locus-tag	class	description
IS_RS00105	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IS_RS00170	COG0187	DNA topoisomerase II activity
IS_RS00685	COG1205	dead DEAH box helicase
IS_RS00685	COG1111	helicase
IS_RS01000	COG2204	response regulator
IS_RS01045	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IS_RS01220	COG2755	lipolytic protein G-D-S-L family
IS_RS01220	COG0657	acetylesterase activity
IS_RS01265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IS_RS01275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IS_RS01280	COG0187	DNA topoisomerase II activity
IS_RS01290	COG0501	Belongs to the peptidase M48B family
IS_RS01330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IS_RS01340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS_RS01385	COG0793	Belongs to the peptidase S41A family
IS_RS01390	COG4942	peptidase
IS_RS01400	COG2234	aminopeptidase activity
IS_RS01410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IS_RS01415	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IS_RS01425	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IS_RS01430	COG1064	alcohol dehydrogenase
IS_RS01435	COG0493	'glutamate synthase
IS_RS01440	COG0070	glutamate synthase
IS_RS01440	COG0067	glutamate synthase
IS_RS01440	COG0069	glutamate synthase activity
IS_RS01520	COG1111	helicase
IS_RS01520	COG1205	dead DEAH box helicase
IS_RS01525	COG1272	protein, Hemolysin III
IS_RS01540	COG0300	oxidoreductase activity
IS_RS01545	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS01550	COG0515	serine threonine protein kinase
IS_RS01550	COG2815	serine threonine protein kinase
IS_RS01560	COG2963	transposase activity
IS_RS01585	COG3237	CsbD-like
IS_RS01635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS_RS01640	COG0477	Major facilitator Superfamily
IS_RS01680	COG0714	Associated with various cellular activities
IS_RS01725	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IS_RS01745	COG4772	TonB-dependent receptor
IS_RS01760	COG1012	belongs to the aldehyde dehydrogenase family
IS_RS01785	COG1304	FMN binding
IS_RS01800	COG1755	Isoprenylcysteine carboxyl methyltransferase
IS_RS01805	COG4585	Histidine kinase
IS_RS01810	COG2197	response regulator
IS_RS01830	COG3710	Transcriptional regulator
IS_RS01835	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IS_RS01845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS_RS01865	COG2963	transposase activity
IS_RS01875	COG3039	Transposase
IS_RS01910	COG0366	Alpha amylase catalytic
IS_RS01915	COG0366	Alpha amylase catalytic
IS_RS01920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IS_RS01935	COG2272	Belongs to the type-B carboxylesterase lipase family
IS_RS01940	COG2755	lipolytic protein G-D-S-L family
IS_RS01940	COG0657	acetylesterase activity
IS_RS01950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IS_RS01965	COG3507	Belongs to the glycosyl hydrolase 43 family
IS_RS01970	COG1609	Transcriptional regulator
IS_RS01975	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IS_RS01980	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS01990	COG2755	lipolytic protein G-D-S-L family
IS_RS02000	COG3186	Phenylalanine-4-hydroxylase
IS_RS02005	COG1522	sequence-specific DNA binding
IS_RS02015	COG1752	Esterase of the alpha-beta hydrolase superfamily
IS_RS02020	COG1473	amidohydrolase
IS_RS02030	COG1119	ATPase activity
IS_RS02045	COG1125	glycine betaine transport
IS_RS02060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IS_RS02095	COG0489	protein tyrosine kinase activity
IS_RS02100	COG2062	phosphohistidine phosphatase, SixA
IS_RS02110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS_RS02155	COG1968	undecaprenyl-diphosphatase activity
IS_RS02160	COG0174	glutamine synthetase
IS_RS02165	COG0347	Belongs to the P(II) protein family
IS_RS02170	COG0004	ammonium transporteR
IS_RS02175	COG3852	Histidine kinase
IS_RS02180	COG2204	response regulator
IS_RS02185	COG2032	superoxide dismutase activity
IS_RS02190	COG2032	superoxide dismutase activity
IS_RS02195	COG0346	lactoylglutathione lyase activity
IS_RS02205	COG0183	Belongs to the thiolase family
IS_RS02240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS_RS02245	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IS_RS02250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IS_RS02335	COG2963	transposase activity
IS_RS02380	COG0028	Belongs to the TPP enzyme family
IS_RS02385	COG4191	Histidine kinase
IS_RS02410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IS_RS02425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IS_RS02430	COG3177	Filamentation induced by cAMP protein fic
IS_RS02435	COG0596	Alpha beta hydrolase
IS_RS02440	COG0727	PFAM Uncharacterised protein family (UPF0153)
IS_RS02445	COG0318	PFAM AMP-dependent synthetase and ligase
IS_RS02450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS_RS02460	COG1181	Belongs to the D-alanine--D-alanine ligase family
IS_RS02475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IS_RS02485	COG0564	pseudouridine synthase activity
IS_RS02505	COG1446	asparaginase
IS_RS02510	COG0339	signal peptide processing
IS_RS02545	COG0475	glutathione-regulated potassium exporter activity
IS_RS02550	COG0583	DNA-binding transcription factor activity
IS_RS02555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IS_RS02560	COG2224	Isocitrate lyase
IS_RS02590	COG4770	biotin carboxylase activity
IS_RS02595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IS_RS02600	COG1960	acyl-CoA dehydrogenase activity
IS_RS02660	COG0523	cobalamin synthesis protein
IS_RS02675	COG0697	spore germination
IS_RS02685	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IS_RS02690	COG1846	Transcriptional regulator
IS_RS02695	COG1764	response to oxidative stress
IS_RS02715	COG2130	NADP-dependent
IS_RS02730	COG1187	pseudouridine synthase activity
IS_RS02740	COG1643	Atp-dependent helicase
IS_RS02750	COG4807	Protein conserved in bacteria
IS_RS02755	COG2351	hydroxyisourate hydrolase activity
IS_RS02760	COG2072	flavoprotein involved in K transport
IS_RS02780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IS_RS02795	COG0583	DNA-binding transcription factor activity
IS_RS02830	COG2252	PERMEase
IS_RS02850	COG0084	hydrolase, TatD family'
IS_RS02865	COG0583	DNA-binding transcription factor activity
IS_RS02870	COG2814	Major facilitator Superfamily
IS_RS02880	COG2267	carboxylic ester hydrolase activity
IS_RS02885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IS_RS02890	COG1902	pentaerythritol trinitrate reductase activity
IS_RS02910	COG0745	RESPONSE REGULATOR receiver
IS_RS02915	COG2205	protein histidine kinase activity
IS_RS02920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS_RS02945	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IS_RS02950	COG0583	DNA-binding transcription factor activity
IS_RS02990	COG0702	epimerase
IS_RS02995	COG1733	regulation of RNA biosynthetic process
IS_RS03020	COG2801	Transposase and inactivated derivatives
IS_RS03040	COG0129	dihydroxy-acid dehydratase activity
IS_RS03060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS_RS03115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IS_RS03120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IS_RS03145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IS_RS03150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IS_RS03160	COG3485	protocatechuate 3,4-dioxygenase
IS_RS03165	COG3485	protocatechuate 3,4-dioxygenase
IS_RS03175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IS_RS03180	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS_RS03190	COG1414	Transcriptional regulator
IS_RS03200	COG0657	acetylesterase activity
IS_RS03210	COG0445	tRNA wobble uridine modification
IS_RS03220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IS_RS03245	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS03250	COG2267	carboxylic ester hydrolase activity
IS_RS03260	COG0156	8-amino-7-oxononanoate synthase activity
IS_RS03265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IS_RS03270	COG1040	competence protein
IS_RS03275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IS_RS03380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IS_RS03440	COG2963	transposase activity
IS_RS03445	COG2801	Transposase and inactivated derivatives
IS_RS03470	COG3264	Mechanosensitive ion channel
IS_RS03470	COG1511	domain protein
IS_RS03475	COG1368	sulfuric ester hydrolase activity
IS_RS03480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IS_RS03485	COG2354	Protein conserved in bacteria
IS_RS03495	COG0297	glycogen (starch) synthase activity
IS_RS03500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IS_RS03505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IS_RS03530	COG0702	epimerase
IS_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS03570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS03585	COG0513	Belongs to the DEAD box helicase family
IS_RS03595	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS_RS03610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IS_RS03620	COG3483	tryptophan 2,3-dioxygenase activity
IS_RS03625	COG3104	oligopeptide transport
IS_RS03645	COG2852	Protein conserved in bacteria
IS_RS03650	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IS_RS03670	COG1320	monovalent cation:proton antiporter activity
IS_RS03675	COG2212	antiporter activity
IS_RS03680	COG1863	multisubunit Na H antiporter MnhE subunit
IS_RS03685	COG0651	ATP synthesis coupled electron transport
IS_RS03690	COG1006	Multisubunit Na H antiporter MnhC subunit
IS_RS03695	COG2111	Na H antiporter
IS_RS03695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IS_RS03715	COG3179	chitinase
IS_RS03735	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IS_RS03740	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IS_RS03750	COG0456	acetyltransferase
IS_RS03755	COG1597	lipid kinase activity
IS_RS03775	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IS_RS03810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IS_RS03815	COG0134	indole-3-glycerol-phosphate synthase activity
IS_RS03825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS_RS03830	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IS_RS03840	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IS_RS03850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IS_RS03865	COG1051	belongs to the nudix hydrolase family
IS_RS03905	COG0316	Belongs to the HesB IscA family
IS_RS03920	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IS_RS03945	COG2814	Major facilitator Superfamily
IS_RS03950	COG1289	transmembrane transporter activity
IS_RS03955	COG0151	Belongs to the GarS family
IS_RS03965	COG0138	bifunctional purine biosynthesis protein purh
IS_RS03970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IS_RS03975	COG2267	carboxylic ester hydrolase activity
IS_RS03980	COG2453	phosphatase
IS_RS03980	COG0671	phosphoesterase, PA-phosphatase related
IS_RS04005	COG4589	Belongs to the CDS family
IS_RS04010	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IS_RS04035	COG2264	protein methyltransferase activity
IS_RS04055	COG0439	Biotin carboxylase
IS_RS04065	COG0511	ligase activity, forming carbon-carbon bonds
IS_RS04070	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IS_RS04080	COG1324	tolerance protein
IS_RS04085	COG2356	endonuclease I
IS_RS04095	COG0459	protein refolding
IS_RS04110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS_RS04135	COG3386	PFAM SMP-30 Gluconolaconase
IS_RS04145	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IS_RS04150	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IS_RS04180	COG0778	Nitroreductase
IS_RS04185	COG2353	YceI-like domain
IS_RS04220	COG3052	prosthetic group binding
IS_RS04245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IS_RS04255	COG1802	Transcriptional regulator
IS_RS04260	COG0546	phosphoglycolate phosphatase activity
IS_RS04300	COG0464	growth
IS_RS04330	COG2963	transposase activity
IS_RS04345	COG3039	Transposase
IS_RS04370	COG2963	transposase activity
IS_RS04375	COG4221	oxidoreductase activity
IS_RS04415	COG4221	oxidoreductase activity
IS_RS04425	COG0435	Glutathione S-transferase
IS_RS04475	COG1959	2 iron, 2 sulfur cluster binding
IS_RS04500	COG0697	spore germination
IS_RS04515	COG1113	amino acid transport
IS_RS04525	COG0598	Magnesium transport protein CorA
IS_RS04535	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IS_RS04570	COG0840	transmembrane signaling receptor activity
IS_RS04575	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IS_RS04575	COG5297	Belongs to the glycosyl hydrolase family 6
IS_RS04580	COG0659	secondary active sulfate transmembrane transporter activity
IS_RS04595	COG2943	transferase activity, transferring hexosyl groups
IS_RS04605	COG3275	phosphorelay sensor kinase activity
IS_RS04615	COG0181	hydroxymethylbilane synthase activity
IS_RS04650	COG1505	serine-type exopeptidase activity
IS_RS04655	COG0436	Aminotransferase
IS_RS04665	COG2832	Protein of unknown function (DUF454)
IS_RS04675	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IS_RS04685	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IS_RS04690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IS_RS04695	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IS_RS04725	COG3300	MHYT domain
IS_RS04725	COG5001	Diguanylate cyclase
IS_RS04730	COG0308	aminopeptidase N
IS_RS04755	COG2801	Transposase and inactivated derivatives
IS_RS04790	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IS_RS04800	COG3284	Transcriptional regulator
IS_RS04805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS_RS04810	COG1077	Cell shape determining protein MreB Mrl
IS_RS04815	COG1792	Involved in formation and maintenance of cell shape
IS_RS04830	COG0772	Belongs to the SEDS family
IS_RS04840	COG2951	lytic endotransglycosylase activity
IS_RS04845	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS_RS04850	COG1686	Belongs to the peptidase S11 family
IS_RS04860	COG2921	Belongs to the UPF0250 family
IS_RS04865	COG0321	lipoyl(octanoyl) transferase activity
IS_RS04870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IS_RS04885	COG0583	DNA-binding transcription factor activity
IS_RS04895	COG1051	belongs to the nudix hydrolase family
IS_RS04895	COG1056	cytidyltransferase-related domain
IS_RS04930	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IS_RS04935	COG0673	inositol 2-dehydrogenase activity
IS_RS04940	COG2823	Periplasmic or secreted lipoprotein
IS_RS04945	COG4251	negative regulation of phosphorylation
IS_RS04950	COG0784	Response regulator, receiver
IS_RS04955	COG4191	Histidine kinase
IS_RS04960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IS_RS05015	COG1459	type II secretion system
IS_RS05035	COG4795	General secretion pathway protein
IS_RS05060	COG2188	Transcriptional regulator
IS_RS05070	COG1609	Transcriptional regulator
IS_RS05075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS_RS05080	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IS_RS05090	COG0617	tRNA 3'-terminal CCA addition
IS_RS05095	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IS_RS05100	COG1012	belongs to the aldehyde dehydrogenase family
IS_RS05105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS_RS05130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IS_RS05140	COG2205	protein histidine kinase activity
IS_RS05170	COG3791	Glutathione-dependent formaldehyde-activating
IS_RS05185	COG0488	(ABC) transporter
IS_RS05195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IS_RS05205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IS_RS05215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS_RS05215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS_RS05235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IS_RS05240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IS_RS05245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IS_RS05265	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IS_RS05270	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IS_RS05280	COG2205	protein histidine kinase activity
IS_RS05285	COG0745	RESPONSE REGULATOR receiver
IS_RS05295	COG0277	FAD linked oxidase domain protein
IS_RS05300	COG1988	membrane-bound metal-dependent
IS_RS05305	COG0792	nuclease activity
IS_RS05340	COG0275	rRNA processing
IS_RS05345	COG3116	cell division
IS_RS05360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IS_RS05365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IS_RS05370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IS_RS05380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IS_RS05385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IS_RS05390	COG1181	Belongs to the D-alanine--D-alanine ligase family
IS_RS05395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IS_RS05410	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IS_RS05420	COG0739	heme binding
IS_RS05425	COG0653	protein targeting
IS_RS05430	COG0494	nUDIX hydrolase
IS_RS05440	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IS_RS05450	COG0604	alcohol dehydrogenase
IS_RS05450	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS05450	COG3321	synthase
IS_RS05505	COG2226	methyltransferase
IS_RS05510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IS_RS05520	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IS_RS05560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IS_RS05570	COG4106	trans-aconitate 2-methyltransferase activity
IS_RS05575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS_RS05585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS_RS05590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS_RS05595	COG0667	Aldo Keto reductase
IS_RS05605	COG4771	TonB-dependent receptor
IS_RS05625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS_RS05630	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IS_RS05640	COG2175	clavaminate synthase activity
IS_RS05650	COG4181	ATPase activity
IS_RS05665	COG0642	Histidine kinase
IS_RS05675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IS_RS05695	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IS_RS05700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IS_RS05715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IS_RS05720	COG2967	ApaG domain
IS_RS05725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IS_RS05730	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IS_RS05735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS_RS05740	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IS_RS05745	COG0123	including yeast histone deacetylase and acetoin utilization protein
IS_RS05750	COG2096	Adenosyltransferase
IS_RS05760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS_RS05765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS_RS05795	COG3384	dioxygenase
IS_RS05800	COG0583	DNA-binding transcription factor activity
IS_RS05805	COG0318	PFAM AMP-dependent synthetase and ligase
IS_RS05815	COG1024	Enoyl-CoA hydratase
IS_RS05835	COG3386	PFAM SMP-30 Gluconolaconase
IS_RS05845	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IS_RS05870	COG0697	spore germination
IS_RS05880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IS_RS05905	COG2197	response regulator
IS_RS05915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IS_RS05925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IS_RS05930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS_RS05935	COG0583	DNA-binding transcription factor activity
IS_RS05940	COG3634	alkyl hydroperoxide reductase activity
IS_RS05950	COG2890	protein-(glutamine-N5) methyltransferase activity
IS_RS05970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IS_RS05970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IS_RS05985	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IS_RS06025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IS_RS06030	COG1404	Belongs to the peptidase S8 family
IS_RS06035	COG1404	Belongs to the peptidase S8 family
IS_RS06040	COG1404	Belongs to the peptidase S8 family
IS_RS06045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS_RS06070	COG1295	ribonuclease BN
IS_RS06075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS_RS06080	COG1254	Belongs to the acylphosphatase family
IS_RS06095	COG0521	Mo-molybdopterin cofactor biosynthetic process
IS_RS06105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IS_RS06110	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IS_RS06120	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IS_RS06125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IS_RS06135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IS_RS06140	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IS_RS06145	COG0193	aminoacyl-tRNA hydrolase activity
IS_RS06150	COG0012	GTP binding
IS_RS06170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IS_RS06185	COG0250	Participates in transcription elongation, termination and antitermination
IS_RS06190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IS_RS06195	COG0081	regulation of translation
IS_RS06200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IS_RS06205	COG0222	ribosome binding
IS_RS06210	COG0085	RNA polymerase activity
IS_RS06215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IS_RS06220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IS_RS06225	COG0049	tRNA binding
IS_RS06230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IS_RS06235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IS_RS06245	COG0051	transcription antitermination factor activity, RNA binding
IS_RS06250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IS_RS06255	COG0088	Forms part of the polypeptide exit tunnel
IS_RS06260	COG0089	rRNA binding
IS_RS06265	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IS_RS06270	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IS_RS06280	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IS_RS06285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IS_RS06290	COG0255	Belongs to the universal ribosomal protein uL29 family
IS_RS06295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IS_RS06310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IS_RS06315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IS_RS06320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IS_RS06325	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IS_RS06330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IS_RS06340	COG1841	ribosomal large subunit assembly
IS_RS06345	COG0200	Binds to the 23S rRNA
IS_RS06350	COG0201	protein transport
IS_RS06375	COG0203	ribosomal protein L17
IS_RS06380	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IS_RS06400	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IS_RS06410	COG0154	amidase activity
IS_RS06420	COG1217	gtp-binding protein TYPA
IS_RS06425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IS_RS06430	COG0039	L-malate dehydrogenase activity
IS_RS06435	COG0625	glutathione transferase activity
IS_RS06445	COG0446	pyridine nucleotide-disulphide oxidoreductase
IS_RS06445	COG1902	pentaerythritol trinitrate reductase activity
IS_RS06455	COG2885	chlorophyll binding
IS_RS06475	COG0156	8-amino-7-oxononanoate synthase activity
IS_RS06480	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IS_RS06485	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IS_RS06490	COG4208	sulfate ABC transporter
IS_RS06495	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IS_RS06505	COG1063	alcohol dehydrogenase
IS_RS06525	COG0406	alpha-ribazole phosphatase activity
IS_RS06530	COG0285	dihydrofolate synthase activity
IS_RS06550	COG2833	Protein of unknown function (DUF455)
IS_RS06555	COG3291	Pkd domain containing protein
IS_RS06565	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IS_RS06570	COG0671	phosphoesterase, PA-phosphatase related
IS_RS06575	COG0438	transferase activity, transferring glycosyl groups
IS_RS06585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IS_RS06600	COG4783	chaperone-mediated protein folding
IS_RS06615	COG0473	3-isopropylmalate dehydrogenase activity
IS_RS06645	COG3852	Histidine kinase
IS_RS06655	COG0544	peptidyl-prolyl cis-trans isomerase activity
IS_RS06665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IS_RS06695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS_RS06705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS_RS06715	COG0328	RNA-DNA hybrid ribonuclease activity
IS_RS06720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS_RS06725	COG0631	protein serine/threonine phosphatase activity
IS_RS06755	COG2963	transposase activity
IS_RS06780	COG0859	PFAM glycosyl transferase family 9
IS_RS06785	COG3642	lipopolysaccharide core region biosynthetic process
IS_RS06790	COG1234	tRNA 3'-trailer cleavage
IS_RS06795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IS_RS06805	COG0315	cyclic pyranopterin monophosphate synthase activity
IS_RS06810	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IS_RS06815	COG0314	molybdopterin synthase activity
IS_RS06840	COG2963	transposase activity
IS_RS06845	COG2801	Transposase and inactivated derivatives
IS_RS06870	COG2801	Transposase and inactivated derivatives
IS_RS06880	COG0322	excinuclease ABC activity
IS_RS06920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IS_RS06925	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IS_RS06930	COG0537	adenosine 5'-monophosphoramidase activity
IS_RS06950	COG0714	Associated with various cellular activities
IS_RS06960	COG0424	maF-like protein
IS_RS06965	COG2963	transposase activity
IS_RS06970	COG2801	Transposase and inactivated derivatives
IS_RS06975	COG0424	maF-like protein
IS_RS06985	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IS_RS06990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IS_RS07020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IS_RS07025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IS_RS07055	COG3829	transcription factor binding
IS_RS07080	COG2828	Protein conserved in bacteria
IS_RS07095	COG2373	Large extracellular alpha-helical protein
IS_RS07110	COG4953	penicillin-binding protein 1C
IS_RS07140	COG0330	HflC and HflK could
IS_RS07145	COG0330	HflC and HflK could
IS_RS07155	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IS_RS07160	COG0308	aminopeptidase N
IS_RS07170	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS07175	COG1309	transcriptional regulator
IS_RS07220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IS_RS07230	COG0732	type I restriction modification DNA specificity domain
IS_RS07235	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IS_RS07265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IS_RS07275	COG3387	PFAM Glycoside hydrolase 15-related
IS_RS07280	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS07285	COG3537	Alpha-1,2-mannosidase
IS_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS07305	COG0492	ferredoxin-NADP+ reductase activity
IS_RS07330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IS_RS07335	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IS_RS07340	COG2080	2 iron, 2 sulfur cluster binding
IS_RS07375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS_RS07395	COG0587	DNA-directed DNA polymerase activity
IS_RS07410	COG1297	OPT oligopeptide transporter protein
IS_RS07425	COG0823	Involved in the tonB-independent uptake of proteins
IS_RS07425	COG1506	peptidase
IS_RS07440	COG2207	Transcriptional regulator
IS_RS07440	COG1917	Cupin 2, conserved barrel domain protein
IS_RS07460	COG0753	catalase activity
IS_RS07465	COG0656	L-ascorbic acid biosynthetic process
IS_RS07470	COG2272	Belongs to the type-B carboxylesterase lipase family
IS_RS07475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IS_RS07475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IS_RS07500	COG2814	Major facilitator Superfamily
IS_RS07520	COG2194	sulfuric ester hydrolase activity
IS_RS07535	COG0745	RESPONSE REGULATOR receiver
IS_RS07540	COG0642	Histidine kinase
IS_RS07550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IS_RS07555	COG2894	cell division
IS_RS07560	COG0850	regulation of cytokinetic process
IS_RS07570	COG4585	Histidine kinase
IS_RS07575	COG2197	response regulator
IS_RS07595	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IS_RS07620	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IS_RS07635	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IS_RS07650	COG1595	DNA-templated transcription, initiation
IS_RS07665	COG1024	Enoyl-CoA hydratase
IS_RS07675	COG0824	Thioesterase
IS_RS07680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IS_RS07685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IS_RS07690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IS_RS07695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IS_RS07700	COG0268	Binds directly to 16S ribosomal RNA
IS_RS07710	COG0196	riboflavin kinase activity
IS_RS07715	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IS_RS07720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IS_RS07725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IS_RS07740	COG3039	Transposase
IS_RS07775	COG2963	transposase activity
IS_RS07815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IS_RS07820	COG1845	cytochrome c oxidase, subunit III
IS_RS07825	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IS_RS07840	COG3152	Membrane
IS_RS07850	COG2207	Transcriptional regulator
IS_RS07855	COG0326	Molecular chaperone. Has ATPase activity
IS_RS07865	COG1366	Belongs to the anti-sigma-factor antagonist family
IS_RS07870	COG1366	Belongs to the anti-sigma-factor antagonist family
IS_RS07875	COG2172	sigma factor antagonist activity
IS_RS07900	COG4771	TonB-dependent receptor
IS_RS07910	COG5507	3-demethylubiquinone-9 3-methyltransferase
IS_RS07915	COG2205	protein histidine kinase activity
IS_RS07925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IS_RS07930	COG3850	Histidine kinase
IS_RS07930	COG4999	Histidine kinase
IS_RS07930	COG3437	response regulator, receiver
IS_RS07930	COG2205	protein histidine kinase activity
IS_RS07935	COG4191	Histidine kinase
IS_RS07935	COG0784	Response regulator, receiver
IS_RS07960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS_RS07965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IS_RS07975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IS_RS07980	COG0228	four-way junction DNA binding
IS_RS07985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IS_RS07990	COG0336	Belongs to the RNA methyltransferase TrmD family
IS_RS07995	COG0335	large ribosomal subunit rRNA binding
IS_RS08000	COG0534	Mate efflux family protein
IS_RS08025	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IS_RS08035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IS_RS08050	COG2801	Transposase and inactivated derivatives
IS_RS08055	COG2963	transposase activity
IS_RS08070	COG3250	beta-galactosidase activity
IS_RS08075	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IS_RS08095	COG1960	acyl-CoA dehydrogenase activity
IS_RS08100	COG1024	Enoyl-CoA hydratase
IS_RS08120	COG1024	Enoyl-CoA hydratase
IS_RS08120	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS_RS08135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS_RS08140	COG0481	GTPase activity
IS_RS08155	COG0571	ribonuclease III activity
IS_RS08160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IS_RS08170	COG1381	Involved in DNA repair and RecF pathway recombination
IS_RS08185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IS_RS08190	COG2954	triphosphatase activity
IS_RS08195	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IS_RS08200	COG1233	COG1233 Phytoene dehydrogenase and related
IS_RS08205	COG3046	protein related to deoxyribodipyrimidine photolyase
IS_RS08210	COG1472	Belongs to the glycosyl hydrolase 3 family
IS_RS08215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IS_RS08220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IS_RS08225	COG1278	Cold shock
IS_RS08240	COG1201	RNA secondary structure unwinding
IS_RS08245	COG1793	dna ligase
IS_RS08255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IS_RS08255	COG1793	dna ligase
IS_RS08285	COG0183	Belongs to the thiolase family
IS_RS08305	COG1451	nucleotide metabolic process
IS_RS08310	COG5487	UPF0391 membrane protein
IS_RS08320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS_RS08340	COG1077	Cell shape determining protein MreB Mrl
IS_RS08355	COG2824	Alkylphosphonate utilization operon protein PhnA
IS_RS08360	COG1902	pentaerythritol trinitrate reductase activity
IS_RS08365	COG2814	Major facilitator Superfamily
IS_RS08400	COG0392	lysyltransferase activity
IS_RS08400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IS_RS08410	COG0251	oxidation-reduction process
IS_RS08415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS_RS08430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS_RS08455	COG1595	DNA-templated transcription, initiation
IS_RS08475	COG2878	Part of a membrane complex involved in electron transport
IS_RS08485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS_RS08485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS_RS08505	COG0346	lactoylglutathione lyase activity
IS_RS08520	COG0833	amino acid
IS_RS08525	COG2040	homocysteine
IS_RS08535	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IS_RS08555	COG1695	Transcriptional regulator
IS_RS08575	COG1981	membrane
IS_RS08590	COG0825	malonyl-CoA metabolic process
IS_RS08595	COG0587	DNA-directed DNA polymerase activity
IS_RS08605	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IS_RS08610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IS_RS08615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IS_RS08620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IS_RS08635	COG0750	zinc metalloprotease
IS_RS08640	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IS_RS08645	COG0575	Belongs to the CDS family
IS_RS08650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IS_RS08655	COG0233	cytoplasmic translational termination
IS_RS08660	COG0528	UMP kinase activity
IS_RS08670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IS_RS08675	COG0052	Belongs to the universal ribosomal protein uS2 family
IS_RS08715	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IS_RS08725	COG1393	Belongs to the ArsC family
IS_RS08730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IS_RS08735	COG0367	asparagine synthase
IS_RS08760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IS_RS08785	COG1566	PFAM secretion protein HlyD family protein
IS_RS08790	COG2814	Major facilitator Superfamily
IS_RS08850	COG0339	signal peptide processing
IS_RS08855	COG0386	Belongs to the glutathione peroxidase family
IS_RS08915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IS_RS08920	COG0084	hydrolase, TatD family'
IS_RS08935	COG1960	acyl-CoA dehydrogenase activity
IS_RS08950	COG0367	asparagine synthase
IS_RS08960	COG0305	Participates in initiation and elongation during chromosome replication
IS_RS08965	COG0415	Belongs to the DNA photolyase family
IS_RS08975	COG0583	DNA-binding transcription factor activity
IS_RS09020	COG3706	GGDEF domain
IS_RS09035	COG2963	transposase activity
IS_RS09055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IS_RS09070	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS_RS09080	COG0497	DNA recombination
IS_RS09085	COG1420	regulation of RNA biosynthetic process
IS_RS09090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IS_RS09095	COG0443	Heat shock 70 kDa protein
IS_RS09100	COG0484	heat shock protein binding
IS_RS09105	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IS_RS09135	COG0583	DNA-binding transcription factor activity
IS_RS09140	COG1132	(ABC) transporter
IS_RS09175	COG2850	peptidyl-arginine hydroxylation
IS_RS09195	COG1253	flavin adenine dinucleotide binding
IS_RS09225	COG1131	(ABC) transporter
IS_RS09230	COG1725	Transcriptional regulator
IS_RS09235	COG0386	Belongs to the glutathione peroxidase family
IS_RS09250	COG2900	Belongs to the SlyX family
IS_RS09275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS_RS09285	COG0646	methionine synthase
IS_RS09285	COG1410	methionine synthase
IS_RS09290	COG1410	methionine synthase
IS_RS09290	COG0646	methionine synthase
IS_RS09295	COG2226	methyltransferase
IS_RS09300	COG1960	acyl-CoA dehydrogenase activity
IS_RS09320	COG0557	exoribonuclease II activity
IS_RS09335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS_RS09350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS_RS09360	COG0704	Plays a role in the regulation of phosphate uptake
IS_RS09365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IS_RS09370	COG0581	inorganic phosphate transmembrane transporter activity
IS_RS09375	COG0573	inorganic phosphate transmembrane transporter activity
IS_RS09380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IS_RS09405	COG0659	secondary active sulfate transmembrane transporter activity
IS_RS09410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IS_RS09420	COG1024	Enoyl-CoA hydratase
IS_RS09430	COG0494	nUDIX hydrolase
IS_RS09465	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IS_RS09475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IS_RS09475	COG0116	Belongs to the methyltransferase superfamily
IS_RS09480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IS_RS09500	COG2925	Exonuclease
IS_RS09505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS_RS09510	COG3844	kynureninase activity
IS_RS09520	COG0662	Cupin 2, conserved barrel domain protein
IS_RS09525	COG0288	reversible hydration of carbon dioxide
IS_RS09580	COG2808	Putative FMN-binding domain
IS_RS09600	COG0017	Asparaginyl-tRNA synthetase
IS_RS09605	COG0316	Belongs to the HesB IscA family
IS_RS09610	COG0360	Binds together with S18 to 16S ribosomal RNA
IS_RS09615	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IS_RS09620	COG0359	binds to the 23S rRNA
IS_RS09630	COG3115	cell septum assembly
IS_RS09640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IS_RS09645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IS_RS09650	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IS_RS09660	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IS_RS09670	COG4993	Dehydrogenase
IS_RS09680	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IS_RS09690	COG2986	histidine ammonia-lyase
IS_RS09695	COG1228	amidohydrolase
IS_RS09735	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IS_RS09740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IS_RS09745	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IS_RS09750	COG0077	Prephenate dehydratase
IS_RS09750	COG1605	Chorismate mutase
IS_RS09755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IS_RS09770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IS_RS09775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IS_RS09780	COG0583	DNA-binding transcription factor activity
IS_RS09800	COG2801	Transposase and inactivated derivatives
IS_RS09815	COG0840	transmembrane signaling receptor activity
IS_RS09850	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IS_RS09855	COG0784	Response regulator, receiver
IS_RS09855	COG4191	Histidine kinase
IS_RS09870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS_RS09880	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IS_RS09890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS_RS09905	COG1595	DNA-templated transcription, initiation
IS_RS09945	COG2244	polysaccharide biosynthetic process
IS_RS09975	COG2264	protein methyltransferase activity
IS_RS09985	COG0438	transferase activity, transferring glycosyl groups
IS_RS10000	COG1136	(ABC) transporter
IS_RS10005	COG1132	(ABC) transporter
IS_RS10015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS_RS10030	COG1253	flavin adenine dinucleotide binding
IS_RS10040	COG0306	phosphate transporter
IS_RS10065	COG0504	CTP synthase activity
IS_RS10070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IS_RS10080	COG0148	phosphopyruvate hydratase activity
IS_RS10085	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IS_RS10090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IS_RS10095	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IS_RS10100	COG0585	pseudouridine synthase activity
IS_RS10105	COG2840	Smr protein MutS2
IS_RS10110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IS_RS10115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IS_RS10120	COG1238	metal cluster binding
IS_RS10135	COG1534	Rna-binding protein
IS_RS10140	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IS_RS10150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IS_RS10155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IS_RS10165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IS_RS10170	COG1546	Belongs to the CinA family
IS_RS10180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS_RS10185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IS_RS10190	COG2137	regulation of response to DNA damage stimulus
IS_RS10195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IS_RS10200	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IS_RS10215	COG1741	Belongs to the pirin family
IS_RS10225	COG0583	DNA-binding transcription factor activity
IS_RS10250	COG0351	phosphomethylpyrimidine kinase
IS_RS10265	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IS_RS10270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IS_RS10285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IS_RS10295	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IS_RS10300	COG3734	2-keto-3-deoxy-galactonokinase
IS_RS10310	COG4948	Mandelate Racemase Muconate Lactonizing
IS_RS10315	COG0800	Aldolase
IS_RS10355	COG1501	Belongs to the glycosyl hydrolase 31 family
IS_RS10365	COG1070	Carbohydrate kinase
IS_RS10370	COG2115	Belongs to the xylose isomerase family
IS_RS10375	COG0477	Major facilitator Superfamily
IS_RS10390	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS_RS10395	COG1469	GTP cyclohydrolase I activity
IS_RS10415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IS_RS10420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IS_RS10425	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IS_RS10430	COG0166	Belongs to the GPI family
IS_RS10450	COG1472	Belongs to the glycosyl hydrolase 3 family
IS_RS10460	COG2203	Gaf domain
IS_RS10460	COG5001	Diguanylate cyclase
IS_RS10460	COG3706	GGDEF domain
IS_RS10460	COG4251	negative regulation of phosphorylation
IS_RS10465	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IS_RS10470	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IS_RS10480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IS_RS10485	COG0671	phosphoesterase, PA-phosphatase related
IS_RS10495	COG1794	racemase activity, acting on amino acids and derivatives
IS_RS10500	COG0697	spore germination
IS_RS10505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IS_RS10510	COG0167	dihydroorotate dehydrogenase activity
IS_RS10525	COG1012	belongs to the aldehyde dehydrogenase family
IS_RS10540	COG2963	transposase activity
IS_RS10555	COG2801	Transposase and inactivated derivatives
IS_RS10565	COG2801	Transposase and inactivated derivatives
IS_RS10570	COG2963	transposase activity
IS_RS10585	COG2801	Transposase and inactivated derivatives
IS_RS10590	COG2801	Transposase and inactivated derivatives
IS_RS10595	COG2963	transposase activity
IS_RS10635	COG3210	domain, Protein
IS_RS10645	COG2963	transposase activity
IS_RS10655	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IS_RS10660	COG0460	homoserine dehydrogenase
IS_RS10660	COG0527	aspartate kinase activity
IS_RS10685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS_RS10690	COG0124	histidyl-tRNA synthetase
IS_RS10700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IS_RS10705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IS_RS10710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IS_RS10715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IS_RS10715	COG0131	Imidazoleglycerol-phosphate dehydratase
IS_RS10720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IS_RS10725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IS_RS10730	COG0107	imidazoleglycerol-phosphate synthase activity
IS_RS10735	COG0140	phosphoribosyl-ATP diphosphatase activity
IS_RS10735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IS_RS10750	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IS_RS10755	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IS_RS10760	COG0235	Class ii aldolase
IS_RS10765	COG0531	amino acid
IS_RS10770	COG0531	amino acid
IS_RS10780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS_RS10785	COG0277	FAD linked oxidase domain protein
IS_RS10805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IS_RS10850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS_RS10855	COG2258	MOSC domain
IS_RS10860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IS_RS10865	COG0505	Belongs to the CarA family
IS_RS10875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IS_RS10880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS_RS10890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IS_RS10900	COG3279	Response regulator of the LytR AlgR family
IS_RS10905	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IS_RS10910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IS_RS10920	COG2198	Histidine kinase
IS_RS10920	COG2205	protein histidine kinase activity
IS_RS10920	COG0784	Response regulator, receiver
IS_RS10925	COG2198	Histidine kinase
IS_RS10925	COG0784	Response regulator, receiver
IS_RS10925	COG2205	protein histidine kinase activity
IS_RS10930	COG1024	Enoyl-CoA hydratase
IS_RS10935	COG0318	PFAM AMP-dependent synthetase and ligase
IS_RS10970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IS_RS10980	COG2201	protein-glutamate methylesterase activity
IS_RS10985	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IS_RS10995	COG0840	transmembrane signaling receptor activity
IS_RS11005	COG0835	chemotaxis
IS_RS11015	COG0840	transmembrane signaling receptor activity
IS_RS11020	COG0840	transmembrane signaling receptor activity
IS_RS11025	COG0840	transmembrane signaling receptor activity
IS_RS11030	COG0840	transmembrane signaling receptor activity
IS_RS11035	COG0840	transmembrane signaling receptor activity
IS_RS11045	COG0840	transmembrane signaling receptor activity
IS_RS11050	COG0840	transmembrane signaling receptor activity
IS_RS11055	COG0840	transmembrane signaling receptor activity
IS_RS11070	COG0840	transmembrane signaling receptor activity
IS_RS11085	COG0840	transmembrane signaling receptor activity
IS_RS11090	COG0840	transmembrane signaling receptor activity
IS_RS11100	COG0745	RESPONSE REGULATOR receiver
IS_RS11110	COG0835	chemotaxis
IS_RS11120	COG1360	Flagellar Motor Protein
IS_RS11125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IS_RS11155	COG2963	transposase activity
IS_RS11185	COG0643	Histidine kinase
IS_RS11185	COG0784	Response regulator, receiver
IS_RS11185	COG2198	Histidine kinase
IS_RS11240	COG1684	flagellar biosynthetic protein fliR
IS_RS11255	COG3190	flagellar
IS_RS11305	COG1677	Flagellar hook-basal body complex protein FliE
IS_RS11315	COG0275	rRNA processing
IS_RS11320	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IS_RS11355	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS11360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IS_RS11380	COG2201	protein-glutamate methylesterase activity
IS_RS11410	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IS_RS11415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IS_RS11420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IS_RS11430	COG1705	Flagellar rod assembly protein muramidase FlgJ
IS_RS11430	COG3951	Flagellar rod assembly protein muramidase FlgJ
IS_RS11435	COG1706	bacterial-type flagellum-dependent cell motility
IS_RS11440	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IS_RS11455	COG4787	bacterial-type flagellum-dependent cell motility
IS_RS11465	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IS_RS11470	COG1558	bacterial-type flagellum-dependent cell motility
IS_RS11480	COG0835	chemotaxis
IS_RS11480	COG0784	Response regulator, receiver
IS_RS11500	COG5002	protein histidine kinase activity
IS_RS11530	COG2915	High frequency lysogenization protein hflD homolog
IS_RS11535	COG0482	sulfurtransferase activity
IS_RS11550	COG0542	response to heat
IS_RS11560	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IS_RS11575	COG0492	ferredoxin-NADP+ reductase activity
IS_RS11580	COG1674	ftsk spoiiie
IS_RS11590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IS_RS11600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IS_RS11605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IS_RS11610	COG0183	Belongs to the thiolase family
IS_RS11615	COG1024	Enoyl-CoA hydratase
IS_RS11615	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS_RS11630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IS_RS11640	COG1426	Protein conserved in bacteria
IS_RS11650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS_RS11655	COG1160	GTP binding
IS_RS11660	COG0303	'Molybdopterin
IS_RS11665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IS_RS11705	COG0708	Exodeoxyribonuclease III
IS_RS11715	COG0303	'Molybdopterin
IS_RS11720	COG0746	molybdenum cofactor guanylyltransferase activity
IS_RS11745	COG1648	precorrin-2 dehydrogenase activity
IS_RS11745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IS_RS11755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS_RS11760	COG2223	nitrite transmembrane transporter activity
IS_RS11765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS_RS11775	COG0243	molybdopterin cofactor binding
IS_RS11790	COG3685	Protein conserved in bacteria
IS_RS11810	COG5001	Diguanylate cyclase
IS_RS11820	COG4566	intracellular signal transduction
IS_RS11840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS_RS11860	COG3279	Response regulator of the LytR AlgR family
IS_RS12005	COG0631	protein serine/threonine phosphatase activity
IS_RS12010	COG0515	serine threonine protein kinase
IS_RS12035	COG1858	cytochrome C peroxidase
IS_RS12050	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IS_RS12065	COG4585	Histidine kinase
IS_RS12070	COG2197	response regulator
IS_RS12090	COG2801	Transposase and inactivated derivatives
IS_RS12130	COG1002	Type II restriction enzyme, methylase subunits
IS_RS12135	COG1061	Type III restriction enzyme res subunit
IS_RS12140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IS_RS12145	COG1196	nuclear chromosome segregation
IS_RS12165	COG2818	Glycosylase
IS_RS12170	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS12180	COG0583	DNA-binding transcription factor activity
IS_RS12185	COG0667	Aldo Keto reductase
IS_RS12190	COG3002	Belongs to the UPF0753 family
IS_RS12195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IS_RS12200	COG0583	DNA-binding transcription factor activity
IS_RS12210	COG0633	Ferredoxin
IS_RS12230	COG0583	DNA-binding transcription factor activity
IS_RS12250	COG2197	response regulator
IS_RS12255	COG4585	Histidine kinase
IS_RS12265	COG1335	isochorismatase
IS_RS12280	COG2814	Major facilitator Superfamily
IS_RS12300	COG1914	H( )-stimulated, divalent metal cation uptake system
IS_RS12315	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IS_RS12320	COG0668	transmembrane transport
IS_RS12330	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IS_RS12345	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS12350	COG1183	phosphatidylcholine synthase activity
IS_RS12360	COG3243	poly(R)-hydroxyalkanoic acid synthase
IS_RS12375	COG0723	plastoquinol--plastocyanin reductase activity
IS_RS12375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS_RS12385	COG2183	response to ionizing radiation
IS_RS12390	COG0784	Response regulator, receiver
IS_RS12390	COG2205	protein histidine kinase activity
IS_RS12405	COG0582	viral genome integration into host DNA
IS_RS12480	COG0800	Aldolase
IS_RS12485	COG0129	dihydroxy-acid dehydratase activity
IS_RS12490	COG0363	glucosamine-6-phosphate deaminase activity
IS_RS12495	COG0837	glucose binding
IS_RS12500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IS_RS12510	COG0354	folic acid binding
IS_RS12520	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IS_RS12535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS_RS12540	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IS_RS12550	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS_RS12555	COG1136	(ABC) transporter
IS_RS12570	COG0811	peptide transport
IS_RS12580	COG1132	(ABC) transporter
IS_RS12585	COG1663	tetraacyldisaccharide 4'-kinase activity
IS_RS12590	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IS_RS12595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IS_RS12605	COG0322	excinuclease ABC activity
IS_RS12610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IS_RS12620	COG0582	viral genome integration into host DNA
IS_RS12625	COG2801	Transposase and inactivated derivatives
IS_RS12670	COG2826	transposase and inactivated derivatives, IS30 family
IS_RS12680	COG4644	lycopene metabolic process
IS_RS12735	COG0270	DNA (cytosine-5-)-methyltransferase activity
IS_RS12745	COG0629	single-stranded DNA binding
IS_RS12785	COG2801	Transposase and inactivated derivatives
IS_RS12805	COG0582	viral genome integration into host DNA
IS_RS12815	COG1396	sequence-specific DNA binding
IS_RS12820	COG0583	DNA-binding transcription factor activity
IS_RS12850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS_RS12855	COG4232	protein-disulfide reductase activity
IS_RS12860	COG0745	RESPONSE REGULATOR receiver
IS_RS12870	COG0492	ferredoxin-NADP+ reductase activity
IS_RS12895	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IS_RS12905	COG1275	C4-dicarboxylate transporter malic acid transport protein
IS_RS12935	COG1573	uracil-dna glycosylase
IS_RS12950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IS_RS12975	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IS_RS12985	COG2814	Major facilitator Superfamily
IS_RS12990	COG0789	Transcriptional regulator
IS_RS13000	COG0640	Transcriptional regulator
IS_RS13005	COG1230	cation diffusion facilitator family transporter
IS_RS13075	COG2801	Transposase and inactivated derivatives
IS_RS13090	COG0583	DNA-binding transcription factor activity
IS_RS13145	COG2003	Belongs to the UPF0758 family
IS_RS13345	COG0270	DNA (cytosine-5-)-methyltransferase activity
IS_RS13350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IS_RS13355	COG0629	single-stranded DNA binding
IS_RS13410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IS_RS13430	COG1054	Belongs to the UPF0176 family
IS_RS13440	COG1530	ribonuclease E activity
IS_RS13450	COG3064	Membrane
IS_RS13455	COG0428	transporter
IS_RS13465	COG2154	pterin-4-alpha-carbinolamine dehydratase
IS_RS13470	COG0316	Belongs to the HesB IscA family
IS_RS13470	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IS_RS13485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS_RS13490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS_RS13520	COG4644	lycopene metabolic process
IS_RS13525	COG2951	lytic endotransglycosylase activity
IS_RS13530	COG0730	response to heat
IS_RS13555	COG0640	Transcriptional regulator
IS_RS13695	COG1484	DNA-dependent DNA replication
IS_RS13705	COG2801	Transposase and inactivated derivatives
IS_RS13735	COG0582	viral genome integration into host DNA
IS_RS13740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IS_RS13740	COG0519	Catalyzes the synthesis of GMP from XMP
IS_RS13750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IS_RS13760	COG0475	glutathione-regulated potassium exporter activity
IS_RS13760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IS_RS13765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IS_RS13775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IS_RS13780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IS_RS13790	COG0776	regulation of translation
IS_RS13795	COG0539	negative regulation of cytoplasmic translation
IS_RS13800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IS_RS13815	COG2957	Belongs to the agmatine deiminase family
IS_RS13820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS_RS13845	COG0395	ABC-type sugar transport system, permease component
IS_RS13850	COG1175	transmembrane transport
IS_RS13880	COG2350	Protein conserved in bacteria
IS_RS13885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IS_RS13890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IS_RS13895	COG1187	pseudouridine synthase activity
IS_RS13915	COG0436	Aminotransferase
IS_RS13920	COG4133	protoheme IX ABC transporter activity
IS_RS13940	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IS_RS13945	COG1138	Cytochrome C-type biogenesis protein
IS_RS13965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IS_RS13970	COG1278	Cold shock
IS_RS13975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IS_RS13980	COG4988	ABC transporter
IS_RS13990	COG1294	oxidase, subunit
IS_RS14020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IS_RS14025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IS_RS14035	COG0165	Argininosuccinate lyase
IS_RS14040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IS_RS14050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IS_RS14055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IS_RS14065	COG0137	argininosuccinate synthase activity
IS_RS14070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IS_RS14080	COG0215	cysteine-tRNA ligase activity
IS_RS14085	COG2166	iron-sulfur cluster assembly
IS_RS14105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IS_RS14110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IS_RS14130	COG4303	Ethanolamine ammonia lyase large subunit
IS_RS14175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IS_RS14180	COG0402	S-adenosylhomocysteine deaminase activity
IS_RS14190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IS_RS14195	COG1509	lysine 2,3-aminomutase activity
IS_RS14200	COG3300	MHYT domain
IS_RS14200	COG5001	Diguanylate cyclase
IS_RS14215	COG0483	inositol monophosphate 1-phosphatase activity
IS_RS14220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IS_RS14235	COG0488	(ABC) transporter
IS_RS14240	COG0513	Belongs to the DEAD box helicase family
IS_RS14245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IS_RS14250	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IS_RS14260	COG0625	glutathione transferase activity
IS_RS14270	COG4681	YaeQ
IS_RS14275	COG2081	HI0933 family
IS_RS14285	COG0501	Belongs to the peptidase M48B family
IS_RS14290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IS_RS14295	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS14315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IS_RS14320	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS_RS14325	COG0802	atpase or kinase
IS_RS14330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IS_RS14330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IS_RS14335	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IS_RS14340	COG1570	exodeoxyribonuclease VII activity
IS_RS14350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IS_RS14380	COG0582	viral genome integration into host DNA
IS_RS14390	COG2963	transposase activity
IS_RS14425	COG0835	chemotaxis
IS_RS14430	COG0840	transmembrane signaling receptor activity
IS_RS14435	COG2094	Belongs to the DNA glycosylase MPG family
IS_RS14440	COG1201	RNA secondary structure unwinding
IS_RS14455	COG2969	positive regulation of protein catabolic process
IS_RS14460	COG0625	glutathione transferase activity
IS_RS14465	COG2857	Cytochrome c1
IS_RS14470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IS_RS14475	COG0723	plastoquinol--plastocyanin reductase activity
IS_RS14480	COG0741	lytic transglycosylase activity
IS_RS14495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IS_RS14500	COG1702	phosphate starvation-inducible protein PhoH
IS_RS14510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IS_RS14520	COG4535	Mg2 and Co2 transporter CorC
IS_RS14535	COG1012	belongs to the aldehyde dehydrogenase family
IS_RS14545	COG1177	transmembrane transport
IS_RS14550	COG1176	ABC-type spermidine putrescine transport system, permease component I
IS_RS14575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IS_RS14590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IS_RS14595	COG0174	glutamine synthetase
IS_RS14600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS_RS14610	COG2703	oxygen carrier activity
IS_RS14615	COG0477	Major facilitator Superfamily
IS_RS14625	COG0243	molybdopterin cofactor binding
IS_RS14630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IS_RS14635	COG2223	nitrite transmembrane transporter activity
IS_RS14640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IS_RS14650	COG2733	membrane
IS_RS14655	COG2205	protein histidine kinase activity
IS_RS14655	COG5002	protein histidine kinase activity
IS_RS14655	COG0784	Response regulator, receiver
IS_RS14665	COG0477	Major facilitator Superfamily
IS_RS14670	COG2902	Dehydrogenase
IS_RS14680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS_RS14685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS_RS14690	COG1609	Transcriptional regulator
IS_RS14695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IS_RS14695	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS_RS14700	COG1105	Belongs to the carbohydrate kinase PfkB family
IS_RS14705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS_RS14705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS_RS14745	COG2801	Transposase and inactivated derivatives
IS_RS14755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS_RS14765	COG1862	Preprotein translocase
IS_RS14770	COG0343	queuine tRNA-ribosyltransferase activity
IS_RS14775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IS_RS14815	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IS_RS14820	COG3291	Pkd domain containing protein
IS_RS14830	COG0405	Gamma-glutamyltransferase
IS_RS14835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS_RS14850	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IS_RS14855	COG0742	ribosomal rna small subunit methyltransferase
IS_RS14860	COG0326	Molecular chaperone. Has ATPase activity
IS_RS14895	COG2963	transposase activity
IS_RS14970	COG0531	amino acid
IS_RS14985	COG0006	proline dipeptidase activity
IS_RS14995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IS_RS15010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS_RS15015	COG3938	Belongs to the proline racemase family
IS_RS15025	COG0552	protein localization to endoplasmic reticulum
IS_RS15030	COG1194	a g-specific adenine glycosylase
IS_RS15035	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IS_RS15040	COG0784	Response regulator, receiver
IS_RS15040	COG4191	Histidine kinase
IS_RS15070	COG3040	lipid binding
IS_RS15080	COG1960	acyl-CoA dehydrogenase activity
IS_RS15090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IS_RS15110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS_RS15115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS_RS15120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IS_RS15135	COG2963	transposase activity
IS_RS15160	COG0438	transferase activity, transferring glycosyl groups
IS_RS15170	COG0438	transferase activity, transferring glycosyl groups
IS_RS15175	COG0438	transferase activity, transferring glycosyl groups
IS_RS15225	COG0072	phenylalanine-tRNA ligase activity
IS_RS15225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS_RS15230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IS_RS15245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IS_RS15250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IS_RS15275	COG1082	Xylose isomerase domain protein TIM barrel
IS_RS15290	COG0366	Alpha amylase catalytic
IS_RS15300	COG2963	transposase activity
IS_RS15320	COG3505	Type IV secretory pathway VirD4
IS_RS15340	COG0556	nucleotide-excision repair
IS_RS15370	COG2963	transposase activity
IS_RS15390	COG1611	Belongs to the LOG family
IS_RS15400	COG2095	MarC family integral membrane protein
IS_RS15410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IS_RS15445	COG1185	polyribonucleotide nucleotidyltransferase activity
IS_RS15450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IS_RS15455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IS_RS15460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IS_RS15465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IS_RS15470	COG0195	Participates in both transcription termination and antitermination
IS_RS15475	COG0779	Required for maturation of 30S ribosomal subunits
IS_RS15485	COG1007	ATP synthesis coupled electron transport
IS_RS15510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS_RS15515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IS_RS15520	COG1034	ATP synthesis coupled electron transport
IS_RS15525	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IS_RS15530	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IS_RS15535	COG0649	NAD binding
IS_RS15540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS_RS15545	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS_RS15550	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS_RS15565	COG0149	triose-phosphate isomerase activity
IS_RS15570	COG4221	oxidoreductase activity
IS_RS15610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IS_RS15615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IS_RS15620	COG0159	tryptophan synthase activity
IS_RS15630	COG2801	Transposase and inactivated derivatives
IS_RS15645	COG0133	tryptophan synthase activity
IS_RS15655	COG0135	phosphoribosylanthranilate isomerase activity
IS_RS15660	COG0101	tRNA pseudouridine synthase activity
IS_RS15680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS_RS15685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IS_RS15690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IS_RS15695	COG2890	protein-(glutamine-N5) methyltransferase activity
IS_RS15705	COG0688	phosphatidylethanolamine metabolic process
IS_RS15715	COG0433	COG0433 Predicted ATPase
IS_RS15720	COG0494	nUDIX hydrolase
IS_RS15735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS_RS15740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IS_RS15765	COG0717	Belongs to the dCTP deaminase family
IS_RS15770	COG0489	protein tyrosine kinase activity
IS_RS15790	COG3590	peptidase
IS_RS15795	COG3590	peptidase
IS_RS15815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS_RS15820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS_RS15825	COG2311	Membrane
IS_RS15830	COG1047	Peptidyl-prolyl cis-trans
IS_RS15835	COG0791	NLP P60 protein
IS_RS15840	COG0791	NLP P60 protein
IS_RS15855	COG1301	dicarboxylic acid transport
IS_RS15860	COG1785	Belongs to the alkaline phosphatase family
IS_RS15865	COG0037	tRNA processing
IS_RS15870	COG1722	exodeoxyribonuclease VII activity
IS_RS15875	COG0142	geranyltranstransferase activity
IS_RS15880	COG4104	PAAR repeat-containing protein
IS_RS15890	COG0312	modulator of DNA gyrase
IS_RS15895	COG3028	Belongs to the UPF0307 family
IS_RS15900	COG0312	modulator of DNA gyrase
IS_RS15920	COG0424	maF-like protein
IS_RS15925	COG2968	Membrane
IS_RS15935	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IS_RS15950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IS_RS15965	COG0495	leucyl-tRNA aminoacylation
IS_RS15975	COG3118	belongs to the thioredoxin family
IS_RS16005	COG2155	Conserved Protein
IS_RS16060	COG1132	(ABC) transporter
IS_RS16085	COG1538	Outer membrane efflux protein
IS_RS16090	COG0745	RESPONSE REGULATOR receiver
IS_RS16100	COG0475	glutathione-regulated potassium exporter activity
IS_RS16110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IS_RS16135	COG1187	pseudouridine synthase activity
IS_RS16140	COG5002	protein histidine kinase activity
IS_RS16140	COG5001	Diguanylate cyclase
IS_RS16240	COG0667	Aldo Keto reductase
IS_RS16245	COG2814	Major facilitator Superfamily
IS_RS16250	COG0583	DNA-binding transcription factor activity
IS_RS16260	COG2207	Transcriptional regulator
IS_RS16275	COG1309	transcriptional regulator
IS_RS16300	COG0735	belongs to the Fur family
IS_RS16305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IS_RS16330	COG4452	Inner membrane protein CreD
IS_RS16345	COG2205	protein histidine kinase activity
IS_RS16350	COG0745	RESPONSE REGULATOR receiver
IS_RS16355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IS_RS16365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IS_RS16375	COG0643	Histidine kinase
IS_RS16375	COG2198	Histidine kinase
IS_RS16380	COG0840	transmembrane signaling receptor activity
IS_RS16385	COG0835	chemotaxis
IS_RS16390	COG2199	diguanylate cyclase activity
IS_RS16390	COG2200	EAL domain
IS_RS16390	COG2202	Pas domain
IS_RS16395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IS_RS16400	COG2201	protein-glutamate methylesterase activity
IS_RS16405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS_RS16410	COG3590	peptidase
IS_RS16420	COG0588	phosphoglycerate mutase activity
IS_RS16425	COG1515	deoxyribonuclease V activity
IS_RS16435	COG1741	Belongs to the pirin family
IS_RS16450	COG1741	Belongs to the pirin family
IS_RS16455	COG1966	Carbon starvation protein
IS_RS16460	COG2879	small protein
IS_RS16505	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IS_RS16510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IS_RS16515	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IS_RS16520	COG2080	2 iron, 2 sulfur cluster binding
IS_RS16525	COG3321	synthase
IS_RS16525	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS16525	COG0604	alcohol dehydrogenase
IS_RS16530	COG4251	negative regulation of phosphorylation
IS_RS16530	COG5001	Diguanylate cyclase
IS_RS16530	COG3706	GGDEF domain
IS_RS16530	COG2203	Gaf domain
IS_RS16535	COG0629	single-stranded DNA binding
IS_RS16540	COG0142	geranyltranstransferase activity
IS_RS16550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IS_RS16565	COG0527	aspartate kinase activity
IS_RS16570	COG0384	phenazine biosynthesis protein PhzF
IS_RS16575	COG0384	phenazine biosynthesis protein PhzF
IS_RS16585	COG1764	response to oxidative stress
IS_RS16590	COG0540	Belongs to the ATCase OTCase family
IS_RS16595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IS_RS16600	COG1678	Uncharacterized ACR, COG1678
IS_RS16605	COG0519	Catalyzes the synthesis of GMP from XMP
IS_RS16630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IS_RS16645	COG0739	heme binding
IS_RS16665	COG0693	protein deglycase activity
IS_RS16675	COG1959	2 iron, 2 sulfur cluster binding
IS_RS16680	COG0719	Fe-S assembly protein
IS_RS16685	COG0396	ATPase activity
IS_RS16690	COG0719	Fe-S assembly protein
IS_RS16695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IS_RS16705	COG2146	nitrite reductase [NAD(P)H] activity
IS_RS16710	COG4774	siderophore transport
IS_RS16715	COG3128	pkhd-type hydroxylase
IS_RS16740	COG1477	protein flavinylation
IS_RS16745	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IS_RS16760	COG1555	photosystem II stabilization
IS_RS16780	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IS_RS16790	COG0628	permease
IS_RS16800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IS_RS16810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IS_RS16830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IS_RS16835	COG0271	Belongs to the BolA IbaG family
IS_RS16845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IS_RS16855	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IS_RS16860	COG1137	ATPase activity
IS_RS16875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS_RS16880	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IS_RS16885	COG1660	Displays ATPase and GTPase activities
IS_RS16895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS_RS16900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IS_RS16905	COG2239	Acts as a magnesium transporter
IS_RS16915	COG1294	oxidase, subunit
IS_RS16920	COG1271	oxidase subunit
IS_RS16930	COG1113	amino acid transport
IS_RS16950	COG2197	response regulator
IS_RS16955	COG0531	amino acid
IS_RS17025	COG2814	Major facilitator Superfamily
IS_RS17030	COG0754	glutathionylspermidine amidase activity
IS_RS17055	COG1842	Phage shock protein A
IS_RS17065	COG0259	pyridoxamine-phosphate oxidase activity
IS_RS17070	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IS_RS17075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IS_RS17085	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IS_RS17090	COG2814	Major facilitator Superfamily
IS_RS17115	COG0784	Response regulator, receiver
IS_RS17115	COG2205	protein histidine kinase activity
IS_RS17115	COG2198	Histidine kinase
IS_RS17120	COG2353	YceI-like domain
IS_RS17140	COG1760	l-serine dehydratase
IS_RS17150	COG0460	homoserine dehydrogenase
IS_RS17150	COG0527	aspartate kinase activity
IS_RS17155	COG0626	cystathionine gamma-synthase activity
IS_RS17160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IS_RS17165	COG0739	heme binding
IS_RS17170	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IS_RS17175	COG1272	protein, Hemolysin III
IS_RS17180	COG2982	Protein involved in outer membrane biogenesis
IS_RS17185	COG0516	GMP reductase activity
IS_RS17185	COG0517	IMP dehydrogenase activity
IS_RS17190	COG0463	Glycosyl transferase, family 2
IS_RS17195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS_RS17200	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IS_RS17215	COG1309	transcriptional regulator
IS_RS17225	COG1960	acyl-CoA dehydrogenase activity
IS_RS17250	COG0509	glycine decarboxylation via glycine cleavage system
IS_RS17255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IS_RS17265	COG1742	UPF0060 membrane protein
IS_RS17270	COG3956	TIGRFAM MazG family protein
IS_RS17280	COG0494	nUDIX hydrolase
IS_RS17290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IS_RS17295	COG0837	glucose binding
IS_RS17310	COG3858	chitin binding
IS_RS17310	COG1388	LysM domain
IS_RS17315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IS_RS17325	COG1472	Belongs to the glycosyl hydrolase 3 family
IS_RS17335	COG3537	Alpha-1,2-mannosidase
IS_RS17370	COG3142	Participates in the control of copper homeostasis
IS_RS17375	COG1446	asparaginase
IS_RS17380	COG2304	oxidoreductase activity
IS_RS17385	COG1595	DNA-templated transcription, initiation
IS_RS17415	COG0784	Response regulator, receiver
IS_RS17415	COG2198	Histidine kinase
IS_RS17415	COG0643	Histidine kinase
IS_RS17420	COG0840	transmembrane signaling receptor activity
IS_RS17425	COG0835	chemotaxis
IS_RS17440	COG0189	ligase activity
IS_RS17450	COG1397	ADP-ribosylglycohydrolase
IS_RS17460	COG1397	ADP-ribosylglycohydrolase
IS_RS17470	COG1199	ATP-dependent helicase activity
IS_RS17480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS_RS17485	COG1215	transferase activity, transferring glycosyl groups
IS_RS17495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS_RS17500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IS_RS17505	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IS_RS17510	COG0535	radical SAM domain protein
IS_RS17515	COG0535	radical SAM domain protein
IS_RS17535	COG0837	glucose binding
IS_RS17545	COG1643	Atp-dependent helicase
IS_RS17550	COG0783	Belongs to the Dps family
IS_RS17555	COG0514	ATP-dependent DNA helicase (RecQ)
IS_RS17585	COG1187	pseudouridine synthase activity
IS_RS17595	COG0840	transmembrane signaling receptor activity
IS_RS17615	COG3920	Histidine kinase
IS_RS17620	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IS_RS17630	COG0602	queuosine metabolic process
IS_RS17640	COG2885	chlorophyll binding
IS_RS17645	COG0823	Involved in the tonB-independent uptake of proteins
IS_RS17655	COG0848	biopolymer transport protein
IS_RS17665	COG0824	Thioesterase
IS_RS17670	COG2255	four-way junction helicase activity
IS_RS17680	COG3158	transport of potassium into the cell
IS_RS17685	COG0632	four-way junction helicase activity
IS_RS17690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IS_RS17695	COG0217	transcriptional regulatory protein
IS_RS17710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IS_RS17725	COG0477	Major facilitator Superfamily
IS_RS17740	COG2755	lipolytic protein G-D-S-L family
IS_RS17740	COG0657	acetylesterase activity
IS_RS17760	COG0488	(ABC) transporter
IS_RS17800	COG4772	TonB-dependent receptor
IS_RS17810	COG4264	IucA IucC family
IS_RS17815	COG2814	Major facilitator Superfamily
IS_RS17825	COG0019	diaminopimelate decarboxylase activity
IS_RS17845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IS_RS17855	COG1492	cobalamin metabolic process
IS_RS17865	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IS_RS17885	COG4206	TonB-dependent receptor
IS_RS17890	COG0542	response to heat
IS_RS17930	COG4771	TonB-dependent receptor
IS_RS17935	COG1877	trehalose-phosphatase activity
IS_RS17940	COG3387	PFAM Glycoside hydrolase 15-related
IS_RS17955	COG0840	transmembrane signaling receptor activity
IS_RS17960	COG3011	Protein conserved in bacteria
IS_RS17975	COG0564	pseudouridine synthase activity
IS_RS17980	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS_RS17990	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IS_RS17990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS_RS18005	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IS_RS18010	COG0045	succinate-CoA ligase (ADP-forming) activity
IS_RS18035	COG4969	Belongs to the N-Me-Phe pilin family
IS_RS18045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IS_RS18050	COG0237	dephospho-CoA kinase activity
IS_RS18065	COG2963	transposase activity
IS_RS18075	COG2963	transposase activity
IS_RS18080	COG2801	Transposase and inactivated derivatives
IS_RS18090	COG0745	RESPONSE REGULATOR receiver
IS_RS18100	COG0189	ligase activity
IS_RS18160	COG2801	Transposase and inactivated derivatives
IS_RS18170	COG2963	transposase activity
IS_RS18205	COG3039	Transposase
IS_RS18220	COG2801	Transposase and inactivated derivatives
IS_RS18235	COG3220	belongs to the UPF0276 family
IS_RS18250	COG2003	Belongs to the UPF0758 family
IS_RS18270	COG2801	Transposase and inactivated derivatives
IS_RS18310	COG2022	thiamine diphosphate biosynthetic process
IS_RS18315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IS_RS18320	COG0471	metal ion transport
IS_RS18320	COG3273	potassium ion transport
IS_RS18340	COG1970	mechanosensitive ion channel activity
IS_RS18355	COG1609	Transcriptional regulator
IS_RS18365	COG3250	beta-galactosidase activity
IS_RS18370	COG4948	Mandelate Racemase Muconate Lactonizing
IS_RS18385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS_RS18400	COG0308	aminopeptidase N
IS_RS18430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS_RS18440	COG2895	sulfate adenylyltransferase (ATP) activity
IS_RS18440	COG0529	Catalyzes the synthesis of activated sulfate
IS_RS18445	COG0175	sulfate reduction
IS_RS18450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IS_RS18455	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS_RS18460	COG0175	sulfate reduction
IS_RS18480	COG2205	protein histidine kinase activity
IS_RS18480	COG2198	Histidine kinase
IS_RS18480	COG0784	Response regulator, receiver
IS_RS18500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IS_RS18500	COG1648	precorrin-2 dehydrogenase activity
IS_RS18515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IS_RS18520	COG3588	fructose-bisphosphate aldolase
IS_RS18525	COG0469	pyruvate kinase activity
IS_RS18535	COG0126	phosphoglycerate kinase activity
IS_RS18555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IS_RS18565	COG3047	cAMP biosynthetic process
IS_RS18570	COG3047	cAMP biosynthetic process
IS_RS18580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS_RS18580	COG3453	Protein conserved in bacteria
IS_RS18585	COG0725	ABC transporter, periplasmic molybdate-binding protein
IS_RS18590	COG4149	molybdate abc transporter
IS_RS18595	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IS_RS18630	COG1376	ErfK ybiS ycfS ynhG family protein
IS_RS18635	COG0739	heme binding
IS_RS18640	COG4773	Receptor
IS_RS18645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS_RS18650	COG1301	dicarboxylic acid transport
IS_RS18660	COG2304	oxidoreductase activity
IS_RS18680	COG0714	Associated with various cellular activities
IS_RS18710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IS_RS18730	COG1957	nucleoside hydrolase
IS_RS18735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IS_RS18745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS_RS18755	COG0194	GDP metabolic process
IS_RS18760	COG1561	YicC-like family, N-terminal region
IS_RS18765	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IS_RS18775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IS_RS18780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IS_RS18795	COG0006	proline dipeptidase activity
IS_RS18805	COG0006	proline dipeptidase activity
IS_RS18810	COG3079	Belongs to the UPF0149 family
IS_RS18825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IS_RS18835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IS_RS18845	COG2912	Transglutaminase-like superfamily
IS_RS18850	COG1773	rubredoxin
IS_RS18855	COG0352	thiamine-phosphate diphosphorylase activity
IS_RS18865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IS_RS18875	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
IS_RS18880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IS_RS18910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IS_RS18915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS_RS18920	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS18930	COG0671	phosphoesterase, PA-phosphatase related
IS_RS18935	COG3781	membrane
IS_RS18945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IS_RS18950	COG0563	adenylate kinase activity
IS_RS19015	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IS_RS19025	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IS_RS19045	COG3710	Transcriptional regulator
IS_RS19050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IS_RS19060	COG0840	transmembrane signaling receptor activity
IS_RS19065	COG0405	Gamma-glutamyltransferase
IS_RS19070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IS_RS19090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IS_RS19095	COG0473	3-isopropylmalate dehydrogenase activity
IS_RS19100	COG0066	3-isopropylmalate dehydratase activity
IS_RS19105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IS_RS19125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IS_RS19130	COG1538	Outer membrane efflux protein
IS_RS19135	COG1519	Transferase
IS_RS19140	COG1560	Kdo2-lipid A biosynthetic process
IS_RS19165	COG0280	phosphate acetyltransferase
IS_RS19165	COG0281	malic enzyme
IS_RS19170	COG1301	dicarboxylic acid transport
IS_RS19200	COG0583	DNA-binding transcription factor activity
IS_RS19210	COG0667	Aldo Keto reductase
IS_RS19225	COG2197	response regulator
IS_RS19235	COG0642	Histidine kinase
IS_RS19250	COG2851	Citrate transporter
IS_RS19255	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS19260	COG1609	Transcriptional regulator
IS_RS19265	COG2211	Major facilitator Superfamily
IS_RS19290	COG1162	GTPase activity
IS_RS19310	COG0726	polysaccharide deacetylase
IS_RS19315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IS_RS19330	COG3964	amidohydrolase
IS_RS19335	COG0402	S-adenosylhomocysteine deaminase activity
IS_RS19355	COG1307	EDD domain protein, DegV family
IS_RS19360	COG0242	peptide deformylase activity
IS_RS19380	COG0457	Tetratricopeptide repeat
IS_RS19385	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IS_RS19390	COG1215	transferase activity, transferring glycosyl groups
IS_RS19410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IS_RS19465	COG1450	Type ii and iii secretion system protein
IS_RS19480	COG3166	PFAM Fimbrial assembly family protein
IS_RS19485	COG3156	type II secretion system protein K
IS_RS19490	COG4795	General secretion pathway protein
IS_RS19495	COG2165	general secretion pathway protein
IS_RS19500	COG4970	Tfp pilus assembly protein FimT
IS_RS19505	COG2165	general secretion pathway protein
IS_RS19510	COG1459	type II secretion system
IS_RS19515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IS_RS19520	COG1404	Belongs to the peptidase S8 family
IS_RS19525	COG5295	Hep Hag repeat protein
IS_RS19530	COG1404	Belongs to the peptidase S8 family
IS_RS19535	COG5295	Hep Hag repeat protein
IS_RS19540	COG0047	phosphoribosylformylglycinamidine synthase activity
IS_RS19540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IS_RS19545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS_RS19550	COG4974	Belongs to the 'phage' integrase family
IS_RS19565	COG0795	lipopolysaccharide-transporting ATPase activity
IS_RS19575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IS_RS19590	COG0525	valine-tRNA ligase activity
IS_RS19625	COG1183	phosphatidylcholine synthase activity
IS_RS19635	COG0442	prolyl-tRNA aminoacylation
IS_RS19650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IS_RS19655	COG1127	ABC transporter
IS_RS19660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS_RS19660	COG3218	ABC-type transport auxiliary lipoprotein component
IS_RS19685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IS_RS19690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IS_RS19695	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IS_RS19695	COG0662	Cupin 2, conserved barrel domain protein
IS_RS19725	COG2086	electron transfer activity
IS_RS19740	COG0463	Glycosyl transferase, family 2
IS_RS19765	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IS_RS19770	COG0438	transferase activity, transferring glycosyl groups
IS_RS19790	COG0438	transferase activity, transferring glycosyl groups
IS_RS19795	COG0626	cystathionine gamma-synthase activity
IS_RS19825	COG0625	glutathione transferase activity
IS_RS19835	COG0513	Belongs to the DEAD box helicase family
IS_RS19840	COG0720	synthase
IS_RS19850	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IS_RS19855	COG1956	GAF domain-containing protein
IS_RS19870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS_RS19875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IS_RS19890	COG0339	signal peptide processing
IS_RS19940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS_RS19945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS_RS19950	COG1136	(ABC) transporter
IS_RS19955	COG0577	efflux transmembrane transporter activity
IS_RS19975	COG4191	Histidine kinase
IS_RS19980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IS_RS19995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IS_RS20000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IS_RS20005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IS_RS20010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IS_RS20015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IS_RS20020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IS_RS20030	COG0356	it plays a direct role in the translocation of protons across the membrane
IS_RS20050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS_RS20060	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS_RS20105	COG2011	ABC-type metal ion transport system permease component
IS_RS20110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IS_RS20115	COG0697	spore germination
IS_RS20120	COG1666	GTP binding
IS_RS20130	COG5002	protein histidine kinase activity
IS_RS20130	COG2198	Histidine kinase
IS_RS20130	COG0784	Response regulator, receiver
IS_RS20155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS_RS20160	COG1187	pseudouridine synthase activity
IS_RS20165	COG2813	Specifically methylates the guanine in position
IS_RS20185	COG2205	protein histidine kinase activity
IS_RS20185	COG2202	Pas domain
IS_RS20205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IS_RS20210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS_RS20265	COG0842	Transport permease protein
IS_RS20270	COG1131	(ABC) transporter
IS_RS20275	COG0025	NhaP-type Na H and K H
IS_RS20280	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IS_RS20285	COG1573	uracil-dna glycosylase
IS_RS20295	COG3384	dioxygenase
IS_RS20300	COG0583	DNA-binding transcription factor activity
IS_RS20320	COG3590	peptidase
IS_RS20335	COG0531	amino acid
IS_RS20350	COG2972	Histidine kinase
IS_RS20365	COG3685	Protein conserved in bacteria
IS_RS20370	COG3546	catalase activity
IS_RS20415	COG1271	oxidase subunit
IS_RS20420	COG1294	oxidase, subunit
IS_RS20435	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS20440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IS_RS20460	COG1132	(ABC) transporter
IS_RS20475	COG1063	alcohol dehydrogenase
IS_RS20550	COG0251	oxidation-reduction process
IS_RS20565	COG0583	DNA-binding transcription factor activity
IS_RS20570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IS_RS20600	COG0659	secondary active sulfate transmembrane transporter activity
IS_RS20605	COG0038	chloride channel
IS_RS20615	COG0024	Methionine aminopeptidase
IS_RS20630	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS20690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS_RS20695	COG1490	D-aminoacyl-tRNA deacylase activity
IS_RS20700	COG1560	Kdo2-lipid A biosynthetic process
IS_RS20755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IS_RS20755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IS_RS20760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IS_RS20765	COG0242	peptide deformylase activity
IS_RS20770	COG1652	LysM domain
IS_RS20775	COG0758	DNA mediated transformation
IS_RS20780	COG2922	Belongs to the Smg family
IS_RS20795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IS_RS20795	COG1754	DNA topoisomerase type I activity
IS_RS20800	COG0009	L-threonylcarbamoyladenylate synthase
IS_RS20815	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS20825	COG0616	signal peptide processing
IS_RS20830	COG0534	Mate efflux family protein
IS_RS20850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IS_RS20870	COG1252	NADH dehydrogenase
IS_RS20875	COG2860	membrane
IS_RS20880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS_RS20885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IS_RS20890	COG2201	protein-glutamate methylesterase activity
IS_RS20895	COG2177	Part of the ABC transporter FtsEX involved in
IS_RS20900	COG2884	Cell division ATP-binding protein ftsE
IS_RS20905	COG0513	Belongs to the DEAD box helicase family
IS_RS20910	COG3118	belongs to the thioredoxin family
IS_RS20915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IS_RS20925	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IS_RS20930	COG0583	DNA-binding transcription factor activity
IS_RS20950	COG1652	LysM domain
IS_RS20955	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IS_RS20955	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IS_RS20960	COG1473	amidohydrolase
IS_RS20965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS_RS20970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS_RS20980	COG5383	Protein conserved in bacteria
IS_RS21020	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IS_RS21025	COG3023	N-Acetylmuramoyl-L-alanine amidase
IS_RS21035	COG4948	Mandelate Racemase Muconate Lactonizing
IS_RS21045	COG0531	amino acid
IS_RS21060	COG4682	membrane
IS_RS21065	COG2133	pyrroloquinoline quinone binding
IS_RS21075	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS_RS21080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IS_RS21090	COG1610	YqeY-like protein
IS_RS21095	COG1295	ribonuclease BN
IS_RS21100	COG0358	DNA primase activity
IS_RS21115	COG0109	protoheme IX farnesyltransferase activity
IS_RS21145	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IS_RS21160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IS_RS21200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IS_RS21205	COG0739	heme binding
IS_RS21210	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IS_RS21220	COG2223	nitrite transmembrane transporter activity
IS_RS21225	COG0708	Exodeoxyribonuclease III
IS_RS21230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IS_RS21240	COG1192	Involved in chromosome partitioning
IS_RS21245	COG1475	DNA binding
IS_RS21260	COG0463	Glycosyl transferase, family 2
IS_RS21280	COG0756	dUTP diphosphatase activity
IS_RS21285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IS_RS21290	COG2003	Belongs to the UPF0758 family
IS_RS21295	COG0018	arginyl-trna synthetase
IS_RS21310	COG4221	oxidoreductase activity
IS_RS21340	COG1166	arginine decarboxylase activity
IS_RS21345	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IS_RS21370	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IS_RS21370	COG3291	Pkd domain containing protein
IS_RS21385	COG0606	chelatase, subunit chli
IS_RS21400	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IS_RS21440	COG1690	Belongs to the RtcB family
IS_RS21480	COG1090	epimerase
IS_RS21490	COG0642	Histidine kinase
IS_RS21510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS_RS21530	COG0628	permease
IS_RS21535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS_RS21540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IS_RS21555	COG0753	catalase activity
IS_RS21570	COG2197	response regulator
IS_RS21575	COG4585	Histidine kinase
IS_RS21580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS_RS21585	COG1136	(ABC) transporter
IS_RS21610	COG0697	spore germination
IS_RS21625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS_RS21630	COG0180	Tryptophanyl-tRNA synthetase
IS_RS21635	COG3237	CsbD-like
IS_RS21675	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IS_RS21695	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IS_RS21700	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IS_RS21700	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IS_RS21740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS_RS21765	COG1199	ATP-dependent helicase activity
IS_RS21780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS_RS21830	COG0625	glutathione transferase activity
IS_RS21870	COG4555	ABC transporter
IS_RS21880	COG1476	TRANSCRIPTIONal
IS_RS21905	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IS_RS21910	COG1131	(ABC) transporter
IS_RS21915	COG0842	Transport permease protein
IS_RS21920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IS_RS21945	COG0716	FMN binding
IS_RS21950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS_RS21955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS_RS21965	COG1042	CoA-binding domain protein
IS_RS21965	COG0045	succinate-CoA ligase (ADP-forming) activity
IS_RS21965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS_RS21970	COG2239	Acts as a magnesium transporter
IS_RS21995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IS_RS22000	COG3387	PFAM Glycoside hydrolase 15-related
IS_RS22010	COG3100	YcgL domain-containing protein
IS_RS22015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS_RS22025	COG0463	Glycosyl transferase, family 2
IS_RS22035	COG3039	Transposase
IS_RS22045	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS22085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IS_RS22100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IS_RS22135	COG0408	coproporphyrinogen oxidase activity
IS_RS22175	COG0515	serine threonine protein kinase
IS_RS22180	COG0631	protein serine/threonine phosphatase activity
IS_RS22205	COG0667	Aldo Keto reductase
IS_RS22210	COG0583	DNA-binding transcription factor activity
IS_RS22305	COG2963	transposase activity
IS_RS22375	COG0210	DNA helicase
IS_RS22390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS_RS22395	COG0583	DNA-binding transcription factor activity
IS_RS22400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IS_RS22410	COG2159	amidohydrolase
IS_RS22435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS_RS22455	COG0357	Ribosomal RNA small subunit methyltransferase G
IS_RS22460	COG3540	Alkaline phosphatase
IS_RS22470	COG2091	lysine biosynthetic process via aminoadipic acid
IS_RS22490	COG0708	Exodeoxyribonuclease III
IS_RS22500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS_RS22505	COG3162	membrane
IS_RS22515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IS_RS22545	COG3507	Belongs to the glycosyl hydrolase 43 family
IS_RS22565	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS22570	COG0179	Fumarylacetoacetate (FAA) hydrolase
IS_RS22575	COG4948	Mandelate Racemase Muconate Lactonizing
IS_RS22580	COG3254	rhamnose metabolic process
IS_RS22585	COG0738	Major facilitator superfamily
IS_RS22590	COG1414	Transcriptional regulator
IS_RS22595	COG1971	Probably functions as a manganese efflux pump
IS_RS22600	COG2205	protein histidine kinase activity
IS_RS22610	COG3459	Glycosyltransferase 36 associated
IS_RS22615	COG2211	Major facilitator Superfamily
IS_RS22620	COG3265	gluconokinase activity
IS_RS22625	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS_RS22645	COG2911	Protein conserved in bacteria
IS_RS22650	COG0729	surface antigen
IS_RS22665	COG0457	Tetratricopeptide repeat
IS_RS22675	COG0752	glycyl-tRNA synthetase alpha subunit
IS_RS22680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IS_RS22690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IS_RS22690	COG0519	Catalyzes the synthesis of GMP from XMP
IS_RS22700	COG0805	protein transport
IS_RS22705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IS_RS22710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IS_RS22720	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IS_RS22740	COG2974	May be involved in recombination
IS_RS22745	COG0037	tRNA processing
IS_RS22750	COG2115	Belongs to the xylose isomerase family
IS_RS22760	COG3661	Belongs to the glycosyl hydrolase 67 family
IS_RS22770	COG4948	Mandelate Racemase Muconate Lactonizing
IS_RS22780	COG1472	Belongs to the glycosyl hydrolase 3 family
IS_RS22785	COG0246	Mannitol dehydrogenase
IS_RS22835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IS_RS22860	COG3386	PFAM SMP-30 Gluconolaconase
IS_RS22870	COG3250	beta-galactosidase activity
IS_RS22875	COG1904	glucuronate isomerase
IS_RS22880	COG3693	PFAM glycoside hydrolase, family 10
IS_RS22890	COG3693	PFAM glycoside hydrolase, family 10
IS_RS22905	COG2211	Major facilitator Superfamily
IS_RS22940	COG0604	alcohol dehydrogenase
IS_RS22940	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS22940	COG3321	synthase
IS_RS22945	COG2937	Belongs to the GPAT DAPAT family
IS_RS22980	COG0284	orotidine-5'-phosphate decarboxylase activity
IS_RS22985	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IS_RS22990	COG3132	Protein of unknown function, DUF480
IS_RS23005	COG0210	DNA helicase
IS_RS23010	COG1435	thymidine kinase activity
IS_RS23020	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IS_RS23030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IS_RS23060	COG3135	benzoate transporter
IS_RS23080	COG0676	glucose-6-phosphate 1-epimerase activity
IS_RS23090	COG3012	SEC-C Motif Domain Protein
IS_RS23095	COG0730	response to heat
IS_RS23115	COG0302	gtp cyclohydrolase
IS_RS23130	COG1566	PFAM secretion protein HlyD family protein
IS_RS23140	COG1289	transmembrane transporter activity
IS_RS23145	COG0477	Major facilitator Superfamily
IS_RS23165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS_RS23235	COG0564	pseudouridine synthase activity
IS_RS23270	COG1309	transcriptional regulator
IS_RS23280	COG1028	Short-chain dehydrogenase reductase Sdr
IS_RS23315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IS_RS23320	COG1074	ATP-dependent DNA helicase activity
IS_RS23325	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IS_RS23360	COG1127	ABC transporter
IS_RS23365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IS_RS23370	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS_RS23385	COG2853	Lipoprotein
IS_RS23395	COG0386	Belongs to the glutathione peroxidase family
IS_RS23405	COG1322	Protein conserved in bacteria
IS_RS23410	COG0604	alcohol dehydrogenase
IS_RS23435	COG0531	amino acid
IS_RS23440	COG3537	Alpha-1,2-mannosidase
IS_RS23445	COG4206	TonB-dependent receptor
IS_RS23455	COG3706	GGDEF domain
IS_RS23460	COG3835	regulator
IS_RS23465	COG1929	Belongs to the glycerate kinase type-1 family
IS_RS23470	COG2271	Major facilitator Superfamily
IS_RS23485	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IS_RS23490	COG0861	Integral membrane protein TerC family
IS_RS23500	COG0584	glycerophosphoryl diester phosphodiesterase
IS_RS23515	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IS_RS23520	COG0726	polysaccharide deacetylase
IS_RS23525	COG0706	membrane insertase activity
IS_RS23530	COG0594	ribonuclease P activity
IS_RS23610	COG4221	oxidoreductase activity
IS_RS23645	COG0667	Aldo Keto reductase