locus-tag	class	description
XAV_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XAV_RS00020	COG0187	DNA topoisomerase II activity
XAV_RS00030	COG0501	Belongs to the peptidase M48B family
XAV_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XAV_RS00120	COG0793	Belongs to the peptidase S41A family
XAV_RS00125	COG4942	peptidase
XAV_RS00135	COG2234	aminopeptidase activity
XAV_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAV_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAV_RS00165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAV_RS00170	COG1064	alcohol dehydrogenase
XAV_RS00200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAV_RS00250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XAV_RS00255	COG1902	pentaerythritol trinitrate reductase activity
XAV_RS00300	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XAV_RS00305	COG0583	DNA-binding transcription factor activity
XAV_RS00340	COG0702	epimerase
XAV_RS00345	COG1733	regulation of RNA biosynthetic process
XAV_RS00375	COG0129	dihydroxy-acid dehydratase activity
XAV_RS00390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XAV_RS00420	COG3039	Transposase
XAV_RS00465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XAV_RS00470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XAV_RS00500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XAV_RS00510	COG3485	protocatechuate 3,4-dioxygenase
XAV_RS00515	COG3485	protocatechuate 3,4-dioxygenase
XAV_RS00525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAV_RS00530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XAV_RS00565	COG0493	'glutamate synthase
XAV_RS00570	COG0067	glutamate synthase
XAV_RS00570	COG0069	glutamate synthase activity
XAV_RS00570	COG0070	glutamate synthase
XAV_RS00605	COG2937	Belongs to the GPAT DAPAT family
XAV_RS00635	COG0284	orotidine-5'-phosphate decarboxylase activity
XAV_RS00640	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XAV_RS00645	COG3132	Protein of unknown function, DUF480
XAV_RS00665	COG0210	DNA helicase
XAV_RS00670	COG1435	thymidine kinase activity
XAV_RS00680	COG3039	Transposase
XAV_RS00715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XAV_RS00740	COG1304	FMN binding
XAV_RS00780	COG4772	TonB-dependent receptor
XAV_RS00790	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XAV_RS00850	COG2211	Major facilitator Superfamily
XAV_RS00865	COG3693	PFAM glycoside hydrolase, family 10
XAV_RS00870	COG3693	PFAM glycoside hydrolase, family 10
XAV_RS00900	COG3039	Transposase
XAV_RS00925	COG1472	Belongs to the glycosyl hydrolase 3 family
XAV_RS00930	COG3507	Belongs to the glycosyl hydrolase 43 family
XAV_RS00945	COG3661	Belongs to the glycosyl hydrolase 67 family
XAV_RS00955	COG2115	Belongs to the xylose isomerase family
XAV_RS00960	COG0037	tRNA processing
XAV_RS00965	COG2974	May be involved in recombination
XAV_RS00980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XAV_RS00990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XAV_RS00995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XAV_RS01000	COG0805	protein transport
XAV_RS01010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XAV_RS01010	COG0519	Catalyzes the synthesis of GMP from XMP
XAV_RS01020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XAV_RS01035	COG0457	Tetratricopeptide repeat
XAV_RS01040	COG4771	TonB-dependent receptor
XAV_RS01045	COG0729	surface antigen
XAV_RS01050	COG2911	Protein conserved in bacteria
XAV_RS01060	COG0443	Heat shock 70 kDa protein
XAV_RS01085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAV_RS01090	COG3265	gluconokinase activity
XAV_RS01095	COG2211	Major facilitator Superfamily
XAV_RS01100	COG3459	Glycosyltransferase 36 associated
XAV_RS01110	COG2205	protein histidine kinase activity
XAV_RS01115	COG1971	Probably functions as a manganese efflux pump
XAV_RS01125	COG2207	Transcriptional regulator
XAV_RS01125	COG1917	Cupin 2, conserved barrel domain protein
XAV_RS01130	COG1414	Transcriptional regulator
XAV_RS01150	COG0179	Fumarylacetoacetate (FAA) hydrolase
XAV_RS01195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XAV_RS01210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XAV_RS01215	COG0708	Exodeoxyribonuclease III
XAV_RS01230	COG2091	lysine biosynthetic process via aminoadipic acid
XAV_RS01240	COG3540	Alkaline phosphatase
XAV_RS01245	COG0357	Ribosomal RNA small subunit methyltransferase G
XAV_RS01290	COG2159	amidohydrolase
XAV_RS01300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XAV_RS01310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAV_RS01325	COG0210	DNA helicase
XAV_RS01375	COG2814	Major facilitator Superfamily
XAV_RS01415	COG1272	protein, Hemolysin III
XAV_RS01420	COG1111	helicase
XAV_RS01420	COG1205	dead DEAH box helicase
XAV_RS01485	COG1414	Transcriptional regulator
XAV_RS01500	COG0445	tRNA wobble uridine modification
XAV_RS01540	COG2267	carboxylic ester hydrolase activity
XAV_RS01550	COG0156	8-amino-7-oxononanoate synthase activity
XAV_RS01555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XAV_RS01560	COG1040	competence protein
XAV_RS01565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XAV_RS01650	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XAV_RS01710	COG3039	Transposase
XAV_RS01720	COG1511	domain protein
XAV_RS01720	COG3264	Mechanosensitive ion channel
XAV_RS01730	COG3039	Transposase
XAV_RS01780	COG3210	domain, Protein
XAV_RS01785	COG2831	hemolysin activation secretion protein
XAV_RS01815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XAV_RS01820	COG2354	Protein conserved in bacteria
XAV_RS01840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAV_RS01845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAV_RS01870	COG0702	epimerase
XAV_RS01885	COG1858	cytochrome C peroxidase
XAV_RS01940	COG3039	Transposase
XAV_RS01995	COG0513	Belongs to the DEAD box helicase family
XAV_RS02025	COG3483	tryptophan 2,3-dioxygenase activity
XAV_RS02030	COG3104	oligopeptide transport
XAV_RS02050	COG2852	Protein conserved in bacteria
XAV_RS02055	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XAV_RS02075	COG1320	monovalent cation:proton antiporter activity
XAV_RS02080	COG2212	antiporter activity
XAV_RS02090	COG0651	ATP synthesis coupled electron transport
XAV_RS02095	COG1006	Multisubunit Na H antiporter MnhC subunit
XAV_RS02100	COG2111	Na H antiporter
XAV_RS02100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XAV_RS02135	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XAV_RS02155	COG1597	lipid kinase activity
XAV_RS02175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XAV_RS02210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XAV_RS02215	COG0134	indole-3-glycerol-phosphate synthase activity
XAV_RS02225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAV_RS02230	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XAV_RS02240	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XAV_RS02250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XAV_RS02265	COG1051	belongs to the nudix hydrolase family
XAV_RS02305	COG0316	Belongs to the HesB IscA family
XAV_RS02320	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XAV_RS02335	COG2814	Major facilitator Superfamily
XAV_RS02345	COG2814	Major facilitator Superfamily
XAV_RS02350	COG1289	transmembrane transporter activity
XAV_RS02370	COG1136	(ABC) transporter
XAV_RS02370	COG0577	efflux transmembrane transporter activity
XAV_RS02375	COG0151	Belongs to the GarS family
XAV_RS02380	COG0138	bifunctional purine biosynthesis protein purh
XAV_RS02395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XAV_RS02415	COG2264	protein methyltransferase activity
XAV_RS02430	COG0439	Biotin carboxylase
XAV_RS02440	COG0511	ligase activity, forming carbon-carbon bonds
XAV_RS02445	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XAV_RS02460	COG1324	tolerance protein
XAV_RS02475	COG0459	protein refolding
XAV_RS02495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XAV_RS02510	COG3386	PFAM SMP-30 Gluconolaconase
XAV_RS02520	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XAV_RS02565	COG0778	Nitroreductase
XAV_RS02570	COG2353	YceI-like domain
XAV_RS02595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XAV_RS02670	COG2375	cellular response to nickel ion
XAV_RS02725	COG1063	alcohol dehydrogenase
XAV_RS02755	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_RS02775	COG1271	oxidase subunit
XAV_RS02785	COG2204	response regulator
XAV_RS02820	COG3546	catalase activity
XAV_RS02825	COG3685	Protein conserved in bacteria
XAV_RS02855	COG0531	amino acid
XAV_RS02875	COG3590	peptidase
XAV_RS02885	COG0667	Aldo Keto reductase
XAV_RS02905	COG3384	dioxygenase
XAV_RS02915	COG1573	uracil-dna glycosylase
XAV_RS02920	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XAV_RS02925	COG0025	NhaP-type Na H and K H
XAV_RS02930	COG1131	(ABC) transporter
XAV_RS02935	COG0842	Transport permease protein
XAV_RS02990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAV_RS02995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XAV_RS03015	COG2205	protein histidine kinase activity
XAV_RS03015	COG2202	Pas domain
XAV_RS03035	COG2813	Specifically methylates the guanine in position
XAV_RS03040	COG1187	pseudouridine synthase activity
XAV_RS03045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XAV_RS03080	COG1666	GTP binding
XAV_RS03085	COG0697	spore germination
XAV_RS03090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XAV_RS03095	COG2011	ABC-type metal ion transport system permease component
XAV_RS03130	COG0508	dehydrogenase complex catalyzes the overall conversion of
XAV_RS03140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XAV_RS03160	COG0356	it plays a direct role in the translocation of protons across the membrane
XAV_RS03175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XAV_RS03180	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XAV_RS03185	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XAV_RS03190	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XAV_RS03195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XAV_RS03210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XAV_RS03225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XAV_RS03275	COG2132	Multicopper oxidase
XAV_RS03290	COG0339	signal peptide processing
XAV_RS03310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAV_RS03315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XAV_RS03330	COG1956	GAF domain-containing protein
XAV_RS03335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XAV_RS03345	COG0720	synthase
XAV_RS03350	COG0513	Belongs to the DEAD box helicase family
XAV_RS03390	COG0626	cystathionine gamma-synthase activity
XAV_RS03410	COG1216	Glycosyl transferase, family 2
XAV_RS03410	COG0438	transferase activity, transferring glycosyl groups
XAV_RS03450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAV_RS03465	COG0277	FAD linked oxidase domain protein
XAV_RS03470	COG0546	phosphoglycolate phosphatase activity
XAV_RS03470	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XAV_RS03485	COG2086	electron transfer activity
XAV_RS03515	COG0662	Cupin 2, conserved barrel domain protein
XAV_RS03515	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XAV_RS03520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XAV_RS03555	COG3218	ABC-type transport auxiliary lipoprotein component
XAV_RS03555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XAV_RS03560	COG1127	ABC transporter
XAV_RS03565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XAV_RS03580	COG0442	prolyl-tRNA aminoacylation
XAV_RS03590	COG1183	phosphatidylcholine synthase activity
XAV_RS03625	COG0525	valine-tRNA ligase activity
XAV_RS03645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XAV_RS03655	COG0795	lipopolysaccharide-transporting ATPase activity
XAV_RS03670	COG4974	Belongs to the 'phage' integrase family
XAV_RS03695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XAV_RS03700	COG0047	phosphoribosylformylglycinamidine synthase activity
XAV_RS03700	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XAV_RS03710	COG5295	Hep Hag repeat protein
XAV_RS03715	COG1404	Belongs to the peptidase S8 family
XAV_RS03730	COG1404	Belongs to the peptidase S8 family
XAV_RS03735	COG1404	Belongs to the peptidase S8 family
XAV_RS03740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XAV_RS03745	COG1459	type II secretion system
XAV_RS03750	COG2165	general secretion pathway protein
XAV_RS03755	COG4970	Tfp pilus assembly protein FimT
XAV_RS03760	COG2165	general secretion pathway protein
XAV_RS03765	COG4795	General secretion pathway protein
XAV_RS03770	COG3156	type II secretion system protein K
XAV_RS03775	COG3166	PFAM Fimbrial assembly family protein
XAV_RS03790	COG1450	Type ii and iii secretion system protein
XAV_RS03800	COG2188	Transcriptional regulator
XAV_RS03845	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XAV_RS03885	COG0242	peptide deformylase activity
XAV_RS03890	COG1307	EDD domain protein, DegV family
XAV_RS03935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XAV_RS03960	COG1162	GTPase activity
XAV_RS03985	COG2211	Major facilitator Superfamily
XAV_RS03995	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_RS04000	COG2851	Citrate transporter
XAV_RS04015	COG0642	Histidine kinase
XAV_RS04025	COG2197	response regulator
XAV_RS04040	COG0667	Aldo Keto reductase
XAV_RS04045	COG0583	DNA-binding transcription factor activity
XAV_RS04075	COG1301	dicarboxylic acid transport
XAV_RS04080	COG0280	phosphate acetyltransferase
XAV_RS04080	COG0281	malic enzyme
XAV_RS04150	COG1560	Kdo2-lipid A biosynthetic process
XAV_RS04155	COG1519	Transferase
XAV_RS04160	COG1538	Outer membrane efflux protein
XAV_RS04165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XAV_RS04195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XAV_RS04200	COG0066	3-isopropylmalate dehydratase activity
XAV_RS04210	COG0473	3-isopropylmalate dehydrogenase activity
XAV_RS04215	COG4771	TonB-dependent receptor
XAV_RS04220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XAV_RS04240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XAV_RS04250	COG0840	transmembrane signaling receptor activity
XAV_RS04260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XAV_RS04265	COG3710	Transcriptional regulator
XAV_RS04285	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XAV_RS04295	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XAV_RS04350	COG0563	adenylate kinase activity
XAV_RS04355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XAV_RS04365	COG3781	membrane
XAV_RS04370	COG0671	phosphoesterase, PA-phosphatase related
XAV_RS04400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XAV_RS04430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAV_RS04435	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XAV_RS04445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XAV_RS04455	COG0352	thiamine-phosphate diphosphorylase activity
XAV_RS04465	COG2912	Transglutaminase-like superfamily
XAV_RS04475	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XAV_RS04485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XAV_RS04505	COG3079	Belongs to the UPF0149 family
XAV_RS04510	COG0006	proline dipeptidase activity
XAV_RS04520	COG0006	proline dipeptidase activity
XAV_RS04535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XAV_RS04540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XAV_RS04550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XAV_RS04555	COG1561	YicC-like family, N-terminal region
XAV_RS04570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XAV_RS04580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XAV_RS04585	COG1957	nucleoside hydrolase
XAV_RS04605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XAV_RS04635	COG0714	Associated with various cellular activities
XAV_RS04655	COG2304	oxidoreductase activity
XAV_RS04665	COG1301	dicarboxylic acid transport
XAV_RS04670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XAV_RS04675	COG4773	Receptor
XAV_RS04680	COG0739	heme binding
XAV_RS04685	COG1376	ErfK ybiS ycfS ynhG family protein
XAV_RS04760	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XAV_RS04765	COG4149	molybdate abc transporter
XAV_RS04770	COG0725	ABC transporter, periplasmic molybdate-binding protein
XAV_RS04775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAV_RS04775	COG3453	Protein conserved in bacteria
XAV_RS04790	COG3047	cAMP biosynthetic process
XAV_RS04800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XAV_RS04830	COG0126	phosphoglycerate kinase activity
XAV_RS04840	COG0469	pyruvate kinase activity
XAV_RS04845	COG3588	fructose-bisphosphate aldolase
XAV_RS04850	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XAV_RS04890	COG2205	protein histidine kinase activity
XAV_RS04890	COG2198	Histidine kinase
XAV_RS04890	COG0784	Response regulator, receiver
XAV_RS04910	COG0175	sulfate reduction
XAV_RS04915	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XAV_RS04920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XAV_RS04925	COG0175	sulfate reduction
XAV_RS04930	COG0529	Catalyzes the synthesis of activated sulfate
XAV_RS04930	COG2895	sulfate adenylyltransferase (ATP) activity
XAV_RS04940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAV_RS04955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XAV_RS04995	COG1970	mechanosensitive ion channel activity
XAV_RS05015	COG0471	metal ion transport
XAV_RS05015	COG3273	potassium ion transport
XAV_RS05020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XAV_RS05025	COG2022	thiamine diphosphate biosynthetic process
XAV_RS05080	COG0189	ligase activity
XAV_RS05090	COG0745	RESPONSE REGULATOR receiver
XAV_RS05120	COG0237	dephospho-CoA kinase activity
XAV_RS05125	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XAV_RS05160	COG0045	succinate-CoA ligase (ADP-forming) activity
XAV_RS05165	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XAV_RS05180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XAV_RS05180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XAV_RS05190	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAV_RS05195	COG0564	pseudouridine synthase activity
XAV_RS05210	COG3011	Protein conserved in bacteria
XAV_RS05250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XAV_RS05255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XAV_RS05260	COG0537	adenosine 5'-monophosphoramidase activity
XAV_RS05280	COG0714	Associated with various cellular activities
XAV_RS05295	COG0424	maF-like protein
XAV_RS05300	COG1399	metal-binding, possibly nucleic acid-binding protein
XAV_RS05305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XAV_RS05310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAV_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_RS05340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XAV_RS05345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XAV_RS05375	COG3829	transcription factor binding
XAV_RS05435	COG0678	peroxiredoxin activity
XAV_RS05455	COG0330	HflC and HflK could
XAV_RS05460	COG0330	HflC and HflK could
XAV_RS05465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XAV_RS05470	COG0308	aminopeptidase N
XAV_RS05495	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XAV_RS05520	COG1946	Acyl-CoA thioesterase
XAV_RS05525	COG1024	Enoyl-CoA hydratase
XAV_RS05535	COG0824	Thioesterase
XAV_RS05540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XAV_RS05545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XAV_RS05550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XAV_RS05555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XAV_RS05560	COG0268	Binds directly to 16S ribosomal RNA
XAV_RS05570	COG0196	riboflavin kinase activity
XAV_RS05575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XAV_RS05580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XAV_RS05585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XAV_RS05600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XAV_RS05605	COG1845	cytochrome c oxidase, subunit III
XAV_RS05610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XAV_RS05625	COG3152	Membrane
XAV_RS05635	COG2207	Transcriptional regulator
XAV_RS05655	COG1366	Belongs to the anti-sigma-factor antagonist family
XAV_RS05660	COG1366	Belongs to the anti-sigma-factor antagonist family
XAV_RS05665	COG2172	sigma factor antagonist activity
XAV_RS05675	COG2205	protein histidine kinase activity
XAV_RS05695	COG3507	Belongs to the glycosyl hydrolase 43 family
XAV_RS05730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XAV_RS05735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XAV_RS05745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XAV_RS05750	COG0228	four-way junction DNA binding
XAV_RS05755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XAV_RS05760	COG0336	Belongs to the RNA methyltransferase TrmD family
XAV_RS05770	COG0534	Mate efflux family protein
XAV_RS05780	COG3039	Transposase
XAV_RS05805	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XAV_RS05820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XAV_RS05885	COG3039	Transposase
XAV_RS05890	COG3250	beta-galactosidase activity
XAV_RS05895	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XAV_RS05915	COG1960	acyl-CoA dehydrogenase activity
XAV_RS05920	COG1024	Enoyl-CoA hydratase
XAV_RS05940	COG1250	3-hydroxyacyl-CoA dehydrogenase
XAV_RS05940	COG1024	Enoyl-CoA hydratase
XAV_RS05955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XAV_RS05960	COG0481	GTPase activity
XAV_RS05975	COG0571	ribonuclease III activity
XAV_RS05980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XAV_RS05985	COG1381	Involved in DNA repair and RecF pathway recombination
XAV_RS05995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XAV_RS06000	COG2954	triphosphatase activity
XAV_RS06005	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XAV_RS06010	COG1233	COG1233 Phytoene dehydrogenase and related
XAV_RS06015	COG3046	protein related to deoxyribodipyrimidine photolyase
XAV_RS06020	COG1472	Belongs to the glycosyl hydrolase 3 family
XAV_RS06030	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XAV_RS06035	COG1278	Cold shock
XAV_RS06050	COG1201	RNA secondary structure unwinding
XAV_RS06055	COG1793	dna ligase
XAV_RS06065	COG1793	dna ligase
XAV_RS06065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XAV_RS06095	COG0183	Belongs to the thiolase family
XAV_RS06115	COG1451	nucleotide metabolic process
XAV_RS06120	COG5487	UPF0391 membrane protein
XAV_RS06130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XAV_RS06150	COG1047	Peptidyl-prolyl cis-trans
XAV_RS06160	COG2824	Alkylphosphonate utilization operon protein PhnA
XAV_RS06175	COG1902	pentaerythritol trinitrate reductase activity
XAV_RS06180	COG2814	Major facilitator Superfamily
XAV_RS06215	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XAV_RS06215	COG0392	lysyltransferase activity
XAV_RS06225	COG0251	oxidation-reduction process
XAV_RS06230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XAV_RS06270	COG1595	DNA-templated transcription, initiation
XAV_RS06285	COG2878	Part of a membrane complex involved in electron transport
XAV_RS06295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAV_RS06295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAV_RS06315	COG0346	lactoylglutathione lyase activity
XAV_RS06320	COG0833	amino acid
XAV_RS06325	COG2040	homocysteine
XAV_RS06335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XAV_RS06405	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XAV_RS06440	COG1187	pseudouridine synthase activity
XAV_RS06460	COG0514	ATP-dependent DNA helicase (RecQ)
XAV_RS06475	COG0783	Belongs to the Dps family
XAV_RS06480	COG1643	Atp-dependent helicase
XAV_RS06505	COG0535	radical SAM domain protein
XAV_RS06510	COG0535	radical SAM domain protein
XAV_RS06515	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XAV_RS06520	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XAV_RS06530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XAV_RS06540	COG1215	transferase activity, transferring glycosyl groups
XAV_RS06545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XAV_RS06565	COG1199	ATP-dependent helicase activity
XAV_RS06585	COG0189	ligase activity
XAV_RS06600	COG0835	chemotaxis
XAV_RS06605	COG0840	transmembrane signaling receptor activity
XAV_RS06610	COG2198	Histidine kinase
XAV_RS06610	COG0643	Histidine kinase
XAV_RS06610	COG0784	Response regulator, receiver
XAV_RS06635	COG1446	asparaginase
XAV_RS06640	COG3142	Participates in the control of copper homeostasis
XAV_RS06680	COG3537	Alpha-1,2-mannosidase
XAV_RS06730	COG1472	Belongs to the glycosyl hydrolase 3 family
XAV_RS06740	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XAV_RS06745	COG3858	chitin binding
XAV_RS06745	COG1388	LysM domain
XAV_RS06760	COG0837	glucose binding
XAV_RS06775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XAV_RS06785	COG0494	nUDIX hydrolase
XAV_RS06795	COG3956	TIGRFAM MazG family protein
XAV_RS06800	COG1742	UPF0060 membrane protein
XAV_RS06815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XAV_RS06820	COG0509	glycine decarboxylation via glycine cleavage system
XAV_RS06850	COG1960	acyl-CoA dehydrogenase activity
XAV_RS06860	COG1309	transcriptional regulator
XAV_RS06865	COG4771	TonB-dependent receptor
XAV_RS06875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XAV_RS06880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XAV_RS06885	COG0463	Glycosyl transferase, family 2
XAV_RS06900	COG1272	protein, Hemolysin III
XAV_RS06905	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XAV_RS06910	COG0739	heme binding
XAV_RS06915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAV_RS06920	COG0626	cystathionine gamma-synthase activity
XAV_RS06925	COG0460	homoserine dehydrogenase
XAV_RS06925	COG0527	aspartate kinase activity
XAV_RS06935	COG1760	l-serine dehydratase
XAV_RS06955	COG2353	YceI-like domain
XAV_RS06960	COG2205	protein histidine kinase activity
XAV_RS06960	COG2198	Histidine kinase
XAV_RS06960	COG0784	Response regulator, receiver
XAV_RS06985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XAV_RS07000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XAV_RS07005	COG0259	pyridoxamine-phosphate oxidase activity
XAV_RS07015	COG1842	Phage shock protein A
XAV_RS07040	COG0754	glutathionylspermidine amidase activity
XAV_RS07135	COG0531	amino acid
XAV_RS07140	COG2197	response regulator
XAV_RS07145	COG2267	carboxylic ester hydrolase activity
XAV_RS07155	COG1113	amino acid transport
XAV_RS07170	COG1271	oxidase subunit
XAV_RS07175	COG1294	oxidase, subunit
XAV_RS07185	COG2239	Acts as a magnesium transporter
XAV_RS07190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XAV_RS07195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAV_RS07290	COG4651	solute:proton antiporter activity
XAV_RS07290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XAV_RS07320	COG0488	(ABC) transporter
XAV_RS07360	COG0477	Major facilitator Superfamily
XAV_RS07375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XAV_RS07390	COG0217	transcriptional regulatory protein
XAV_RS07395	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XAV_RS07400	COG0632	four-way junction helicase activity
XAV_RS07405	COG3158	transport of potassium into the cell
XAV_RS07415	COG2255	four-way junction helicase activity
XAV_RS07420	COG0824	Thioesterase
XAV_RS07430	COG0848	biopolymer transport protein
XAV_RS07440	COG0823	Involved in the tonB-independent uptake of proteins
XAV_RS07445	COG2885	chlorophyll binding
XAV_RS07455	COG0602	queuosine metabolic process
XAV_RS07495	COG0825	malonyl-CoA metabolic process
XAV_RS07510	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAV_RS07515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAV_RS07520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAV_RS07525	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAV_RS07540	COG0750	zinc metalloprotease
XAV_RS07545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XAV_RS07550	COG0575	Belongs to the CDS family
XAV_RS07555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XAV_RS07560	COG0233	cytoplasmic translational termination
XAV_RS07565	COG0528	UMP kinase activity
XAV_RS07575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XAV_RS07580	COG0052	Belongs to the universal ribosomal protein uS2 family
XAV_RS07620	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XAV_RS07630	COG1393	Belongs to the ArsC family
XAV_RS07640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAV_RS07645	COG0367	asparagine synthase
XAV_RS07655	COG4774	siderophore transport
XAV_RS07695	COG1566	PFAM secretion protein HlyD family protein
XAV_RS07700	COG2814	Major facilitator Superfamily
XAV_RS07775	COG0386	Belongs to the glutathione peroxidase family
XAV_RS07830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XAV_RS07835	COG0084	hydrolase, TatD family'
XAV_RS07865	COG0367	asparagine synthase
XAV_RS07875	COG0305	Participates in initiation and elongation during chromosome replication
XAV_RS07880	COG0415	Belongs to the DNA photolyase family
XAV_RS07910	COG3706	GGDEF domain
XAV_RS07920	COG3706	GGDEF domain
XAV_RS07935	COG3293	Transposase
XAV_RS07955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XAV_RS08005	COG2801	Transposase and inactivated derivatives
XAV_RS08045	COG0582	viral genome integration into host DNA
XAV_RS08060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XAV_RS08075	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAV_RS08085	COG0497	DNA recombination
XAV_RS08090	COG1420	regulation of RNA biosynthetic process
XAV_RS08095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XAV_RS08100	COG0443	Heat shock 70 kDa protein
XAV_RS08105	COG0484	heat shock protein binding
XAV_RS08110	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XAV_RS08145	COG1132	(ABC) transporter
XAV_RS08180	COG2850	peptidyl-arginine hydroxylation
XAV_RS08205	COG1253	flavin adenine dinucleotide binding
XAV_RS08235	COG1131	(ABC) transporter
XAV_RS08240	COG1725	Transcriptional regulator
XAV_RS08245	COG0386	Belongs to the glutathione peroxidase family
XAV_RS08260	COG2900	Belongs to the SlyX family
XAV_RS08285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAV_RS08300	COG0646	methionine synthase
XAV_RS08300	COG1410	methionine synthase
XAV_RS08305	COG2226	methyltransferase
XAV_RS08310	COG1960	acyl-CoA dehydrogenase activity
XAV_RS08325	COG0557	exoribonuclease II activity
XAV_RS08345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XAV_RS08355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XAV_RS08365	COG0704	Plays a role in the regulation of phosphate uptake
XAV_RS08370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XAV_RS08375	COG0581	inorganic phosphate transmembrane transporter activity
XAV_RS08380	COG0573	inorganic phosphate transmembrane transporter activity
XAV_RS08385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XAV_RS08410	COG0659	secondary active sulfate transmembrane transporter activity
XAV_RS08415	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XAV_RS08425	COG1024	Enoyl-CoA hydratase
XAV_RS08435	COG0494	nUDIX hydrolase
XAV_RS08480	COG0116	Belongs to the methyltransferase superfamily
XAV_RS08480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XAV_RS08485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XAV_RS08505	COG0667	Aldo Keto reductase
XAV_RS08515	COG2925	Exonuclease
XAV_RS08520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAV_RS08525	COG3844	kynureninase activity
XAV_RS08535	COG0662	Cupin 2, conserved barrel domain protein
XAV_RS08540	COG0288	reversible hydration of carbon dioxide
XAV_RS08625	COG0017	Asparaginyl-tRNA synthetase
XAV_RS08630	COG0316	Belongs to the HesB IscA family
XAV_RS08635	COG0360	Binds together with S18 to 16S ribosomal RNA
XAV_RS08640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XAV_RS08645	COG0359	binds to the 23S rRNA
XAV_RS08655	COG3115	cell septum assembly
XAV_RS08665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAV_RS08670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XAV_RS08675	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XAV_RS08690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XAV_RS08740	COG3039	Transposase
XAV_RS08755	COG2951	lytic endotransglycosylase activity
XAV_RS08770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XAV_RS08780	COG2986	histidine ammonia-lyase
XAV_RS08785	COG1228	amidohydrolase
XAV_RS08825	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XAV_RS08830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XAV_RS08835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XAV_RS08840	COG1605	Chorismate mutase
XAV_RS08840	COG0077	Prephenate dehydratase
XAV_RS08845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XAV_RS08870	COG0583	DNA-binding transcription factor activity
XAV_RS08885	COG0840	transmembrane signaling receptor activity
XAV_RS08905	COG0784	Response regulator, receiver
XAV_RS08905	COG2205	protein histidine kinase activity
XAV_RS08905	COG5002	protein histidine kinase activity
XAV_RS08910	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XAV_RS08915	COG4191	Histidine kinase
XAV_RS08915	COG0784	Response regulator, receiver
XAV_RS08930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAV_RS08940	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XAV_RS08950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XAV_RS09015	COG2244	polysaccharide biosynthetic process
XAV_RS09040	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
XAV_RS09045	COG2226	methyltransferase
XAV_RS09055	COG0438	transferase activity, transferring glycosyl groups
XAV_RS09070	COG1136	(ABC) transporter
XAV_RS09075	COG1132	(ABC) transporter
XAV_RS09080	COG0477	Major facilitator Superfamily
XAV_RS09085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XAV_RS09100	COG1253	flavin adenine dinucleotide binding
XAV_RS09135	COG0504	CTP synthase activity
XAV_RS09150	COG0148	phosphopyruvate hydratase activity
XAV_RS09155	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XAV_RS09170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XAV_RS09175	COG0585	pseudouridine synthase activity
XAV_RS09180	COG2840	Smr protein MutS2
XAV_RS09185	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XAV_RS09190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XAV_RS09195	COG1238	metal cluster binding
XAV_RS09210	COG1534	Rna-binding protein
XAV_RS09215	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XAV_RS09225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XAV_RS09230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XAV_RS09240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XAV_RS09245	COG1546	Belongs to the CinA family
XAV_RS09255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XAV_RS09260	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XAV_RS09265	COG2137	regulation of response to DNA damage stimulus
XAV_RS09270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XAV_RS09275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XAV_RS09300	COG0784	Response regulator, receiver
XAV_RS09300	COG4191	Histidine kinase
XAV_RS09305	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XAV_RS09310	COG1194	a g-specific adenine glycosylase
XAV_RS09315	COG0552	protein localization to endoplasmic reticulum
XAV_RS09325	COG3938	Belongs to the proline racemase family
XAV_RS09330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAV_RS09345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XAV_RS09355	COG0006	proline dipeptidase activity
XAV_RS09370	COG0531	amino acid
XAV_RS09465	COG3039	Transposase
XAV_RS09485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XAV_RS09490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XAV_RS09495	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XAV_RS09520	COG1472	Belongs to the glycosyl hydrolase 3 family
XAV_RS09530	COG4251	negative regulation of phosphorylation
XAV_RS09530	COG5001	Diguanylate cyclase
XAV_RS09530	COG2203	Gaf domain
XAV_RS09530	COG3706	GGDEF domain
XAV_RS09535	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAV_RS09540	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XAV_RS09550	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XAV_RS09555	COG0671	phosphoesterase, PA-phosphatase related
XAV_RS09570	COG0697	spore germination
XAV_RS09575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XAV_RS09580	COG0167	dihydroorotate dehydrogenase activity
XAV_RS09595	COG1012	belongs to the aldehyde dehydrogenase family
XAV_RS09640	COG2948	multi-organism process
XAV_RS09660	COG3702	type iv secretory pathway
XAV_RS09700	COG3039	Transposase
XAV_RS09710	COG5002	protein histidine kinase activity
XAV_RS09710	COG2205	protein histidine kinase activity
XAV_RS09710	COG0784	Response regulator, receiver
XAV_RS09715	COG2733	membrane
XAV_RS09730	COG2223	nitrite transmembrane transporter activity
XAV_RS09735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XAV_RS09740	COG0243	molybdopterin cofactor binding
XAV_RS09755	COG2703	oxygen carrier activity
XAV_RS09765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAV_RS09770	COG0174	glutamine synthetase
XAV_RS09775	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XAV_RS09800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XAV_RS09820	COG3842	ATPase activity
XAV_RS09825	COG1176	ABC-type spermidine putrescine transport system, permease component I
XAV_RS09830	COG1177	transmembrane transport
XAV_RS09835	COG1012	belongs to the aldehyde dehydrogenase family
XAV_RS09850	COG4535	Mg2 and Co2 transporter CorC
XAV_RS09860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XAV_RS09870	COG1702	phosphate starvation-inducible protein PhoH
XAV_RS09875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XAV_RS09890	COG0741	lytic transglycosylase activity
XAV_RS09895	COG0723	plastoquinol--plastocyanin reductase activity
XAV_RS09900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XAV_RS09905	COG2857	Cytochrome c1
XAV_RS09910	COG0625	glutathione transferase activity
XAV_RS09915	COG2969	positive regulation of protein catabolic process
XAV_RS09940	COG2094	Belongs to the DNA glycosylase MPG family
XAV_RS09950	COG0835	chemotaxis
XAV_RS09970	COG3039	Transposase
XAV_RS09990	COG3039	Transposase
XAV_RS10155	COG3279	Response regulator of the LytR AlgR family
XAV_RS10175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAV_RS10195	COG4566	intracellular signal transduction
XAV_RS10225	COG2154	pterin-4-alpha-carbinolamine dehydratase
XAV_RS10240	COG3064	Membrane
XAV_RS10250	COG1530	ribonuclease E activity
XAV_RS10280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XAV_RS10310	COG1858	cytochrome C peroxidase
XAV_RS10340	COG0515	serine threonine protein kinase
XAV_RS10345	COG0631	protein serine/threonine phosphatase activity
XAV_RS10380	COG3501	Rhs element vgr protein
XAV_RS10505	COG2336	PFAM SpoVT AbrB
XAV_RS10525	COG2003	Belongs to the UPF0758 family
XAV_RS10565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XAV_RS10570	COG0322	excinuclease ABC activity
XAV_RS10580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XAV_RS10585	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XAV_RS10590	COG1663	tetraacyldisaccharide 4'-kinase activity
XAV_RS10595	COG1132	(ABC) transporter
XAV_RS10605	COG0811	peptide transport
XAV_RS10620	COG1136	(ABC) transporter
XAV_RS10625	COG4591	ABC-type transport system involved in lipoprotein release permease component
XAV_RS10635	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XAV_RS10640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XAV_RS10655	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XAV_RS10670	COG0354	folic acid binding
XAV_RS10680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XAV_RS10685	COG0837	glucose binding
XAV_RS10690	COG0363	glucosamine-6-phosphate deaminase activity
XAV_RS10695	COG0129	dihydroxy-acid dehydratase activity
XAV_RS10700	COG0800	Aldolase
XAV_RS10790	COG2183	response to ionizing radiation
XAV_RS10800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAV_RS10800	COG0723	plastoquinol--plastocyanin reductase activity
XAV_RS10815	COG3243	poly(R)-hydroxyalkanoic acid synthase
XAV_RS10825	COG1183	phosphatidylcholine synthase activity
XAV_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_RS10845	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XAV_RS10855	COG0668	transmembrane transport
XAV_RS10860	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XAV_RS10875	COG1914	H( )-stimulated, divalent metal cation uptake system
XAV_RS10925	COG0633	Ferredoxin
XAV_RS10940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XAV_RS10945	COG3002	Belongs to the UPF0753 family
XAV_RS10955	COG0519	Catalyzes the synthesis of GMP from XMP
XAV_RS10955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XAV_RS10965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XAV_RS10980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XAV_RS10995	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XAV_RS11005	COG0776	regulation of translation
XAV_RS11010	COG0539	negative regulation of cytoplasmic translation
XAV_RS11015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XAV_RS11030	COG2957	Belongs to the agmatine deiminase family
XAV_RS11035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XAV_RS11060	COG0395	ABC-type sugar transport system, permease component
XAV_RS11065	COG1175	transmembrane transport
XAV_RS11095	COG2350	Protein conserved in bacteria
XAV_RS11100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XAV_RS11105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XAV_RS11110	COG1187	pseudouridine synthase activity
XAV_RS11135	COG0436	Aminotransferase
XAV_RS11140	COG4133	protoheme IX ABC transporter activity
XAV_RS11160	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XAV_RS11165	COG1138	Cytochrome C-type biogenesis protein
XAV_RS11185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAV_RS11190	COG1278	Cold shock
XAV_RS11195	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XAV_RS11200	COG4988	ABC transporter
XAV_RS11235	COG3609	addiction module antidote protein, CC2985 family
XAV_RS11300	COG3039	Transposase
XAV_RS11305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XAV_RS11325	COG0165	Argininosuccinate lyase
XAV_RS11330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XAV_RS11340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XAV_RS11345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAV_RS11355	COG0137	argininosuccinate synthase activity
XAV_RS11360	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XAV_RS11370	COG0215	cysteine-tRNA ligase activity
XAV_RS11380	COG2166	iron-sulfur cluster assembly
XAV_RS11395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XAV_RS11400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XAV_RS11440	COG4677	pectinesterase activity
XAV_RS11460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XAV_RS11465	COG0402	S-adenosylhomocysteine deaminase activity
XAV_RS11475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XAV_RS11480	COG1509	lysine 2,3-aminomutase activity
XAV_RS11485	COG5001	Diguanylate cyclase
XAV_RS11485	COG3300	MHYT domain
XAV_RS11500	COG0483	inositol monophosphate 1-phosphatase activity
XAV_RS11505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XAV_RS11525	COG0513	Belongs to the DEAD box helicase family
XAV_RS11530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XAV_RS11535	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XAV_RS11545	COG0625	glutathione transferase activity
XAV_RS11555	COG4681	YaeQ
XAV_RS11560	COG2081	HI0933 family
XAV_RS11570	COG0501	Belongs to the peptidase M48B family
XAV_RS11575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAV_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_RS11605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XAV_RS11610	COG0860	N-Acetylmuramoyl-L-alanine amidase
XAV_RS11615	COG0802	atpase or kinase
XAV_RS11620	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XAV_RS11620	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XAV_RS11630	COG1570	exodeoxyribonuclease VII activity
XAV_RS11640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XAV_RS11680	COG3039	Transposase
XAV_RS11710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XAV_RS11710	COG1648	precorrin-2 dehydrogenase activity
XAV_RS11740	COG0303	'Molybdopterin
XAV_RS11760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XAV_RS11765	COG0303	'Molybdopterin
XAV_RS11770	COG1160	GTP binding
XAV_RS11775	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAV_RS11785	COG1426	Protein conserved in bacteria
XAV_RS11795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XAV_RS11810	COG1024	Enoyl-CoA hydratase
XAV_RS11810	COG1250	3-hydroxyacyl-CoA dehydrogenase
XAV_RS11815	COG0183	Belongs to the thiolase family
XAV_RS11820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XAV_RS11825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XAV_RS11835	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XAV_RS11845	COG1674	ftsk spoiiie
XAV_RS11850	COG0492	ferredoxin-NADP+ reductase activity
XAV_RS11870	COG0542	response to heat
XAV_RS11885	COG0482	sulfurtransferase activity
XAV_RS11890	COG2915	High frequency lysogenization protein hflD homolog
XAV_RS11925	COG5002	protein histidine kinase activity
XAV_RS11950	COG0784	Response regulator, receiver
XAV_RS11950	COG0835	chemotaxis
XAV_RS11960	COG1558	bacterial-type flagellum-dependent cell motility
XAV_RS11965	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XAV_RS11975	COG4787	bacterial-type flagellum-dependent cell motility
XAV_RS11985	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XAV_RS11990	COG1706	bacterial-type flagellum-dependent cell motility
XAV_RS11995	COG1705	Flagellar rod assembly protein muramidase FlgJ
XAV_RS11995	COG3951	Flagellar rod assembly protein muramidase FlgJ
XAV_RS12005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XAV_RS12010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XAV_RS12015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XAV_RS12045	COG2201	protein-glutamate methylesterase activity
XAV_RS12065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAV_RS12070	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_RS12075	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_RS12105	COG1677	Flagellar hook-basal body complex protein FliE
XAV_RS12175	COG1684	flagellar biosynthetic protein fliR
XAV_RS12180	COG5001	Diguanylate cyclase
XAV_RS12180	COG3300	MHYT domain
XAV_RS12185	COG3300	MHYT domain
XAV_RS12185	COG5001	Diguanylate cyclase
XAV_RS12230	COG0784	Response regulator, receiver
XAV_RS12230	COG2198	Histidine kinase
XAV_RS12230	COG0643	Histidine kinase
XAV_RS12255	COG3039	Transposase
XAV_RS12275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XAV_RS12285	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XAV_RS12290	COG1360	Flagellar Motor Protein
XAV_RS12295	COG1192	Involved in chromosome partitioning
XAV_RS12310	COG0745	RESPONSE REGULATOR receiver
XAV_RS12320	COG0840	transmembrane signaling receptor activity
XAV_RS12340	COG0840	transmembrane signaling receptor activity
XAV_RS12350	COG0840	transmembrane signaling receptor activity
XAV_RS12355	COG0840	transmembrane signaling receptor activity
XAV_RS12365	COG0840	transmembrane signaling receptor activity
XAV_RS12370	COG0840	transmembrane signaling receptor activity
XAV_RS12375	COG0840	transmembrane signaling receptor activity
XAV_RS12380	COG0840	transmembrane signaling receptor activity
XAV_RS12395	COG0835	chemotaxis
XAV_RS12405	COG0840	transmembrane signaling receptor activity
XAV_RS12415	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XAV_RS12420	COG2201	protein-glutamate methylesterase activity
XAV_RS12430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAV_RS12460	COG0318	PFAM AMP-dependent synthetase and ligase
XAV_RS12465	COG1024	Enoyl-CoA hydratase
XAV_RS12470	COG2198	Histidine kinase
XAV_RS12470	COG2205	protein histidine kinase activity
XAV_RS12470	COG0784	Response regulator, receiver
XAV_RS12475	COG2198	Histidine kinase
XAV_RS12475	COG2205	protein histidine kinase activity
XAV_RS12475	COG0784	Response regulator, receiver
XAV_RS12485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XAV_RS12515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XAV_RS12525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAV_RS12530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XAV_RS12545	COG0505	Belongs to the CarA family
XAV_RS12550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XAV_RS12605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XAV_RS12625	COG0277	FAD linked oxidase domain protein
XAV_RS12630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XAV_RS12640	COG0531	amino acid
XAV_RS12645	COG0531	amino acid
XAV_RS12650	COG0235	Class ii aldolase
XAV_RS12655	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XAV_RS12660	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XAV_RS12740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XAV_RS12740	COG0140	phosphoribosyl-ATP diphosphatase activity
XAV_RS12745	COG0107	imidazoleglycerol-phosphate synthase activity
XAV_RS12750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XAV_RS12755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XAV_RS12760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XAV_RS12760	COG0131	Imidazoleglycerol-phosphate dehydratase
XAV_RS12765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAV_RS12770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XAV_RS12775	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XAV_RS12785	COG0124	histidyl-tRNA synthetase
XAV_RS12795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAV_RS12825	COG0083	homoserine kinase activity
XAV_RS12860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XAV_RS12870	COG1862	Preprotein translocase
XAV_RS12875	COG0343	queuine tRNA-ribosyltransferase activity
XAV_RS12915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XAV_RS12920	COG3291	Pkd domain containing protein
XAV_RS12930	COG0405	Gamma-glutamyltransferase
XAV_RS12935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XAV_RS12945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XAV_RS12950	COG0742	ribosomal rna small subunit methyltransferase
XAV_RS12955	COG0326	Molecular chaperone. Has ATPase activity
XAV_RS12975	COG3039	Transposase
XAV_RS13000	COG2902	Dehydrogenase
XAV_RS13010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAV_RS13015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAV_RS13020	COG1609	Transcriptional regulator
XAV_RS13025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAV_RS13025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XAV_RS13030	COG1105	Belongs to the carbohydrate kinase PfkB family
XAV_RS13035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XAV_RS13035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XAV_RS13065	COG1469	GTP cyclohydrolase I activity
XAV_RS13070	COG0860	N-Acetylmuramoyl-L-alanine amidase
XAV_RS13080	COG3039	Transposase
XAV_RS13090	COG1070	Carbohydrate kinase
XAV_RS13100	COG1501	Belongs to the glycosyl hydrolase 31 family
XAV_RS13155	COG0800	Aldolase
XAV_RS13160	COG4948	Mandelate Racemase Muconate Lactonizing
XAV_RS13170	COG3734	2-keto-3-deoxy-galactonokinase
XAV_RS13175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XAV_RS13185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XAV_RS13200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XAV_RS13205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XAV_RS13220	COG0351	phosphomethylpyrimidine kinase
XAV_RS13245	COG0583	DNA-binding transcription factor activity
XAV_RS13250	COG1741	Belongs to the pirin family
XAV_RS13290	COG3040	lipid binding
XAV_RS13300	COG1960	acyl-CoA dehydrogenase activity
XAV_RS13310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XAV_RS13330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAV_RS13365	COG0438	transferase activity, transferring glycosyl groups
XAV_RS13375	COG0438	transferase activity, transferring glycosyl groups
XAV_RS13380	COG0438	transferase activity, transferring glycosyl groups
XAV_RS13430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAV_RS13430	COG0072	phenylalanine-tRNA ligase activity
XAV_RS13435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XAV_RS13450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XAV_RS13455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XAV_RS13485	COG2801	Transposase and inactivated derivatives
XAV_RS13510	COG0556	nucleotide-excision repair
XAV_RS13555	COG3275	phosphorelay sensor kinase activity
XAV_RS13560	COG1611	Belongs to the LOG family
XAV_RS13570	COG2095	MarC family integral membrane protein
XAV_RS13580	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XAV_RS13615	COG1185	polyribonucleotide nucleotidyltransferase activity
XAV_RS13620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XAV_RS13625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XAV_RS13630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XAV_RS13635	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XAV_RS13640	COG0195	Participates in both transcription termination and antitermination
XAV_RS13645	COG0779	Required for maturation of 30S ribosomal subunits
XAV_RS13655	COG1007	ATP synthesis coupled electron transport
XAV_RS13680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAV_RS13685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XAV_RS13690	COG1034	ATP synthesis coupled electron transport
XAV_RS13695	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XAV_RS13700	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XAV_RS13705	COG0649	NAD binding
XAV_RS13710	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAV_RS13715	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAV_RS13720	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAV_RS13735	COG0149	triose-phosphate isomerase activity
XAV_RS13740	COG4221	oxidoreductase activity
XAV_RS13770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XAV_RS13775	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XAV_RS13780	COG0159	tryptophan synthase activity
XAV_RS13790	COG0133	tryptophan synthase activity
XAV_RS13800	COG0135	phosphoribosylanthranilate isomerase activity
XAV_RS13805	COG0101	tRNA pseudouridine synthase activity
XAV_RS13820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XAV_RS13825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XAV_RS13830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XAV_RS13835	COG2890	protein-(glutamine-N5) methyltransferase activity
XAV_RS13845	COG0688	phosphatidylethanolamine metabolic process
XAV_RS13855	COG0433	COG0433 Predicted ATPase
XAV_RS13875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XAV_RS13900	COG0717	Belongs to the dCTP deaminase family
XAV_RS13905	COG0489	protein tyrosine kinase activity
XAV_RS13925	COG3590	peptidase
XAV_RS13930	COG3590	peptidase
XAV_RS13950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XAV_RS13955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAV_RS13960	COG2311	Membrane
XAV_RS13965	COG1047	Peptidyl-prolyl cis-trans
XAV_RS13970	COG0791	NLP P60 protein
XAV_RS13975	COG0791	NLP P60 protein
XAV_RS13995	COG1301	dicarboxylic acid transport
XAV_RS14000	COG1785	Belongs to the alkaline phosphatase family
XAV_RS14005	COG0037	tRNA processing
XAV_RS14010	COG1722	exodeoxyribonuclease VII activity
XAV_RS14015	COG0142	geranyltranstransferase activity
XAV_RS14030	COG0312	modulator of DNA gyrase
XAV_RS14035	COG3028	Belongs to the UPF0307 family
XAV_RS14040	COG0312	modulator of DNA gyrase
XAV_RS14050	COG3164	Protein of unknown function
XAV_RS14055	COG1530	ribonuclease E activity
XAV_RS14060	COG0424	maF-like protein
XAV_RS14065	COG2968	Membrane
XAV_RS14080	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XAV_RS14100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XAV_RS14115	COG0495	leucyl-tRNA aminoacylation
XAV_RS14125	COG3118	belongs to the thioredoxin family
XAV_RS14150	COG2155	Conserved Protein
XAV_RS14205	COG1132	(ABC) transporter
XAV_RS14240	COG5000	phosphorelay sensor kinase activity
XAV_RS14240	COG5002	protein histidine kinase activity
XAV_RS14245	COG0475	glutathione-regulated potassium exporter activity
XAV_RS14255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XAV_RS14290	COG1187	pseudouridine synthase activity
XAV_RS14295	COG5002	protein histidine kinase activity
XAV_RS14295	COG5001	Diguanylate cyclase
XAV_RS14420	COG0583	DNA-binding transcription factor activity
XAV_RS14475	COG0735	belongs to the Fur family
XAV_RS14480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAV_RS14505	COG4452	Inner membrane protein CreD
XAV_RS14520	COG0745	RESPONSE REGULATOR receiver
XAV_RS14525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XAV_RS14535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XAV_RS14545	COG0643	Histidine kinase
XAV_RS14545	COG2198	Histidine kinase
XAV_RS14550	COG0840	transmembrane signaling receptor activity
XAV_RS14555	COG0835	chemotaxis
XAV_RS14565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XAV_RS14570	COG2201	protein-glutamate methylesterase activity
XAV_RS14580	COG3590	peptidase
XAV_RS14590	COG0588	phosphoglycerate mutase activity
XAV_RS14595	COG1515	deoxyribonuclease V activity
XAV_RS14615	COG1741	Belongs to the pirin family
XAV_RS14620	COG1966	Carbon starvation protein
XAV_RS14625	COG2879	small protein
XAV_RS14660	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XAV_RS14665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XAV_RS14670	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XAV_RS14675	COG2080	2 iron, 2 sulfur cluster binding
XAV_RS14685	COG5001	Diguanylate cyclase
XAV_RS14685	COG3706	GGDEF domain
XAV_RS14685	COG2203	Gaf domain
XAV_RS14685	COG4251	negative regulation of phosphorylation
XAV_RS14690	COG0629	single-stranded DNA binding
XAV_RS14695	COG0142	geranyltranstransferase activity
XAV_RS14705	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XAV_RS14720	COG0527	aspartate kinase activity
XAV_RS14730	COG0384	phenazine biosynthesis protein PhzF
XAV_RS14740	COG1764	response to oxidative stress
XAV_RS14745	COG0540	Belongs to the ATCase OTCase family
XAV_RS14750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XAV_RS14755	COG1678	Uncharacterized ACR, COG1678
XAV_RS14760	COG0519	Catalyzes the synthesis of GMP from XMP
XAV_RS14785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XAV_RS14840	COG1959	2 iron, 2 sulfur cluster binding
XAV_RS14845	COG0719	Fe-S assembly protein
XAV_RS14850	COG0396	ATPase activity
XAV_RS14855	COG0719	Fe-S assembly protein
XAV_RS14860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XAV_RS14865	COG0456	acetyltransferase
XAV_RS14870	COG2146	nitrite reductase [NAD(P)H] activity
XAV_RS14875	COG4774	siderophore transport
XAV_RS14880	COG3128	pkhd-type hydroxylase
XAV_RS14905	COG1555	photosystem II stabilization
XAV_RS14910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAV_RS14920	COG3178	'Phosphotransferase
XAV_RS14925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XAV_RS14935	COG0628	permease
XAV_RS14945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XAV_RS14960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XAV_RS14980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XAV_RS14985	COG0271	Belongs to the BolA IbaG family
XAV_RS14995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XAV_RS15005	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XAV_RS15010	COG1137	ATPase activity
XAV_RS15025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAV_RS15030	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XAV_RS15035	COG1660	Displays ATPase and GTPase activities
XAV_RS15070	COG4772	TonB-dependent receptor
XAV_RS15080	COG4264	IucA IucC family
XAV_RS15085	COG2814	Major facilitator Superfamily
XAV_RS15095	COG0019	diaminopimelate decarboxylase activity
XAV_RS15120	COG0542	response to heat
XAV_RS15220	COG1877	trehalose-phosphatase activity
XAV_RS15225	COG3387	PFAM Glycoside hydrolase 15-related
XAV_RS15245	COG2201	protein-glutamate methylesterase activity
XAV_RS15320	COG2197	response regulator
XAV_RS15325	COG4585	Histidine kinase
XAV_RS15335	COG0850	regulation of cytokinetic process
XAV_RS15340	COG2894	cell division
XAV_RS15345	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XAV_RS15355	COG0642	Histidine kinase
XAV_RS15360	COG0745	RESPONSE REGULATOR receiver
XAV_RS15375	COG2194	sulfuric ester hydrolase activity
XAV_RS15390	COG2814	Major facilitator Superfamily
XAV_RS15415	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XAV_RS15415	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XAV_RS15430	COG0656	L-ascorbic acid biosynthetic process
XAV_RS15435	COG0753	catalase activity
XAV_RS15465	COG1917	Cupin 2, conserved barrel domain protein
XAV_RS15465	COG2207	Transcriptional regulator
XAV_RS15480	COG1506	peptidase
XAV_RS15480	COG0823	Involved in the tonB-independent uptake of proteins
XAV_RS15490	COG1297	OPT oligopeptide transporter protein
XAV_RS15510	COG0587	DNA-directed DNA polymerase activity
XAV_RS15525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XAV_RS15560	COG2080	2 iron, 2 sulfur cluster binding
XAV_RS15565	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XAV_RS15570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XAV_RS15615	COG0492	ferredoxin-NADP+ reductase activity
XAV_RS15625	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_RS15695	COG0732	type I restriction modification DNA specificity domain
XAV_RS15755	COG2814	Major facilitator Superfamily
XAV_RS15840	COG0314	molybdopterin synthase activity
XAV_RS15845	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XAV_RS15850	COG0315	cyclic pyranopterin monophosphate synthase activity
XAV_RS15860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XAV_RS15865	COG1234	tRNA 3'-trailer cleavage
XAV_RS15870	COG3642	lipopolysaccharide core region biosynthetic process
XAV_RS15875	COG0859	PFAM glycosyl transferase family 9
XAV_RS15890	COG0631	protein serine/threonine phosphatase activity
XAV_RS15895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XAV_RS15900	COG0328	RNA-DNA hybrid ribonuclease activity
XAV_RS15910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAV_RS15920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAV_RS15950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XAV_RS15960	COG0544	peptidyl-prolyl cis-trans isomerase activity
XAV_RS16020	COG0473	3-isopropylmalate dehydrogenase activity
XAV_RS16035	COG4783	chaperone-mediated protein folding
XAV_RS16050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XAV_RS16060	COG0438	transferase activity, transferring glycosyl groups
XAV_RS16065	COG0671	phosphoesterase, PA-phosphatase related
XAV_RS16070	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAV_RS16085	COG2833	Protein of unknown function (DUF455)
XAV_RS16105	COG0285	dihydrofolate synthase activity
XAV_RS16125	COG0406	alpha-ribazole phosphatase activity
XAV_RS16135	COG3039	Transposase
XAV_RS16165	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XAV_RS16170	COG4208	sulfate ABC transporter
XAV_RS16175	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XAV_RS16180	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XAV_RS16185	COG0156	8-amino-7-oxononanoate synthase activity
XAV_RS16205	COG2885	chlorophyll binding
XAV_RS16210	COG0604	alcohol dehydrogenase
XAV_RS16215	COG0446	pyridine nucleotide-disulphide oxidoreductase
XAV_RS16215	COG1902	pentaerythritol trinitrate reductase activity
XAV_RS16240	COG0039	L-malate dehydrogenase activity
XAV_RS16245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XAV_RS16275	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XAV_RS16285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XAV_RS16290	COG0203	ribosomal protein L17
XAV_RS16315	COG0201	protein transport
XAV_RS16320	COG0200	Binds to the 23S rRNA
XAV_RS16325	COG1841	ribosomal large subunit assembly
XAV_RS16335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XAV_RS16340	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XAV_RS16355	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XAV_RS16360	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XAV_RS16370	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XAV_RS16375	COG0255	Belongs to the universal ribosomal protein uL29 family
XAV_RS16385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XAV_RS16395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XAV_RS16400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XAV_RS16405	COG0089	rRNA binding
XAV_RS16410	COG0088	Forms part of the polypeptide exit tunnel
XAV_RS16415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XAV_RS16420	COG0051	transcription antitermination factor activity, RNA binding
XAV_RS16435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XAV_RS16440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XAV_RS16445	COG0049	tRNA binding
XAV_RS16450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XAV_RS16455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XAV_RS16460	COG0085	RNA polymerase activity
XAV_RS16470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XAV_RS16475	COG0081	regulation of translation
XAV_RS16480	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XAV_RS16485	COG0250	Participates in transcription elongation, termination and antitermination
XAV_RS16490	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XAV_RS16500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XAV_RS16520	COG0012	GTP binding
XAV_RS16525	COG0193	aminoacyl-tRNA hydrolase activity
XAV_RS16530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XAV_RS16535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XAV_RS16545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XAV_RS16550	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XAV_RS16560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XAV_RS16565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XAV_RS16575	COG0521	Mo-molybdopterin cofactor biosynthetic process
XAV_RS16590	COG1254	Belongs to the acylphosphatase family
XAV_RS16595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAV_RS16600	COG1295	ribonuclease BN
XAV_RS16625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XAV_RS16630	COG1404	Belongs to the peptidase S8 family
XAV_RS16635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XAV_RS16700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAV_RS16700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAV_RS16720	COG2890	protein-(glutamine-N5) methyltransferase activity
XAV_RS16730	COG3634	alkyl hydroperoxide reductase activity
XAV_RS16735	COG0583	DNA-binding transcription factor activity
XAV_RS16740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAV_RS16745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XAV_RS16755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XAV_RS16765	COG2197	response regulator
XAV_RS16800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAV_RS16805	COG0697	spore germination
XAV_RS16835	COG3386	PFAM SMP-30 Gluconolaconase
XAV_RS16855	COG1024	Enoyl-CoA hydratase
XAV_RS16865	COG0318	PFAM AMP-dependent synthetase and ligase
XAV_RS16870	COG0583	DNA-binding transcription factor activity
XAV_RS16875	COG3384	dioxygenase
XAV_RS16915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAV_RS16920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAV_RS16930	COG2096	Adenosyltransferase
XAV_RS16935	COG0123	including yeast histone deacetylase and acetoin utilization protein
XAV_RS16940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XAV_RS16945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAV_RS16950	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XAV_RS16955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XAV_RS16960	COG2967	ApaG domain
XAV_RS16965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XAV_RS16985	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XAV_RS16990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XAV_RS17000	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
XAV_RS17010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XAV_RS17020	COG0642	Histidine kinase
XAV_RS17035	COG4181	ATPase activity
XAV_RS17045	COG2175	clavaminate synthase activity
XAV_RS17055	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XAV_RS17060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XAV_RS17085	COG0667	Aldo Keto reductase
XAV_RS17090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XAV_RS17095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAV_RS17140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XAV_RS17145	COG4106	trans-aconitate 2-methyltransferase activity
XAV_RS17155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XAV_RS17190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XAV_RS17200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XAV_RS17205	COG2226	methyltransferase
XAV_RS17235	COG0366	Alpha amylase catalytic
XAV_RS17260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XAV_RS17270	COG0494	nUDIX hydrolase
XAV_RS17275	COG0653	protein targeting
XAV_RS17280	COG0739	heme binding
XAV_RS17290	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XAV_RS17305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XAV_RS17310	COG1181	Belongs to the D-alanine--D-alanine ligase family
XAV_RS17315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XAV_RS17320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XAV_RS17330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XAV_RS17335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XAV_RS17340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XAV_RS17350	COG3116	cell division
XAV_RS17355	COG0275	rRNA processing
XAV_RS17385	COG0792	nuclease activity
XAV_RS17390	COG1988	membrane-bound metal-dependent
XAV_RS17395	COG0277	FAD linked oxidase domain protein
XAV_RS17405	COG0745	RESPONSE REGULATOR receiver
XAV_RS17410	COG2205	protein histidine kinase activity
XAV_RS17420	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XAV_RS17425	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XAV_RS17460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XAV_RS17465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XAV_RS17470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XAV_RS17490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XAV_RS17490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XAV_RS17500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XAV_RS17505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XAV_RS17530	COG0488	(ABC) transporter
XAV_RS17545	COG3791	Glutathione-dependent formaldehyde-activating
XAV_RS17595	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XAV_RS17610	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XAV_RS17620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
XAV_RS17625	COG0174	glutamine synthetase
XAV_RS17650	COG0745	RESPONSE REGULATOR receiver
XAV_RS17655	COG2205	protein histidine kinase activity
XAV_RS17725	COG0617	tRNA 3'-terminal CCA addition
XAV_RS17740	COG0726	polysaccharide deacetylase
XAV_RS17740	COG1649	PFAM Uncharacterised BCR, COG1649
XAV_RS17745	COG1215	transferase activity, transferring glycosyl groups
XAV_RS17760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XAV_RS17765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XAV_RS17770	COG1609	Transcriptional regulator
XAV_RS17780	COG2188	Transcriptional regulator
XAV_RS17855	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XAV_RS17860	COG4191	Histidine kinase
XAV_RS17865	COG0784	Response regulator, receiver
XAV_RS17870	COG4251	negative regulation of phosphorylation
XAV_RS17875	COG2823	Periplasmic or secreted lipoprotein
XAV_RS17880	COG0673	inositol 2-dehydrogenase activity
XAV_RS17885	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XAV_RS17930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XAV_RS17935	COG0321	lipoyl(octanoyl) transferase activity
XAV_RS17940	COG2921	Belongs to the UPF0250 family
XAV_RS17950	COG1686	Belongs to the peptidase S11 family
XAV_RS17955	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XAV_RS17960	COG2951	lytic endotransglycosylase activity
XAV_RS17970	COG0772	Belongs to the SEDS family
XAV_RS17985	COG1792	Involved in formation and maintenance of cell shape
XAV_RS17990	COG1077	Cell shape determining protein MreB Mrl
XAV_RS17995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAV_RS18010	COG3039	Transposase
XAV_RS18025	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
XAV_RS18025	COG0028	Belongs to the TPP enzyme family
XAV_RS18035	COG1213	nucleotidyl transferase
XAV_RS18040	COG0367	asparagine synthase
XAV_RS18050	COG0730	response to heat
XAV_RS18085	COG0308	aminopeptidase N
XAV_RS18090	COG3300	MHYT domain
XAV_RS18090	COG5001	Diguanylate cyclase
XAV_RS18125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XAV_RS18130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XAV_RS18135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XAV_RS18145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XAV_RS18155	COG2832	Protein of unknown function (DUF454)
XAV_RS18170	COG1505	serine-type exopeptidase activity
XAV_RS18200	COG0181	hydroxymethylbilane synthase activity
XAV_RS18210	COG3275	phosphorelay sensor kinase activity
XAV_RS18220	COG2943	transferase activity, transferring hexosyl groups
XAV_RS18245	COG0659	secondary active sulfate transmembrane transporter activity
XAV_RS18250	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAV_RS18250	COG5297	Belongs to the glycosyl hydrolase family 6
XAV_RS18255	COG0840	transmembrane signaling receptor activity
XAV_RS18310	COG0598	Magnesium transport protein CorA
XAV_RS18320	COG1113	amino acid transport
XAV_RS18335	COG5297	Belongs to the glycosyl hydrolase family 6
XAV_RS18340	COG3039	Transposase
XAV_RS18345	COG4305	rare lipoprotein A
XAV_RS18350	COG0697	spore germination
XAV_RS18430	COG4221	oxidoreductase activity
XAV_RS18460	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XAV_RS18460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAV_RS18515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XAV_RS18520	COG1490	D-aminoacyl-tRNA deacylase activity
XAV_RS18525	COG1560	Kdo2-lipid A biosynthetic process
XAV_RS18570	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XAV_RS18570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XAV_RS18575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XAV_RS18580	COG0242	peptide deformylase activity
XAV_RS18585	COG1652	LysM domain
XAV_RS18590	COG0758	DNA mediated transformation
XAV_RS18615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XAV_RS18615	COG1754	DNA topoisomerase type I activity
XAV_RS18620	COG0009	L-threonylcarbamoyladenylate synthase
XAV_RS18635	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_RS18645	COG0616	signal peptide processing
XAV_RS18650	COG0534	Mate efflux family protein
XAV_RS18670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XAV_RS18690	COG1252	NADH dehydrogenase
XAV_RS18700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XAV_RS18705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XAV_RS18710	COG2201	protein-glutamate methylesterase activity
XAV_RS18715	COG2177	Part of the ABC transporter FtsEX involved in
XAV_RS18720	COG2884	Cell division ATP-binding protein ftsE
XAV_RS18725	COG0513	Belongs to the DEAD box helicase family
XAV_RS18730	COG3118	belongs to the thioredoxin family
XAV_RS18735	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XAV_RS18780	COG1518	maintenance of DNA repeat elements
XAV_RS18785	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
XAV_RS18800	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XAV_RS18800	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XAV_RS18805	COG1473	amidohydrolase
XAV_RS18810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAV_RS18815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAV_RS18825	COG5383	Protein conserved in bacteria
XAV_RS18870	COG3023	N-Acetylmuramoyl-L-alanine amidase
XAV_RS18880	COG4948	Mandelate Racemase Muconate Lactonizing
XAV_RS18895	COG0531	amino acid
XAV_RS18910	COG4682	membrane
XAV_RS18915	COG2133	pyrroloquinoline quinone binding
XAV_RS18925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XAV_RS18930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XAV_RS18940	COG1610	YqeY-like protein
XAV_RS18950	COG1295	ribonuclease BN
XAV_RS18955	COG0358	DNA primase activity
XAV_RS18970	COG0109	protoheme IX farnesyltransferase activity
XAV_RS19000	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XAV_RS19015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XAV_RS19065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XAV_RS19070	COG0739	heme binding
XAV_RS19075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XAV_RS19085	COG2223	nitrite transmembrane transporter activity
XAV_RS19090	COG0708	Exodeoxyribonuclease III
XAV_RS19095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XAV_RS19105	COG1192	Involved in chromosome partitioning
XAV_RS19110	COG1475	DNA binding
XAV_RS19130	COG0463	Glycosyl transferase, family 2
XAV_RS19150	COG0756	dUTP diphosphatase activity
XAV_RS19155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XAV_RS19160	COG2003	Belongs to the UPF0758 family
XAV_RS19165	COG0018	arginyl-trna synthetase
XAV_RS19180	COG4221	oxidoreductase activity
XAV_RS19185	COG2755	lipolytic protein G-D-S-L family
XAV_RS19185	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XAV_RS19200	COG1166	arginine decarboxylase activity
XAV_RS19205	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XAV_RS19225	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XAV_RS19225	COG3291	Pkd domain containing protein
XAV_RS19240	COG0606	chelatase, subunit chli
XAV_RS19255	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XAV_RS19310	COG1090	epimerase
XAV_RS19320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XAV_RS19345	COG1011	Hydrolase
XAV_RS19350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XAV_RS19365	COG0753	catalase activity
XAV_RS19415	COG0180	Tryptophanyl-tRNA synthetase
XAV_RS19420	COG3237	CsbD-like
XAV_RS19460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XAV_RS19475	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XAV_RS19480	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XAV_RS19480	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XAV_RS19505	COG2205	protein histidine kinase activity
XAV_RS19510	COG0745	RESPONSE REGULATOR receiver
XAV_RS19520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XAV_RS19540	COG1199	ATP-dependent helicase activity
XAV_RS19555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XAV_RS19565	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XAV_RS19645	COG4555	ABC transporter
XAV_RS19655	COG1476	TRANSCRIPTIONal
XAV_RS19670	COG1230	cation diffusion facilitator family transporter
XAV_RS19675	COG0543	2 iron, 2 sulfur cluster binding
XAV_RS19675	COG0633	Ferredoxin
XAV_RS19680	COG1131	(ABC) transporter
XAV_RS19685	COG0842	Transport permease protein
XAV_RS19730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XAV_RS19735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XAV_RS19745	COG1042	CoA-binding domain protein
XAV_RS19745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XAV_RS19745	COG0045	succinate-CoA ligase (ADP-forming) activity
XAV_RS19755	COG2239	Acts as a magnesium transporter
XAV_RS19770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XAV_RS19775	COG3387	PFAM Glycoside hydrolase 15-related
XAV_RS19790	COG3100	YcgL domain-containing protein
XAV_RS19795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XAV_RS19805	COG0463	Glycosyl transferase, family 2
XAV_RS19815	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_RS19840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAV_RS19855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XAV_RS19895	COG0408	coproporphyrinogen oxidase activity
XAV_RS19905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAV_RS19905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAV_RS19935	COG0154	amidase activity
XAV_RS19955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XAV_RS19975	COG2072	flavoprotein involved in K transport
XAV_RS19980	COG2351	hydroxyisourate hydrolase activity
XAV_RS19985	COG4807	Protein conserved in bacteria
XAV_RS19995	COG1643	Atp-dependent helicase
XAV_RS20005	COG1187	pseudouridine synthase activity
XAV_RS20020	COG2130	NADP-dependent
XAV_RS20025	COG0656	L-ascorbic acid biosynthetic process
XAV_RS20050	COG1764	response to oxidative stress
XAV_RS20055	COG1846	Transcriptional regulator
XAV_RS20080	COG0084	hydrolase, TatD family'
XAV_RS20100	COG2252	PERMEase
XAV_RS20140	COG3039	Transposase
XAV_RS20150	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XAV_RS20160	COG0697	spore germination
XAV_RS20225	COG1960	acyl-CoA dehydrogenase activity
XAV_RS20230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XAV_RS20235	COG4770	biotin carboxylase activity
XAV_RS20290	COG0339	signal peptide processing
XAV_RS20315	COG0564	pseudouridine synthase activity
XAV_RS20325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XAV_RS20335	COG1181	Belongs to the D-alanine--D-alanine ligase family
XAV_RS20350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAV_RS20360	COG0318	PFAM AMP-dependent synthetase and ligase
XAV_RS20365	COG0727	PFAM Uncharacterised protein family (UPF0153)
XAV_RS20370	COG0596	Alpha beta hydrolase
XAV_RS20385	COG3177	Filamentation induced by cAMP protein fic
XAV_RS20390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAV_RS20405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XAV_RS20430	COG4191	Histidine kinase
XAV_RS20435	COG0028	Belongs to the TPP enzyme family
XAV_RS20450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XAV_RS20455	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XAV_RS20460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XAV_RS20495	COG0183	Belongs to the thiolase family
XAV_RS20515	COG2032	superoxide dismutase activity
XAV_RS20520	COG2032	superoxide dismutase activity
XAV_RS20525	COG2204	response regulator
XAV_RS20530	COG3852	Histidine kinase
XAV_RS20535	COG0004	ammonium transporteR
XAV_RS20540	COG0347	Belongs to the P(II) protein family
XAV_RS20545	COG0174	glutamine synthetase
XAV_RS20550	COG1968	undecaprenyl-diphosphatase activity
XAV_RS20595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAV_RS20605	COG2062	phosphohistidine phosphatase, SixA
XAV_RS20610	COG0489	protein tyrosine kinase activity
XAV_RS20635	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
XAV_RS20640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XAV_RS20655	COG0517	IMP dehydrogenase activity
XAV_RS20655	COG1125	glycine betaine transport
XAV_RS20670	COG1119	ATPase activity
XAV_RS20705	COG1473	amidohydrolase
XAV_RS20710	COG1752	Esterase of the alpha-beta hydrolase superfamily
XAV_RS20720	COG1522	sequence-specific DNA binding
XAV_RS20725	COG3186	Phenylalanine-4-hydroxylase
XAV_RS20745	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_RS20755	COG1609	Transcriptional regulator
XAV_RS20780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XAV_RS20790	COG0657	acetylesterase activity
XAV_RS20790	COG2755	lipolytic protein G-D-S-L family
XAV_RS20810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAV_RS20815	COG0366	Alpha amylase catalytic
XAV_RS20820	COG0366	Alpha amylase catalytic
XAV_RS20860	COG2201	protein-glutamate methylesterase activity
XAV_RS20885	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XAV_RS20905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XAV_RS20965	COG3135	benzoate transporter
XAV_RS20985	COG0676	glucose-6-phosphate 1-epimerase activity
XAV_RS20995	COG3012	SEC-C Motif Domain Protein
XAV_RS21000	COG0730	response to heat
XAV_RS21025	COG0302	gtp cyclohydrolase
XAV_RS21055	COG0477	Major facilitator Superfamily
XAV_RS21165	COG0439	Biotin carboxylase
XAV_RS21210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XAV_RS21215	COG1074	ATP-dependent DNA helicase activity
XAV_RS21220	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XAV_RS21225	COG1116	anion transmembrane transporter activity
XAV_RS21250	COG1136	(ABC) transporter
XAV_RS21265	COG1127	ABC transporter
XAV_RS21270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XAV_RS21275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XAV_RS21290	COG2853	Lipoprotein
XAV_RS21310	COG0386	Belongs to the glutathione peroxidase family
XAV_RS21320	COG1322	Protein conserved in bacteria
XAV_RS21350	COG0531	amino acid
XAV_RS21385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XAV_RS21390	COG0861	Integral membrane protein TerC family
XAV_RS21400	COG0584	glycerophosphoryl diester phosphodiesterase
XAV_RS21415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XAV_RS21430	COG0706	membrane insertase activity
XAV_RS21435	COG0594	ribonuclease P activity
XAV_RS21520	COG2336	PFAM SpoVT AbrB
XAV_RS21525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XAV_RS21530	COG1192	Involved in chromosome partitioning