locus-tag	class	description
BHE83_RS00010	COG0575	Belongs to the CDS family
BHE83_RS00015	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BHE83_RS00020	COG0233	cytoplasmic translational termination
BHE83_RS00025	COG0528	UMP kinase activity
BHE83_RS00035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BHE83_RS00040	COG0052	Belongs to the universal ribosomal protein uS2 family
BHE83_RS00080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BHE83_RS00090	COG1393	Belongs to the ArsC family
BHE83_RS00095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BHE83_RS00100	COG0367	asparagine synthase
BHE83_RS00125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BHE83_RS00150	COG1566	PFAM secretion protein HlyD family protein
BHE83_RS00155	COG2814	Major facilitator Superfamily
BHE83_RS00215	COG0339	signal peptide processing
BHE83_RS00220	COG0386	Belongs to the glutathione peroxidase family
BHE83_RS00280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BHE83_RS00285	COG0084	hydrolase, TatD family'
BHE83_RS00300	COG1960	acyl-CoA dehydrogenase activity
BHE83_RS00315	COG0367	asparagine synthase
BHE83_RS00325	COG0305	Participates in initiation and elongation during chromosome replication
BHE83_RS00330	COG0415	Belongs to the DNA photolyase family
BHE83_RS00340	COG0583	DNA-binding transcription factor activity
BHE83_RS00385	COG3706	GGDEF domain
BHE83_RS00400	COG2963	transposase activity
BHE83_RS00425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BHE83_RS00440	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BHE83_RS00450	COG0497	DNA recombination
BHE83_RS00455	COG1420	regulation of RNA biosynthetic process
BHE83_RS00460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BHE83_RS00465	COG0443	Heat shock 70 kDa protein
BHE83_RS00470	COG0484	heat shock protein binding
BHE83_RS00475	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BHE83_RS00505	COG0583	DNA-binding transcription factor activity
BHE83_RS00510	COG1132	(ABC) transporter
BHE83_RS00545	COG2850	peptidyl-arginine hydroxylation
BHE83_RS00565	COG1253	flavin adenine dinucleotide binding
BHE83_RS00595	COG1131	(ABC) transporter
BHE83_RS00600	COG1725	Transcriptional regulator
BHE83_RS00605	COG0386	Belongs to the glutathione peroxidase family
BHE83_RS00620	COG2900	Belongs to the SlyX family
BHE83_RS00645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BHE83_RS00655	COG0646	methionine synthase
BHE83_RS00655	COG1410	methionine synthase
BHE83_RS00660	COG1410	methionine synthase
BHE83_RS00660	COG0646	methionine synthase
BHE83_RS00665	COG2226	methyltransferase
BHE83_RS00670	COG1960	acyl-CoA dehydrogenase activity
BHE83_RS00690	COG0557	exoribonuclease II activity
BHE83_RS00705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BHE83_RS00720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BHE83_RS00730	COG0704	Plays a role in the regulation of phosphate uptake
BHE83_RS00735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BHE83_RS00740	COG0581	inorganic phosphate transmembrane transporter activity
BHE83_RS00745	COG0573	inorganic phosphate transmembrane transporter activity
BHE83_RS00750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BHE83_RS00775	COG0659	secondary active sulfate transmembrane transporter activity
BHE83_RS00780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BHE83_RS00790	COG1024	Enoyl-CoA hydratase
BHE83_RS00800	COG0494	nUDIX hydrolase
BHE83_RS00835	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BHE83_RS00845	COG0116	Belongs to the methyltransferase superfamily
BHE83_RS00845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BHE83_RS00850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BHE83_RS00870	COG2925	Exonuclease
BHE83_RS00880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BHE83_RS00885	COG3844	kynureninase activity
BHE83_RS00895	COG0662	Cupin 2, conserved barrel domain protein
BHE83_RS00900	COG0288	reversible hydration of carbon dioxide
BHE83_RS00955	COG2808	Putative FMN-binding domain
BHE83_RS00975	COG0017	Asparaginyl-tRNA synthetase
BHE83_RS00980	COG0316	Belongs to the HesB IscA family
BHE83_RS00985	COG0360	Binds together with S18 to 16S ribosomal RNA
BHE83_RS00990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BHE83_RS00995	COG0359	binds to the 23S rRNA
BHE83_RS01005	COG3115	cell septum assembly
BHE83_RS01015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BHE83_RS01020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BHE83_RS01025	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BHE83_RS01040	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BHE83_RS01050	COG4993	Dehydrogenase
BHE83_RS01060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BHE83_RS01070	COG2986	histidine ammonia-lyase
BHE83_RS01075	COG1228	amidohydrolase
BHE83_RS01115	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BHE83_RS01120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BHE83_RS01125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BHE83_RS01130	COG0077	Prephenate dehydratase
BHE83_RS01130	COG1605	Chorismate mutase
BHE83_RS01135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BHE83_RS01150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BHE83_RS01155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BHE83_RS01160	COG0583	DNA-binding transcription factor activity
BHE83_RS01180	COG2801	Transposase and inactivated derivatives
BHE83_RS01195	COG0840	transmembrane signaling receptor activity
BHE83_RS01230	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BHE83_RS01235	COG4191	Histidine kinase
BHE83_RS01235	COG0784	Response regulator, receiver
BHE83_RS01250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHE83_RS01260	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BHE83_RS01270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BHE83_RS01285	COG1595	DNA-templated transcription, initiation
BHE83_RS01325	COG2244	polysaccharide biosynthetic process
BHE83_RS01355	COG2264	protein methyltransferase activity
BHE83_RS01365	COG0438	transferase activity, transferring glycosyl groups
BHE83_RS01385	COG1136	(ABC) transporter
BHE83_RS01390	COG1132	(ABC) transporter
BHE83_RS01400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BHE83_RS01415	COG1253	flavin adenine dinucleotide binding
BHE83_RS01425	COG0306	phosphate transporter
BHE83_RS01450	COG0504	CTP synthase activity
BHE83_RS01455	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BHE83_RS01465	COG0148	phosphopyruvate hydratase activity
BHE83_RS01470	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BHE83_RS01475	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BHE83_RS01480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BHE83_RS01485	COG0585	pseudouridine synthase activity
BHE83_RS01490	COG2840	Smr protein MutS2
BHE83_RS01495	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BHE83_RS01500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BHE83_RS01505	COG1238	metal cluster binding
BHE83_RS01520	COG1534	Rna-binding protein
BHE83_RS01525	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BHE83_RS01535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BHE83_RS01540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BHE83_RS01550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BHE83_RS01555	COG1546	Belongs to the CinA family
BHE83_RS01565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BHE83_RS01570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BHE83_RS01575	COG2137	regulation of response to DNA damage stimulus
BHE83_RS01580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BHE83_RS01585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BHE83_RS01600	COG1741	Belongs to the pirin family
BHE83_RS01610	COG0583	DNA-binding transcription factor activity
BHE83_RS01635	COG0351	phosphomethylpyrimidine kinase
BHE83_RS01650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BHE83_RS01655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BHE83_RS01670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BHE83_RS01680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BHE83_RS01685	COG3734	2-keto-3-deoxy-galactonokinase
BHE83_RS01695	COG4948	Mandelate Racemase Muconate Lactonizing
BHE83_RS01700	COG0800	Aldolase
BHE83_RS01740	COG1501	Belongs to the glycosyl hydrolase 31 family
BHE83_RS01750	COG1070	Carbohydrate kinase
BHE83_RS01755	COG2115	Belongs to the xylose isomerase family
BHE83_RS01760	COG0477	Major facilitator Superfamily
BHE83_RS01775	COG0860	N-Acetylmuramoyl-L-alanine amidase
BHE83_RS01780	COG1469	GTP cyclohydrolase I activity
BHE83_RS01800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BHE83_RS01805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BHE83_RS01810	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BHE83_RS01815	COG0166	Belongs to the GPI family
BHE83_RS01835	COG1472	Belongs to the glycosyl hydrolase 3 family
BHE83_RS01845	COG5001	Diguanylate cyclase
BHE83_RS01845	COG2203	Gaf domain
BHE83_RS01845	COG3706	GGDEF domain
BHE83_RS01845	COG4251	negative regulation of phosphorylation
BHE83_RS01850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BHE83_RS01855	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BHE83_RS01865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BHE83_RS01870	COG0671	phosphoesterase, PA-phosphatase related
BHE83_RS01880	COG1794	racemase activity, acting on amino acids and derivatives
BHE83_RS01885	COG0697	spore germination
BHE83_RS01890	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BHE83_RS01895	COG0167	dihydroorotate dehydrogenase activity
BHE83_RS01910	COG1012	belongs to the aldehyde dehydrogenase family
BHE83_RS01925	COG2963	transposase activity
BHE83_RS01940	COG2801	Transposase and inactivated derivatives
BHE83_RS01950	COG2801	Transposase and inactivated derivatives
BHE83_RS01955	COG2963	transposase activity
BHE83_RS01970	COG2801	Transposase and inactivated derivatives
BHE83_RS01975	COG2801	Transposase and inactivated derivatives
BHE83_RS01980	COG2963	transposase activity
BHE83_RS02020	COG3210	domain, Protein
BHE83_RS02030	COG2963	transposase activity
BHE83_RS02040	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BHE83_RS02045	COG0527	aspartate kinase activity
BHE83_RS02045	COG0460	homoserine dehydrogenase
BHE83_RS02070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHE83_RS02075	COG0124	histidyl-tRNA synthetase
BHE83_RS02085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BHE83_RS02090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BHE83_RS02095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BHE83_RS02100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BHE83_RS02100	COG0131	Imidazoleglycerol-phosphate dehydratase
BHE83_RS02105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BHE83_RS02110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BHE83_RS02115	COG0107	imidazoleglycerol-phosphate synthase activity
BHE83_RS02120	COG0140	phosphoribosyl-ATP diphosphatase activity
BHE83_RS02120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BHE83_RS02135	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BHE83_RS02140	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BHE83_RS02145	COG0235	Class ii aldolase
BHE83_RS02150	COG0531	amino acid
BHE83_RS02155	COG0531	amino acid
BHE83_RS02165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BHE83_RS02170	COG0277	FAD linked oxidase domain protein
BHE83_RS02190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BHE83_RS02235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BHE83_RS02240	COG2258	MOSC domain
BHE83_RS02245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BHE83_RS02250	COG0505	Belongs to the CarA family
BHE83_RS02260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BHE83_RS02265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BHE83_RS02275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BHE83_RS02285	COG3279	Response regulator of the LytR AlgR family
BHE83_RS02290	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BHE83_RS02295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BHE83_RS02305	COG2198	Histidine kinase
BHE83_RS02305	COG2205	protein histidine kinase activity
BHE83_RS02305	COG0784	Response regulator, receiver
BHE83_RS02310	COG2205	protein histidine kinase activity
BHE83_RS02310	COG2198	Histidine kinase
BHE83_RS02310	COG0784	Response regulator, receiver
BHE83_RS02315	COG1024	Enoyl-CoA hydratase
BHE83_RS02320	COG0318	PFAM AMP-dependent synthetase and ligase
BHE83_RS02350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BHE83_RS02360	COG2201	protein-glutamate methylesterase activity
BHE83_RS02365	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BHE83_RS02375	COG0840	transmembrane signaling receptor activity
BHE83_RS02385	COG0835	chemotaxis
BHE83_RS02395	COG0840	transmembrane signaling receptor activity
BHE83_RS02400	COG0840	transmembrane signaling receptor activity
BHE83_RS02405	COG0840	transmembrane signaling receptor activity
BHE83_RS02410	COG0840	transmembrane signaling receptor activity
BHE83_RS02415	COG0840	transmembrane signaling receptor activity
BHE83_RS02425	COG0840	transmembrane signaling receptor activity
BHE83_RS02430	COG0840	transmembrane signaling receptor activity
BHE83_RS02435	COG0840	transmembrane signaling receptor activity
BHE83_RS02450	COG0840	transmembrane signaling receptor activity
BHE83_RS02465	COG0840	transmembrane signaling receptor activity
BHE83_RS02470	COG0840	transmembrane signaling receptor activity
BHE83_RS02480	COG0745	RESPONSE REGULATOR receiver
BHE83_RS02490	COG0835	chemotaxis
BHE83_RS02500	COG1360	Flagellar Motor Protein
BHE83_RS02505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BHE83_RS02535	COG2963	transposase activity
BHE83_RS02565	COG0784	Response regulator, receiver
BHE83_RS02565	COG2198	Histidine kinase
BHE83_RS02565	COG0643	Histidine kinase
BHE83_RS02620	COG1684	flagellar biosynthetic protein fliR
BHE83_RS02635	COG3190	flagellar
BHE83_RS02685	COG1677	Flagellar hook-basal body complex protein FliE
BHE83_RS02695	COG0275	rRNA processing
BHE83_RS02700	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BHE83_RS02735	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS02740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHE83_RS02760	COG2201	protein-glutamate methylesterase activity
BHE83_RS02790	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BHE83_RS02795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BHE83_RS02800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BHE83_RS02810	COG3951	Flagellar rod assembly protein muramidase FlgJ
BHE83_RS02810	COG1705	Flagellar rod assembly protein muramidase FlgJ
BHE83_RS02815	COG1706	bacterial-type flagellum-dependent cell motility
BHE83_RS02820	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BHE83_RS02835	COG4787	bacterial-type flagellum-dependent cell motility
BHE83_RS02845	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BHE83_RS02850	COG1558	bacterial-type flagellum-dependent cell motility
BHE83_RS02860	COG0784	Response regulator, receiver
BHE83_RS02860	COG0835	chemotaxis
BHE83_RS02880	COG5002	protein histidine kinase activity
BHE83_RS02910	COG2915	High frequency lysogenization protein hflD homolog
BHE83_RS02915	COG0482	sulfurtransferase activity
BHE83_RS02930	COG0542	response to heat
BHE83_RS02940	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BHE83_RS02955	COG0492	ferredoxin-NADP+ reductase activity
BHE83_RS02960	COG1674	ftsk spoiiie
BHE83_RS02970	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BHE83_RS02980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BHE83_RS02985	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BHE83_RS02990	COG0183	Belongs to the thiolase family
BHE83_RS02995	COG1250	3-hydroxyacyl-CoA dehydrogenase
BHE83_RS02995	COG1024	Enoyl-CoA hydratase
BHE83_RS03010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BHE83_RS03020	COG1426	Protein conserved in bacteria
BHE83_RS03030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BHE83_RS03035	COG1160	GTP binding
BHE83_RS03040	COG0303	'Molybdopterin
BHE83_RS03045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BHE83_RS03085	COG0708	Exodeoxyribonuclease III
BHE83_RS03095	COG0303	'Molybdopterin
BHE83_RS03100	COG0746	molybdenum cofactor guanylyltransferase activity
BHE83_RS03125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BHE83_RS03125	COG1648	precorrin-2 dehydrogenase activity
BHE83_RS03135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BHE83_RS03140	COG2223	nitrite transmembrane transporter activity
BHE83_RS03145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BHE83_RS03155	COG0243	molybdopterin cofactor binding
BHE83_RS03170	COG3685	Protein conserved in bacteria
BHE83_RS03190	COG5001	Diguanylate cyclase
BHE83_RS03200	COG4566	intracellular signal transduction
BHE83_RS03220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_RS03240	COG3279	Response regulator of the LytR AlgR family
BHE83_RS03380	COG0631	protein serine/threonine phosphatase activity
BHE83_RS03385	COG0515	serine threonine protein kinase
BHE83_RS03415	COG1858	cytochrome C peroxidase
BHE83_RS03430	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BHE83_RS03445	COG4585	Histidine kinase
BHE83_RS03450	COG2197	response regulator
BHE83_RS03470	COG2801	Transposase and inactivated derivatives
BHE83_RS03510	COG1002	Type II restriction enzyme, methylase subunits
BHE83_RS03515	COG1061	Type III restriction enzyme res subunit
BHE83_RS03520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BHE83_RS03525	COG1196	nuclear chromosome segregation
BHE83_RS03545	COG2818	Glycosylase
BHE83_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS03560	COG0583	DNA-binding transcription factor activity
BHE83_RS03570	COG3002	Belongs to the UPF0753 family
BHE83_RS03575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BHE83_RS03580	COG0583	DNA-binding transcription factor activity
BHE83_RS03590	COG0633	Ferredoxin
BHE83_RS03610	COG0583	DNA-binding transcription factor activity
BHE83_RS03630	COG2197	response regulator
BHE83_RS03635	COG4585	Histidine kinase
BHE83_RS03645	COG1335	isochorismatase
BHE83_RS03660	COG2814	Major facilitator Superfamily
BHE83_RS03680	COG1914	H( )-stimulated, divalent metal cation uptake system
BHE83_RS03695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BHE83_RS03700	COG0668	transmembrane transport
BHE83_RS03710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BHE83_RS03725	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS03730	COG1183	phosphatidylcholine synthase activity
BHE83_RS03740	COG3243	poly(R)-hydroxyalkanoic acid synthase
BHE83_RS03755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHE83_RS03755	COG0723	plastoquinol--plastocyanin reductase activity
BHE83_RS03765	COG2183	response to ionizing radiation
BHE83_RS03770	COG2205	protein histidine kinase activity
BHE83_RS03770	COG0784	Response regulator, receiver
BHE83_RS03785	COG0582	viral genome integration into host DNA
BHE83_RS03860	COG0800	Aldolase
BHE83_RS03865	COG0129	dihydroxy-acid dehydratase activity
BHE83_RS03870	COG0363	glucosamine-6-phosphate deaminase activity
BHE83_RS03875	COG0837	glucose binding
BHE83_RS03880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BHE83_RS03890	COG0354	folic acid binding
BHE83_RS03900	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BHE83_RS03915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BHE83_RS03920	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BHE83_RS03930	COG4591	ABC-type transport system involved in lipoprotein release permease component
BHE83_RS03935	COG1136	(ABC) transporter
BHE83_RS03950	COG0811	peptide transport
BHE83_RS03960	COG1132	(ABC) transporter
BHE83_RS03965	COG1663	tetraacyldisaccharide 4'-kinase activity
BHE83_RS03970	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BHE83_RS03975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BHE83_RS03985	COG0322	excinuclease ABC activity
BHE83_RS03990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BHE83_RS04000	COG0582	viral genome integration into host DNA
BHE83_RS04005	COG2801	Transposase and inactivated derivatives
BHE83_RS04050	COG2826	transposase and inactivated derivatives, IS30 family
BHE83_RS04060	COG4644	lycopene metabolic process
BHE83_RS04115	COG0270	DNA (cytosine-5-)-methyltransferase activity
BHE83_RS04125	COG0629	single-stranded DNA binding
BHE83_RS04165	COG2801	Transposase and inactivated derivatives
BHE83_RS04185	COG0582	viral genome integration into host DNA
BHE83_RS04195	COG1396	sequence-specific DNA binding
BHE83_RS04200	COG0583	DNA-binding transcription factor activity
BHE83_RS04230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHE83_RS04235	COG4232	protein-disulfide reductase activity
BHE83_RS04240	COG0745	RESPONSE REGULATOR receiver
BHE83_RS04250	COG0492	ferredoxin-NADP+ reductase activity
BHE83_RS04275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BHE83_RS04285	COG1275	C4-dicarboxylate transporter malic acid transport protein
BHE83_RS04315	COG1573	uracil-dna glycosylase
BHE83_RS04330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BHE83_RS04355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BHE83_RS04365	COG2814	Major facilitator Superfamily
BHE83_RS04370	COG0789	Transcriptional regulator
BHE83_RS04380	COG0640	Transcriptional regulator
BHE83_RS04385	COG1230	cation diffusion facilitator family transporter
BHE83_RS04450	COG2801	Transposase and inactivated derivatives
BHE83_RS04460	COG0583	DNA-binding transcription factor activity
BHE83_RS04515	COG2003	Belongs to the UPF0758 family
BHE83_RS04715	COG0270	DNA (cytosine-5-)-methyltransferase activity
BHE83_RS04720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BHE83_RS04725	COG0629	single-stranded DNA binding
BHE83_RS04780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BHE83_RS04800	COG1054	Belongs to the UPF0176 family
BHE83_RS04810	COG1530	ribonuclease E activity
BHE83_RS04820	COG3064	Membrane
BHE83_RS04825	COG0428	transporter
BHE83_RS04835	COG2154	pterin-4-alpha-carbinolamine dehydratase
BHE83_RS04840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BHE83_RS04840	COG0316	Belongs to the HesB IscA family
BHE83_RS04855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_RS04860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BHE83_RS04890	COG4644	lycopene metabolic process
BHE83_RS04895	COG2951	lytic endotransglycosylase activity
BHE83_RS04900	COG0730	response to heat
BHE83_RS04925	COG0640	Transcriptional regulator
BHE83_RS05045	COG1484	DNA-dependent DNA replication
BHE83_RS05055	COG2801	Transposase and inactivated derivatives
BHE83_RS05085	COG0582	viral genome integration into host DNA
BHE83_RS05090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BHE83_RS05090	COG0519	Catalyzes the synthesis of GMP from XMP
BHE83_RS05100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BHE83_RS05110	COG0475	glutathione-regulated potassium exporter activity
BHE83_RS05110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BHE83_RS05115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BHE83_RS05125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BHE83_RS05130	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BHE83_RS05140	COG0776	regulation of translation
BHE83_RS05145	COG0539	negative regulation of cytoplasmic translation
BHE83_RS05150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BHE83_RS05165	COG2957	Belongs to the agmatine deiminase family
BHE83_RS05170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BHE83_RS05195	COG0395	ABC-type sugar transport system, permease component
BHE83_RS05200	COG1175	transmembrane transport
BHE83_RS05230	COG2350	Protein conserved in bacteria
BHE83_RS05235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BHE83_RS05240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BHE83_RS05245	COG1187	pseudouridine synthase activity
BHE83_RS05265	COG0436	Aminotransferase
BHE83_RS05270	COG4133	protoheme IX ABC transporter activity
BHE83_RS05290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BHE83_RS05295	COG1138	Cytochrome C-type biogenesis protein
BHE83_RS05315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BHE83_RS05320	COG1278	Cold shock
BHE83_RS05325	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BHE83_RS05330	COG4988	ABC transporter
BHE83_RS05340	COG1294	oxidase, subunit
BHE83_RS05370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BHE83_RS05375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BHE83_RS05385	COG0165	Argininosuccinate lyase
BHE83_RS05390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BHE83_RS05400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BHE83_RS05405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BHE83_RS05415	COG0137	argininosuccinate synthase activity
BHE83_RS05420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BHE83_RS05430	COG0215	cysteine-tRNA ligase activity
BHE83_RS05435	COG2166	iron-sulfur cluster assembly
BHE83_RS05450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BHE83_RS05455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BHE83_RS05475	COG4303	Ethanolamine ammonia lyase large subunit
BHE83_RS05525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BHE83_RS05530	COG0402	S-adenosylhomocysteine deaminase activity
BHE83_RS05540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BHE83_RS05545	COG1509	lysine 2,3-aminomutase activity
BHE83_RS05550	COG5001	Diguanylate cyclase
BHE83_RS05550	COG3300	MHYT domain
BHE83_RS05565	COG0483	inositol monophosphate 1-phosphatase activity
BHE83_RS05570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BHE83_RS05585	COG0488	(ABC) transporter
BHE83_RS05590	COG0513	Belongs to the DEAD box helicase family
BHE83_RS05595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BHE83_RS05600	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BHE83_RS05610	COG0625	glutathione transferase activity
BHE83_RS05620	COG4681	YaeQ
BHE83_RS05625	COG2081	HI0933 family
BHE83_RS05635	COG0501	Belongs to the peptidase M48B family
BHE83_RS05640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BHE83_RS05645	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS05670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BHE83_RS05675	COG0860	N-Acetylmuramoyl-L-alanine amidase
BHE83_RS05680	COG0802	atpase or kinase
BHE83_RS05685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BHE83_RS05685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BHE83_RS05690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BHE83_RS05695	COG1570	exodeoxyribonuclease VII activity
BHE83_RS05705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BHE83_RS05740	COG0582	viral genome integration into host DNA
BHE83_RS05750	COG2963	transposase activity
BHE83_RS05785	COG0835	chemotaxis
BHE83_RS05790	COG0840	transmembrane signaling receptor activity
BHE83_RS05795	COG2094	Belongs to the DNA glycosylase MPG family
BHE83_RS05800	COG1201	RNA secondary structure unwinding
BHE83_RS05820	COG2969	positive regulation of protein catabolic process
BHE83_RS05825	COG0625	glutathione transferase activity
BHE83_RS05830	COG2857	Cytochrome c1
BHE83_RS05835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BHE83_RS05840	COG0723	plastoquinol--plastocyanin reductase activity
BHE83_RS05845	COG0741	lytic transglycosylase activity
BHE83_RS05860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BHE83_RS05865	COG1702	phosphate starvation-inducible protein PhoH
BHE83_RS05875	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BHE83_RS05885	COG4535	Mg2 and Co2 transporter CorC
BHE83_RS05900	COG1012	belongs to the aldehyde dehydrogenase family
BHE83_RS05910	COG1177	transmembrane transport
BHE83_RS05915	COG1176	ABC-type spermidine putrescine transport system, permease component I
BHE83_RS05945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BHE83_RS05960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BHE83_RS05965	COG0174	glutamine synthetase
BHE83_RS05970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHE83_RS05980	COG2703	oxygen carrier activity
BHE83_RS05985	COG0477	Major facilitator Superfamily
BHE83_RS05995	COG0243	molybdopterin cofactor binding
BHE83_RS06000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BHE83_RS06005	COG2223	nitrite transmembrane transporter activity
BHE83_RS06010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BHE83_RS06020	COG2733	membrane
BHE83_RS06025	COG5002	protein histidine kinase activity
BHE83_RS06025	COG0784	Response regulator, receiver
BHE83_RS06025	COG2205	protein histidine kinase activity
BHE83_RS06035	COG0477	Major facilitator Superfamily
BHE83_RS06040	COG2902	Dehydrogenase
BHE83_RS06050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_RS06055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BHE83_RS06060	COG1609	Transcriptional regulator
BHE83_RS06065	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BHE83_RS06065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BHE83_RS06070	COG1105	Belongs to the carbohydrate kinase PfkB family
BHE83_RS06075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BHE83_RS06075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BHE83_RS06115	COG2801	Transposase and inactivated derivatives
BHE83_RS06125	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BHE83_RS06135	COG1862	Preprotein translocase
BHE83_RS06140	COG0343	queuine tRNA-ribosyltransferase activity
BHE83_RS06145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BHE83_RS06185	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BHE83_RS06190	COG3291	Pkd domain containing protein
BHE83_RS06200	COG0405	Gamma-glutamyltransferase
BHE83_RS06205	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BHE83_RS06220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BHE83_RS06225	COG0742	ribosomal rna small subunit methyltransferase
BHE83_RS06230	COG0326	Molecular chaperone. Has ATPase activity
BHE83_RS06265	COG2963	transposase activity
BHE83_RS06340	COG0531	amino acid
BHE83_RS06355	COG0006	proline dipeptidase activity
BHE83_RS06365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BHE83_RS06380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHE83_RS06385	COG3938	Belongs to the proline racemase family
BHE83_RS06395	COG0552	protein localization to endoplasmic reticulum
BHE83_RS06400	COG1194	a g-specific adenine glycosylase
BHE83_RS06405	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BHE83_RS06410	COG0784	Response regulator, receiver
BHE83_RS06410	COG4191	Histidine kinase
BHE83_RS06440	COG3040	lipid binding
BHE83_RS06450	COG1960	acyl-CoA dehydrogenase activity
BHE83_RS06460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BHE83_RS06480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BHE83_RS06485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHE83_RS06490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHE83_RS06505	COG2963	transposase activity
BHE83_RS06530	COG0438	transferase activity, transferring glycosyl groups
BHE83_RS06540	COG0438	transferase activity, transferring glycosyl groups
BHE83_RS06545	COG0438	transferase activity, transferring glycosyl groups
BHE83_RS06595	COG0072	phenylalanine-tRNA ligase activity
BHE83_RS06595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BHE83_RS06600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BHE83_RS06615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BHE83_RS06620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BHE83_RS06645	COG1082	Xylose isomerase domain protein TIM barrel
BHE83_RS06660	COG0366	Alpha amylase catalytic
BHE83_RS06670	COG2963	transposase activity
BHE83_RS06690	COG3505	Type IV secretory pathway VirD4
BHE83_RS06710	COG0556	nucleotide-excision repair
BHE83_RS06740	COG2963	transposase activity
BHE83_RS06755	COG1611	Belongs to the LOG family
BHE83_RS06765	COG2095	MarC family integral membrane protein
BHE83_RS06775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BHE83_RS06810	COG1185	polyribonucleotide nucleotidyltransferase activity
BHE83_RS06815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BHE83_RS06820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BHE83_RS06825	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BHE83_RS06830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BHE83_RS06835	COG0195	Participates in both transcription termination and antitermination
BHE83_RS06840	COG0779	Required for maturation of 30S ribosomal subunits
BHE83_RS06850	COG1007	ATP synthesis coupled electron transport
BHE83_RS06875	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BHE83_RS06880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BHE83_RS06885	COG1034	ATP synthesis coupled electron transport
BHE83_RS06890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BHE83_RS06895	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BHE83_RS06900	COG0649	NAD binding
BHE83_RS06905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BHE83_RS06910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BHE83_RS06915	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BHE83_RS06930	COG0149	triose-phosphate isomerase activity
BHE83_RS06935	COG4221	oxidoreductase activity
BHE83_RS06975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BHE83_RS06980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BHE83_RS06985	COG0159	tryptophan synthase activity
BHE83_RS06995	COG2801	Transposase and inactivated derivatives
BHE83_RS07010	COG0133	tryptophan synthase activity
BHE83_RS07020	COG0135	phosphoribosylanthranilate isomerase activity
BHE83_RS07025	COG0101	tRNA pseudouridine synthase activity
BHE83_RS07045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BHE83_RS07050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BHE83_RS07055	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BHE83_RS07060	COG2890	protein-(glutamine-N5) methyltransferase activity
BHE83_RS07070	COG0688	phosphatidylethanolamine metabolic process
BHE83_RS07080	COG0433	COG0433 Predicted ATPase
BHE83_RS07085	COG0494	nUDIX hydrolase
BHE83_RS07100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BHE83_RS07105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BHE83_RS07130	COG0717	Belongs to the dCTP deaminase family
BHE83_RS07135	COG0489	protein tyrosine kinase activity
BHE83_RS07155	COG3590	peptidase
BHE83_RS07160	COG3590	peptidase
BHE83_RS07180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHE83_RS07185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHE83_RS07190	COG2311	Membrane
BHE83_RS07195	COG1047	Peptidyl-prolyl cis-trans
BHE83_RS07200	COG0791	NLP P60 protein
BHE83_RS07205	COG0791	NLP P60 protein
BHE83_RS07220	COG1301	dicarboxylic acid transport
BHE83_RS07225	COG1785	Belongs to the alkaline phosphatase family
BHE83_RS07230	COG0037	tRNA processing
BHE83_RS07235	COG1722	exodeoxyribonuclease VII activity
BHE83_RS07240	COG0142	geranyltranstransferase activity
BHE83_RS07245	COG4104	PAAR repeat-containing protein
BHE83_RS07255	COG0312	modulator of DNA gyrase
BHE83_RS07260	COG3028	Belongs to the UPF0307 family
BHE83_RS07265	COG0312	modulator of DNA gyrase
BHE83_RS07275	COG3164	Protein of unknown function
BHE83_RS07285	COG0424	maF-like protein
BHE83_RS07290	COG2968	Membrane
BHE83_RS07300	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BHE83_RS07315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BHE83_RS07330	COG0495	leucyl-tRNA aminoacylation
BHE83_RS07340	COG3118	belongs to the thioredoxin family
BHE83_RS07370	COG2155	Conserved Protein
BHE83_RS07425	COG1132	(ABC) transporter
BHE83_RS07450	COG1538	Outer membrane efflux protein
BHE83_RS07455	COG0745	RESPONSE REGULATOR receiver
BHE83_RS07465	COG0475	glutathione-regulated potassium exporter activity
BHE83_RS07475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BHE83_RS07500	COG1187	pseudouridine synthase activity
BHE83_RS07505	COG5001	Diguanylate cyclase
BHE83_RS07505	COG5002	protein histidine kinase activity
BHE83_RS07610	COG0667	Aldo Keto reductase
BHE83_RS07615	COG2814	Major facilitator Superfamily
BHE83_RS07620	COG0583	DNA-binding transcription factor activity
BHE83_RS07630	COG2207	Transcriptional regulator
BHE83_RS07645	COG1309	transcriptional regulator
BHE83_RS07670	COG0735	belongs to the Fur family
BHE83_RS07675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BHE83_RS07700	COG4452	Inner membrane protein CreD
BHE83_RS07715	COG2205	protein histidine kinase activity
BHE83_RS07720	COG0745	RESPONSE REGULATOR receiver
BHE83_RS07725	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BHE83_RS07735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BHE83_RS07745	COG0643	Histidine kinase
BHE83_RS07745	COG2198	Histidine kinase
BHE83_RS07750	COG0840	transmembrane signaling receptor activity
BHE83_RS07755	COG0835	chemotaxis
BHE83_RS07760	COG2199	diguanylate cyclase activity
BHE83_RS07760	COG2202	Pas domain
BHE83_RS07760	COG2200	EAL domain
BHE83_RS07765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BHE83_RS07770	COG2201	protein-glutamate methylesterase activity
BHE83_RS07775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHE83_RS07780	COG3590	peptidase
BHE83_RS07790	COG0588	phosphoglycerate mutase activity
BHE83_RS07795	COG1515	deoxyribonuclease V activity
BHE83_RS07805	COG1741	Belongs to the pirin family
BHE83_RS07820	COG1741	Belongs to the pirin family
BHE83_RS07825	COG1966	Carbon starvation protein
BHE83_RS07830	COG2879	small protein
BHE83_RS07875	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BHE83_RS07880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BHE83_RS07885	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BHE83_RS07890	COG2080	2 iron, 2 sulfur cluster binding
BHE83_RS07895	COG3321	synthase
BHE83_RS07895	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS07895	COG0604	alcohol dehydrogenase
BHE83_RS07900	COG3706	GGDEF domain
BHE83_RS07900	COG2203	Gaf domain
BHE83_RS07900	COG4251	negative regulation of phosphorylation
BHE83_RS07900	COG5001	Diguanylate cyclase
BHE83_RS07905	COG0629	single-stranded DNA binding
BHE83_RS07910	COG0142	geranyltranstransferase activity
BHE83_RS07925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BHE83_RS07940	COG0527	aspartate kinase activity
BHE83_RS07945	COG0384	phenazine biosynthesis protein PhzF
BHE83_RS07950	COG0384	phenazine biosynthesis protein PhzF
BHE83_RS07960	COG1764	response to oxidative stress
BHE83_RS07965	COG0540	Belongs to the ATCase OTCase family
BHE83_RS07970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BHE83_RS07975	COG1678	Uncharacterized ACR, COG1678
BHE83_RS07985	COG0519	Catalyzes the synthesis of GMP from XMP
BHE83_RS08010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BHE83_RS08025	COG0739	heme binding
BHE83_RS08045	COG0693	protein deglycase activity
BHE83_RS08055	COG1959	2 iron, 2 sulfur cluster binding
BHE83_RS08060	COG0719	Fe-S assembly protein
BHE83_RS08065	COG0396	ATPase activity
BHE83_RS08070	COG0719	Fe-S assembly protein
BHE83_RS08075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BHE83_RS08085	COG2146	nitrite reductase [NAD(P)H] activity
BHE83_RS08090	COG4774	siderophore transport
BHE83_RS08095	COG3128	pkhd-type hydroxylase
BHE83_RS08120	COG1477	protein flavinylation
BHE83_RS08125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BHE83_RS08140	COG1555	photosystem II stabilization
BHE83_RS08160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BHE83_RS08170	COG0628	permease
BHE83_RS08180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BHE83_RS08190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BHE83_RS08210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BHE83_RS08215	COG0271	Belongs to the BolA IbaG family
BHE83_RS08225	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BHE83_RS08235	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BHE83_RS08240	COG1137	ATPase activity
BHE83_RS08255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BHE83_RS08260	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BHE83_RS08265	COG1660	Displays ATPase and GTPase activities
BHE83_RS08275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BHE83_RS08280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BHE83_RS08285	COG2239	Acts as a magnesium transporter
BHE83_RS08295	COG1294	oxidase, subunit
BHE83_RS08300	COG1271	oxidase subunit
BHE83_RS08310	COG1113	amino acid transport
BHE83_RS08330	COG2197	response regulator
BHE83_RS08335	COG0531	amino acid
BHE83_RS08405	COG2814	Major facilitator Superfamily
BHE83_RS08410	COG0754	glutathionylspermidine amidase activity
BHE83_RS08435	COG1842	Phage shock protein A
BHE83_RS08445	COG0259	pyridoxamine-phosphate oxidase activity
BHE83_RS08450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BHE83_RS08455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BHE83_RS08465	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BHE83_RS08470	COG2814	Major facilitator Superfamily
BHE83_RS08495	COG2205	protein histidine kinase activity
BHE83_RS08495	COG2198	Histidine kinase
BHE83_RS08495	COG0784	Response regulator, receiver
BHE83_RS08500	COG2353	YceI-like domain
BHE83_RS08520	COG1760	l-serine dehydratase
BHE83_RS08530	COG0460	homoserine dehydrogenase
BHE83_RS08530	COG0527	aspartate kinase activity
BHE83_RS08535	COG0626	cystathionine gamma-synthase activity
BHE83_RS08540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BHE83_RS08545	COG0739	heme binding
BHE83_RS08550	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BHE83_RS08555	COG1272	protein, Hemolysin III
BHE83_RS08560	COG2982	Protein involved in outer membrane biogenesis
BHE83_RS08565	COG0517	IMP dehydrogenase activity
BHE83_RS08565	COG0516	GMP reductase activity
BHE83_RS08570	COG0463	Glycosyl transferase, family 2
BHE83_RS08575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BHE83_RS08580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BHE83_RS08595	COG1309	transcriptional regulator
BHE83_RS08605	COG1960	acyl-CoA dehydrogenase activity
BHE83_RS08630	COG0509	glycine decarboxylation via glycine cleavage system
BHE83_RS08635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BHE83_RS08645	COG1742	UPF0060 membrane protein
BHE83_RS08650	COG3956	TIGRFAM MazG family protein
BHE83_RS08660	COG0494	nUDIX hydrolase
BHE83_RS08670	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BHE83_RS08675	COG0837	glucose binding
BHE83_RS08690	COG1388	LysM domain
BHE83_RS08690	COG3858	chitin binding
BHE83_RS08695	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BHE83_RS08705	COG1472	Belongs to the glycosyl hydrolase 3 family
BHE83_RS08715	COG3537	Alpha-1,2-mannosidase
BHE83_RS08750	COG3142	Participates in the control of copper homeostasis
BHE83_RS08755	COG1446	asparaginase
BHE83_RS08760	COG2304	oxidoreductase activity
BHE83_RS08765	COG1595	DNA-templated transcription, initiation
BHE83_RS08795	COG2198	Histidine kinase
BHE83_RS08795	COG0784	Response regulator, receiver
BHE83_RS08795	COG0643	Histidine kinase
BHE83_RS08800	COG0840	transmembrane signaling receptor activity
BHE83_RS08805	COG0835	chemotaxis
BHE83_RS08820	COG0189	ligase activity
BHE83_RS08830	COG1397	ADP-ribosylglycohydrolase
BHE83_RS08840	COG1397	ADP-ribosylglycohydrolase
BHE83_RS08850	COG1199	ATP-dependent helicase activity
BHE83_RS08860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BHE83_RS08865	COG1215	transferase activity, transferring glycosyl groups
BHE83_RS08875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BHE83_RS08880	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BHE83_RS08885	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BHE83_RS08890	COG0535	radical SAM domain protein
BHE83_RS08895	COG0535	radical SAM domain protein
BHE83_RS08915	COG0837	glucose binding
BHE83_RS08925	COG1643	Atp-dependent helicase
BHE83_RS08930	COG0783	Belongs to the Dps family
BHE83_RS08935	COG0514	ATP-dependent DNA helicase (RecQ)
BHE83_RS08965	COG1187	pseudouridine synthase activity
BHE83_RS08975	COG0840	transmembrane signaling receptor activity
BHE83_RS08995	COG3920	Histidine kinase
BHE83_RS09000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BHE83_RS09010	COG0602	queuosine metabolic process
BHE83_RS09020	COG2885	chlorophyll binding
BHE83_RS09025	COG0823	Involved in the tonB-independent uptake of proteins
BHE83_RS09035	COG0848	biopolymer transport protein
BHE83_RS09045	COG0824	Thioesterase
BHE83_RS09050	COG2255	four-way junction helicase activity
BHE83_RS09060	COG3158	transport of potassium into the cell
BHE83_RS09065	COG0632	four-way junction helicase activity
BHE83_RS09070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BHE83_RS09075	COG0217	transcriptional regulatory protein
BHE83_RS09090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BHE83_RS09105	COG0477	Major facilitator Superfamily
BHE83_RS09120	COG2755	lipolytic protein G-D-S-L family
BHE83_RS09120	COG0657	acetylesterase activity
BHE83_RS09140	COG0488	(ABC) transporter
BHE83_RS09180	COG4772	TonB-dependent receptor
BHE83_RS09190	COG4264	IucA IucC family
BHE83_RS09195	COG2814	Major facilitator Superfamily
BHE83_RS09205	COG0019	diaminopimelate decarboxylase activity
BHE83_RS09225	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BHE83_RS09235	COG1492	cobalamin metabolic process
BHE83_RS09245	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BHE83_RS09265	COG4206	TonB-dependent receptor
BHE83_RS09270	COG0542	response to heat
BHE83_RS09310	COG4771	TonB-dependent receptor
BHE83_RS09315	COG1877	trehalose-phosphatase activity
BHE83_RS09320	COG3387	PFAM Glycoside hydrolase 15-related
BHE83_RS09335	COG0840	transmembrane signaling receptor activity
BHE83_RS09340	COG3011	Protein conserved in bacteria
BHE83_RS09355	COG0564	pseudouridine synthase activity
BHE83_RS09360	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BHE83_RS09370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BHE83_RS09370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BHE83_RS09385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BHE83_RS09390	COG0045	succinate-CoA ligase (ADP-forming) activity
BHE83_RS09415	COG4969	Belongs to the N-Me-Phe pilin family
BHE83_RS09425	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BHE83_RS09430	COG0237	dephospho-CoA kinase activity
BHE83_RS09440	COG2963	transposase activity
BHE83_RS09450	COG2963	transposase activity
BHE83_RS09455	COG2801	Transposase and inactivated derivatives
BHE83_RS09465	COG0745	RESPONSE REGULATOR receiver
BHE83_RS09475	COG0189	ligase activity
BHE83_RS09535	COG2801	Transposase and inactivated derivatives
BHE83_RS09545	COG2963	transposase activity
BHE83_RS09580	COG3039	Transposase
BHE83_RS09595	COG2801	Transposase and inactivated derivatives
BHE83_RS09610	COG3220	belongs to the UPF0276 family
BHE83_RS09625	COG2003	Belongs to the UPF0758 family
BHE83_RS09645	COG2801	Transposase and inactivated derivatives
BHE83_RS09685	COG2022	thiamine diphosphate biosynthetic process
BHE83_RS09690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BHE83_RS09695	COG3273	potassium ion transport
BHE83_RS09695	COG0471	metal ion transport
BHE83_RS09715	COG1970	mechanosensitive ion channel activity
BHE83_RS09730	COG1609	Transcriptional regulator
BHE83_RS09740	COG3250	beta-galactosidase activity
BHE83_RS09745	COG4948	Mandelate Racemase Muconate Lactonizing
BHE83_RS09760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BHE83_RS09775	COG0308	aminopeptidase N
BHE83_RS09805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BHE83_RS09820	COG0529	Catalyzes the synthesis of activated sulfate
BHE83_RS09820	COG2895	sulfate adenylyltransferase (ATP) activity
BHE83_RS09825	COG0175	sulfate reduction
BHE83_RS09830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BHE83_RS09835	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BHE83_RS09840	COG0175	sulfate reduction
BHE83_RS09860	COG2198	Histidine kinase
BHE83_RS09860	COG0784	Response regulator, receiver
BHE83_RS09860	COG2205	protein histidine kinase activity
BHE83_RS09880	COG1648	precorrin-2 dehydrogenase activity
BHE83_RS09880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BHE83_RS09895	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BHE83_RS09900	COG3588	fructose-bisphosphate aldolase
BHE83_RS09905	COG0469	pyruvate kinase activity
BHE83_RS09915	COG0126	phosphoglycerate kinase activity
BHE83_RS09935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BHE83_RS09945	COG3047	cAMP biosynthetic process
BHE83_RS09950	COG3047	cAMP biosynthetic process
BHE83_RS09960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHE83_RS09960	COG3453	Protein conserved in bacteria
BHE83_RS09965	COG0725	ABC transporter, periplasmic molybdate-binding protein
BHE83_RS09970	COG4149	molybdate abc transporter
BHE83_RS09975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BHE83_RS10010	COG1376	ErfK ybiS ycfS ynhG family protein
BHE83_RS10015	COG0739	heme binding
BHE83_RS10020	COG4773	Receptor
BHE83_RS10025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BHE83_RS10030	COG1301	dicarboxylic acid transport
BHE83_RS10040	COG2304	oxidoreductase activity
BHE83_RS10060	COG0714	Associated with various cellular activities
BHE83_RS10090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BHE83_RS10110	COG1957	nucleoside hydrolase
BHE83_RS10115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BHE83_RS10125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BHE83_RS10135	COG0194	GDP metabolic process
BHE83_RS10140	COG1561	YicC-like family, N-terminal region
BHE83_RS10145	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BHE83_RS10155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BHE83_RS10160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BHE83_RS10175	COG0006	proline dipeptidase activity
BHE83_RS10185	COG0006	proline dipeptidase activity
BHE83_RS10190	COG3079	Belongs to the UPF0149 family
BHE83_RS10210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BHE83_RS10220	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BHE83_RS10230	COG2912	Transglutaminase-like superfamily
BHE83_RS10235	COG1773	rubredoxin
BHE83_RS10240	COG0352	thiamine-phosphate diphosphorylase activity
BHE83_RS10250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BHE83_RS10265	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BHE83_RS10270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BHE83_RS10300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BHE83_RS10305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHE83_RS10310	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS10320	COG0671	phosphoesterase, PA-phosphatase related
BHE83_RS10325	COG3781	membrane
BHE83_RS10335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BHE83_RS10340	COG0563	adenylate kinase activity
BHE83_RS10405	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BHE83_RS10415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BHE83_RS10435	COG3710	Transcriptional regulator
BHE83_RS10440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BHE83_RS10450	COG0840	transmembrane signaling receptor activity
BHE83_RS10455	COG0405	Gamma-glutamyltransferase
BHE83_RS10460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BHE83_RS10480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BHE83_RS10485	COG0473	3-isopropylmalate dehydrogenase activity
BHE83_RS10490	COG0066	3-isopropylmalate dehydratase activity
BHE83_RS10495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BHE83_RS10515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BHE83_RS10520	COG1538	Outer membrane efflux protein
BHE83_RS10525	COG1519	Transferase
BHE83_RS10530	COG1560	Kdo2-lipid A biosynthetic process
BHE83_RS10555	COG0281	malic enzyme
BHE83_RS10555	COG0280	phosphate acetyltransferase
BHE83_RS10560	COG1301	dicarboxylic acid transport
BHE83_RS10590	COG0583	DNA-binding transcription factor activity
BHE83_RS10600	COG0667	Aldo Keto reductase
BHE83_RS10615	COG2197	response regulator
BHE83_RS10625	COG0642	Histidine kinase
BHE83_RS10640	COG2851	Citrate transporter
BHE83_RS10645	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS10650	COG1609	Transcriptional regulator
BHE83_RS10655	COG2211	Major facilitator Superfamily
BHE83_RS10680	COG1162	GTPase activity
BHE83_RS10700	COG0726	polysaccharide deacetylase
BHE83_RS10705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BHE83_RS10720	COG3964	amidohydrolase
BHE83_RS10725	COG0402	S-adenosylhomocysteine deaminase activity
BHE83_RS10745	COG1307	EDD domain protein, DegV family
BHE83_RS10750	COG0242	peptide deformylase activity
BHE83_RS10770	COG0457	Tetratricopeptide repeat
BHE83_RS10775	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BHE83_RS10780	COG1215	transferase activity, transferring glycosyl groups
BHE83_RS10800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BHE83_RS10855	COG1450	Type ii and iii secretion system protein
BHE83_RS10870	COG3166	PFAM Fimbrial assembly family protein
BHE83_RS10875	COG3156	type II secretion system protein K
BHE83_RS10880	COG4795	General secretion pathway protein
BHE83_RS10885	COG2165	general secretion pathway protein
BHE83_RS10890	COG4970	Tfp pilus assembly protein FimT
BHE83_RS10895	COG2165	general secretion pathway protein
BHE83_RS10900	COG1459	type II secretion system
BHE83_RS10905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BHE83_RS10910	COG1404	Belongs to the peptidase S8 family
BHE83_RS10915	COG5295	Hep Hag repeat protein
BHE83_RS10920	COG1404	Belongs to the peptidase S8 family
BHE83_RS10925	COG5295	Hep Hag repeat protein
BHE83_RS10930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BHE83_RS10930	COG0047	phosphoribosylformylglycinamidine synthase activity
BHE83_RS10935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BHE83_RS10940	COG4974	Belongs to the 'phage' integrase family
BHE83_RS10955	COG0795	lipopolysaccharide-transporting ATPase activity
BHE83_RS10965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BHE83_RS10980	COG0525	valine-tRNA ligase activity
BHE83_RS11015	COG1183	phosphatidylcholine synthase activity
BHE83_RS11025	COG0442	prolyl-tRNA aminoacylation
BHE83_RS11040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BHE83_RS11045	COG1127	ABC transporter
BHE83_RS11050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BHE83_RS11050	COG3218	ABC-type transport auxiliary lipoprotein component
BHE83_RS11075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BHE83_RS11080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BHE83_RS11085	COG0662	Cupin 2, conserved barrel domain protein
BHE83_RS11085	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BHE83_RS11115	COG2086	electron transfer activity
BHE83_RS11130	COG0463	Glycosyl transferase, family 2
BHE83_RS11155	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BHE83_RS11160	COG0438	transferase activity, transferring glycosyl groups
BHE83_RS11180	COG0438	transferase activity, transferring glycosyl groups
BHE83_RS11185	COG0626	cystathionine gamma-synthase activity
BHE83_RS11215	COG0625	glutathione transferase activity
BHE83_RS11225	COG0513	Belongs to the DEAD box helicase family
BHE83_RS11230	COG0720	synthase
BHE83_RS11240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BHE83_RS11245	COG1956	GAF domain-containing protein
BHE83_RS11260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BHE83_RS11265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BHE83_RS11280	COG0339	signal peptide processing
BHE83_RS11330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BHE83_RS11335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_RS11340	COG1136	(ABC) transporter
BHE83_RS11345	COG0577	efflux transmembrane transporter activity
BHE83_RS11365	COG4191	Histidine kinase
BHE83_RS11370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BHE83_RS11385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BHE83_RS11390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BHE83_RS11395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BHE83_RS11400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BHE83_RS11405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BHE83_RS11410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BHE83_RS11420	COG0356	it plays a direct role in the translocation of protons across the membrane
BHE83_RS11440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHE83_RS11450	COG0508	dehydrogenase complex catalyzes the overall conversion of
BHE83_RS11495	COG2011	ABC-type metal ion transport system permease component
BHE83_RS11500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BHE83_RS11505	COG0697	spore germination
BHE83_RS11510	COG1666	GTP binding
BHE83_RS11520	COG2198	Histidine kinase
BHE83_RS11520	COG0784	Response regulator, receiver
BHE83_RS11520	COG5002	protein histidine kinase activity
BHE83_RS11545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BHE83_RS11550	COG1187	pseudouridine synthase activity
BHE83_RS11555	COG2813	Specifically methylates the guanine in position
BHE83_RS11575	COG2205	protein histidine kinase activity
BHE83_RS11575	COG2202	Pas domain
BHE83_RS11595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BHE83_RS11600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHE83_RS11655	COG0842	Transport permease protein
BHE83_RS11660	COG1131	(ABC) transporter
BHE83_RS11665	COG0025	NhaP-type Na H and K H
BHE83_RS11670	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BHE83_RS11675	COG1573	uracil-dna glycosylase
BHE83_RS11685	COG3384	dioxygenase
BHE83_RS11690	COG0583	DNA-binding transcription factor activity
BHE83_RS11715	COG3590	peptidase
BHE83_RS11730	COG0531	amino acid
BHE83_RS11745	COG2972	Histidine kinase
BHE83_RS11760	COG3685	Protein conserved in bacteria
BHE83_RS11765	COG3546	catalase activity
BHE83_RS11805	COG1271	oxidase subunit
BHE83_RS11810	COG1294	oxidase, subunit
BHE83_RS11825	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS11830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BHE83_RS11850	COG1132	(ABC) transporter
BHE83_RS11865	COG1063	alcohol dehydrogenase
BHE83_RS11940	COG0251	oxidation-reduction process
BHE83_RS11960	COG0583	DNA-binding transcription factor activity
BHE83_RS11965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BHE83_RS11995	COG0659	secondary active sulfate transmembrane transporter activity
BHE83_RS12000	COG0038	chloride channel
BHE83_RS12010	COG0024	Methionine aminopeptidase
BHE83_RS12025	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS12080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BHE83_RS12085	COG1490	D-aminoacyl-tRNA deacylase activity
BHE83_RS12090	COG1560	Kdo2-lipid A biosynthetic process
BHE83_RS12145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BHE83_RS12145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BHE83_RS12150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BHE83_RS12155	COG0242	peptide deformylase activity
BHE83_RS12160	COG1652	LysM domain
BHE83_RS12165	COG0758	DNA mediated transformation
BHE83_RS12170	COG2922	Belongs to the Smg family
BHE83_RS12185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BHE83_RS12185	COG1754	DNA topoisomerase type I activity
BHE83_RS12190	COG0009	L-threonylcarbamoyladenylate synthase
BHE83_RS12205	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS12215	COG0616	signal peptide processing
BHE83_RS12220	COG0534	Mate efflux family protein
BHE83_RS12240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BHE83_RS12260	COG1252	NADH dehydrogenase
BHE83_RS12265	COG2860	membrane
BHE83_RS12270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BHE83_RS12275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BHE83_RS12280	COG2201	protein-glutamate methylesterase activity
BHE83_RS12285	COG2177	Part of the ABC transporter FtsEX involved in
BHE83_RS12290	COG2884	Cell division ATP-binding protein ftsE
BHE83_RS12295	COG0513	Belongs to the DEAD box helicase family
BHE83_RS12300	COG3118	belongs to the thioredoxin family
BHE83_RS12305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BHE83_RS12315	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BHE83_RS12320	COG0583	DNA-binding transcription factor activity
BHE83_RS12340	COG1652	LysM domain
BHE83_RS12345	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BHE83_RS12345	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BHE83_RS12350	COG1473	amidohydrolase
BHE83_RS12355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_RS12360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BHE83_RS12370	COG5383	Protein conserved in bacteria
BHE83_RS12410	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BHE83_RS12415	COG3023	N-Acetylmuramoyl-L-alanine amidase
BHE83_RS12425	COG4948	Mandelate Racemase Muconate Lactonizing
BHE83_RS12435	COG0531	amino acid
BHE83_RS12450	COG4682	membrane
BHE83_RS12455	COG2133	pyrroloquinoline quinone binding
BHE83_RS12465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BHE83_RS12470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BHE83_RS12480	COG1610	YqeY-like protein
BHE83_RS12485	COG1295	ribonuclease BN
BHE83_RS12490	COG0358	DNA primase activity
BHE83_RS12505	COG0109	protoheme IX farnesyltransferase activity
BHE83_RS12535	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BHE83_RS12545	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BHE83_RS12585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BHE83_RS12590	COG0739	heme binding
BHE83_RS12595	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BHE83_RS12605	COG2223	nitrite transmembrane transporter activity
BHE83_RS12610	COG0708	Exodeoxyribonuclease III
BHE83_RS12615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BHE83_RS12625	COG1192	Involved in chromosome partitioning
BHE83_RS12630	COG1475	DNA binding
BHE83_RS12645	COG0463	Glycosyl transferase, family 2
BHE83_RS12665	COG0756	dUTP diphosphatase activity
BHE83_RS12670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BHE83_RS12675	COG2003	Belongs to the UPF0758 family
BHE83_RS12680	COG0018	arginyl-trna synthetase
BHE83_RS12695	COG4221	oxidoreductase activity
BHE83_RS12720	COG1166	arginine decarboxylase activity
BHE83_RS12725	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BHE83_RS12750	COG3291	Pkd domain containing protein
BHE83_RS12750	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BHE83_RS12765	COG0606	chelatase, subunit chli
BHE83_RS12780	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BHE83_RS12820	COG1690	Belongs to the RtcB family
BHE83_RS12860	COG1090	epimerase
BHE83_RS12870	COG0642	Histidine kinase
BHE83_RS12890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHE83_RS12910	COG0628	permease
BHE83_RS12915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BHE83_RS12920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BHE83_RS12935	COG0753	catalase activity
BHE83_RS12950	COG2197	response regulator
BHE83_RS12955	COG4585	Histidine kinase
BHE83_RS12960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_RS12965	COG1136	(ABC) transporter
BHE83_RS12990	COG0697	spore germination
BHE83_RS13005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHE83_RS13010	COG0180	Tryptophanyl-tRNA synthetase
BHE83_RS13015	COG3237	CsbD-like
BHE83_RS13055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BHE83_RS13075	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BHE83_RS13080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BHE83_RS13080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BHE83_RS13120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BHE83_RS13145	COG1199	ATP-dependent helicase activity
BHE83_RS13160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BHE83_RS13210	COG0625	glutathione transferase activity
BHE83_RS13245	COG4555	ABC transporter
BHE83_RS13255	COG1476	TRANSCRIPTIONal
BHE83_RS13280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BHE83_RS13285	COG1131	(ABC) transporter
BHE83_RS13290	COG0842	Transport permease protein
BHE83_RS13295	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BHE83_RS13320	COG0716	FMN binding
BHE83_RS13325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BHE83_RS13330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BHE83_RS13340	COG0045	succinate-CoA ligase (ADP-forming) activity
BHE83_RS13340	COG1042	CoA-binding domain protein
BHE83_RS13340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BHE83_RS13345	COG2239	Acts as a magnesium transporter
BHE83_RS13370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BHE83_RS13375	COG3387	PFAM Glycoside hydrolase 15-related
BHE83_RS13385	COG3100	YcgL domain-containing protein
BHE83_RS13390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BHE83_RS13400	COG0463	Glycosyl transferase, family 2
BHE83_RS13410	COG3039	Transposase
BHE83_RS13425	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS13465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BHE83_RS13480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BHE83_RS13515	COG0408	coproporphyrinogen oxidase activity
BHE83_RS13555	COG0515	serine threonine protein kinase
BHE83_RS13560	COG0631	protein serine/threonine phosphatase activity
BHE83_RS13585	COG0667	Aldo Keto reductase
BHE83_RS13590	COG0583	DNA-binding transcription factor activity
BHE83_RS13685	COG2963	transposase activity
BHE83_RS13755	COG0210	DNA helicase
BHE83_RS13770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHE83_RS13775	COG0583	DNA-binding transcription factor activity
BHE83_RS13780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BHE83_RS13790	COG2159	amidohydrolase
BHE83_RS13815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_RS13835	COG0357	Ribosomal RNA small subunit methyltransferase G
BHE83_RS13840	COG3540	Alkaline phosphatase
BHE83_RS13850	COG2091	lysine biosynthetic process via aminoadipic acid
BHE83_RS13870	COG0708	Exodeoxyribonuclease III
BHE83_RS13880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BHE83_RS13885	COG3162	membrane
BHE83_RS13895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BHE83_RS13925	COG3507	Belongs to the glycosyl hydrolase 43 family
BHE83_RS13945	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS13950	COG0179	Fumarylacetoacetate (FAA) hydrolase
BHE83_RS13955	COG4948	Mandelate Racemase Muconate Lactonizing
BHE83_RS13960	COG3254	rhamnose metabolic process
BHE83_RS13965	COG0738	Major facilitator superfamily
BHE83_RS13970	COG1414	Transcriptional regulator
BHE83_RS13975	COG1971	Probably functions as a manganese efflux pump
BHE83_RS13980	COG2205	protein histidine kinase activity
BHE83_RS13990	COG3459	Glycosyltransferase 36 associated
BHE83_RS13995	COG2211	Major facilitator Superfamily
BHE83_RS14000	COG3265	gluconokinase activity
BHE83_RS14025	COG2911	Protein conserved in bacteria
BHE83_RS14030	COG0729	surface antigen
BHE83_RS14045	COG0457	Tetratricopeptide repeat
BHE83_RS14055	COG0752	glycyl-tRNA synthetase alpha subunit
BHE83_RS14060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BHE83_RS14070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BHE83_RS14070	COG0519	Catalyzes the synthesis of GMP from XMP
BHE83_RS14080	COG0805	protein transport
BHE83_RS14085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BHE83_RS14090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BHE83_RS14100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BHE83_RS14120	COG2974	May be involved in recombination
BHE83_RS14125	COG0037	tRNA processing
BHE83_RS14130	COG2115	Belongs to the xylose isomerase family
BHE83_RS14140	COG3661	Belongs to the glycosyl hydrolase 67 family
BHE83_RS14150	COG4948	Mandelate Racemase Muconate Lactonizing
BHE83_RS14160	COG1472	Belongs to the glycosyl hydrolase 3 family
BHE83_RS14165	COG0246	Mannitol dehydrogenase
BHE83_RS14210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BHE83_RS14235	COG3386	PFAM SMP-30 Gluconolaconase
BHE83_RS14245	COG3250	beta-galactosidase activity
BHE83_RS14250	COG1904	glucuronate isomerase
BHE83_RS14255	COG3693	PFAM glycoside hydrolase, family 10
BHE83_RS14265	COG3693	PFAM glycoside hydrolase, family 10
BHE83_RS14280	COG2211	Major facilitator Superfamily
BHE83_RS14315	COG0604	alcohol dehydrogenase
BHE83_RS14315	COG3321	synthase
BHE83_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS14325	COG2937	Belongs to the GPAT DAPAT family
BHE83_RS14360	COG0284	orotidine-5'-phosphate decarboxylase activity
BHE83_RS14365	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BHE83_RS14370	COG3132	Protein of unknown function, DUF480
BHE83_RS14385	COG0210	DNA helicase
BHE83_RS14390	COG1435	thymidine kinase activity
BHE83_RS14400	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BHE83_RS14410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BHE83_RS14440	COG3135	benzoate transporter
BHE83_RS14460	COG0676	glucose-6-phosphate 1-epimerase activity
BHE83_RS14470	COG3012	SEC-C Motif Domain Protein
BHE83_RS14475	COG0730	response to heat
BHE83_RS14495	COG0302	gtp cyclohydrolase
BHE83_RS14510	COG1566	PFAM secretion protein HlyD family protein
BHE83_RS14520	COG1289	transmembrane transporter activity
BHE83_RS14525	COG0477	Major facilitator Superfamily
BHE83_RS14545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHE83_RS14615	COG0564	pseudouridine synthase activity
BHE83_RS14650	COG1309	transcriptional regulator
BHE83_RS14660	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS14700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BHE83_RS14705	COG1074	ATP-dependent DNA helicase activity
BHE83_RS14710	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BHE83_RS14745	COG1127	ABC transporter
BHE83_RS14750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BHE83_RS14755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BHE83_RS14770	COG2853	Lipoprotein
BHE83_RS14780	COG0386	Belongs to the glutathione peroxidase family
BHE83_RS14790	COG1322	Protein conserved in bacteria
BHE83_RS14795	COG0604	alcohol dehydrogenase
BHE83_RS14820	COG0531	amino acid
BHE83_RS14825	COG3537	Alpha-1,2-mannosidase
BHE83_RS14830	COG4206	TonB-dependent receptor
BHE83_RS14840	COG3706	GGDEF domain
BHE83_RS14845	COG3835	regulator
BHE83_RS14850	COG1929	Belongs to the glycerate kinase type-1 family
BHE83_RS14855	COG2271	Major facilitator Superfamily
BHE83_RS14870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BHE83_RS14875	COG0861	Integral membrane protein TerC family
BHE83_RS14885	COG0584	glycerophosphoryl diester phosphodiesterase
BHE83_RS14905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BHE83_RS14910	COG0726	polysaccharide deacetylase
BHE83_RS14915	COG0706	membrane insertase activity
BHE83_RS14920	COG0594	ribonuclease P activity
BHE83_RS14930	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BHE83_RS14940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BHE83_RS14945	COG0187	DNA topoisomerase II activity
BHE83_RS14955	COG0501	Belongs to the peptidase M48B family
BHE83_RS14995	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BHE83_RS15005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHE83_RS15050	COG0793	Belongs to the peptidase S41A family
BHE83_RS15055	COG4942	peptidase
BHE83_RS15065	COG2234	aminopeptidase activity
BHE83_RS15075	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BHE83_RS15080	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BHE83_RS15090	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BHE83_RS15095	COG1064	alcohol dehydrogenase
BHE83_RS15100	COG0493	'glutamate synthase
BHE83_RS15105	COG0067	glutamate synthase
BHE83_RS15105	COG0069	glutamate synthase activity
BHE83_RS15105	COG0070	glutamate synthase
BHE83_RS15190	COG1111	helicase
BHE83_RS15190	COG1205	dead DEAH box helicase
BHE83_RS15195	COG1272	protein, Hemolysin III
BHE83_RS15215	COG0300	oxidoreductase activity
BHE83_RS15220	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS15225	COG0515	serine threonine protein kinase
BHE83_RS15225	COG2815	serine threonine protein kinase
BHE83_RS15235	COG2963	transposase activity
BHE83_RS15260	COG3237	CsbD-like
BHE83_RS15310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHE83_RS15315	COG0477	Major facilitator Superfamily
BHE83_RS15355	COG0714	Associated with various cellular activities
BHE83_RS15400	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BHE83_RS15420	COG4772	TonB-dependent receptor
BHE83_RS15440	COG1012	belongs to the aldehyde dehydrogenase family
BHE83_RS15465	COG1304	FMN binding
BHE83_RS15480	COG1755	Isoprenylcysteine carboxyl methyltransferase
BHE83_RS15485	COG4585	Histidine kinase
BHE83_RS15490	COG2197	response regulator
BHE83_RS15510	COG3710	Transcriptional regulator
BHE83_RS15515	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BHE83_RS15525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BHE83_RS15545	COG2963	transposase activity
BHE83_RS15555	COG3039	Transposase
BHE83_RS15595	COG0366	Alpha amylase catalytic
BHE83_RS15600	COG0366	Alpha amylase catalytic
BHE83_RS15605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BHE83_RS15620	COG2272	Belongs to the type-B carboxylesterase lipase family
BHE83_RS15625	COG0657	acetylesterase activity
BHE83_RS15625	COG2755	lipolytic protein G-D-S-L family
BHE83_RS15635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BHE83_RS15650	COG3507	Belongs to the glycosyl hydrolase 43 family
BHE83_RS15655	COG1609	Transcriptional regulator
BHE83_RS15660	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BHE83_RS15665	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS15675	COG2755	lipolytic protein G-D-S-L family
BHE83_RS15685	COG3186	Phenylalanine-4-hydroxylase
BHE83_RS15690	COG1522	sequence-specific DNA binding
BHE83_RS15700	COG1752	Esterase of the alpha-beta hydrolase superfamily
BHE83_RS15705	COG1473	amidohydrolase
BHE83_RS15715	COG1119	ATPase activity
BHE83_RS15730	COG1125	glycine betaine transport
BHE83_RS15745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BHE83_RS15775	COG0489	protein tyrosine kinase activity
BHE83_RS15780	COG2062	phosphohistidine phosphatase, SixA
BHE83_RS15790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHE83_RS15835	COG1968	undecaprenyl-diphosphatase activity
BHE83_RS15840	COG0174	glutamine synthetase
BHE83_RS15845	COG0347	Belongs to the P(II) protein family
BHE83_RS15850	COG0004	ammonium transporteR
BHE83_RS15855	COG3852	Histidine kinase
BHE83_RS15860	COG2204	response regulator
BHE83_RS15865	COG2032	superoxide dismutase activity
BHE83_RS15870	COG2032	superoxide dismutase activity
BHE83_RS15875	COG0346	lactoylglutathione lyase activity
BHE83_RS15885	COG0183	Belongs to the thiolase family
BHE83_RS15920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BHE83_RS15925	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BHE83_RS15930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BHE83_RS16025	COG2963	transposase activity
BHE83_RS16065	COG0028	Belongs to the TPP enzyme family
BHE83_RS16070	COG4191	Histidine kinase
BHE83_RS16095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BHE83_RS16110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHE83_RS16115	COG3177	Filamentation induced by cAMP protein fic
BHE83_RS16120	COG0596	Alpha beta hydrolase
BHE83_RS16125	COG0727	PFAM Uncharacterised protein family (UPF0153)
BHE83_RS16130	COG0318	PFAM AMP-dependent synthetase and ligase
BHE83_RS16135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BHE83_RS16145	COG1181	Belongs to the D-alanine--D-alanine ligase family
BHE83_RS16160	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BHE83_RS16170	COG0564	pseudouridine synthase activity
BHE83_RS16190	COG1446	asparaginase
BHE83_RS16195	COG0339	signal peptide processing
BHE83_RS16230	COG0475	glutathione-regulated potassium exporter activity
BHE83_RS16235	COG0583	DNA-binding transcription factor activity
BHE83_RS16240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BHE83_RS16245	COG2224	Isocitrate lyase
BHE83_RS16275	COG4770	biotin carboxylase activity
BHE83_RS16280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BHE83_RS16285	COG1960	acyl-CoA dehydrogenase activity
BHE83_RS16345	COG0523	cobalamin synthesis protein
BHE83_RS16360	COG0697	spore germination
BHE83_RS16370	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BHE83_RS16375	COG1846	Transcriptional regulator
BHE83_RS16380	COG1764	response to oxidative stress
BHE83_RS16400	COG2130	NADP-dependent
BHE83_RS16415	COG1187	pseudouridine synthase activity
BHE83_RS16425	COG1643	Atp-dependent helicase
BHE83_RS16435	COG4807	Protein conserved in bacteria
BHE83_RS16440	COG2351	hydroxyisourate hydrolase activity
BHE83_RS16445	COG2072	flavoprotein involved in K transport
BHE83_RS16465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BHE83_RS16480	COG0583	DNA-binding transcription factor activity
BHE83_RS16520	COG2252	PERMEase
BHE83_RS16540	COG0084	hydrolase, TatD family'
BHE83_RS16555	COG0583	DNA-binding transcription factor activity
BHE83_RS16560	COG2814	Major facilitator Superfamily
BHE83_RS16570	COG2267	carboxylic ester hydrolase activity
BHE83_RS16575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BHE83_RS16580	COG1902	pentaerythritol trinitrate reductase activity
BHE83_RS16600	COG0745	RESPONSE REGULATOR receiver
BHE83_RS16605	COG2205	protein histidine kinase activity
BHE83_RS16610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_RS16635	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BHE83_RS16640	COG0583	DNA-binding transcription factor activity
BHE83_RS16675	COG0702	epimerase
BHE83_RS16680	COG1733	regulation of RNA biosynthetic process
BHE83_RS16705	COG2801	Transposase and inactivated derivatives
BHE83_RS16725	COG0129	dihydroxy-acid dehydratase activity
BHE83_RS16745	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BHE83_RS16800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BHE83_RS16805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BHE83_RS16830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BHE83_RS16835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BHE83_RS16845	COG3485	protocatechuate 3,4-dioxygenase
BHE83_RS16850	COG3485	protocatechuate 3,4-dioxygenase
BHE83_RS16860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BHE83_RS16865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BHE83_RS16880	COG1414	Transcriptional regulator
BHE83_RS16890	COG0657	acetylesterase activity
BHE83_RS16900	COG0445	tRNA wobble uridine modification
BHE83_RS16910	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BHE83_RS16935	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS16940	COG2267	carboxylic ester hydrolase activity
BHE83_RS16950	COG0156	8-amino-7-oxononanoate synthase activity
BHE83_RS16955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BHE83_RS16960	COG1040	competence protein
BHE83_RS16965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BHE83_RS17065	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BHE83_RS17125	COG2963	transposase activity
BHE83_RS17130	COG2801	Transposase and inactivated derivatives
BHE83_RS17155	COG1511	domain protein
BHE83_RS17155	COG3264	Mechanosensitive ion channel
BHE83_RS17160	COG1368	sulfuric ester hydrolase activity
BHE83_RS17165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BHE83_RS17170	COG2354	Protein conserved in bacteria
BHE83_RS17180	COG0297	glycogen (starch) synthase activity
BHE83_RS17185	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BHE83_RS17190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BHE83_RS17215	COG0702	epimerase
BHE83_RS17220	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS17250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BHE83_RS17255	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS17265	COG0513	Belongs to the DEAD box helicase family
BHE83_RS17275	COG0508	dehydrogenase complex catalyzes the overall conversion of
BHE83_RS17290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BHE83_RS17300	COG3483	tryptophan 2,3-dioxygenase activity
BHE83_RS17305	COG3104	oligopeptide transport
BHE83_RS17325	COG2852	Protein conserved in bacteria
BHE83_RS17330	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BHE83_RS17350	COG1320	monovalent cation:proton antiporter activity
BHE83_RS17355	COG2212	antiporter activity
BHE83_RS17360	COG1863	multisubunit Na H antiporter MnhE subunit
BHE83_RS17365	COG0651	ATP synthesis coupled electron transport
BHE83_RS17370	COG1006	Multisubunit Na H antiporter MnhC subunit
BHE83_RS17375	COG2111	Na H antiporter
BHE83_RS17375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BHE83_RS17395	COG3179	chitinase
BHE83_RS17415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BHE83_RS17420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BHE83_RS17430	COG0456	acetyltransferase
BHE83_RS17435	COG1597	lipid kinase activity
BHE83_RS17455	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BHE83_RS17490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BHE83_RS17495	COG0134	indole-3-glycerol-phosphate synthase activity
BHE83_RS17505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHE83_RS17510	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BHE83_RS17520	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BHE83_RS17530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BHE83_RS17545	COG1051	belongs to the nudix hydrolase family
BHE83_RS17585	COG0316	Belongs to the HesB IscA family
BHE83_RS17600	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BHE83_RS17625	COG2814	Major facilitator Superfamily
BHE83_RS17630	COG1289	transmembrane transporter activity
BHE83_RS17635	COG0151	Belongs to the GarS family
BHE83_RS17645	COG0138	bifunctional purine biosynthesis protein purh
BHE83_RS17650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BHE83_RS17655	COG2267	carboxylic ester hydrolase activity
BHE83_RS17660	COG0671	phosphoesterase, PA-phosphatase related
BHE83_RS17660	COG2453	phosphatase
BHE83_RS17685	COG4589	Belongs to the CDS family
BHE83_RS17690	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BHE83_RS17715	COG2264	protein methyltransferase activity
BHE83_RS17735	COG0439	Biotin carboxylase
BHE83_RS17745	COG0511	ligase activity, forming carbon-carbon bonds
BHE83_RS17750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BHE83_RS17760	COG1324	tolerance protein
BHE83_RS17770	COG2356	endonuclease I
BHE83_RS17785	COG0459	protein refolding
BHE83_RS17800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BHE83_RS17825	COG3386	PFAM SMP-30 Gluconolaconase
BHE83_RS17835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BHE83_RS17840	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BHE83_RS17875	COG0778	Nitroreductase
BHE83_RS17880	COG2353	YceI-like domain
BHE83_RS17915	COG3052	prosthetic group binding
BHE83_RS17940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BHE83_RS17950	COG1802	Transcriptional regulator
BHE83_RS17955	COG0546	phosphoglycolate phosphatase activity
BHE83_RS17995	COG0464	growth
BHE83_RS18025	COG2963	transposase activity
BHE83_RS18040	COG3039	Transposase
BHE83_RS18055	COG4221	oxidoreductase activity
BHE83_RS18065	COG2963	transposase activity
BHE83_RS18070	COG4221	oxidoreductase activity
BHE83_RS18110	COG4221	oxidoreductase activity
BHE83_RS18120	COG0435	Glutathione S-transferase
BHE83_RS18170	COG1959	2 iron, 2 sulfur cluster binding
BHE83_RS18195	COG0697	spore germination
BHE83_RS18210	COG1113	amino acid transport
BHE83_RS18220	COG0598	Magnesium transport protein CorA
BHE83_RS18230	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
BHE83_RS18265	COG0840	transmembrane signaling receptor activity
BHE83_RS18270	COG5297	Belongs to the glycosyl hydrolase family 6
BHE83_RS18270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BHE83_RS18275	COG0659	secondary active sulfate transmembrane transporter activity
BHE83_RS18290	COG2943	transferase activity, transferring hexosyl groups
BHE83_RS18300	COG3275	phosphorelay sensor kinase activity
BHE83_RS18310	COG0181	hydroxymethylbilane synthase activity
BHE83_RS18345	COG1505	serine-type exopeptidase activity
BHE83_RS18350	COG0436	Aminotransferase
BHE83_RS18360	COG2832	Protein of unknown function (DUF454)
BHE83_RS18370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BHE83_RS18380	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BHE83_RS18385	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BHE83_RS18390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BHE83_RS18420	COG3300	MHYT domain
BHE83_RS18420	COG5001	Diguanylate cyclase
BHE83_RS18425	COG0308	aminopeptidase N
BHE83_RS18450	COG2801	Transposase and inactivated derivatives
BHE83_RS18485	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BHE83_RS18495	COG3284	Transcriptional regulator
BHE83_RS18500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BHE83_RS18505	COG1077	Cell shape determining protein MreB Mrl
BHE83_RS18510	COG1792	Involved in formation and maintenance of cell shape
BHE83_RS18525	COG0772	Belongs to the SEDS family
BHE83_RS18535	COG2951	lytic endotransglycosylase activity
BHE83_RS18540	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BHE83_RS18545	COG1686	Belongs to the peptidase S11 family
BHE83_RS18555	COG2921	Belongs to the UPF0250 family
BHE83_RS18560	COG0321	lipoyl(octanoyl) transferase activity
BHE83_RS18565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BHE83_RS18580	COG0583	DNA-binding transcription factor activity
BHE83_RS18590	COG1056	cytidyltransferase-related domain
BHE83_RS18590	COG1051	belongs to the nudix hydrolase family
BHE83_RS18625	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BHE83_RS18630	COG0673	inositol 2-dehydrogenase activity
BHE83_RS18635	COG2823	Periplasmic or secreted lipoprotein
BHE83_RS18640	COG4251	negative regulation of phosphorylation
BHE83_RS18645	COG0784	Response regulator, receiver
BHE83_RS18650	COG4191	Histidine kinase
BHE83_RS18655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BHE83_RS18710	COG1459	type II secretion system
BHE83_RS18730	COG4795	General secretion pathway protein
BHE83_RS18755	COG2188	Transcriptional regulator
BHE83_RS18765	COG1609	Transcriptional regulator
BHE83_RS18770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BHE83_RS18775	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BHE83_RS18790	COG0617	tRNA 3'-terminal CCA addition
BHE83_RS18795	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BHE83_RS18800	COG1012	belongs to the aldehyde dehydrogenase family
BHE83_RS18805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BHE83_RS18835	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BHE83_RS18845	COG2205	protein histidine kinase activity
BHE83_RS18875	COG3791	Glutathione-dependent formaldehyde-activating
BHE83_RS18890	COG0488	(ABC) transporter
BHE83_RS18900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BHE83_RS18910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BHE83_RS18920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BHE83_RS18920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BHE83_RS18940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BHE83_RS18945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BHE83_RS18950	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BHE83_RS18970	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BHE83_RS18975	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BHE83_RS18985	COG2205	protein histidine kinase activity
BHE83_RS18990	COG0745	RESPONSE REGULATOR receiver
BHE83_RS19000	COG0277	FAD linked oxidase domain protein
BHE83_RS19005	COG1988	membrane-bound metal-dependent
BHE83_RS19010	COG0792	nuclease activity
BHE83_RS19050	COG0275	rRNA processing
BHE83_RS19055	COG3116	cell division
BHE83_RS19070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BHE83_RS19075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BHE83_RS19080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BHE83_RS19090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BHE83_RS19095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BHE83_RS19100	COG1181	Belongs to the D-alanine--D-alanine ligase family
BHE83_RS19105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BHE83_RS19120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BHE83_RS19130	COG0739	heme binding
BHE83_RS19135	COG0653	protein targeting
BHE83_RS19140	COG0494	nUDIX hydrolase
BHE83_RS19150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BHE83_RS19160	COG0604	alcohol dehydrogenase
BHE83_RS19160	COG3321	synthase
BHE83_RS19160	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS19215	COG2226	methyltransferase
BHE83_RS19220	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BHE83_RS19230	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BHE83_RS19270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BHE83_RS19280	COG4106	trans-aconitate 2-methyltransferase activity
BHE83_RS19285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BHE83_RS19295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BHE83_RS19300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BHE83_RS19305	COG0667	Aldo Keto reductase
BHE83_RS19315	COG4771	TonB-dependent receptor
BHE83_RS19335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BHE83_RS19340	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BHE83_RS19350	COG2175	clavaminate synthase activity
BHE83_RS19360	COG4181	ATPase activity
BHE83_RS19375	COG0642	Histidine kinase
BHE83_RS19385	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BHE83_RS19405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BHE83_RS19410	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BHE83_RS19425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BHE83_RS19430	COG2967	ApaG domain
BHE83_RS19435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BHE83_RS19440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BHE83_RS19445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BHE83_RS19450	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BHE83_RS19455	COG0123	including yeast histone deacetylase and acetoin utilization protein
BHE83_RS19460	COG2096	Adenosyltransferase
BHE83_RS19470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BHE83_RS19475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BHE83_RS19505	COG3384	dioxygenase
BHE83_RS19510	COG0583	DNA-binding transcription factor activity
BHE83_RS19515	COG0318	PFAM AMP-dependent synthetase and ligase
BHE83_RS19525	COG1024	Enoyl-CoA hydratase
BHE83_RS19545	COG3386	PFAM SMP-30 Gluconolaconase
BHE83_RS19555	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BHE83_RS19585	COG0697	spore germination
BHE83_RS19595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BHE83_RS19620	COG2197	response regulator
BHE83_RS19630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BHE83_RS19640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BHE83_RS19645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BHE83_RS19650	COG0583	DNA-binding transcription factor activity
BHE83_RS19655	COG3634	alkyl hydroperoxide reductase activity
BHE83_RS19665	COG2890	protein-(glutamine-N5) methyltransferase activity
BHE83_RS19685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BHE83_RS19685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BHE83_RS19700	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BHE83_RS19740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BHE83_RS19745	COG1404	Belongs to the peptidase S8 family
BHE83_RS19750	COG1404	Belongs to the peptidase S8 family
BHE83_RS19755	COG1404	Belongs to the peptidase S8 family
BHE83_RS19760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BHE83_RS19785	COG1295	ribonuclease BN
BHE83_RS19790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHE83_RS19795	COG1254	Belongs to the acylphosphatase family
BHE83_RS19810	COG0521	Mo-molybdopterin cofactor biosynthetic process
BHE83_RS19820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BHE83_RS19825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BHE83_RS19835	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BHE83_RS19840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BHE83_RS19850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BHE83_RS19855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BHE83_RS19860	COG0193	aminoacyl-tRNA hydrolase activity
BHE83_RS19865	COG0012	GTP binding
BHE83_RS19885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BHE83_RS19900	COG0250	Participates in transcription elongation, termination and antitermination
BHE83_RS19905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BHE83_RS19910	COG0081	regulation of translation
BHE83_RS19915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BHE83_RS19920	COG0222	ribosome binding
BHE83_RS19925	COG0085	RNA polymerase activity
BHE83_RS19930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BHE83_RS19935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BHE83_RS19940	COG0049	tRNA binding
BHE83_RS19945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BHE83_RS19950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BHE83_RS19960	COG0051	transcription antitermination factor activity, RNA binding
BHE83_RS19965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BHE83_RS19970	COG0088	Forms part of the polypeptide exit tunnel
BHE83_RS19975	COG0089	rRNA binding
BHE83_RS19980	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BHE83_RS19985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BHE83_RS19995	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BHE83_RS20000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BHE83_RS20005	COG0255	Belongs to the universal ribosomal protein uL29 family
BHE83_RS20010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BHE83_RS20025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BHE83_RS20030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BHE83_RS20035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BHE83_RS20040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BHE83_RS20045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BHE83_RS20055	COG1841	ribosomal large subunit assembly
BHE83_RS20060	COG0200	Binds to the 23S rRNA
BHE83_RS20065	COG0201	protein transport
BHE83_RS20090	COG0203	ribosomal protein L17
BHE83_RS20095	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BHE83_RS20110	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BHE83_RS20120	COG0154	amidase activity
BHE83_RS20130	COG1217	gtp-binding protein TYPA
BHE83_RS20135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BHE83_RS20140	COG0039	L-malate dehydrogenase activity
BHE83_RS20145	COG0625	glutathione transferase activity
BHE83_RS20155	COG1902	pentaerythritol trinitrate reductase activity
BHE83_RS20155	COG0446	pyridine nucleotide-disulphide oxidoreductase
BHE83_RS20165	COG2885	chlorophyll binding
BHE83_RS20185	COG0156	8-amino-7-oxononanoate synthase activity
BHE83_RS20190	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BHE83_RS20195	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BHE83_RS20200	COG4208	sulfate ABC transporter
BHE83_RS20205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BHE83_RS20215	COG1063	alcohol dehydrogenase
BHE83_RS20235	COG0406	alpha-ribazole phosphatase activity
BHE83_RS20240	COG0285	dihydrofolate synthase activity
BHE83_RS20260	COG2833	Protein of unknown function (DUF455)
BHE83_RS20265	COG3291	Pkd domain containing protein
BHE83_RS20275	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BHE83_RS20280	COG0671	phosphoesterase, PA-phosphatase related
BHE83_RS20285	COG0438	transferase activity, transferring glycosyl groups
BHE83_RS20295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BHE83_RS20310	COG4783	chaperone-mediated protein folding
BHE83_RS20325	COG0473	3-isopropylmalate dehydrogenase activity
BHE83_RS20355	COG3852	Histidine kinase
BHE83_RS20365	COG0544	peptidyl-prolyl cis-trans isomerase activity
BHE83_RS20375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BHE83_RS20405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BHE83_RS20415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHE83_RS20425	COG0328	RNA-DNA hybrid ribonuclease activity
BHE83_RS20430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BHE83_RS20435	COG0631	protein serine/threonine phosphatase activity
BHE83_RS20465	COG2963	transposase activity
BHE83_RS20490	COG0859	PFAM glycosyl transferase family 9
BHE83_RS20495	COG3642	lipopolysaccharide core region biosynthetic process
BHE83_RS20500	COG1234	tRNA 3'-trailer cleavage
BHE83_RS20505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BHE83_RS20515	COG0315	cyclic pyranopterin monophosphate synthase activity
BHE83_RS20520	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BHE83_RS20525	COG0314	molybdopterin synthase activity
BHE83_RS20555	COG2963	transposase activity
BHE83_RS20560	COG2801	Transposase and inactivated derivatives
BHE83_RS20585	COG2801	Transposase and inactivated derivatives
BHE83_RS20595	COG0322	excinuclease ABC activity
BHE83_RS20635	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BHE83_RS20640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BHE83_RS20645	COG0537	adenosine 5'-monophosphoramidase activity
BHE83_RS20665	COG0714	Associated with various cellular activities
BHE83_RS20675	COG0424	maF-like protein
BHE83_RS20680	COG2963	transposase activity
BHE83_RS20685	COG2801	Transposase and inactivated derivatives
BHE83_RS20690	COG0424	maF-like protein
BHE83_RS20700	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BHE83_RS20705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHE83_RS20735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BHE83_RS20740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BHE83_RS20770	COG3829	transcription factor binding
BHE83_RS20795	COG2828	Protein conserved in bacteria
BHE83_RS20810	COG2373	Large extracellular alpha-helical protein
BHE83_RS20825	COG4953	penicillin-binding protein 1C
BHE83_RS20855	COG0330	HflC and HflK could
BHE83_RS20860	COG0330	HflC and HflK could
BHE83_RS20870	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BHE83_RS20875	COG0308	aminopeptidase N
BHE83_RS20885	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS20890	COG1309	transcriptional regulator
BHE83_RS20935	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BHE83_RS20945	COG0732	type I restriction modification DNA specificity domain
BHE83_RS20950	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BHE83_RS20980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BHE83_RS20990	COG3387	PFAM Glycoside hydrolase 15-related
BHE83_RS20995	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS21000	COG3537	Alpha-1,2-mannosidase
BHE83_RS21010	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_RS21020	COG0492	ferredoxin-NADP+ reductase activity
BHE83_RS21045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BHE83_RS21050	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BHE83_RS21055	COG2080	2 iron, 2 sulfur cluster binding
BHE83_RS21090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BHE83_RS21110	COG0587	DNA-directed DNA polymerase activity
BHE83_RS21125	COG1297	OPT oligopeptide transporter protein
BHE83_RS21140	COG0823	Involved in the tonB-independent uptake of proteins
BHE83_RS21140	COG1506	peptidase
BHE83_RS21155	COG1917	Cupin 2, conserved barrel domain protein
BHE83_RS21155	COG2207	Transcriptional regulator
BHE83_RS21175	COG0753	catalase activity
BHE83_RS21180	COG0656	L-ascorbic acid biosynthetic process
BHE83_RS21185	COG2272	Belongs to the type-B carboxylesterase lipase family
BHE83_RS21190	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BHE83_RS21190	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BHE83_RS21215	COG2814	Major facilitator Superfamily
BHE83_RS21235	COG2194	sulfuric ester hydrolase activity
BHE83_RS21250	COG0745	RESPONSE REGULATOR receiver
BHE83_RS21255	COG0642	Histidine kinase
BHE83_RS21265	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BHE83_RS21270	COG2894	cell division
BHE83_RS21275	COG0850	regulation of cytokinetic process
BHE83_RS21285	COG4585	Histidine kinase
BHE83_RS21290	COG2197	response regulator
BHE83_RS21305	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BHE83_RS21330	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BHE83_RS21345	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BHE83_RS21360	COG1595	DNA-templated transcription, initiation
BHE83_RS21375	COG1024	Enoyl-CoA hydratase
BHE83_RS21385	COG0824	Thioesterase
BHE83_RS21390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BHE83_RS21395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BHE83_RS21400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BHE83_RS21405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BHE83_RS21410	COG0268	Binds directly to 16S ribosomal RNA
BHE83_RS21420	COG0196	riboflavin kinase activity
BHE83_RS21425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BHE83_RS21430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BHE83_RS21435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BHE83_RS21450	COG3039	Transposase
BHE83_RS21485	COG2963	transposase activity
BHE83_RS21525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BHE83_RS21530	COG1845	cytochrome c oxidase, subunit III
BHE83_RS21535	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BHE83_RS21550	COG3152	Membrane
BHE83_RS21560	COG2207	Transcriptional regulator
BHE83_RS21565	COG0326	Molecular chaperone. Has ATPase activity
BHE83_RS21575	COG1366	Belongs to the anti-sigma-factor antagonist family
BHE83_RS21580	COG1366	Belongs to the anti-sigma-factor antagonist family
BHE83_RS21585	COG2172	sigma factor antagonist activity
BHE83_RS21610	COG4771	TonB-dependent receptor
BHE83_RS21620	COG5507	3-demethylubiquinone-9 3-methyltransferase
BHE83_RS21625	COG2205	protein histidine kinase activity
BHE83_RS21635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BHE83_RS21640	COG4999	Histidine kinase
BHE83_RS21640	COG3850	Histidine kinase
BHE83_RS21640	COG3437	response regulator, receiver
BHE83_RS21640	COG2205	protein histidine kinase activity
BHE83_RS21645	COG4191	Histidine kinase
BHE83_RS21645	COG0784	Response regulator, receiver
BHE83_RS21670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BHE83_RS21675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BHE83_RS21685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BHE83_RS21690	COG0228	four-way junction DNA binding
BHE83_RS21695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BHE83_RS21700	COG0336	Belongs to the RNA methyltransferase TrmD family
BHE83_RS21705	COG0335	large ribosomal subunit rRNA binding
BHE83_RS21710	COG0534	Mate efflux family protein
BHE83_RS21735	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BHE83_RS21745	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BHE83_RS21760	COG2801	Transposase and inactivated derivatives
BHE83_RS21765	COG2963	transposase activity
BHE83_RS21780	COG3250	beta-galactosidase activity
BHE83_RS21785	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BHE83_RS21805	COG1960	acyl-CoA dehydrogenase activity
BHE83_RS21810	COG1024	Enoyl-CoA hydratase
BHE83_RS21830	COG1024	Enoyl-CoA hydratase
BHE83_RS21830	COG1250	3-hydroxyacyl-CoA dehydrogenase
BHE83_RS21845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHE83_RS21850	COG0481	GTPase activity
BHE83_RS21865	COG0571	ribonuclease III activity
BHE83_RS21870	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BHE83_RS21880	COG1381	Involved in DNA repair and RecF pathway recombination
BHE83_RS21895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BHE83_RS21900	COG2954	triphosphatase activity
BHE83_RS21905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BHE83_RS21910	COG1233	COG1233 Phytoene dehydrogenase and related
BHE83_RS21915	COG3046	protein related to deoxyribodipyrimidine photolyase
BHE83_RS21920	COG1472	Belongs to the glycosyl hydrolase 3 family
BHE83_RS21925	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BHE83_RS21930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BHE83_RS21935	COG1278	Cold shock
BHE83_RS21950	COG1201	RNA secondary structure unwinding
BHE83_RS21955	COG1793	dna ligase
BHE83_RS21965	COG1793	dna ligase
BHE83_RS21965	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BHE83_RS22000	COG0183	Belongs to the thiolase family
BHE83_RS22025	COG1451	nucleotide metabolic process
BHE83_RS22030	COG5487	UPF0391 membrane protein
BHE83_RS22040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BHE83_RS22060	COG1077	Cell shape determining protein MreB Mrl
BHE83_RS22075	COG2824	Alkylphosphonate utilization operon protein PhnA
BHE83_RS22080	COG1902	pentaerythritol trinitrate reductase activity
BHE83_RS22085	COG2814	Major facilitator Superfamily
BHE83_RS22120	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BHE83_RS22120	COG0392	lysyltransferase activity
BHE83_RS22130	COG0251	oxidation-reduction process
BHE83_RS22135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BHE83_RS22150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BHE83_RS22175	COG1595	DNA-templated transcription, initiation
BHE83_RS22195	COG2878	Part of a membrane complex involved in electron transport
BHE83_RS22205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BHE83_RS22205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BHE83_RS22225	COG0346	lactoylglutathione lyase activity
BHE83_RS22240	COG0833	amino acid
BHE83_RS22245	COG2040	homocysteine
BHE83_RS22255	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BHE83_RS22275	COG1695	Transcriptional regulator
BHE83_RS22295	COG1981	membrane
BHE83_RS22310	COG0825	malonyl-CoA metabolic process
BHE83_RS22315	COG0587	DNA-directed DNA polymerase activity
BHE83_RS22325	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BHE83_RS22330	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BHE83_RS22335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BHE83_RS22340	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BHE83_RS22355	COG0750	zinc metalloprotease
BHE83_RS22385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BHE83_RS22720	COG0415	Belongs to the DNA photolyase family
BHE83_RS22820	COG1404	Belongs to the peptidase S8 family
BHE83_RS22880	COG0443	Heat shock 70 kDa protein
BHE83_RS23090	COG0646	methionine synthase
BHE83_RS23090	COG1410	methionine synthase
BHE83_RS23345	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BHE83_RS23385	COG0367	asparagine synthase
BHE83_RS23525	COG0052	Belongs to the universal ribosomal protein uS2 family