locus-tag	class	description
H8Z73_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H8Z73_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8Z73_RS00020	COG0187	DNA topoisomerase II activity
H8Z73_RS00030	COG0501	Belongs to the peptidase M48B family
H8Z73_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8Z73_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z73_RS00115	COG0793	Belongs to the peptidase S41A family
H8Z73_RS00120	COG4942	peptidase
H8Z73_RS00130	COG2234	aminopeptidase activity
H8Z73_RS00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z73_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z73_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z73_RS00165	COG1064	alcohol dehydrogenase
H8Z73_RS00175	COG0493	'glutamate synthase
H8Z73_RS00180	COG0067	glutamate synthase
H8Z73_RS00180	COG0069	glutamate synthase activity
H8Z73_RS00180	COG0070	glutamate synthase
H8Z73_RS00230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8Z73_RS00245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H8Z73_RS00250	COG0438	transferase activity, transferring glycosyl groups
H8Z73_RS00250	COG0297	glycogen (starch) synthase activity
H8Z73_RS00270	COG0367	asparagine synthase
H8Z73_RS00300	COG1132	(ABC) transporter
H8Z73_RS00330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z73_RS00415	COG1205	dead DEAH box helicase
H8Z73_RS00415	COG1111	helicase
H8Z73_RS00420	COG1272	protein, Hemolysin III
H8Z73_RS00440	COG0300	oxidoreductase activity
H8Z73_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS00465	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8Z73_RS00520	COG3237	CsbD-like
H8Z73_RS00565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z73_RS00570	COG0477	Major facilitator Superfamily
H8Z73_RS00610	COG0714	Associated with various cellular activities
H8Z73_RS00640	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H8Z73_RS00650	COG4772	TonB-dependent receptor
H8Z73_RS00660	COG0662	Cupin 2, conserved barrel domain protein
H8Z73_RS00665	COG1012	belongs to the aldehyde dehydrogenase family
H8Z73_RS00690	COG1304	FMN binding
H8Z73_RS00700	COG4585	Histidine kinase
H8Z73_RS00705	COG2197	response regulator
H8Z73_RS00725	COG3710	Transcriptional regulator
H8Z73_RS00730	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8Z73_RS00800	COG0366	Alpha amylase catalytic
H8Z73_RS00805	COG0366	Alpha amylase catalytic
H8Z73_RS00810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z73_RS00830	COG0657	acetylesterase activity
H8Z73_RS00830	COG2755	lipolytic protein G-D-S-L family
H8Z73_RS00840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H8Z73_RS00855	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z73_RS00860	COG1609	Transcriptional regulator
H8Z73_RS00865	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H8Z73_RS00870	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS00880	COG2755	lipolytic protein G-D-S-L family
H8Z73_RS00895	COG3186	Phenylalanine-4-hydroxylase
H8Z73_RS00900	COG1522	sequence-specific DNA binding
H8Z73_RS00910	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8Z73_RS00920	COG1119	ATPase activity
H8Z73_RS00935	COG1125	glycine betaine transport
H8Z73_RS00950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z73_RS00970	COG1396	sequence-specific DNA binding
H8Z73_RS00990	COG0489	protein tyrosine kinase activity
H8Z73_RS00995	COG2062	phosphohistidine phosphatase, SixA
H8Z73_RS01005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z73_RS01050	COG1968	undecaprenyl-diphosphatase activity
H8Z73_RS01055	COG0174	glutamine synthetase
H8Z73_RS01060	COG0347	Belongs to the P(II) protein family
H8Z73_RS01065	COG0004	ammonium transporteR
H8Z73_RS01070	COG3852	Histidine kinase
H8Z73_RS01075	COG2204	response regulator
H8Z73_RS01080	COG2032	superoxide dismutase activity
H8Z73_RS01085	COG2032	superoxide dismutase activity
H8Z73_RS01095	COG0346	lactoylglutathione lyase activity
H8Z73_RS01105	COG0183	Belongs to the thiolase family
H8Z73_RS01140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8Z73_RS01145	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H8Z73_RS01150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8Z73_RS01165	COG0028	Belongs to the TPP enzyme family
H8Z73_RS01170	COG2205	protein histidine kinase activity
H8Z73_RS01195	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8Z73_RS01210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z73_RS01220	COG0596	Alpha beta hydrolase
H8Z73_RS01225	COG0727	PFAM Uncharacterised protein family (UPF0153)
H8Z73_RS01230	COG0318	PFAM AMP-dependent synthetase and ligase
H8Z73_RS01235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z73_RS01245	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z73_RS01255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z73_RS01290	COG0339	signal peptide processing
H8Z73_RS01320	COG0475	glutathione-regulated potassium exporter activity
H8Z73_RS01325	COG0583	DNA-binding transcription factor activity
H8Z73_RS01330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H8Z73_RS01335	COG2224	Isocitrate lyase
H8Z73_RS01370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H8Z73_RS01375	COG1960	acyl-CoA dehydrogenase activity
H8Z73_RS01430	COG0523	cobalamin synthesis protein
H8Z73_RS01440	COG0697	spore germination
H8Z73_RS01450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H8Z73_RS01455	COG1846	Transcriptional regulator
H8Z73_RS01460	COG1764	response to oxidative stress
H8Z73_RS01485	COG2130	NADP-dependent
H8Z73_RS01500	COG1187	pseudouridine synthase activity
H8Z73_RS01515	COG1643	Atp-dependent helicase
H8Z73_RS01520	COG4807	Protein conserved in bacteria
H8Z73_RS01525	COG2351	hydroxyisourate hydrolase activity
H8Z73_RS01530	COG2072	flavoprotein involved in K transport
H8Z73_RS01550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8Z73_RS01585	COG1957	nucleoside hydrolase
H8Z73_RS01595	COG2252	PERMEase
H8Z73_RS01615	COG0084	hydrolase, TatD family'
H8Z73_RS01630	COG0583	DNA-binding transcription factor activity
H8Z73_RS01635	COG2814	Major facilitator Superfamily
H8Z73_RS01650	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8Z73_RS01655	COG1902	pentaerythritol trinitrate reductase activity
H8Z73_RS01675	COG0745	RESPONSE REGULATOR receiver
H8Z73_RS01680	COG2205	protein histidine kinase activity
H8Z73_RS01685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_RS01705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z73_RS01710	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z73_RS01715	COG0583	DNA-binding transcription factor activity
H8Z73_RS01745	COG0702	epimerase
H8Z73_RS01750	COG1733	regulation of RNA biosynthetic process
H8Z73_RS01780	COG0129	dihydroxy-acid dehydratase activity
H8Z73_RS01795	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8Z73_RS01850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8Z73_RS01855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8Z73_RS01880	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8Z73_RS01885	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H8Z73_RS01895	COG3485	protocatechuate 3,4-dioxygenase
H8Z73_RS01900	COG3485	protocatechuate 3,4-dioxygenase
H8Z73_RS01910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z73_RS01915	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8Z73_RS01925	COG1414	Transcriptional regulator
H8Z73_RS01935	COG0657	acetylesterase activity
H8Z73_RS01945	COG0445	tRNA wobble uridine modification
H8Z73_RS01955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8Z73_RS01985	COG2267	carboxylic ester hydrolase activity
H8Z73_RS01995	COG0156	8-amino-7-oxononanoate synthase activity
H8Z73_RS02000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8Z73_RS02005	COG1040	competence protein
H8Z73_RS02010	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z73_RS02090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z73_RS02160	COG3264	Mechanosensitive ion channel
H8Z73_RS02160	COG1511	domain protein
H8Z73_RS02165	COG1368	sulfuric ester hydrolase activity
H8Z73_RS02170	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z73_RS02175	COG2354	Protein conserved in bacteria
H8Z73_RS02185	COG0297	glycogen (starch) synthase activity
H8Z73_RS02190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z73_RS02195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z73_RS02220	COG0702	epimerase
H8Z73_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS02255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z73_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS02270	COG0513	Belongs to the DEAD box helicase family
H8Z73_RS02290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8Z73_RS02300	COG3483	tryptophan 2,3-dioxygenase activity
H8Z73_RS02305	COG3104	oligopeptide transport
H8Z73_RS02330	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H8Z73_RS02345	COG1320	monovalent cation:proton antiporter activity
H8Z73_RS02350	COG2212	antiporter activity
H8Z73_RS02360	COG0651	ATP synthesis coupled electron transport
H8Z73_RS02365	COG1006	Multisubunit Na H antiporter MnhC subunit
H8Z73_RS02370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z73_RS02370	COG2111	Na H antiporter
H8Z73_RS02390	COG3179	chitinase
H8Z73_RS02410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8Z73_RS02415	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H8Z73_RS02430	COG0456	acetyltransferase
H8Z73_RS02435	COG1597	lipid kinase activity
H8Z73_RS02460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8Z73_RS02465	COG0134	indole-3-glycerol-phosphate synthase activity
H8Z73_RS02475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z73_RS02480	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8Z73_RS02490	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H8Z73_RS02500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8Z73_RS02515	COG1051	belongs to the nudix hydrolase family
H8Z73_RS02555	COG0316	Belongs to the HesB IscA family
H8Z73_RS02570	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z73_RS02585	COG2814	Major facilitator Superfamily
H8Z73_RS02590	COG0583	DNA-binding transcription factor activity
H8Z73_RS02595	COG2814	Major facilitator Superfamily
H8Z73_RS02600	COG1289	transmembrane transporter activity
H8Z73_RS02610	COG0151	Belongs to the GarS family
H8Z73_RS02620	COG0138	bifunctional purine biosynthesis protein purh
H8Z73_RS02625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z73_RS02630	COG2267	carboxylic ester hydrolase activity
H8Z73_RS02635	COG2453	phosphatase
H8Z73_RS02635	COG0671	phosphoesterase, PA-phosphatase related
H8Z73_RS02660	COG4589	Belongs to the CDS family
H8Z73_RS02665	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H8Z73_RS02700	COG0439	Biotin carboxylase
H8Z73_RS02710	COG0511	ligase activity, forming carbon-carbon bonds
H8Z73_RS02715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8Z73_RS02725	COG1324	tolerance protein
H8Z73_RS02750	COG0300	oxidoreductase activity
H8Z73_RS02755	COG2356	endonuclease I
H8Z73_RS02770	COG0459	protein refolding
H8Z73_RS02785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8Z73_RS02800	COG3386	PFAM SMP-30 Gluconolaconase
H8Z73_RS02810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H8Z73_RS02815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z73_RS02830	COG0778	Nitroreductase
H8Z73_RS02835	COG2353	YceI-like domain
H8Z73_RS02865	COG3052	prosthetic group binding
H8Z73_RS02890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8Z73_RS02900	COG1802	Transcriptional regulator
H8Z73_RS02955	COG4221	oxidoreductase activity
H8Z73_RS02970	COG4221	oxidoreductase activity
H8Z73_RS02980	COG0435	Glutathione S-transferase
H8Z73_RS03005	COG2409	Drug exporters of the RND superfamily
H8Z73_RS03010	COG0823	Involved in the tonB-independent uptake of proteins
H8Z73_RS03010	COG1506	peptidase
H8Z73_RS03050	COG0697	spore germination
H8Z73_RS03065	COG1113	amino acid transport
H8Z73_RS03085	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H8Z73_RS03120	COG5001	Diguanylate cyclase
H8Z73_RS03125	COG0840	transmembrane signaling receptor activity
H8Z73_RS03130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z73_RS03130	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z73_RS03135	COG0659	secondary active sulfate transmembrane transporter activity
H8Z73_RS03150	COG2943	transferase activity, transferring hexosyl groups
H8Z73_RS03160	COG3275	phosphorelay sensor kinase activity
H8Z73_RS03170	COG0181	hydroxymethylbilane synthase activity
H8Z73_RS03200	COG0436	Aminotransferase
H8Z73_RS03210	COG2832	Protein of unknown function (DUF454)
H8Z73_RS03220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8Z73_RS03230	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H8Z73_RS03235	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H8Z73_RS03240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H8Z73_RS03265	COG2226	methyltransferase
H8Z73_RS03270	COG5001	Diguanylate cyclase
H8Z73_RS03270	COG3300	MHYT domain
H8Z73_RS03275	COG0308	aminopeptidase N
H8Z73_RS03320	COG3284	Transcriptional regulator
H8Z73_RS03325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z73_RS03330	COG1077	Cell shape determining protein MreB Mrl
H8Z73_RS03335	COG1792	Involved in formation and maintenance of cell shape
H8Z73_RS03350	COG0772	Belongs to the SEDS family
H8Z73_RS03360	COG2951	lytic endotransglycosylase activity
H8Z73_RS03365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8Z73_RS03370	COG1686	Belongs to the peptidase S11 family
H8Z73_RS03380	COG2921	Belongs to the UPF0250 family
H8Z73_RS03385	COG0321	lipoyl(octanoyl) transferase activity
H8Z73_RS03390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8Z73_RS03405	COG0583	DNA-binding transcription factor activity
H8Z73_RS03415	COG1056	cytidyltransferase-related domain
H8Z73_RS03415	COG1051	belongs to the nudix hydrolase family
H8Z73_RS03450	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H8Z73_RS03455	COG0673	inositol 2-dehydrogenase activity
H8Z73_RS03460	COG2823	Periplasmic or secreted lipoprotein
H8Z73_RS03465	COG4251	negative regulation of phosphorylation
H8Z73_RS03470	COG0784	Response regulator, receiver
H8Z73_RS03475	COG4191	Histidine kinase
H8Z73_RS03480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8Z73_RS03535	COG1459	type II secretion system
H8Z73_RS03585	COG3250	beta-galactosidase activity
H8Z73_RS03600	COG2188	Transcriptional regulator
H8Z73_RS03610	COG1609	Transcriptional regulator
H8Z73_RS03615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z73_RS03620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8Z73_RS03630	COG0617	tRNA 3'-terminal CCA addition
H8Z73_RS03635	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H8Z73_RS03640	COG1012	belongs to the aldehyde dehydrogenase family
H8Z73_RS03645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8Z73_RS03660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z73_RS03675	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H8Z73_RS03680	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z73_RS03695	COG2205	protein histidine kinase activity
H8Z73_RS03725	COG3791	Glutathione-dependent formaldehyde-activating
H8Z73_RS03735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z73_RS03745	COG0697	spore germination
H8Z73_RS03755	COG0488	(ABC) transporter
H8Z73_RS03765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8Z73_RS03770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8Z73_RS03780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z73_RS03780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z73_RS03800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8Z73_RS03805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z73_RS03810	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8Z73_RS03830	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H8Z73_RS03835	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H8Z73_RS03840	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H8Z73_RS03845	COG2205	protein histidine kinase activity
H8Z73_RS03850	COG0745	RESPONSE REGULATOR receiver
H8Z73_RS03865	COG0277	FAD linked oxidase domain protein
H8Z73_RS03870	COG1988	membrane-bound metal-dependent
H8Z73_RS03875	COG0792	nuclease activity
H8Z73_RS03910	COG0275	rRNA processing
H8Z73_RS03915	COG3116	cell division
H8Z73_RS03925	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8Z73_RS03930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8Z73_RS03935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z73_RS03945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8Z73_RS03950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z73_RS03955	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z73_RS03960	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H8Z73_RS03975	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8Z73_RS03985	COG0739	heme binding
H8Z73_RS03990	COG0653	protein targeting
H8Z73_RS03995	COG0494	nUDIX hydrolase
H8Z73_RS04005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z73_RS04015	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS04015	COG0604	alcohol dehydrogenase
H8Z73_RS04015	COG3321	synthase
H8Z73_RS04030	COG0366	Alpha amylase catalytic
H8Z73_RS04055	COG2226	methyltransferase
H8Z73_RS04060	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H8Z73_RS04070	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8Z73_RS04110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8Z73_RS04120	COG4106	trans-aconitate 2-methyltransferase activity
H8Z73_RS04125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z73_RS04135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z73_RS04140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8Z73_RS04145	COG0667	Aldo Keto reductase
H8Z73_RS04155	COG4771	TonB-dependent receptor
H8Z73_RS04175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z73_RS04180	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H8Z73_RS04190	COG2175	clavaminate synthase activity
H8Z73_RS04200	COG4181	ATPase activity
H8Z73_RS04225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8Z73_RS04245	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8Z73_RS04250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H8Z73_RS04265	COG3829	transcription factor binding
H8Z73_RS04275	COG1116	anion transmembrane transporter activity
H8Z73_RS04280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z73_RS04290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z73_RS04295	COG0431	NADPH-dependent FMN reductase
H8Z73_RS04320	COG0747	negative chemotaxis
H8Z73_RS04330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8Z73_RS04340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8Z73_RS04345	COG2967	ApaG domain
H8Z73_RS04350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8Z73_RS04355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8Z73_RS04360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z73_RS04365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H8Z73_RS04380	COG0123	including yeast histone deacetylase and acetoin utilization protein
H8Z73_RS04385	COG2096	Adenosyltransferase
H8Z73_RS04400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z73_RS04405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z73_RS04435	COG3384	dioxygenase
H8Z73_RS04440	COG0583	DNA-binding transcription factor activity
H8Z73_RS04455	COG1024	Enoyl-CoA hydratase
H8Z73_RS04475	COG3386	PFAM SMP-30 Gluconolaconase
H8Z73_RS04490	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H8Z73_RS04515	COG0697	spore germination
H8Z73_RS04520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z73_RS04540	COG5002	protein histidine kinase activity
H8Z73_RS04540	COG2205	protein histidine kinase activity
H8Z73_RS04540	COG0784	Response regulator, receiver
H8Z73_RS04545	COG2197	response regulator
H8Z73_RS04555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8Z73_RS04565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8Z73_RS04570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z73_RS04575	COG0583	DNA-binding transcription factor activity
H8Z73_RS04580	COG3634	alkyl hydroperoxide reductase activity
H8Z73_RS04590	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z73_RS04610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z73_RS04610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z73_RS04640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8Z73_RS04665	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H8Z73_RS04680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z73_RS04685	COG1404	Belongs to the peptidase S8 family
H8Z73_RS04690	COG1404	Belongs to the peptidase S8 family
H8Z73_RS04695	COG1404	Belongs to the peptidase S8 family
H8Z73_RS04700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8Z73_RS04725	COG1295	ribonuclease BN
H8Z73_RS04730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z73_RS04735	COG1254	Belongs to the acylphosphatase family
H8Z73_RS04750	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8Z73_RS04760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8Z73_RS04765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8Z73_RS04775	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H8Z73_RS04780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8Z73_RS04790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8Z73_RS04795	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H8Z73_RS04800	COG0193	aminoacyl-tRNA hydrolase activity
H8Z73_RS04805	COG0012	GTP binding
H8Z73_RS04825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z73_RS04840	COG0250	Participates in transcription elongation, termination and antitermination
H8Z73_RS04845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8Z73_RS04850	COG0081	regulation of translation
H8Z73_RS04855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8Z73_RS04860	COG0222	ribosome binding
H8Z73_RS04865	COG0085	RNA polymerase activity
H8Z73_RS04870	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8Z73_RS04875	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8Z73_RS04880	COG0049	tRNA binding
H8Z73_RS04885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8Z73_RS04890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z73_RS04895	COG0051	transcription antitermination factor activity, RNA binding
H8Z73_RS04900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8Z73_RS04905	COG0088	Forms part of the polypeptide exit tunnel
H8Z73_RS04910	COG0089	rRNA binding
H8Z73_RS04915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8Z73_RS04920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8Z73_RS04930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8Z73_RS04935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8Z73_RS04940	COG0255	Belongs to the universal ribosomal protein uL29 family
H8Z73_RS04945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8Z73_RS04955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8Z73_RS04960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8Z73_RS04970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8Z73_RS04975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8Z73_RS04980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8Z73_RS04990	COG1841	ribosomal large subunit assembly
H8Z73_RS04995	COG0200	Binds to the 23S rRNA
H8Z73_RS05000	COG0201	protein transport
H8Z73_RS05025	COG0203	ribosomal protein L17
H8Z73_RS05030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H8Z73_RS05045	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H8Z73_RS05055	COG0154	amidase activity
H8Z73_RS05065	COG1217	gtp-binding protein TYPA
H8Z73_RS05070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8Z73_RS05075	COG0039	L-malate dehydrogenase activity
H8Z73_RS05080	COG0625	glutathione transferase activity
H8Z73_RS05090	COG0446	pyridine nucleotide-disulphide oxidoreductase
H8Z73_RS05090	COG1902	pentaerythritol trinitrate reductase activity
H8Z73_RS05095	COG0604	alcohol dehydrogenase
H8Z73_RS05120	COG0156	8-amino-7-oxononanoate synthase activity
H8Z73_RS05125	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H8Z73_RS05130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H8Z73_RS05135	COG4208	sulfate ABC transporter
H8Z73_RS05140	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H8Z73_RS05150	COG1063	alcohol dehydrogenase
H8Z73_RS05180	COG0406	alpha-ribazole phosphatase activity
H8Z73_RS05185	COG0285	dihydrofolate synthase activity
H8Z73_RS05205	COG2833	Protein of unknown function (DUF455)
H8Z73_RS05215	COG3291	Pkd domain containing protein
H8Z73_RS05225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z73_RS05230	COG0671	phosphoesterase, PA-phosphatase related
H8Z73_RS05235	COG0438	transferase activity, transferring glycosyl groups
H8Z73_RS05245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8Z73_RS05260	COG4783	chaperone-mediated protein folding
H8Z73_RS05275	COG0473	3-isopropylmalate dehydrogenase activity
H8Z73_RS05365	COG2801	Transposase and inactivated derivatives
H8Z73_RS05390	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8Z73_RS05400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8Z73_RS05430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z73_RS05440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z73_RS05450	COG0328	RNA-DNA hybrid ribonuclease activity
H8Z73_RS05455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z73_RS05460	COG0631	protein serine/threonine phosphatase activity
H8Z73_RS05475	COG0859	PFAM glycosyl transferase family 9
H8Z73_RS05480	COG3642	lipopolysaccharide core region biosynthetic process
H8Z73_RS05485	COG1234	tRNA 3'-trailer cleavage
H8Z73_RS05490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8Z73_RS05500	COG0315	cyclic pyranopterin monophosphate synthase activity
H8Z73_RS05505	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8Z73_RS05510	COG0314	molybdopterin synthase activity
H8Z73_RS05590	COG2003	Belongs to the UPF0758 family
H8Z73_RS05610	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H8Z73_RS05680	COG0210	DNA helicase
H8Z73_RS05725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8Z73_RS05730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8Z73_RS05735	COG0537	adenosine 5'-monophosphoramidase activity
H8Z73_RS05755	COG0714	Associated with various cellular activities
H8Z73_RS05775	COG0424	maF-like protein
H8Z73_RS05780	COG1399	metal-binding, possibly nucleic acid-binding protein
H8Z73_RS05785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8Z73_RS05790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z73_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS05820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8Z73_RS05825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8Z73_RS05850	COG3829	transcription factor binding
H8Z73_RS05870	COG3609	addiction module antidote protein, CC2985 family
H8Z73_RS05900	COG2373	Large extracellular alpha-helical protein
H8Z73_RS05915	COG4953	penicillin-binding protein 1C
H8Z73_RS05935	COG0678	peroxiredoxin activity
H8Z73_RS05955	COG0330	HflC and HflK could
H8Z73_RS05960	COG0330	HflC and HflK could
H8Z73_RS05970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8Z73_RS05975	COG0308	aminopeptidase N
H8Z73_RS05980	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS05985	COG1309	transcriptional regulator
H8Z73_RS06030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H8Z73_RS06060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z73_RS06070	COG3387	PFAM Glycoside hydrolase 15-related
H8Z73_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS06080	COG3537	Alpha-1,2-mannosidase
H8Z73_RS06100	COG0492	ferredoxin-NADP+ reductase activity
H8Z73_RS06125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z73_RS06130	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z73_RS06135	COG2080	2 iron, 2 sulfur cluster binding
H8Z73_RS06170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z73_RS06185	COG0587	DNA-directed DNA polymerase activity
H8Z73_RS06205	COG1297	OPT oligopeptide transporter protein
H8Z73_RS06220	COG0823	Involved in the tonB-independent uptake of proteins
H8Z73_RS06220	COG1506	peptidase
H8Z73_RS06235	COG2207	Transcriptional regulator
H8Z73_RS06235	COG1917	Cupin 2, conserved barrel domain protein
H8Z73_RS06250	COG0753	catalase activity
H8Z73_RS06255	COG0656	L-ascorbic acid biosynthetic process
H8Z73_RS06265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z73_RS06265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z73_RS06270	COG2814	Major facilitator Superfamily
H8Z73_RS06285	COG2194	sulfuric ester hydrolase activity
H8Z73_RS06300	COG0745	RESPONSE REGULATOR receiver
H8Z73_RS06305	COG0642	Histidine kinase
H8Z73_RS06315	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8Z73_RS06320	COG2894	cell division
H8Z73_RS06325	COG0850	regulation of cytokinetic process
H8Z73_RS06335	COG4585	Histidine kinase
H8Z73_RS06340	COG2197	response regulator
H8Z73_RS06355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8Z73_RS06380	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8Z73_RS06390	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H8Z73_RS06410	COG1946	Acyl-CoA thioesterase
H8Z73_RS06425	COG0824	Thioesterase
H8Z73_RS06430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8Z73_RS06435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8Z73_RS06440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8Z73_RS06445	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8Z73_RS06450	COG0268	Binds directly to 16S ribosomal RNA
H8Z73_RS06460	COG0196	riboflavin kinase activity
H8Z73_RS06465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8Z73_RS06470	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8Z73_RS06475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8Z73_RS06490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8Z73_RS06495	COG1845	cytochrome c oxidase, subunit III
H8Z73_RS06500	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8Z73_RS06515	COG3152	Membrane
H8Z73_RS06525	COG2207	Transcriptional regulator
H8Z73_RS06540	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z73_RS06545	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z73_RS06550	COG2172	sigma factor antagonist activity
H8Z73_RS06575	COG4771	TonB-dependent receptor
H8Z73_RS06585	COG5507	3-demethylubiquinone-9 3-methyltransferase
H8Z73_RS06590	COG2205	protein histidine kinase activity
H8Z73_RS06600	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z73_RS06605	COG4999	Histidine kinase
H8Z73_RS06605	COG3850	Histidine kinase
H8Z73_RS06605	COG3437	response regulator, receiver
H8Z73_RS06605	COG2205	protein histidine kinase activity
H8Z73_RS06610	COG4191	Histidine kinase
H8Z73_RS06610	COG0784	Response regulator, receiver
H8Z73_RS06640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z73_RS06645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8Z73_RS06655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z73_RS06660	COG0228	four-way junction DNA binding
H8Z73_RS06665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8Z73_RS06670	COG0336	Belongs to the RNA methyltransferase TrmD family
H8Z73_RS06675	COG0335	large ribosomal subunit rRNA binding
H8Z73_RS06680	COG0534	Mate efflux family protein
H8Z73_RS06700	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H8Z73_RS06710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8Z73_RS06720	COG3209	COG3209 Rhs family protein
H8Z73_RS06740	COG3250	beta-galactosidase activity
H8Z73_RS06745	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H8Z73_RS06765	COG1960	acyl-CoA dehydrogenase activity
H8Z73_RS06770	COG1024	Enoyl-CoA hydratase
H8Z73_RS06790	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z73_RS06790	COG1024	Enoyl-CoA hydratase
H8Z73_RS06805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z73_RS06810	COG0481	GTPase activity
H8Z73_RS06825	COG0571	ribonuclease III activity
H8Z73_RS06830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8Z73_RS06835	COG1381	Involved in DNA repair and RecF pathway recombination
H8Z73_RS06845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z73_RS06850	COG2954	triphosphatase activity
H8Z73_RS06855	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H8Z73_RS06860	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H8Z73_RS06865	COG3046	protein related to deoxyribodipyrimidine photolyase
H8Z73_RS06870	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z73_RS06875	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H8Z73_RS06880	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8Z73_RS06885	COG1278	Cold shock
H8Z73_RS06890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z73_RS06900	COG1201	RNA secondary structure unwinding
H8Z73_RS06905	COG1793	dna ligase
H8Z73_RS06915	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z73_RS06915	COG1793	dna ligase
H8Z73_RS06945	COG0183	Belongs to the thiolase family
H8Z73_RS06970	COG1451	nucleotide metabolic process
H8Z73_RS06975	COG5487	UPF0391 membrane protein
H8Z73_RS06985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8Z73_RS07000	COG1077	Cell shape determining protein MreB Mrl
H8Z73_RS07005	COG1047	Peptidyl-prolyl cis-trans
H8Z73_RS07010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H8Z73_RS07015	COG2824	Alkylphosphonate utilization operon protein PhnA
H8Z73_RS07020	COG1902	pentaerythritol trinitrate reductase activity
H8Z73_RS07025	COG2814	Major facilitator Superfamily
H8Z73_RS07060	COG0392	lysyltransferase activity
H8Z73_RS07060	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H8Z73_RS07070	COG0251	oxidation-reduction process
H8Z73_RS07075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z73_RS07090	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z73_RS07115	COG1595	DNA-templated transcription, initiation
H8Z73_RS07130	COG2878	Part of a membrane complex involved in electron transport
H8Z73_RS07140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z73_RS07140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z73_RS07155	COG1131	(ABC) transporter
H8Z73_RS07160	COG0346	lactoylglutathione lyase activity
H8Z73_RS07165	COG0833	amino acid
H8Z73_RS07170	COG2040	homocysteine
H8Z73_RS07180	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z73_RS07200	COG1695	Transcriptional regulator
H8Z73_RS07220	COG1981	membrane
H8Z73_RS07235	COG0825	malonyl-CoA metabolic process
H8Z73_RS07245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8Z73_RS07250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z73_RS07255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z73_RS07260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z73_RS07265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z73_RS07280	COG0750	zinc metalloprotease
H8Z73_RS07285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8Z73_RS07290	COG0575	Belongs to the CDS family
H8Z73_RS07295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8Z73_RS07300	COG0233	cytoplasmic translational termination
H8Z73_RS07305	COG0528	UMP kinase activity
H8Z73_RS07315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8Z73_RS07320	COG0052	Belongs to the universal ribosomal protein uS2 family
H8Z73_RS07360	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H8Z73_RS07370	COG1393	Belongs to the ArsC family
H8Z73_RS07375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z73_RS07380	COG0367	asparagine synthase
H8Z73_RS07390	COG4774	siderophore transport
H8Z73_RS07405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z73_RS07435	COG1566	PFAM secretion protein HlyD family protein
H8Z73_RS07440	COG2814	Major facilitator Superfamily
H8Z73_RS07490	COG0339	signal peptide processing
H8Z73_RS07495	COG0386	Belongs to the glutathione peroxidase family
H8Z73_RS07550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8Z73_RS07555	COG0084	hydrolase, TatD family'
H8Z73_RS07570	COG1960	acyl-CoA dehydrogenase activity
H8Z73_RS07585	COG0367	asparagine synthase
H8Z73_RS07595	COG0305	Participates in initiation and elongation during chromosome replication
H8Z73_RS07600	COG0415	Belongs to the DNA photolyase family
H8Z73_RS07610	COG0583	DNA-binding transcription factor activity
H8Z73_RS07625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_RS07655	COG3706	GGDEF domain
H8Z73_RS07680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8Z73_RS07695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z73_RS07705	COG0497	DNA recombination
H8Z73_RS07710	COG1420	regulation of RNA biosynthetic process
H8Z73_RS07715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8Z73_RS07720	COG0443	Heat shock 70 kDa protein
H8Z73_RS07725	COG0484	heat shock protein binding
H8Z73_RS07735	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H8Z73_RS07765	COG0583	DNA-binding transcription factor activity
H8Z73_RS07770	COG1132	(ABC) transporter
H8Z73_RS07805	COG2850	peptidyl-arginine hydroxylation
H8Z73_RS07825	COG1253	flavin adenine dinucleotide binding
H8Z73_RS07855	COG1131	(ABC) transporter
H8Z73_RS07860	COG1725	Transcriptional regulator
H8Z73_RS07870	COG0386	Belongs to the glutathione peroxidase family
H8Z73_RS07885	COG2900	Belongs to the SlyX family
H8Z73_RS07910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z73_RS07920	COG1410	methionine synthase
H8Z73_RS07920	COG0646	methionine synthase
H8Z73_RS07925	COG0646	methionine synthase
H8Z73_RS07925	COG1410	methionine synthase
H8Z73_RS07930	COG2226	methyltransferase
H8Z73_RS07935	COG1960	acyl-CoA dehydrogenase activity
H8Z73_RS07940	COG1960	acyl-CoA dehydrogenase activity
H8Z73_RS07945	COG1960	acyl-CoA dehydrogenase activity
H8Z73_RS07950	COG1960	acyl-CoA dehydrogenase activity
H8Z73_RS07965	COG0557	exoribonuclease II activity
H8Z73_RS07975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z73_RS07985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z73_RS07995	COG0704	Plays a role in the regulation of phosphate uptake
H8Z73_RS08000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8Z73_RS08005	COG0581	inorganic phosphate transmembrane transporter activity
H8Z73_RS08010	COG0573	inorganic phosphate transmembrane transporter activity
H8Z73_RS08015	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8Z73_RS08040	COG0659	secondary active sulfate transmembrane transporter activity
H8Z73_RS08045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8Z73_RS08055	COG1024	Enoyl-CoA hydratase
H8Z73_RS08065	COG0494	nUDIX hydrolase
H8Z73_RS08100	COG0488	(ABC) transporter
H8Z73_RS08110	COG0116	Belongs to the methyltransferase superfamily
H8Z73_RS08110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z73_RS08115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8Z73_RS08140	COG2925	Exonuclease
H8Z73_RS08150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z73_RS08155	COG3844	kynureninase activity
H8Z73_RS08165	COG0662	Cupin 2, conserved barrel domain protein
H8Z73_RS08170	COG0288	reversible hydration of carbon dioxide
H8Z73_RS08220	COG3002	Belongs to the UPF0753 family
H8Z73_RS08245	COG2808	Putative FMN-binding domain
H8Z73_RS08265	COG0017	Asparaginyl-tRNA synthetase
H8Z73_RS08270	COG0316	Belongs to the HesB IscA family
H8Z73_RS08275	COG0360	Binds together with S18 to 16S ribosomal RNA
H8Z73_RS08280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8Z73_RS08285	COG0359	binds to the 23S rRNA
H8Z73_RS08295	COG3115	cell septum assembly
H8Z73_RS08305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z73_RS08310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8Z73_RS08315	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H8Z73_RS08330	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8Z73_RS08340	COG4993	Dehydrogenase
H8Z73_RS08350	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H8Z73_RS08360	COG2986	histidine ammonia-lyase
H8Z73_RS08365	COG1228	amidohydrolase
H8Z73_RS08410	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H8Z73_RS08415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8Z73_RS08420	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H8Z73_RS08425	COG0077	Prephenate dehydratase
H8Z73_RS08425	COG1605	Chorismate mutase
H8Z73_RS08430	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8Z73_RS08445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8Z73_RS08450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z73_RS08455	COG0583	DNA-binding transcription factor activity
H8Z73_RS08520	COG0840	transmembrane signaling receptor activity
H8Z73_RS08545	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8Z73_RS08550	COG0784	Response regulator, receiver
H8Z73_RS08550	COG4191	Histidine kinase
H8Z73_RS08565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z73_RS08575	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z73_RS08585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z73_RS08600	COG1595	DNA-templated transcription, initiation
H8Z73_RS08650	COG2244	polysaccharide biosynthetic process
H8Z73_RS08680	COG2264	protein methyltransferase activity
H8Z73_RS08690	COG0438	transferase activity, transferring glycosyl groups
H8Z73_RS08705	COG1136	(ABC) transporter
H8Z73_RS08715	COG0477	Major facilitator Superfamily
H8Z73_RS08720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z73_RS08735	COG1253	flavin adenine dinucleotide binding
H8Z73_RS08745	COG0306	phosphate transporter
H8Z73_RS08770	COG0504	CTP synthase activity
H8Z73_RS08775	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8Z73_RS08785	COG0148	phosphopyruvate hydratase activity
H8Z73_RS08790	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H8Z73_RS08795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8Z73_RS08800	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8Z73_RS08805	COG0585	pseudouridine synthase activity
H8Z73_RS08810	COG2840	Smr protein MutS2
H8Z73_RS08815	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8Z73_RS08820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z73_RS08825	COG1238	metal cluster binding
H8Z73_RS08840	COG1534	Rna-binding protein
H8Z73_RS08845	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H8Z73_RS08855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8Z73_RS08860	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8Z73_RS08870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8Z73_RS08875	COG1546	Belongs to the CinA family
H8Z73_RS08885	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z73_RS08890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8Z73_RS08895	COG2137	regulation of response to DNA damage stimulus
H8Z73_RS08900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8Z73_RS08905	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8Z73_RS08920	COG1741	Belongs to the pirin family
H8Z73_RS08925	COG0583	DNA-binding transcription factor activity
H8Z73_RS08950	COG0352	thiamine-phosphate diphosphorylase activity
H8Z73_RS08950	COG0351	phosphomethylpyrimidine kinase
H8Z73_RS08965	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8Z73_RS08970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8Z73_RS08985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z73_RS08995	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8Z73_RS09000	COG3734	2-keto-3-deoxy-galactonokinase
H8Z73_RS09010	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z73_RS09015	COG0800	Aldolase
H8Z73_RS09050	COG1501	Belongs to the glycosyl hydrolase 31 family
H8Z73_RS09060	COG1070	Carbohydrate kinase
H8Z73_RS09065	COG2115	Belongs to the xylose isomerase family
H8Z73_RS09070	COG0477	Major facilitator Superfamily
H8Z73_RS09090	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z73_RS09095	COG1469	GTP cyclohydrolase I activity
H8Z73_RS09115	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8Z73_RS09120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8Z73_RS09125	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H8Z73_RS09130	COG0166	Belongs to the GPI family
H8Z73_RS09150	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z73_RS09160	COG3706	GGDEF domain
H8Z73_RS09160	COG2203	Gaf domain
H8Z73_RS09160	COG4251	negative regulation of phosphorylation
H8Z73_RS09160	COG5001	Diguanylate cyclase
H8Z73_RS09170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z73_RS09175	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H8Z73_RS09185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8Z73_RS09190	COG0671	phosphoesterase, PA-phosphatase related
H8Z73_RS09205	COG1794	racemase activity, acting on amino acids and derivatives
H8Z73_RS09210	COG0697	spore germination
H8Z73_RS09215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8Z73_RS09220	COG0167	dihydroorotate dehydrogenase activity
H8Z73_RS09235	COG1012	belongs to the aldehyde dehydrogenase family
H8Z73_RS09250	COG1215	transferase activity, transferring glycosyl groups
H8Z73_RS09255	COG1649	PFAM Uncharacterised BCR, COG1649
H8Z73_RS09255	COG0726	polysaccharide deacetylase
H8Z73_RS09270	COG3210	domain, Protein
H8Z73_RS09340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z73_RS09345	COG0124	histidyl-tRNA synthetase
H8Z73_RS09355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8Z73_RS09360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8Z73_RS09365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z73_RS09370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8Z73_RS09370	COG0131	Imidazoleglycerol-phosphate dehydratase
H8Z73_RS09375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8Z73_RS09380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8Z73_RS09385	COG0107	imidazoleglycerol-phosphate synthase activity
H8Z73_RS09390	COG0140	phosphoribosyl-ATP diphosphatase activity
H8Z73_RS09390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8Z73_RS09405	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8Z73_RS09410	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8Z73_RS09415	COG0235	Class ii aldolase
H8Z73_RS09420	COG0531	amino acid
H8Z73_RS09425	COG0531	amino acid
H8Z73_RS09435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8Z73_RS09440	COG0277	FAD linked oxidase domain protein
H8Z73_RS09460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z73_RS09505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z73_RS09510	COG2258	MOSC domain
H8Z73_RS09515	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8Z73_RS09520	COG0505	Belongs to the CarA family
H8Z73_RS09530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8Z73_RS09535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z73_RS09545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8Z73_RS09585	COG3279	Response regulator of the LytR AlgR family
H8Z73_RS09595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8Z73_RS09605	COG0784	Response regulator, receiver
H8Z73_RS09605	COG2198	Histidine kinase
H8Z73_RS09605	COG2205	protein histidine kinase activity
H8Z73_RS09610	COG1024	Enoyl-CoA hydratase
H8Z73_RS09645	COG2267	carboxylic ester hydrolase activity
H8Z73_RS09655	COG2201	protein-glutamate methylesterase activity
H8Z73_RS09660	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H8Z73_RS09670	COG0840	transmembrane signaling receptor activity
H8Z73_RS09680	COG0835	chemotaxis
H8Z73_RS09690	COG0840	transmembrane signaling receptor activity
H8Z73_RS09695	COG0840	transmembrane signaling receptor activity
H8Z73_RS09710	COG0840	transmembrane signaling receptor activity
H8Z73_RS09715	COG0840	transmembrane signaling receptor activity
H8Z73_RS09720	COG0840	transmembrane signaling receptor activity
H8Z73_RS09725	COG0840	transmembrane signaling receptor activity
H8Z73_RS09730	COG0840	transmembrane signaling receptor activity
H8Z73_RS09740	COG0840	transmembrane signaling receptor activity
H8Z73_RS09760	COG2198	Histidine kinase
H8Z73_RS09760	COG0643	Histidine kinase
H8Z73_RS09765	COG0745	RESPONSE REGULATOR receiver
H8Z73_RS09775	COG0835	chemotaxis
H8Z73_RS09785	COG1360	Flagellar Motor Protein
H8Z73_RS09790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8Z73_RS09830	COG0641	radical SAM
H8Z73_RS09840	COG2198	Histidine kinase
H8Z73_RS09840	COG0784	Response regulator, receiver
H8Z73_RS09840	COG0643	Histidine kinase
H8Z73_RS09870	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z73_RS09895	COG1684	flagellar biosynthetic protein fliR
H8Z73_RS09910	COG3190	flagellar
H8Z73_RS09960	COG1677	Flagellar hook-basal body complex protein FliE
H8Z73_RS09990	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS09995	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS10000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z73_RS10020	COG2201	protein-glutamate methylesterase activity
H8Z73_RS10050	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H8Z73_RS10060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z73_RS10065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z73_RS10075	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8Z73_RS10075	COG3951	Flagellar rod assembly protein muramidase FlgJ
H8Z73_RS10080	COG1706	bacterial-type flagellum-dependent cell motility
H8Z73_RS10085	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H8Z73_RS10100	COG4787	bacterial-type flagellum-dependent cell motility
H8Z73_RS10110	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H8Z73_RS10115	COG1558	bacterial-type flagellum-dependent cell motility
H8Z73_RS10125	COG0784	Response regulator, receiver
H8Z73_RS10125	COG0835	chemotaxis
H8Z73_RS10145	COG5002	protein histidine kinase activity
H8Z73_RS10175	COG2915	High frequency lysogenization protein hflD homolog
H8Z73_RS10180	COG0482	sulfurtransferase activity
H8Z73_RS10195	COG0542	response to heat
H8Z73_RS10205	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H8Z73_RS10215	COG0492	ferredoxin-NADP+ reductase activity
H8Z73_RS10220	COG1674	ftsk spoiiie
H8Z73_RS10230	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H8Z73_RS10240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H8Z73_RS10245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8Z73_RS10250	COG0183	Belongs to the thiolase family
H8Z73_RS10255	COG1024	Enoyl-CoA hydratase
H8Z73_RS10255	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z73_RS10270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8Z73_RS10280	COG1426	Protein conserved in bacteria
H8Z73_RS10290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z73_RS10295	COG1160	GTP binding
H8Z73_RS10300	COG0303	'Molybdopterin
H8Z73_RS10305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8Z73_RS10340	COG0708	Exodeoxyribonuclease III
H8Z73_RS10350	COG0303	'Molybdopterin
H8Z73_RS10355	COG0746	molybdenum cofactor guanylyltransferase activity
H8Z73_RS10370	COG1914	H( )-stimulated, divalent metal cation uptake system
H8Z73_RS10385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H8Z73_RS10390	COG0668	transmembrane transport
H8Z73_RS10400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H8Z73_RS10415	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS10420	COG1183	phosphatidylcholine synthase activity
H8Z73_RS10430	COG3243	poly(R)-hydroxyalkanoic acid synthase
H8Z73_RS10445	COG0723	plastoquinol--plastocyanin reductase activity
H8Z73_RS10445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z73_RS10455	COG2183	response to ionizing radiation
H8Z73_RS10465	COG2205	protein histidine kinase activity
H8Z73_RS10465	COG0784	Response regulator, receiver
H8Z73_RS10530	COG0800	Aldolase
H8Z73_RS10535	COG0129	dihydroxy-acid dehydratase activity
H8Z73_RS10540	COG0363	glucosamine-6-phosphate deaminase activity
H8Z73_RS10545	COG0837	glucose binding
H8Z73_RS10550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z73_RS10575	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H8Z73_RS10590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8Z73_RS10595	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H8Z73_RS10605	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z73_RS10610	COG1136	(ABC) transporter
H8Z73_RS10625	COG0811	peptide transport
H8Z73_RS10635	COG1132	(ABC) transporter
H8Z73_RS10640	COG1663	tetraacyldisaccharide 4'-kinase activity
H8Z73_RS10645	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H8Z73_RS10650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8Z73_RS10660	COG0322	excinuclease ABC activity
H8Z73_RS10665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z73_RS10675	COG0582	viral genome integration into host DNA
H8Z73_RS10680	COG2801	Transposase and inactivated derivatives
H8Z73_RS10780	COG2003	Belongs to the UPF0758 family
H8Z73_RS10955	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z73_RS10960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z73_RS10965	COG0629	single-stranded DNA binding
H8Z73_RS11095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z73_RS11100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z73_RS11115	COG0582	viral genome integration into host DNA
H8Z73_RS11125	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H8Z73_RS11145	COG1054	Belongs to the UPF0176 family
H8Z73_RS11155	COG1530	ribonuclease E activity
H8Z73_RS11165	COG3064	Membrane
H8Z73_RS11170	COG0428	transporter
H8Z73_RS11180	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8Z73_RS11185	COG0316	Belongs to the HesB IscA family
H8Z73_RS11185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8Z73_RS11230	COG1073	alpha beta
H8Z73_RS11230	COG2226	methyltransferase
H8Z73_RS11240	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS11270	COG1238	metal cluster binding
H8Z73_RS11305	COG3279	Response regulator of the LytR AlgR family
H8Z73_RS11345	COG4566	intracellular signal transduction
H8Z73_RS11355	COG5001	Diguanylate cyclase
H8Z73_RS11375	COG3685	Protein conserved in bacteria
H8Z73_RS11400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z73_RS11400	COG1648	precorrin-2 dehydrogenase activity
H8Z73_RS11415	COG2814	Major facilitator Superfamily
H8Z73_RS11430	COG1335	isochorismatase
H8Z73_RS11450	COG2197	response regulator
H8Z73_RS11470	COG0583	DNA-binding transcription factor activity
H8Z73_RS11475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z73_RS11480	COG3002	Belongs to the UPF0753 family
H8Z73_RS11485	COG2801	Transposase and inactivated derivatives
H8Z73_RS11490	COG1396	sequence-specific DNA binding
H8Z73_RS11495	COG5489	Protein of unknown function (DUF736)
H8Z73_RS11505	COG2003	Belongs to the UPF0758 family
H8Z73_RS11535	COG0582	viral genome integration into host DNA
H8Z73_RS11550	COG4774	siderophore transport
H8Z73_RS11580	COG2336	PFAM SpoVT AbrB
H8Z73_RS11605	COG4206	TonB-dependent receptor
H8Z73_RS11645	COG2274	protein secretion by the type I secretion system
H8Z73_RS11700	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z73_RS11840	COG2084	Dehydrogenase
H8Z73_RS11860	COG2003	Belongs to the UPF0758 family
H8Z73_RS11895	COG0582	viral genome integration into host DNA
H8Z73_RS11900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z73_RS11900	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z73_RS11910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8Z73_RS11920	COG0475	glutathione-regulated potassium exporter activity
H8Z73_RS11920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z73_RS11925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8Z73_RS11935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z73_RS11940	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H8Z73_RS11950	COG0776	regulation of translation
H8Z73_RS11955	COG0539	negative regulation of cytoplasmic translation
H8Z73_RS11960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8Z73_RS11975	COG2957	Belongs to the agmatine deiminase family
H8Z73_RS11980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z73_RS12005	COG0395	ABC-type sugar transport system, permease component
H8Z73_RS12010	COG1175	transmembrane transport
H8Z73_RS12040	COG2350	Protein conserved in bacteria
H8Z73_RS12045	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H8Z73_RS12050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H8Z73_RS12055	COG1187	pseudouridine synthase activity
H8Z73_RS12075	COG0436	Aminotransferase
H8Z73_RS12080	COG4133	protoheme IX ABC transporter activity
H8Z73_RS12100	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z73_RS12105	COG1138	Cytochrome C-type biogenesis protein
H8Z73_RS12125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z73_RS12130	COG1278	Cold shock
H8Z73_RS12135	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8Z73_RS12140	COG4988	ABC transporter
H8Z73_RS12160	COG1294	oxidase, subunit
H8Z73_RS12185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8Z73_RS12195	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8Z73_RS12205	COG0165	Argininosuccinate lyase
H8Z73_RS12210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8Z73_RS12220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8Z73_RS12225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z73_RS12235	COG0137	argininosuccinate synthase activity
H8Z73_RS12240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8Z73_RS12250	COG0215	cysteine-tRNA ligase activity
H8Z73_RS12255	COG2166	iron-sulfur cluster assembly
H8Z73_RS12270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8Z73_RS12275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8Z73_RS12305	COG4302	ethanolamine ammonia-lyase activity
H8Z73_RS12360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8Z73_RS12365	COG0402	S-adenosylhomocysteine deaminase activity
H8Z73_RS12375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z73_RS12380	COG1509	lysine 2,3-aminomutase activity
H8Z73_RS12385	COG5001	Diguanylate cyclase
H8Z73_RS12385	COG3300	MHYT domain
H8Z73_RS12400	COG0483	inositol monophosphate 1-phosphatase activity
H8Z73_RS12405	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8Z73_RS12420	COG0488	(ABC) transporter
H8Z73_RS12425	COG0513	Belongs to the DEAD box helicase family
H8Z73_RS12430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8Z73_RS12435	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H8Z73_RS12450	COG0625	glutathione transferase activity
H8Z73_RS12460	COG4681	YaeQ
H8Z73_RS12465	COG2081	HI0933 family
H8Z73_RS12475	COG0501	Belongs to the peptidase M48B family
H8Z73_RS12480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z73_RS12485	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS12510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H8Z73_RS12515	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z73_RS12520	COG0802	atpase or kinase
H8Z73_RS12525	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8Z73_RS12525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z73_RS12530	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z73_RS12535	COG1570	exodeoxyribonuclease VII activity
H8Z73_RS12545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z73_RS12735	COG0835	chemotaxis
H8Z73_RS12740	COG0840	transmembrane signaling receptor activity
H8Z73_RS12745	COG2094	Belongs to the DNA glycosylase MPG family
H8Z73_RS12750	COG1201	RNA secondary structure unwinding
H8Z73_RS12770	COG2969	positive regulation of protein catabolic process
H8Z73_RS12775	COG0625	glutathione transferase activity
H8Z73_RS12780	COG2857	Cytochrome c1
H8Z73_RS12785	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8Z73_RS12790	COG0723	plastoquinol--plastocyanin reductase activity
H8Z73_RS12795	COG0741	lytic transglycosylase activity
H8Z73_RS12810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z73_RS12815	COG1702	phosphate starvation-inducible protein PhoH
H8Z73_RS12825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8Z73_RS12835	COG4535	Mg2 and Co2 transporter CorC
H8Z73_RS12850	COG1012	belongs to the aldehyde dehydrogenase family
H8Z73_RS12855	COG1177	transmembrane transport
H8Z73_RS12860	COG1176	ABC-type spermidine putrescine transport system, permease component I
H8Z73_RS12865	COG3842	ATPase activity
H8Z73_RS12885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H8Z73_RS12900	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H8Z73_RS12905	COG0174	glutamine synthetase
H8Z73_RS12910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z73_RS12920	COG2703	oxygen carrier activity
H8Z73_RS12925	COG0477	Major facilitator Superfamily
H8Z73_RS12935	COG0243	molybdopterin cofactor binding
H8Z73_RS12940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H8Z73_RS12945	COG2223	nitrite transmembrane transporter activity
H8Z73_RS12950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8Z73_RS12960	COG2733	membrane
H8Z73_RS12965	COG0784	Response regulator, receiver
H8Z73_RS12965	COG5002	protein histidine kinase activity
H8Z73_RS12965	COG2205	protein histidine kinase activity
H8Z73_RS12975	COG0477	Major facilitator Superfamily
H8Z73_RS12985	COG2902	Dehydrogenase
H8Z73_RS12995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_RS13000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z73_RS13005	COG1609	Transcriptional regulator
H8Z73_RS13010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z73_RS13010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z73_RS13015	COG1105	Belongs to the carbohydrate kinase PfkB family
H8Z73_RS13020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z73_RS13020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z73_RS13065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8Z73_RS13075	COG1862	Preprotein translocase
H8Z73_RS13080	COG0343	queuine tRNA-ribosyltransferase activity
H8Z73_RS13085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8Z73_RS13120	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8Z73_RS13125	COG3291	Pkd domain containing protein
H8Z73_RS13130	COG0405	Gamma-glutamyltransferase
H8Z73_RS13135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8Z73_RS13145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8Z73_RS13150	COG0742	ribosomal rna small subunit methyltransferase
H8Z73_RS13155	COG0326	Molecular chaperone. Has ATPase activity
H8Z73_RS13230	COG0531	amino acid
H8Z73_RS13245	COG0006	proline dipeptidase activity
H8Z73_RS13255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z73_RS13270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z73_RS13275	COG3938	Belongs to the proline racemase family
H8Z73_RS13285	COG0552	protein localization to endoplasmic reticulum
H8Z73_RS13290	COG1194	a g-specific adenine glycosylase
H8Z73_RS13295	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H8Z73_RS13300	COG0784	Response regulator, receiver
H8Z73_RS13300	COG4191	Histidine kinase
H8Z73_RS13315	COG0322	excinuclease ABC activity
H8Z73_RS13330	COG3040	lipid binding
H8Z73_RS13345	COG1960	acyl-CoA dehydrogenase activity
H8Z73_RS13355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8Z73_RS13375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z73_RS13380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z73_RS13385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z73_RS13410	COG0438	transferase activity, transferring glycosyl groups
H8Z73_RS13420	COG0438	transferase activity, transferring glycosyl groups
H8Z73_RS13425	COG0438	transferase activity, transferring glycosyl groups
H8Z73_RS13475	COG0072	phenylalanine-tRNA ligase activity
H8Z73_RS13475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z73_RS13480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8Z73_RS13495	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8Z73_RS13500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8Z73_RS13525	COG1082	Xylose isomerase domain protein TIM barrel
H8Z73_RS13615	COG3702	type iv secretory pathway
H8Z73_RS13635	COG2948	multi-organism process
H8Z73_RS13655	COG3505	Type IV secretory pathway VirD4
H8Z73_RS13670	COG0556	nucleotide-excision repair
H8Z73_RS13755	COG4695	Portal protein
H8Z73_RS13800	COG3179	chitinase
H8Z73_RS13855	COG3275	phosphorelay sensor kinase activity
H8Z73_RS13860	COG1611	Belongs to the LOG family
H8Z73_RS13870	COG2095	MarC family integral membrane protein
H8Z73_RS13880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z73_RS13915	COG1185	polyribonucleotide nucleotidyltransferase activity
H8Z73_RS13920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8Z73_RS13925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8Z73_RS13930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8Z73_RS13935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8Z73_RS13940	COG0195	Participates in both transcription termination and antitermination
H8Z73_RS13945	COG0779	Required for maturation of 30S ribosomal subunits
H8Z73_RS13955	COG1007	ATP synthesis coupled electron transport
H8Z73_RS13980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z73_RS13985	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8Z73_RS13995	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H8Z73_RS14000	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H8Z73_RS14005	COG0649	NAD binding
H8Z73_RS14010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z73_RS14015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z73_RS14020	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z73_RS14035	COG0149	triose-phosphate isomerase activity
H8Z73_RS14040	COG0300	oxidoreductase activity
H8Z73_RS14070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z73_RS14075	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8Z73_RS14080	COG0159	tryptophan synthase activity
H8Z73_RS14090	COG0133	tryptophan synthase activity
H8Z73_RS14100	COG0135	phosphoribosylanthranilate isomerase activity
H8Z73_RS14105	COG0101	tRNA pseudouridine synthase activity
H8Z73_RS14125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8Z73_RS14130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8Z73_RS14135	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8Z73_RS14140	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z73_RS14150	COG0688	phosphatidylethanolamine metabolic process
H8Z73_RS14160	COG0433	COG0433 Predicted ATPase
H8Z73_RS14165	COG0494	nUDIX hydrolase
H8Z73_RS14180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z73_RS14185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z73_RS14210	COG0717	Belongs to the dCTP deaminase family
H8Z73_RS14215	COG0489	protein tyrosine kinase activity
H8Z73_RS14235	COG3590	peptidase
H8Z73_RS14240	COG3590	peptidase
H8Z73_RS14260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z73_RS14265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z73_RS14270	COG2311	Membrane
H8Z73_RS14275	COG1047	Peptidyl-prolyl cis-trans
H8Z73_RS14280	COG0791	NLP P60 protein
H8Z73_RS14285	COG0791	NLP P60 protein
H8Z73_RS14295	COG4106	trans-aconitate 2-methyltransferase activity
H8Z73_RS14300	COG1301	dicarboxylic acid transport
H8Z73_RS14305	COG1785	Belongs to the alkaline phosphatase family
H8Z73_RS14310	COG0037	tRNA processing
H8Z73_RS14315	COG1722	exodeoxyribonuclease VII activity
H8Z73_RS14320	COG0142	geranyltranstransferase activity
H8Z73_RS14325	COG4104	PAAR repeat-containing protein
H8Z73_RS14335	COG0312	modulator of DNA gyrase
H8Z73_RS14340	COG3028	Belongs to the UPF0307 family
H8Z73_RS14345	COG0312	modulator of DNA gyrase
H8Z73_RS14355	COG3164	Protein of unknown function
H8Z73_RS14365	COG0424	maF-like protein
H8Z73_RS14370	COG2968	Membrane
H8Z73_RS14385	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8Z73_RS14400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8Z73_RS14415	COG0495	leucyl-tRNA aminoacylation
H8Z73_RS14425	COG3118	belongs to the thioredoxin family
H8Z73_RS14450	COG2155	Conserved Protein
H8Z73_RS14495	COG1132	(ABC) transporter
H8Z73_RS14525	COG1538	Outer membrane efflux protein
H8Z73_RS14530	COG0745	RESPONSE REGULATOR receiver
H8Z73_RS14535	COG5002	protein histidine kinase activity
H8Z73_RS14535	COG5000	phosphorelay sensor kinase activity
H8Z73_RS14540	COG0475	glutathione-regulated potassium exporter activity
H8Z73_RS14550	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z73_RS14570	COG1187	pseudouridine synthase activity
H8Z73_RS14575	COG5001	Diguanylate cyclase
H8Z73_RS14575	COG5002	protein histidine kinase activity
H8Z73_RS14625	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8Z73_RS14695	COG0667	Aldo Keto reductase
H8Z73_RS14700	COG2814	Major facilitator Superfamily
H8Z73_RS14705	COG0583	DNA-binding transcription factor activity
H8Z73_RS14715	COG2207	Transcriptional regulator
H8Z73_RS14725	COG1309	transcriptional regulator
H8Z73_RS14735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z73_RS14750	COG0735	belongs to the Fur family
H8Z73_RS14755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z73_RS14780	COG4452	Inner membrane protein CreD
H8Z73_RS14795	COG2205	protein histidine kinase activity
H8Z73_RS14800	COG0745	RESPONSE REGULATOR receiver
H8Z73_RS14805	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H8Z73_RS14815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8Z73_RS14845	COG0643	Histidine kinase
H8Z73_RS14845	COG2198	Histidine kinase
H8Z73_RS14850	COG0840	transmembrane signaling receptor activity
H8Z73_RS14855	COG0835	chemotaxis
H8Z73_RS14860	COG2199	diguanylate cyclase activity
H8Z73_RS14860	COG2200	EAL domain
H8Z73_RS14860	COG2202	Pas domain
H8Z73_RS14865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z73_RS14870	COG2201	protein-glutamate methylesterase activity
H8Z73_RS14875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z73_RS14880	COG3590	peptidase
H8Z73_RS14890	COG0588	phosphoglycerate mutase activity
H8Z73_RS14895	COG1515	deoxyribonuclease V activity
H8Z73_RS14905	COG1741	Belongs to the pirin family
H8Z73_RS14920	COG1741	Belongs to the pirin family
H8Z73_RS14925	COG1966	Carbon starvation protein
H8Z73_RS14930	COG2879	small protein
H8Z73_RS14965	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H8Z73_RS14970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z73_RS14975	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z73_RS14995	COG3706	GGDEF domain
H8Z73_RS14995	COG2203	Gaf domain
H8Z73_RS14995	COG5001	Diguanylate cyclase
H8Z73_RS14995	COG4251	negative regulation of phosphorylation
H8Z73_RS15000	COG0629	single-stranded DNA binding
H8Z73_RS15005	COG0142	geranyltranstransferase activity
H8Z73_RS15015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8Z73_RS15030	COG0527	aspartate kinase activity
H8Z73_RS15035	COG0384	phenazine biosynthesis protein PhzF
H8Z73_RS15040	COG0384	phenazine biosynthesis protein PhzF
H8Z73_RS15050	COG1764	response to oxidative stress
H8Z73_RS15055	COG0540	Belongs to the ATCase OTCase family
H8Z73_RS15060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8Z73_RS15065	COG1678	Uncharacterized ACR, COG1678
H8Z73_RS15070	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z73_RS15085	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z73_RS15100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8Z73_RS15115	COG0739	heme binding
H8Z73_RS15135	COG0693	protein deglycase activity
H8Z73_RS15145	COG1959	2 iron, 2 sulfur cluster binding
H8Z73_RS15150	COG0719	Fe-S assembly protein
H8Z73_RS15155	COG0396	ATPase activity
H8Z73_RS15160	COG0719	Fe-S assembly protein
H8Z73_RS15165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8Z73_RS15175	COG2146	nitrite reductase [NAD(P)H] activity
H8Z73_RS15180	COG4774	siderophore transport
H8Z73_RS15185	COG3128	pkhd-type hydroxylase
H8Z73_RS15210	COG1477	protein flavinylation
H8Z73_RS15215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z73_RS15230	COG1555	photosystem II stabilization
H8Z73_RS15235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z73_RS15245	COG3178	'Phosphotransferase
H8Z73_RS15250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8Z73_RS15260	COG0628	permease
H8Z73_RS15270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8Z73_RS15280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8Z73_RS15300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8Z73_RS15305	COG0271	Belongs to the BolA IbaG family
H8Z73_RS15315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8Z73_RS15325	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H8Z73_RS15330	COG1137	ATPase activity
H8Z73_RS15345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z73_RS15350	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z73_RS15355	COG1660	Displays ATPase and GTPase activities
H8Z73_RS15365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z73_RS15370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z73_RS15375	COG2239	Acts as a magnesium transporter
H8Z73_RS15390	COG1294	oxidase, subunit
H8Z73_RS15395	COG1271	oxidase subunit
H8Z73_RS15405	COG1113	amino acid transport
H8Z73_RS15425	COG2197	response regulator
H8Z73_RS15435	COG0531	amino acid
H8Z73_RS15455	COG1234	tRNA 3'-trailer cleavage
H8Z73_RS15490	COG2814	Major facilitator Superfamily
H8Z73_RS15500	COG0754	glutathionylspermidine amidase activity
H8Z73_RS15525	COG1842	Phage shock protein A
H8Z73_RS15535	COG0259	pyridoxamine-phosphate oxidase activity
H8Z73_RS15540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8Z73_RS15545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8Z73_RS15555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8Z73_RS15635	COG0477	Major facilitator Superfamily
H8Z73_RS15655	COG2198	Histidine kinase
H8Z73_RS15655	COG0784	Response regulator, receiver
H8Z73_RS15655	COG2205	protein histidine kinase activity
H8Z73_RS15660	COG2353	YceI-like domain
H8Z73_RS15680	COG1760	l-serine dehydratase
H8Z73_RS15690	COG0527	aspartate kinase activity
H8Z73_RS15690	COG0460	homoserine dehydrogenase
H8Z73_RS15695	COG0626	cystathionine gamma-synthase activity
H8Z73_RS15700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z73_RS15705	COG0739	heme binding
H8Z73_RS15710	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8Z73_RS15715	COG1272	protein, Hemolysin III
H8Z73_RS15720	COG2982	Protein involved in outer membrane biogenesis
H8Z73_RS15725	COG0517	IMP dehydrogenase activity
H8Z73_RS15725	COG0516	GMP reductase activity
H8Z73_RS15730	COG0463	Glycosyl transferase, family 2
H8Z73_RS15735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z73_RS15740	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8Z73_RS15750	COG4771	TonB-dependent receptor
H8Z73_RS15770	COG1309	transcriptional regulator
H8Z73_RS15780	COG1960	acyl-CoA dehydrogenase activity
H8Z73_RS15810	COG0509	glycine decarboxylation via glycine cleavage system
H8Z73_RS15815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8Z73_RS15825	COG0330	HflC and HflK could
H8Z73_RS15830	COG1742	UPF0060 membrane protein
H8Z73_RS15835	COG3956	TIGRFAM MazG family protein
H8Z73_RS15845	COG0494	nUDIX hydrolase
H8Z73_RS15855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8Z73_RS15860	COG0837	glucose binding
H8Z73_RS15875	COG1388	LysM domain
H8Z73_RS15875	COG3858	chitin binding
H8Z73_RS15880	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H8Z73_RS15890	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z73_RS15905	COG0531	amino acid
H8Z73_RS15915	COG1486	melibiose metabolic process
H8Z73_RS15925	COG3537	Alpha-1,2-mannosidase
H8Z73_RS15960	COG3142	Participates in the control of copper homeostasis
H8Z73_RS15965	COG1446	asparaginase
H8Z73_RS15985	COG0643	Histidine kinase
H8Z73_RS15985	COG0784	Response regulator, receiver
H8Z73_RS15985	COG2198	Histidine kinase
H8Z73_RS15990	COG0840	transmembrane signaling receptor activity
H8Z73_RS15995	COG0835	chemotaxis
H8Z73_RS16010	COG0189	ligase activity
H8Z73_RS16020	COG1397	ADP-ribosylglycohydrolase
H8Z73_RS16030	COG1199	ATP-dependent helicase activity
H8Z73_RS16040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z73_RS16045	COG1215	transferase activity, transferring glycosyl groups
H8Z73_RS16055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z73_RS16065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H8Z73_RS16070	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H8Z73_RS16075	COG0535	radical SAM domain protein
H8Z73_RS16080	COG0535	radical SAM domain protein
H8Z73_RS16095	COG0837	glucose binding
H8Z73_RS16110	COG1643	Atp-dependent helicase
H8Z73_RS16115	COG0783	Belongs to the Dps family
H8Z73_RS16120	COG0514	ATP-dependent DNA helicase (RecQ)
H8Z73_RS16150	COG0840	transmembrane signaling receptor activity
H8Z73_RS16170	COG3920	Histidine kinase
H8Z73_RS16175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8Z73_RS16185	COG0602	queuosine metabolic process
H8Z73_RS16195	COG2885	chlorophyll binding
H8Z73_RS16200	COG0823	Involved in the tonB-independent uptake of proteins
H8Z73_RS16210	COG0848	biopolymer transport protein
H8Z73_RS16220	COG0824	Thioesterase
H8Z73_RS16225	COG2255	four-way junction helicase activity
H8Z73_RS16235	COG3158	transport of potassium into the cell
H8Z73_RS16240	COG0632	four-way junction helicase activity
H8Z73_RS16245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8Z73_RS16250	COG0217	transcriptional regulatory protein
H8Z73_RS16265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8Z73_RS16280	COG0477	Major facilitator Superfamily
H8Z73_RS16320	COG0488	(ABC) transporter
H8Z73_RS16350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z73_RS16350	COG4651	solute:proton antiporter activity
H8Z73_RS16375	COG4772	TonB-dependent receptor
H8Z73_RS16385	COG4264	IucA IucC family
H8Z73_RS16400	COG0019	diaminopimelate decarboxylase activity
H8Z73_RS16430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8Z73_RS16440	COG1492	cobalamin metabolic process
H8Z73_RS16450	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z73_RS16470	COG4206	TonB-dependent receptor
H8Z73_RS16475	COG0542	response to heat
H8Z73_RS16480	COG1116	anion transmembrane transporter activity
H8Z73_RS16485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z73_RS16490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8Z73_RS16495	COG0667	Aldo Keto reductase
H8Z73_RS16500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z73_RS16505	COG4771	TonB-dependent receptor
H8Z73_RS16510	COG2827	Endonuclease containing a URI domain
H8Z73_RS16550	COG1877	trehalose-phosphatase activity
H8Z73_RS16555	COG3387	PFAM Glycoside hydrolase 15-related
H8Z73_RS16570	COG0840	transmembrane signaling receptor activity
H8Z73_RS16575	COG3011	Protein conserved in bacteria
H8Z73_RS16590	COG0564	pseudouridine synthase activity
H8Z73_RS16595	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z73_RS16605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z73_RS16605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8Z73_RS16625	COG2951	lytic endotransglycosylase activity
H8Z73_RS16630	COG4644	lycopene metabolic process
H8Z73_RS16655	COG2369	cell adhesion
H8Z73_RS16675	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8Z73_RS16680	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z73_RS16695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z73_RS16725	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8Z73_RS16730	COG0237	dephospho-CoA kinase activity
H8Z73_RS16765	COG5002	protein histidine kinase activity
H8Z73_RS16770	COG0745	RESPONSE REGULATOR receiver
H8Z73_RS16915	COG2022	thiamine diphosphate biosynthetic process
H8Z73_RS16925	COG3273	potassium ion transport
H8Z73_RS16925	COG0471	metal ion transport
H8Z73_RS16945	COG1970	mechanosensitive ion channel activity
H8Z73_RS16965	COG3250	beta-galactosidase activity
H8Z73_RS16970	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z73_RS16985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z73_RS16995	COG0308	aminopeptidase N
H8Z73_RS17030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z73_RS17040	COG0529	Catalyzes the synthesis of activated sulfate
H8Z73_RS17040	COG2895	sulfate adenylyltransferase (ATP) activity
H8Z73_RS17045	COG0175	sulfate reduction
H8Z73_RS17050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z73_RS17055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8Z73_RS17060	COG0175	sulfate reduction
H8Z73_RS17080	COG2205	protein histidine kinase activity
H8Z73_RS17080	COG0784	Response regulator, receiver
H8Z73_RS17080	COG2198	Histidine kinase
H8Z73_RS17095	COG1648	precorrin-2 dehydrogenase activity
H8Z73_RS17095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z73_RS17110	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8Z73_RS17115	COG3588	fructose-bisphosphate aldolase
H8Z73_RS17120	COG0469	pyruvate kinase activity
H8Z73_RS17130	COG0126	phosphoglycerate kinase activity
H8Z73_RS17150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8Z73_RS17160	COG3047	cAMP biosynthetic process
H8Z73_RS17165	COG3047	cAMP biosynthetic process
H8Z73_RS17175	COG3453	Protein conserved in bacteria
H8Z73_RS17175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z73_RS17180	COG0725	ABC transporter, periplasmic molybdate-binding protein
H8Z73_RS17185	COG4149	molybdate abc transporter
H8Z73_RS17190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H8Z73_RS17225	COG1376	ErfK ybiS ycfS ynhG family protein
H8Z73_RS17230	COG0739	heme binding
H8Z73_RS17240	COG4773	Receptor
H8Z73_RS17245	COG0596	Alpha beta hydrolase
H8Z73_RS17250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8Z73_RS17255	COG1301	dicarboxylic acid transport
H8Z73_RS17265	COG2304	oxidoreductase activity
H8Z73_RS17285	COG0714	Associated with various cellular activities
H8Z73_RS17315	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8Z73_RS17340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8Z73_RS17350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z73_RS17360	COG0194	GDP metabolic process
H8Z73_RS17365	COG1561	YicC-like family, N-terminal region
H8Z73_RS17370	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8Z73_RS17380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8Z73_RS17385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8Z73_RS17400	COG0006	proline dipeptidase activity
H8Z73_RS17410	COG0006	proline dipeptidase activity
H8Z73_RS17415	COG3079	Belongs to the UPF0149 family
H8Z73_RS17435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8Z73_RS17445	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8Z73_RS17455	COG2912	Transglutaminase-like superfamily
H8Z73_RS17460	COG1773	rubredoxin
H8Z73_RS17465	COG0352	thiamine-phosphate diphosphorylase activity
H8Z73_RS17480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z73_RS17495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z73_RS17525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8Z73_RS17530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z73_RS17540	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS17550	COG0671	phosphoesterase, PA-phosphatase related
H8Z73_RS17555	COG3781	membrane
H8Z73_RS17565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z73_RS17570	COG0563	adenylate kinase activity
H8Z73_RS17585	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H8Z73_RS17595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8Z73_RS17615	COG3710	Transcriptional regulator
H8Z73_RS17620	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8Z73_RS17630	COG0840	transmembrane signaling receptor activity
H8Z73_RS17635	COG0405	Gamma-glutamyltransferase
H8Z73_RS17640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8Z73_RS17660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8Z73_RS17665	COG0473	3-isopropylmalate dehydrogenase activity
H8Z73_RS17670	COG0066	3-isopropylmalate dehydratase activity
H8Z73_RS17675	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8Z73_RS17695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z73_RS17700	COG1538	Outer membrane efflux protein
H8Z73_RS17705	COG1519	Transferase
H8Z73_RS17710	COG1560	Kdo2-lipid A biosynthetic process
H8Z73_RS17735	COG0280	phosphate acetyltransferase
H8Z73_RS17735	COG0281	malic enzyme
H8Z73_RS17740	COG1301	dicarboxylic acid transport
H8Z73_RS17765	COG0583	DNA-binding transcription factor activity
H8Z73_RS17770	COG0667	Aldo Keto reductase
H8Z73_RS17785	COG2197	response regulator
H8Z73_RS17795	COG0642	Histidine kinase
H8Z73_RS17810	COG2851	Citrate transporter
H8Z73_RS17815	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS17820	COG1609	Transcriptional regulator
H8Z73_RS17825	COG2211	Major facilitator Superfamily
H8Z73_RS17850	COG1162	GTPase activity
H8Z73_RS17870	COG4773	Receptor
H8Z73_RS17875	COG0726	polysaccharide deacetylase
H8Z73_RS17880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z73_RS17910	COG1307	EDD domain protein, DegV family
H8Z73_RS17915	COG0242	peptide deformylase activity
H8Z73_RS17935	COG0457	Tetratricopeptide repeat
H8Z73_RS17940	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H8Z73_RS17945	COG1215	transferase activity, transferring glycosyl groups
H8Z73_RS17950	COG1215	transferase activity, transferring glycosyl groups
H8Z73_RS17965	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H8Z73_RS18010	COG2188	Transcriptional regulator
H8Z73_RS18025	COG1450	Type ii and iii secretion system protein
H8Z73_RS18040	COG3166	PFAM Fimbrial assembly family protein
H8Z73_RS18045	COG3156	type II secretion system protein K
H8Z73_RS18050	COG4795	General secretion pathway protein
H8Z73_RS18055	COG2165	general secretion pathway protein
H8Z73_RS18060	COG4970	Tfp pilus assembly protein FimT
H8Z73_RS18065	COG2165	general secretion pathway protein
H8Z73_RS18070	COG1459	type II secretion system
H8Z73_RS18075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z73_RS18080	COG1404	Belongs to the peptidase S8 family
H8Z73_RS18085	COG5295	Hep Hag repeat protein
H8Z73_RS18090	COG1404	Belongs to the peptidase S8 family
H8Z73_RS18095	COG5295	Hep Hag repeat protein
H8Z73_RS18100	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8Z73_RS18100	COG0047	phosphoribosylformylglycinamidine synthase activity
H8Z73_RS18105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z73_RS18110	COG4974	Belongs to the 'phage' integrase family
H8Z73_RS18125	COG0795	lipopolysaccharide-transporting ATPase activity
H8Z73_RS18135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z73_RS18150	COG0525	valine-tRNA ligase activity
H8Z73_RS18180	COG1183	phosphatidylcholine synthase activity
H8Z73_RS18190	COG0442	prolyl-tRNA aminoacylation
H8Z73_RS18205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z73_RS18210	COG1127	ABC transporter
H8Z73_RS18215	COG3218	ABC-type transport auxiliary lipoprotein component
H8Z73_RS18215	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z73_RS18250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z73_RS18255	COG0662	Cupin 2, conserved barrel domain protein
H8Z73_RS18255	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H8Z73_RS18285	COG2086	electron transfer activity
H8Z73_RS18300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z73_RS18300	COG0546	phosphoglycolate phosphatase activity
H8Z73_RS18305	COG0277	FAD linked oxidase domain protein
H8Z73_RS18310	COG0300	oxidoreductase activity
H8Z73_RS18320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z73_RS18340	COG2226	methyltransferase
H8Z73_RS18350	COG3754	Rhamnan synthesis protein F
H8Z73_RS18355	COG1216	Glycosyl transferase, family 2
H8Z73_RS18355	COG0438	transferase activity, transferring glycosyl groups
H8Z73_RS18360	COG0110	maltose O-acetyltransferase activity
H8Z73_RS18375	COG0626	cystathionine gamma-synthase activity
H8Z73_RS18405	COG0625	glutathione transferase activity
H8Z73_RS18415	COG0513	Belongs to the DEAD box helicase family
H8Z73_RS18425	COG4206	TonB-dependent receptor
H8Z73_RS18430	COG0720	synthase
H8Z73_RS18440	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8Z73_RS18445	COG1956	GAF domain-containing protein
H8Z73_RS18455	COG2819	hydrolase of the alpha beta superfamily
H8Z73_RS18470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z73_RS18475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z73_RS18490	COG0339	signal peptide processing
H8Z73_RS18545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z73_RS18550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_RS18555	COG1136	(ABC) transporter
H8Z73_RS18555	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z73_RS18560	COG0577	efflux transmembrane transporter activity
H8Z73_RS18565	COG0577	efflux transmembrane transporter activity
H8Z73_RS18580	COG4191	Histidine kinase
H8Z73_RS18585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8Z73_RS18600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8Z73_RS18605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8Z73_RS18610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8Z73_RS18615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8Z73_RS18620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8Z73_RS18625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8Z73_RS18635	COG0356	it plays a direct role in the translocation of protons across the membrane
H8Z73_RS18655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z73_RS18665	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8Z73_RS18705	COG2011	ABC-type metal ion transport system permease component
H8Z73_RS18710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8Z73_RS18715	COG0697	spore germination
H8Z73_RS18720	COG1666	GTP binding
H8Z73_RS18730	COG5002	protein histidine kinase activity
H8Z73_RS18730	COG0784	Response regulator, receiver
H8Z73_RS18730	COG2198	Histidine kinase
H8Z73_RS18750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z73_RS18755	COG1187	pseudouridine synthase activity
H8Z73_RS18760	COG2813	Specifically methylates the guanine in position
H8Z73_RS18780	COG2202	Pas domain
H8Z73_RS18780	COG2205	protein histidine kinase activity
H8Z73_RS18800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8Z73_RS18805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z73_RS18860	COG0842	Transport permease protein
H8Z73_RS18865	COG1131	(ABC) transporter
H8Z73_RS18870	COG0025	NhaP-type Na H and K H
H8Z73_RS18875	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8Z73_RS18880	COG1573	uracil-dna glycosylase
H8Z73_RS18890	COG3384	dioxygenase
H8Z73_RS18900	COG0583	DNA-binding transcription factor activity
H8Z73_RS18910	COG0667	Aldo Keto reductase
H8Z73_RS18920	COG3590	peptidase
H8Z73_RS18940	COG0531	amino acid
H8Z73_RS18955	COG2972	Histidine kinase
H8Z73_RS18970	COG3685	Protein conserved in bacteria
H8Z73_RS18975	COG3546	catalase activity
H8Z73_RS19020	COG1271	oxidase subunit
H8Z73_RS19025	COG1294	oxidase, subunit
H8Z73_RS19040	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS19045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8Z73_RS19065	COG1132	(ABC) transporter
H8Z73_RS19080	COG1063	alcohol dehydrogenase
H8Z73_RS19155	COG0251	oxidation-reduction process
H8Z73_RS19170	COG0840	transmembrane signaling receptor activity
H8Z73_RS19185	COG0583	DNA-binding transcription factor activity
H8Z73_RS19190	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z73_RS19235	COG0024	Methionine aminopeptidase
H8Z73_RS19270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z73_RS19275	COG1490	D-aminoacyl-tRNA deacylase activity
H8Z73_RS19280	COG1560	Kdo2-lipid A biosynthetic process
H8Z73_RS19330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8Z73_RS19330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z73_RS19335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8Z73_RS19340	COG0242	peptide deformylase activity
H8Z73_RS19345	COG1652	LysM domain
H8Z73_RS19350	COG0758	DNA mediated transformation
H8Z73_RS19370	COG1754	DNA topoisomerase type I activity
H8Z73_RS19370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z73_RS19375	COG0009	L-threonylcarbamoyladenylate synthase
H8Z73_RS19390	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS19400	COG0616	signal peptide processing
H8Z73_RS19405	COG0534	Mate efflux family protein
H8Z73_RS19425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8Z73_RS19430	COG0625	glutathione transferase activity
H8Z73_RS19445	COG1252	NADH dehydrogenase
H8Z73_RS19450	COG2860	membrane
H8Z73_RS19455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z73_RS19460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H8Z73_RS19465	COG2201	protein-glutamate methylesterase activity
H8Z73_RS19470	COG2177	Part of the ABC transporter FtsEX involved in
H8Z73_RS19475	COG2884	Cell division ATP-binding protein ftsE
H8Z73_RS19480	COG0513	Belongs to the DEAD box helicase family
H8Z73_RS19485	COG3118	belongs to the thioredoxin family
H8Z73_RS19490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H8Z73_RS19495	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H8Z73_RS19500	COG0583	DNA-binding transcription factor activity
H8Z73_RS19545	COG1518	maintenance of DNA repeat elements
H8Z73_RS19550	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H8Z73_RS19560	COG1652	LysM domain
H8Z73_RS19565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z73_RS19565	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z73_RS19570	COG1473	amidohydrolase
H8Z73_RS19575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_RS19580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z73_RS19590	COG5383	Protein conserved in bacteria
H8Z73_RS19630	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8Z73_RS19635	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8Z73_RS19645	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z73_RS19655	COG0531	amino acid
H8Z73_RS19670	COG4682	membrane
H8Z73_RS19675	COG2133	pyrroloquinoline quinone binding
H8Z73_RS19685	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8Z73_RS19690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8Z73_RS19700	COG1610	YqeY-like protein
H8Z73_RS19705	COG1295	ribonuclease BN
H8Z73_RS19710	COG0358	DNA primase activity
H8Z73_RS19725	COG0109	protoheme IX farnesyltransferase activity
H8Z73_RS19755	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H8Z73_RS19770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8Z73_RS19810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8Z73_RS19815	COG0739	heme binding
H8Z73_RS19820	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H8Z73_RS19830	COG2223	nitrite transmembrane transporter activity
H8Z73_RS19835	COG0708	Exodeoxyribonuclease III
H8Z73_RS19840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8Z73_RS19850	COG1192	Involved in chromosome partitioning
H8Z73_RS19855	COG1475	DNA binding
H8Z73_RS19870	COG0463	Glycosyl transferase, family 2
H8Z73_RS19890	COG0756	dUTP diphosphatase activity
H8Z73_RS19895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8Z73_RS19900	COG2003	Belongs to the UPF0758 family
H8Z73_RS19905	COG0018	arginyl-trna synthetase
H8Z73_RS19920	COG4221	oxidoreductase activity
H8Z73_RS19925	COG2755	lipolytic protein G-D-S-L family
H8Z73_RS19925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8Z73_RS19935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z73_RS19940	COG1166	arginine decarboxylase activity
H8Z73_RS19945	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8Z73_RS19980	COG0606	chelatase, subunit chli
H8Z73_RS19995	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H8Z73_RS20020	COG1690	Belongs to the RtcB family
H8Z73_RS20060	COG1090	epimerase
H8Z73_RS20070	COG0642	Histidine kinase
H8Z73_RS20095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z73_RS20120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z73_RS20125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z73_RS20140	COG0753	catalase activity
H8Z73_RS20155	COG2197	response regulator
H8Z73_RS20160	COG4585	Histidine kinase
H8Z73_RS20165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_RS20170	COG1136	(ABC) transporter
H8Z73_RS20195	COG0697	spore germination
H8Z73_RS20210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z73_RS20215	COG0180	Tryptophanyl-tRNA synthetase
H8Z73_RS20220	COG3237	CsbD-like
H8Z73_RS20260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8Z73_RS20275	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8Z73_RS20320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z73_RS20340	COG1199	ATP-dependent helicase activity
H8Z73_RS20355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8Z73_RS20420	COG0625	glutathione transferase activity
H8Z73_RS20455	COG4555	ABC transporter
H8Z73_RS20465	COG1476	TRANSCRIPTIONal
H8Z73_RS20510	COG0543	2 iron, 2 sulfur cluster binding
H8Z73_RS20510	COG0633	Ferredoxin
H8Z73_RS20515	COG1131	(ABC) transporter
H8Z73_RS20520	COG0842	Transport permease protein
H8Z73_RS20530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8Z73_RS20565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z73_RS20570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z73_RS20580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8Z73_RS20580	COG1042	CoA-binding domain protein
H8Z73_RS20580	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z73_RS20585	COG2239	Acts as a magnesium transporter
H8Z73_RS20600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z73_RS20605	COG3387	PFAM Glycoside hydrolase 15-related
H8Z73_RS20620	COG3100	YcgL domain-containing protein
H8Z73_RS20625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8Z73_RS20635	COG0463	Glycosyl transferase, family 2
H8Z73_RS20655	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS20690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z73_RS20705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8Z73_RS20730	COG4946	Tricorn protease homolog
H8Z73_RS20730	COG0823	Involved in the tonB-independent uptake of proteins
H8Z73_RS20730	COG1506	peptidase
H8Z73_RS20745	COG0408	coproporphyrinogen oxidase activity
H8Z73_RS20780	COG2815	serine threonine protein kinase
H8Z73_RS20780	COG0515	serine threonine protein kinase
H8Z73_RS20785	COG0631	protein serine/threonine phosphatase activity
H8Z73_RS20965	COG0210	DNA helicase
H8Z73_RS20975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z73_RS20980	COG0583	DNA-binding transcription factor activity
H8Z73_RS20985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z73_RS20995	COG2159	amidohydrolase
H8Z73_RS21015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_RS21035	COG0357	Ribosomal RNA small subunit methyltransferase G
H8Z73_RS21040	COG3540	Alkaline phosphatase
H8Z73_RS21050	COG2091	lysine biosynthetic process via aminoadipic acid
H8Z73_RS21065	COG0708	Exodeoxyribonuclease III
H8Z73_RS21070	COG1940	carbohydrate kinase activity
H8Z73_RS21070	COG1846	Transcriptional regulator
H8Z73_RS21080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z73_RS21090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8Z73_RS21095	COG3162	membrane
H8Z73_RS21105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8Z73_RS21130	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z73_RS21150	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_RS21155	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8Z73_RS21160	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z73_RS21165	COG3254	rhamnose metabolic process
H8Z73_RS21170	COG0738	Major facilitator superfamily
H8Z73_RS21175	COG1414	Transcriptional regulator
H8Z73_RS21180	COG1971	Probably functions as a manganese efflux pump
H8Z73_RS21185	COG2205	protein histidine kinase activity
H8Z73_RS21195	COG3459	Glycosyltransferase 36 associated
H8Z73_RS21200	COG2211	Major facilitator Superfamily
H8Z73_RS21205	COG3265	gluconokinase activity
H8Z73_RS21210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z73_RS21230	COG2911	Protein conserved in bacteria
H8Z73_RS21235	COG0729	surface antigen
H8Z73_RS21260	COG0752	glycyl-tRNA synthetase alpha subunit
H8Z73_RS21265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z73_RS21275	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z73_RS21275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z73_RS21285	COG0805	protein transport
H8Z73_RS21290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z73_RS21295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z73_RS21305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8Z73_RS21325	COG2974	May be involved in recombination
H8Z73_RS21330	COG0037	tRNA processing
H8Z73_RS21335	COG2115	Belongs to the xylose isomerase family
H8Z73_RS21345	COG3661	Belongs to the glycosyl hydrolase 67 family
H8Z73_RS21355	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z73_RS21365	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z73_RS21370	COG0246	Mannitol dehydrogenase
H8Z73_RS21415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z73_RS21445	COG3386	PFAM SMP-30 Gluconolaconase
H8Z73_RS21455	COG3250	beta-galactosidase activity
H8Z73_RS21460	COG1904	glucuronate isomerase
H8Z73_RS21480	COG3693	PFAM glycoside hydrolase, family 10
H8Z73_RS21495	COG2211	Major facilitator Superfamily
H8Z73_RS21575	COG2937	Belongs to the GPAT DAPAT family
H8Z73_RS21605	COG0284	orotidine-5'-phosphate decarboxylase activity
H8Z73_RS21610	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H8Z73_RS21615	COG3132	Protein of unknown function, DUF480
H8Z73_RS21630	COG0210	DNA helicase
H8Z73_RS21635	COG1435	thymidine kinase activity
H8Z73_RS21645	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H8Z73_RS21655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8Z73_RS21685	COG3135	benzoate transporter
H8Z73_RS21705	COG0676	glucose-6-phosphate 1-epimerase activity
H8Z73_RS21715	COG3012	SEC-C Motif Domain Protein
H8Z73_RS21720	COG0730	response to heat
H8Z73_RS21745	COG0302	gtp cyclohydrolase
H8Z73_RS21760	COG1566	PFAM secretion protein HlyD family protein
H8Z73_RS21770	COG1289	transmembrane transporter activity
H8Z73_RS21775	COG0477	Major facilitator Superfamily
H8Z73_RS21785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z73_RS21805	COG4691	Plasmid stability protein
H8Z73_RS21810	COG1487	ribonuclease activity
H8Z73_RS21845	COG0564	pseudouridine synthase activity
H8Z73_RS21900	COG1074	ATP-dependent DNA helicase activity
H8Z73_RS21905	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H8Z73_RS21920	COG1127	ABC transporter
H8Z73_RS21925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z73_RS21930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z73_RS21945	COG2853	Lipoprotein
H8Z73_RS21955	COG0386	Belongs to the glutathione peroxidase family
H8Z73_RS21965	COG1322	Protein conserved in bacteria
H8Z73_RS21970	COG0604	alcohol dehydrogenase
H8Z73_RS21985	COG0625	glutathione transferase activity
H8Z73_RS21995	COG0531	amino acid
H8Z73_RS22000	COG3537	Alpha-1,2-mannosidase
H8Z73_RS22010	COG3706	GGDEF domain
H8Z73_RS22015	COG3835	regulator
H8Z73_RS22020	COG1929	Belongs to the glycerate kinase type-1 family
H8Z73_RS22025	COG2271	Major facilitator Superfamily
H8Z73_RS22040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z73_RS22045	COG0861	Integral membrane protein TerC family
H8Z73_RS22055	COG0584	glycerophosphoryl diester phosphodiesterase
H8Z73_RS22070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8Z73_RS22075	COG0726	polysaccharide deacetylase
H8Z73_RS22080	COG0706	membrane insertase activity
H8Z73_RS22085	COG0594	ribonuclease P activity
H8Z73_RS22100	COG2188	Transcriptional regulator
H8Z73_RS22120	COG2871	sodium ion transport
H8Z73_RS22145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z73_RS22150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_RS22165	COG2217	Heavy metal translocating P-type atpase
H8Z73_RS22170	COG2217	Heavy metal translocating P-type atpase
H8Z73_RS22180	COG1063	alcohol dehydrogenase
H8Z73_RS22375	COG1192	Involved in chromosome partitioning
H8Z73_RS22550	COG3550	peptidyl-serine autophosphorylation
H8Z73_RS22650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z73_RS22695	COG0741	lytic transglycosylase activity
H8Z73_RS22790	COG1475	DNA binding
H8Z73_RS22830	COG0629	single-stranded DNA binding
H8Z73_RS22865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8Z73_RS23090	COG4644	lycopene metabolic process
H8Z73_RS23140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8Z73_RS23165	COG2132	Multicopper oxidase
H8Z73_RS23200	COG0010	Belongs to the arginase family
H8Z73_RS23205	COG2986	histidine ammonia-lyase
H8Z73_RS23325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z73_RS23345	COG3318	Belongs to the UPF0149 family
H8Z73_RS23345	COG3012	SEC-C Motif Domain Protein
H8Z73_RS23365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z73_RS23370	COG4456	Virulence-associated protein
H8Z73_RS23545	COG0489	protein tyrosine kinase activity
H8Z73_RS23580	COG4680	protein conserved in bacteria
H8Z73_RS23625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z73_RS23665	COG3012	SEC-C Motif Domain Protein
H8Z73_RS23665	COG3318	Belongs to the UPF0149 family
H8Z73_RS23685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z73_RS23705	COG3451	type IV secretory pathway VirB4
H8Z73_RS23715	COG3838	Conjugal transfer protein Trbc
H8Z73_RS23720	COG4962	Type ii secretion system protein e
H8Z73_RS23780	COG3318	Belongs to the UPF0149 family
H8Z73_RS23780	COG3012	SEC-C Motif Domain Protein
H8Z73_RS23830	COG1192	Involved in chromosome partitioning
H8Z73_RS23940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z73_RS23950	COG1487	ribonuclease activity
H8Z73_RS23965	COG3505	Type IV secretory pathway VirD4
H8Z73_RS24005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z73_RS24030	COG3318	Belongs to the UPF0149 family
H8Z73_RS24030	COG3012	SEC-C Motif Domain Protein