locus-tag	class	description
KWO_RS00025	COG0187	DNA topoisomerase II activity
KWO_RS00035	COG0501	Belongs to the peptidase M48B family
KWO_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KWO_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KWO_RS00115	COG0793	Belongs to the peptidase S41A family
KWO_RS00120	COG4942	peptidase
KWO_RS00130	COG2234	aminopeptidase activity
KWO_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KWO_RS00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KWO_RS00165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KWO_RS00175	COG1064	alcohol dehydrogenase
KWO_RS00195	COG0493	'glutamate synthase
KWO_RS00200	COG0067	glutamate synthase
KWO_RS00200	COG0070	glutamate synthase
KWO_RS00200	COG0069	glutamate synthase activity
KWO_RS00285	COG1111	helicase
KWO_RS00285	COG1205	dead DEAH box helicase
KWO_RS00290	COG1272	protein, Hemolysin III
KWO_RS00320	COG2249	NAD(P)H dehydrogenase (quinone) activity
KWO_RS00350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KWO_RS00405	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
KWO_RS00415	COG4772	TonB-dependent receptor
KWO_RS00440	COG1304	FMN binding
KWO_RS00470	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KWO_RS00505	COG2831	hemolysin activation secretion protein
KWO_RS00515	COG0366	Alpha amylase catalytic
KWO_RS00520	COG0366	Alpha amylase catalytic
KWO_RS00545	COG0657	acetylesterase activity
KWO_RS00545	COG2755	lipolytic protein G-D-S-L family
KWO_RS00555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KWO_RS00570	COG3507	Belongs to the glycosyl hydrolase 43 family
KWO_RS00575	COG1609	Transcriptional regulator
KWO_RS00580	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
KWO_RS00585	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS00595	COG2755	lipolytic protein G-D-S-L family
KWO_RS00605	COG3186	Phenylalanine-4-hydroxylase
KWO_RS00610	COG1522	sequence-specific DNA binding
KWO_RS00625	COG2951	lytic endotransglycosylase activity
KWO_RS00630	COG1752	Esterase of the alpha-beta hydrolase superfamily
KWO_RS00635	COG1473	amidohydrolase
KWO_RS00645	COG1119	ATPase activity
KWO_RS00660	COG0517	IMP dehydrogenase activity
KWO_RS00660	COG1125	glycine betaine transport
KWO_RS00675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KWO_RS00715	COG0489	protein tyrosine kinase activity
KWO_RS00720	COG2062	phosphohistidine phosphatase, SixA
KWO_RS00730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KWO_RS00785	COG1968	undecaprenyl-diphosphatase activity
KWO_RS00790	COG0174	glutamine synthetase
KWO_RS00795	COG0347	Belongs to the P(II) protein family
KWO_RS00800	COG0004	ammonium transporteR
KWO_RS00805	COG3852	Histidine kinase
KWO_RS00810	COG2204	response regulator
KWO_RS00815	COG2032	superoxide dismutase activity
KWO_RS00830	COG0346	lactoylglutathione lyase activity
KWO_RS00840	COG0183	Belongs to the thiolase family
KWO_RS00880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KWO_RS00885	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KWO_RS00890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KWO_RS00900	COG0028	Belongs to the TPP enzyme family
KWO_RS00905	COG2205	protein histidine kinase activity
KWO_RS00930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KWO_RS00945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KWO_RS00950	COG3177	Filamentation induced by cAMP protein fic
KWO_RS00965	COG0596	Alpha beta hydrolase
KWO_RS00970	COG0727	PFAM Uncharacterised protein family (UPF0153)
KWO_RS00975	COG0318	PFAM AMP-dependent synthetase and ligase
KWO_RS00980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KWO_RS01000	COG1181	Belongs to the D-alanine--D-alanine ligase family
KWO_RS01010	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KWO_RS01015	COG4122	O-methyltransferase activity
KWO_RS01020	COG0564	pseudouridine synthase activity
KWO_RS01040	COG1446	asparaginase
KWO_RS01045	COG0339	signal peptide processing
KWO_RS01075	COG0475	glutathione-regulated potassium exporter activity
KWO_RS01085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KWO_RS01090	COG2224	Isocitrate lyase
KWO_RS01120	COG4770	biotin carboxylase activity
KWO_RS01125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KWO_RS01130	COG1960	acyl-CoA dehydrogenase activity
KWO_RS01195	COG0697	spore germination
KWO_RS01205	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KWO_RS01215	COG1846	Transcriptional regulator
KWO_RS01220	COG1764	response to oxidative stress
KWO_RS01260	COG1187	pseudouridine synthase activity
KWO_RS01270	COG1643	Atp-dependent helicase
KWO_RS01275	COG4807	Protein conserved in bacteria
KWO_RS01280	COG2351	hydroxyisourate hydrolase activity
KWO_RS01285	COG2072	flavoprotein involved in K transport
KWO_RS01305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KWO_RS01350	COG2252	PERMEase
KWO_RS01370	COG0084	hydrolase, TatD family'
KWO_RS01405	COG2814	Major facilitator Superfamily
KWO_RS01410	COG4221	oxidoreductase activity
KWO_RS01420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KWO_RS01425	COG1902	pentaerythritol trinitrate reductase activity
KWO_RS01450	COG0745	RESPONSE REGULATOR receiver
KWO_RS01470	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KWO_RS01475	COG0583	DNA-binding transcription factor activity
KWO_RS01510	COG0702	epimerase
KWO_RS01515	COG1733	regulation of RNA biosynthetic process
KWO_RS01560	COG0129	dihydroxy-acid dehydratase activity
KWO_RS01575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KWO_RS01640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KWO_RS01670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KWO_RS01675	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KWO_RS01685	COG3485	protocatechuate 3,4-dioxygenase
KWO_RS01690	COG3485	protocatechuate 3,4-dioxygenase
KWO_RS01705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KWO_RS01710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KWO_RS01715	COG1414	Transcriptional regulator
KWO_RS01725	COG0657	acetylesterase activity
KWO_RS01730	COG0445	tRNA wobble uridine modification
KWO_RS01740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KWO_RS01785	COG0156	8-amino-7-oxononanoate synthase activity
KWO_RS01795	COG1040	competence protein
KWO_RS01830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KWO_RS01925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KWO_RS02000	COG1511	domain protein
KWO_RS02000	COG3264	Mechanosensitive ion channel
KWO_RS02015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KWO_RS02020	COG2354	Protein conserved in bacteria
KWO_RS02025	COG1649	PFAM Uncharacterised BCR, COG1649
KWO_RS02035	COG0297	glycogen (starch) synthase activity
KWO_RS02040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KWO_RS02045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KWO_RS02070	COG0702	epimerase
KWO_RS02100	COG0513	Belongs to the DEAD box helicase family
KWO_RS02115	COG0508	dehydrogenase complex catalyzes the overall conversion of
KWO_RS02130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KWO_RS02145	COG3483	tryptophan 2,3-dioxygenase activity
KWO_RS02150	COG3104	oligopeptide transport
KWO_RS02170	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KWO_RS02230	COG1320	monovalent cation:proton antiporter activity
KWO_RS02235	COG2212	antiporter activity
KWO_RS02245	COG0651	ATP synthesis coupled electron transport
KWO_RS02250	COG1006	Multisubunit Na H antiporter MnhC subunit
KWO_RS02255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KWO_RS02255	COG2111	Na H antiporter
KWO_RS02310	COG3039	Transposase
KWO_RS02325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KWO_RS02330	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KWO_RS02340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KWO_RS02345	COG0456	acetyltransferase
KWO_RS02350	COG1597	lipid kinase activity
KWO_RS02380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KWO_RS02385	COG0134	indole-3-glycerol-phosphate synthase activity
KWO_RS02395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KWO_RS02400	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KWO_RS02410	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
KWO_RS02420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KWO_RS02455	COG0745	RESPONSE REGULATOR receiver
KWO_RS02475	COG0316	Belongs to the HesB IscA family
KWO_RS02500	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KWO_RS02520	COG2814	Major facilitator Superfamily
KWO_RS02530	COG2814	Major facilitator Superfamily
KWO_RS02535	COG1289	transmembrane transporter activity
KWO_RS02540	COG0151	Belongs to the GarS family
KWO_RS02550	COG0419	ATPase involved in DNA repair
KWO_RS02555	COG0138	bifunctional purine biosynthesis protein purh
KWO_RS02580	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KWO_RS02630	COG0439	Biotin carboxylase
KWO_RS02640	COG0511	ligase activity, forming carbon-carbon bonds
KWO_RS02645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KWO_RS02655	COG1324	tolerance protein
KWO_RS02665	COG2356	endonuclease I
KWO_RS02680	COG0459	protein refolding
KWO_RS02700	COG4771	TonB-dependent receptor
KWO_RS02705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KWO_RS02725	COG3386	PFAM SMP-30 Gluconolaconase
KWO_RS02735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KWO_RS02785	COG0778	Nitroreductase
KWO_RS02790	COG2353	YceI-like domain
KWO_RS02830	COG3052	prosthetic group binding
KWO_RS02855	COG3321	synthase
KWO_RS02855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KWO_RS02865	COG1802	Transcriptional regulator
KWO_RS02870	COG0546	phosphoglycolate phosphatase activity
KWO_RS03020	COG4221	oxidoreductase activity
KWO_RS03025	COG0435	Glutathione S-transferase
KWO_RS03095	COG0697	spore germination
KWO_RS03115	COG4305	rare lipoprotein A
KWO_RS03125	COG1113	amino acid transport
KWO_RS03210	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KWO_RS03210	COG5297	Belongs to the glycosyl hydrolase family 6
KWO_RS03215	COG0659	secondary active sulfate transmembrane transporter activity
KWO_RS03240	COG2943	transferase activity, transferring hexosyl groups
KWO_RS03250	COG3275	phosphorelay sensor kinase activity
KWO_RS03260	COG0181	hydroxymethylbilane synthase activity
KWO_RS03290	COG1505	serine-type exopeptidase activity
KWO_RS03300	COG0436	Aminotransferase
KWO_RS03315	COG2832	Protein of unknown function (DUF454)
KWO_RS03325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KWO_RS03335	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KWO_RS03350	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KWO_RS03375	COG2226	methyltransferase
KWO_RS03385	COG5001	Diguanylate cyclase
KWO_RS03385	COG3300	MHYT domain
KWO_RS03390	COG0308	aminopeptidase N
KWO_RS03420	COG3293	Transposase
KWO_RS03430	COG0730	response to heat
KWO_RS03435	COG1012	belongs to the aldehyde dehydrogenase family
KWO_RS03440	COG0367	asparagine synthase
KWO_RS03455	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
KWO_RS03455	COG0028	Belongs to the TPP enzyme family
KWO_RS03475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KWO_RS03480	COG1077	Cell shape determining protein MreB Mrl
KWO_RS03485	COG1792	Involved in formation and maintenance of cell shape
KWO_RS03500	COG0772	Belongs to the SEDS family
KWO_RS03515	COG5297	Belongs to the glycosyl hydrolase family 6
KWO_RS03560	COG2951	lytic endotransglycosylase activity
KWO_RS03565	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KWO_RS03570	COG1686	Belongs to the peptidase S11 family
KWO_RS03580	COG2921	Belongs to the UPF0250 family
KWO_RS03585	COG0321	lipoyl(octanoyl) transferase activity
KWO_RS03590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KWO_RS03605	COG1051	belongs to the nudix hydrolase family
KWO_RS03605	COG1056	cytidyltransferase-related domain
KWO_RS03640	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KWO_RS03645	COG0673	inositol 2-dehydrogenase activity
KWO_RS03650	COG2823	Periplasmic or secreted lipoprotein
KWO_RS03655	COG4251	negative regulation of phosphorylation
KWO_RS03660	COG0784	Response regulator, receiver
KWO_RS03665	COG4191	Histidine kinase
KWO_RS03670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KWO_RS03675	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS03705	COG3250	beta-galactosidase activity
KWO_RS03720	COG2188	Transcriptional regulator
KWO_RS03730	COG1609	Transcriptional regulator
KWO_RS03735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KWO_RS03740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KWO_RS03755	COG1215	transferase activity, transferring glycosyl groups
KWO_RS03760	COG0726	polysaccharide deacetylase
KWO_RS03760	COG1649	PFAM Uncharacterised BCR, COG1649
KWO_RS03810	COG0525	valine-tRNA ligase activity
KWO_RS03825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KWO_RS03835	COG0795	lipopolysaccharide-transporting ATPase activity
KWO_RS03845	COG4974	Belongs to the 'phage' integrase family
KWO_RS03850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KWO_RS03865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KWO_RS03865	COG0047	phosphoribosylformylglycinamidine synthase activity
KWO_RS03875	COG5295	Hep Hag repeat protein
KWO_RS03885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KWO_RS03895	COG1459	type II secretion system
KWO_RS03900	COG2165	general secretion pathway protein
KWO_RS03905	COG4970	Tfp pilus assembly protein FimT
KWO_RS03910	COG2165	general secretion pathway protein
KWO_RS03915	COG4795	General secretion pathway protein
KWO_RS03920	COG3156	type II secretion system protein K
KWO_RS03925	COG3166	PFAM Fimbrial assembly family protein
KWO_RS03940	COG1450	Type ii and iii secretion system protein
KWO_RS03950	COG2188	Transcriptional regulator
KWO_RS04010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KWO_RS04040	COG0242	peptide deformylase activity
KWO_RS04045	COG0488	(ABC) transporter
KWO_RS04070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KWO_RS04075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KWO_RS04085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KWO_RS04085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KWO_RS04105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KWO_RS04110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KWO_RS04115	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KWO_RS04160	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KWO_RS04165	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KWO_RS04175	COG2205	protein histidine kinase activity
KWO_RS04180	COG0745	RESPONSE REGULATOR receiver
KWO_RS04185	COG0277	FAD linked oxidase domain protein
KWO_RS04190	COG1988	membrane-bound metal-dependent
KWO_RS04195	COG0792	nuclease activity
KWO_RS04240	COG0275	rRNA processing
KWO_RS04245	COG3116	cell division
KWO_RS04260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KWO_RS04265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KWO_RS04275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KWO_RS04280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KWO_RS04285	COG1181	Belongs to the D-alanine--D-alanine ligase family
KWO_RS04290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KWO_RS04305	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KWO_RS04315	COG0739	heme binding
KWO_RS04320	COG0653	protein targeting
KWO_RS04325	COG0494	nUDIX hydrolase
KWO_RS04340	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KWO_RS04350	COG3321	synthase
KWO_RS04350	COG0604	alcohol dehydrogenase
KWO_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS04400	COG2226	methyltransferase
KWO_RS04405	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KWO_RS04415	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KWO_RS04445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KWO_RS04455	COG4106	trans-aconitate 2-methyltransferase activity
KWO_RS04460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KWO_RS04475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KWO_RS04480	COG0667	Aldo Keto reductase
KWO_RS04495	COG4771	TonB-dependent receptor
KWO_RS04515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KWO_RS04520	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KWO_RS04530	COG2175	clavaminate synthase activity
KWO_RS04540	COG4181	ATPase activity
KWO_RS04555	COG0642	Histidine kinase
KWO_RS04570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KWO_RS04590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KWO_RS04605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KWO_RS04610	COG2967	ApaG domain
KWO_RS04615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KWO_RS04625	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KWO_RS04635	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KWO_RS04640	COG0123	including yeast histone deacetylase and acetoin utilization protein
KWO_RS04645	COG2096	Adenosyltransferase
KWO_RS04660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KWO_RS04665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KWO_RS04690	COG3384	dioxygenase
KWO_RS04695	COG0583	DNA-binding transcription factor activity
KWO_RS04700	COG0318	PFAM AMP-dependent synthetase and ligase
KWO_RS04710	COG1024	Enoyl-CoA hydratase
KWO_RS04730	COG3386	PFAM SMP-30 Gluconolaconase
KWO_RS04755	COG0697	spore germination
KWO_RS04765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KWO_RS04780	COG0784	Response regulator, receiver
KWO_RS04780	COG2205	protein histidine kinase activity
KWO_RS04780	COG5002	protein histidine kinase activity
KWO_RS04785	COG2197	response regulator
KWO_RS04795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KWO_RS04805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KWO_RS04810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KWO_RS04815	COG0583	DNA-binding transcription factor activity
KWO_RS04820	COG3634	alkyl hydroperoxide reductase activity
KWO_RS04830	COG2890	protein-(glutamine-N5) methyltransferase activity
KWO_RS04865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWO_RS04865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWO_RS04885	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KWO_RS04930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KWO_RS04935	COG1404	Belongs to the peptidase S8 family
KWO_RS04940	COG1404	Belongs to the peptidase S8 family
KWO_RS04945	COG1404	Belongs to the peptidase S8 family
KWO_RS04950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KWO_RS04975	COG1295	ribonuclease BN
KWO_RS04980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KWO_RS05000	COG0521	Mo-molybdopterin cofactor biosynthetic process
KWO_RS05010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KWO_RS05015	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KWO_RS05025	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KWO_RS05030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KWO_RS05040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KWO_RS05045	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KWO_RS05050	COG0193	aminoacyl-tRNA hydrolase activity
KWO_RS05055	COG0012	GTP binding
KWO_RS05075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KWO_RS05090	COG0250	Participates in transcription elongation, termination and antitermination
KWO_RS05095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KWO_RS05100	COG0081	regulation of translation
KWO_RS05105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KWO_RS05115	COG0085	RNA polymerase activity
KWO_RS05120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KWO_RS05125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KWO_RS05130	COG0049	tRNA binding
KWO_RS05135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KWO_RS05140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KWO_RS05155	COG0051	transcription antitermination factor activity, RNA binding
KWO_RS05165	COG0088	Forms part of the polypeptide exit tunnel
KWO_RS05175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KWO_RS05185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KWO_RS05195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KWO_RS05200	COG0255	Belongs to the universal ribosomal protein uL29 family
KWO_RS05205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KWO_RS05215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KWO_RS05250	COG1841	ribosomal large subunit assembly
KWO_RS05255	COG0200	Binds to the 23S rRNA
KWO_RS05260	COG0201	protein transport
KWO_RS05285	COG0203	ribosomal protein L17
KWO_RS05290	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KWO_RS05305	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KWO_RS05320	COG0154	amidase activity
KWO_RS05330	COG1217	gtp-binding protein TYPA
KWO_RS05335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KWO_RS05345	COG0625	glutathione transferase activity
KWO_RS05365	COG1902	pentaerythritol trinitrate reductase activity
KWO_RS05365	COG0446	pyridine nucleotide-disulphide oxidoreductase
KWO_RS05370	COG0604	alcohol dehydrogenase
KWO_RS05375	COG2885	chlorophyll binding
KWO_RS05395	COG0156	8-amino-7-oxononanoate synthase activity
KWO_RS05400	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KWO_RS05405	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KWO_RS05410	COG4208	sulfate ABC transporter
KWO_RS05415	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KWO_RS05445	COG0406	alpha-ribazole phosphatase activity
KWO_RS05455	COG0285	dihydrofolate synthase activity
KWO_RS05475	COG2833	Protein of unknown function (DUF455)
KWO_RS05480	COG3291	Pkd domain containing protein
KWO_RS05490	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KWO_RS05495	COG0671	phosphoesterase, PA-phosphatase related
KWO_RS05500	COG0438	transferase activity, transferring glycosyl groups
KWO_RS05510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KWO_RS05525	COG4783	chaperone-mediated protein folding
KWO_RS05545	COG0473	3-isopropylmalate dehydrogenase activity
KWO_RS05590	COG0544	peptidyl-prolyl cis-trans isomerase activity
KWO_RS05600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KWO_RS05630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KWO_RS05645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KWO_RS05660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KWO_RS05670	COG0631	protein serine/threonine phosphatase activity
KWO_RS05690	COG0859	PFAM glycosyl transferase family 9
KWO_RS05695	COG3642	lipopolysaccharide core region biosynthetic process
KWO_RS05700	COG1234	tRNA 3'-trailer cleavage
KWO_RS05705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KWO_RS05715	COG0315	cyclic pyranopterin monophosphate synthase activity
KWO_RS05720	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KWO_RS05725	COG0314	molybdopterin synthase activity
KWO_RS05780	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KWO_RS05790	COG0537	adenosine 5'-monophosphoramidase activity
KWO_RS05810	COG0714	Associated with various cellular activities
KWO_RS05830	COG1399	metal-binding, possibly nucleic acid-binding protein
KWO_RS05840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KWO_RS05855	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS05860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KWO_RS05870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KWO_RS05875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KWO_RS05895	COG4115	mRNA cleavage
KWO_RS05910	COG3829	transcription factor binding
KWO_RS05930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KWO_RS05995	COG4221	oxidoreductase activity
KWO_RS06010	COG3039	Transposase
KWO_RS06065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KWO_RS06070	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KWO_RS06075	COG2080	2 iron, 2 sulfur cluster binding
KWO_RS06125	COG0587	DNA-directed DNA polymerase activity
KWO_RS06145	COG1297	OPT oligopeptide transporter protein
KWO_RS06160	COG1120	ATPase activity
KWO_RS06170	COG2255	four-way junction helicase activity
KWO_RS06175	COG0824	Thioesterase
KWO_RS06185	COG0848	biopolymer transport protein
KWO_RS06195	COG0823	Involved in the tonB-independent uptake of proteins
KWO_RS06200	COG2885	chlorophyll binding
KWO_RS06210	COG0602	queuosine metabolic process
KWO_RS06220	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KWO_RS06240	COG0840	transmembrane signaling receptor activity
KWO_RS06260	COG1187	pseudouridine synthase activity
KWO_RS06295	COG0514	ATP-dependent DNA helicase (RecQ)
KWO_RS06305	COG0783	Belongs to the Dps family
KWO_RS06310	COG1643	Atp-dependent helicase
KWO_RS06325	COG0837	glucose binding
KWO_RS06355	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
KWO_RS06360	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KWO_RS06370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KWO_RS06380	COG1215	transferase activity, transferring glycosyl groups
KWO_RS06390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KWO_RS06400	COG1199	ATP-dependent helicase activity
KWO_RS06410	COG1397	ADP-ribosylglycohydrolase
KWO_RS06420	COG0189	ligase activity
KWO_RS06435	COG0835	chemotaxis
KWO_RS06440	COG0840	transmembrane signaling receptor activity
KWO_RS06445	COG0784	Response regulator, receiver
KWO_RS06445	COG0643	Histidine kinase
KWO_RS06445	COG2198	Histidine kinase
KWO_RS06480	COG1446	asparaginase
KWO_RS06485	COG3142	Participates in the control of copper homeostasis
KWO_RS06525	COG3537	Alpha-1,2-mannosidase
KWO_RS06585	COG1472	Belongs to the glycosyl hydrolase 3 family
KWO_RS06625	COG1388	LysM domain
KWO_RS06625	COG3858	chitin binding
KWO_RS06650	COG0837	glucose binding
KWO_RS06655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KWO_RS06665	COG0494	nUDIX hydrolase
KWO_RS06675	COG3956	TIGRFAM MazG family protein
KWO_RS06680	COG1742	UPF0060 membrane protein
KWO_RS06685	COG0330	HflC and HflK could
KWO_RS06695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KWO_RS06700	COG0509	glycine decarboxylation via glycine cleavage system
KWO_RS06740	COG1960	acyl-CoA dehydrogenase activity
KWO_RS06745	COG2267	carboxylic ester hydrolase activity
KWO_RS06750	COG1309	transcriptional regulator
KWO_RS06755	COG4771	TonB-dependent receptor
KWO_RS06765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KWO_RS06775	COG0463	Glycosyl transferase, family 2
KWO_RS06785	COG2982	Protein involved in outer membrane biogenesis
KWO_RS06790	COG1272	protein, Hemolysin III
KWO_RS06795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KWO_RS06800	COG0739	heme binding
KWO_RS06805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KWO_RS06810	COG0626	cystathionine gamma-synthase activity
KWO_RS06815	COG0527	aspartate kinase activity
KWO_RS06815	COG0460	homoserine dehydrogenase
KWO_RS06825	COG1760	l-serine dehydratase
KWO_RS06855	COG2353	YceI-like domain
KWO_RS06860	COG0784	Response regulator, receiver
KWO_RS06860	COG2205	protein histidine kinase activity
KWO_RS06860	COG2198	Histidine kinase
KWO_RS06885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KWO_RS06900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KWO_RS06905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KWO_RS06910	COG0259	pyridoxamine-phosphate oxidase activity
KWO_RS06920	COG1842	Phage shock protein A
KWO_RS06945	COG0754	glutathionylspermidine amidase activity
KWO_RS06955	COG2814	Major facilitator Superfamily
KWO_RS07045	COG0531	amino acid
KWO_RS07050	COG2197	response regulator
KWO_RS07070	COG1113	amino acid transport
KWO_RS07080	COG1271	oxidase subunit
KWO_RS07085	COG1294	oxidase, subunit
KWO_RS07100	COG2239	Acts as a magnesium transporter
KWO_RS07110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KWO_RS07115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWO_RS07125	COG1660	Displays ATPase and GTPase activities
KWO_RS07135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWO_RS07150	COG1137	ATPase activity
KWO_RS07155	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KWO_RS07165	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KWO_RS07175	COG0271	Belongs to the BolA IbaG family
KWO_RS07180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KWO_RS07205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KWO_RS07215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KWO_RS07225	COG0628	permease
KWO_RS07235	COG3293	Transposase
KWO_RS07245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KWO_RS07250	COG3178	'Phosphotransferase
KWO_RS07260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KWO_RS07265	COG1555	photosystem II stabilization
KWO_RS07275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KWO_RS07280	COG1477	protein flavinylation
KWO_RS07305	COG3128	pkhd-type hydroxylase
KWO_RS07310	COG4774	siderophore transport
KWO_RS07315	COG2146	nitrite reductase [NAD(P)H] activity
KWO_RS07330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KWO_RS07335	COG0719	Fe-S assembly protein
KWO_RS07340	COG0396	ATPase activity
KWO_RS07345	COG0719	Fe-S assembly protein
KWO_RS07350	COG1959	2 iron, 2 sulfur cluster binding
KWO_RS07360	COG0693	protein deglycase activity
KWO_RS07385	COG4942	peptidase
KWO_RS07400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KWO_RS07425	COG0519	Catalyzes the synthesis of GMP from XMP
KWO_RS07430	COG1678	Uncharacterized ACR, COG1678
KWO_RS07435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KWO_RS07440	COG0540	Belongs to the ATCase OTCase family
KWO_RS07455	COG3039	Transposase
KWO_RS07465	COG1764	response to oxidative stress
KWO_RS07475	COG0384	phenazine biosynthesis protein PhzF
KWO_RS07480	COG0384	phenazine biosynthesis protein PhzF
KWO_RS07485	COG0527	aspartate kinase activity
KWO_RS07510	COG0142	geranyltranstransferase activity
KWO_RS07515	COG0629	single-stranded DNA binding
KWO_RS07520	COG5001	Diguanylate cyclase
KWO_RS07520	COG3706	GGDEF domain
KWO_RS07520	COG4251	negative regulation of phosphorylation
KWO_RS07520	COG2203	Gaf domain
KWO_RS07525	COG3321	synthase
KWO_RS07525	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS07525	COG0604	alcohol dehydrogenase
KWO_RS07530	COG2080	2 iron, 2 sulfur cluster binding
KWO_RS07535	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KWO_RS07540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KWO_RS07545	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KWO_RS07575	COG2879	small protein
KWO_RS07580	COG1966	Carbon starvation protein
KWO_RS07585	COG1741	Belongs to the pirin family
KWO_RS07605	COG1741	Belongs to the pirin family
KWO_RS07610	COG1515	deoxyribonuclease V activity
KWO_RS07615	COG0588	phosphoglycerate mutase activity
KWO_RS07635	COG1566	PFAM secretion protein HlyD family protein
KWO_RS07640	COG1136	(ABC) transporter
KWO_RS07645	COG1136	(ABC) transporter
KWO_RS07645	COG0577	efflux transmembrane transporter activity
KWO_RS07670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KWO_RS07680	COG0835	chemotaxis
KWO_RS07685	COG0840	transmembrane signaling receptor activity
KWO_RS07690	COG0643	Histidine kinase
KWO_RS07690	COG2198	Histidine kinase
KWO_RS07700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KWO_RS07710	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KWO_RS07715	COG0745	RESPONSE REGULATOR receiver
KWO_RS07725	COG2205	protein histidine kinase activity
KWO_RS07735	COG4452	Inner membrane protein CreD
KWO_RS07760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KWO_RS07765	COG0735	belongs to the Fur family
KWO_RS07785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KWO_RS07825	COG2207	Transcriptional regulator
KWO_RS07835	COG0583	DNA-binding transcription factor activity
KWO_RS07840	COG2814	Major facilitator Superfamily
KWO_RS07845	COG0667	Aldo Keto reductase
KWO_RS07905	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KWO_RS07955	COG5002	protein histidine kinase activity
KWO_RS07955	COG5001	Diguanylate cyclase
KWO_RS07960	COG1187	pseudouridine synthase activity
KWO_RS07985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KWO_RS07995	COG0475	glutathione-regulated potassium exporter activity
KWO_RS08000	COG5000	phosphorelay sensor kinase activity
KWO_RS08000	COG5002	protein histidine kinase activity
KWO_RS08005	COG0745	RESPONSE REGULATOR receiver
KWO_RS08010	COG1538	Outer membrane efflux protein
KWO_RS08035	COG1132	(ABC) transporter
KWO_RS08085	COG2155	Conserved Protein
KWO_RS08100	COG3118	belongs to the thioredoxin family
KWO_RS08125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KWO_RS08145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KWO_RS08160	COG2968	Membrane
KWO_RS08175	COG3164	Protein of unknown function
KWO_RS08185	COG0312	modulator of DNA gyrase
KWO_RS08195	COG0312	modulator of DNA gyrase
KWO_RS08210	COG0142	geranyltranstransferase activity
KWO_RS08215	COG1722	exodeoxyribonuclease VII activity
KWO_RS08220	COG0037	tRNA processing
KWO_RS08225	COG1785	Belongs to the alkaline phosphatase family
KWO_RS08230	COG1301	dicarboxylic acid transport
KWO_RS08245	COG0791	NLP P60 protein
KWO_RS08250	COG0791	NLP P60 protein
KWO_RS08255	COG1047	Peptidyl-prolyl cis-trans
KWO_RS08260	COG2311	Membrane
KWO_RS08265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KWO_RS08270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KWO_RS08290	COG3590	peptidase
KWO_RS08295	COG3590	peptidase
KWO_RS08325	COG0489	protein tyrosine kinase activity
KWO_RS08335	COG0717	Belongs to the dCTP deaminase family
KWO_RS08370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KWO_RS08380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KWO_RS08410	COG0433	COG0433 Predicted ATPase
KWO_RS08420	COG0688	phosphatidylethanolamine metabolic process
KWO_RS08425	COG0688	phosphatidylethanolamine metabolic process
KWO_RS08435	COG2890	protein-(glutamine-N5) methyltransferase activity
KWO_RS08440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KWO_RS08445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KWO_RS08450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KWO_RS08470	COG0101	tRNA pseudouridine synthase activity
KWO_RS08475	COG0135	phosphoribosylanthranilate isomerase activity
KWO_RS08485	COG0133	tryptophan synthase activity
KWO_RS08505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KWO_RS08510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KWO_RS08550	COG3293	Transposase
KWO_RS08565	COG0149	triose-phosphate isomerase activity
KWO_RS08580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KWO_RS08590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KWO_RS08595	COG0649	NAD binding
KWO_RS08600	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KWO_RS08605	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KWO_RS08610	COG1034	ATP synthesis coupled electron transport
KWO_RS08615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KWO_RS08620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KWO_RS08645	COG1007	ATP synthesis coupled electron transport
KWO_RS08655	COG0779	Required for maturation of 30S ribosomal subunits
KWO_RS08660	COG0195	Participates in both transcription termination and antitermination
KWO_RS08665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KWO_RS08670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KWO_RS08680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KWO_RS08685	COG1185	polyribonucleotide nucleotidyltransferase activity
KWO_RS08715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KWO_RS08720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KWO_RS08730	COG2095	MarC family integral membrane protein
KWO_RS08740	COG1611	Belongs to the LOG family
KWO_RS08745	COG3275	phosphorelay sensor kinase activity
KWO_RS08795	COG0556	nucleotide-excision repair
KWO_RS08810	COG3505	Type IV secretory pathway VirD4
KWO_RS08830	COG2948	multi-organism process
KWO_RS08850	COG3702	type iv secretory pathway
KWO_RS08930	COG0504	CTP synthase activity
KWO_RS08950	COG0148	phosphopyruvate hydratase activity
KWO_RS08955	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KWO_RS08965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KWO_RS08975	COG2840	Smr protein MutS2
KWO_RS08980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KWO_RS08985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KWO_RS08990	COG1238	metal cluster binding
KWO_RS09005	COG1534	Rna-binding protein
KWO_RS09010	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KWO_RS09020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KWO_RS09025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KWO_RS09035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KWO_RS09040	COG1546	Belongs to the CinA family
KWO_RS09055	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KWO_RS09060	COG2137	regulation of response to DNA damage stimulus
KWO_RS09065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KWO_RS09070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KWO_RS09090	COG1741	Belongs to the pirin family
KWO_RS09095	COG0583	DNA-binding transcription factor activity
KWO_RS09120	COG0351	phosphomethylpyrimidine kinase
KWO_RS09120	COG0352	thiamine-phosphate diphosphorylase activity
KWO_RS09135	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KWO_RS09140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KWO_RS09155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KWO_RS09165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KWO_RS09170	COG3734	2-keto-3-deoxy-galactonokinase
KWO_RS09180	COG4948	Mandelate Racemase Muconate Lactonizing
KWO_RS09185	COG0800	Aldolase
KWO_RS09255	COG1501	Belongs to the glycosyl hydrolase 31 family
KWO_RS09265	COG1070	Carbohydrate kinase
KWO_RS09275	COG0477	Major facilitator Superfamily
KWO_RS09295	COG1469	GTP cyclohydrolase I activity
KWO_RS09310	COG0617	tRNA 3'-terminal CCA addition
KWO_RS09320	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KWO_RS09325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KWO_RS09330	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KWO_RS09355	COG1472	Belongs to the glycosyl hydrolase 3 family
KWO_RS09385	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KWO_RS09390	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KWO_RS09400	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KWO_RS09405	COG0671	phosphoesterase, PA-phosphatase related
KWO_RS09420	COG1794	racemase activity, acting on amino acids and derivatives
KWO_RS09430	COG0697	spore germination
KWO_RS09435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KWO_RS09455	COG1012	belongs to the aldehyde dehydrogenase family
KWO_RS09495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KWO_RS09505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KWO_RS09510	COG0124	histidyl-tRNA synthetase
KWO_RS09520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KWO_RS09525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KWO_RS09530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KWO_RS09535	COG0131	Imidazoleglycerol-phosphate dehydratase
KWO_RS09535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KWO_RS09540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KWO_RS09545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KWO_RS09550	COG0107	imidazoleglycerol-phosphate synthase activity
KWO_RS09555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KWO_RS09555	COG0140	phosphoribosyl-ATP diphosphatase activity
KWO_RS09585	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KWO_RS09590	COG0235	Class ii aldolase
KWO_RS09595	COG0531	amino acid
KWO_RS09600	COG0531	amino acid
KWO_RS09610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KWO_RS09615	COG0277	FAD linked oxidase domain protein
KWO_RS09635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KWO_RS09680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KWO_RS09685	COG2258	MOSC domain
KWO_RS09690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KWO_RS09695	COG0505	Belongs to the CarA family
KWO_RS09705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KWO_RS09710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KWO_RS09720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KWO_RS09750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KWO_RS09760	COG2198	Histidine kinase
KWO_RS09760	COG2205	protein histidine kinase activity
KWO_RS09760	COG0784	Response regulator, receiver
KWO_RS09770	COG1024	Enoyl-CoA hydratase
KWO_RS09785	COG3039	Transposase
KWO_RS09795	COG0318	PFAM AMP-dependent synthetase and ligase
KWO_RS09825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KWO_RS09835	COG2201	protein-glutamate methylesterase activity
KWO_RS09840	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
KWO_RS09850	COG0840	transmembrane signaling receptor activity
KWO_RS09860	COG0835	chemotaxis
KWO_RS09870	COG0840	transmembrane signaling receptor activity
KWO_RS09875	COG0840	transmembrane signaling receptor activity
KWO_RS09880	COG0840	transmembrane signaling receptor activity
KWO_RS09885	COG0840	transmembrane signaling receptor activity
KWO_RS09890	COG0840	transmembrane signaling receptor activity
KWO_RS09895	COG0840	transmembrane signaling receptor activity
KWO_RS09900	COG0840	transmembrane signaling receptor activity
KWO_RS09905	COG0840	transmembrane signaling receptor activity
KWO_RS09910	COG0840	transmembrane signaling receptor activity
KWO_RS09920	COG0840	transmembrane signaling receptor activity
KWO_RS09940	COG0840	transmembrane signaling receptor activity
KWO_RS09950	COG0745	RESPONSE REGULATOR receiver
KWO_RS09960	COG0835	chemotaxis
KWO_RS09965	COG1192	Involved in chromosome partitioning
KWO_RS09970	COG1360	Flagellar Motor Protein
KWO_RS09975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KWO_RS10095	COG0643	Histidine kinase
KWO_RS10095	COG0784	Response regulator, receiver
KWO_RS10095	COG2198	Histidine kinase
KWO_RS10155	COG1684	flagellar biosynthetic protein fliR
KWO_RS10175	COG3190	flagellar
KWO_RS10225	COG1677	Flagellar hook-basal body complex protein FliE
KWO_RS10255	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS10260	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS10265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KWO_RS10285	COG2201	protein-glutamate methylesterase activity
KWO_RS10315	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KWO_RS10320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KWO_RS10340	COG1706	bacterial-type flagellum-dependent cell motility
KWO_RS10345	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KWO_RS10360	COG4787	bacterial-type flagellum-dependent cell motility
KWO_RS10370	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KWO_RS10385	COG0784	Response regulator, receiver
KWO_RS10385	COG0835	chemotaxis
KWO_RS10410	COG5002	protein histidine kinase activity
KWO_RS10420	COG4585	Histidine kinase
KWO_RS10450	COG0482	sulfurtransferase activity
KWO_RS10465	COG0542	response to heat
KWO_RS10475	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KWO_RS10485	COG0492	ferredoxin-NADP+ reductase activity
KWO_RS10490	COG1674	ftsk spoiiie
KWO_RS10510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KWO_RS10515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KWO_RS10520	COG0183	Belongs to the thiolase family
KWO_RS10525	COG1024	Enoyl-CoA hydratase
KWO_RS10525	COG1250	3-hydroxyacyl-CoA dehydrogenase
KWO_RS10540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KWO_RS10560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KWO_RS10565	COG1160	GTP binding
KWO_RS10575	COG0303	'Molybdopterin
KWO_RS10580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KWO_RS10595	COG2124	cytochrome p450
KWO_RS10620	COG0708	Exodeoxyribonuclease III
KWO_RS10625	COG0303	'Molybdopterin
KWO_RS10630	COG0746	molybdenum cofactor guanylyltransferase activity
KWO_RS10640	COG1648	precorrin-2 dehydrogenase activity
KWO_RS10640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KWO_RS10665	COG3685	Protein conserved in bacteria
KWO_RS10680	COG5001	Diguanylate cyclase
KWO_RS10700	COG4566	intracellular signal transduction
KWO_RS10765	COG2801	Transposase and inactivated derivatives
KWO_RS10860	COG0631	protein serine/threonine phosphatase activity
KWO_RS10865	COG0515	serine threonine protein kinase
KWO_RS10895	COG1858	cytochrome C peroxidase
KWO_RS11030	COG2154	pterin-4-alpha-carbinolamine dehydratase
KWO_RS11045	COG0428	transporter
KWO_RS11050	COG3064	Membrane
KWO_RS11060	COG1530	ribonuclease E activity
KWO_RS11075	COG1054	Belongs to the UPF0176 family
KWO_RS11095	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KWO_RS11120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KWO_RS11125	COG0322	excinuclease ABC activity
KWO_RS11135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KWO_RS11140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KWO_RS11145	COG1663	tetraacyldisaccharide 4'-kinase activity
KWO_RS11150	COG1132	(ABC) transporter
KWO_RS11160	COG0811	peptide transport
KWO_RS11180	COG4591	ABC-type transport system involved in lipoprotein release permease component
KWO_RS11190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KWO_RS11195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KWO_RS11210	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KWO_RS11240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KWO_RS11245	COG0837	glucose binding
KWO_RS11250	COG0363	glucosamine-6-phosphate deaminase activity
KWO_RS11255	COG0129	dihydroxy-acid dehydratase activity
KWO_RS11260	COG0800	Aldolase
KWO_RS11335	COG0784	Response regulator, receiver
KWO_RS11335	COG2205	protein histidine kinase activity
KWO_RS11345	COG2183	response to ionizing radiation
KWO_RS11355	COG0723	plastoquinol--plastocyanin reductase activity
KWO_RS11355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KWO_RS11370	COG3243	poly(R)-hydroxyalkanoic acid synthase
KWO_RS11380	COG1183	phosphatidylcholine synthase activity
KWO_RS11385	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS11400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KWO_RS11410	COG0668	transmembrane transport
KWO_RS11415	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KWO_RS11430	COG1914	H( )-stimulated, divalent metal cation uptake system
KWO_RS11445	COG2814	Major facilitator Superfamily
KWO_RS11475	COG2197	response regulator
KWO_RS11490	COG0583	DNA-binding transcription factor activity
KWO_RS11500	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS11515	COG0583	DNA-binding transcription factor activity
KWO_RS11520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KWO_RS11525	COG3002	Belongs to the UPF0753 family
KWO_RS11540	COG1196	nuclear chromosome segregation
KWO_RS11545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KWO_RS11555	COG1002	Type II restriction enzyme, methylase subunits
KWO_RS11600	COG1487	ribonuclease activity
KWO_RS11605	COG4691	Plasmid stability protein
KWO_RS11635	COG0582	viral genome integration into host DNA
KWO_RS11655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KWO_RS11670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KWO_RS11685	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KWO_RS11695	COG0776	regulation of translation
KWO_RS11700	COG0539	negative regulation of cytoplasmic translation
KWO_RS11705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KWO_RS11725	COG2957	Belongs to the agmatine deiminase family
KWO_RS11735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KWO_RS11760	COG0395	ABC-type sugar transport system, permease component
KWO_RS11765	COG1175	transmembrane transport
KWO_RS11795	COG2350	Protein conserved in bacteria
KWO_RS11800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KWO_RS11805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KWO_RS11810	COG1187	pseudouridine synthase activity
KWO_RS11835	COG0436	Aminotransferase
KWO_RS11840	COG4133	protoheme IX ABC transporter activity
KWO_RS11860	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KWO_RS11885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KWO_RS11890	COG1278	Cold shock
KWO_RS11900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KWO_RS11905	COG4988	ABC transporter
KWO_RS11960	COG0165	Argininosuccinate lyase
KWO_RS11965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KWO_RS11975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KWO_RS11980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KWO_RS11990	COG0137	argininosuccinate synthase activity
KWO_RS11995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KWO_RS12010	COG2166	iron-sulfur cluster assembly
KWO_RS12030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KWO_RS12035	COG0739	heme binding
KWO_RS12045	COG4302	ethanolamine ammonia-lyase activity
KWO_RS12080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KWO_RS12085	COG0402	S-adenosylhomocysteine deaminase activity
KWO_RS12100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KWO_RS12105	COG1509	lysine 2,3-aminomutase activity
KWO_RS12115	COG5001	Diguanylate cyclase
KWO_RS12115	COG3300	MHYT domain
KWO_RS12130	COG0483	inositol monophosphate 1-phosphatase activity
KWO_RS12135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KWO_RS12155	COG0488	(ABC) transporter
KWO_RS12160	COG0513	Belongs to the DEAD box helicase family
KWO_RS12170	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KWO_RS12180	COG0625	glutathione transferase activity
KWO_RS12190	COG1671	Belongs to the UPF0178 family
KWO_RS12210	COG0501	Belongs to the peptidase M48B family
KWO_RS12220	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS12245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KWO_RS12250	COG0860	N-Acetylmuramoyl-L-alanine amidase
KWO_RS12255	COG0802	atpase or kinase
KWO_RS12260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KWO_RS12260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KWO_RS12265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KWO_RS12280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KWO_RS12330	COG0835	chemotaxis
KWO_RS12335	COG0840	transmembrane signaling receptor activity
KWO_RS12340	COG2094	Belongs to the DNA glycosylase MPG family
KWO_RS12345	COG1201	RNA secondary structure unwinding
KWO_RS12350	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
KWO_RS12370	COG2969	positive regulation of protein catabolic process
KWO_RS12375	COG0625	glutathione transferase activity
KWO_RS12380	COG2857	Cytochrome c1
KWO_RS12385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KWO_RS12390	COG0723	plastoquinol--plastocyanin reductase activity
KWO_RS12395	COG0741	lytic transglycosylase activity
KWO_RS12425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KWO_RS12440	COG4535	Mg2 and Co2 transporter CorC
KWO_RS12455	COG1012	belongs to the aldehyde dehydrogenase family
KWO_RS12460	COG1177	transmembrane transport
KWO_RS12465	COG1176	ABC-type spermidine putrescine transport system, permease component I
KWO_RS12475	COG3842	ATPase activity
KWO_RS12495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KWO_RS12515	COG0174	glutamine synthetase
KWO_RS12520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KWO_RS12530	COG0477	Major facilitator Superfamily
KWO_RS12550	COG0243	molybdopterin cofactor binding
KWO_RS12555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KWO_RS12560	COG2223	nitrite transmembrane transporter activity
KWO_RS12570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KWO_RS12575	COG1121	(ABC) transporter
KWO_RS12585	COG2733	membrane
KWO_RS12605	COG0477	Major facilitator Superfamily
KWO_RS12610	COG2902	Dehydrogenase
KWO_RS12620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KWO_RS12625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KWO_RS12660	COG3039	Transposase
KWO_RS12675	COG1609	Transcriptional regulator
KWO_RS12680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWO_RS12680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KWO_RS12685	COG1105	Belongs to the carbohydrate kinase PfkB family
KWO_RS12690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KWO_RS12690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KWO_RS12730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KWO_RS12740	COG1862	Preprotein translocase
KWO_RS12745	COG0343	queuine tRNA-ribosyltransferase activity
KWO_RS12750	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KWO_RS12795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KWO_RS12800	COG3291	Pkd domain containing protein
KWO_RS12815	COG0405	Gamma-glutamyltransferase
KWO_RS12820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KWO_RS12835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KWO_RS12840	COG0742	ribosomal rna small subunit methyltransferase
KWO_RS12845	COG0326	Molecular chaperone. Has ATPase activity
KWO_RS12880	COG4206	TonB-dependent receptor
KWO_RS12950	COG0531	amino acid
KWO_RS12965	COG0006	proline dipeptidase activity
KWO_RS12975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KWO_RS12990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KWO_RS12995	COG3938	Belongs to the proline racemase family
KWO_RS13005	COG0552	protein localization to endoplasmic reticulum
KWO_RS13025	COG4191	Histidine kinase
KWO_RS13025	COG0784	Response regulator, receiver
KWO_RS13035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KWO_RS13060	COG3040	lipid binding
KWO_RS13070	COG1960	acyl-CoA dehydrogenase activity
KWO_RS13080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KWO_RS13100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KWO_RS13105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KWO_RS13110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KWO_RS13135	COG0438	transferase activity, transferring glycosyl groups
KWO_RS13145	COG0438	transferase activity, transferring glycosyl groups
KWO_RS13150	COG0438	transferase activity, transferring glycosyl groups
KWO_RS13205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KWO_RS13220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KWO_RS13225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KWO_RS13235	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KWO_RS13240	COG0306	phosphate transporter
KWO_RS13255	COG1253	flavin adenine dinucleotide binding
KWO_RS13270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KWO_RS13280	COG0477	Major facilitator Superfamily
KWO_RS13285	COG1132	(ABC) transporter
KWO_RS13290	COG1136	(ABC) transporter
KWO_RS13305	COG0438	transferase activity, transferring glycosyl groups
KWO_RS13320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KWO_RS13345	COG2244	polysaccharide biosynthetic process
KWO_RS13415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KWO_RS13425	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KWO_RS13435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KWO_RS13450	COG0784	Response regulator, receiver
KWO_RS13450	COG4191	Histidine kinase
KWO_RS13455	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KWO_RS13460	COG2205	protein histidine kinase activity
KWO_RS13460	COG0784	Response regulator, receiver
KWO_RS13460	COG5002	protein histidine kinase activity
KWO_RS13490	COG0840	transmembrane signaling receptor activity
KWO_RS13530	COG0583	DNA-binding transcription factor activity
KWO_RS13535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KWO_RS13540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KWO_RS13555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KWO_RS13560	COG1605	Chorismate mutase
KWO_RS13560	COG0077	Prephenate dehydratase
KWO_RS13565	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KWO_RS13570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KWO_RS13575	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
KWO_RS13610	COG1228	amidohydrolase
KWO_RS13615	COG2986	histidine ammonia-lyase
KWO_RS13625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KWO_RS13650	COG4993	Dehydrogenase
KWO_RS13660	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KWO_RS13675	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KWO_RS13680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KWO_RS13685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KWO_RS13695	COG3115	cell septum assembly
KWO_RS13715	COG0360	Binds together with S18 to 16S ribosomal RNA
KWO_RS13720	COG0316	Belongs to the HesB IscA family
KWO_RS13730	COG0017	Asparaginyl-tRNA synthetase
KWO_RS13750	COG2808	Putative FMN-binding domain
KWO_RS13755	COG0288	reversible hydration of carbon dioxide
KWO_RS13770	COG3844	kynureninase activity
KWO_RS13775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KWO_RS13780	COG2925	Exonuclease
KWO_RS13790	COG0667	Aldo Keto reductase
KWO_RS13810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KWO_RS13815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KWO_RS13815	COG0116	Belongs to the methyltransferase superfamily
KWO_RS13825	COG0488	(ABC) transporter
KWO_RS13860	COG0494	nUDIX hydrolase
KWO_RS13870	COG1024	Enoyl-CoA hydratase
KWO_RS13880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KWO_RS13890	COG0659	secondary active sulfate transmembrane transporter activity
KWO_RS13920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KWO_RS13925	COG0573	inorganic phosphate transmembrane transporter activity
KWO_RS13930	COG0581	inorganic phosphate transmembrane transporter activity
KWO_RS13935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KWO_RS13940	COG0704	Plays a role in the regulation of phosphate uptake
KWO_RS13950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KWO_RS13960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KWO_RS13970	COG0557	exoribonuclease II activity
KWO_RS13985	COG1960	acyl-CoA dehydrogenase activity
KWO_RS13990	COG2226	methyltransferase
KWO_RS13995	COG1410	methionine synthase
KWO_RS13995	COG0646	methionine synthase
KWO_RS14010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KWO_RS14035	COG2900	Belongs to the SlyX family
KWO_RS14050	COG0386	Belongs to the glutathione peroxidase family
KWO_RS14060	COG1725	Transcriptional regulator
KWO_RS14065	COG1131	(ABC) transporter
KWO_RS14095	COG1253	flavin adenine dinucleotide binding
KWO_RS14130	COG2850	peptidyl-arginine hydroxylation
KWO_RS14165	COG1132	(ABC) transporter
KWO_RS14175	COG0583	DNA-binding transcription factor activity
KWO_RS14210	COG0484	heat shock protein binding
KWO_RS14215	COG0443	Heat shock 70 kDa protein
KWO_RS14220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KWO_RS14225	COG1420	regulation of RNA biosynthetic process
KWO_RS14230	COG0497	DNA recombination
KWO_RS14240	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KWO_RS14250	COG2914	Belongs to the UPF0125 (RnfH) family
KWO_RS14260	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KWO_RS14295	COG3706	GGDEF domain
KWO_RS14340	COG0583	DNA-binding transcription factor activity
KWO_RS14355	COG0415	Belongs to the DNA photolyase family
KWO_RS14360	COG0305	Participates in initiation and elongation during chromosome replication
KWO_RS14370	COG0367	asparagine synthase
KWO_RS14390	COG1960	acyl-CoA dehydrogenase activity
KWO_RS14410	COG0084	hydrolase, TatD family'
KWO_RS14415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KWO_RS14475	COG0386	Belongs to the glutathione peroxidase family
KWO_RS14485	COG0339	signal peptide processing
KWO_RS14560	COG2814	Major facilitator Superfamily
KWO_RS14565	COG1566	PFAM secretion protein HlyD family protein
KWO_RS14580	COG2207	Transcriptional regulator
KWO_RS14595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KWO_RS14615	COG4774	siderophore transport
KWO_RS14625	COG0367	asparagine synthase
KWO_RS14630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KWO_RS14640	COG1393	Belongs to the ArsC family
KWO_RS14655	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KWO_RS14700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KWO_RS14710	COG0528	UMP kinase activity
KWO_RS14715	COG0233	cytoplasmic translational termination
KWO_RS14730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KWO_RS14735	COG0750	zinc metalloprotease
KWO_RS14750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KWO_RS14755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KWO_RS14760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KWO_RS14765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KWO_RS14770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KWO_RS14785	COG0825	malonyl-CoA metabolic process
KWO_RS14800	COG1981	membrane
KWO_RS14845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KWO_RS14855	COG2040	homocysteine
KWO_RS14860	COG0833	amino acid
KWO_RS14865	COG0346	lactoylglutathione lyase activity
KWO_RS14875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KWO_RS14875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KWO_RS14885	COG2878	Part of a membrane complex involved in electron transport
KWO_RS14905	COG1595	DNA-templated transcription, initiation
KWO_RS14930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KWO_RS14945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KWO_RS14950	COG0251	oxidation-reduction process
KWO_RS14960	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KWO_RS14960	COG0392	lysyltransferase activity
KWO_RS14995	COG2814	Major facilitator Superfamily
KWO_RS15000	COG1902	pentaerythritol trinitrate reductase activity
KWO_RS15015	COG2824	Alkylphosphonate utilization operon protein PhnA
KWO_RS15030	COG1047	Peptidyl-prolyl cis-trans
KWO_RS15065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KWO_RS15075	COG5487	UPF0391 membrane protein
KWO_RS15085	COG1451	nucleotide metabolic process
KWO_RS15105	COG0183	Belongs to the thiolase family
KWO_RS15120	COG5001	Diguanylate cyclase
KWO_RS15135	COG1793	dna ligase
KWO_RS15135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KWO_RS15145	COG1793	dna ligase
KWO_RS15165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KWO_RS15170	COG1278	Cold shock
KWO_RS15175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KWO_RS15180	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KWO_RS15185	COG1472	Belongs to the glycosyl hydrolase 3 family
KWO_RS15190	COG3046	protein related to deoxyribodipyrimidine photolyase
KWO_RS15195	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
KWO_RS15200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KWO_RS15205	COG2954	triphosphatase activity
KWO_RS15220	COG1381	Involved in DNA repair and RecF pathway recombination
KWO_RS15225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KWO_RS15230	COG0571	ribonuclease III activity
KWO_RS15250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KWO_RS15265	COG1250	3-hydroxyacyl-CoA dehydrogenase
KWO_RS15265	COG1024	Enoyl-CoA hydratase
KWO_RS15290	COG1024	Enoyl-CoA hydratase
KWO_RS15295	COG1960	acyl-CoA dehydrogenase activity
KWO_RS15315	COG3867	Arabinogalactan endo-beta-1,4-galactanase
KWO_RS15320	COG3250	beta-galactosidase activity
KWO_RS15335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KWO_RS15350	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS15355	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS15360	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS15370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KWO_RS15380	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KWO_RS15390	COG0534	Mate efflux family protein
KWO_RS15400	COG0336	Belongs to the RNA methyltransferase TrmD family
KWO_RS15405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KWO_RS15410	COG0228	four-way junction DNA binding
KWO_RS15415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KWO_RS15420	COG2070	2-Nitropropane dioxygenase
KWO_RS15430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KWO_RS15435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KWO_RS15455	COG4191	Histidine kinase
KWO_RS15455	COG0784	Response regulator, receiver
KWO_RS15460	COG2205	protein histidine kinase activity
KWO_RS15460	COG4999	Histidine kinase
KWO_RS15460	COG3850	Histidine kinase
KWO_RS15460	COG3437	response regulator, receiver
KWO_RS15465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KWO_RS15475	COG2205	protein histidine kinase activity
KWO_RS15480	COG5507	3-demethylubiquinone-9 3-methyltransferase
KWO_RS15515	COG2172	sigma factor antagonist activity
KWO_RS15520	COG1366	Belongs to the anti-sigma-factor antagonist family
KWO_RS15525	COG1366	Belongs to the anti-sigma-factor antagonist family
KWO_RS15535	COG0326	Molecular chaperone. Has ATPase activity
KWO_RS15540	COG2207	Transcriptional regulator
KWO_RS15555	COG3152	Membrane
KWO_RS15570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KWO_RS15575	COG1845	cytochrome c oxidase, subunit III
KWO_RS15580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KWO_RS15600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KWO_RS15605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KWO_RS15610	COG0196	riboflavin kinase activity
KWO_RS15615	COG0728	peptidoglycan biosynthetic process
KWO_RS15620	COG0268	Binds directly to 16S ribosomal RNA
KWO_RS15625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KWO_RS15630	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KWO_RS15635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KWO_RS15640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KWO_RS15645	COG0824	Thioesterase
KWO_RS15660	COG1946	Acyl-CoA thioesterase
KWO_RS15690	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KWO_RS15705	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KWO_RS15735	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KWO_RS15750	COG2197	response regulator
KWO_RS15755	COG4585	Histidine kinase
KWO_RS15770	COG0850	regulation of cytokinetic process
KWO_RS15775	COG2894	cell division
KWO_RS15780	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KWO_RS15790	COG0642	Histidine kinase
KWO_RS15795	COG0745	RESPONSE REGULATOR receiver
KWO_RS15810	COG2194	sulfuric ester hydrolase activity
KWO_RS15825	COG2814	Major facilitator Superfamily
KWO_RS15850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KWO_RS15850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KWO_RS15860	COG0656	L-ascorbic acid biosynthetic process
KWO_RS15865	COG0753	catalase activity
KWO_RS15940	COG1917	Cupin 2, conserved barrel domain protein
KWO_RS15940	COG2207	Transcriptional regulator
KWO_RS15950	COG0823	Involved in the tonB-independent uptake of proteins
KWO_RS15950	COG1506	peptidase
KWO_RS16000	COG0477	Major facilitator Superfamily
KWO_RS16020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KWO_RS16040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KWO_RS16050	COG3158	transport of potassium into the cell
KWO_RS16080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KWO_RS16125	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
KWO_RS16170	COG0308	aminopeptidase N
KWO_RS16180	COG0330	HflC and HflK could
KWO_RS16185	COG0330	HflC and HflK could
KWO_RS16205	COG0678	peroxiredoxin activity
KWO_RS16215	COG4953	penicillin-binding protein 1C
KWO_RS16235	COG2373	Large extracellular alpha-helical protein
KWO_RS16290	COG0488	(ABC) transporter
KWO_RS16330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KWO_RS16330	COG4651	solute:proton antiporter activity
KWO_RS16340	COG4772	TonB-dependent receptor
KWO_RS16350	COG4264	IucA IucC family
KWO_RS16355	COG2814	Major facilitator Superfamily
KWO_RS16365	COG0019	diaminopimelate decarboxylase activity
KWO_RS16405	COG0542	response to heat
KWO_RS16410	COG1116	anion transmembrane transporter activity
KWO_RS16415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KWO_RS16420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KWO_RS16425	COG0667	Aldo Keto reductase
KWO_RS16430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KWO_RS16435	COG4771	TonB-dependent receptor
KWO_RS16440	COG2827	Endonuclease containing a URI domain
KWO_RS16490	COG1877	trehalose-phosphatase activity
KWO_RS16495	COG3387	PFAM Glycoside hydrolase 15-related
KWO_RS16510	COG0840	transmembrane signaling receptor activity
KWO_RS16515	COG3011	Protein conserved in bacteria
KWO_RS16530	COG0564	pseudouridine synthase activity
KWO_RS16535	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KWO_RS16540	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KWO_RS16540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KWO_RS16555	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KWO_RS16560	COG0045	succinate-CoA ligase (ADP-forming) activity
KWO_RS16595	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KWO_RS16600	COG0237	dephospho-CoA kinase activity
KWO_RS16640	COG0745	RESPONSE REGULATOR receiver
KWO_RS16700	COG0519	Catalyzes the synthesis of GMP from XMP
KWO_RS16700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KWO_RS16710	COG0805	protein transport
KWO_RS16715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KWO_RS16720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KWO_RS16730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KWO_RS16750	COG2974	May be involved in recombination
KWO_RS16755	COG0037	tRNA processing
KWO_RS16775	COG3661	Belongs to the glycosyl hydrolase 67 family
KWO_RS16785	COG4948	Mandelate Racemase Muconate Lactonizing
KWO_RS16795	COG1472	Belongs to the glycosyl hydrolase 3 family
KWO_RS16800	COG0246	Mannitol dehydrogenase
KWO_RS16870	COG3386	PFAM SMP-30 Gluconolaconase
KWO_RS16910	COG1904	glucuronate isomerase
KWO_RS16915	COG3693	PFAM glycoside hydrolase, family 10
KWO_RS16935	COG2211	Major facilitator Superfamily
KWO_RS16975	COG2937	Belongs to the GPAT DAPAT family
KWO_RS17005	COG0284	orotidine-5'-phosphate decarboxylase activity
KWO_RS17010	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KWO_RS17030	COG0210	DNA helicase
KWO_RS17035	COG1435	thymidine kinase activity
KWO_RS17045	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
KWO_RS17055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KWO_RS17090	COG0739	heme binding
KWO_RS17105	COG2211	Major facilitator Superfamily
KWO_RS17110	COG0708	Exodeoxyribonuclease III
KWO_RS17125	COG1192	Involved in chromosome partitioning
KWO_RS17130	COG1475	DNA binding
KWO_RS17150	COG0463	Glycosyl transferase, family 2
KWO_RS17175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KWO_RS17185	COG0018	arginyl-trna synthetase
KWO_RS17200	COG4221	oxidoreductase activity
KWO_RS17215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KWO_RS17220	COG1166	arginine decarboxylase activity
KWO_RS17225	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KWO_RS17255	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KWO_RS17255	COG3291	Pkd domain containing protein
KWO_RS17270	COG0606	chelatase, subunit chli
KWO_RS17285	COG4943	cyclic-guanylate-specific phosphodiesterase activity
KWO_RS17320	COG1690	Belongs to the RtcB family
KWO_RS17355	COG1090	epimerase
KWO_RS17365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KWO_RS17385	COG0628	permease
KWO_RS17390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KWO_RS17395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KWO_RS17405	COG1595	DNA-templated transcription, initiation
KWO_RS17410	COG0753	catalase activity
KWO_RS17425	COG2197	response regulator
KWO_RS17430	COG4585	Histidine kinase
KWO_RS17435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KWO_RS17440	COG1136	(ABC) transporter
KWO_RS17465	COG0697	spore germination
KWO_RS17490	COG0180	Tryptophanyl-tRNA synthetase
KWO_RS17495	COG3237	CsbD-like
KWO_RS17540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KWO_RS17555	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KWO_RS17560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KWO_RS17560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KWO_RS17575	COG3228	Belongs to the MtfA family
KWO_RS17605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KWO_RS17640	COG1199	ATP-dependent helicase activity
KWO_RS17655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KWO_RS17670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KWO_RS17735	COG0625	glutathione transferase activity
KWO_RS17770	COG4555	ABC transporter
KWO_RS17785	COG1476	TRANSCRIPTIONal
KWO_RS17805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KWO_RS17810	COG1131	(ABC) transporter
KWO_RS17815	COG0842	Transport permease protein
KWO_RS17825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KWO_RS17860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KWO_RS17875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KWO_RS17885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KWO_RS17900	COG1042	CoA-binding domain protein
KWO_RS17900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KWO_RS17900	COG0045	succinate-CoA ligase (ADP-forming) activity
KWO_RS17910	COG2239	Acts as a magnesium transporter
KWO_RS17925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KWO_RS17930	COG3387	PFAM Glycoside hydrolase 15-related
KWO_RS17945	COG3100	YcgL domain-containing protein
KWO_RS17950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KWO_RS17960	COG0463	Glycosyl transferase, family 2
KWO_RS17975	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS18000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KWO_RS18015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KWO_RS18080	COG1121	(ABC) transporter
KWO_RS18130	COG0408	coproporphyrinogen oxidase activity
KWO_RS18145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KWO_RS18230	COG0210	DNA helicase
KWO_RS18245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KWO_RS18255	COG2159	amidohydrolase
KWO_RS18280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KWO_RS18305	COG0357	Ribosomal RNA small subunit methyltransferase G
KWO_RS18320	COG2091	lysine biosynthetic process via aminoadipic acid
KWO_RS18335	COG0708	Exodeoxyribonuclease III
KWO_RS18340	COG1940	carbohydrate kinase activity
KWO_RS18350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KWO_RS18360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KWO_RS18365	COG3162	membrane
KWO_RS18425	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS18430	COG0179	Fumarylacetoacetate (FAA) hydrolase
KWO_RS18435	COG4948	Mandelate Racemase Muconate Lactonizing
KWO_RS18440	COG3254	rhamnose metabolic process
KWO_RS18445	COG0738	Major facilitator superfamily
KWO_RS18450	COG1414	Transcriptional regulator
KWO_RS18465	COG2205	protein histidine kinase activity
KWO_RS18475	COG3459	Glycosyltransferase 36 associated
KWO_RS18480	COG2211	Major facilitator Superfamily
KWO_RS18485	COG3265	gluconokinase activity
KWO_RS18525	COG2911	Protein conserved in bacteria
KWO_RS18530	COG0729	surface antigen
KWO_RS18545	COG3293	Transposase
KWO_RS18555	COG4771	TonB-dependent receptor
KWO_RS18560	COG0457	Tetratricopeptide repeat
KWO_RS18570	COG0752	glycyl-tRNA synthetase alpha subunit
KWO_RS18575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KWO_RS18610	COG2022	thiamine diphosphate biosynthetic process
KWO_RS18615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KWO_RS18620	COG0471	metal ion transport
KWO_RS18620	COG3273	potassium ion transport
KWO_RS18640	COG1970	mechanosensitive ion channel activity
KWO_RS18650	COG1609	Transcriptional regulator
KWO_RS18675	COG3250	beta-galactosidase activity
KWO_RS18680	COG4948	Mandelate Racemase Muconate Lactonizing
KWO_RS18700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KWO_RS18715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KWO_RS18725	COG0529	Catalyzes the synthesis of activated sulfate
KWO_RS18725	COG2895	sulfate adenylyltransferase (ATP) activity
KWO_RS18730	COG0175	sulfate reduction
KWO_RS18735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KWO_RS18740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KWO_RS18745	COG0175	sulfate reduction
KWO_RS18765	COG0784	Response regulator, receiver
KWO_RS18765	COG2205	protein histidine kinase activity
KWO_RS18765	COG2198	Histidine kinase
KWO_RS18780	COG0583	DNA-binding transcription factor activity
KWO_RS18800	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KWO_RS18805	COG3588	fructose-bisphosphate aldolase
KWO_RS18815	COG0469	pyruvate kinase activity
KWO_RS18850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KWO_RS18870	COG3047	cAMP biosynthetic process
KWO_RS18880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KWO_RS18880	COG3453	Protein conserved in bacteria
KWO_RS18885	COG0725	ABC transporter, periplasmic molybdate-binding protein
KWO_RS18890	COG4149	molybdate abc transporter
KWO_RS18915	COG1376	ErfK ybiS ycfS ynhG family protein
KWO_RS18920	COG0739	heme binding
KWO_RS18925	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS18930	COG0583	DNA-binding transcription factor activity
KWO_RS18945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KWO_RS18950	COG1301	dicarboxylic acid transport
KWO_RS18965	COG2304	oxidoreductase activity
KWO_RS18985	COG0714	Associated with various cellular activities
KWO_RS19015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KWO_RS19040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KWO_RS19050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KWO_RS19065	COG1561	YicC-like family, N-terminal region
KWO_RS19070	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KWO_RS19085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KWO_RS19100	COG0006	proline dipeptidase activity
KWO_RS19110	COG0006	proline dipeptidase activity
KWO_RS19135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KWO_RS19155	COG2912	Transglutaminase-like superfamily
KWO_RS19160	COG1773	rubredoxin
KWO_RS19165	COG0352	thiamine-phosphate diphosphorylase activity
KWO_RS19180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KWO_RS19190	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
KWO_RS19195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KWO_RS19225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KWO_RS19230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KWO_RS19240	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS19250	COG0671	phosphoesterase, PA-phosphatase related
KWO_RS19255	COG3781	membrane
KWO_RS19265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KWO_RS19285	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KWO_RS19295	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KWO_RS19315	COG3710	Transcriptional regulator
KWO_RS19320	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KWO_RS19335	COG0840	transmembrane signaling receptor activity
KWO_RS19345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KWO_RS19365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KWO_RS19370	COG0473	3-isopropylmalate dehydrogenase activity
KWO_RS19375	COG2226	methyltransferase
KWO_RS19380	COG0066	3-isopropylmalate dehydratase activity
KWO_RS19385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KWO_RS19415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KWO_RS19420	COG1538	Outer membrane efflux protein
KWO_RS19425	COG1519	Transferase
KWO_RS19430	COG1560	Kdo2-lipid A biosynthetic process
KWO_RS19525	COG0281	malic enzyme
KWO_RS19525	COG0280	phosphate acetyltransferase
KWO_RS19530	COG1301	dicarboxylic acid transport
KWO_RS19540	COG4191	Histidine kinase
KWO_RS19555	COG0583	DNA-binding transcription factor activity
KWO_RS19560	COG0667	Aldo Keto reductase
KWO_RS19575	COG2197	response regulator
KWO_RS19585	COG0642	Histidine kinase
KWO_RS19610	COG2851	Citrate transporter
KWO_RS19615	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS19620	COG1609	Transcriptional regulator
KWO_RS19630	COG2211	Major facilitator Superfamily
KWO_RS19655	COG1162	GTPase activity
KWO_RS19660	COG0436	Aminotransferase
KWO_RS19680	COG0726	polysaccharide deacetylase
KWO_RS19685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KWO_RS19700	COG3964	amidohydrolase
KWO_RS19760	COG3791	Glutathione-dependent formaldehyde-activating
KWO_RS19785	COG2205	protein histidine kinase activity
KWO_RS19810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KWO_RS19825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KWO_RS19845	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KWO_RS19850	COG0456	acetyltransferase
KWO_RS19860	COG1183	phosphatidylcholine synthase activity
KWO_RS19870	COG0442	prolyl-tRNA aminoacylation
KWO_RS19885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KWO_RS19890	COG1127	ABC transporter
KWO_RS19895	COG3218	ABC-type transport auxiliary lipoprotein component
KWO_RS19895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KWO_RS19935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KWO_RS19940	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KWO_RS19940	COG0662	Cupin 2, conserved barrel domain protein
KWO_RS19965	COG2086	electron transfer activity
KWO_RS19980	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KWO_RS19980	COG0546	phosphoglycolate phosphatase activity
KWO_RS19985	COG0277	FAD linked oxidase domain protein
KWO_RS20000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KWO_RS20030	COG1216	Glycosyl transferase, family 2
KWO_RS20030	COG0438	transferase activity, transferring glycosyl groups
KWO_RS20050	COG0626	cystathionine gamma-synthase activity
KWO_RS20080	COG0625	glutathione transferase activity
KWO_RS20095	COG0513	Belongs to the DEAD box helicase family
KWO_RS20105	COG0720	synthase
KWO_RS20115	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KWO_RS20120	COG1956	GAF domain-containing protein
KWO_RS20130	COG0546	phosphoglycolate phosphatase activity
KWO_RS20135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KWO_RS20160	COG0339	signal peptide processing
KWO_RS20210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KWO_RS20215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KWO_RS20220	COG1136	(ABC) transporter
KWO_RS20225	COG0577	efflux transmembrane transporter activity
KWO_RS20230	COG0577	efflux transmembrane transporter activity
KWO_RS20240	COG4191	Histidine kinase
KWO_RS20275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KWO_RS20280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KWO_RS20285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KWO_RS20290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KWO_RS20305	COG0356	it plays a direct role in the translocation of protons across the membrane
KWO_RS20325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KWO_RS20335	COG0508	dehydrogenase complex catalyzes the overall conversion of
KWO_RS20380	COG2011	ABC-type metal ion transport system permease component
KWO_RS20385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KWO_RS20390	COG0697	spore germination
KWO_RS20395	COG1666	GTP binding
KWO_RS20405	COG0784	Response regulator, receiver
KWO_RS20405	COG5002	protein histidine kinase activity
KWO_RS20405	COG2198	Histidine kinase
KWO_RS20425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KWO_RS20430	COG1187	pseudouridine synthase activity
KWO_RS20435	COG2813	Specifically methylates the guanine in position
KWO_RS20465	COG2205	protein histidine kinase activity
KWO_RS20465	COG2202	Pas domain
KWO_RS20485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KWO_RS20490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KWO_RS20535	COG0745	RESPONSE REGULATOR receiver
KWO_RS20550	COG1404	Belongs to the peptidase S8 family
KWO_RS20575	COG0842	Transport permease protein
KWO_RS20580	COG1131	(ABC) transporter
KWO_RS20585	COG0025	NhaP-type Na H and K H
KWO_RS20595	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KWO_RS20600	COG1573	uracil-dna glycosylase
KWO_RS20615	COG3384	dioxygenase
KWO_RS20625	COG0583	DNA-binding transcription factor activity
KWO_RS20635	COG0667	Aldo Keto reductase
KWO_RS20645	COG3590	peptidase
KWO_RS20660	COG0531	amino acid
KWO_RS20675	COG2972	Histidine kinase
KWO_RS20700	COG3685	Protein conserved in bacteria
KWO_RS20705	COG3546	catalase activity
KWO_RS20750	COG1271	oxidase subunit
KWO_RS20755	COG1294	oxidase, subunit
KWO_RS20770	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS20780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KWO_RS20800	COG1132	(ABC) transporter
KWO_RS20815	COG1063	alcohol dehydrogenase
KWO_RS20870	COG1131	(ABC) transporter
KWO_RS20900	COG0038	chloride channel
KWO_RS20910	COG0024	Methionine aminopeptidase
KWO_RS20940	COG3179	chitinase
KWO_RS21020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KWO_RS21025	COG1490	D-aminoacyl-tRNA deacylase activity
KWO_RS21030	COG1560	Kdo2-lipid A biosynthetic process
KWO_RS21075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KWO_RS21075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KWO_RS21080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KWO_RS21085	COG0242	peptide deformylase activity
KWO_RS21090	COG1652	LysM domain
KWO_RS21095	COG0758	DNA mediated transformation
KWO_RS21115	COG1754	DNA topoisomerase type I activity
KWO_RS21115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KWO_RS21120	COG0009	L-threonylcarbamoyladenylate synthase
KWO_RS21135	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_RS21145	COG0616	signal peptide processing
KWO_RS21150	COG0534	Mate efflux family protein
KWO_RS21175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KWO_RS21180	COG0625	glutathione transferase activity
KWO_RS21195	COG1252	NADH dehydrogenase
KWO_RS21200	COG2860	membrane
KWO_RS21205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KWO_RS21210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KWO_RS21215	COG3437	response regulator, receiver
KWO_RS21220	COG2177	Part of the ABC transporter FtsEX involved in
KWO_RS21225	COG2884	Cell division ATP-binding protein ftsE
KWO_RS21235	COG3118	belongs to the thioredoxin family
KWO_RS21240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KWO_RS21250	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
KWO_RS21300	COG1518	maintenance of DNA repeat elements
KWO_RS21305	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KWO_RS21315	COG1652	LysM domain
KWO_RS21320	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KWO_RS21320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KWO_RS21325	COG1473	amidohydrolase
KWO_RS21335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KWO_RS21360	COG5383	Protein conserved in bacteria
KWO_RS21400	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KWO_RS21405	COG3023	N-Acetylmuramoyl-L-alanine amidase
KWO_RS21415	COG4948	Mandelate Racemase Muconate Lactonizing
KWO_RS21425	COG0531	amino acid
KWO_RS21440	COG4682	membrane
KWO_RS21445	COG2133	pyrroloquinoline quinone binding
KWO_RS21455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KWO_RS21460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KWO_RS21470	COG1610	YqeY-like protein
KWO_RS21475	COG1295	ribonuclease BN
KWO_RS21480	COG0358	DNA primase activity
KWO_RS21495	COG0109	protoheme IX farnesyltransferase activity
KWO_RS21525	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KWO_RS21540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KWO_RS21610	COG0676	glucose-6-phosphate 1-epimerase activity
KWO_RS21620	COG3012	SEC-C Motif Domain Protein
KWO_RS21625	COG0730	response to heat
KWO_RS21655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KWO_RS21660	COG0302	gtp cyclohydrolase
KWO_RS21675	COG1566	PFAM secretion protein HlyD family protein
KWO_RS21685	COG1289	transmembrane transporter activity
KWO_RS21690	COG0477	Major facilitator Superfamily
KWO_RS21700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KWO_RS21750	COG0564	pseudouridine synthase activity
KWO_RS21770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KWO_RS21820	COG3549	Plasmid maintenance system killer
KWO_RS21825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KWO_RS21830	COG1074	ATP-dependent DNA helicase activity
KWO_RS21835	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KWO_RS21870	COG1127	ABC transporter
KWO_RS21875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KWO_RS21880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KWO_RS21895	COG2853	Lipoprotein
KWO_RS21905	COG0386	Belongs to the glutathione peroxidase family
KWO_RS21915	COG1322	Protein conserved in bacteria
KWO_RS21920	COG0604	alcohol dehydrogenase
KWO_RS21950	COG0531	amino acid
KWO_RS21975	COG2203	Gaf domain
KWO_RS21975	COG2199	diguanylate cyclase activity
KWO_RS21980	COG3835	regulator
KWO_RS21985	COG1929	Belongs to the glycerate kinase type-1 family
KWO_RS21990	COG2271	Major facilitator Superfamily
KWO_RS22010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KWO_RS22020	COG0861	Integral membrane protein TerC family
KWO_RS22030	COG0584	glycerophosphoryl diester phosphodiesterase
KWO_RS22045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KWO_RS22055	COG0706	membrane insertase activity
KWO_RS22090	COG3451	type IV secretory pathway VirB4
KWO_RS22105	COG3846	protein secretion by the type IV secretion system
KWO_RS22270	COG0489	protein tyrosine kinase activity
KWO_RS22335	COG4962	Type ii secretion system protein e
KWO_RS22350	COG3451	type IV secretory pathway VirB4
KWO_RS22365	COG3846	protein secretion by the type IV secretion system