locus-tag	class	description
G3566_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G3566_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G3566_RS00020	COG0187	DNA topoisomerase II activity
G3566_RS00030	COG0501	Belongs to the peptidase M48B family
G3566_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G3566_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3566_RS00120	COG0793	Belongs to the peptidase S41A family
G3566_RS00125	COG4942	peptidase
G3566_RS00135	COG2234	aminopeptidase activity
G3566_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
G3566_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
G3566_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
G3566_RS00165	COG1064	alcohol dehydrogenase
G3566_RS00175	COG0493	'glutamate synthase
G3566_RS00180	COG0070	glutamate synthase
G3566_RS00180	COG0069	glutamate synthase activity
G3566_RS00180	COG0067	glutamate synthase
G3566_RS00265	COG1111	helicase
G3566_RS00265	COG1205	dead DEAH box helicase
G3566_RS00270	COG1272	protein, Hemolysin III
G3566_RS00290	COG0300	oxidoreductase activity
G3566_RS00295	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS00315	COG2249	NAD(P)H dehydrogenase (quinone) activity
G3566_RS00340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G3566_RS00365	COG3237	CsbD-like
G3566_RS00415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3566_RS00420	COG0477	Major facilitator Superfamily
G3566_RS00460	COG0714	Associated with various cellular activities
G3566_RS00490	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G3566_RS00500	COG4772	TonB-dependent receptor
G3566_RS00515	COG1012	belongs to the aldehyde dehydrogenase family
G3566_RS00540	COG1304	FMN binding
G3566_RS00550	COG4585	Histidine kinase
G3566_RS00555	COG2197	response regulator
G3566_RS00575	COG3710	Transcriptional regulator
G3566_RS00580	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G3566_RS00685	COG0366	Alpha amylase catalytic
G3566_RS00690	COG0366	Alpha amylase catalytic
G3566_RS00695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G3566_RS00715	COG2755	lipolytic protein G-D-S-L family
G3566_RS00715	COG0657	acetylesterase activity
G3566_RS00725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3566_RS00740	COG3507	Belongs to the glycosyl hydrolase 43 family
G3566_RS00745	COG1609	Transcriptional regulator
G3566_RS00750	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
G3566_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS00765	COG2755	lipolytic protein G-D-S-L family
G3566_RS00775	COG3186	Phenylalanine-4-hydroxylase
G3566_RS00780	COG1522	sequence-specific DNA binding
G3566_RS00790	COG1752	Esterase of the alpha-beta hydrolase superfamily
G3566_RS00800	COG1119	ATPase activity
G3566_RS00815	COG1125	glycine betaine transport
G3566_RS00830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G3566_RS00860	COG0489	protein tyrosine kinase activity
G3566_RS00865	COG2062	phosphohistidine phosphatase, SixA
G3566_RS00875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3566_RS00920	COG1968	undecaprenyl-diphosphatase activity
G3566_RS00925	COG0174	glutamine synthetase
G3566_RS00930	COG0347	Belongs to the P(II) protein family
G3566_RS00935	COG0004	ammonium transporteR
G3566_RS00945	COG3852	Histidine kinase
G3566_RS00950	COG2204	response regulator
G3566_RS00955	COG2032	superoxide dismutase activity
G3566_RS00960	COG2032	superoxide dismutase activity
G3566_RS00980	COG0183	Belongs to the thiolase family
G3566_RS01015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G3566_RS01020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G3566_RS01025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G3566_RS01040	COG0028	Belongs to the TPP enzyme family
G3566_RS01045	COG2205	protein histidine kinase activity
G3566_RS01070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G3566_RS01085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G3566_RS01095	COG0596	Alpha beta hydrolase
G3566_RS01100	COG0727	PFAM Uncharacterised protein family (UPF0153)
G3566_RS01105	COG0318	PFAM AMP-dependent synthetase and ligase
G3566_RS01110	COG0745	RESPONSE REGULATOR receiver
G3566_RS01120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3566_RS01140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G3566_RS01150	COG0564	pseudouridine synthase activity
G3566_RS01170	COG1446	asparaginase
G3566_RS01175	COG0339	signal peptide processing
G3566_RS01210	COG0475	glutathione-regulated potassium exporter activity
G3566_RS01215	COG0583	DNA-binding transcription factor activity
G3566_RS01220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G3566_RS01225	COG2224	Isocitrate lyase
G3566_RS01255	COG4770	biotin carboxylase activity
G3566_RS01260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G3566_RS01265	COG1960	acyl-CoA dehydrogenase activity
G3566_RS01330	COG0697	spore germination
G3566_RS01340	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G3566_RS01345	COG1846	Transcriptional regulator
G3566_RS01350	COG1764	response to oxidative stress
G3566_RS01375	COG2130	NADP-dependent
G3566_RS01390	COG1187	pseudouridine synthase activity
G3566_RS01405	COG1643	Atp-dependent helicase
G3566_RS01410	COG4807	Protein conserved in bacteria
G3566_RS01415	COG2351	hydroxyisourate hydrolase activity
G3566_RS01420	COG2072	flavoprotein involved in K transport
G3566_RS01440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G3566_RS01485	COG2252	PERMEase
G3566_RS01505	COG0084	hydrolase, TatD family'
G3566_RS01515	COG0583	DNA-binding transcription factor activity
G3566_RS01520	COG2814	Major facilitator Superfamily
G3566_RS01530	COG2267	carboxylic ester hydrolase activity
G3566_RS01535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G3566_RS01540	COG1902	pentaerythritol trinitrate reductase activity
G3566_RS01560	COG0745	RESPONSE REGULATOR receiver
G3566_RS01565	COG2205	protein histidine kinase activity
G3566_RS01570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3566_RS01590	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G3566_RS01595	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G3566_RS01600	COG0583	DNA-binding transcription factor activity
G3566_RS01630	COG0702	epimerase
G3566_RS01635	COG1733	regulation of RNA biosynthetic process
G3566_RS01660	COG0129	dihydroxy-acid dehydratase activity
G3566_RS01675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G3566_RS01730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G3566_RS01735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G3566_RS01760	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G3566_RS01765	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G3566_RS01775	COG3485	protocatechuate 3,4-dioxygenase
G3566_RS01780	COG3485	protocatechuate 3,4-dioxygenase
G3566_RS01790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3566_RS01795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G3566_RS01805	COG1414	Transcriptional regulator
G3566_RS01815	COG0657	acetylesterase activity
G3566_RS01825	COG0445	tRNA wobble uridine modification
G3566_RS01835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G3566_RS01860	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS01865	COG2267	carboxylic ester hydrolase activity
G3566_RS01875	COG0156	8-amino-7-oxononanoate synthase activity
G3566_RS01880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G3566_RS01885	COG1040	competence protein
G3566_RS01890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G3566_RS01960	COG1196	nuclear chromosome segregation
G3566_RS02010	COG5297	Belongs to the glycosyl hydrolase family 6
G3566_RS02065	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G3566_RS02135	COG3264	Mechanosensitive ion channel
G3566_RS02135	COG1511	domain protein
G3566_RS02140	COG1368	sulfuric ester hydrolase activity
G3566_RS02145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G3566_RS02150	COG2354	Protein conserved in bacteria
G3566_RS02160	COG0297	glycogen (starch) synthase activity
G3566_RS02165	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G3566_RS02170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G3566_RS02195	COG0702	epimerase
G3566_RS02200	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS02230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3566_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS02245	COG0513	Belongs to the DEAD box helicase family
G3566_RS02255	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3566_RS02270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G3566_RS02280	COG3483	tryptophan 2,3-dioxygenase activity
G3566_RS02285	COG3104	oligopeptide transport
G3566_RS02305	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
G3566_RS02320	COG1320	monovalent cation:proton antiporter activity
G3566_RS02325	COG2212	antiporter activity
G3566_RS02335	COG0651	ATP synthesis coupled electron transport
G3566_RS02340	COG1006	Multisubunit Na H antiporter MnhC subunit
G3566_RS02345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G3566_RS02345	COG2111	Na H antiporter
G3566_RS02370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G3566_RS02375	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G3566_RS02390	COG0456	acetyltransferase
G3566_RS02395	COG1597	lipid kinase activity
G3566_RS02425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G3566_RS02430	COG0134	indole-3-glycerol-phosphate synthase activity
G3566_RS02440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3566_RS02445	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G3566_RS02455	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
G3566_RS02465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G3566_RS02480	COG1051	belongs to the nudix hydrolase family
G3566_RS02520	COG0316	Belongs to the HesB IscA family
G3566_RS02535	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G3566_RS02550	COG2814	Major facilitator Superfamily
G3566_RS02560	COG2814	Major facilitator Superfamily
G3566_RS02565	COG1289	transmembrane transporter activity
G3566_RS02570	COG0151	Belongs to the GarS family
G3566_RS02580	COG0138	bifunctional purine biosynthesis protein purh
G3566_RS02585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G3566_RS02590	COG2267	carboxylic ester hydrolase activity
G3566_RS02595	COG2453	phosphatase
G3566_RS02595	COG0671	phosphoesterase, PA-phosphatase related
G3566_RS02620	COG4589	Belongs to the CDS family
G3566_RS02625	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G3566_RS02650	COG2264	protein methyltransferase activity
G3566_RS02665	COG0439	Biotin carboxylase
G3566_RS02675	COG0511	ligase activity, forming carbon-carbon bonds
G3566_RS02680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G3566_RS02690	COG1324	tolerance protein
G3566_RS02700	COG2356	endonuclease I
G3566_RS02710	COG0459	protein refolding
G3566_RS02730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G3566_RS02745	COG3386	PFAM SMP-30 Gluconolaconase
G3566_RS02755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G3566_RS02760	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G3566_RS02785	COG0778	Nitroreductase
G3566_RS02790	COG2353	YceI-like domain
G3566_RS02815	COG3052	prosthetic group binding
G3566_RS02845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G3566_RS02855	COG1802	Transcriptional regulator
G3566_RS02975	COG1082	Xylose isomerase domain protein TIM barrel
G3566_RS02990	COG4221	oxidoreductase activity
G3566_RS03005	COG4221	oxidoreductase activity
G3566_RS03015	COG0435	Glutathione S-transferase
G3566_RS03050	COG1506	peptidase
G3566_RS03050	COG0823	Involved in the tonB-independent uptake of proteins
G3566_RS03085	COG0697	spore germination
G3566_RS03100	COG1113	amino acid transport
G3566_RS03120	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
G3566_RS03165	COG0840	transmembrane signaling receptor activity
G3566_RS03170	COG5297	Belongs to the glycosyl hydrolase family 6
G3566_RS03170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
G3566_RS03175	COG0659	secondary active sulfate transmembrane transporter activity
G3566_RS03190	COG2943	transferase activity, transferring hexosyl groups
G3566_RS03200	COG3275	phosphorelay sensor kinase activity
G3566_RS03210	COG0181	hydroxymethylbilane synthase activity
G3566_RS03235	COG1505	serine-type exopeptidase activity
G3566_RS03240	COG0436	Aminotransferase
G3566_RS03250	COG2832	Protein of unknown function (DUF454)
G3566_RS03260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G3566_RS03270	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G3566_RS03275	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G3566_RS03280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G3566_RS03305	COG2226	methyltransferase
G3566_RS03310	COG5001	Diguanylate cyclase
G3566_RS03310	COG3300	MHYT domain
G3566_RS03315	COG0308	aminopeptidase N
G3566_RS03360	COG3284	Transcriptional regulator
G3566_RS03365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G3566_RS03370	COG1077	Cell shape determining protein MreB Mrl
G3566_RS03375	COG1792	Involved in formation and maintenance of cell shape
G3566_RS03390	COG0772	Belongs to the SEDS family
G3566_RS03400	COG2951	lytic endotransglycosylase activity
G3566_RS03405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G3566_RS03410	COG1686	Belongs to the peptidase S11 family
G3566_RS03420	COG2921	Belongs to the UPF0250 family
G3566_RS03425	COG0321	lipoyl(octanoyl) transferase activity
G3566_RS03430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G3566_RS03445	COG0583	DNA-binding transcription factor activity
G3566_RS03455	COG1051	belongs to the nudix hydrolase family
G3566_RS03455	COG1056	cytidyltransferase-related domain
G3566_RS03490	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G3566_RS03495	COG0673	inositol 2-dehydrogenase activity
G3566_RS03500	COG2823	Periplasmic or secreted lipoprotein
G3566_RS03505	COG4251	negative regulation of phosphorylation
G3566_RS03510	COG0784	Response regulator, receiver
G3566_RS03515	COG4191	Histidine kinase
G3566_RS03520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G3566_RS03575	COG1459	type II secretion system
G3566_RS03580	COG2165	general secretion pathway protein
G3566_RS03595	COG4795	General secretion pathway protein
G3566_RS03625	COG3250	beta-galactosidase activity
G3566_RS03640	COG2188	Transcriptional regulator
G3566_RS03650	COG1609	Transcriptional regulator
G3566_RS03655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G3566_RS03660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G3566_RS03675	COG0617	tRNA 3'-terminal CCA addition
G3566_RS03680	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G3566_RS03685	COG1012	belongs to the aldehyde dehydrogenase family
G3566_RS03690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G3566_RS03705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G3566_RS03720	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G3566_RS03725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G3566_RS03740	COG2205	protein histidine kinase activity
G3566_RS03770	COG3791	Glutathione-dependent formaldehyde-activating
G3566_RS03785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3566_RS03795	COG0697	spore germination
G3566_RS03805	COG0488	(ABC) transporter
G3566_RS03815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G3566_RS03820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G3566_RS03830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G3566_RS03830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G3566_RS03850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G3566_RS03855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G3566_RS03860	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G3566_RS03880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G3566_RS03885	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G3566_RS03890	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
G3566_RS03895	COG2205	protein histidine kinase activity
G3566_RS03900	COG0745	RESPONSE REGULATOR receiver
G3566_RS03920	COG0277	FAD linked oxidase domain protein
G3566_RS03925	COG1988	membrane-bound metal-dependent
G3566_RS03930	COG0792	nuclease activity
G3566_RS03960	COG0275	rRNA processing
G3566_RS03965	COG3116	cell division
G3566_RS03975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G3566_RS03980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G3566_RS03985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G3566_RS03995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G3566_RS04000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G3566_RS04005	COG1181	Belongs to the D-alanine--D-alanine ligase family
G3566_RS04010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G3566_RS04025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G3566_RS04035	COG0739	heme binding
G3566_RS04040	COG0653	protein targeting
G3566_RS04045	COG0494	nUDIX hydrolase
G3566_RS04055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G3566_RS04065	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS04065	COG3321	synthase
G3566_RS04065	COG0604	alcohol dehydrogenase
G3566_RS04085	COG0366	Alpha amylase catalytic
G3566_RS04120	COG2226	methyltransferase
G3566_RS04125	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G3566_RS04135	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G3566_RS04175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G3566_RS04185	COG4106	trans-aconitate 2-methyltransferase activity
G3566_RS04190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G3566_RS04200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G3566_RS04205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G3566_RS04210	COG0667	Aldo Keto reductase
G3566_RS04220	COG4771	TonB-dependent receptor
G3566_RS04240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3566_RS04245	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G3566_RS04255	COG2175	clavaminate synthase activity
G3566_RS04265	COG4181	ATPase activity
G3566_RS04280	COG0642	Histidine kinase
G3566_RS04290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G3566_RS04310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G3566_RS04315	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G3566_RS04330	COG3829	transcription factor binding
G3566_RS04340	COG1116	anion transmembrane transporter activity
G3566_RS04345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3566_RS04355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3566_RS04360	COG0431	NADPH-dependent FMN reductase
G3566_RS04385	COG0747	negative chemotaxis
G3566_RS04395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G3566_RS04405	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G3566_RS04410	COG2967	ApaG domain
G3566_RS04415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G3566_RS04420	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G3566_RS04425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3566_RS04430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G3566_RS04435	COG0123	including yeast histone deacetylase and acetoin utilization protein
G3566_RS04440	COG2096	Adenosyltransferase
G3566_RS04455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3566_RS04460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3566_RS04490	COG3384	dioxygenase
G3566_RS04495	COG0583	DNA-binding transcription factor activity
G3566_RS04510	COG1024	Enoyl-CoA hydratase
G3566_RS04540	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
G3566_RS04565	COG0697	spore germination
G3566_RS04575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3566_RS04600	COG2197	response regulator
G3566_RS04610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3566_RS04620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G3566_RS04625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G3566_RS04630	COG0583	DNA-binding transcription factor activity
G3566_RS04635	COG3634	alkyl hydroperoxide reductase activity
G3566_RS04645	COG2890	protein-(glutamine-N5) methyltransferase activity
G3566_RS04665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G3566_RS04665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G3566_RS04735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3566_RS04740	COG1404	Belongs to the peptidase S8 family
G3566_RS04745	COG1404	Belongs to the peptidase S8 family
G3566_RS04750	COG1404	Belongs to the peptidase S8 family
G3566_RS04755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G3566_RS04780	COG1295	ribonuclease BN
G3566_RS04785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3566_RS04790	COG1254	Belongs to the acylphosphatase family
G3566_RS04805	COG0521	Mo-molybdopterin cofactor biosynthetic process
G3566_RS04815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G3566_RS04820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G3566_RS04830	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G3566_RS04835	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G3566_RS04845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G3566_RS04850	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G3566_RS04855	COG0193	aminoacyl-tRNA hydrolase activity
G3566_RS04860	COG0012	GTP binding
G3566_RS04880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G3566_RS04895	COG0250	Participates in transcription elongation, termination and antitermination
G3566_RS04900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G3566_RS04905	COG0081	regulation of translation
G3566_RS04910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G3566_RS04915	COG0222	ribosome binding
G3566_RS04920	COG0085	RNA polymerase activity
G3566_RS04925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G3566_RS04930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G3566_RS04935	COG0049	tRNA binding
G3566_RS04940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G3566_RS04945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G3566_RS04950	COG0051	transcription antitermination factor activity, RNA binding
G3566_RS04955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G3566_RS04960	COG0088	Forms part of the polypeptide exit tunnel
G3566_RS04970	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G3566_RS04975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G3566_RS04985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G3566_RS04990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G3566_RS04995	COG0255	Belongs to the universal ribosomal protein uL29 family
G3566_RS05000	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G3566_RS05010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G3566_RS05015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G3566_RS05025	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G3566_RS05030	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G3566_RS05035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G3566_RS05045	COG1841	ribosomal large subunit assembly
G3566_RS05050	COG0200	Binds to the 23S rRNA
G3566_RS05055	COG0201	protein transport
G3566_RS05080	COG0203	ribosomal protein L17
G3566_RS05085	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G3566_RS05100	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G3566_RS05115	COG0154	amidase activity
G3566_RS05125	COG1217	gtp-binding protein TYPA
G3566_RS05130	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G3566_RS05135	COG0039	L-malate dehydrogenase activity
G3566_RS05140	COG0625	glutathione transferase activity
G3566_RS05150	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3566_RS05150	COG1902	pentaerythritol trinitrate reductase activity
G3566_RS05155	COG0604	alcohol dehydrogenase
G3566_RS05180	COG0156	8-amino-7-oxononanoate synthase activity
G3566_RS05185	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G3566_RS05190	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G3566_RS05195	COG4208	sulfate ABC transporter
G3566_RS05200	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G3566_RS05230	COG0406	alpha-ribazole phosphatase activity
G3566_RS05235	COG0285	dihydrofolate synthase activity
G3566_RS05255	COG2833	Protein of unknown function (DUF455)
G3566_RS05260	COG3291	Pkd domain containing protein
G3566_RS05270	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3566_RS05275	COG0671	phosphoesterase, PA-phosphatase related
G3566_RS05280	COG0438	transferase activity, transferring glycosyl groups
G3566_RS05290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G3566_RS05305	COG4783	chaperone-mediated protein folding
G3566_RS05320	COG0473	3-isopropylmalate dehydrogenase activity
G3566_RS05350	COG3852	Histidine kinase
G3566_RS05360	COG0544	peptidyl-prolyl cis-trans isomerase activity
G3566_RS05370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G3566_RS05400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3566_RS05410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3566_RS05420	COG0328	RNA-DNA hybrid ribonuclease activity
G3566_RS05425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G3566_RS05430	COG0631	protein serine/threonine phosphatase activity
G3566_RS05445	COG0859	PFAM glycosyl transferase family 9
G3566_RS05450	COG3642	lipopolysaccharide core region biosynthetic process
G3566_RS05455	COG1234	tRNA 3'-trailer cleavage
G3566_RS05460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G3566_RS05470	COG0315	cyclic pyranopterin monophosphate synthase activity
G3566_RS05475	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G3566_RS05480	COG0314	molybdopterin synthase activity
G3566_RS05530	COG1074	ATP-dependent DNA helicase activity
G3566_RS05550	COG2003	Belongs to the UPF0758 family
G3566_RS05610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G3566_RS05615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G3566_RS05620	COG0537	adenosine 5'-monophosphoramidase activity
G3566_RS05640	COG0714	Associated with various cellular activities
G3566_RS05665	COG0424	maF-like protein
G3566_RS05670	COG1399	metal-binding, possibly nucleic acid-binding protein
G3566_RS05680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G3566_RS05690	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G3566_RS05695	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS05710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G3566_RS05715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G3566_RS05740	COG3829	transcription factor binding
G3566_RS05780	COG2373	Large extracellular alpha-helical protein
G3566_RS05795	COG4953	penicillin-binding protein 1C
G3566_RS05805	COG0678	peroxiredoxin activity
G3566_RS05825	COG0330	HflC and HflK could
G3566_RS05830	COG0330	HflC and HflK could
G3566_RS05840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G3566_RS05845	COG0308	aminopeptidase N
G3566_RS05855	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS05860	COG1309	transcriptional regulator
G3566_RS05915	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G3566_RS05950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G3566_RS05960	COG3387	PFAM Glycoside hydrolase 15-related
G3566_RS05965	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS05970	COG3537	Alpha-1,2-mannosidase
G3566_RS05975	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS05990	COG0492	ferredoxin-NADP+ reductase activity
G3566_RS06020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3566_RS06025	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G3566_RS06030	COG2080	2 iron, 2 sulfur cluster binding
G3566_RS06065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G3566_RS06080	COG0587	DNA-directed DNA polymerase activity
G3566_RS06100	COG1297	OPT oligopeptide transporter protein
G3566_RS06115	COG0823	Involved in the tonB-independent uptake of proteins
G3566_RS06115	COG1506	peptidase
G3566_RS06130	COG1917	Cupin 2, conserved barrel domain protein
G3566_RS06130	COG2207	Transcriptional regulator
G3566_RS06150	COG0753	catalase activity
G3566_RS06155	COG0656	L-ascorbic acid biosynthetic process
G3566_RS06165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G3566_RS06165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G3566_RS06170	COG2814	Major facilitator Superfamily
G3566_RS06185	COG2194	sulfuric ester hydrolase activity
G3566_RS06200	COG0745	RESPONSE REGULATOR receiver
G3566_RS06205	COG0642	Histidine kinase
G3566_RS06215	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G3566_RS06220	COG2894	cell division
G3566_RS06225	COG0850	regulation of cytokinetic process
G3566_RS06235	COG4585	Histidine kinase
G3566_RS06240	COG2197	response regulator
G3566_RS06255	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G3566_RS06280	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
G3566_RS06290	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G3566_RS06310	COG1946	Acyl-CoA thioesterase
G3566_RS06325	COG0824	Thioesterase
G3566_RS06330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G3566_RS06335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G3566_RS06340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G3566_RS06345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G3566_RS06350	COG0268	Binds directly to 16S ribosomal RNA
G3566_RS06360	COG0196	riboflavin kinase activity
G3566_RS06365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G3566_RS06370	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G3566_RS06375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G3566_RS06410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3566_RS06415	COG1845	cytochrome c oxidase, subunit III
G3566_RS06420	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G3566_RS06435	COG3152	Membrane
G3566_RS06445	COG2207	Transcriptional regulator
G3566_RS06460	COG1366	Belongs to the anti-sigma-factor antagonist family
G3566_RS06465	COG1366	Belongs to the anti-sigma-factor antagonist family
G3566_RS06470	COG2172	sigma factor antagonist activity
G3566_RS06495	COG4771	TonB-dependent receptor
G3566_RS06505	COG5507	3-demethylubiquinone-9 3-methyltransferase
G3566_RS06510	COG2205	protein histidine kinase activity
G3566_RS06520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G3566_RS06525	COG2205	protein histidine kinase activity
G3566_RS06525	COG3437	response regulator, receiver
G3566_RS06525	COG4999	Histidine kinase
G3566_RS06525	COG3850	Histidine kinase
G3566_RS06530	COG4191	Histidine kinase
G3566_RS06530	COG0784	Response regulator, receiver
G3566_RS06560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G3566_RS06565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G3566_RS06575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3566_RS06580	COG0228	four-way junction DNA binding
G3566_RS06585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G3566_RS06590	COG0336	Belongs to the RNA methyltransferase TrmD family
G3566_RS06595	COG0335	large ribosomal subunit rRNA binding
G3566_RS06600	COG0534	Mate efflux family protein
G3566_RS06620	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G3566_RS06630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G3566_RS06640	COG3209	COG3209 Rhs family protein
G3566_RS06655	COG4245	von Willebrand factor, type A
G3566_RS06660	COG0631	protein serine/threonine phosphatase activity
G3566_RS06665	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
G3566_RS06710	COG2963	transposase activity
G3566_RS06730	COG3250	beta-galactosidase activity
G3566_RS06735	COG3867	Arabinogalactan endo-beta-1,4-galactanase
G3566_RS06755	COG1960	acyl-CoA dehydrogenase activity
G3566_RS06760	COG1024	Enoyl-CoA hydratase
G3566_RS06800	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3566_RS06800	COG1024	Enoyl-CoA hydratase
G3566_RS06815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3566_RS06820	COG0481	GTPase activity
G3566_RS06835	COG0571	ribonuclease III activity
G3566_RS06840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G3566_RS06845	COG1381	Involved in DNA repair and RecF pathway recombination
G3566_RS06855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G3566_RS06860	COG2954	triphosphatase activity
G3566_RS06865	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G3566_RS06870	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
G3566_RS06875	COG3046	protein related to deoxyribodipyrimidine photolyase
G3566_RS06880	COG1472	Belongs to the glycosyl hydrolase 3 family
G3566_RS06885	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
G3566_RS06890	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G3566_RS06895	COG1278	Cold shock
G3566_RS06900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3566_RS06910	COG1201	RNA secondary structure unwinding
G3566_RS06915	COG1793	dna ligase
G3566_RS06925	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G3566_RS06925	COG1793	dna ligase
G3566_RS06955	COG0183	Belongs to the thiolase family
G3566_RS06975	COG1451	nucleotide metabolic process
G3566_RS06980	COG5487	UPF0391 membrane protein
G3566_RS06990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G3566_RS07010	COG1077	Cell shape determining protein MreB Mrl
G3566_RS07015	COG1047	Peptidyl-prolyl cis-trans
G3566_RS07025	COG2824	Alkylphosphonate utilization operon protein PhnA
G3566_RS07030	COG1902	pentaerythritol trinitrate reductase activity
G3566_RS07070	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G3566_RS07070	COG0392	lysyltransferase activity
G3566_RS07080	COG0251	oxidation-reduction process
G3566_RS07085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G3566_RS07100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G3566_RS07125	COG1595	DNA-templated transcription, initiation
G3566_RS07140	COG2878	Part of a membrane complex involved in electron transport
G3566_RS07150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3566_RS07150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3566_RS07165	COG1131	(ABC) transporter
G3566_RS07170	COG0346	lactoylglutathione lyase activity
G3566_RS07175	COG0833	amino acid
G3566_RS07180	COG2040	homocysteine
G3566_RS07190	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G3566_RS07210	COG1695	Transcriptional regulator
G3566_RS07230	COG1981	membrane
G3566_RS07245	COG0825	malonyl-CoA metabolic process
G3566_RS07260	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3566_RS07265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3566_RS07270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3566_RS07275	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3566_RS07290	COG0750	zinc metalloprotease
G3566_RS07295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G3566_RS07300	COG0575	Belongs to the CDS family
G3566_RS07305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G3566_RS07310	COG0233	cytoplasmic translational termination
G3566_RS07315	COG0528	UMP kinase activity
G3566_RS07325	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G3566_RS07330	COG0052	Belongs to the universal ribosomal protein uS2 family
G3566_RS07370	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G3566_RS07380	COG1393	Belongs to the ArsC family
G3566_RS07385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3566_RS07390	COG0367	asparagine synthase
G3566_RS07400	COG4774	siderophore transport
G3566_RS07415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G3566_RS07440	COG1566	PFAM secretion protein HlyD family protein
G3566_RS07445	COG2814	Major facilitator Superfamily
G3566_RS07495	COG0339	signal peptide processing
G3566_RS07500	COG0386	Belongs to the glutathione peroxidase family
G3566_RS07555	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G3566_RS07560	COG0084	hydrolase, TatD family'
G3566_RS07575	COG1960	acyl-CoA dehydrogenase activity
G3566_RS07590	COG0367	asparagine synthase
G3566_RS07600	COG0305	Participates in initiation and elongation during chromosome replication
G3566_RS07605	COG0415	Belongs to the DNA photolyase family
G3566_RS07615	COG0583	DNA-binding transcription factor activity
G3566_RS07660	COG3706	GGDEF domain
G3566_RS07680	COG0546	phosphoglycolate phosphatase activity
G3566_RS07685	COG0758	DNA mediated transformation
G3566_RS07795	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G3566_RS07810	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G3566_RS07820	COG0497	DNA recombination
G3566_RS07825	COG1420	regulation of RNA biosynthetic process
G3566_RS07830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G3566_RS07835	COG0443	Heat shock 70 kDa protein
G3566_RS07840	COG0484	heat shock protein binding
G3566_RS07845	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G3566_RS07875	COG0583	DNA-binding transcription factor activity
G3566_RS07880	COG1132	(ABC) transporter
G3566_RS07905	COG0567	Dehydrogenase, E1 component
G3566_RS07915	COG2850	peptidyl-arginine hydroxylation
G3566_RS07935	COG1253	flavin adenine dinucleotide binding
G3566_RS07965	COG1131	(ABC) transporter
G3566_RS07970	COG1725	Transcriptional regulator
G3566_RS07980	COG0386	Belongs to the glutathione peroxidase family
G3566_RS07995	COG2900	Belongs to the SlyX family
G3566_RS08020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G3566_RS08030	COG0646	methionine synthase
G3566_RS08030	COG1410	methionine synthase
G3566_RS08035	COG1410	methionine synthase
G3566_RS08035	COG0646	methionine synthase
G3566_RS08040	COG2226	methyltransferase
G3566_RS08045	COG1960	acyl-CoA dehydrogenase activity
G3566_RS08050	COG1960	acyl-CoA dehydrogenase activity
G3566_RS08080	COG0557	exoribonuclease II activity
G3566_RS08090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G3566_RS08100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G3566_RS08110	COG0704	Plays a role in the regulation of phosphate uptake
G3566_RS08115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G3566_RS08120	COG0581	inorganic phosphate transmembrane transporter activity
G3566_RS08125	COG0573	inorganic phosphate transmembrane transporter activity
G3566_RS08130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G3566_RS08155	COG0659	secondary active sulfate transmembrane transporter activity
G3566_RS08160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G3566_RS08170	COG1024	Enoyl-CoA hydratase
G3566_RS08180	COG0494	nUDIX hydrolase
G3566_RS08225	COG0116	Belongs to the methyltransferase superfamily
G3566_RS08225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G3566_RS08230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G3566_RS08255	COG2925	Exonuclease
G3566_RS08260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3566_RS08265	COG3844	kynureninase activity
G3566_RS08275	COG0662	Cupin 2, conserved barrel domain protein
G3566_RS08280	COG0288	reversible hydration of carbon dioxide
G3566_RS08360	COG0017	Asparaginyl-tRNA synthetase
G3566_RS08365	COG0316	Belongs to the HesB IscA family
G3566_RS08370	COG0360	Binds together with S18 to 16S ribosomal RNA
G3566_RS08375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G3566_RS08380	COG0359	binds to the 23S rRNA
G3566_RS08395	COG3115	cell septum assembly
G3566_RS08405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G3566_RS08410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G3566_RS08415	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
G3566_RS08425	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
G3566_RS08435	COG4993	Dehydrogenase
G3566_RS08445	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G3566_RS08455	COG2986	histidine ammonia-lyase
G3566_RS08460	COG1228	amidohydrolase
G3566_RS08495	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
G3566_RS08500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G3566_RS08505	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G3566_RS08510	COG0077	Prephenate dehydratase
G3566_RS08510	COG1605	Chorismate mutase
G3566_RS08515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G3566_RS08530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G3566_RS08535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G3566_RS08540	COG0583	DNA-binding transcription factor activity
G3566_RS08555	COG0840	transmembrane signaling receptor activity
G3566_RS08580	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
G3566_RS08585	COG4191	Histidine kinase
G3566_RS08585	COG0784	Response regulator, receiver
G3566_RS08600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3566_RS08610	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
G3566_RS08620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G3566_RS08635	COG1595	DNA-templated transcription, initiation
G3566_RS08685	COG2244	polysaccharide biosynthetic process
G3566_RS08715	COG2264	protein methyltransferase activity
G3566_RS08740	COG1136	(ABC) transporter
G3566_RS08750	COG0477	Major facilitator Superfamily
G3566_RS08755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3566_RS08770	COG1253	flavin adenine dinucleotide binding
G3566_RS08780	COG0306	phosphate transporter
G3566_RS08805	COG0504	CTP synthase activity
G3566_RS08820	COG0148	phosphopyruvate hydratase activity
G3566_RS08825	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G3566_RS08830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G3566_RS08835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G3566_RS08840	COG0585	pseudouridine synthase activity
G3566_RS08845	COG2840	Smr protein MutS2
G3566_RS08850	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G3566_RS08855	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G3566_RS08860	COG1238	metal cluster binding
G3566_RS08875	COG1534	Rna-binding protein
G3566_RS08880	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G3566_RS08890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G3566_RS08895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G3566_RS08905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G3566_RS08910	COG1546	Belongs to the CinA family
G3566_RS08920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G3566_RS08925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G3566_RS08930	COG2137	regulation of response to DNA damage stimulus
G3566_RS08935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G3566_RS08940	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G3566_RS08955	COG1741	Belongs to the pirin family
G3566_RS08960	COG0583	DNA-binding transcription factor activity
G3566_RS08985	COG0351	phosphomethylpyrimidine kinase
G3566_RS09000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G3566_RS09005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G3566_RS09020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3566_RS09030	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G3566_RS09035	COG3734	2-keto-3-deoxy-galactonokinase
G3566_RS09045	COG4948	Mandelate Racemase Muconate Lactonizing
G3566_RS09050	COG0800	Aldolase
G3566_RS09085	COG1501	Belongs to the glycosyl hydrolase 31 family
G3566_RS09095	COG1070	Carbohydrate kinase
G3566_RS09100	COG2115	Belongs to the xylose isomerase family
G3566_RS09105	COG0477	Major facilitator Superfamily
G3566_RS09120	COG0860	N-Acetylmuramoyl-L-alanine amidase
G3566_RS09125	COG1469	GTP cyclohydrolase I activity
G3566_RS09135	COG0617	tRNA 3'-terminal CCA addition
G3566_RS09145	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G3566_RS09150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G3566_RS09155	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G3566_RS09180	COG1472	Belongs to the glycosyl hydrolase 3 family
G3566_RS09190	COG5001	Diguanylate cyclase
G3566_RS09190	COG4251	negative regulation of phosphorylation
G3566_RS09190	COG3706	GGDEF domain
G3566_RS09190	COG2203	Gaf domain
G3566_RS09195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
G3566_RS09200	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G3566_RS09210	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G3566_RS09215	COG0671	phosphoesterase, PA-phosphatase related
G3566_RS09230	COG1794	racemase activity, acting on amino acids and derivatives
G3566_RS09235	COG0697	spore germination
G3566_RS09240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G3566_RS09245	COG0167	dihydroorotate dehydrogenase activity
G3566_RS09265	COG1012	belongs to the aldehyde dehydrogenase family
G3566_RS09300	COG1215	transferase activity, transferring glycosyl groups
G3566_RS09305	COG0726	polysaccharide deacetylase
G3566_RS09305	COG1649	PFAM Uncharacterised BCR, COG1649
G3566_RS09400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3566_RS09405	COG0124	histidyl-tRNA synthetase
G3566_RS09415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G3566_RS09420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G3566_RS09425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G3566_RS09430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G3566_RS09430	COG0131	Imidazoleglycerol-phosphate dehydratase
G3566_RS09435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G3566_RS09440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G3566_RS09445	COG0107	imidazoleglycerol-phosphate synthase activity
G3566_RS09450	COG0140	phosphoribosyl-ATP diphosphatase activity
G3566_RS09450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G3566_RS09465	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
G3566_RS09470	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
G3566_RS09475	COG0235	Class ii aldolase
G3566_RS09480	COG0531	amino acid
G3566_RS09485	COG0531	amino acid
G3566_RS09495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3566_RS09500	COG0277	FAD linked oxidase domain protein
G3566_RS09520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G3566_RS09565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3566_RS09570	COG2258	MOSC domain
G3566_RS09575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G3566_RS09580	COG0505	Belongs to the CarA family
G3566_RS09590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G3566_RS09595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G3566_RS09605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G3566_RS09665	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G3566_RS09675	COG2205	protein histidine kinase activity
G3566_RS09675	COG2198	Histidine kinase
G3566_RS09675	COG0784	Response regulator, receiver
G3566_RS09680	COG2198	Histidine kinase
G3566_RS09680	COG0784	Response regulator, receiver
G3566_RS09680	COG2205	protein histidine kinase activity
G3566_RS09685	COG1024	Enoyl-CoA hydratase
G3566_RS09690	COG0318	PFAM AMP-dependent synthetase and ligase
G3566_RS09700	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G3566_RS09725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3566_RS09735	COG2201	protein-glutamate methylesterase activity
G3566_RS09740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G3566_RS09750	COG0840	transmembrane signaling receptor activity
G3566_RS09765	COG0835	chemotaxis
G3566_RS09785	COG0840	transmembrane signaling receptor activity
G3566_RS09790	COG0840	transmembrane signaling receptor activity
G3566_RS09800	COG0840	transmembrane signaling receptor activity
G3566_RS09810	COG0840	transmembrane signaling receptor activity
G3566_RS09815	COG0840	transmembrane signaling receptor activity
G3566_RS09820	COG0840	transmembrane signaling receptor activity
G3566_RS09825	COG0840	transmembrane signaling receptor activity
G3566_RS09835	COG0840	transmembrane signaling receptor activity
G3566_RS09860	COG0745	RESPONSE REGULATOR receiver
G3566_RS09870	COG0835	chemotaxis
G3566_RS09880	COG1360	Flagellar Motor Protein
G3566_RS09885	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G3566_RS09935	COG2198	Histidine kinase
G3566_RS09935	COG0784	Response regulator, receiver
G3566_RS09935	COG0643	Histidine kinase
G3566_RS09965	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G3566_RS09990	COG1684	flagellar biosynthetic protein fliR
G3566_RS10005	COG3190	flagellar
G3566_RS10055	COG1677	Flagellar hook-basal body complex protein FliE
G3566_RS10105	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS10110	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS10115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G3566_RS10135	COG2201	protein-glutamate methylesterase activity
G3566_RS10165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
G3566_RS10175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G3566_RS10180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G3566_RS10190	COG1705	Flagellar rod assembly protein muramidase FlgJ
G3566_RS10190	COG3951	Flagellar rod assembly protein muramidase FlgJ
G3566_RS10195	COG1706	bacterial-type flagellum-dependent cell motility
G3566_RS10200	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G3566_RS10210	COG4787	bacterial-type flagellum-dependent cell motility
G3566_RS10220	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G3566_RS10225	COG1558	bacterial-type flagellum-dependent cell motility
G3566_RS10235	COG0784	Response regulator, receiver
G3566_RS10235	COG0835	chemotaxis
G3566_RS10255	COG5002	protein histidine kinase activity
G3566_RS10285	COG2915	High frequency lysogenization protein hflD homolog
G3566_RS10290	COG0482	sulfurtransferase activity
G3566_RS10305	COG0542	response to heat
G3566_RS10315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G3566_RS10325	COG0492	ferredoxin-NADP+ reductase activity
G3566_RS10330	COG1674	ftsk spoiiie
G3566_RS10340	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G3566_RS10350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G3566_RS10355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G3566_RS10360	COG0183	Belongs to the thiolase family
G3566_RS10365	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3566_RS10365	COG1024	Enoyl-CoA hydratase
G3566_RS10380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G3566_RS10390	COG1426	Protein conserved in bacteria
G3566_RS10400	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G3566_RS10405	COG1160	GTP binding
G3566_RS10410	COG0303	'Molybdopterin
G3566_RS10415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G3566_RS10460	COG0303	'Molybdopterin
G3566_RS10465	COG0746	molybdenum cofactor guanylyltransferase activity
G3566_RS10495	COG1914	H( )-stimulated, divalent metal cation uptake system
G3566_RS10515	COG0668	transmembrane transport
G3566_RS10525	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G3566_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS10545	COG1183	phosphatidylcholine synthase activity
G3566_RS10555	COG3243	poly(R)-hydroxyalkanoic acid synthase
G3566_RS10570	COG0723	plastoquinol--plastocyanin reductase activity
G3566_RS10570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3566_RS10580	COG2183	response to ionizing radiation
G3566_RS10585	COG2205	protein histidine kinase activity
G3566_RS10585	COG0784	Response regulator, receiver
G3566_RS10650	COG0800	Aldolase
G3566_RS10655	COG0129	dihydroxy-acid dehydratase activity
G3566_RS10660	COG0363	glucosamine-6-phosphate deaminase activity
G3566_RS10665	COG0837	glucose binding
G3566_RS10670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G3566_RS10680	COG0354	folic acid binding
G3566_RS10695	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G3566_RS10710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G3566_RS10715	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G3566_RS10725	COG4591	ABC-type transport system involved in lipoprotein release permease component
G3566_RS10730	COG1136	(ABC) transporter
G3566_RS10745	COG0811	peptide transport
G3566_RS10750	COG0848	biopolymer transport protein
G3566_RS10755	COG1132	(ABC) transporter
G3566_RS10760	COG1663	tetraacyldisaccharide 4'-kinase activity
G3566_RS10765	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G3566_RS10770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G3566_RS10780	COG0322	excinuclease ABC activity
G3566_RS10785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G3566_RS10805	COG0582	viral genome integration into host DNA
G3566_RS10825	COG2910	NAD(P)H-binding
G3566_RS10835	COG1234	tRNA 3'-trailer cleavage
G3566_RS10845	COG1396	sequence-specific DNA binding
G3566_RS10850	COG0583	DNA-binding transcription factor activity
G3566_RS10865	COG1733	regulation of RNA biosynthetic process
G3566_RS10925	COG3608	succinylglutamate desuccinylase aspartoacylase
G3566_RS10925	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G3566_RS10930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3566_RS10935	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G3566_RS10940	COG2080	2 iron, 2 sulfur cluster binding
G3566_RS10950	COG2133	pyrroloquinoline quinone binding
G3566_RS10965	COG3246	L-lysine catabolic process to acetate
G3566_RS11025	COG2003	Belongs to the UPF0758 family
G3566_RS11250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G3566_RS11255	COG0629	single-stranded DNA binding
G3566_RS11310	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G3566_RS11330	COG1054	Belongs to the UPF0176 family
G3566_RS11340	COG1530	ribonuclease E activity
G3566_RS11350	COG3064	Membrane
G3566_RS11355	COG0428	transporter
G3566_RS11365	COG2154	pterin-4-alpha-carbinolamine dehydratase
G3566_RS11370	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G3566_RS11370	COG0316	Belongs to the HesB IscA family
G3566_RS11415	COG2226	methyltransferase
G3566_RS11415	COG1073	alpha beta
G3566_RS11435	COG4644	lycopene metabolic process
G3566_RS11470	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS11580	COG1408	metallophosphoesterase
G3566_RS11585	COG1064	alcohol dehydrogenase
G3566_RS11590	COG0667	Aldo Keto reductase
G3566_RS11640	COG0667	Aldo Keto reductase
G3566_RS11695	COG4644	lycopene metabolic process
G3566_RS11715	COG3920	Histidine kinase
G3566_RS11725	COG1238	metal cluster binding
G3566_RS11755	COG3279	Response regulator of the LytR AlgR family
G3566_RS11760	COG3275	phosphorelay sensor kinase activity
G3566_RS11795	COG4566	intracellular signal transduction
G3566_RS11805	COG5001	Diguanylate cyclase
G3566_RS11825	COG3685	Protein conserved in bacteria
G3566_RS11840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G3566_RS11840	COG1648	precorrin-2 dehydrogenase activity
G3566_RS11855	COG2814	Major facilitator Superfamily
G3566_RS11870	COG1335	isochorismatase
G3566_RS11885	COG2197	response regulator
G3566_RS11900	COG0583	DNA-binding transcription factor activity
G3566_RS11905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G3566_RS11910	COG3002	Belongs to the UPF0753 family
G3566_RS11915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G3566_RS11915	COG0519	Catalyzes the synthesis of GMP from XMP
G3566_RS11925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G3566_RS11935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G3566_RS11935	COG0475	glutathione-regulated potassium exporter activity
G3566_RS11940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G3566_RS11950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G3566_RS11955	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G3566_RS11965	COG0776	regulation of translation
G3566_RS11970	COG0539	negative regulation of cytoplasmic translation
G3566_RS11975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G3566_RS11990	COG2957	Belongs to the agmatine deiminase family
G3566_RS11995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G3566_RS12020	COG0395	ABC-type sugar transport system, permease component
G3566_RS12025	COG1175	transmembrane transport
G3566_RS12055	COG2350	Protein conserved in bacteria
G3566_RS12060	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G3566_RS12065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G3566_RS12070	COG1187	pseudouridine synthase activity
G3566_RS12090	COG0436	Aminotransferase
G3566_RS12095	COG4133	protoheme IX ABC transporter activity
G3566_RS12115	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
G3566_RS12120	COG1138	Cytochrome C-type biogenesis protein
G3566_RS12140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3566_RS12145	COG1278	Cold shock
G3566_RS12150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G3566_RS12155	COG4988	ABC transporter
G3566_RS12165	COG1294	oxidase, subunit
G3566_RS12195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G3566_RS12200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G3566_RS12210	COG0165	Argininosuccinate lyase
G3566_RS12215	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G3566_RS12225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G3566_RS12230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3566_RS12240	COG0137	argininosuccinate synthase activity
G3566_RS12245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G3566_RS12255	COG0215	cysteine-tRNA ligase activity
G3566_RS12260	COG2166	iron-sulfur cluster assembly
G3566_RS12275	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G3566_RS12280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G3566_RS12300	COG4302	ethanolamine ammonia-lyase activity
G3566_RS12355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G3566_RS12360	COG0402	S-adenosylhomocysteine deaminase activity
G3566_RS12370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G3566_RS12375	COG1509	lysine 2,3-aminomutase activity
G3566_RS12380	COG5001	Diguanylate cyclase
G3566_RS12380	COG3300	MHYT domain
G3566_RS12395	COG0483	inositol monophosphate 1-phosphatase activity
G3566_RS12400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G3566_RS12415	COG0488	(ABC) transporter
G3566_RS12420	COG0513	Belongs to the DEAD box helicase family
G3566_RS12425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G3566_RS12430	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G3566_RS12440	COG0625	glutathione transferase activity
G3566_RS12450	COG4681	YaeQ
G3566_RS12455	COG2081	HI0933 family
G3566_RS12465	COG0501	Belongs to the peptidase M48B family
G3566_RS12470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3566_RS12475	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS12500	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G3566_RS12505	COG0860	N-Acetylmuramoyl-L-alanine amidase
G3566_RS12510	COG0802	atpase or kinase
G3566_RS12515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G3566_RS12515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G3566_RS12520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G3566_RS12525	COG1570	exodeoxyribonuclease VII activity
G3566_RS12535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G3566_RS12580	COG0835	chemotaxis
G3566_RS12585	COG0840	transmembrane signaling receptor activity
G3566_RS12590	COG2094	Belongs to the DNA glycosylase MPG family
G3566_RS12595	COG1201	RNA secondary structure unwinding
G3566_RS12615	COG2969	positive regulation of protein catabolic process
G3566_RS12620	COG0625	glutathione transferase activity
G3566_RS12625	COG2857	Cytochrome c1
G3566_RS12630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G3566_RS12635	COG0723	plastoquinol--plastocyanin reductase activity
G3566_RS12640	COG0741	lytic transglycosylase activity
G3566_RS12655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G3566_RS12660	COG1702	phosphate starvation-inducible protein PhoH
G3566_RS12670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G3566_RS12680	COG4535	Mg2 and Co2 transporter CorC
G3566_RS12695	COG1012	belongs to the aldehyde dehydrogenase family
G3566_RS12700	COG1177	transmembrane transport
G3566_RS12705	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3566_RS12715	COG3842	ATPase activity
G3566_RS12735	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G3566_RS12750	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G3566_RS12755	COG0174	glutamine synthetase
G3566_RS12760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3566_RS12770	COG2703	oxygen carrier activity
G3566_RS12775	COG0477	Major facilitator Superfamily
G3566_RS12785	COG0243	molybdopterin cofactor binding
G3566_RS12790	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G3566_RS12795	COG2223	nitrite transmembrane transporter activity
G3566_RS12800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G3566_RS12810	COG2733	membrane
G3566_RS12815	COG2205	protein histidine kinase activity
G3566_RS12815	COG5002	protein histidine kinase activity
G3566_RS12815	COG0784	Response regulator, receiver
G3566_RS12830	COG0477	Major facilitator Superfamily
G3566_RS12860	COG2902	Dehydrogenase
G3566_RS12870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3566_RS12875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3566_RS12880	COG1609	Transcriptional regulator
G3566_RS12885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G3566_RS12885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3566_RS12890	COG1105	Belongs to the carbohydrate kinase PfkB family
G3566_RS12895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G3566_RS12895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G3566_RS12915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G3566_RS12925	COG1862	Preprotein translocase
G3566_RS12930	COG0343	queuine tRNA-ribosyltransferase activity
G3566_RS12935	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G3566_RS12990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G3566_RS12995	COG3291	Pkd domain containing protein
G3566_RS13000	COG0405	Gamma-glutamyltransferase
G3566_RS13005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G3566_RS13015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G3566_RS13020	COG0742	ribosomal rna small subunit methyltransferase
G3566_RS13025	COG0326	Molecular chaperone. Has ATPase activity
G3566_RS13120	COG0531	amino acid
G3566_RS13135	COG0006	proline dipeptidase activity
G3566_RS13145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3566_RS13160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3566_RS13165	COG3938	Belongs to the proline racemase family
G3566_RS13175	COG0552	protein localization to endoplasmic reticulum
G3566_RS13180	COG1194	a g-specific adenine glycosylase
G3566_RS13185	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G3566_RS13190	COG0784	Response regulator, receiver
G3566_RS13190	COG4191	Histidine kinase
G3566_RS13205	COG0322	excinuclease ABC activity
G3566_RS13220	COG3040	lipid binding
G3566_RS13230	COG1960	acyl-CoA dehydrogenase activity
G3566_RS13240	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G3566_RS13260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3566_RS13265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3566_RS13270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G3566_RS13295	COG0438	transferase activity, transferring glycosyl groups
G3566_RS13305	COG0438	transferase activity, transferring glycosyl groups
G3566_RS13310	COG0438	transferase activity, transferring glycosyl groups
G3566_RS13360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3566_RS13360	COG0072	phenylalanine-tRNA ligase activity
G3566_RS13365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G3566_RS13380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G3566_RS13385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G3566_RS13400	COG2211	Major facilitator Superfamily
G3566_RS13400	COG2190	(PTS) system
G3566_RS13410	COG1082	Xylose isomerase domain protein TIM barrel
G3566_RS13425	COG0366	Alpha amylase catalytic
G3566_RS13505	COG3702	type iv secretory pathway
G3566_RS13525	COG2948	multi-organism process
G3566_RS13545	COG3505	Type IV secretory pathway VirD4
G3566_RS13560	COG0556	nucleotide-excision repair
G3566_RS13565	COG4969	Belongs to the N-Me-Phe pilin family
G3566_RS13605	COG1611	Belongs to the LOG family
G3566_RS13615	COG2095	MarC family integral membrane protein
G3566_RS13625	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G3566_RS13660	COG1185	polyribonucleotide nucleotidyltransferase activity
G3566_RS13665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G3566_RS13670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G3566_RS13675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G3566_RS13680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G3566_RS13685	COG0195	Participates in both transcription termination and antitermination
G3566_RS13690	COG0779	Required for maturation of 30S ribosomal subunits
G3566_RS13700	COG1007	ATP synthesis coupled electron transport
G3566_RS13725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3566_RS13730	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G3566_RS13740	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G3566_RS13745	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G3566_RS13750	COG0649	NAD binding
G3566_RS13755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3566_RS13760	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3566_RS13765	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3566_RS13780	COG0149	triose-phosphate isomerase activity
G3566_RS13785	COG0300	oxidoreductase activity
G3566_RS13815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G3566_RS13820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G3566_RS13825	COG0159	tryptophan synthase activity
G3566_RS13835	COG0133	tryptophan synthase activity
G3566_RS13845	COG0135	phosphoribosylanthranilate isomerase activity
G3566_RS13850	COG0101	tRNA pseudouridine synthase activity
G3566_RS13865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G3566_RS13870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3566_RS13875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G3566_RS13880	COG2890	protein-(glutamine-N5) methyltransferase activity
G3566_RS13890	COG0688	phosphatidylethanolamine metabolic process
G3566_RS13900	COG0433	COG0433 Predicted ATPase
G3566_RS13905	COG0494	nUDIX hydrolase
G3566_RS13920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G3566_RS13925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G3566_RS13950	COG0717	Belongs to the dCTP deaminase family
G3566_RS13955	COG0489	protein tyrosine kinase activity
G3566_RS13975	COG3590	peptidase
G3566_RS13980	COG3590	peptidase
G3566_RS14000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3566_RS14005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3566_RS14010	COG2311	Membrane
G3566_RS14015	COG1047	Peptidyl-prolyl cis-trans
G3566_RS14020	COG0791	NLP P60 protein
G3566_RS14025	COG0791	NLP P60 protein
G3566_RS14035	COG4106	trans-aconitate 2-methyltransferase activity
G3566_RS14040	COG1301	dicarboxylic acid transport
G3566_RS14045	COG1785	Belongs to the alkaline phosphatase family
G3566_RS14050	COG0037	tRNA processing
G3566_RS14055	COG1722	exodeoxyribonuclease VII activity
G3566_RS14060	COG0142	geranyltranstransferase activity
G3566_RS14065	COG4104	PAAR repeat-containing protein
G3566_RS14075	COG0312	modulator of DNA gyrase
G3566_RS14080	COG3028	Belongs to the UPF0307 family
G3566_RS14085	COG0312	modulator of DNA gyrase
G3566_RS14095	COG3164	Protein of unknown function
G3566_RS14105	COG0424	maF-like protein
G3566_RS14110	COG2968	Membrane
G3566_RS14125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G3566_RS14140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G3566_RS14155	COG0495	leucyl-tRNA aminoacylation
G3566_RS14165	COG3118	belongs to the thioredoxin family
G3566_RS14210	COG2155	Conserved Protein
G3566_RS14255	COG1132	(ABC) transporter
G3566_RS14280	COG1538	Outer membrane efflux protein
G3566_RS14285	COG0745	RESPONSE REGULATOR receiver
G3566_RS14290	COG5000	phosphorelay sensor kinase activity
G3566_RS14290	COG5002	protein histidine kinase activity
G3566_RS14295	COG0475	glutathione-regulated potassium exporter activity
G3566_RS14305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G3566_RS14325	COG1187	pseudouridine synthase activity
G3566_RS14330	COG5001	Diguanylate cyclase
G3566_RS14330	COG5002	protein histidine kinase activity
G3566_RS14340	COG1595	DNA-templated transcription, initiation
G3566_RS14440	COG0667	Aldo Keto reductase
G3566_RS14445	COG2814	Major facilitator Superfamily
G3566_RS14470	COG1309	transcriptional regulator
G3566_RS14480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3566_RS14495	COG0735	belongs to the Fur family
G3566_RS14500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3566_RS14525	COG4452	Inner membrane protein CreD
G3566_RS14535	COG2205	protein histidine kinase activity
G3566_RS14540	COG0745	RESPONSE REGULATOR receiver
G3566_RS14545	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G3566_RS14555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G3566_RS14565	COG0643	Histidine kinase
G3566_RS14565	COG2198	Histidine kinase
G3566_RS14570	COG0840	transmembrane signaling receptor activity
G3566_RS14575	COG0835	chemotaxis
G3566_RS14580	COG2199	diguanylate cyclase activity
G3566_RS14580	COG2200	EAL domain
G3566_RS14580	COG2202	Pas domain
G3566_RS14585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G3566_RS14590	COG2201	protein-glutamate methylesterase activity
G3566_RS14595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3566_RS14600	COG3590	peptidase
G3566_RS14610	COG0588	phosphoglycerate mutase activity
G3566_RS14615	COG1515	deoxyribonuclease V activity
G3566_RS14640	COG1741	Belongs to the pirin family
G3566_RS14645	COG1966	Carbon starvation protein
G3566_RS14650	COG2879	small protein
G3566_RS14685	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G3566_RS14690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3566_RS14695	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G3566_RS14700	COG2080	2 iron, 2 sulfur cluster binding
G3566_RS14705	COG3321	synthase
G3566_RS14705	COG0604	alcohol dehydrogenase
G3566_RS14705	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS14710	COG2203	Gaf domain
G3566_RS14710	COG3706	GGDEF domain
G3566_RS14710	COG4251	negative regulation of phosphorylation
G3566_RS14710	COG5001	Diguanylate cyclase
G3566_RS14715	COG0629	single-stranded DNA binding
G3566_RS14720	COG0142	geranyltranstransferase activity
G3566_RS14735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G3566_RS14750	COG0527	aspartate kinase activity
G3566_RS14755	COG0384	phenazine biosynthesis protein PhzF
G3566_RS14760	COG0384	phenazine biosynthesis protein PhzF
G3566_RS14770	COG1764	response to oxidative stress
G3566_RS14775	COG0540	Belongs to the ATCase OTCase family
G3566_RS14780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G3566_RS14785	COG1678	Uncharacterized ACR, COG1678
G3566_RS14790	COG0519	Catalyzes the synthesis of GMP from XMP
G3566_RS14815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G3566_RS14830	COG0739	heme binding
G3566_RS14850	COG0693	protein deglycase activity
G3566_RS14860	COG1959	2 iron, 2 sulfur cluster binding
G3566_RS14865	COG0719	Fe-S assembly protein
G3566_RS14870	COG0396	ATPase activity
G3566_RS14875	COG0719	Fe-S assembly protein
G3566_RS14880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G3566_RS14890	COG2146	nitrite reductase [NAD(P)H] activity
G3566_RS14900	COG3128	pkhd-type hydroxylase
G3566_RS14925	COG1477	protein flavinylation
G3566_RS14930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G3566_RS14940	COG1555	photosystem II stabilization
G3566_RS14955	COG3178	'Phosphotransferase
G3566_RS14960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G3566_RS14970	COG0628	permease
G3566_RS14980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G3566_RS14990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G3566_RS15010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G3566_RS15015	COG0271	Belongs to the BolA IbaG family
G3566_RS15025	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G3566_RS15035	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G3566_RS15040	COG1137	ATPase activity
G3566_RS15055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3566_RS15060	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G3566_RS15065	COG1660	Displays ATPase and GTPase activities
G3566_RS15075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3566_RS15080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G3566_RS15085	COG2239	Acts as a magnesium transporter
G3566_RS15095	COG1294	oxidase, subunit
G3566_RS15100	COG1271	oxidase subunit
G3566_RS15110	COG1113	amino acid transport
G3566_RS15125	COG2197	response regulator
G3566_RS15130	COG0531	amino acid
G3566_RS15195	COG2814	Major facilitator Superfamily
G3566_RS15205	COG0754	glutathionylspermidine amidase activity
G3566_RS15230	COG1842	Phage shock protein A
G3566_RS15240	COG0259	pyridoxamine-phosphate oxidase activity
G3566_RS15245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G3566_RS15250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G3566_RS15260	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G3566_RS15265	COG2814	Major facilitator Superfamily
G3566_RS15285	COG2205	protein histidine kinase activity
G3566_RS15285	COG2198	Histidine kinase
G3566_RS15285	COG0784	Response regulator, receiver
G3566_RS15290	COG2353	YceI-like domain
G3566_RS15310	COG1760	l-serine dehydratase
G3566_RS15320	COG0527	aspartate kinase activity
G3566_RS15320	COG0460	homoserine dehydrogenase
G3566_RS15325	COG0626	cystathionine gamma-synthase activity
G3566_RS15330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3566_RS15335	COG0739	heme binding
G3566_RS15340	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G3566_RS15345	COG1272	protein, Hemolysin III
G3566_RS15350	COG2982	Protein involved in outer membrane biogenesis
G3566_RS15355	COG0516	GMP reductase activity
G3566_RS15355	COG0517	IMP dehydrogenase activity
G3566_RS15360	COG0463	Glycosyl transferase, family 2
G3566_RS15365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G3566_RS15370	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G3566_RS15380	COG4771	TonB-dependent receptor
G3566_RS15390	COG1309	transcriptional regulator
G3566_RS15400	COG1960	acyl-CoA dehydrogenase activity
G3566_RS15430	COG0509	glycine decarboxylation via glycine cleavage system
G3566_RS15435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G3566_RS15455	COG1742	UPF0060 membrane protein
G3566_RS15460	COG3956	TIGRFAM MazG family protein
G3566_RS15465	COG1218	3'(2'),5'-bisphosphate nucleotidase
G3566_RS15470	COG0494	nUDIX hydrolase
G3566_RS15480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G3566_RS15485	COG0837	glucose binding
G3566_RS15500	COG3858	chitin binding
G3566_RS15500	COG1388	LysM domain
G3566_RS15505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G3566_RS15515	COG1472	Belongs to the glycosyl hydrolase 3 family
G3566_RS15530	COG0531	amino acid
G3566_RS15540	COG1486	melibiose metabolic process
G3566_RS15550	COG3537	Alpha-1,2-mannosidase
G3566_RS15585	COG3142	Participates in the control of copper homeostasis
G3566_RS15590	COG1446	asparaginase
G3566_RS15610	COG0643	Histidine kinase
G3566_RS15610	COG0784	Response regulator, receiver
G3566_RS15610	COG2198	Histidine kinase
G3566_RS15615	COG0840	transmembrane signaling receptor activity
G3566_RS15620	COG0835	chemotaxis
G3566_RS15635	COG0189	ligase activity
G3566_RS15645	COG1397	ADP-ribosylglycohydrolase
G3566_RS15655	COG1199	ATP-dependent helicase activity
G3566_RS15665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G3566_RS15670	COG1216	Glycosyl transferase, family 2
G3566_RS15670	COG1442	glycosyl transferase family 8
G3566_RS15680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G3566_RS15690	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G3566_RS15695	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
G3566_RS15700	COG0535	radical SAM domain protein
G3566_RS15705	COG0535	radical SAM domain protein
G3566_RS15720	COG0837	glucose binding
G3566_RS15730	COG1643	Atp-dependent helicase
G3566_RS15735	COG0783	Belongs to the Dps family
G3566_RS15740	COG0514	ATP-dependent DNA helicase (RecQ)
G3566_RS15775	COG0840	transmembrane signaling receptor activity
G3566_RS15795	COG3920	Histidine kinase
G3566_RS15800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G3566_RS15810	COG0602	queuosine metabolic process
G3566_RS15820	COG2885	chlorophyll binding
G3566_RS15825	COG0823	Involved in the tonB-independent uptake of proteins
G3566_RS15835	COG0848	biopolymer transport protein
G3566_RS15845	COG0824	Thioesterase
G3566_RS15850	COG2255	four-way junction helicase activity
G3566_RS15855	COG3158	transport of potassium into the cell
G3566_RS15860	COG0632	four-way junction helicase activity
G3566_RS15865	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G3566_RS15870	COG0217	transcriptional regulatory protein
G3566_RS15885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G3566_RS15900	COG0477	Major facilitator Superfamily
G3566_RS15940	COG0488	(ABC) transporter
G3566_RS15970	COG4651	solute:proton antiporter activity
G3566_RS15970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G3566_RS15980	COG4772	TonB-dependent receptor
G3566_RS15990	COG4264	IucA IucC family
G3566_RS16005	COG0019	diaminopimelate decarboxylase activity
G3566_RS16035	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G3566_RS16045	COG1492	cobalamin metabolic process
G3566_RS16055	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G3566_RS16080	COG4206	TonB-dependent receptor
G3566_RS16085	COG0542	response to heat
G3566_RS16090	COG1116	anion transmembrane transporter activity
G3566_RS16095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3566_RS16100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3566_RS16105	COG0667	Aldo Keto reductase
G3566_RS16110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3566_RS16115	COG4771	TonB-dependent receptor
G3566_RS16120	COG2827	Endonuclease containing a URI domain
G3566_RS16160	COG1877	trehalose-phosphatase activity
G3566_RS16165	COG3387	PFAM Glycoside hydrolase 15-related
G3566_RS16180	COG0840	transmembrane signaling receptor activity
G3566_RS16185	COG3011	Protein conserved in bacteria
G3566_RS16200	COG0564	pseudouridine synthase activity
G3566_RS16205	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G3566_RS16215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G3566_RS16215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G3566_RS16230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G3566_RS16235	COG0045	succinate-CoA ligase (ADP-forming) activity
G3566_RS16255	COG4969	Belongs to the N-Me-Phe pilin family
G3566_RS16270	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G3566_RS16275	COG0237	dephospho-CoA kinase activity
G3566_RS16295	COG0745	RESPONSE REGULATOR receiver
G3566_RS16305	COG0189	ligase activity
G3566_RS16345	COG2022	thiamine diphosphate biosynthetic process
G3566_RS16350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G3566_RS16355	COG0471	metal ion transport
G3566_RS16355	COG3273	potassium ion transport
G3566_RS16375	COG1970	mechanosensitive ion channel activity
G3566_RS16385	COG1609	Transcriptional regulator
G3566_RS16395	COG3250	beta-galactosidase activity
G3566_RS16400	COG4948	Mandelate Racemase Muconate Lactonizing
G3566_RS16415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G3566_RS16425	COG0308	aminopeptidase N
G3566_RS16455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3566_RS16465	COG0529	Catalyzes the synthesis of activated sulfate
G3566_RS16465	COG2895	sulfate adenylyltransferase (ATP) activity
G3566_RS16470	COG0175	sulfate reduction
G3566_RS16475	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G3566_RS16480	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3566_RS16485	COG0175	sulfate reduction
G3566_RS16495	COG4774	siderophore transport
G3566_RS16505	COG2205	protein histidine kinase activity
G3566_RS16505	COG0784	Response regulator, receiver
G3566_RS16505	COG2198	Histidine kinase
G3566_RS16535	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G3566_RS16540	COG3588	fructose-bisphosphate aldolase
G3566_RS16545	COG0469	pyruvate kinase activity
G3566_RS16555	COG0126	phosphoglycerate kinase activity
G3566_RS16575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G3566_RS16585	COG3047	cAMP biosynthetic process
G3566_RS16590	COG3047	cAMP biosynthetic process
G3566_RS16600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3566_RS16600	COG3453	Protein conserved in bacteria
G3566_RS16605	COG0725	ABC transporter, periplasmic molybdate-binding protein
G3566_RS16610	COG4149	molybdate abc transporter
G3566_RS16615	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G3566_RS16650	COG1376	ErfK ybiS ycfS ynhG family protein
G3566_RS16655	COG0739	heme binding
G3566_RS16660	COG4773	Receptor
G3566_RS16665	COG0596	Alpha beta hydrolase
G3566_RS16670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G3566_RS16675	COG1301	dicarboxylic acid transport
G3566_RS16685	COG2304	oxidoreductase activity
G3566_RS16705	COG0714	Associated with various cellular activities
G3566_RS16735	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G3566_RS16760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G3566_RS16770	COG2721	sulfolactate sulfo-lyase activity
G3566_RS16785	COG2271	Major facilitator Superfamily
G3566_RS16800	COG0583	DNA-binding transcription factor activity
G3566_RS16805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G3566_RS16820	COG1561	YicC-like family, N-terminal region
G3566_RS16825	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G3566_RS16835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G3566_RS16840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G3566_RS16855	COG0006	proline dipeptidase activity
G3566_RS16865	COG0006	proline dipeptidase activity
G3566_RS16870	COG3079	Belongs to the UPF0149 family
G3566_RS16890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G3566_RS16900	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G3566_RS16910	COG2912	Transglutaminase-like superfamily
G3566_RS16915	COG1773	rubredoxin
G3566_RS16920	COG0352	thiamine-phosphate diphosphorylase activity
G3566_RS16935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G3566_RS16950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G3566_RS16980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G3566_RS16985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3566_RS16990	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS17000	COG0671	phosphoesterase, PA-phosphatase related
G3566_RS17005	COG3781	membrane
G3566_RS17015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G3566_RS17020	COG0563	adenylate kinase activity
G3566_RS17035	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G3566_RS17045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G3566_RS17065	COG3710	Transcriptional regulator
G3566_RS17070	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G3566_RS17080	COG0840	transmembrane signaling receptor activity
G3566_RS17085	COG0405	Gamma-glutamyltransferase
G3566_RS17090	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G3566_RS17110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3566_RS17115	COG0473	3-isopropylmalate dehydrogenase activity
G3566_RS17120	COG0066	3-isopropylmalate dehydratase activity
G3566_RS17125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G3566_RS17145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G3566_RS17150	COG1538	Outer membrane efflux protein
G3566_RS17155	COG1519	Transferase
G3566_RS17160	COG1560	Kdo2-lipid A biosynthetic process
G3566_RS17215	COG0281	malic enzyme
G3566_RS17215	COG0280	phosphate acetyltransferase
G3566_RS17220	COG1301	dicarboxylic acid transport
G3566_RS17245	COG0583	DNA-binding transcription factor activity
G3566_RS17250	COG0667	Aldo Keto reductase
G3566_RS17265	COG2197	response regulator
G3566_RS17275	COG0642	Histidine kinase
G3566_RS17290	COG2851	Citrate transporter
G3566_RS17295	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS17300	COG1609	Transcriptional regulator
G3566_RS17305	COG2211	Major facilitator Superfamily
G3566_RS17335	COG1162	GTPase activity
G3566_RS17370	COG0436	Aminotransferase
G3566_RS17385	COG0726	polysaccharide deacetylase
G3566_RS17390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G3566_RS17405	COG3964	amidohydrolase
G3566_RS17410	COG0402	S-adenosylhomocysteine deaminase activity
G3566_RS17430	COG1307	EDD domain protein, DegV family
G3566_RS17435	COG0242	peptide deformylase activity
G3566_RS17455	COG0457	Tetratricopeptide repeat
G3566_RS17460	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
G3566_RS17465	COG1215	transferase activity, transferring glycosyl groups
G3566_RS17470	COG1215	transferase activity, transferring glycosyl groups
G3566_RS17485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G3566_RS17530	COG2188	Transcriptional regulator
G3566_RS17540	COG1450	Type ii and iii secretion system protein
G3566_RS17555	COG3166	PFAM Fimbrial assembly family protein
G3566_RS17560	COG3156	type II secretion system protein K
G3566_RS17565	COG4795	General secretion pathway protein
G3566_RS17570	COG2165	general secretion pathway protein
G3566_RS17575	COG4970	Tfp pilus assembly protein FimT
G3566_RS17580	COG2165	general secretion pathway protein
G3566_RS17585	COG1459	type II secretion system
G3566_RS17590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G3566_RS17595	COG1404	Belongs to the peptidase S8 family
G3566_RS17600	COG5295	Hep Hag repeat protein
G3566_RS17605	COG1404	Belongs to the peptidase S8 family
G3566_RS17610	COG5295	Hep Hag repeat protein
G3566_RS17615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G3566_RS17615	COG0047	phosphoribosylformylglycinamidine synthase activity
G3566_RS17620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G3566_RS17625	COG4974	Belongs to the 'phage' integrase family
G3566_RS17640	COG0795	lipopolysaccharide-transporting ATPase activity
G3566_RS17650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G3566_RS17665	COG0525	valine-tRNA ligase activity
G3566_RS17680	COG0741	lytic transglycosylase activity
G3566_RS17705	COG1183	phosphatidylcholine synthase activity
G3566_RS17715	COG0442	prolyl-tRNA aminoacylation
G3566_RS17730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G3566_RS17735	COG1127	ABC transporter
G3566_RS17740	COG3218	ABC-type transport auxiliary lipoprotein component
G3566_RS17740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G3566_RS17770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G3566_RS17775	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
G3566_RS17775	COG0662	Cupin 2, conserved barrel domain protein
G3566_RS17805	COG2086	electron transfer activity
G3566_RS17820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G3566_RS17820	COG0546	phosphoglycolate phosphatase activity
G3566_RS17825	COG0277	FAD linked oxidase domain protein
G3566_RS17835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3566_RS17865	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
G3566_RS17870	COG0438	transferase activity, transferring glycosyl groups
G3566_RS17890	COG0438	transferase activity, transferring glycosyl groups
G3566_RS17900	COG0626	cystathionine gamma-synthase activity
G3566_RS17930	COG0625	glutathione transferase activity
G3566_RS17940	COG0513	Belongs to the DEAD box helicase family
G3566_RS17950	COG4771	TonB-dependent receptor
G3566_RS17955	COG0720	synthase
G3566_RS17975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G3566_RS17980	COG1956	GAF domain-containing protein
G3566_RS17990	COG2819	hydrolase of the alpha beta superfamily
G3566_RS18000	COG0546	phosphoglycolate phosphatase activity
G3566_RS18005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G3566_RS18010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3566_RS18025	COG0339	signal peptide processing
G3566_RS18075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G3566_RS18080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3566_RS18085	COG1136	(ABC) transporter
G3566_RS18090	COG0577	efflux transmembrane transporter activity
G3566_RS18095	COG0577	efflux transmembrane transporter activity
G3566_RS18095	COG1136	(ABC) transporter
G3566_RS18110	COG4191	Histidine kinase
G3566_RS18115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G3566_RS18130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G3566_RS18135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G3566_RS18140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G3566_RS18145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G3566_RS18150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G3566_RS18155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G3566_RS18165	COG0356	it plays a direct role in the translocation of protons across the membrane
G3566_RS18185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3566_RS18195	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3566_RS18230	COG2011	ABC-type metal ion transport system permease component
G3566_RS18235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G3566_RS18240	COG0697	spore germination
G3566_RS18245	COG1666	GTP binding
G3566_RS18255	COG0784	Response regulator, receiver
G3566_RS18255	COG5002	protein histidine kinase activity
G3566_RS18255	COG2198	Histidine kinase
G3566_RS18275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G3566_RS18280	COG1187	pseudouridine synthase activity
G3566_RS18305	COG2202	Pas domain
G3566_RS18305	COG2205	protein histidine kinase activity
G3566_RS18325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G3566_RS18330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3566_RS18385	COG0842	Transport permease protein
G3566_RS18390	COG1131	(ABC) transporter
G3566_RS18395	COG0025	NhaP-type Na H and K H
G3566_RS18400	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
G3566_RS18405	COG1573	uracil-dna glycosylase
G3566_RS18415	COG3384	dioxygenase
G3566_RS18425	COG0583	DNA-binding transcription factor activity
G3566_RS18435	COG0667	Aldo Keto reductase
G3566_RS18445	COG3590	peptidase
G3566_RS18460	COG0531	amino acid
G3566_RS18475	COG2972	Histidine kinase
G3566_RS18490	COG3685	Protein conserved in bacteria
G3566_RS18495	COG3546	catalase activity
G3566_RS18530	COG2204	response regulator
G3566_RS18540	COG1271	oxidase subunit
G3566_RS18545	COG1294	oxidase, subunit
G3566_RS18560	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS18565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G3566_RS18585	COG1132	(ABC) transporter
G3566_RS18600	COG1063	alcohol dehydrogenase
G3566_RS18675	COG0251	oxidation-reduction process
G3566_RS18690	COG0840	transmembrane signaling receptor activity
G3566_RS18705	COG0583	DNA-binding transcription factor activity
G3566_RS18710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G3566_RS18740	COG0659	secondary active sulfate transmembrane transporter activity
G3566_RS18750	COG0024	Methionine aminopeptidase
G3566_RS18785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G3566_RS18860	COG3179	chitinase
G3566_RS19030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G3566_RS19035	COG1490	D-aminoacyl-tRNA deacylase activity
G3566_RS19040	COG1560	Kdo2-lipid A biosynthetic process
G3566_RS19090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G3566_RS19090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G3566_RS19095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G3566_RS19100	COG0242	peptide deformylase activity
G3566_RS19105	COG1652	LysM domain
G3566_RS19110	COG0758	DNA mediated transformation
G3566_RS19130	COG1754	DNA topoisomerase type I activity
G3566_RS19130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G3566_RS19135	COG0009	L-threonylcarbamoyladenylate synthase
G3566_RS19150	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS19160	COG0616	signal peptide processing
G3566_RS19165	COG0534	Mate efflux family protein
G3566_RS19185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G3566_RS19190	COG0625	glutathione transferase activity
G3566_RS19205	COG1252	NADH dehydrogenase
G3566_RS19210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G3566_RS19215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G3566_RS19220	COG2201	protein-glutamate methylesterase activity
G3566_RS19225	COG2177	Part of the ABC transporter FtsEX involved in
G3566_RS19230	COG2884	Cell division ATP-binding protein ftsE
G3566_RS19235	COG0513	Belongs to the DEAD box helicase family
G3566_RS19240	COG3118	belongs to the thioredoxin family
G3566_RS19245	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G3566_RS19250	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
G3566_RS19255	COG0583	DNA-binding transcription factor activity
G3566_RS19275	COG1652	LysM domain
G3566_RS19280	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G3566_RS19280	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G3566_RS19285	COG1473	amidohydrolase
G3566_RS19290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3566_RS19295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3566_RS19315	COG5383	Protein conserved in bacteria
G3566_RS19365	COG4948	Mandelate Racemase Muconate Lactonizing
G3566_RS19375	COG0531	amino acid
G3566_RS19390	COG4682	membrane
G3566_RS19395	COG2133	pyrroloquinoline quinone binding
G3566_RS19405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G3566_RS19410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G3566_RS19420	COG1610	YqeY-like protein
G3566_RS19425	COG1295	ribonuclease BN
G3566_RS19430	COG0358	DNA primase activity
G3566_RS19445	COG0109	protoheme IX farnesyltransferase activity
G3566_RS19475	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
G3566_RS19490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G3566_RS19530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G3566_RS19535	COG0739	heme binding
G3566_RS19540	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G3566_RS19550	COG2223	nitrite transmembrane transporter activity
G3566_RS19560	COG0708	Exodeoxyribonuclease III
G3566_RS19565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G3566_RS19575	COG1192	Involved in chromosome partitioning
G3566_RS19580	COG1475	DNA binding
G3566_RS19595	COG0463	Glycosyl transferase, family 2
G3566_RS19610	COG0756	dUTP diphosphatase activity
G3566_RS19615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G3566_RS19620	COG2003	Belongs to the UPF0758 family
G3566_RS19625	COG0018	arginyl-trna synthetase
G3566_RS19640	COG4221	oxidoreductase activity
G3566_RS19645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G3566_RS19645	COG2755	lipolytic protein G-D-S-L family
G3566_RS19655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G3566_RS19660	COG1166	arginine decarboxylase activity
G3566_RS19665	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G3566_RS19685	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G3566_RS19685	COG3291	Pkd domain containing protein
G3566_RS19700	COG0606	chelatase, subunit chli
G3566_RS19715	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G3566_RS19740	COG1690	Belongs to the RtcB family
G3566_RS19775	COG1090	epimerase
G3566_RS19785	COG0642	Histidine kinase
G3566_RS19805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3566_RS19830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G3566_RS19835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G3566_RS19850	COG0753	catalase activity
G3566_RS19865	COG2197	response regulator
G3566_RS19875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3566_RS19880	COG1136	(ABC) transporter
G3566_RS19905	COG0697	spore germination
G3566_RS19925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3566_RS19930	COG0180	Tryptophanyl-tRNA synthetase
G3566_RS19935	COG3237	CsbD-like
G3566_RS19975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G3566_RS19995	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G3566_RS20040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G3566_RS20060	COG1199	ATP-dependent helicase activity
G3566_RS20075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G3566_RS20145	COG0625	glutathione transferase activity
G3566_RS20180	COG4555	ABC transporter
G3566_RS20190	COG1476	TRANSCRIPTIONal
G3566_RS20210	COG1230	cation diffusion facilitator family transporter
G3566_RS20235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G3566_RS20240	COG1131	(ABC) transporter
G3566_RS20245	COG0842	Transport permease protein
G3566_RS20250	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G3566_RS20280	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G3566_RS20285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G3566_RS20295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G3566_RS20295	COG0045	succinate-CoA ligase (ADP-forming) activity
G3566_RS20295	COG1042	CoA-binding domain protein
G3566_RS20300	COG2239	Acts as a magnesium transporter
G3566_RS20315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G3566_RS20320	COG3387	PFAM Glycoside hydrolase 15-related
G3566_RS20335	COG3100	YcgL domain-containing protein
G3566_RS20340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G3566_RS20350	COG0463	Glycosyl transferase, family 2
G3566_RS20365	COG3039	Transposase
G3566_RS20370	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS20410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3566_RS20425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3566_RS20450	COG0823	Involved in the tonB-independent uptake of proteins
G3566_RS20450	COG4946	Tricorn protease homolog
G3566_RS20450	COG1506	peptidase
G3566_RS20465	COG0408	coproporphyrinogen oxidase activity
G3566_RS20500	COG0515	serine threonine protein kinase
G3566_RS20505	COG0631	protein serine/threonine phosphatase activity
G3566_RS20565	COG1595	DNA-templated transcription, initiation
G3566_RS20675	COG0210	DNA helicase
G3566_RS20685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3566_RS20690	COG0583	DNA-binding transcription factor activity
G3566_RS20695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G3566_RS20705	COG2159	amidohydrolase
G3566_RS20725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3566_RS20745	COG0357	Ribosomal RNA small subunit methyltransferase G
G3566_RS20750	COG3540	Alkaline phosphatase
G3566_RS20760	COG2091	lysine biosynthetic process via aminoadipic acid
G3566_RS20775	COG0708	Exodeoxyribonuclease III
G3566_RS20780	COG1846	Transcriptional regulator
G3566_RS20780	COG1940	carbohydrate kinase activity
G3566_RS20790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3566_RS20800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3566_RS20805	COG3162	membrane
G3566_RS20815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3566_RS20840	COG3507	Belongs to the glycosyl hydrolase 43 family
G3566_RS20860	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS20865	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3566_RS20870	COG4948	Mandelate Racemase Muconate Lactonizing
G3566_RS20875	COG3254	rhamnose metabolic process
G3566_RS20880	COG0738	Major facilitator superfamily
G3566_RS20885	COG1414	Transcriptional regulator
G3566_RS20890	COG1971	Probably functions as a manganese efflux pump
G3566_RS20895	COG2205	protein histidine kinase activity
G3566_RS20905	COG3459	Glycosyltransferase 36 associated
G3566_RS20910	COG2211	Major facilitator Superfamily
G3566_RS20915	COG3265	gluconokinase activity
G3566_RS20920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G3566_RS20945	COG2911	Protein conserved in bacteria
G3566_RS20950	COG0729	surface antigen
G3566_RS20985	COG0752	glycyl-tRNA synthetase alpha subunit
G3566_RS20990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G3566_RS20995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G3566_RS20995	COG0519	Catalyzes the synthesis of GMP from XMP
G3566_RS21005	COG0805	protein transport
G3566_RS21010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3566_RS21015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3566_RS21025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G3566_RS21040	COG2974	May be involved in recombination
G3566_RS21045	COG0037	tRNA processing
G3566_RS21050	COG2115	Belongs to the xylose isomerase family
G3566_RS21060	COG3661	Belongs to the glycosyl hydrolase 67 family
G3566_RS21070	COG4948	Mandelate Racemase Muconate Lactonizing
G3566_RS21080	COG1472	Belongs to the glycosyl hydrolase 3 family
G3566_RS21085	COG0246	Mannitol dehydrogenase
G3566_RS21130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G3566_RS21155	COG3386	PFAM SMP-30 Gluconolaconase
G3566_RS21165	COG3250	beta-galactosidase activity
G3566_RS21170	COG1904	glucuronate isomerase
G3566_RS21175	COG3693	PFAM glycoside hydrolase, family 10
G3566_RS21185	COG3693	PFAM glycoside hydrolase, family 10
G3566_RS21200	COG2211	Major facilitator Superfamily
G3566_RS21260	COG3321	synthase
G3566_RS21260	COG0604	alcohol dehydrogenase
G3566_RS21260	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS21265	COG2937	Belongs to the GPAT DAPAT family
G3566_RS21295	COG0284	orotidine-5'-phosphate decarboxylase activity
G3566_RS21300	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
G3566_RS21305	COG3132	Protein of unknown function, DUF480
G3566_RS21320	COG0210	DNA helicase
G3566_RS21325	COG1435	thymidine kinase activity
G3566_RS21335	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G3566_RS21345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G3566_RS21375	COG3135	benzoate transporter
G3566_RS21395	COG0676	glucose-6-phosphate 1-epimerase activity
G3566_RS21405	COG3012	SEC-C Motif Domain Protein
G3566_RS21410	COG0730	response to heat
G3566_RS21430	COG0302	gtp cyclohydrolase
G3566_RS21445	COG1566	PFAM secretion protein HlyD family protein
G3566_RS21455	COG1289	transmembrane transporter activity
G3566_RS21460	COG0477	Major facilitator Superfamily
G3566_RS21470	COG0583	DNA-binding transcription factor activity
G3566_RS21475	COG4221	oxidoreductase activity
G3566_RS21540	COG0564	pseudouridine synthase activity
G3566_RS21570	COG1309	transcriptional regulator
G3566_RS21580	COG1028	Short-chain dehydrogenase reductase Sdr
G3566_RS21615	COG1074	ATP-dependent DNA helicase activity
G3566_RS21620	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G3566_RS21655	COG1127	ABC transporter
G3566_RS21660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G3566_RS21665	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G3566_RS21680	COG2853	Lipoprotein
G3566_RS21690	COG0386	Belongs to the glutathione peroxidase family
G3566_RS21715	COG0625	glutathione transferase activity
G3566_RS21725	COG0531	amino acid
G3566_RS21730	COG3537	Alpha-1,2-mannosidase
G3566_RS21740	COG3706	GGDEF domain
G3566_RS21745	COG3835	regulator
G3566_RS21750	COG1929	Belongs to the glycerate kinase type-1 family
G3566_RS21755	COG2271	Major facilitator Superfamily
G3566_RS21770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G3566_RS21775	COG0861	Integral membrane protein TerC family
G3566_RS21785	COG0584	glycerophosphoryl diester phosphodiesterase
G3566_RS21800	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G3566_RS21810	COG0706	membrane insertase activity
G3566_RS21815	COG0594	ribonuclease P activity