locus-tag	class	description
FYK61_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FYK61_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FYK61_RS00020	COG0187	DNA topoisomerase II activity
FYK61_RS00030	COG0501	Belongs to the peptidase M48B family
FYK61_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FYK61_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FYK61_RS00120	COG0793	Belongs to the peptidase S41A family
FYK61_RS00125	COG4942	peptidase
FYK61_RS00135	COG2234	aminopeptidase activity
FYK61_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FYK61_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FYK61_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FYK61_RS00165	COG1064	alcohol dehydrogenase
FYK61_RS00175	COG0493	'glutamate synthase
FYK61_RS00180	COG0070	glutamate synthase
FYK61_RS00180	COG0069	glutamate synthase activity
FYK61_RS00180	COG0067	glutamate synthase
FYK61_RS00265	COG1111	helicase
FYK61_RS00265	COG1205	dead DEAH box helicase
FYK61_RS00270	COG1272	protein, Hemolysin III
FYK61_RS00290	COG0300	oxidoreductase activity
FYK61_RS00295	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS00315	COG2249	NAD(P)H dehydrogenase (quinone) activity
FYK61_RS00340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FYK61_RS00365	COG3237	CsbD-like
FYK61_RS00415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FYK61_RS00420	COG0477	Major facilitator Superfamily
FYK61_RS00460	COG0714	Associated with various cellular activities
FYK61_RS00490	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FYK61_RS00500	COG4772	TonB-dependent receptor
FYK61_RS00515	COG1012	belongs to the aldehyde dehydrogenase family
FYK61_RS00540	COG1304	FMN binding
FYK61_RS00550	COG4585	Histidine kinase
FYK61_RS00555	COG2197	response regulator
FYK61_RS00575	COG3710	Transcriptional regulator
FYK61_RS00580	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FYK61_RS00685	COG0366	Alpha amylase catalytic
FYK61_RS00690	COG0366	Alpha amylase catalytic
FYK61_RS00695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FYK61_RS00715	COG0657	acetylesterase activity
FYK61_RS00715	COG2755	lipolytic protein G-D-S-L family
FYK61_RS00725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FYK61_RS00740	COG3507	Belongs to the glycosyl hydrolase 43 family
FYK61_RS00745	COG1609	Transcriptional regulator
FYK61_RS00750	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FYK61_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS00765	COG2755	lipolytic protein G-D-S-L family
FYK61_RS00775	COG3186	Phenylalanine-4-hydroxylase
FYK61_RS00780	COG1522	sequence-specific DNA binding
FYK61_RS00790	COG1752	Esterase of the alpha-beta hydrolase superfamily
FYK61_RS00800	COG1119	ATPase activity
FYK61_RS00815	COG1125	glycine betaine transport
FYK61_RS00830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FYK61_RS00860	COG0489	protein tyrosine kinase activity
FYK61_RS00865	COG2062	phosphohistidine phosphatase, SixA
FYK61_RS00875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FYK61_RS00920	COG1968	undecaprenyl-diphosphatase activity
FYK61_RS00925	COG0174	glutamine synthetase
FYK61_RS00930	COG0347	Belongs to the P(II) protein family
FYK61_RS00935	COG0004	ammonium transporteR
FYK61_RS00940	COG3852	Histidine kinase
FYK61_RS00945	COG2204	response regulator
FYK61_RS00950	COG2032	superoxide dismutase activity
FYK61_RS00955	COG2032	superoxide dismutase activity
FYK61_RS00980	COG0183	Belongs to the thiolase family
FYK61_RS01015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FYK61_RS01020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FYK61_RS01025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FYK61_RS01040	COG0028	Belongs to the TPP enzyme family
FYK61_RS01045	COG2205	protein histidine kinase activity
FYK61_RS01070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FYK61_RS01085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FYK61_RS01095	COG0596	Alpha beta hydrolase
FYK61_RS01100	COG0727	PFAM Uncharacterised protein family (UPF0153)
FYK61_RS01105	COG0318	PFAM AMP-dependent synthetase and ligase
FYK61_RS01110	COG0745	RESPONSE REGULATOR receiver
FYK61_RS01120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FYK61_RS01140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FYK61_RS01150	COG0564	pseudouridine synthase activity
FYK61_RS01170	COG1446	asparaginase
FYK61_RS01175	COG0339	signal peptide processing
FYK61_RS01210	COG0475	glutathione-regulated potassium exporter activity
FYK61_RS01215	COG0583	DNA-binding transcription factor activity
FYK61_RS01220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FYK61_RS01225	COG2224	Isocitrate lyase
FYK61_RS01255	COG4770	biotin carboxylase activity
FYK61_RS01260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FYK61_RS01265	COG1960	acyl-CoA dehydrogenase activity
FYK61_RS01330	COG0697	spore germination
FYK61_RS01340	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FYK61_RS01345	COG1846	Transcriptional regulator
FYK61_RS01350	COG1764	response to oxidative stress
FYK61_RS01375	COG2130	NADP-dependent
FYK61_RS01390	COG1187	pseudouridine synthase activity
FYK61_RS01405	COG1643	Atp-dependent helicase
FYK61_RS01410	COG4807	Protein conserved in bacteria
FYK61_RS01415	COG2351	hydroxyisourate hydrolase activity
FYK61_RS01420	COG2072	flavoprotein involved in K transport
FYK61_RS01440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FYK61_RS01485	COG2252	PERMEase
FYK61_RS01505	COG0084	hydrolase, TatD family'
FYK61_RS01515	COG0583	DNA-binding transcription factor activity
FYK61_RS01520	COG2814	Major facilitator Superfamily
FYK61_RS01530	COG2267	carboxylic ester hydrolase activity
FYK61_RS01535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FYK61_RS01540	COG1902	pentaerythritol trinitrate reductase activity
FYK61_RS01560	COG0745	RESPONSE REGULATOR receiver
FYK61_RS01565	COG2205	protein histidine kinase activity
FYK61_RS01570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FYK61_RS01590	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FYK61_RS01595	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FYK61_RS01600	COG0583	DNA-binding transcription factor activity
FYK61_RS01630	COG0702	epimerase
FYK61_RS01635	COG1733	regulation of RNA biosynthetic process
FYK61_RS01660	COG0129	dihydroxy-acid dehydratase activity
FYK61_RS01675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FYK61_RS01730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FYK61_RS01735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FYK61_RS01760	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FYK61_RS01765	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FYK61_RS01775	COG3485	protocatechuate 3,4-dioxygenase
FYK61_RS01780	COG3485	protocatechuate 3,4-dioxygenase
FYK61_RS01790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FYK61_RS01795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FYK61_RS01805	COG1414	Transcriptional regulator
FYK61_RS01815	COG0657	acetylesterase activity
FYK61_RS01825	COG0445	tRNA wobble uridine modification
FYK61_RS01835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FYK61_RS01860	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS01865	COG2267	carboxylic ester hydrolase activity
FYK61_RS01875	COG0156	8-amino-7-oxononanoate synthase activity
FYK61_RS01880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FYK61_RS01885	COG1040	competence protein
FYK61_RS01890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FYK61_RS01960	COG1196	nuclear chromosome segregation
FYK61_RS02010	COG5297	Belongs to the glycosyl hydrolase family 6
FYK61_RS02065	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FYK61_RS02135	COG1511	domain protein
FYK61_RS02135	COG3264	Mechanosensitive ion channel
FYK61_RS02140	COG1368	sulfuric ester hydrolase activity
FYK61_RS02145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FYK61_RS02150	COG2354	Protein conserved in bacteria
FYK61_RS02160	COG0297	glycogen (starch) synthase activity
FYK61_RS02165	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FYK61_RS02170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FYK61_RS02195	COG0702	epimerase
FYK61_RS02200	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS02230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FYK61_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS02245	COG0513	Belongs to the DEAD box helicase family
FYK61_RS02250	COG0508	dehydrogenase complex catalyzes the overall conversion of
FYK61_RS02265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FYK61_RS02275	COG3483	tryptophan 2,3-dioxygenase activity
FYK61_RS02280	COG3104	oligopeptide transport
FYK61_RS02300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FYK61_RS02315	COG1320	monovalent cation:proton antiporter activity
FYK61_RS02320	COG2212	antiporter activity
FYK61_RS02330	COG0651	ATP synthesis coupled electron transport
FYK61_RS02335	COG1006	Multisubunit Na H antiporter MnhC subunit
FYK61_RS02340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FYK61_RS02340	COG2111	Na H antiporter
FYK61_RS02365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FYK61_RS02370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FYK61_RS02385	COG0456	acetyltransferase
FYK61_RS02390	COG1597	lipid kinase activity
FYK61_RS02420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FYK61_RS02425	COG0134	indole-3-glycerol-phosphate synthase activity
FYK61_RS02435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FYK61_RS02440	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FYK61_RS02450	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FYK61_RS02460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FYK61_RS02475	COG1051	belongs to the nudix hydrolase family
FYK61_RS02515	COG0316	Belongs to the HesB IscA family
FYK61_RS02530	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FYK61_RS02545	COG2814	Major facilitator Superfamily
FYK61_RS02555	COG2814	Major facilitator Superfamily
FYK61_RS02560	COG1289	transmembrane transporter activity
FYK61_RS02565	COG0151	Belongs to the GarS family
FYK61_RS02575	COG0138	bifunctional purine biosynthesis protein purh
FYK61_RS02580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FYK61_RS02585	COG2267	carboxylic ester hydrolase activity
FYK61_RS02590	COG0671	phosphoesterase, PA-phosphatase related
FYK61_RS02590	COG2453	phosphatase
FYK61_RS02615	COG4589	Belongs to the CDS family
FYK61_RS02620	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FYK61_RS02645	COG2264	protein methyltransferase activity
FYK61_RS02660	COG0439	Biotin carboxylase
FYK61_RS02670	COG0511	ligase activity, forming carbon-carbon bonds
FYK61_RS02675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FYK61_RS02685	COG1324	tolerance protein
FYK61_RS02695	COG2356	endonuclease I
FYK61_RS02705	COG0459	protein refolding
FYK61_RS02725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FYK61_RS02740	COG3386	PFAM SMP-30 Gluconolaconase
FYK61_RS02750	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FYK61_RS02755	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FYK61_RS02780	COG0778	Nitroreductase
FYK61_RS02785	COG2353	YceI-like domain
FYK61_RS02810	COG3052	prosthetic group binding
FYK61_RS02840	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FYK61_RS02850	COG1802	Transcriptional regulator
FYK61_RS02970	COG1082	Xylose isomerase domain protein TIM barrel
FYK61_RS02985	COG4221	oxidoreductase activity
FYK61_RS03000	COG4221	oxidoreductase activity
FYK61_RS03010	COG0435	Glutathione S-transferase
FYK61_RS03045	COG1506	peptidase
FYK61_RS03045	COG0823	Involved in the tonB-independent uptake of proteins
FYK61_RS03080	COG0697	spore germination
FYK61_RS03095	COG1113	amino acid transport
FYK61_RS03115	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FYK61_RS03160	COG0840	transmembrane signaling receptor activity
FYK61_RS03165	COG5297	Belongs to the glycosyl hydrolase family 6
FYK61_RS03165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FYK61_RS03170	COG0659	secondary active sulfate transmembrane transporter activity
FYK61_RS03185	COG2943	transferase activity, transferring hexosyl groups
FYK61_RS03195	COG3275	phosphorelay sensor kinase activity
FYK61_RS03205	COG0181	hydroxymethylbilane synthase activity
FYK61_RS03230	COG1505	serine-type exopeptidase activity
FYK61_RS03235	COG0436	Aminotransferase
FYK61_RS03245	COG2832	Protein of unknown function (DUF454)
FYK61_RS03255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FYK61_RS03265	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FYK61_RS03270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FYK61_RS03275	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FYK61_RS03300	COG2226	methyltransferase
FYK61_RS03305	COG3300	MHYT domain
FYK61_RS03305	COG5001	Diguanylate cyclase
FYK61_RS03310	COG0308	aminopeptidase N
FYK61_RS03355	COG3284	Transcriptional regulator
FYK61_RS03360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FYK61_RS03365	COG1077	Cell shape determining protein MreB Mrl
FYK61_RS03370	COG1792	Involved in formation and maintenance of cell shape
FYK61_RS03385	COG0772	Belongs to the SEDS family
FYK61_RS03395	COG2951	lytic endotransglycosylase activity
FYK61_RS03400	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FYK61_RS03405	COG1686	Belongs to the peptidase S11 family
FYK61_RS03415	COG2921	Belongs to the UPF0250 family
FYK61_RS03420	COG0321	lipoyl(octanoyl) transferase activity
FYK61_RS03425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FYK61_RS03440	COG0583	DNA-binding transcription factor activity
FYK61_RS03450	COG1056	cytidyltransferase-related domain
FYK61_RS03450	COG1051	belongs to the nudix hydrolase family
FYK61_RS03485	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FYK61_RS03490	COG0673	inositol 2-dehydrogenase activity
FYK61_RS03495	COG2823	Periplasmic or secreted lipoprotein
FYK61_RS03500	COG4251	negative regulation of phosphorylation
FYK61_RS03505	COG0784	Response regulator, receiver
FYK61_RS03510	COG4191	Histidine kinase
FYK61_RS03515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FYK61_RS03570	COG1459	type II secretion system
FYK61_RS03575	COG2165	general secretion pathway protein
FYK61_RS03590	COG4795	General secretion pathway protein
FYK61_RS03620	COG3250	beta-galactosidase activity
FYK61_RS03635	COG2188	Transcriptional regulator
FYK61_RS03645	COG1609	Transcriptional regulator
FYK61_RS03650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FYK61_RS03655	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FYK61_RS03670	COG0617	tRNA 3'-terminal CCA addition
FYK61_RS03675	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FYK61_RS03680	COG1012	belongs to the aldehyde dehydrogenase family
FYK61_RS03685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FYK61_RS03700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FYK61_RS03715	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FYK61_RS03720	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FYK61_RS03735	COG2205	protein histidine kinase activity
FYK61_RS03765	COG3791	Glutathione-dependent formaldehyde-activating
FYK61_RS03780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FYK61_RS03790	COG0697	spore germination
FYK61_RS03800	COG0488	(ABC) transporter
FYK61_RS03810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FYK61_RS03815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FYK61_RS03825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FYK61_RS03825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FYK61_RS03845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FYK61_RS03850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FYK61_RS03855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FYK61_RS03875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FYK61_RS03880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FYK61_RS03885	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FYK61_RS03890	COG2205	protein histidine kinase activity
FYK61_RS03895	COG0745	RESPONSE REGULATOR receiver
FYK61_RS03915	COG0277	FAD linked oxidase domain protein
FYK61_RS03920	COG1988	membrane-bound metal-dependent
FYK61_RS03925	COG0792	nuclease activity
FYK61_RS03955	COG0275	rRNA processing
FYK61_RS03960	COG3116	cell division
FYK61_RS03970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FYK61_RS03975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FYK61_RS03980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FYK61_RS03990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FYK61_RS03995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FYK61_RS04000	COG1181	Belongs to the D-alanine--D-alanine ligase family
FYK61_RS04005	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FYK61_RS04020	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FYK61_RS04030	COG0739	heme binding
FYK61_RS04035	COG0653	protein targeting
FYK61_RS04040	COG0494	nUDIX hydrolase
FYK61_RS04050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FYK61_RS04060	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS04060	COG0604	alcohol dehydrogenase
FYK61_RS04060	COG3321	synthase
FYK61_RS04080	COG0366	Alpha amylase catalytic
FYK61_RS04115	COG2226	methyltransferase
FYK61_RS04120	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FYK61_RS04130	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FYK61_RS04170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FYK61_RS04180	COG4106	trans-aconitate 2-methyltransferase activity
FYK61_RS04185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FYK61_RS04195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FYK61_RS04200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FYK61_RS04205	COG0667	Aldo Keto reductase
FYK61_RS04215	COG4771	TonB-dependent receptor
FYK61_RS04235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FYK61_RS04240	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FYK61_RS04250	COG2175	clavaminate synthase activity
FYK61_RS04260	COG4181	ATPase activity
FYK61_RS04275	COG0642	Histidine kinase
FYK61_RS04285	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FYK61_RS04305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FYK61_RS04310	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FYK61_RS04325	COG3829	transcription factor binding
FYK61_RS04335	COG1116	anion transmembrane transporter activity
FYK61_RS04340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FYK61_RS04350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FYK61_RS04355	COG0431	NADPH-dependent FMN reductase
FYK61_RS04380	COG0747	negative chemotaxis
FYK61_RS04390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FYK61_RS04400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FYK61_RS04405	COG2967	ApaG domain
FYK61_RS04410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FYK61_RS04415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FYK61_RS04420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FYK61_RS04425	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FYK61_RS04430	COG0123	including yeast histone deacetylase and acetoin utilization protein
FYK61_RS04435	COG2096	Adenosyltransferase
FYK61_RS04450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FYK61_RS04455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FYK61_RS04485	COG3384	dioxygenase
FYK61_RS04490	COG0583	DNA-binding transcription factor activity
FYK61_RS04505	COG1024	Enoyl-CoA hydratase
FYK61_RS04535	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FYK61_RS04560	COG0697	spore germination
FYK61_RS04570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FYK61_RS04595	COG2197	response regulator
FYK61_RS04605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FYK61_RS04615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FYK61_RS04620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FYK61_RS04625	COG0583	DNA-binding transcription factor activity
FYK61_RS04630	COG3634	alkyl hydroperoxide reductase activity
FYK61_RS04640	COG2890	protein-(glutamine-N5) methyltransferase activity
FYK61_RS04660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FYK61_RS04660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FYK61_RS04730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FYK61_RS04735	COG1404	Belongs to the peptidase S8 family
FYK61_RS04740	COG1404	Belongs to the peptidase S8 family
FYK61_RS04745	COG1404	Belongs to the peptidase S8 family
FYK61_RS04750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FYK61_RS04775	COG1295	ribonuclease BN
FYK61_RS04780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FYK61_RS04785	COG1254	Belongs to the acylphosphatase family
FYK61_RS04800	COG0521	Mo-molybdopterin cofactor biosynthetic process
FYK61_RS04810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FYK61_RS04815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FYK61_RS04825	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FYK61_RS04830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FYK61_RS04840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FYK61_RS04845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FYK61_RS04850	COG0193	aminoacyl-tRNA hydrolase activity
FYK61_RS04855	COG0012	GTP binding
FYK61_RS04875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FYK61_RS04890	COG0250	Participates in transcription elongation, termination and antitermination
FYK61_RS04895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FYK61_RS04900	COG0081	regulation of translation
FYK61_RS04905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FYK61_RS04910	COG0222	ribosome binding
FYK61_RS04915	COG0085	RNA polymerase activity
FYK61_RS04920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FYK61_RS04925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FYK61_RS04930	COG0049	tRNA binding
FYK61_RS04935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FYK61_RS04940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FYK61_RS04945	COG0051	transcription antitermination factor activity, RNA binding
FYK61_RS04950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FYK61_RS04955	COG0088	Forms part of the polypeptide exit tunnel
FYK61_RS04965	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FYK61_RS04970	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FYK61_RS04980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FYK61_RS04985	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FYK61_RS04990	COG0255	Belongs to the universal ribosomal protein uL29 family
FYK61_RS04995	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FYK61_RS05005	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FYK61_RS05010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FYK61_RS05020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FYK61_RS05025	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FYK61_RS05030	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FYK61_RS05040	COG1841	ribosomal large subunit assembly
FYK61_RS05045	COG0200	Binds to the 23S rRNA
FYK61_RS05050	COG0201	protein transport
FYK61_RS05075	COG0203	ribosomal protein L17
FYK61_RS05080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FYK61_RS05095	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FYK61_RS05110	COG0154	amidase activity
FYK61_RS05120	COG1217	gtp-binding protein TYPA
FYK61_RS05125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FYK61_RS05130	COG0039	L-malate dehydrogenase activity
FYK61_RS05135	COG0625	glutathione transferase activity
FYK61_RS05145	COG1902	pentaerythritol trinitrate reductase activity
FYK61_RS05145	COG0446	pyridine nucleotide-disulphide oxidoreductase
FYK61_RS05150	COG0604	alcohol dehydrogenase
FYK61_RS05175	COG0156	8-amino-7-oxononanoate synthase activity
FYK61_RS05180	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FYK61_RS05185	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FYK61_RS05190	COG4208	sulfate ABC transporter
FYK61_RS05195	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FYK61_RS05225	COG0406	alpha-ribazole phosphatase activity
FYK61_RS05230	COG0285	dihydrofolate synthase activity
FYK61_RS05250	COG2833	Protein of unknown function (DUF455)
FYK61_RS05255	COG3291	Pkd domain containing protein
FYK61_RS05265	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FYK61_RS05270	COG0671	phosphoesterase, PA-phosphatase related
FYK61_RS05275	COG0438	transferase activity, transferring glycosyl groups
FYK61_RS05285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FYK61_RS05300	COG4783	chaperone-mediated protein folding
FYK61_RS05315	COG0473	3-isopropylmalate dehydrogenase activity
FYK61_RS05345	COG3852	Histidine kinase
FYK61_RS05355	COG0544	peptidyl-prolyl cis-trans isomerase activity
FYK61_RS05365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FYK61_RS05395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FYK61_RS05405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FYK61_RS05415	COG0328	RNA-DNA hybrid ribonuclease activity
FYK61_RS05420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FYK61_RS05425	COG0631	protein serine/threonine phosphatase activity
FYK61_RS05440	COG0859	PFAM glycosyl transferase family 9
FYK61_RS05445	COG3642	lipopolysaccharide core region biosynthetic process
FYK61_RS05450	COG1234	tRNA 3'-trailer cleavage
FYK61_RS05455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FYK61_RS05465	COG0315	cyclic pyranopterin monophosphate synthase activity
FYK61_RS05470	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FYK61_RS05475	COG0314	molybdopterin synthase activity
FYK61_RS05525	COG1074	ATP-dependent DNA helicase activity
FYK61_RS05545	COG2003	Belongs to the UPF0758 family
FYK61_RS05605	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FYK61_RS05610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FYK61_RS05615	COG0537	adenosine 5'-monophosphoramidase activity
FYK61_RS05635	COG0714	Associated with various cellular activities
FYK61_RS05660	COG0424	maF-like protein
FYK61_RS05665	COG1399	metal-binding, possibly nucleic acid-binding protein
FYK61_RS05675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FYK61_RS05685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FYK61_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS05705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FYK61_RS05710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FYK61_RS05735	COG3829	transcription factor binding
FYK61_RS05775	COG2373	Large extracellular alpha-helical protein
FYK61_RS05790	COG4953	penicillin-binding protein 1C
FYK61_RS05800	COG0678	peroxiredoxin activity
FYK61_RS05820	COG0330	HflC and HflK could
FYK61_RS05825	COG0330	HflC and HflK could
FYK61_RS05835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FYK61_RS05840	COG0308	aminopeptidase N
FYK61_RS05850	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS05855	COG1309	transcriptional regulator
FYK61_RS05910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FYK61_RS05945	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FYK61_RS05955	COG3387	PFAM Glycoside hydrolase 15-related
FYK61_RS05960	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS05965	COG3537	Alpha-1,2-mannosidase
FYK61_RS05970	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS05985	COG0492	ferredoxin-NADP+ reductase activity
FYK61_RS06015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FYK61_RS06020	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FYK61_RS06025	COG2080	2 iron, 2 sulfur cluster binding
FYK61_RS06060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FYK61_RS06075	COG0587	DNA-directed DNA polymerase activity
FYK61_RS06090	COG1297	OPT oligopeptide transporter protein
FYK61_RS06105	COG1506	peptidase
FYK61_RS06105	COG0823	Involved in the tonB-independent uptake of proteins
FYK61_RS06120	COG2207	Transcriptional regulator
FYK61_RS06120	COG1917	Cupin 2, conserved barrel domain protein
FYK61_RS06140	COG0753	catalase activity
FYK61_RS06145	COG0656	L-ascorbic acid biosynthetic process
FYK61_RS06155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FYK61_RS06155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FYK61_RS06160	COG2814	Major facilitator Superfamily
FYK61_RS06175	COG2194	sulfuric ester hydrolase activity
FYK61_RS06190	COG0745	RESPONSE REGULATOR receiver
FYK61_RS06195	COG0642	Histidine kinase
FYK61_RS06205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FYK61_RS06210	COG2894	cell division
FYK61_RS06215	COG0850	regulation of cytokinetic process
FYK61_RS06225	COG4585	Histidine kinase
FYK61_RS06230	COG2197	response regulator
FYK61_RS06245	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FYK61_RS06270	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FYK61_RS06280	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FYK61_RS06300	COG1946	Acyl-CoA thioesterase
FYK61_RS06315	COG0824	Thioesterase
FYK61_RS06320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FYK61_RS06325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FYK61_RS06330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FYK61_RS06335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FYK61_RS06340	COG0268	Binds directly to 16S ribosomal RNA
FYK61_RS06350	COG0196	riboflavin kinase activity
FYK61_RS06355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FYK61_RS06360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FYK61_RS06365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FYK61_RS06400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FYK61_RS06405	COG1845	cytochrome c oxidase, subunit III
FYK61_RS06410	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FYK61_RS06425	COG3152	Membrane
FYK61_RS06435	COG2207	Transcriptional regulator
FYK61_RS06450	COG1366	Belongs to the anti-sigma-factor antagonist family
FYK61_RS06455	COG1366	Belongs to the anti-sigma-factor antagonist family
FYK61_RS06460	COG2172	sigma factor antagonist activity
FYK61_RS06485	COG4771	TonB-dependent receptor
FYK61_RS06495	COG5507	3-demethylubiquinone-9 3-methyltransferase
FYK61_RS06500	COG2205	protein histidine kinase activity
FYK61_RS06510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FYK61_RS06515	COG4999	Histidine kinase
FYK61_RS06515	COG3850	Histidine kinase
FYK61_RS06515	COG3437	response regulator, receiver
FYK61_RS06515	COG2205	protein histidine kinase activity
FYK61_RS06520	COG4191	Histidine kinase
FYK61_RS06520	COG0784	Response regulator, receiver
FYK61_RS06545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FYK61_RS06550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FYK61_RS06560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FYK61_RS06565	COG0228	four-way junction DNA binding
FYK61_RS06570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FYK61_RS06575	COG0336	Belongs to the RNA methyltransferase TrmD family
FYK61_RS06580	COG0335	large ribosomal subunit rRNA binding
FYK61_RS06585	COG0534	Mate efflux family protein
FYK61_RS06605	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FYK61_RS06615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FYK61_RS06625	COG3209	COG3209 Rhs family protein
FYK61_RS06640	COG4245	von Willebrand factor, type A
FYK61_RS06645	COG0631	protein serine/threonine phosphatase activity
FYK61_RS06650	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
FYK61_RS06695	COG2963	transposase activity
FYK61_RS06715	COG3250	beta-galactosidase activity
FYK61_RS06720	COG3867	Arabinogalactan endo-beta-1,4-galactanase
FYK61_RS06740	COG1960	acyl-CoA dehydrogenase activity
FYK61_RS06745	COG1024	Enoyl-CoA hydratase
FYK61_RS06785	COG1250	3-hydroxyacyl-CoA dehydrogenase
FYK61_RS06785	COG1024	Enoyl-CoA hydratase
FYK61_RS06800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FYK61_RS06805	COG0481	GTPase activity
FYK61_RS06820	COG0571	ribonuclease III activity
FYK61_RS06825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FYK61_RS06830	COG1381	Involved in DNA repair and RecF pathway recombination
FYK61_RS06840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FYK61_RS06845	COG2954	triphosphatase activity
FYK61_RS06850	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FYK61_RS06855	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FYK61_RS06860	COG3046	protein related to deoxyribodipyrimidine photolyase
FYK61_RS06865	COG1472	Belongs to the glycosyl hydrolase 3 family
FYK61_RS06870	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FYK61_RS06875	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FYK61_RS06880	COG1278	Cold shock
FYK61_RS06885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FYK61_RS06895	COG1201	RNA secondary structure unwinding
FYK61_RS06900	COG1793	dna ligase
FYK61_RS06910	COG1793	dna ligase
FYK61_RS06910	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FYK61_RS06940	COG0183	Belongs to the thiolase family
FYK61_RS06960	COG1451	nucleotide metabolic process
FYK61_RS06965	COG5487	UPF0391 membrane protein
FYK61_RS06975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FYK61_RS06995	COG1077	Cell shape determining protein MreB Mrl
FYK61_RS07000	COG1047	Peptidyl-prolyl cis-trans
FYK61_RS07010	COG2824	Alkylphosphonate utilization operon protein PhnA
FYK61_RS07015	COG1902	pentaerythritol trinitrate reductase activity
FYK61_RS07055	COG0392	lysyltransferase activity
FYK61_RS07055	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FYK61_RS07065	COG0251	oxidation-reduction process
FYK61_RS07070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FYK61_RS07085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FYK61_RS07110	COG1595	DNA-templated transcription, initiation
FYK61_RS07125	COG2878	Part of a membrane complex involved in electron transport
FYK61_RS07135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FYK61_RS07135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FYK61_RS07150	COG1131	(ABC) transporter
FYK61_RS07155	COG0346	lactoylglutathione lyase activity
FYK61_RS07160	COG0833	amino acid
FYK61_RS07165	COG2040	homocysteine
FYK61_RS07175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FYK61_RS07195	COG1695	Transcriptional regulator
FYK61_RS07215	COG1981	membrane
FYK61_RS07230	COG0825	malonyl-CoA metabolic process
FYK61_RS07245	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FYK61_RS07250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FYK61_RS07255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FYK61_RS07260	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FYK61_RS07275	COG0750	zinc metalloprotease
FYK61_RS07280	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FYK61_RS07285	COG0575	Belongs to the CDS family
FYK61_RS07290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FYK61_RS07295	COG0233	cytoplasmic translational termination
FYK61_RS07300	COG0528	UMP kinase activity
FYK61_RS07310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FYK61_RS07315	COG0052	Belongs to the universal ribosomal protein uS2 family
FYK61_RS07355	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FYK61_RS07365	COG1393	Belongs to the ArsC family
FYK61_RS07370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FYK61_RS07375	COG0367	asparagine synthase
FYK61_RS07385	COG4774	siderophore transport
FYK61_RS07400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FYK61_RS07425	COG1566	PFAM secretion protein HlyD family protein
FYK61_RS07430	COG2814	Major facilitator Superfamily
FYK61_RS07480	COG0339	signal peptide processing
FYK61_RS07485	COG0386	Belongs to the glutathione peroxidase family
FYK61_RS07540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FYK61_RS07545	COG0084	hydrolase, TatD family'
FYK61_RS07560	COG1960	acyl-CoA dehydrogenase activity
FYK61_RS07575	COG0367	asparagine synthase
FYK61_RS07585	COG0305	Participates in initiation and elongation during chromosome replication
FYK61_RS07590	COG0415	Belongs to the DNA photolyase family
FYK61_RS07600	COG0583	DNA-binding transcription factor activity
FYK61_RS07645	COG3706	GGDEF domain
FYK61_RS07665	COG0546	phosphoglycolate phosphatase activity
FYK61_RS07670	COG0758	DNA mediated transformation
FYK61_RS07770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FYK61_RS07785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FYK61_RS07795	COG0497	DNA recombination
FYK61_RS07800	COG1420	regulation of RNA biosynthetic process
FYK61_RS07805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FYK61_RS07810	COG0443	Heat shock 70 kDa protein
FYK61_RS07815	COG0484	heat shock protein binding
FYK61_RS07820	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FYK61_RS07850	COG0583	DNA-binding transcription factor activity
FYK61_RS07855	COG1132	(ABC) transporter
FYK61_RS07880	COG0567	Dehydrogenase, E1 component
FYK61_RS07890	COG2850	peptidyl-arginine hydroxylation
FYK61_RS07910	COG1253	flavin adenine dinucleotide binding
FYK61_RS07940	COG1131	(ABC) transporter
FYK61_RS07945	COG1725	Transcriptional regulator
FYK61_RS07955	COG0386	Belongs to the glutathione peroxidase family
FYK61_RS07970	COG2900	Belongs to the SlyX family
FYK61_RS07995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FYK61_RS08005	COG0646	methionine synthase
FYK61_RS08005	COG1410	methionine synthase
FYK61_RS08010	COG0646	methionine synthase
FYK61_RS08010	COG1410	methionine synthase
FYK61_RS08015	COG2226	methyltransferase
FYK61_RS08020	COG1960	acyl-CoA dehydrogenase activity
FYK61_RS08025	COG1960	acyl-CoA dehydrogenase activity
FYK61_RS08055	COG0557	exoribonuclease II activity
FYK61_RS08065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FYK61_RS08075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FYK61_RS08085	COG0704	Plays a role in the regulation of phosphate uptake
FYK61_RS08090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FYK61_RS08095	COG0581	inorganic phosphate transmembrane transporter activity
FYK61_RS08100	COG0573	inorganic phosphate transmembrane transporter activity
FYK61_RS08105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FYK61_RS08130	COG0659	secondary active sulfate transmembrane transporter activity
FYK61_RS08135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FYK61_RS08145	COG1024	Enoyl-CoA hydratase
FYK61_RS08155	COG0494	nUDIX hydrolase
FYK61_RS08200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FYK61_RS08200	COG0116	Belongs to the methyltransferase superfamily
FYK61_RS08205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FYK61_RS08230	COG2925	Exonuclease
FYK61_RS08235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FYK61_RS08240	COG3844	kynureninase activity
FYK61_RS08250	COG0662	Cupin 2, conserved barrel domain protein
FYK61_RS08255	COG0288	reversible hydration of carbon dioxide
FYK61_RS08335	COG0017	Asparaginyl-tRNA synthetase
FYK61_RS08340	COG0316	Belongs to the HesB IscA family
FYK61_RS08345	COG0360	Binds together with S18 to 16S ribosomal RNA
FYK61_RS08350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FYK61_RS08355	COG0359	binds to the 23S rRNA
FYK61_RS08370	COG3115	cell septum assembly
FYK61_RS08380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FYK61_RS08385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FYK61_RS08390	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FYK61_RS08400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FYK61_RS08410	COG4993	Dehydrogenase
FYK61_RS08420	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FYK61_RS08430	COG2986	histidine ammonia-lyase
FYK61_RS08435	COG1228	amidohydrolase
FYK61_RS08470	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FYK61_RS08475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FYK61_RS08480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FYK61_RS08485	COG0077	Prephenate dehydratase
FYK61_RS08485	COG1605	Chorismate mutase
FYK61_RS08490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FYK61_RS08505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FYK61_RS08510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FYK61_RS08515	COG0583	DNA-binding transcription factor activity
FYK61_RS08530	COG0840	transmembrane signaling receptor activity
FYK61_RS08555	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FYK61_RS08560	COG4191	Histidine kinase
FYK61_RS08560	COG0784	Response regulator, receiver
FYK61_RS08575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FYK61_RS08585	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FYK61_RS08595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FYK61_RS08610	COG1595	DNA-templated transcription, initiation
FYK61_RS08660	COG2244	polysaccharide biosynthetic process
FYK61_RS08690	COG2264	protein methyltransferase activity
FYK61_RS08715	COG1136	(ABC) transporter
FYK61_RS08725	COG0477	Major facilitator Superfamily
FYK61_RS08730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FYK61_RS08745	COG1253	flavin adenine dinucleotide binding
FYK61_RS08755	COG0306	phosphate transporter
FYK61_RS08780	COG0504	CTP synthase activity
FYK61_RS08795	COG0148	phosphopyruvate hydratase activity
FYK61_RS08800	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FYK61_RS08805	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FYK61_RS08810	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FYK61_RS08815	COG0585	pseudouridine synthase activity
FYK61_RS08820	COG2840	Smr protein MutS2
FYK61_RS08825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FYK61_RS08830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FYK61_RS08835	COG1238	metal cluster binding
FYK61_RS08850	COG1534	Rna-binding protein
FYK61_RS08855	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FYK61_RS08865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FYK61_RS08870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FYK61_RS08880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FYK61_RS08885	COG1546	Belongs to the CinA family
FYK61_RS08895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FYK61_RS08900	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FYK61_RS08905	COG2137	regulation of response to DNA damage stimulus
FYK61_RS08910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FYK61_RS08915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FYK61_RS08930	COG1741	Belongs to the pirin family
FYK61_RS08935	COG0583	DNA-binding transcription factor activity
FYK61_RS08960	COG0351	phosphomethylpyrimidine kinase
FYK61_RS08975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FYK61_RS08980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FYK61_RS08995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FYK61_RS09005	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FYK61_RS09010	COG3734	2-keto-3-deoxy-galactonokinase
FYK61_RS09020	COG4948	Mandelate Racemase Muconate Lactonizing
FYK61_RS09025	COG0800	Aldolase
FYK61_RS09060	COG1501	Belongs to the glycosyl hydrolase 31 family
FYK61_RS09070	COG1070	Carbohydrate kinase
FYK61_RS09075	COG2115	Belongs to the xylose isomerase family
FYK61_RS09080	COG0477	Major facilitator Superfamily
FYK61_RS09095	COG0860	N-Acetylmuramoyl-L-alanine amidase
FYK61_RS09100	COG1469	GTP cyclohydrolase I activity
FYK61_RS09110	COG0617	tRNA 3'-terminal CCA addition
FYK61_RS09120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FYK61_RS09125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FYK61_RS09130	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FYK61_RS09155	COG1472	Belongs to the glycosyl hydrolase 3 family
FYK61_RS09165	COG5001	Diguanylate cyclase
FYK61_RS09165	COG2203	Gaf domain
FYK61_RS09165	COG3706	GGDEF domain
FYK61_RS09165	COG4251	negative regulation of phosphorylation
FYK61_RS09170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FYK61_RS09175	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FYK61_RS09185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FYK61_RS09190	COG0671	phosphoesterase, PA-phosphatase related
FYK61_RS09205	COG1794	racemase activity, acting on amino acids and derivatives
FYK61_RS09210	COG0697	spore germination
FYK61_RS09215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FYK61_RS09220	COG0167	dihydroorotate dehydrogenase activity
FYK61_RS09240	COG1012	belongs to the aldehyde dehydrogenase family
FYK61_RS09275	COG1215	transferase activity, transferring glycosyl groups
FYK61_RS09280	COG1649	PFAM Uncharacterised BCR, COG1649
FYK61_RS09280	COG0726	polysaccharide deacetylase
FYK61_RS09375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FYK61_RS09380	COG0124	histidyl-tRNA synthetase
FYK61_RS09390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FYK61_RS09395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FYK61_RS09400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FYK61_RS09405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FYK61_RS09405	COG0131	Imidazoleglycerol-phosphate dehydratase
FYK61_RS09410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FYK61_RS09415	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FYK61_RS09420	COG0107	imidazoleglycerol-phosphate synthase activity
FYK61_RS09425	COG0140	phosphoribosyl-ATP diphosphatase activity
FYK61_RS09425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FYK61_RS09440	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FYK61_RS09445	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FYK61_RS09450	COG0235	Class ii aldolase
FYK61_RS09455	COG0531	amino acid
FYK61_RS09460	COG0531	amino acid
FYK61_RS09470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FYK61_RS09475	COG0277	FAD linked oxidase domain protein
FYK61_RS09495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FYK61_RS09540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FYK61_RS09545	COG2258	MOSC domain
FYK61_RS09550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FYK61_RS09555	COG0505	Belongs to the CarA family
FYK61_RS09565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FYK61_RS09570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FYK61_RS09580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FYK61_RS09640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FYK61_RS09650	COG2198	Histidine kinase
FYK61_RS09650	COG2205	protein histidine kinase activity
FYK61_RS09650	COG0784	Response regulator, receiver
FYK61_RS09655	COG2205	protein histidine kinase activity
FYK61_RS09655	COG2198	Histidine kinase
FYK61_RS09655	COG0784	Response regulator, receiver
FYK61_RS09660	COG1024	Enoyl-CoA hydratase
FYK61_RS09665	COG0318	PFAM AMP-dependent synthetase and ligase
FYK61_RS09675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FYK61_RS09700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FYK61_RS09710	COG2201	protein-glutamate methylesterase activity
FYK61_RS09715	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FYK61_RS09725	COG0840	transmembrane signaling receptor activity
FYK61_RS09740	COG0835	chemotaxis
FYK61_RS09760	COG0840	transmembrane signaling receptor activity
FYK61_RS09765	COG0840	transmembrane signaling receptor activity
FYK61_RS09775	COG0840	transmembrane signaling receptor activity
FYK61_RS09785	COG0840	transmembrane signaling receptor activity
FYK61_RS09790	COG0840	transmembrane signaling receptor activity
FYK61_RS09795	COG0840	transmembrane signaling receptor activity
FYK61_RS09800	COG0840	transmembrane signaling receptor activity
FYK61_RS09810	COG0840	transmembrane signaling receptor activity
FYK61_RS09835	COG0745	RESPONSE REGULATOR receiver
FYK61_RS09845	COG0835	chemotaxis
FYK61_RS09855	COG1360	Flagellar Motor Protein
FYK61_RS09860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FYK61_RS09910	COG2198	Histidine kinase
FYK61_RS09910	COG0784	Response regulator, receiver
FYK61_RS09910	COG0643	Histidine kinase
FYK61_RS09940	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FYK61_RS09965	COG1684	flagellar biosynthetic protein fliR
FYK61_RS09980	COG3190	flagellar
FYK61_RS10030	COG1677	Flagellar hook-basal body complex protein FliE
FYK61_RS10080	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS10085	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS10090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FYK61_RS10110	COG2201	protein-glutamate methylesterase activity
FYK61_RS10140	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FYK61_RS10150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FYK61_RS10155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FYK61_RS10165	COG1705	Flagellar rod assembly protein muramidase FlgJ
FYK61_RS10165	COG3951	Flagellar rod assembly protein muramidase FlgJ
FYK61_RS10170	COG1706	bacterial-type flagellum-dependent cell motility
FYK61_RS10175	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FYK61_RS10185	COG4787	bacterial-type flagellum-dependent cell motility
FYK61_RS10195	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FYK61_RS10200	COG1558	bacterial-type flagellum-dependent cell motility
FYK61_RS10210	COG0835	chemotaxis
FYK61_RS10210	COG0784	Response regulator, receiver
FYK61_RS10230	COG5002	protein histidine kinase activity
FYK61_RS10260	COG2915	High frequency lysogenization protein hflD homolog
FYK61_RS10265	COG0482	sulfurtransferase activity
FYK61_RS10280	COG0542	response to heat
FYK61_RS10290	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FYK61_RS10300	COG0492	ferredoxin-NADP+ reductase activity
FYK61_RS10305	COG1674	ftsk spoiiie
FYK61_RS10315	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FYK61_RS10325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FYK61_RS10330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FYK61_RS10335	COG0183	Belongs to the thiolase family
FYK61_RS10340	COG1024	Enoyl-CoA hydratase
FYK61_RS10340	COG1250	3-hydroxyacyl-CoA dehydrogenase
FYK61_RS10355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FYK61_RS10365	COG1426	Protein conserved in bacteria
FYK61_RS10375	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FYK61_RS10380	COG1160	GTP binding
FYK61_RS10385	COG0303	'Molybdopterin
FYK61_RS10390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FYK61_RS10435	COG0303	'Molybdopterin
FYK61_RS10440	COG0746	molybdenum cofactor guanylyltransferase activity
FYK61_RS10470	COG1914	H( )-stimulated, divalent metal cation uptake system
FYK61_RS10490	COG0668	transmembrane transport
FYK61_RS10500	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FYK61_RS10515	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS10520	COG1183	phosphatidylcholine synthase activity
FYK61_RS10530	COG3243	poly(R)-hydroxyalkanoic acid synthase
FYK61_RS10545	COG0723	plastoquinol--plastocyanin reductase activity
FYK61_RS10545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FYK61_RS10555	COG2183	response to ionizing radiation
FYK61_RS10560	COG2205	protein histidine kinase activity
FYK61_RS10560	COG0784	Response regulator, receiver
FYK61_RS10625	COG0800	Aldolase
FYK61_RS10630	COG0129	dihydroxy-acid dehydratase activity
FYK61_RS10635	COG0363	glucosamine-6-phosphate deaminase activity
FYK61_RS10640	COG0837	glucose binding
FYK61_RS10645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FYK61_RS10655	COG0354	folic acid binding
FYK61_RS10670	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FYK61_RS10685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FYK61_RS10690	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FYK61_RS10700	COG4591	ABC-type transport system involved in lipoprotein release permease component
FYK61_RS10705	COG1136	(ABC) transporter
FYK61_RS10720	COG0811	peptide transport
FYK61_RS10725	COG0848	biopolymer transport protein
FYK61_RS10730	COG1132	(ABC) transporter
FYK61_RS10735	COG1663	tetraacyldisaccharide 4'-kinase activity
FYK61_RS10740	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FYK61_RS10745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FYK61_RS10755	COG0322	excinuclease ABC activity
FYK61_RS10760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FYK61_RS10780	COG0582	viral genome integration into host DNA
FYK61_RS10800	COG2910	NAD(P)H-binding
FYK61_RS10810	COG1234	tRNA 3'-trailer cleavage
FYK61_RS10820	COG1396	sequence-specific DNA binding
FYK61_RS10825	COG0583	DNA-binding transcription factor activity
FYK61_RS10840	COG1733	regulation of RNA biosynthetic process
FYK61_RS10900	COG3608	succinylglutamate desuccinylase aspartoacylase
FYK61_RS10900	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FYK61_RS10905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FYK61_RS10910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FYK61_RS10915	COG2080	2 iron, 2 sulfur cluster binding
FYK61_RS10925	COG2133	pyrroloquinoline quinone binding
FYK61_RS10940	COG3246	L-lysine catabolic process to acetate
FYK61_RS11000	COG2003	Belongs to the UPF0758 family
FYK61_RS11225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FYK61_RS11230	COG0629	single-stranded DNA binding
FYK61_RS11285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FYK61_RS11305	COG1054	Belongs to the UPF0176 family
FYK61_RS11315	COG1530	ribonuclease E activity
FYK61_RS11325	COG3064	Membrane
FYK61_RS11330	COG0428	transporter
FYK61_RS11340	COG2154	pterin-4-alpha-carbinolamine dehydratase
FYK61_RS11345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FYK61_RS11345	COG0316	Belongs to the HesB IscA family
FYK61_RS11390	COG2226	methyltransferase
FYK61_RS11390	COG1073	alpha beta
FYK61_RS11410	COG4644	lycopene metabolic process
FYK61_RS11445	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS11555	COG1408	metallophosphoesterase
FYK61_RS11560	COG1064	alcohol dehydrogenase
FYK61_RS11565	COG0667	Aldo Keto reductase
FYK61_RS11615	COG0667	Aldo Keto reductase
FYK61_RS11665	COG4644	lycopene metabolic process
FYK61_RS11685	COG3920	Histidine kinase
FYK61_RS11695	COG1238	metal cluster binding
FYK61_RS11725	COG3279	Response regulator of the LytR AlgR family
FYK61_RS11730	COG3275	phosphorelay sensor kinase activity
FYK61_RS11765	COG4566	intracellular signal transduction
FYK61_RS11775	COG5001	Diguanylate cyclase
FYK61_RS11795	COG3685	Protein conserved in bacteria
FYK61_RS11815	COG1648	precorrin-2 dehydrogenase activity
FYK61_RS11815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FYK61_RS11830	COG2814	Major facilitator Superfamily
FYK61_RS11845	COG1335	isochorismatase
FYK61_RS11860	COG2197	response regulator
FYK61_RS11875	COG0583	DNA-binding transcription factor activity
FYK61_RS11880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FYK61_RS11885	COG3002	Belongs to the UPF0753 family
FYK61_RS11890	COG0519	Catalyzes the synthesis of GMP from XMP
FYK61_RS11890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FYK61_RS11900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FYK61_RS11910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FYK61_RS11910	COG0475	glutathione-regulated potassium exporter activity
FYK61_RS11915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FYK61_RS11925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FYK61_RS11930	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FYK61_RS11940	COG0776	regulation of translation
FYK61_RS11945	COG0539	negative regulation of cytoplasmic translation
FYK61_RS11950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FYK61_RS11965	COG2957	Belongs to the agmatine deiminase family
FYK61_RS11970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FYK61_RS11995	COG0395	ABC-type sugar transport system, permease component
FYK61_RS12000	COG1175	transmembrane transport
FYK61_RS12030	COG2350	Protein conserved in bacteria
FYK61_RS12035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FYK61_RS12040	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FYK61_RS12045	COG1187	pseudouridine synthase activity
FYK61_RS12065	COG0436	Aminotransferase
FYK61_RS12070	COG4133	protoheme IX ABC transporter activity
FYK61_RS12090	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FYK61_RS12095	COG1138	Cytochrome C-type biogenesis protein
FYK61_RS12115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FYK61_RS12120	COG1278	Cold shock
FYK61_RS12125	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FYK61_RS12130	COG4988	ABC transporter
FYK61_RS12140	COG1294	oxidase, subunit
FYK61_RS12170	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FYK61_RS12175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FYK61_RS12185	COG0165	Argininosuccinate lyase
FYK61_RS12190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FYK61_RS12200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FYK61_RS12205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FYK61_RS12215	COG0137	argininosuccinate synthase activity
FYK61_RS12220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FYK61_RS12230	COG0215	cysteine-tRNA ligase activity
FYK61_RS12235	COG2166	iron-sulfur cluster assembly
FYK61_RS12250	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FYK61_RS12255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FYK61_RS12275	COG4302	ethanolamine ammonia-lyase activity
FYK61_RS12330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FYK61_RS12335	COG0402	S-adenosylhomocysteine deaminase activity
FYK61_RS12345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FYK61_RS12350	COG1509	lysine 2,3-aminomutase activity
FYK61_RS12355	COG3300	MHYT domain
FYK61_RS12355	COG5001	Diguanylate cyclase
FYK61_RS12370	COG0483	inositol monophosphate 1-phosphatase activity
FYK61_RS12375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FYK61_RS12390	COG0488	(ABC) transporter
FYK61_RS12395	COG0513	Belongs to the DEAD box helicase family
FYK61_RS12400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FYK61_RS12405	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FYK61_RS12415	COG0625	glutathione transferase activity
FYK61_RS12425	COG4681	YaeQ
FYK61_RS12430	COG2081	HI0933 family
FYK61_RS12440	COG0501	Belongs to the peptidase M48B family
FYK61_RS12445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FYK61_RS12450	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS12475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FYK61_RS12480	COG0860	N-Acetylmuramoyl-L-alanine amidase
FYK61_RS12485	COG0802	atpase or kinase
FYK61_RS12490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FYK61_RS12490	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FYK61_RS12495	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FYK61_RS12500	COG1570	exodeoxyribonuclease VII activity
FYK61_RS12510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FYK61_RS12555	COG0835	chemotaxis
FYK61_RS12560	COG0840	transmembrane signaling receptor activity
FYK61_RS12565	COG2094	Belongs to the DNA glycosylase MPG family
FYK61_RS12570	COG1201	RNA secondary structure unwinding
FYK61_RS12590	COG2969	positive regulation of protein catabolic process
FYK61_RS12595	COG0625	glutathione transferase activity
FYK61_RS12600	COG2857	Cytochrome c1
FYK61_RS12605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FYK61_RS12610	COG0723	plastoquinol--plastocyanin reductase activity
FYK61_RS12615	COG0741	lytic transglycosylase activity
FYK61_RS12630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FYK61_RS12635	COG1702	phosphate starvation-inducible protein PhoH
FYK61_RS12645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FYK61_RS12655	COG4535	Mg2 and Co2 transporter CorC
FYK61_RS12670	COG1012	belongs to the aldehyde dehydrogenase family
FYK61_RS12675	COG1177	transmembrane transport
FYK61_RS12680	COG1176	ABC-type spermidine putrescine transport system, permease component I
FYK61_RS12690	COG3842	ATPase activity
FYK61_RS12710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FYK61_RS12725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FYK61_RS12730	COG0174	glutamine synthetase
FYK61_RS12735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FYK61_RS12745	COG2703	oxygen carrier activity
FYK61_RS12750	COG0477	Major facilitator Superfamily
FYK61_RS12760	COG0243	molybdopterin cofactor binding
FYK61_RS12765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FYK61_RS12770	COG2223	nitrite transmembrane transporter activity
FYK61_RS12775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FYK61_RS12785	COG2733	membrane
FYK61_RS12790	COG0784	Response regulator, receiver
FYK61_RS12790	COG2205	protein histidine kinase activity
FYK61_RS12790	COG5002	protein histidine kinase activity
FYK61_RS12805	COG0477	Major facilitator Superfamily
FYK61_RS12835	COG2902	Dehydrogenase
FYK61_RS12845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FYK61_RS12850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FYK61_RS12855	COG1609	Transcriptional regulator
FYK61_RS12860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FYK61_RS12860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FYK61_RS12865	COG1105	Belongs to the carbohydrate kinase PfkB family
FYK61_RS12870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FYK61_RS12870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FYK61_RS12890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FYK61_RS12900	COG1862	Preprotein translocase
FYK61_RS12905	COG0343	queuine tRNA-ribosyltransferase activity
FYK61_RS12910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FYK61_RS12965	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FYK61_RS12970	COG3291	Pkd domain containing protein
FYK61_RS12975	COG0405	Gamma-glutamyltransferase
FYK61_RS12980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FYK61_RS12990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FYK61_RS12995	COG0742	ribosomal rna small subunit methyltransferase
FYK61_RS13000	COG0326	Molecular chaperone. Has ATPase activity
FYK61_RS13095	COG0531	amino acid
FYK61_RS13110	COG0006	proline dipeptidase activity
FYK61_RS13120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FYK61_RS13135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FYK61_RS13140	COG3938	Belongs to the proline racemase family
FYK61_RS13150	COG0552	protein localization to endoplasmic reticulum
FYK61_RS13155	COG1194	a g-specific adenine glycosylase
FYK61_RS13160	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FYK61_RS13165	COG4191	Histidine kinase
FYK61_RS13165	COG0784	Response regulator, receiver
FYK61_RS13180	COG0322	excinuclease ABC activity
FYK61_RS13195	COG3040	lipid binding
FYK61_RS13205	COG1960	acyl-CoA dehydrogenase activity
FYK61_RS13215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FYK61_RS13235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FYK61_RS13240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FYK61_RS13245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FYK61_RS13270	COG0438	transferase activity, transferring glycosyl groups
FYK61_RS13280	COG0438	transferase activity, transferring glycosyl groups
FYK61_RS13285	COG0438	transferase activity, transferring glycosyl groups
FYK61_RS13335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FYK61_RS13335	COG0072	phenylalanine-tRNA ligase activity
FYK61_RS13340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FYK61_RS13355	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FYK61_RS13360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FYK61_RS13375	COG2211	Major facilitator Superfamily
FYK61_RS13375	COG2190	(PTS) system
FYK61_RS13385	COG1082	Xylose isomerase domain protein TIM barrel
FYK61_RS13400	COG0366	Alpha amylase catalytic
FYK61_RS13480	COG3702	type iv secretory pathway
FYK61_RS13500	COG2948	multi-organism process
FYK61_RS13520	COG3505	Type IV secretory pathway VirD4
FYK61_RS13535	COG0556	nucleotide-excision repair
FYK61_RS13540	COG4969	Belongs to the N-Me-Phe pilin family
FYK61_RS13580	COG1611	Belongs to the LOG family
FYK61_RS13590	COG2095	MarC family integral membrane protein
FYK61_RS13600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FYK61_RS13635	COG1185	polyribonucleotide nucleotidyltransferase activity
FYK61_RS13640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FYK61_RS13645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FYK61_RS13650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FYK61_RS13655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FYK61_RS13660	COG0195	Participates in both transcription termination and antitermination
FYK61_RS13665	COG0779	Required for maturation of 30S ribosomal subunits
FYK61_RS13675	COG1007	ATP synthesis coupled electron transport
FYK61_RS13700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FYK61_RS13705	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FYK61_RS13715	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FYK61_RS13720	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FYK61_RS13725	COG0649	NAD binding
FYK61_RS13730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FYK61_RS13735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FYK61_RS13740	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FYK61_RS13755	COG0149	triose-phosphate isomerase activity
FYK61_RS13760	COG0300	oxidoreductase activity
FYK61_RS13790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FYK61_RS13795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FYK61_RS13800	COG0159	tryptophan synthase activity
FYK61_RS13810	COG0133	tryptophan synthase activity
FYK61_RS13820	COG0135	phosphoribosylanthranilate isomerase activity
FYK61_RS13825	COG0101	tRNA pseudouridine synthase activity
FYK61_RS13840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FYK61_RS13845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FYK61_RS13850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FYK61_RS13855	COG2890	protein-(glutamine-N5) methyltransferase activity
FYK61_RS13865	COG0688	phosphatidylethanolamine metabolic process
FYK61_RS13875	COG0433	COG0433 Predicted ATPase
FYK61_RS13880	COG0494	nUDIX hydrolase
FYK61_RS13895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FYK61_RS13900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FYK61_RS13925	COG0717	Belongs to the dCTP deaminase family
FYK61_RS13930	COG0489	protein tyrosine kinase activity
FYK61_RS13950	COG3590	peptidase
FYK61_RS13955	COG3590	peptidase
FYK61_RS13975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FYK61_RS13980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FYK61_RS13985	COG2311	Membrane
FYK61_RS13990	COG1047	Peptidyl-prolyl cis-trans
FYK61_RS13995	COG0791	NLP P60 protein
FYK61_RS14000	COG0791	NLP P60 protein
FYK61_RS14010	COG4106	trans-aconitate 2-methyltransferase activity
FYK61_RS14015	COG1301	dicarboxylic acid transport
FYK61_RS14020	COG1785	Belongs to the alkaline phosphatase family
FYK61_RS14025	COG0037	tRNA processing
FYK61_RS14030	COG1722	exodeoxyribonuclease VII activity
FYK61_RS14035	COG0142	geranyltranstransferase activity
FYK61_RS14040	COG4104	PAAR repeat-containing protein
FYK61_RS14050	COG0312	modulator of DNA gyrase
FYK61_RS14055	COG3028	Belongs to the UPF0307 family
FYK61_RS14060	COG0312	modulator of DNA gyrase
FYK61_RS14070	COG3164	Protein of unknown function
FYK61_RS14080	COG0424	maF-like protein
FYK61_RS14085	COG2968	Membrane
FYK61_RS14100	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FYK61_RS14115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FYK61_RS14130	COG0495	leucyl-tRNA aminoacylation
FYK61_RS14140	COG3118	belongs to the thioredoxin family
FYK61_RS14185	COG2155	Conserved Protein
FYK61_RS14230	COG1132	(ABC) transporter
FYK61_RS14255	COG1538	Outer membrane efflux protein
FYK61_RS14260	COG0745	RESPONSE REGULATOR receiver
FYK61_RS14265	COG5000	phosphorelay sensor kinase activity
FYK61_RS14265	COG5002	protein histidine kinase activity
FYK61_RS14270	COG0475	glutathione-regulated potassium exporter activity
FYK61_RS14280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FYK61_RS14300	COG1187	pseudouridine synthase activity
FYK61_RS14305	COG5002	protein histidine kinase activity
FYK61_RS14305	COG5001	Diguanylate cyclase
FYK61_RS14315	COG1595	DNA-templated transcription, initiation
FYK61_RS14415	COG0667	Aldo Keto reductase
FYK61_RS14420	COG2814	Major facilitator Superfamily
FYK61_RS14445	COG1309	transcriptional regulator
FYK61_RS14455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FYK61_RS14470	COG0735	belongs to the Fur family
FYK61_RS14475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FYK61_RS14500	COG4452	Inner membrane protein CreD
FYK61_RS14510	COG2205	protein histidine kinase activity
FYK61_RS14515	COG0745	RESPONSE REGULATOR receiver
FYK61_RS14520	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FYK61_RS14530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FYK61_RS14540	COG2198	Histidine kinase
FYK61_RS14540	COG0643	Histidine kinase
FYK61_RS14545	COG0840	transmembrane signaling receptor activity
FYK61_RS14550	COG0835	chemotaxis
FYK61_RS14555	COG2199	diguanylate cyclase activity
FYK61_RS14555	COG2200	EAL domain
FYK61_RS14555	COG2202	Pas domain
FYK61_RS14560	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FYK61_RS14565	COG2201	protein-glutamate methylesterase activity
FYK61_RS14570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FYK61_RS14575	COG3590	peptidase
FYK61_RS14585	COG0588	phosphoglycerate mutase activity
FYK61_RS14590	COG1515	deoxyribonuclease V activity
FYK61_RS14615	COG1741	Belongs to the pirin family
FYK61_RS14620	COG1966	Carbon starvation protein
FYK61_RS14625	COG2879	small protein
FYK61_RS14660	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FYK61_RS14665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FYK61_RS14670	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FYK61_RS14675	COG2080	2 iron, 2 sulfur cluster binding
FYK61_RS14680	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS14680	COG0604	alcohol dehydrogenase
FYK61_RS14680	COG3321	synthase
FYK61_RS14685	COG2203	Gaf domain
FYK61_RS14685	COG5001	Diguanylate cyclase
FYK61_RS14685	COG3706	GGDEF domain
FYK61_RS14685	COG4251	negative regulation of phosphorylation
FYK61_RS14690	COG0629	single-stranded DNA binding
FYK61_RS14695	COG0142	geranyltranstransferase activity
FYK61_RS14710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FYK61_RS14725	COG0527	aspartate kinase activity
FYK61_RS14730	COG0384	phenazine biosynthesis protein PhzF
FYK61_RS14735	COG0384	phenazine biosynthesis protein PhzF
FYK61_RS14745	COG1764	response to oxidative stress
FYK61_RS14750	COG0540	Belongs to the ATCase OTCase family
FYK61_RS14755	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FYK61_RS14760	COG1678	Uncharacterized ACR, COG1678
FYK61_RS14765	COG0519	Catalyzes the synthesis of GMP from XMP
FYK61_RS14790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FYK61_RS14805	COG0739	heme binding
FYK61_RS14825	COG0693	protein deglycase activity
FYK61_RS14835	COG1959	2 iron, 2 sulfur cluster binding
FYK61_RS14840	COG0719	Fe-S assembly protein
FYK61_RS14845	COG0396	ATPase activity
FYK61_RS14850	COG0719	Fe-S assembly protein
FYK61_RS14855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FYK61_RS14865	COG2146	nitrite reductase [NAD(P)H] activity
FYK61_RS14875	COG3128	pkhd-type hydroxylase
FYK61_RS14900	COG1477	protein flavinylation
FYK61_RS14905	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FYK61_RS14915	COG1555	photosystem II stabilization
FYK61_RS14930	COG3178	'Phosphotransferase
FYK61_RS14935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FYK61_RS14945	COG0628	permease
FYK61_RS14955	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FYK61_RS14965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FYK61_RS14985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FYK61_RS14990	COG0271	Belongs to the BolA IbaG family
FYK61_RS15000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FYK61_RS15010	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FYK61_RS15015	COG1137	ATPase activity
FYK61_RS15030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FYK61_RS15035	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FYK61_RS15040	COG1660	Displays ATPase and GTPase activities
FYK61_RS15050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FYK61_RS15055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FYK61_RS15060	COG2239	Acts as a magnesium transporter
FYK61_RS15070	COG1294	oxidase, subunit
FYK61_RS15075	COG1271	oxidase subunit
FYK61_RS15085	COG1113	amino acid transport
FYK61_RS15100	COG2197	response regulator
FYK61_RS15105	COG0531	amino acid
FYK61_RS15170	COG2814	Major facilitator Superfamily
FYK61_RS15180	COG0754	glutathionylspermidine amidase activity
FYK61_RS15205	COG1842	Phage shock protein A
FYK61_RS15215	COG0259	pyridoxamine-phosphate oxidase activity
FYK61_RS15220	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FYK61_RS15225	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FYK61_RS15235	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FYK61_RS15240	COG2814	Major facilitator Superfamily
FYK61_RS15260	COG0784	Response regulator, receiver
FYK61_RS15260	COG2198	Histidine kinase
FYK61_RS15260	COG2205	protein histidine kinase activity
FYK61_RS15265	COG2353	YceI-like domain
FYK61_RS15285	COG1760	l-serine dehydratase
FYK61_RS15295	COG0460	homoserine dehydrogenase
FYK61_RS15295	COG0527	aspartate kinase activity
FYK61_RS15300	COG0626	cystathionine gamma-synthase activity
FYK61_RS15305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FYK61_RS15310	COG0739	heme binding
FYK61_RS15315	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FYK61_RS15320	COG1272	protein, Hemolysin III
FYK61_RS15325	COG2982	Protein involved in outer membrane biogenesis
FYK61_RS15330	COG0516	GMP reductase activity
FYK61_RS15330	COG0517	IMP dehydrogenase activity
FYK61_RS15335	COG0463	Glycosyl transferase, family 2
FYK61_RS15340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FYK61_RS15345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FYK61_RS15355	COG4771	TonB-dependent receptor
FYK61_RS15365	COG1309	transcriptional regulator
FYK61_RS15375	COG1960	acyl-CoA dehydrogenase activity
FYK61_RS15405	COG0509	glycine decarboxylation via glycine cleavage system
FYK61_RS15410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FYK61_RS15430	COG1742	UPF0060 membrane protein
FYK61_RS15435	COG3956	TIGRFAM MazG family protein
FYK61_RS15440	COG1218	3'(2'),5'-bisphosphate nucleotidase
FYK61_RS15445	COG0494	nUDIX hydrolase
FYK61_RS15455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FYK61_RS15460	COG0837	glucose binding
FYK61_RS15475	COG3858	chitin binding
FYK61_RS15475	COG1388	LysM domain
FYK61_RS15480	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FYK61_RS15490	COG1472	Belongs to the glycosyl hydrolase 3 family
FYK61_RS15505	COG0531	amino acid
FYK61_RS15515	COG1486	melibiose metabolic process
FYK61_RS15525	COG3537	Alpha-1,2-mannosidase
FYK61_RS15560	COG3142	Participates in the control of copper homeostasis
FYK61_RS15565	COG1446	asparaginase
FYK61_RS15585	COG2198	Histidine kinase
FYK61_RS15585	COG0643	Histidine kinase
FYK61_RS15585	COG0784	Response regulator, receiver
FYK61_RS15590	COG0840	transmembrane signaling receptor activity
FYK61_RS15595	COG0835	chemotaxis
FYK61_RS15610	COG0189	ligase activity
FYK61_RS15620	COG1397	ADP-ribosylglycohydrolase
FYK61_RS15630	COG1199	ATP-dependent helicase activity
FYK61_RS15640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FYK61_RS15645	COG1216	Glycosyl transferase, family 2
FYK61_RS15645	COG1442	glycosyl transferase family 8
FYK61_RS15655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FYK61_RS15665	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FYK61_RS15670	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FYK61_RS15675	COG0535	radical SAM domain protein
FYK61_RS15680	COG0535	radical SAM domain protein
FYK61_RS15695	COG0837	glucose binding
FYK61_RS15705	COG1643	Atp-dependent helicase
FYK61_RS15710	COG0783	Belongs to the Dps family
FYK61_RS15715	COG0514	ATP-dependent DNA helicase (RecQ)
FYK61_RS15750	COG0840	transmembrane signaling receptor activity
FYK61_RS15770	COG3920	Histidine kinase
FYK61_RS15775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FYK61_RS15785	COG0602	queuosine metabolic process
FYK61_RS15795	COG2885	chlorophyll binding
FYK61_RS15800	COG0823	Involved in the tonB-independent uptake of proteins
FYK61_RS15810	COG0848	biopolymer transport protein
FYK61_RS15820	COG0824	Thioesterase
FYK61_RS15825	COG2255	four-way junction helicase activity
FYK61_RS15830	COG3158	transport of potassium into the cell
FYK61_RS15835	COG0632	four-way junction helicase activity
FYK61_RS15840	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FYK61_RS15845	COG0217	transcriptional regulatory protein
FYK61_RS15860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FYK61_RS15875	COG0477	Major facilitator Superfamily
FYK61_RS15915	COG0488	(ABC) transporter
FYK61_RS15945	COG4651	solute:proton antiporter activity
FYK61_RS15945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FYK61_RS15955	COG4772	TonB-dependent receptor
FYK61_RS15965	COG4264	IucA IucC family
FYK61_RS15980	COG0019	diaminopimelate decarboxylase activity
FYK61_RS16010	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FYK61_RS16020	COG1492	cobalamin metabolic process
FYK61_RS16030	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FYK61_RS16055	COG4206	TonB-dependent receptor
FYK61_RS16060	COG0542	response to heat
FYK61_RS16065	COG1116	anion transmembrane transporter activity
FYK61_RS16070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FYK61_RS16075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FYK61_RS16080	COG0667	Aldo Keto reductase
FYK61_RS16085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FYK61_RS16090	COG4771	TonB-dependent receptor
FYK61_RS16095	COG2827	Endonuclease containing a URI domain
FYK61_RS16135	COG1877	trehalose-phosphatase activity
FYK61_RS16140	COG3387	PFAM Glycoside hydrolase 15-related
FYK61_RS16155	COG0840	transmembrane signaling receptor activity
FYK61_RS16160	COG3011	Protein conserved in bacteria
FYK61_RS16175	COG0564	pseudouridine synthase activity
FYK61_RS16180	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FYK61_RS16190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FYK61_RS16190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FYK61_RS16205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FYK61_RS16210	COG0045	succinate-CoA ligase (ADP-forming) activity
FYK61_RS16230	COG4969	Belongs to the N-Me-Phe pilin family
FYK61_RS16245	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FYK61_RS16250	COG0237	dephospho-CoA kinase activity
FYK61_RS16270	COG0745	RESPONSE REGULATOR receiver
FYK61_RS16280	COG0189	ligase activity
FYK61_RS16320	COG2022	thiamine diphosphate biosynthetic process
FYK61_RS16325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FYK61_RS16330	COG3273	potassium ion transport
FYK61_RS16330	COG0471	metal ion transport
FYK61_RS16350	COG1970	mechanosensitive ion channel activity
FYK61_RS16360	COG1609	Transcriptional regulator
FYK61_RS16370	COG3250	beta-galactosidase activity
FYK61_RS16375	COG4948	Mandelate Racemase Muconate Lactonizing
FYK61_RS16390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FYK61_RS16400	COG0308	aminopeptidase N
FYK61_RS16430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FYK61_RS16440	COG0529	Catalyzes the synthesis of activated sulfate
FYK61_RS16440	COG2895	sulfate adenylyltransferase (ATP) activity
FYK61_RS16445	COG0175	sulfate reduction
FYK61_RS16450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FYK61_RS16455	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FYK61_RS16460	COG0175	sulfate reduction
FYK61_RS16470	COG4774	siderophore transport
FYK61_RS16480	COG2205	protein histidine kinase activity
FYK61_RS16480	COG0784	Response regulator, receiver
FYK61_RS16480	COG2198	Histidine kinase
FYK61_RS16510	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FYK61_RS16515	COG3588	fructose-bisphosphate aldolase
FYK61_RS16520	COG0469	pyruvate kinase activity
FYK61_RS16530	COG0126	phosphoglycerate kinase activity
FYK61_RS16550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FYK61_RS16560	COG3047	cAMP biosynthetic process
FYK61_RS16565	COG3047	cAMP biosynthetic process
FYK61_RS16575	COG3453	Protein conserved in bacteria
FYK61_RS16575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FYK61_RS16580	COG0725	ABC transporter, periplasmic molybdate-binding protein
FYK61_RS16585	COG4149	molybdate abc transporter
FYK61_RS16590	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FYK61_RS16625	COG1376	ErfK ybiS ycfS ynhG family protein
FYK61_RS16630	COG0739	heme binding
FYK61_RS16635	COG4773	Receptor
FYK61_RS16640	COG0596	Alpha beta hydrolase
FYK61_RS16645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FYK61_RS16650	COG1301	dicarboxylic acid transport
FYK61_RS16660	COG2304	oxidoreductase activity
FYK61_RS16680	COG0714	Associated with various cellular activities
FYK61_RS16710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FYK61_RS16735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FYK61_RS16745	COG2721	sulfolactate sulfo-lyase activity
FYK61_RS16760	COG2271	Major facilitator Superfamily
FYK61_RS16775	COG0583	DNA-binding transcription factor activity
FYK61_RS16780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FYK61_RS16795	COG1561	YicC-like family, N-terminal region
FYK61_RS16800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FYK61_RS16810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FYK61_RS16815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FYK61_RS16830	COG0006	proline dipeptidase activity
FYK61_RS16840	COG0006	proline dipeptidase activity
FYK61_RS16845	COG3079	Belongs to the UPF0149 family
FYK61_RS16865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FYK61_RS16875	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FYK61_RS16885	COG2912	Transglutaminase-like superfamily
FYK61_RS16890	COG1773	rubredoxin
FYK61_RS16895	COG0352	thiamine-phosphate diphosphorylase activity
FYK61_RS16910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FYK61_RS16925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FYK61_RS16955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FYK61_RS16960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FYK61_RS16965	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS16975	COG0671	phosphoesterase, PA-phosphatase related
FYK61_RS16980	COG3781	membrane
FYK61_RS16990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FYK61_RS16995	COG0563	adenylate kinase activity
FYK61_RS17010	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FYK61_RS17020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FYK61_RS17040	COG3710	Transcriptional regulator
FYK61_RS17045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FYK61_RS17055	COG0840	transmembrane signaling receptor activity
FYK61_RS17060	COG0405	Gamma-glutamyltransferase
FYK61_RS17065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FYK61_RS17085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FYK61_RS17090	COG0473	3-isopropylmalate dehydrogenase activity
FYK61_RS17095	COG0066	3-isopropylmalate dehydratase activity
FYK61_RS17100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FYK61_RS17120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FYK61_RS17125	COG1538	Outer membrane efflux protein
FYK61_RS17130	COG1519	Transferase
FYK61_RS17135	COG1560	Kdo2-lipid A biosynthetic process
FYK61_RS17190	COG0280	phosphate acetyltransferase
FYK61_RS17190	COG0281	malic enzyme
FYK61_RS17195	COG1301	dicarboxylic acid transport
FYK61_RS17220	COG0583	DNA-binding transcription factor activity
FYK61_RS17225	COG0667	Aldo Keto reductase
FYK61_RS17240	COG2197	response regulator
FYK61_RS17250	COG0642	Histidine kinase
FYK61_RS17265	COG2851	Citrate transporter
FYK61_RS17270	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS17275	COG1609	Transcriptional regulator
FYK61_RS17280	COG2211	Major facilitator Superfamily
FYK61_RS17310	COG1162	GTPase activity
FYK61_RS17345	COG0436	Aminotransferase
FYK61_RS17360	COG0726	polysaccharide deacetylase
FYK61_RS17365	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FYK61_RS17380	COG3964	amidohydrolase
FYK61_RS17385	COG0402	S-adenosylhomocysteine deaminase activity
FYK61_RS17405	COG1307	EDD domain protein, DegV family
FYK61_RS17410	COG0242	peptide deformylase activity
FYK61_RS17430	COG0457	Tetratricopeptide repeat
FYK61_RS17435	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FYK61_RS17440	COG1215	transferase activity, transferring glycosyl groups
FYK61_RS17445	COG1215	transferase activity, transferring glycosyl groups
FYK61_RS17460	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FYK61_RS17505	COG2188	Transcriptional regulator
FYK61_RS17515	COG1450	Type ii and iii secretion system protein
FYK61_RS17530	COG3166	PFAM Fimbrial assembly family protein
FYK61_RS17535	COG3156	type II secretion system protein K
FYK61_RS17540	COG4795	General secretion pathway protein
FYK61_RS17545	COG2165	general secretion pathway protein
FYK61_RS17550	COG4970	Tfp pilus assembly protein FimT
FYK61_RS17555	COG2165	general secretion pathway protein
FYK61_RS17560	COG1459	type II secretion system
FYK61_RS17565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FYK61_RS17570	COG1404	Belongs to the peptidase S8 family
FYK61_RS17575	COG5295	Hep Hag repeat protein
FYK61_RS17580	COG1404	Belongs to the peptidase S8 family
FYK61_RS17585	COG5295	Hep Hag repeat protein
FYK61_RS17590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FYK61_RS17590	COG0047	phosphoribosylformylglycinamidine synthase activity
FYK61_RS17595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FYK61_RS17600	COG4974	Belongs to the 'phage' integrase family
FYK61_RS17615	COG0795	lipopolysaccharide-transporting ATPase activity
FYK61_RS17625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FYK61_RS17640	COG0525	valine-tRNA ligase activity
FYK61_RS17655	COG0741	lytic transglycosylase activity
FYK61_RS17680	COG1183	phosphatidylcholine synthase activity
FYK61_RS17690	COG0442	prolyl-tRNA aminoacylation
FYK61_RS17705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FYK61_RS17710	COG1127	ABC transporter
FYK61_RS17715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FYK61_RS17715	COG3218	ABC-type transport auxiliary lipoprotein component
FYK61_RS17745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FYK61_RS17750	COG0662	Cupin 2, conserved barrel domain protein
FYK61_RS17750	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FYK61_RS17780	COG2086	electron transfer activity
FYK61_RS17795	COG0546	phosphoglycolate phosphatase activity
FYK61_RS17795	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FYK61_RS17800	COG0277	FAD linked oxidase domain protein
FYK61_RS17810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FYK61_RS17840	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FYK61_RS17845	COG0438	transferase activity, transferring glycosyl groups
FYK61_RS17865	COG0438	transferase activity, transferring glycosyl groups
FYK61_RS17870	COG0626	cystathionine gamma-synthase activity
FYK61_RS17900	COG0625	glutathione transferase activity
FYK61_RS17910	COG0513	Belongs to the DEAD box helicase family
FYK61_RS17920	COG4771	TonB-dependent receptor
FYK61_RS17925	COG0720	synthase
FYK61_RS17945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FYK61_RS17950	COG1956	GAF domain-containing protein
FYK61_RS17960	COG2819	hydrolase of the alpha beta superfamily
FYK61_RS17970	COG0546	phosphoglycolate phosphatase activity
FYK61_RS17975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FYK61_RS17980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FYK61_RS17995	COG0339	signal peptide processing
FYK61_RS18045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FYK61_RS18050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FYK61_RS18055	COG1136	(ABC) transporter
FYK61_RS18060	COG0577	efflux transmembrane transporter activity
FYK61_RS18065	COG1136	(ABC) transporter
FYK61_RS18065	COG0577	efflux transmembrane transporter activity
FYK61_RS18080	COG4191	Histidine kinase
FYK61_RS18085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FYK61_RS18100	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FYK61_RS18105	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FYK61_RS18110	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FYK61_RS18115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FYK61_RS18120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FYK61_RS18125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FYK61_RS18135	COG0356	it plays a direct role in the translocation of protons across the membrane
FYK61_RS18155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FYK61_RS18165	COG0508	dehydrogenase complex catalyzes the overall conversion of
FYK61_RS18200	COG2011	ABC-type metal ion transport system permease component
FYK61_RS18205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FYK61_RS18210	COG0697	spore germination
FYK61_RS18215	COG1666	GTP binding
FYK61_RS18225	COG2198	Histidine kinase
FYK61_RS18225	COG0784	Response regulator, receiver
FYK61_RS18225	COG5002	protein histidine kinase activity
FYK61_RS18245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FYK61_RS18250	COG1187	pseudouridine synthase activity
FYK61_RS18275	COG2202	Pas domain
FYK61_RS18275	COG2205	protein histidine kinase activity
FYK61_RS18295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FYK61_RS18300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FYK61_RS18355	COG0842	Transport permease protein
FYK61_RS18360	COG1131	(ABC) transporter
FYK61_RS18365	COG0025	NhaP-type Na H and K H
FYK61_RS18370	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FYK61_RS18375	COG1573	uracil-dna glycosylase
FYK61_RS18385	COG3384	dioxygenase
FYK61_RS18395	COG0583	DNA-binding transcription factor activity
FYK61_RS18405	COG0667	Aldo Keto reductase
FYK61_RS18415	COG3590	peptidase
FYK61_RS18430	COG0531	amino acid
FYK61_RS18445	COG2972	Histidine kinase
FYK61_RS18460	COG3685	Protein conserved in bacteria
FYK61_RS18465	COG3546	catalase activity
FYK61_RS18500	COG2204	response regulator
FYK61_RS18510	COG1271	oxidase subunit
FYK61_RS18515	COG1294	oxidase, subunit
FYK61_RS18530	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS18535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FYK61_RS18555	COG1132	(ABC) transporter
FYK61_RS18570	COG1063	alcohol dehydrogenase
FYK61_RS18645	COG0251	oxidation-reduction process
FYK61_RS18660	COG0840	transmembrane signaling receptor activity
FYK61_RS18675	COG0583	DNA-binding transcription factor activity
FYK61_RS18680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FYK61_RS18710	COG0659	secondary active sulfate transmembrane transporter activity
FYK61_RS18720	COG0024	Methionine aminopeptidase
FYK61_RS18755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FYK61_RS18830	COG3179	chitinase
FYK61_RS19000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FYK61_RS19005	COG1490	D-aminoacyl-tRNA deacylase activity
FYK61_RS19010	COG1560	Kdo2-lipid A biosynthetic process
FYK61_RS19060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FYK61_RS19060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FYK61_RS19065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FYK61_RS19070	COG0242	peptide deformylase activity
FYK61_RS19075	COG1652	LysM domain
FYK61_RS19080	COG0758	DNA mediated transformation
FYK61_RS19100	COG1754	DNA topoisomerase type I activity
FYK61_RS19100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FYK61_RS19105	COG0009	L-threonylcarbamoyladenylate synthase
FYK61_RS19120	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS19130	COG0616	signal peptide processing
FYK61_RS19135	COG0534	Mate efflux family protein
FYK61_RS19155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FYK61_RS19160	COG0625	glutathione transferase activity
FYK61_RS19175	COG1252	NADH dehydrogenase
FYK61_RS19185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FYK61_RS19190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FYK61_RS19195	COG2201	protein-glutamate methylesterase activity
FYK61_RS19200	COG2177	Part of the ABC transporter FtsEX involved in
FYK61_RS19205	COG2884	Cell division ATP-binding protein ftsE
FYK61_RS19210	COG0513	Belongs to the DEAD box helicase family
FYK61_RS19215	COG3118	belongs to the thioredoxin family
FYK61_RS19220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FYK61_RS19225	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FYK61_RS19230	COG0583	DNA-binding transcription factor activity
FYK61_RS19250	COG1652	LysM domain
FYK61_RS19255	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FYK61_RS19255	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FYK61_RS19260	COG1473	amidohydrolase
FYK61_RS19265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FYK61_RS19270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FYK61_RS19290	COG5383	Protein conserved in bacteria
FYK61_RS19340	COG4948	Mandelate Racemase Muconate Lactonizing
FYK61_RS19350	COG0531	amino acid
FYK61_RS19365	COG4682	membrane
FYK61_RS19370	COG2133	pyrroloquinoline quinone binding
FYK61_RS19380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FYK61_RS19385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FYK61_RS19395	COG1610	YqeY-like protein
FYK61_RS19400	COG1295	ribonuclease BN
FYK61_RS19405	COG0358	DNA primase activity
FYK61_RS19420	COG0109	protoheme IX farnesyltransferase activity
FYK61_RS19450	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FYK61_RS19465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FYK61_RS19505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FYK61_RS19510	COG0739	heme binding
FYK61_RS19515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FYK61_RS19525	COG2223	nitrite transmembrane transporter activity
FYK61_RS19535	COG0708	Exodeoxyribonuclease III
FYK61_RS19540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FYK61_RS19550	COG1192	Involved in chromosome partitioning
FYK61_RS19555	COG1475	DNA binding
FYK61_RS19570	COG0463	Glycosyl transferase, family 2
FYK61_RS19585	COG0756	dUTP diphosphatase activity
FYK61_RS19590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FYK61_RS19595	COG2003	Belongs to the UPF0758 family
FYK61_RS19600	COG0018	arginyl-trna synthetase
FYK61_RS19615	COG4221	oxidoreductase activity
FYK61_RS19620	COG2755	lipolytic protein G-D-S-L family
FYK61_RS19620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FYK61_RS19630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FYK61_RS19635	COG1166	arginine decarboxylase activity
FYK61_RS19640	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FYK61_RS19660	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FYK61_RS19660	COG3291	Pkd domain containing protein
FYK61_RS19675	COG0606	chelatase, subunit chli
FYK61_RS19690	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FYK61_RS19715	COG1690	Belongs to the RtcB family
FYK61_RS19750	COG1090	epimerase
FYK61_RS19760	COG0642	Histidine kinase
FYK61_RS19780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FYK61_RS19805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FYK61_RS19810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FYK61_RS19825	COG0753	catalase activity
FYK61_RS19840	COG2197	response regulator
FYK61_RS19850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FYK61_RS19855	COG1136	(ABC) transporter
FYK61_RS19880	COG0697	spore germination
FYK61_RS19900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FYK61_RS19905	COG0180	Tryptophanyl-tRNA synthetase
FYK61_RS19910	COG3237	CsbD-like
FYK61_RS19950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FYK61_RS19970	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FYK61_RS20015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FYK61_RS20035	COG1199	ATP-dependent helicase activity
FYK61_RS20050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FYK61_RS20120	COG0625	glutathione transferase activity
FYK61_RS20155	COG4555	ABC transporter
FYK61_RS20165	COG1476	TRANSCRIPTIONal
FYK61_RS20185	COG1230	cation diffusion facilitator family transporter
FYK61_RS20210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FYK61_RS20215	COG1131	(ABC) transporter
FYK61_RS20220	COG0842	Transport permease protein
FYK61_RS20225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FYK61_RS20255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FYK61_RS20260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FYK61_RS20270	COG0045	succinate-CoA ligase (ADP-forming) activity
FYK61_RS20270	COG1042	CoA-binding domain protein
FYK61_RS20270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FYK61_RS20275	COG2239	Acts as a magnesium transporter
FYK61_RS20290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FYK61_RS20295	COG3387	PFAM Glycoside hydrolase 15-related
FYK61_RS20310	COG3100	YcgL domain-containing protein
FYK61_RS20315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FYK61_RS20325	COG0463	Glycosyl transferase, family 2
FYK61_RS20340	COG3039	Transposase
FYK61_RS20345	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS20385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FYK61_RS20400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FYK61_RS20425	COG0823	Involved in the tonB-independent uptake of proteins
FYK61_RS20425	COG1506	peptidase
FYK61_RS20425	COG4946	Tricorn protease homolog
FYK61_RS20440	COG0408	coproporphyrinogen oxidase activity
FYK61_RS20475	COG0515	serine threonine protein kinase
FYK61_RS20480	COG0631	protein serine/threonine phosphatase activity
FYK61_RS20540	COG1595	DNA-templated transcription, initiation
FYK61_RS20650	COG0210	DNA helicase
FYK61_RS20660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FYK61_RS20665	COG0583	DNA-binding transcription factor activity
FYK61_RS20670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FYK61_RS20680	COG2159	amidohydrolase
FYK61_RS20700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FYK61_RS20720	COG0357	Ribosomal RNA small subunit methyltransferase G
FYK61_RS20725	COG3540	Alkaline phosphatase
FYK61_RS20735	COG2091	lysine biosynthetic process via aminoadipic acid
FYK61_RS20750	COG0708	Exodeoxyribonuclease III
FYK61_RS20755	COG1940	carbohydrate kinase activity
FYK61_RS20755	COG1846	Transcriptional regulator
FYK61_RS20765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FYK61_RS20775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FYK61_RS20780	COG3162	membrane
FYK61_RS20790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FYK61_RS20815	COG3507	Belongs to the glycosyl hydrolase 43 family
FYK61_RS20835	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS20840	COG0179	Fumarylacetoacetate (FAA) hydrolase
FYK61_RS20845	COG4948	Mandelate Racemase Muconate Lactonizing
FYK61_RS20850	COG3254	rhamnose metabolic process
FYK61_RS20855	COG0738	Major facilitator superfamily
FYK61_RS20860	COG1414	Transcriptional regulator
FYK61_RS20865	COG1971	Probably functions as a manganese efflux pump
FYK61_RS20870	COG2205	protein histidine kinase activity
FYK61_RS20880	COG3459	Glycosyltransferase 36 associated
FYK61_RS20885	COG2211	Major facilitator Superfamily
FYK61_RS20890	COG3265	gluconokinase activity
FYK61_RS20895	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FYK61_RS20920	COG2911	Protein conserved in bacteria
FYK61_RS20925	COG0729	surface antigen
FYK61_RS20960	COG0752	glycyl-tRNA synthetase alpha subunit
FYK61_RS20965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FYK61_RS20970	COG0519	Catalyzes the synthesis of GMP from XMP
FYK61_RS20970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FYK61_RS20980	COG0805	protein transport
FYK61_RS20985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FYK61_RS20990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FYK61_RS21000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FYK61_RS21015	COG2974	May be involved in recombination
FYK61_RS21020	COG0037	tRNA processing
FYK61_RS21025	COG2115	Belongs to the xylose isomerase family
FYK61_RS21035	COG3661	Belongs to the glycosyl hydrolase 67 family
FYK61_RS21045	COG4948	Mandelate Racemase Muconate Lactonizing
FYK61_RS21055	COG1472	Belongs to the glycosyl hydrolase 3 family
FYK61_RS21060	COG0246	Mannitol dehydrogenase
FYK61_RS21110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FYK61_RS21135	COG3386	PFAM SMP-30 Gluconolaconase
FYK61_RS21145	COG3250	beta-galactosidase activity
FYK61_RS21150	COG1904	glucuronate isomerase
FYK61_RS21155	COG3693	PFAM glycoside hydrolase, family 10
FYK61_RS21165	COG3693	PFAM glycoside hydrolase, family 10
FYK61_RS21180	COG2211	Major facilitator Superfamily
FYK61_RS21245	COG3321	synthase
FYK61_RS21245	COG0604	alcohol dehydrogenase
FYK61_RS21245	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS21250	COG2937	Belongs to the GPAT DAPAT family
FYK61_RS21280	COG0284	orotidine-5'-phosphate decarboxylase activity
FYK61_RS21285	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FYK61_RS21290	COG3132	Protein of unknown function, DUF480
FYK61_RS21305	COG0210	DNA helicase
FYK61_RS21310	COG1435	thymidine kinase activity
FYK61_RS21320	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FYK61_RS21330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FYK61_RS21360	COG3135	benzoate transporter
FYK61_RS21380	COG0676	glucose-6-phosphate 1-epimerase activity
FYK61_RS21390	COG3012	SEC-C Motif Domain Protein
FYK61_RS21395	COG0730	response to heat
FYK61_RS21415	COG0302	gtp cyclohydrolase
FYK61_RS21430	COG1566	PFAM secretion protein HlyD family protein
FYK61_RS21440	COG1289	transmembrane transporter activity
FYK61_RS21445	COG0477	Major facilitator Superfamily
FYK61_RS21455	COG0583	DNA-binding transcription factor activity
FYK61_RS21460	COG4221	oxidoreductase activity
FYK61_RS21525	COG0564	pseudouridine synthase activity
FYK61_RS21555	COG1309	transcriptional regulator
FYK61_RS21565	COG1028	Short-chain dehydrogenase reductase Sdr
FYK61_RS21600	COG1074	ATP-dependent DNA helicase activity
FYK61_RS21605	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FYK61_RS21640	COG1127	ABC transporter
FYK61_RS21645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FYK61_RS21650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FYK61_RS21665	COG2853	Lipoprotein
FYK61_RS21675	COG0386	Belongs to the glutathione peroxidase family
FYK61_RS21700	COG0625	glutathione transferase activity
FYK61_RS21710	COG0531	amino acid
FYK61_RS21715	COG3537	Alpha-1,2-mannosidase
FYK61_RS21725	COG3706	GGDEF domain
FYK61_RS21730	COG3835	regulator
FYK61_RS21735	COG1929	Belongs to the glycerate kinase type-1 family
FYK61_RS21740	COG2271	Major facilitator Superfamily
FYK61_RS21755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FYK61_RS21760	COG0861	Integral membrane protein TerC family
FYK61_RS21770	COG0584	glycerophosphoryl diester phosphodiesterase
FYK61_RS21785	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FYK61_RS21795	COG0706	membrane insertase activity
FYK61_RS21800	COG0594	ribonuclease P activity