of phosphate uptake
Xcom_RS14320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Xcom_RS14340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Xcom_RS14355	COG0557	exoribonuclease II activity
Xcom_RS14380	COG1960	acyl-CoA dehydrogenase activity
Xcom_RS14385	COG2226	methyltransferase
Xcom_RS14390	COG0646	methionine synthase
Xcom_RS14390	COG1410	methionine synthase
Xcom_RS14395	COG0646	methionine synthase
Xcom_RS14395	COG1410	methionine synthase
Xcom_RS14405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Xcom_RS14430	COG2900	Belongs to the SlyX family
Xcom_RS14445	COG0386	Belongs to the glutathione peroxidase family
Xcom_RS14455	COG1725	Transcriptional regulator
Xcom_RS14460	COG1131	(ABC) transporter
Xcom_RS14495	COG1253	flavin adenine dinucleotide binding
Xcom_RS14515	COG2850	peptidyl-arginine hydroxylation
Xcom_RS14550	COG1132	(ABC) transporter
Xcom_RS14560	COG0583	DNA-binding transcription factor activity
Xcom_RS14590	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Xcom_RS14600	COG0484	heat shock protein binding
Xcom_RS14605	COG0443	Heat shock 70 kDa protein
Xcom_RS14610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Xcom_RS14615	COG1420	regulation of RNA biosynthetic process
Xcom_RS14620	COG0497	DNA recombination
Xcom_RS14630	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Xcom_RS14645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Xcom_RS14675	COG3706	GGDEF domain
Xcom_RS14720	COG0583	DNA-binding transcription factor activity
Xcom_RS14735	COG0415	Belongs to the DNA photolyase family
Xcom_RS14740	COG0305	Participates in initiation and elongation during chromosome replication
Xcom_RS14750	COG0367	asparagine synthase
Xcom_RS14770	COG1960	acyl-CoA dehydrogenase activity
Xcom_RS14785	COG0084	hydrolase, TatD family'
Xcom_RS14850	COG0386	Belongs to the glutathione peroxidase family
Xcom_RS14855	COG0339	signal peptide processing
Xcom_RS14920	COG2814	Major facilitator Superfamily
Xcom_RS14925	COG1566	PFAM secretion protein HlyD family protein
Xcom_RS14950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Xcom_RS14965	COG4774	siderophore transport
Xcom_RS14975	COG0367	asparagine synthase
Xcom_RS14980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Xcom_RS14985	COG1393	Belongs to the ArsC family
Xcom_RS14995	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Xcom_RS15035	COG0052	Belongs to the universal ribosomal protein uS2 family
Xcom_RS15040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Xcom_RS15050	COG0528	UMP kinase activity
Xcom_RS15055	COG0233	cytoplasmic translational termination
Xcom_RS15060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Xcom_RS15065	COG0575	Belongs to the CDS family
Xcom_RS15070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Xcom_RS15075	COG0750	zinc metalloprotease
Xcom_RS15090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Xcom_RS15095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Xcom_RS15100	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Xcom_RS15105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Xcom_RS15120	COG0825	malonyl-CoA metabolic process
Xcom_RS15135	COG1981	membrane
Xcom_RS15155	COG1695	Transcriptional regulator
Xcom_RS15175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Xcom_RS15185	COG2040	homocysteine
Xcom_RS15215	COG0346	lactoylglutathione lyase activity
Xcom_RS15235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Xcom_RS15235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Xcom_RS15245	COG2878	Part of a membrane complex involved in electron transport
Xcom_RS15260	COG1595	DNA-templated transcription, initiation
Xcom_RS15300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Xcom_RS15305	COG0251	oxidation-reduction process
Xcom_RS15315	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Xcom_RS15315	COG0392	lysyltransferase activity
Xcom_RS15350	COG2814	Major facilitator Superfamily
Xcom_RS15355	COG1902	pentaerythritol trinitrate reductase activity
Xcom_RS15365	COG2824	Alkylphosphonate utilization operon protein PhnA
Xcom_RS15375	COG1047	Peptidyl-prolyl cis-trans
Xcom_RS15400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Xcom_RS15410	COG5487	UPF0391 membrane protein
Xcom_RS15415	COG1451	nucleotide metabolic process
Xcom_RS15440	COG0183	Belongs to the thiolase family
Xcom_RS15480	COG1793	dna ligase
Xcom_RS15480	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Xcom_RS15490	COG1793	dna ligase
Xcom_RS15495	COG1201	RNA secondary structure unwinding
Xcom_RS15505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Xcom_RS15510	COG1278	Cold shock
Xcom_RS15520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Xcom_RS15525	COG1472	Belongs to the glycosyl hydrolase 3 family
Xcom_RS15530	COG3046	protein related to deoxyribodipyrimidine photolyase
Xcom_RS15535	COG1233	COG1233 Phytoene dehydrogenase and related
Xcom_RS15540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Xcom_RS15545	COG2954	triphosphatase activity
Xcom_RS15550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Xcom_RS15565	COG1381	Involved in DNA repair and RecF pathway recombination
Xcom_RS15575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Xcom_RS15580	COG0571	ribonuclease III activity
Xcom_RS15595	COG0481	GTPase activity
Xcom_RS15600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Xcom_RS15615	COG1250	3-hydroxyacyl-CoA dehydrogenase
Xcom_RS15615	COG1024	Enoyl-CoA hydratase
Xcom_RS15640	COG1024	Enoyl-CoA hydratase
Xcom_RS15645	COG1960	acyl-CoA dehydrogenase activity
Xcom_RS15665	COG3867	Arabinogalactan endo-beta-1,4-galactanase
Xcom_RS15670	COG3250	beta-galactosidase activity
Xcom_RS15690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Xcom_RS15700	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Xcom_RS15720	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Xcom_RS15720	COG3291	Pkd domain containing protein
Xcom_RS15740	COG0606	chelatase, subunit chli
Xcom_RS15755	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Xcom_RS15795	COG1690	Belongs to the RtcB family
Xcom_RS15830	COG1090	epimerase
Xcom_RS15840	COG0642	Histidine kinase
Xcom_RS15860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Xcom_RS15885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Xcom_RS15890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Xcom_RS15905	COG0753	catalase activity
Xcom_RS15920	COG2197	response regulator
Xcom_RS15925	COG4585	Histidine kinase
Xcom_RS15930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_RS15935	COG1136	(ABC) transporter
Xcom_RS15960	COG0697	spore germination
Xcom_RS15980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xcom_RS15985	COG0180	Tryptophanyl-tRNA synthetase
Xcom_RS15990	COG3237	CsbD-like
Xcom_RS16035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Xcom_RS16050	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Xcom_RS16055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Xcom_RS16055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Xcom_RS16100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Xcom_RS16135	COG1199	ATP-dependent helicase activity
Xcom_RS16150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Xcom_RS16200	COG0625	glutathione transferase activity
Xcom_RS16235	COG4555	ABC transporter
Xcom_RS16245	COG1476	TRANSCRIPTIONal
Xcom_RS16270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Xcom_RS16275	COG1131	(ABC) transporter
Xcom_RS16280	COG0842	Transport permease protein
Xcom_RS16285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Xcom_RS16315	COG1309	transcriptional regulator
Xcom_RS16320	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS16325	COG0308	aminopeptidase N
Xcom_RS16330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Xcom_RS16340	COG0330	HflC and HflK could
Xcom_RS16345	COG0330	HflC and HflK could
Xcom_RS16365	COG0678	peroxiredoxin activity
Xcom_RS16375	COG4953	penicillin-binding protein 1C
Xcom_RS16395	COG2373	Large extracellular alpha-helical protein
Xcom_RS16440	COG3829	transcription factor binding
Xcom_RS16470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Xcom_RS16475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Xcom_RS16505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xcom_RS16510	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Xcom_RS16515	COG1399	metal-binding, possibly nucleic acid-binding protein
Xcom_RS16520	COG0424	maF-like protein
Xcom_RS16530	COG0714	Associated with various cellular activities
Xcom_RS16550	COG0537	adenosine 5'-monophosphoramidase activity
Xcom_RS16555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Xcom_RS16560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Xcom_RS16605	COG0314	molybdopterin synthase activity
Xcom_RS16610	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Xcom_RS16615	COG0315	cyclic pyranopterin monophosphate synthase activity
Xcom_RS16625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Xcom_RS16630	COG1234	tRNA 3'-trailer cleavage
Xcom_RS16635	COG3642	lipopolysaccharide core region biosynthetic process
Xcom_RS16640	COG0859	PFAM glycosyl transferase family 9
Xcom_RS16655	COG0631	protein serine/threonine phosphatase activity
Xcom_RS16660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Xcom_RS16665	COG0328	RNA-DNA hybrid ribonuclease activity
Xcom_RS16675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xcom_RS16685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Xcom_RS16710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Xcom_RS16720	COG0544	peptidyl-prolyl cis-trans isomerase activity
Xcom_RS16760	COG0473	3-isopropylmalate dehydrogenase activity
Xcom_RS16775	COG4783	chaperone-mediated protein folding
Xcom_RS16790	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Xcom_RS16800	COG0438	transferase activity, transferring glycosyl groups
Xcom_RS16805	COG0671	phosphoesterase, PA-phosphatase related
Xcom_RS16810	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Xcom_RS16820	COG3291	Pkd domain containing protein
Xcom_RS16825	COG2833	Protein of unknown function (DUF455)
Xcom_RS16850	COG0285	dihydrofolate synthase activity
Xcom_RS16855	COG0406	alpha-ribazole phosphatase activity
Xcom_RS16880	COG1063	alcohol dehydrogenase
Xcom_RS16895	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Xcom_RS16900	COG4208	sulfate ABC transporter
Xcom_RS16905	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Xcom_RS16910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Xcom_RS16915	COG0156	8-amino-7-oxononanoate synthase activity
Xcom_RS16935	COG2885	chlorophyll binding
Xcom_RS16940	COG0604	alcohol dehydrogenase
Xcom_RS16945	COG0446	pyridine nucleotide-disulphide oxidoreductase
Xcom_RS16945	COG1902	pentaerythritol trinitrate reductase activity
Xcom_RS16965	COG0625	glutathione transferase activity
Xcom_RS16970	COG0039	L-malate dehydrogenase activity
Xcom_RS16975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Xcom_RS16980	COG1217	gtp-binding protein TYPA
Xcom_RS16990	COG0154	amidase activity
Xcom_RS17000	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Xcom_RS17020	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Xcom_RS17025	COG0203	ribosomal protein L17
Xcom_RS17050	COG0201	protein transport
Xcom_RS17055	COG0200	Binds to the 23S rRNA
Xcom_RS17060	COG1841	ribosomal large subunit assembly
Xcom_RS17070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Xcom_RS17075	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Xcom_RS17080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Xcom_RS17085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Xcom_RS17090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Xcom_RS17105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Xcom_RS17110	COG0255	Belongs to the universal ribosomal protein uL29 family
Xcom_RS17115	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Xcom_RS17120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Xcom_RS17130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Xcom_RS17135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Xcom_RS17145	COG0088	Forms part of the polypeptide exit tunnel
Xcom_RS17150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Xcom_RS17155	COG0051	transcription antitermination factor activity, RNA binding
Xcom_RS17170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Xcom_RS17175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Xcom_RS17180	COG0049	tRNA binding
Xcom_RS17185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Xcom_RS17190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Xcom_RS17195	COG0085	RNA polymerase activity
Xcom_RS17200	COG0222	ribosome binding
Xcom_RS17205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Xcom_RS17210	COG0081	regulation of translation
Xcom_RS17215	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Xcom_RS17220	COG0250	Participates in transcription elongation, termination and antitermination
Xcom_RS17235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Xcom_RS17255	COG0012	GTP binding
Xcom_RS17260	COG0193	aminoacyl-tRNA hydrolase activity
Xcom_RS17265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Xcom_RS17270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Xcom_RS17280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Xcom_RS17285	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Xcom_RS17295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Xcom_RS17300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Xcom_RS17310	COG0521	Mo-molybdopterin cofactor biosynthetic process
Xcom_RS17325	COG1254	Belongs to the acylphosphatase family
Xcom_RS17330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Xcom_RS17335	COG1295	ribonuclease BN
Xcom_RS17360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Xcom_RS17365	COG1404	Belongs to the peptidase S8 family
Xcom_RS17370	COG1404	Belongs to the peptidase S8 family
Xcom_RS17375	COG1404	Belongs to the peptidase S8 family
Xcom_RS17380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Xcom_RS17420	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Xcom_RS17440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Xcom_RS17440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Xcom_RS17460	COG2890	protein-(glutamine-N5) methyltransferase activity
Xcom_RS17470	COG3634	alkyl hydroperoxide reductase activity
Xcom_RS17475	COG0583	DNA-binding transcription factor activity
Xcom_RS17485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Xcom_RS17490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Xcom_RS17505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Xcom_RS17515	COG2197	response regulator
Xcom_RS17525	COG0745	RESPONSE REGULATOR receiver
Xcom_RS17540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Xcom_RS17550	COG0697	spore germination
Xcom_RS17570	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Xcom_RS17580	COG3386	PFAM SMP-30 Gluconolaconase
Xcom_RS17600	COG1024	Enoyl-CoA hydratase
Xcom_RS17610	COG0318	PFAM AMP-dependent synthetase and ligase
Xcom_RS17615	COG0583	DNA-binding transcription factor activity
Xcom_RS17620	COG3384	dioxygenase
Xcom_RS17650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Xcom_RS17655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Xcom_RS17670	COG2096	Adenosyltransferase
Xcom_RS17675	COG0123	including yeast histone deacetylase and acetoin utilization protein
Xcom_RS17680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Xcom_RS17685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Xcom_RS17690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Xcom_RS17695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Xcom_RS17700	COG2967	ApaG domain
Xcom_RS17705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Xcom_RS17720	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Xcom_RS17725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Xcom_RS17745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Xcom_RS17770	COG4181	ATPase activity
Xcom_RS17780	COG2175	clavaminate synthase activity
Xcom_RS17790	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Xcom_RS17795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Xcom_RS17815	COG4771	TonB-dependent receptor
Xcom_RS17825	COG0667	Aldo Keto reductase
Xcom_RS17830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Xcom_RS17835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Xcom_RS17845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Xcom_RS17850	COG4106	trans-aconitate 2-methyltransferase activity
Xcom_RS17860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Xcom_RS17900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Xcom_RS17910	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Xcom_RS17915	COG2226	methyltransferase
Xcom_RS17945	COG0366	Alpha amylase catalytic
Xcom_RS17970	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS17970	COG0604	alcohol dehydrogenase
Xcom_RS17970	COG3321	synthase
Xcom_RS17980	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Xcom_RS17990	COG0494	nUDIX hydrolase
Xcom_RS18000	COG0653	protein targeting
Xcom_RS18005	COG0739	heme binding
Xcom_RS18015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Xcom_RS18030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Xcom_RS18035	COG1181	Belongs to the D-alanine--D-alanine ligase family
Xcom_RS18040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Xcom_RS18045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Xcom_RS18055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Xcom_RS18060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Xcom_RS18065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Xcom_RS18080	COG3116	cell division
Xcom_RS18085	COG0275	rRNA processing
Xcom_RS18125	COG0792	nuclease activity
Xcom_RS18130	COG1988	membrane-bound metal-dependent
Xcom_RS18135	COG0277	FAD linked oxidase domain protein
Xcom_RS18145	COG0745	RESPONSE REGULATOR receiver
Xcom_RS18150	COG2205	protein histidine kinase activity
Xcom_RS18160	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Xcom_RS18165	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Xcom_RS18190	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Xcom_RS18195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Xcom_RS18200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Xcom_RS18220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Xcom_RS18220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Xcom_RS18230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Xcom_RS18235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Xcom_RS18245	COG0488	(ABC) transporter
Xcom_RS18260	COG3791	Glutathione-dependent formaldehyde-activating
Xcom_RS18290	COG2205	protein histidine kinase activity
Xcom_RS18300	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Xcom_RS18330	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Xcom_RS18335	COG1012	belongs to the aldehyde dehydrogenase family
Xcom_RS18340	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Xcom_RS18345	COG0617	tRNA 3'-terminal CCA addition
Xcom_RS18360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Xcom_RS18365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Xcom_RS18370	COG1609	Transcriptional regulator
Xcom_RS18380	COG2188	Transcriptional regulator
Xcom_RS18405	COG4795	General secretion pathway protein
Xcom_RS18425	COG1459	type II secretion system
Xcom_RS18480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Xcom_RS18485	COG4191	Histidine kinase
Xcom_RS18490	COG0784	Response regulator, receiver
Xcom_RS18495	COG4251	negative regulation of phosphorylation
Xcom_RS18500	COG2823	Periplasmic or secreted lipoprotein
Xcom_RS18505	COG0673	inositol 2-dehydrogenase activity
Xcom_RS18510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Xcom_RS18545	COG1051	belongs to the nudix hydrolase family
Xcom_RS18545	COG1056	cytidyltransferase-related domain
Xcom_RS18555	COG0583	DNA-binding transcription factor activity
Xcom_RS18570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Xcom_RS18575	COG0321	lipoyl(octanoyl) transferase activity
Xcom_RS18580	COG2921	Belongs to the UPF0250 family
Xcom_RS18595	COG1686	Belongs to the peptidase S11 family
Xcom_RS18605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Xcom_RS18610	COG2951	lytic endotransglycosylase activity
Xcom_RS18625	COG0772	Belongs to the SEDS family
Xcom_RS18640	COG1792	Involved in formation and maintenance of cell shape
Xcom_RS18645	COG1077	Cell shape determining protein MreB Mrl
Xcom_RS18650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Xcom_RS18655	COG3284	Transcriptional regulator
Xcom_RS18665	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Xcom_RS18705	COG0308	aminopeptidase N
Xcom_RS18710	COG3300	MHYT domain
Xcom_RS18710	COG5001	Diguanylate cyclase
Xcom_RS18740	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Xcom_RS18745	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Xcom_RS18750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Xcom_RS18760	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Xcom_RS18770	COG2832	Protein of unknown function (DUF454)
Xcom_RS18785	COG0436	Aminotransferase
Xcom_RS18790	COG1505	serine-type exopeptidase activity
Xcom_RS18830	COG0181	hydroxymethylbilane synthase activity
Xcom_RS18840	COG3275	phosphorelay sensor kinase activity
Xcom_RS18850	COG2943	transferase activity, transferring hexosyl groups
Xcom_RS18875	COG0659	secondary active sulfate transmembrane transporter activity
Xcom_RS18880	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xcom_RS18880	COG5297	Belongs to the glycosyl hydrolase family 6
Xcom_RS18885	COG0840	transmembrane signaling receptor activity
Xcom_RS18930	COG2801	Transposase and inactivated derivatives
Xcom_RS18940	COG0598	Magnesium transport protein CorA
Xcom_RS18950	COG1113	amino acid transport
Xcom_RS18970	COG0697	spore germination
Xcom_RS18995	COG1959	2 iron, 2 sulfur cluster binding
Xcom_RS19025	COG2409	Drug exporters of the RND superfamily
Xcom_RS19050	COG0435	Glutathione S-transferase
Xcom_RS19060	COG4221	oxidoreductase activity
Xcom_RS19100	COG4221	oxidoreductase activity
Xcom_RS19165	COG0546	phosphoglycolate phosphatase activity
Xcom_RS19170	COG1802	Transcriptional regulator
Xcom_RS19180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Xcom_RS19205	COG3052	prosthetic group binding
Xcom_RS19235	COG2353	YceI-like domain
Xcom_RS19240	COG0778	Nitroreductase
Xcom_RS19265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Xcom_RS19270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Xcom_RS19280	COG3386	PFAM SMP-30 Gluconolaconase
Xcom_RS19295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Xcom_RS19310	COG0459	protein refolding
Xcom_RS19325	COG2356	endonuclease I
Xcom_RS19335	COG1324	tolerance protein
Xcom_RS19345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Xcom_RS19350	COG0511	ligase activity, forming carbon-carbon bonds
Xcom_RS19360	COG0439	Biotin carboxylase
Xcom_RS19385	COG2264	protein methyltransferase activity
Xcom_RS19415	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Xcom_RS19420	COG4589	Belongs to the CDS family
Xcom_RS19445	COG2453	phosphatase
Xcom_RS19445	COG0671	phosphoesterase, PA-phosphatase related
Xcom_RS19450	COG2267	carboxylic ester hydrolase activity
Xcom_RS19455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Xcom_RS19460	COG0138	bifunctional purine biosynthesis protein purh
Xcom_RS19470	COG0151	Belongs to the GarS family
Xcom_RS19475	COG1289	transmembrane transporter activity
Xcom_RS19480	COG2814	Major facilitator Superfamily
Xcom_RS19490	COG2814	Major facilitator Superfamily
Xcom_RS19510	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Xcom_RS19530	COG0316	Belongs to the HesB IscA family
Xcom_RS19575	COG1051	belongs to the nudix hydrolase family
Xcom_RS19590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Xcom_RS19600	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Xcom_RS19610	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Xcom_RS19615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Xcom_RS19625	COG0134	indole-3-glycerol-phosphate synthase activity
Xcom_RS19630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Xcom_RS19660	COG1597	lipid kinase activity
Xcom_RS19665	COG0456	acetyltransferase
Xcom_RS19675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Xcom_RS19680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Xcom_RS19700	COG3179	chitinase
Xcom_RS19725	COG2111	Na H antiporter
Xcom_RS19725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Xcom_RS19730	COG1006	Multisubunit Na H antiporter MnhC subunit
Xcom_RS19735	COG0651	ATP synthesis coupled electron transport
Xcom_RS19745	COG2212	antiporter activity
Xcom_RS19750	COG1320	monovalent cation:proton antiporter activity
Xcom_RS19765	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
Xcom_RS19770	COG2852	Protein conserved in bacteria
Xcom_RS19790	COG3104	oligopeptide transport
Xcom_RS19795	COG3483	tryptophan 2,3-dioxygenase activity
Xcom_RS19805	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Xcom_RS19820	COG0508	dehydrogenase complex catalyzes the overall conversion of
Xcom_RS19840	COG0513	Belongs to the DEAD box helicase family
Xcom_RS19855	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS19860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xcom_RS19895	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS19900	COG0702	epimerase
Xcom_RS19925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Xcom_RS19930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Xcom_RS19935	COG0297	glycogen (starch) synthase activity
Xcom_RS19945	COG2354	Protein conserved in bacteria
Xcom_RS19955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Xcom_RS19965	COG1368	sulfuric ester hydrolase activity
Xcom_RS19970	COG1511	domain protein
Xcom_RS19970	COG3264	Mechanosensitive ion channel
Xcom_RS20040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Xcom_RS20100	COG2801	Transposase and inactivated derivatives
Xcom_RS20130	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Xcom_RS20140	COG1040	competence protein
Xcom_RS20145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Xcom_RS20150	COG0156	8-amino-7-oxononanoate synthase activity
Xcom_RS20160	COG2267	carboxylic ester hydrolase activity
Xcom_RS20165	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS20190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Xcom_RS20205	COG0445	tRNA wobble uridine modification
Xcom_RS20215	COG0657	acetylesterase activity
Xcom_RS20225	COG1414	Transcriptional regulator
Xcom_RS20240	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Xcom_RS20245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Xcom_RS20255	COG3485	protocatechuate 3,4-dioxygenase
Xcom_RS20260	COG3485	protocatechuate 3,4-dioxygenase
Xcom_RS20270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Xcom_RS20275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Xcom_RS20300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Xcom_RS20305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Xcom_RS20355	COG0129	dihydroxy-acid dehydratase activity
Xcom_RS20370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Xcom_RS20415	COG1733	regulation of RNA biosynthetic process
Xcom_RS20420	COG0702	epimerase
Xcom_RS20460	COG0583	DNA-binding transcription factor activity
Xcom_RS20465	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Xcom_RS20490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_RS20495	COG2205	protein histidine kinase activity
Xcom_RS20500	COG0745	RESPONSE REGULATOR receiver
Xcom_RS20520	COG1902	pentaerythritol trinitrate reductase activity
Xcom_RS20525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Xcom_RS20530	COG2267	carboxylic ester hydrolase activity
Xcom_RS20540	COG2814	Major facilitator Superfamily
Xcom_RS20545	COG0583	DNA-binding transcription factor activity
Xcom_RS20560	COG0084	hydrolase, TatD family'
Xcom_RS20585	COG2252	PERMEase
Xcom_RS20630	COG0583	DNA-binding transcription factor activity
Xcom_RS20640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Xcom_RS20660	COG2072	flavoprotein involved in K transport
Xcom_RS20665	COG2351	hydroxyisourate hydrolase activity
Xcom_RS20670	COG4807	Protein conserved in bacteria
Xcom_RS20680	COG1643	Atp-dependent helicase
Xcom_RS20690	COG1187	pseudouridine synthase activity
Xcom_RS20705	COG2130	NADP-dependent
Xcom_RS20725	COG1764	response to oxidative stress
Xcom_RS20730	COG1846	Transcriptional regulator
Xcom_RS20735	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Xcom_RS20745	COG0697	spore germination
Xcom_RS20760	COG0523	cobalamin synthesis protein
Xcom_RS20815	COG1960	acyl-CoA dehydrogenase activity
Xcom_RS20820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Xcom_RS20825	COG4770	biotin carboxylase activity
Xcom_RS20855	COG2224	Isocitrate lyase
Xcom_RS20860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Xcom_RS20865	COG0583	DNA-binding transcription factor activity
Xcom_RS20870	COG0475	glutathione-regulated potassium exporter activity
Xcom_RS20925	COG0564	pseudouridine synthase activity
Xcom_RS20965	COG1309	transcriptional regulator
Xcom_RS20975	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_RS21030	COG1074	ATP-dependent DNA helicase activity
Xcom_RS21035	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Xcom_RS21070	COG1127	ABC transporter
Xcom_RS21075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Xcom_RS21080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Xcom_RS21095	COG2853	Lipoprotein
Xcom_RS21105	COG0386	Belongs to the glutathione peroxidase family
Xcom_RS21115	COG1322	Protein conserved in bacteria
Xcom_RS21120	COG0604	alcohol dehydrogenase
Xcom_RS21150	COG0531	amino acid
Xcom_RS21155	COG3537	Alpha-1,2-mannosidase
Xcom_RS21170	COG2203	Gaf domain
Xcom_RS21170	COG2199	diguanylate cyclase activity
Xcom_RS21175	COG3835	regulator
Xcom_RS21180	COG1929	Belongs to the glycerate kinase type-1 family
Xcom_RS21185	COG2271	Major facilitator Superfamily
Xcom_RS21200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Xcom_RS21210	COG0861	Integral membrane protein TerC family
Xcom_RS21225	COG0584	glycerophosphoryl diester phosphodiesterase
Xcom_RS21245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Xcom_RS21250	COG0726	polysaccharide deacetylase
Xcom_RS21255	COG0706	membrane insertase activity
Xcom_RS21260	COG0594	ribonuclease P activity
Xcom_RS21280	COG2951	lytic endotransglycosylase activity
Xcom_RS21435	COG0489	protein tyrosine kinase activity