locus-tag	class	description
H8Z71_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H8Z71_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8Z71_RS00020	COG0187	DNA topoisomerase II activity
H8Z71_RS00030	COG0501	Belongs to the peptidase M48B family
H8Z71_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8Z71_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z71_RS00115	COG0793	Belongs to the peptidase S41A family
H8Z71_RS00120	COG4942	peptidase
H8Z71_RS00130	COG2234	aminopeptidase activity
H8Z71_RS00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z71_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z71_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z71_RS00165	COG1064	alcohol dehydrogenase
H8Z71_RS00175	COG0493	'glutamate synthase
H8Z71_RS00180	COG0070	glutamate synthase
H8Z71_RS00180	COG0067	glutamate synthase
H8Z71_RS00180	COG0069	glutamate synthase activity
H8Z71_RS00230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8Z71_RS00245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H8Z71_RS00250	COG0438	transferase activity, transferring glycosyl groups
H8Z71_RS00250	COG0297	glycogen (starch) synthase activity
H8Z71_RS00270	COG0367	asparagine synthase
H8Z71_RS00300	COG1132	(ABC) transporter
H8Z71_RS00330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z71_RS00415	COG1111	helicase
H8Z71_RS00415	COG1205	dead DEAH box helicase
H8Z71_RS00420	COG1272	protein, Hemolysin III
H8Z71_RS00440	COG0300	oxidoreductase activity
H8Z71_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS00465	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8Z71_RS00485	COG1119	ATPase activity
H8Z71_RS00495	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8Z71_RS00505	COG1522	sequence-specific DNA binding
H8Z71_RS00510	COG3186	Phenylalanine-4-hydroxylase
H8Z71_RS00525	COG2755	lipolytic protein G-D-S-L family
H8Z71_RS00535	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS00540	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H8Z71_RS00545	COG1609	Transcriptional regulator
H8Z71_RS00550	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z71_RS00565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H8Z71_RS00575	COG0657	acetylesterase activity
H8Z71_RS00575	COG2755	lipolytic protein G-D-S-L family
H8Z71_RS00595	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z71_RS00600	COG0366	Alpha amylase catalytic
H8Z71_RS00605	COG0366	Alpha amylase catalytic
H8Z71_RS00750	COG0631	protein serine/threonine phosphatase activity
H8Z71_RS00755	COG2815	serine threonine protein kinase
H8Z71_RS00755	COG0515	serine threonine protein kinase
H8Z71_RS00790	COG0408	coproporphyrinogen oxidase activity
H8Z71_RS00805	COG0823	Involved in the tonB-independent uptake of proteins
H8Z71_RS00805	COG1506	peptidase
H8Z71_RS00805	COG4946	Tricorn protease homolog
H8Z71_RS00830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8Z71_RS00845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z71_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS00900	COG0463	Glycosyl transferase, family 2
H8Z71_RS00910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8Z71_RS00915	COG3100	YcgL domain-containing protein
H8Z71_RS00930	COG3387	PFAM Glycoside hydrolase 15-related
H8Z71_RS00935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z71_RS00950	COG2239	Acts as a magnesium transporter
H8Z71_RS00955	COG1042	CoA-binding domain protein
H8Z71_RS00955	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z71_RS00955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8Z71_RS00965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z71_RS00970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z71_RS01005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8Z71_RS01015	COG0842	Transport permease protein
H8Z71_RS01020	COG1131	(ABC) transporter
H8Z71_RS01025	COG0543	2 iron, 2 sulfur cluster binding
H8Z71_RS01025	COG0633	Ferredoxin
H8Z71_RS01070	COG1476	TRANSCRIPTIONal
H8Z71_RS01080	COG4555	ABC transporter
H8Z71_RS01115	COG0625	glutathione transferase activity
H8Z71_RS01180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8Z71_RS01195	COG1199	ATP-dependent helicase activity
H8Z71_RS01215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z71_RS01260	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8Z71_RS01275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8Z71_RS01315	COG3237	CsbD-like
H8Z71_RS01320	COG0180	Tryptophanyl-tRNA synthetase
H8Z71_RS01325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z71_RS01340	COG0697	spore germination
H8Z71_RS01365	COG1136	(ABC) transporter
H8Z71_RS01370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z71_RS01375	COG4585	Histidine kinase
H8Z71_RS01380	COG2197	response regulator
H8Z71_RS01395	COG0753	catalase activity
H8Z71_RS01410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z71_RS01415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z71_RS01440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z71_RS01465	COG0642	Histidine kinase
H8Z71_RS01475	COG1090	epimerase
H8Z71_RS01515	COG1690	Belongs to the RtcB family
H8Z71_RS01540	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H8Z71_RS01555	COG0606	chelatase, subunit chli
H8Z71_RS01590	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8Z71_RS01595	COG1166	arginine decarboxylase activity
H8Z71_RS01600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z71_RS01610	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8Z71_RS01610	COG2755	lipolytic protein G-D-S-L family
H8Z71_RS01615	COG4221	oxidoreductase activity
H8Z71_RS01630	COG0018	arginyl-trna synthetase
H8Z71_RS01635	COG2003	Belongs to the UPF0758 family
H8Z71_RS01640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8Z71_RS01645	COG0756	dUTP diphosphatase activity
H8Z71_RS01665	COG0463	Glycosyl transferase, family 2
H8Z71_RS01680	COG1475	DNA binding
H8Z71_RS01685	COG1192	Involved in chromosome partitioning
H8Z71_RS01695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8Z71_RS01700	COG0708	Exodeoxyribonuclease III
H8Z71_RS01705	COG2223	nitrite transmembrane transporter activity
H8Z71_RS01715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H8Z71_RS01720	COG0739	heme binding
H8Z71_RS01725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8Z71_RS01765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8Z71_RS01780	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H8Z71_RS01810	COG0109	protoheme IX farnesyltransferase activity
H8Z71_RS01825	COG0358	DNA primase activity
H8Z71_RS01830	COG1295	ribonuclease BN
H8Z71_RS01835	COG1610	YqeY-like protein
H8Z71_RS01845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8Z71_RS01850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8Z71_RS01860	COG2133	pyrroloquinoline quinone binding
H8Z71_RS01865	COG4682	membrane
H8Z71_RS01880	COG0531	amino acid
H8Z71_RS01890	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z71_RS01900	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8Z71_RS01905	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8Z71_RS01945	COG5383	Protein conserved in bacteria
H8Z71_RS01955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z71_RS01960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z71_RS01965	COG1473	amidohydrolase
H8Z71_RS01970	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z71_RS01970	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z71_RS01975	COG1652	LysM domain
H8Z71_RS01985	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H8Z71_RS01990	COG1518	maintenance of DNA repeat elements
H8Z71_RS02035	COG0583	DNA-binding transcription factor activity
H8Z71_RS02040	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H8Z71_RS02045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H8Z71_RS02050	COG3118	belongs to the thioredoxin family
H8Z71_RS02055	COG0513	Belongs to the DEAD box helicase family
H8Z71_RS02060	COG2884	Cell division ATP-binding protein ftsE
H8Z71_RS02065	COG2177	Part of the ABC transporter FtsEX involved in
H8Z71_RS02070	COG2201	protein-glutamate methylesterase activity
H8Z71_RS02075	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H8Z71_RS02080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z71_RS02085	COG2860	membrane
H8Z71_RS02090	COG1252	NADH dehydrogenase
H8Z71_RS02105	COG0625	glutathione transferase activity
H8Z71_RS02110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8Z71_RS02130	COG0534	Mate efflux family protein
H8Z71_RS02135	COG0616	signal peptide processing
H8Z71_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS02160	COG0009	L-threonylcarbamoyladenylate synthase
H8Z71_RS02165	COG1754	DNA topoisomerase type I activity
H8Z71_RS02165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z71_RS02185	COG0758	DNA mediated transformation
H8Z71_RS02190	COG1652	LysM domain
H8Z71_RS02195	COG0242	peptide deformylase activity
H8Z71_RS02200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8Z71_RS02205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z71_RS02205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8Z71_RS02255	COG1560	Kdo2-lipid A biosynthetic process
H8Z71_RS02260	COG1490	D-aminoacyl-tRNA deacylase activity
H8Z71_RS02265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z71_RS02455	COG3179	chitinase
H8Z71_RS02500	COG4695	Portal protein
H8Z71_RS02530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z71_RS02575	COG0024	Methionine aminopeptidase
H8Z71_RS02620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z71_RS02625	COG0583	DNA-binding transcription factor activity
H8Z71_RS02640	COG0840	transmembrane signaling receptor activity
H8Z71_RS02655	COG0251	oxidation-reduction process
H8Z71_RS02730	COG1063	alcohol dehydrogenase
H8Z71_RS02745	COG1132	(ABC) transporter
H8Z71_RS02765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8Z71_RS02770	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS02785	COG1294	oxidase, subunit
H8Z71_RS02790	COG1271	oxidase subunit
H8Z71_RS02835	COG3546	catalase activity
H8Z71_RS02840	COG3685	Protein conserved in bacteria
H8Z71_RS02855	COG2972	Histidine kinase
H8Z71_RS02870	COG0531	amino acid
H8Z71_RS02890	COG3590	peptidase
H8Z71_RS02900	COG0667	Aldo Keto reductase
H8Z71_RS02910	COG0583	DNA-binding transcription factor activity
H8Z71_RS02920	COG3384	dioxygenase
H8Z71_RS02930	COG1573	uracil-dna glycosylase
H8Z71_RS02935	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8Z71_RS02940	COG0025	NhaP-type Na H and K H
H8Z71_RS02945	COG1131	(ABC) transporter
H8Z71_RS02950	COG0842	Transport permease protein
H8Z71_RS03010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z71_RS03015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8Z71_RS03035	COG2205	protein histidine kinase activity
H8Z71_RS03035	COG2202	Pas domain
H8Z71_RS03055	COG2813	Specifically methylates the guanine in position
H8Z71_RS03060	COG1187	pseudouridine synthase activity
H8Z71_RS03065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z71_RS03085	COG5002	protein histidine kinase activity
H8Z71_RS03085	COG2198	Histidine kinase
H8Z71_RS03085	COG0784	Response regulator, receiver
H8Z71_RS03095	COG1666	GTP binding
H8Z71_RS03100	COG0697	spore germination
H8Z71_RS03105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8Z71_RS03150	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8Z71_RS03160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z71_RS03180	COG0356	it plays a direct role in the translocation of protons across the membrane
H8Z71_RS03190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8Z71_RS03195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8Z71_RS03200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8Z71_RS03205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8Z71_RS03210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8Z71_RS03215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8Z71_RS03230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8Z71_RS03235	COG4191	Histidine kinase
H8Z71_RS03250	COG0577	efflux transmembrane transporter activity
H8Z71_RS03255	COG0577	efflux transmembrane transporter activity
H8Z71_RS03260	COG1136	(ABC) transporter
H8Z71_RS03260	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z71_RS03265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z71_RS03270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z71_RS03325	COG0339	signal peptide processing
H8Z71_RS03340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z71_RS03345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z71_RS03360	COG2819	hydrolase of the alpha beta superfamily
H8Z71_RS03370	COG1956	GAF domain-containing protein
H8Z71_RS03375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8Z71_RS03385	COG0720	synthase
H8Z71_RS03390	COG4206	TonB-dependent receptor
H8Z71_RS03400	COG0513	Belongs to the DEAD box helicase family
H8Z71_RS03410	COG0625	glutathione transferase activity
H8Z71_RS03440	COG0626	cystathionine gamma-synthase activity
H8Z71_RS03455	COG0110	maltose O-acetyltransferase activity
H8Z71_RS03460	COG0438	transferase activity, transferring glycosyl groups
H8Z71_RS03460	COG1216	Glycosyl transferase, family 2
H8Z71_RS03465	COG3754	Rhamnan synthesis protein F
H8Z71_RS03475	COG2226	methyltransferase
H8Z71_RS03495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z71_RS03505	COG0300	oxidoreductase activity
H8Z71_RS03510	COG0277	FAD linked oxidase domain protein
H8Z71_RS03515	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z71_RS03515	COG0546	phosphoglycolate phosphatase activity
H8Z71_RS03530	COG2086	electron transfer activity
H8Z71_RS03560	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H8Z71_RS03560	COG0662	Cupin 2, conserved barrel domain protein
H8Z71_RS03565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z71_RS03600	COG3218	ABC-type transport auxiliary lipoprotein component
H8Z71_RS03600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z71_RS03605	COG1127	ABC transporter
H8Z71_RS03610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z71_RS03625	COG0442	prolyl-tRNA aminoacylation
H8Z71_RS03635	COG1183	phosphatidylcholine synthase activity
H8Z71_RS03665	COG0525	valine-tRNA ligase activity
H8Z71_RS03680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z71_RS03690	COG0795	lipopolysaccharide-transporting ATPase activity
H8Z71_RS03705	COG4974	Belongs to the 'phage' integrase family
H8Z71_RS03710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z71_RS03715	COG0047	phosphoribosylformylglycinamidine synthase activity
H8Z71_RS03715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8Z71_RS03720	COG5295	Hep Hag repeat protein
H8Z71_RS03725	COG1404	Belongs to the peptidase S8 family
H8Z71_RS03730	COG5295	Hep Hag repeat protein
H8Z71_RS03735	COG1404	Belongs to the peptidase S8 family
H8Z71_RS03740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z71_RS03745	COG1459	type II secretion system
H8Z71_RS03750	COG2165	general secretion pathway protein
H8Z71_RS03755	COG4970	Tfp pilus assembly protein FimT
H8Z71_RS03760	COG2165	general secretion pathway protein
H8Z71_RS03765	COG4795	General secretion pathway protein
H8Z71_RS03770	COG3156	type II secretion system protein K
H8Z71_RS03775	COG3166	PFAM Fimbrial assembly family protein
H8Z71_RS03790	COG1450	Type ii and iii secretion system protein
H8Z71_RS03805	COG2188	Transcriptional regulator
H8Z71_RS03850	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H8Z71_RS03865	COG1215	transferase activity, transferring glycosyl groups
H8Z71_RS03870	COG1215	transferase activity, transferring glycosyl groups
H8Z71_RS03875	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H8Z71_RS03880	COG0457	Tetratricopeptide repeat
H8Z71_RS03900	COG0242	peptide deformylase activity
H8Z71_RS03905	COG1307	EDD domain protein, DegV family
H8Z71_RS03940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z71_RS03945	COG0726	polysaccharide deacetylase
H8Z71_RS03950	COG4773	Receptor
H8Z71_RS03970	COG1162	GTPase activity
H8Z71_RS03995	COG2211	Major facilitator Superfamily
H8Z71_RS04000	COG1609	Transcriptional regulator
H8Z71_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS04010	COG2851	Citrate transporter
H8Z71_RS04025	COG0642	Histidine kinase
H8Z71_RS04035	COG2197	response regulator
H8Z71_RS04050	COG0667	Aldo Keto reductase
H8Z71_RS04055	COG0583	DNA-binding transcription factor activity
H8Z71_RS04080	COG1301	dicarboxylic acid transport
H8Z71_RS04085	COG0281	malic enzyme
H8Z71_RS04085	COG0280	phosphate acetyltransferase
H8Z71_RS04110	COG1560	Kdo2-lipid A biosynthetic process
H8Z71_RS04115	COG1519	Transferase
H8Z71_RS04120	COG1538	Outer membrane efflux protein
H8Z71_RS04125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z71_RS04145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8Z71_RS04150	COG0066	3-isopropylmalate dehydratase activity
H8Z71_RS04155	COG0473	3-isopropylmalate dehydrogenase activity
H8Z71_RS04160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8Z71_RS04180	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8Z71_RS04185	COG0405	Gamma-glutamyltransferase
H8Z71_RS04190	COG0840	transmembrane signaling receptor activity
H8Z71_RS04200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8Z71_RS04205	COG3710	Transcriptional regulator
H8Z71_RS04225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8Z71_RS04235	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H8Z71_RS04250	COG0563	adenylate kinase activity
H8Z71_RS04255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z71_RS04265	COG3781	membrane
H8Z71_RS04270	COG0671	phosphoesterase, PA-phosphatase related
H8Z71_RS04280	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS04290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z71_RS04295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8Z71_RS04325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z71_RS04340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z71_RS04355	COG0352	thiamine-phosphate diphosphorylase activity
H8Z71_RS04360	COG1773	rubredoxin
H8Z71_RS04365	COG2912	Transglutaminase-like superfamily
H8Z71_RS04375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8Z71_RS04385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8Z71_RS04405	COG3079	Belongs to the UPF0149 family
H8Z71_RS04410	COG0006	proline dipeptidase activity
H8Z71_RS04420	COG0006	proline dipeptidase activity
H8Z71_RS04435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8Z71_RS04440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8Z71_RS04450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8Z71_RS04455	COG1561	YicC-like family, N-terminal region
H8Z71_RS04460	COG0194	GDP metabolic process
H8Z71_RS04470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z71_RS04480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8Z71_RS04505	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8Z71_RS04535	COG0714	Associated with various cellular activities
H8Z71_RS04555	COG2304	oxidoreductase activity
H8Z71_RS04565	COG1301	dicarboxylic acid transport
H8Z71_RS04570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8Z71_RS04575	COG0596	Alpha beta hydrolase
H8Z71_RS04580	COG4773	Receptor
H8Z71_RS04595	COG0739	heme binding
H8Z71_RS04600	COG1376	ErfK ybiS ycfS ynhG family protein
H8Z71_RS04635	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H8Z71_RS04640	COG4149	molybdate abc transporter
H8Z71_RS04645	COG0725	ABC transporter, periplasmic molybdate-binding protein
H8Z71_RS04650	COG3453	Protein conserved in bacteria
H8Z71_RS04650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z71_RS04660	COG3047	cAMP biosynthetic process
H8Z71_RS04665	COG3047	cAMP biosynthetic process
H8Z71_RS04675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8Z71_RS04695	COG0126	phosphoglycerate kinase activity
H8Z71_RS04705	COG0469	pyruvate kinase activity
H8Z71_RS04710	COG3588	fructose-bisphosphate aldolase
H8Z71_RS04715	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8Z71_RS04730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z71_RS04730	COG1648	precorrin-2 dehydrogenase activity
H8Z71_RS04745	COG0784	Response regulator, receiver
H8Z71_RS04745	COG2198	Histidine kinase
H8Z71_RS04745	COG2205	protein histidine kinase activity
H8Z71_RS04765	COG0175	sulfate reduction
H8Z71_RS04770	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8Z71_RS04775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z71_RS04780	COG0175	sulfate reduction
H8Z71_RS04785	COG0529	Catalyzes the synthesis of activated sulfate
H8Z71_RS04785	COG2895	sulfate adenylyltransferase (ATP) activity
H8Z71_RS04795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z71_RS04830	COG0308	aminopeptidase N
H8Z71_RS04840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z71_RS04855	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z71_RS04860	COG3250	beta-galactosidase activity
H8Z71_RS04880	COG1970	mechanosensitive ion channel activity
H8Z71_RS04900	COG0471	metal ion transport
H8Z71_RS04900	COG3273	potassium ion transport
H8Z71_RS04905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8Z71_RS04910	COG2022	thiamine diphosphate biosynthetic process
H8Z71_RS04945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8Z71_RS05065	COG4191	Histidine kinase
H8Z71_RS05065	COG0784	Response regulator, receiver
H8Z71_RS05070	COG4191	Histidine kinase
H8Z71_RS05070	COG0784	Response regulator, receiver
H8Z71_RS05095	COG2003	Belongs to the UPF0758 family
H8Z71_RS05120	COG3039	Transposase
H8Z71_RS05180	COG0745	RESPONSE REGULATOR receiver
H8Z71_RS05185	COG5002	protein histidine kinase activity
H8Z71_RS05210	COG0237	dephospho-CoA kinase activity
H8Z71_RS05215	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8Z71_RS05245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z71_RS05260	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z71_RS05265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8Z71_RS05315	COG4644	lycopene metabolic process
H8Z71_RS05320	COG2951	lytic endotransglycosylase activity
H8Z71_RS05340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8Z71_RS05340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z71_RS05350	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z71_RS05355	COG0564	pseudouridine synthase activity
H8Z71_RS05370	COG3011	Protein conserved in bacteria
H8Z71_RS05375	COG0840	transmembrane signaling receptor activity
H8Z71_RS05390	COG3387	PFAM Glycoside hydrolase 15-related
H8Z71_RS05395	COG1877	trehalose-phosphatase activity
H8Z71_RS05435	COG2827	Endonuclease containing a URI domain
H8Z71_RS05440	COG4771	TonB-dependent receptor
H8Z71_RS05445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z71_RS05450	COG0667	Aldo Keto reductase
H8Z71_RS05455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8Z71_RS05460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z71_RS05465	COG1116	anion transmembrane transporter activity
H8Z71_RS05470	COG0542	response to heat
H8Z71_RS05475	COG4206	TonB-dependent receptor
H8Z71_RS05495	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z71_RS05505	COG1492	cobalamin metabolic process
H8Z71_RS05515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8Z71_RS05540	COG0019	diaminopimelate decarboxylase activity
H8Z71_RS05555	COG4264	IucA IucC family
H8Z71_RS05565	COG4772	TonB-dependent receptor
H8Z71_RS05590	COG4651	solute:proton antiporter activity
H8Z71_RS05590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z71_RS05620	COG0488	(ABC) transporter
H8Z71_RS05660	COG0477	Major facilitator Superfamily
H8Z71_RS05675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8Z71_RS05690	COG0217	transcriptional regulatory protein
H8Z71_RS05695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8Z71_RS05700	COG0632	four-way junction helicase activity
H8Z71_RS05705	COG3158	transport of potassium into the cell
H8Z71_RS05715	COG2255	four-way junction helicase activity
H8Z71_RS05720	COG0824	Thioesterase
H8Z71_RS05730	COG0848	biopolymer transport protein
H8Z71_RS05740	COG0823	Involved in the tonB-independent uptake of proteins
H8Z71_RS05745	COG2885	chlorophyll binding
H8Z71_RS05755	COG0602	queuosine metabolic process
H8Z71_RS05765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8Z71_RS05770	COG3920	Histidine kinase
H8Z71_RS05790	COG0840	transmembrane signaling receptor activity
H8Z71_RS05820	COG0514	ATP-dependent DNA helicase (RecQ)
H8Z71_RS05825	COG0783	Belongs to the Dps family
H8Z71_RS05830	COG1643	Atp-dependent helicase
H8Z71_RS05845	COG0837	glucose binding
H8Z71_RS05860	COG0535	radical SAM domain protein
H8Z71_RS05865	COG0535	radical SAM domain protein
H8Z71_RS05870	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H8Z71_RS05875	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H8Z71_RS05885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z71_RS05895	COG1215	transferase activity, transferring glycosyl groups
H8Z71_RS05900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z71_RS05910	COG1199	ATP-dependent helicase activity
H8Z71_RS05930	COG0189	ligase activity
H8Z71_RS05945	COG0835	chemotaxis
H8Z71_RS05950	COG0840	transmembrane signaling receptor activity
H8Z71_RS05955	COG2198	Histidine kinase
H8Z71_RS05955	COG0643	Histidine kinase
H8Z71_RS05955	COG0784	Response regulator, receiver
H8Z71_RS05975	COG1446	asparaginase
H8Z71_RS05980	COG3142	Participates in the control of copper homeostasis
H8Z71_RS06015	COG3537	Alpha-1,2-mannosidase
H8Z71_RS06025	COG1486	melibiose metabolic process
H8Z71_RS06035	COG0531	amino acid
H8Z71_RS06050	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z71_RS06060	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H8Z71_RS06065	COG3858	chitin binding
H8Z71_RS06065	COG1388	LysM domain
H8Z71_RS06080	COG0837	glucose binding
H8Z71_RS06085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8Z71_RS06095	COG0494	nUDIX hydrolase
H8Z71_RS06105	COG3956	TIGRFAM MazG family protein
H8Z71_RS06110	COG1742	UPF0060 membrane protein
H8Z71_RS06115	COG0330	HflC and HflK could
H8Z71_RS06125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8Z71_RS06130	COG0509	glycine decarboxylation via glycine cleavage system
H8Z71_RS06160	COG1960	acyl-CoA dehydrogenase activity
H8Z71_RS06170	COG1309	transcriptional regulator
H8Z71_RS06180	COG4771	TonB-dependent receptor
H8Z71_RS06190	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8Z71_RS06195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z71_RS06200	COG0463	Glycosyl transferase, family 2
H8Z71_RS06205	COG0517	IMP dehydrogenase activity
H8Z71_RS06205	COG0516	GMP reductase activity
H8Z71_RS06210	COG2982	Protein involved in outer membrane biogenesis
H8Z71_RS06215	COG1272	protein, Hemolysin III
H8Z71_RS06220	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8Z71_RS06225	COG0739	heme binding
H8Z71_RS06230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z71_RS06235	COG0626	cystathionine gamma-synthase activity
H8Z71_RS06240	COG0460	homoserine dehydrogenase
H8Z71_RS06240	COG0527	aspartate kinase activity
H8Z71_RS06250	COG1760	l-serine dehydratase
H8Z71_RS06270	COG2353	YceI-like domain
H8Z71_RS06275	COG2198	Histidine kinase
H8Z71_RS06275	COG0784	Response regulator, receiver
H8Z71_RS06275	COG2205	protein histidine kinase activity
H8Z71_RS06295	COG0477	Major facilitator Superfamily
H8Z71_RS06380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8Z71_RS06390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8Z71_RS06395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8Z71_RS06400	COG0259	pyridoxamine-phosphate oxidase activity
H8Z71_RS06410	COG1842	Phage shock protein A
H8Z71_RS06435	COG0754	glutathionylspermidine amidase activity
H8Z71_RS06445	COG2814	Major facilitator Superfamily
H8Z71_RS06480	COG1234	tRNA 3'-trailer cleavage
H8Z71_RS06500	COG0531	amino acid
H8Z71_RS06510	COG2197	response regulator
H8Z71_RS06530	COG1113	amino acid transport
H8Z71_RS06540	COG1271	oxidase subunit
H8Z71_RS06545	COG1294	oxidase, subunit
H8Z71_RS06560	COG2239	Acts as a magnesium transporter
H8Z71_RS06565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z71_RS06570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z71_RS06580	COG1660	Displays ATPase and GTPase activities
H8Z71_RS06585	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z71_RS06590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z71_RS06605	COG1137	ATPase activity
H8Z71_RS06610	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H8Z71_RS06620	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8Z71_RS06630	COG0271	Belongs to the BolA IbaG family
H8Z71_RS06635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8Z71_RS06655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8Z71_RS06665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8Z71_RS06675	COG0628	permease
H8Z71_RS06685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8Z71_RS06690	COG3178	'Phosphotransferase
H8Z71_RS06700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z71_RS06705	COG1555	photosystem II stabilization
H8Z71_RS06720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z71_RS06725	COG1477	protein flavinylation
H8Z71_RS06750	COG3128	pkhd-type hydroxylase
H8Z71_RS06755	COG4774	siderophore transport
H8Z71_RS06760	COG2146	nitrite reductase [NAD(P)H] activity
H8Z71_RS06770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8Z71_RS06775	COG0719	Fe-S assembly protein
H8Z71_RS06780	COG0396	ATPase activity
H8Z71_RS06785	COG0719	Fe-S assembly protein
H8Z71_RS06790	COG1959	2 iron, 2 sulfur cluster binding
H8Z71_RS06800	COG0693	protein deglycase activity
H8Z71_RS06820	COG0739	heme binding
H8Z71_RS06835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8Z71_RS06850	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z71_RS06865	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z71_RS06870	COG1678	Uncharacterized ACR, COG1678
H8Z71_RS06875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8Z71_RS06880	COG0540	Belongs to the ATCase OTCase family
H8Z71_RS06885	COG1764	response to oxidative stress
H8Z71_RS06895	COG0384	phenazine biosynthesis protein PhzF
H8Z71_RS06900	COG0384	phenazine biosynthesis protein PhzF
H8Z71_RS06905	COG0527	aspartate kinase activity
H8Z71_RS06920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8Z71_RS06930	COG0142	geranyltranstransferase activity
H8Z71_RS06935	COG0629	single-stranded DNA binding
H8Z71_RS06940	COG2203	Gaf domain
H8Z71_RS06940	COG3706	GGDEF domain
H8Z71_RS06940	COG4251	negative regulation of phosphorylation
H8Z71_RS06940	COG5001	Diguanylate cyclase
H8Z71_RS06960	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z71_RS06965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z71_RS06970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H8Z71_RS07005	COG2879	small protein
H8Z71_RS07010	COG1966	Carbon starvation protein
H8Z71_RS07015	COG1741	Belongs to the pirin family
H8Z71_RS07030	COG1741	Belongs to the pirin family
H8Z71_RS07040	COG1515	deoxyribonuclease V activity
H8Z71_RS07045	COG0588	phosphoglycerate mutase activity
H8Z71_RS07055	COG3590	peptidase
H8Z71_RS07060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z71_RS07065	COG2201	protein-glutamate methylesterase activity
H8Z71_RS07070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z71_RS07075	COG2199	diguanylate cyclase activity
H8Z71_RS07075	COG2202	Pas domain
H8Z71_RS07075	COG2200	EAL domain
H8Z71_RS07080	COG0835	chemotaxis
H8Z71_RS07085	COG0840	transmembrane signaling receptor activity
H8Z71_RS07090	COG0643	Histidine kinase
H8Z71_RS07090	COG2198	Histidine kinase
H8Z71_RS07120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8Z71_RS07130	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H8Z71_RS07135	COG0745	RESPONSE REGULATOR receiver
H8Z71_RS07140	COG2205	protein histidine kinase activity
H8Z71_RS07155	COG4452	Inner membrane protein CreD
H8Z71_RS07180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z71_RS07185	COG0735	belongs to the Fur family
H8Z71_RS07200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z71_RS07210	COG1309	transcriptional regulator
H8Z71_RS07220	COG2207	Transcriptional regulator
H8Z71_RS07230	COG0583	DNA-binding transcription factor activity
H8Z71_RS07235	COG2814	Major facilitator Superfamily
H8Z71_RS07240	COG0667	Aldo Keto reductase
H8Z71_RS07360	COG5001	Diguanylate cyclase
H8Z71_RS07360	COG5002	protein histidine kinase activity
H8Z71_RS07365	COG1187	pseudouridine synthase activity
H8Z71_RS07385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z71_RS07395	COG0475	glutathione-regulated potassium exporter activity
H8Z71_RS07400	COG5000	phosphorelay sensor kinase activity
H8Z71_RS07400	COG5002	protein histidine kinase activity
H8Z71_RS07405	COG0745	RESPONSE REGULATOR receiver
H8Z71_RS07410	COG1538	Outer membrane efflux protein
H8Z71_RS07440	COG1132	(ABC) transporter
H8Z71_RS07495	COG2155	Conserved Protein
H8Z71_RS07520	COG3118	belongs to the thioredoxin family
H8Z71_RS07530	COG0495	leucyl-tRNA aminoacylation
H8Z71_RS07545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8Z71_RS07560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8Z71_RS07575	COG2968	Membrane
H8Z71_RS07580	COG0424	maF-like protein
H8Z71_RS07590	COG3164	Protein of unknown function
H8Z71_RS07600	COG0312	modulator of DNA gyrase
H8Z71_RS07605	COG3028	Belongs to the UPF0307 family
H8Z71_RS07610	COG0312	modulator of DNA gyrase
H8Z71_RS07620	COG4104	PAAR repeat-containing protein
H8Z71_RS07625	COG0142	geranyltranstransferase activity
H8Z71_RS07630	COG1722	exodeoxyribonuclease VII activity
H8Z71_RS07635	COG0037	tRNA processing
H8Z71_RS07640	COG1785	Belongs to the alkaline phosphatase family
H8Z71_RS07645	COG1301	dicarboxylic acid transport
H8Z71_RS07650	COG4106	trans-aconitate 2-methyltransferase activity
H8Z71_RS07660	COG0791	NLP P60 protein
H8Z71_RS07665	COG0791	NLP P60 protein
H8Z71_RS07670	COG1047	Peptidyl-prolyl cis-trans
H8Z71_RS07675	COG2311	Membrane
H8Z71_RS07680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z71_RS07685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z71_RS07705	COG3590	peptidase
H8Z71_RS07710	COG3590	peptidase
H8Z71_RS07730	COG0489	protein tyrosine kinase activity
H8Z71_RS07735	COG0717	Belongs to the dCTP deaminase family
H8Z71_RS07765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z71_RS07780	COG0494	nUDIX hydrolase
H8Z71_RS07785	COG0433	COG0433 Predicted ATPase
H8Z71_RS07795	COG0688	phosphatidylethanolamine metabolic process
H8Z71_RS07805	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z71_RS07810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8Z71_RS07815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8Z71_RS07820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8Z71_RS07840	COG0101	tRNA pseudouridine synthase activity
H8Z71_RS07845	COG0135	phosphoribosylanthranilate isomerase activity
H8Z71_RS07855	COG0133	tryptophan synthase activity
H8Z71_RS07865	COG0159	tryptophan synthase activity
H8Z71_RS07870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8Z71_RS07875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z71_RS07905	COG0300	oxidoreductase activity
H8Z71_RS07910	COG0149	triose-phosphate isomerase activity
H8Z71_RS07925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z71_RS07930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z71_RS07935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z71_RS07940	COG0649	NAD binding
H8Z71_RS07945	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H8Z71_RS07950	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H8Z71_RS07960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8Z71_RS07965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z71_RS07990	COG1007	ATP synthesis coupled electron transport
H8Z71_RS08000	COG0779	Required for maturation of 30S ribosomal subunits
H8Z71_RS08005	COG0195	Participates in both transcription termination and antitermination
H8Z71_RS08010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8Z71_RS08015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8Z71_RS08020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8Z71_RS08025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8Z71_RS08030	COG1185	polyribonucleotide nucleotidyltransferase activity
H8Z71_RS08065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z71_RS08075	COG2095	MarC family integral membrane protein
H8Z71_RS08085	COG1611	Belongs to the LOG family
H8Z71_RS08090	COG3275	phosphorelay sensor kinase activity
H8Z71_RS08180	COG3179	chitinase
H8Z71_RS08225	COG4695	Portal protein
H8Z71_RS08315	COG0556	nucleotide-excision repair
H8Z71_RS08330	COG3505	Type IV secretory pathway VirD4
H8Z71_RS08350	COG2948	multi-organism process
H8Z71_RS08370	COG3702	type iv secretory pathway
H8Z71_RS08425	COG0366	Alpha amylase catalytic
H8Z71_RS08440	COG1082	Xylose isomerase domain protein TIM barrel
H8Z71_RS08465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8Z71_RS08470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8Z71_RS08485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8Z71_RS08490	COG0072	phenylalanine-tRNA ligase activity
H8Z71_RS08490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z71_RS08540	COG0438	transferase activity, transferring glycosyl groups
H8Z71_RS08545	COG0438	transferase activity, transferring glycosyl groups
H8Z71_RS08555	COG0438	transferase activity, transferring glycosyl groups
H8Z71_RS08580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z71_RS08585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z71_RS08590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z71_RS08610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8Z71_RS08620	COG1960	acyl-CoA dehydrogenase activity
H8Z71_RS08635	COG3040	lipid binding
H8Z71_RS08650	COG0322	excinuclease ABC activity
H8Z71_RS08665	COG0784	Response regulator, receiver
H8Z71_RS08665	COG4191	Histidine kinase
H8Z71_RS08670	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H8Z71_RS08675	COG1194	a g-specific adenine glycosylase
H8Z71_RS08680	COG0552	protein localization to endoplasmic reticulum
H8Z71_RS08690	COG3938	Belongs to the proline racemase family
H8Z71_RS08695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z71_RS08710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z71_RS08720	COG0006	proline dipeptidase activity
H8Z71_RS08735	COG0531	amino acid
H8Z71_RS08815	COG0326	Molecular chaperone. Has ATPase activity
H8Z71_RS08820	COG0742	ribosomal rna small subunit methyltransferase
H8Z71_RS08825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8Z71_RS08835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8Z71_RS08840	COG0405	Gamma-glutamyltransferase
H8Z71_RS08845	COG3291	Pkd domain containing protein
H8Z71_RS08850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8Z71_RS08885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8Z71_RS08890	COG0343	queuine tRNA-ribosyltransferase activity
H8Z71_RS08895	COG1862	Preprotein translocase
H8Z71_RS08905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8Z71_RS08950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z71_RS08950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z71_RS08955	COG1105	Belongs to the carbohydrate kinase PfkB family
H8Z71_RS08960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z71_RS08960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z71_RS08965	COG1609	Transcriptional regulator
H8Z71_RS08970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z71_RS08975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z71_RS08985	COG2902	Dehydrogenase
H8Z71_RS08995	COG0477	Major facilitator Superfamily
H8Z71_RS09005	COG5002	protein histidine kinase activity
H8Z71_RS09005	COG2205	protein histidine kinase activity
H8Z71_RS09005	COG0784	Response regulator, receiver
H8Z71_RS09010	COG2733	membrane
H8Z71_RS09020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8Z71_RS09025	COG2223	nitrite transmembrane transporter activity
H8Z71_RS09030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H8Z71_RS09035	COG0243	molybdopterin cofactor binding
H8Z71_RS09045	COG0477	Major facilitator Superfamily
H8Z71_RS09050	COG2703	oxygen carrier activity
H8Z71_RS09060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z71_RS09065	COG0174	glutamine synthetase
H8Z71_RS09070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H8Z71_RS09085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H8Z71_RS09105	COG3842	ATPase activity
H8Z71_RS09110	COG1176	ABC-type spermidine putrescine transport system, permease component I
H8Z71_RS09115	COG1177	transmembrane transport
H8Z71_RS09120	COG1012	belongs to the aldehyde dehydrogenase family
H8Z71_RS09135	COG4535	Mg2 and Co2 transporter CorC
H8Z71_RS09145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8Z71_RS09155	COG1702	phosphate starvation-inducible protein PhoH
H8Z71_RS09160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z71_RS09175	COG0741	lytic transglycosylase activity
H8Z71_RS09180	COG0723	plastoquinol--plastocyanin reductase activity
H8Z71_RS09185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8Z71_RS09190	COG2857	Cytochrome c1
H8Z71_RS09195	COG0625	glutathione transferase activity
H8Z71_RS09200	COG2969	positive regulation of protein catabolic process
H8Z71_RS09220	COG1201	RNA secondary structure unwinding
H8Z71_RS09225	COG2094	Belongs to the DNA glycosylase MPG family
H8Z71_RS09230	COG0840	transmembrane signaling receptor activity
H8Z71_RS09235	COG0835	chemotaxis
H8Z71_RS09315	COG2226	methyltransferase
H8Z71_RS09315	COG1073	alpha beta
H8Z71_RS09325	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS09340	COG1238	metal cluster binding
H8Z71_RS09375	COG3279	Response regulator of the LytR AlgR family
H8Z71_RS09415	COG4566	intracellular signal transduction
H8Z71_RS09425	COG5001	Diguanylate cyclase
H8Z71_RS09445	COG3685	Protein conserved in bacteria
H8Z71_RS09470	COG1648	precorrin-2 dehydrogenase activity
H8Z71_RS09470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z71_RS09485	COG2814	Major facilitator Superfamily
H8Z71_RS09500	COG1335	isochorismatase
H8Z71_RS09520	COG2197	response regulator
H8Z71_RS09540	COG0583	DNA-binding transcription factor activity
H8Z71_RS09545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z71_RS09550	COG3002	Belongs to the UPF0753 family
H8Z71_RS09565	COG1396	sequence-specific DNA binding
H8Z71_RS09570	COG5489	Protein of unknown function (DUF736)
H8Z71_RS09580	COG2003	Belongs to the UPF0758 family
H8Z71_RS09610	COG0582	viral genome integration into host DNA
H8Z71_RS09615	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z71_RS09615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z71_RS09625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8Z71_RS09635	COG0475	glutathione-regulated potassium exporter activity
H8Z71_RS09635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z71_RS09640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8Z71_RS09650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z71_RS09655	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H8Z71_RS09665	COG0776	regulation of translation
H8Z71_RS09670	COG0539	negative regulation of cytoplasmic translation
H8Z71_RS09675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8Z71_RS09690	COG2957	Belongs to the agmatine deiminase family
H8Z71_RS09695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z71_RS09720	COG0395	ABC-type sugar transport system, permease component
H8Z71_RS09725	COG1175	transmembrane transport
H8Z71_RS09755	COG2350	Protein conserved in bacteria
H8Z71_RS09760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H8Z71_RS09765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H8Z71_RS09770	COG1187	pseudouridine synthase activity
H8Z71_RS09790	COG0436	Aminotransferase
H8Z71_RS09795	COG4133	protoheme IX ABC transporter activity
H8Z71_RS09815	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z71_RS09820	COG1138	Cytochrome C-type biogenesis protein
H8Z71_RS09840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z71_RS09845	COG1278	Cold shock
H8Z71_RS09850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8Z71_RS09855	COG4988	ABC transporter
H8Z71_RS09900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8Z71_RS09905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8Z71_RS09915	COG0165	Argininosuccinate lyase
H8Z71_RS09920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8Z71_RS09930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8Z71_RS09935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z71_RS09945	COG0137	argininosuccinate synthase activity
H8Z71_RS09950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8Z71_RS09960	COG0215	cysteine-tRNA ligase activity
H8Z71_RS09965	COG2166	iron-sulfur cluster assembly
H8Z71_RS09980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8Z71_RS09985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8Z71_RS10015	COG4302	ethanolamine ammonia-lyase activity
H8Z71_RS10070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8Z71_RS10075	COG0402	S-adenosylhomocysteine deaminase activity
H8Z71_RS10085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z71_RS10090	COG1509	lysine 2,3-aminomutase activity
H8Z71_RS10095	COG5001	Diguanylate cyclase
H8Z71_RS10095	COG3300	MHYT domain
H8Z71_RS10110	COG0483	inositol monophosphate 1-phosphatase activity
H8Z71_RS10115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8Z71_RS10130	COG0488	(ABC) transporter
H8Z71_RS10135	COG0513	Belongs to the DEAD box helicase family
H8Z71_RS10140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8Z71_RS10145	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H8Z71_RS10160	COG0625	glutathione transferase activity
H8Z71_RS10170	COG4681	YaeQ
H8Z71_RS10175	COG2081	HI0933 family
H8Z71_RS10185	COG0501	Belongs to the peptidase M48B family
H8Z71_RS10190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z71_RS10195	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS10220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H8Z71_RS10225	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z71_RS10230	COG0802	atpase or kinase
H8Z71_RS10235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z71_RS10235	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8Z71_RS10240	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z71_RS10245	COG1570	exodeoxyribonuclease VII activity
H8Z71_RS10255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z71_RS10410	COG0316	Belongs to the HesB IscA family
H8Z71_RS10410	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8Z71_RS10415	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8Z71_RS10425	COG0428	transporter
H8Z71_RS10430	COG3064	Membrane
H8Z71_RS10440	COG1530	ribonuclease E activity
H8Z71_RS10450	COG1054	Belongs to the UPF0176 family
H8Z71_RS10470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H8Z71_RS10480	COG0582	viral genome integration into host DNA
H8Z71_RS10495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z71_RS10500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z71_RS10585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8Z71_RS10650	COG0629	single-stranded DNA binding
H8Z71_RS10655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z71_RS10660	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z71_RS10835	COG2003	Belongs to the UPF0758 family
H8Z71_RS10940	COG0583	DNA-binding transcription factor activity
H8Z71_RS10945	COG1396	sequence-specific DNA binding
H8Z71_RS10955	COG0582	viral genome integration into host DNA
H8Z71_RS10965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z71_RS10970	COG0322	excinuclease ABC activity
H8Z71_RS10980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8Z71_RS10985	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H8Z71_RS10990	COG1663	tetraacyldisaccharide 4'-kinase activity
H8Z71_RS10995	COG1132	(ABC) transporter
H8Z71_RS11005	COG0811	peptide transport
H8Z71_RS11020	COG1136	(ABC) transporter
H8Z71_RS11025	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z71_RS11035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H8Z71_RS11040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8Z71_RS11055	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H8Z71_RS11080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z71_RS11085	COG0837	glucose binding
H8Z71_RS11090	COG0363	glucosamine-6-phosphate deaminase activity
H8Z71_RS11095	COG0129	dihydroxy-acid dehydratase activity
H8Z71_RS11100	COG0800	Aldolase
H8Z71_RS11175	COG0784	Response regulator, receiver
H8Z71_RS11175	COG2205	protein histidine kinase activity
H8Z71_RS11180	COG2183	response to ionizing radiation
H8Z71_RS11190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z71_RS11190	COG0723	plastoquinol--plastocyanin reductase activity
H8Z71_RS11205	COG3243	poly(R)-hydroxyalkanoic acid synthase
H8Z71_RS11215	COG1183	phosphatidylcholine synthase activity
H8Z71_RS11220	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS11235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H8Z71_RS11245	COG0668	transmembrane transport
H8Z71_RS11250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H8Z71_RS11265	COG1914	H( )-stimulated, divalent metal cation uptake system
H8Z71_RS11280	COG0746	molybdenum cofactor guanylyltransferase activity
H8Z71_RS11285	COG0303	'Molybdopterin
H8Z71_RS11295	COG0708	Exodeoxyribonuclease III
H8Z71_RS11330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8Z71_RS11335	COG0303	'Molybdopterin
H8Z71_RS11340	COG1160	GTP binding
H8Z71_RS11345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z71_RS11355	COG1426	Protein conserved in bacteria
H8Z71_RS11365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8Z71_RS11380	COG1024	Enoyl-CoA hydratase
H8Z71_RS11380	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z71_RS11385	COG0183	Belongs to the thiolase family
H8Z71_RS11390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8Z71_RS11395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H8Z71_RS11405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H8Z71_RS11415	COG1674	ftsk spoiiie
H8Z71_RS11420	COG0492	ferredoxin-NADP+ reductase activity
H8Z71_RS11430	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H8Z71_RS11440	COG0542	response to heat
H8Z71_RS11455	COG0482	sulfurtransferase activity
H8Z71_RS11460	COG2915	High frequency lysogenization protein hflD homolog
H8Z71_RS11490	COG5002	protein histidine kinase activity
H8Z71_RS11510	COG0835	chemotaxis
H8Z71_RS11510	COG0784	Response regulator, receiver
H8Z71_RS11520	COG1558	bacterial-type flagellum-dependent cell motility
H8Z71_RS11525	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H8Z71_RS11535	COG4787	bacterial-type flagellum-dependent cell motility
H8Z71_RS11545	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H8Z71_RS11550	COG1706	bacterial-type flagellum-dependent cell motility
H8Z71_RS11555	COG3951	Flagellar rod assembly protein muramidase FlgJ
H8Z71_RS11555	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8Z71_RS11565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z71_RS11570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z71_RS11580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H8Z71_RS11610	COG2201	protein-glutamate methylesterase activity
H8Z71_RS11630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z71_RS11635	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS11640	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS11670	COG1677	Flagellar hook-basal body complex protein FliE
H8Z71_RS11720	COG3190	flagellar
H8Z71_RS11735	COG1684	flagellar biosynthetic protein fliR
H8Z71_RS11760	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z71_RS11790	COG0643	Histidine kinase
H8Z71_RS11790	COG0784	Response regulator, receiver
H8Z71_RS11790	COG2198	Histidine kinase
H8Z71_RS11800	COG0641	radical SAM
H8Z71_RS11885	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8Z71_RS11890	COG1360	Flagellar Motor Protein
H8Z71_RS11900	COG0835	chemotaxis
H8Z71_RS11910	COG0745	RESPONSE REGULATOR receiver
H8Z71_RS11915	COG2198	Histidine kinase
H8Z71_RS11915	COG0643	Histidine kinase
H8Z71_RS11920	COG0840	transmembrane signaling receptor activity
H8Z71_RS11935	COG0840	transmembrane signaling receptor activity
H8Z71_RS11945	COG0840	transmembrane signaling receptor activity
H8Z71_RS11950	COG0840	transmembrane signaling receptor activity
H8Z71_RS11955	COG0840	transmembrane signaling receptor activity
H8Z71_RS11960	COG0840	transmembrane signaling receptor activity
H8Z71_RS11965	COG0840	transmembrane signaling receptor activity
H8Z71_RS11970	COG0840	transmembrane signaling receptor activity
H8Z71_RS11975	COG0840	transmembrane signaling receptor activity
H8Z71_RS11980	COG0840	transmembrane signaling receptor activity
H8Z71_RS11985	COG0840	transmembrane signaling receptor activity
H8Z71_RS11995	COG0835	chemotaxis
H8Z71_RS12005	COG0840	transmembrane signaling receptor activity
H8Z71_RS12015	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H8Z71_RS12020	COG2201	protein-glutamate methylesterase activity
H8Z71_RS12030	COG2267	carboxylic ester hydrolase activity
H8Z71_RS12065	COG1024	Enoyl-CoA hydratase
H8Z71_RS12070	COG0784	Response regulator, receiver
H8Z71_RS12070	COG2198	Histidine kinase
H8Z71_RS12070	COG2205	protein histidine kinase activity
H8Z71_RS12080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8Z71_RS12090	COG3279	Response regulator of the LytR AlgR family
H8Z71_RS12130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8Z71_RS12140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z71_RS12145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8Z71_RS12155	COG0505	Belongs to the CarA family
H8Z71_RS12160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8Z71_RS12165	COG2258	MOSC domain
H8Z71_RS12170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z71_RS12215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z71_RS12235	COG0277	FAD linked oxidase domain protein
H8Z71_RS12240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8Z71_RS12250	COG0531	amino acid
H8Z71_RS12255	COG0531	amino acid
H8Z71_RS12260	COG0235	Class ii aldolase
H8Z71_RS12265	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8Z71_RS12270	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8Z71_RS12285	COG0140	phosphoribosyl-ATP diphosphatase activity
H8Z71_RS12285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8Z71_RS12290	COG0107	imidazoleglycerol-phosphate synthase activity
H8Z71_RS12295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8Z71_RS12300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8Z71_RS12305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8Z71_RS12305	COG0131	Imidazoleglycerol-phosphate dehydratase
H8Z71_RS12310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z71_RS12315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8Z71_RS12320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8Z71_RS12330	COG0124	histidyl-tRNA synthetase
H8Z71_RS12335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z71_RS12385	COG3210	domain, Protein
H8Z71_RS12395	COG3210	domain, Protein
H8Z71_RS12410	COG1649	PFAM Uncharacterised BCR, COG1649
H8Z71_RS12410	COG0726	polysaccharide deacetylase
H8Z71_RS12415	COG1215	transferase activity, transferring glycosyl groups
H8Z71_RS12430	COG1012	belongs to the aldehyde dehydrogenase family
H8Z71_RS12445	COG0167	dihydroorotate dehydrogenase activity
H8Z71_RS12450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8Z71_RS12455	COG0697	spore germination
H8Z71_RS12460	COG1794	racemase activity, acting on amino acids and derivatives
H8Z71_RS12475	COG0671	phosphoesterase, PA-phosphatase related
H8Z71_RS12480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8Z71_RS12490	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H8Z71_RS12495	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z71_RS12505	COG2203	Gaf domain
H8Z71_RS12505	COG5001	Diguanylate cyclase
H8Z71_RS12505	COG4251	negative regulation of phosphorylation
H8Z71_RS12505	COG3706	GGDEF domain
H8Z71_RS12515	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z71_RS12535	COG0166	Belongs to the GPI family
H8Z71_RS12540	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H8Z71_RS12545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8Z71_RS12550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8Z71_RS12570	COG1469	GTP cyclohydrolase I activity
H8Z71_RS12575	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z71_RS12595	COG0477	Major facilitator Superfamily
H8Z71_RS12600	COG2115	Belongs to the xylose isomerase family
H8Z71_RS12605	COG1070	Carbohydrate kinase
H8Z71_RS12615	COG1501	Belongs to the glycosyl hydrolase 31 family
H8Z71_RS12650	COG0800	Aldolase
H8Z71_RS12655	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z71_RS12665	COG3734	2-keto-3-deoxy-galactonokinase
H8Z71_RS12670	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8Z71_RS12680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z71_RS12695	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8Z71_RS12700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8Z71_RS12715	COG0352	thiamine-phosphate diphosphorylase activity
H8Z71_RS12715	COG0351	phosphomethylpyrimidine kinase
H8Z71_RS12740	COG0583	DNA-binding transcription factor activity
H8Z71_RS12745	COG1741	Belongs to the pirin family
H8Z71_RS12760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8Z71_RS12765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8Z71_RS12770	COG2137	regulation of response to DNA damage stimulus
H8Z71_RS12775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8Z71_RS12780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z71_RS12790	COG1546	Belongs to the CinA family
H8Z71_RS12795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8Z71_RS12805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8Z71_RS12810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8Z71_RS12820	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H8Z71_RS12825	COG1534	Rna-binding protein
H8Z71_RS12840	COG1238	metal cluster binding
H8Z71_RS12845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z71_RS12850	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8Z71_RS12855	COG2840	Smr protein MutS2
H8Z71_RS12860	COG0585	pseudouridine synthase activity
H8Z71_RS12865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8Z71_RS12870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8Z71_RS12875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H8Z71_RS12880	COG0148	phosphopyruvate hydratase activity
H8Z71_RS12890	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8Z71_RS12895	COG0504	CTP synthase activity
H8Z71_RS12920	COG0306	phosphate transporter
H8Z71_RS12930	COG1253	flavin adenine dinucleotide binding
H8Z71_RS12945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z71_RS12950	COG0477	Major facilitator Superfamily
H8Z71_RS12960	COG1136	(ABC) transporter
H8Z71_RS12975	COG0438	transferase activity, transferring glycosyl groups
H8Z71_RS12985	COG2264	protein methyltransferase activity
H8Z71_RS13015	COG2244	polysaccharide biosynthetic process
H8Z71_RS13065	COG1595	DNA-templated transcription, initiation
H8Z71_RS13080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z71_RS13090	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z71_RS13100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z71_RS13115	COG4191	Histidine kinase
H8Z71_RS13115	COG0784	Response regulator, receiver
H8Z71_RS13120	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8Z71_RS13145	COG0840	transmembrane signaling receptor activity
H8Z71_RS13210	COG0583	DNA-binding transcription factor activity
H8Z71_RS13215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z71_RS13220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8Z71_RS13235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8Z71_RS13240	COG0077	Prephenate dehydratase
H8Z71_RS13240	COG1605	Chorismate mutase
H8Z71_RS13245	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H8Z71_RS13250	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8Z71_RS13255	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H8Z71_RS13300	COG1228	amidohydrolase
H8Z71_RS13305	COG2986	histidine ammonia-lyase
H8Z71_RS13315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H8Z71_RS13325	COG4993	Dehydrogenase
H8Z71_RS13335	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8Z71_RS13350	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H8Z71_RS13355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8Z71_RS13360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z71_RS13370	COG3115	cell septum assembly
H8Z71_RS13380	COG0359	binds to the 23S rRNA
H8Z71_RS13385	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8Z71_RS13390	COG0360	Binds together with S18 to 16S ribosomal RNA
H8Z71_RS13395	COG0316	Belongs to the HesB IscA family
H8Z71_RS13400	COG0017	Asparaginyl-tRNA synthetase
H8Z71_RS13420	COG2808	Putative FMN-binding domain
H8Z71_RS13485	COG0288	reversible hydration of carbon dioxide
H8Z71_RS13490	COG0662	Cupin 2, conserved barrel domain protein
H8Z71_RS13500	COG3844	kynureninase activity
H8Z71_RS13505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z71_RS13515	COG2925	Exonuclease
H8Z71_RS13540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8Z71_RS13545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z71_RS13545	COG0116	Belongs to the methyltransferase superfamily
H8Z71_RS13555	COG0488	(ABC) transporter
H8Z71_RS13590	COG0494	nUDIX hydrolase
H8Z71_RS13600	COG1024	Enoyl-CoA hydratase
H8Z71_RS13610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8Z71_RS13615	COG0659	secondary active sulfate transmembrane transporter activity
H8Z71_RS13640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8Z71_RS13645	COG0573	inorganic phosphate transmembrane transporter activity
H8Z71_RS13650	COG0581	inorganic phosphate transmembrane transporter activity
H8Z71_RS13655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8Z71_RS13660	COG0704	Plays a role in the regulation of phosphate uptake
H8Z71_RS13670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z71_RS13680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z71_RS13690	COG0557	exoribonuclease II activity
H8Z71_RS13705	COG1960	acyl-CoA dehydrogenase activity
H8Z71_RS13710	COG1960	acyl-CoA dehydrogenase activity
H8Z71_RS13715	COG1960	acyl-CoA dehydrogenase activity
H8Z71_RS13720	COG1960	acyl-CoA dehydrogenase activity
H8Z71_RS13725	COG2226	methyltransferase
H8Z71_RS13730	COG0646	methionine synthase
H8Z71_RS13730	COG1410	methionine synthase
H8Z71_RS13735	COG0646	methionine synthase
H8Z71_RS13735	COG1410	methionine synthase
H8Z71_RS13745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z71_RS13770	COG2900	Belongs to the SlyX family
H8Z71_RS13785	COG0386	Belongs to the glutathione peroxidase family
H8Z71_RS13795	COG1725	Transcriptional regulator
H8Z71_RS13800	COG1131	(ABC) transporter
H8Z71_RS13830	COG1253	flavin adenine dinucleotide binding
H8Z71_RS13850	COG2850	peptidyl-arginine hydroxylation
H8Z71_RS13885	COG1132	(ABC) transporter
H8Z71_RS13890	COG0583	DNA-binding transcription factor activity
H8Z71_RS13920	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H8Z71_RS13930	COG0484	heat shock protein binding
H8Z71_RS13935	COG0443	Heat shock 70 kDa protein
H8Z71_RS13940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8Z71_RS13945	COG1420	regulation of RNA biosynthetic process
H8Z71_RS13950	COG0497	DNA recombination
H8Z71_RS13960	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z71_RS13975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8Z71_RS14000	COG3706	GGDEF domain
H8Z71_RS14045	COG0583	DNA-binding transcription factor activity
H8Z71_RS14055	COG0415	Belongs to the DNA photolyase family
H8Z71_RS14060	COG0305	Participates in initiation and elongation during chromosome replication
H8Z71_RS14070	COG0367	asparagine synthase
H8Z71_RS14085	COG1960	acyl-CoA dehydrogenase activity
H8Z71_RS14100	COG0084	hydrolase, TatD family'
H8Z71_RS14105	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8Z71_RS14160	COG0386	Belongs to the glutathione peroxidase family
H8Z71_RS14165	COG0339	signal peptide processing
H8Z71_RS14215	COG2814	Major facilitator Superfamily
H8Z71_RS14220	COG1566	PFAM secretion protein HlyD family protein
H8Z71_RS14250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z71_RS14265	COG4774	siderophore transport
H8Z71_RS14275	COG0367	asparagine synthase
H8Z71_RS14280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z71_RS14285	COG1393	Belongs to the ArsC family
H8Z71_RS14295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H8Z71_RS14335	COG0052	Belongs to the universal ribosomal protein uS2 family
H8Z71_RS14340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8Z71_RS14350	COG0528	UMP kinase activity
H8Z71_RS14355	COG0233	cytoplasmic translational termination
H8Z71_RS14360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8Z71_RS14365	COG0575	Belongs to the CDS family
H8Z71_RS14370	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8Z71_RS14375	COG0750	zinc metalloprotease
H8Z71_RS14390	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z71_RS14395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z71_RS14400	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z71_RS14405	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z71_RS14410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8Z71_RS14420	COG0825	malonyl-CoA metabolic process
H8Z71_RS14435	COG1981	membrane
H8Z71_RS14455	COG1695	Transcriptional regulator
H8Z71_RS14475	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z71_RS14485	COG2040	homocysteine
H8Z71_RS14490	COG0833	amino acid
H8Z71_RS14495	COG0346	lactoylglutathione lyase activity
H8Z71_RS14500	COG1131	(ABC) transporter
H8Z71_RS14515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z71_RS14515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z71_RS14525	COG2878	Part of a membrane complex involved in electron transport
H8Z71_RS14540	COG1595	DNA-templated transcription, initiation
H8Z71_RS14565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z71_RS14580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z71_RS14585	COG0251	oxidation-reduction process
H8Z71_RS14595	COG0392	lysyltransferase activity
H8Z71_RS14595	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H8Z71_RS14630	COG2814	Major facilitator Superfamily
H8Z71_RS14635	COG1902	pentaerythritol trinitrate reductase activity
H8Z71_RS14640	COG2824	Alkylphosphonate utilization operon protein PhnA
H8Z71_RS14650	COG1047	Peptidyl-prolyl cis-trans
H8Z71_RS14655	COG1077	Cell shape determining protein MreB Mrl
H8Z71_RS14670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8Z71_RS14680	COG5487	UPF0391 membrane protein
H8Z71_RS14685	COG1451	nucleotide metabolic process
H8Z71_RS14710	COG0183	Belongs to the thiolase family
H8Z71_RS14740	COG1793	dna ligase
H8Z71_RS14740	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z71_RS14750	COG1793	dna ligase
H8Z71_RS14755	COG1201	RNA secondary structure unwinding
H8Z71_RS14765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z71_RS14770	COG1278	Cold shock
H8Z71_RS14775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8Z71_RS14780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H8Z71_RS14785	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z71_RS14790	COG3046	protein related to deoxyribodipyrimidine photolyase
H8Z71_RS14795	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H8Z71_RS14800	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H8Z71_RS14805	COG2954	triphosphatase activity
H8Z71_RS14810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z71_RS14820	COG1381	Involved in DNA repair and RecF pathway recombination
H8Z71_RS14825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8Z71_RS14830	COG0571	ribonuclease III activity
H8Z71_RS14845	COG0481	GTPase activity
H8Z71_RS14850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z71_RS14865	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z71_RS14865	COG1024	Enoyl-CoA hydratase
H8Z71_RS14885	COG1024	Enoyl-CoA hydratase
H8Z71_RS14890	COG1960	acyl-CoA dehydrogenase activity
H8Z71_RS14910	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H8Z71_RS14915	COG3250	beta-galactosidase activity
H8Z71_RS14935	COG3209	COG3209 Rhs family protein
H8Z71_RS14945	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8Z71_RS14955	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H8Z71_RS14975	COG0534	Mate efflux family protein
H8Z71_RS14980	COG0335	large ribosomal subunit rRNA binding
H8Z71_RS14985	COG0336	Belongs to the RNA methyltransferase TrmD family
H8Z71_RS14990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8Z71_RS14995	COG0228	four-way junction DNA binding
H8Z71_RS15000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z71_RS15010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8Z71_RS15015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z71_RS15045	COG0784	Response regulator, receiver
H8Z71_RS15045	COG4191	Histidine kinase
H8Z71_RS15050	COG3437	response regulator, receiver
H8Z71_RS15050	COG2205	protein histidine kinase activity
H8Z71_RS15050	COG3850	Histidine kinase
H8Z71_RS15050	COG4999	Histidine kinase
H8Z71_RS15055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z71_RS15065	COG2205	protein histidine kinase activity
H8Z71_RS15070	COG5507	3-demethylubiquinone-9 3-methyltransferase
H8Z71_RS15080	COG4771	TonB-dependent receptor
H8Z71_RS15105	COG2172	sigma factor antagonist activity
H8Z71_RS15110	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z71_RS15115	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z71_RS15125	COG0326	Molecular chaperone. Has ATPase activity
H8Z71_RS15130	COG2207	Transcriptional regulator
H8Z71_RS15140	COG3152	Membrane
H8Z71_RS15155	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8Z71_RS15160	COG1845	cytochrome c oxidase, subunit III
H8Z71_RS15165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8Z71_RS15180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8Z71_RS15185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8Z71_RS15190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8Z71_RS15195	COG0196	riboflavin kinase activity
H8Z71_RS15205	COG0268	Binds directly to 16S ribosomal RNA
H8Z71_RS15210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8Z71_RS15215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8Z71_RS15220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8Z71_RS15225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8Z71_RS15230	COG0824	Thioesterase
H8Z71_RS15245	COG1946	Acyl-CoA thioesterase
H8Z71_RS15265	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H8Z71_RS15275	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8Z71_RS15300	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8Z71_RS15315	COG2197	response regulator
H8Z71_RS15320	COG4585	Histidine kinase
H8Z71_RS15330	COG0850	regulation of cytokinetic process
H8Z71_RS15335	COG2894	cell division
H8Z71_RS15340	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8Z71_RS15350	COG0642	Histidine kinase
H8Z71_RS15355	COG0745	RESPONSE REGULATOR receiver
H8Z71_RS15370	COG2194	sulfuric ester hydrolase activity
H8Z71_RS15385	COG2814	Major facilitator Superfamily
H8Z71_RS15390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z71_RS15390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z71_RS15400	COG0656	L-ascorbic acid biosynthetic process
H8Z71_RS15405	COG0753	catalase activity
H8Z71_RS15420	COG2207	Transcriptional regulator
H8Z71_RS15420	COG1917	Cupin 2, conserved barrel domain protein
H8Z71_RS15435	COG0823	Involved in the tonB-independent uptake of proteins
H8Z71_RS15435	COG1506	peptidase
H8Z71_RS15450	COG1297	OPT oligopeptide transporter protein
H8Z71_RS15470	COG0587	DNA-directed DNA polymerase activity
H8Z71_RS15485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z71_RS15520	COG2080	2 iron, 2 sulfur cluster binding
H8Z71_RS15525	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z71_RS15530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z71_RS15555	COG0492	ferredoxin-NADP+ reductase activity
H8Z71_RS15575	COG3537	Alpha-1,2-mannosidase
H8Z71_RS15580	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS15585	COG3387	PFAM Glycoside hydrolase 15-related
H8Z71_RS15595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z71_RS15625	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H8Z71_RS15670	COG1309	transcriptional regulator
H8Z71_RS15675	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS15680	COG0308	aminopeptidase N
H8Z71_RS15685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8Z71_RS15695	COG0330	HflC and HflK could
H8Z71_RS15700	COG0330	HflC and HflK could
H8Z71_RS15720	COG0678	peroxiredoxin activity
H8Z71_RS15730	COG4953	penicillin-binding protein 1C
H8Z71_RS15745	COG2373	Large extracellular alpha-helical protein
H8Z71_RS15775	COG3609	addiction module antidote protein, CC2985 family
H8Z71_RS15795	COG3829	transcription factor binding
H8Z71_RS15820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8Z71_RS15825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8Z71_RS15840	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS15855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z71_RS15860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8Z71_RS15865	COG1399	metal-binding, possibly nucleic acid-binding protein
H8Z71_RS15870	COG0424	maF-like protein
H8Z71_RS15890	COG0714	Associated with various cellular activities
H8Z71_RS15910	COG0537	adenosine 5'-monophosphoramidase activity
H8Z71_RS15915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8Z71_RS15920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8Z71_RS15965	COG0210	DNA helicase
H8Z71_RS16035	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H8Z71_RS16055	COG2003	Belongs to the UPF0758 family
H8Z71_RS16135	COG0314	molybdopterin synthase activity
H8Z71_RS16140	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8Z71_RS16145	COG0315	cyclic pyranopterin monophosphate synthase activity
H8Z71_RS16155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8Z71_RS16160	COG1234	tRNA 3'-trailer cleavage
H8Z71_RS16165	COG3642	lipopolysaccharide core region biosynthetic process
H8Z71_RS16170	COG0859	PFAM glycosyl transferase family 9
H8Z71_RS16185	COG0631	protein serine/threonine phosphatase activity
H8Z71_RS16190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z71_RS16195	COG0328	RNA-DNA hybrid ribonuclease activity
H8Z71_RS16205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z71_RS16215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z71_RS16245	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8Z71_RS16255	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8Z71_RS16410	COG0473	3-isopropylmalate dehydrogenase activity
H8Z71_RS16425	COG4783	chaperone-mediated protein folding
H8Z71_RS16440	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8Z71_RS16450	COG0438	transferase activity, transferring glycosyl groups
H8Z71_RS16455	COG0671	phosphoesterase, PA-phosphatase related
H8Z71_RS16460	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z71_RS16470	COG3291	Pkd domain containing protein
H8Z71_RS16480	COG2833	Protein of unknown function (DUF455)
H8Z71_RS16500	COG0285	dihydrofolate synthase activity
H8Z71_RS16505	COG0406	alpha-ribazole phosphatase activity
H8Z71_RS16535	COG1063	alcohol dehydrogenase
H8Z71_RS16545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H8Z71_RS16550	COG4208	sulfate ABC transporter
H8Z71_RS16555	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H8Z71_RS16560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H8Z71_RS16565	COG0156	8-amino-7-oxononanoate synthase activity
H8Z71_RS16590	COG0604	alcohol dehydrogenase
H8Z71_RS16595	COG1902	pentaerythritol trinitrate reductase activity
H8Z71_RS16595	COG0446	pyridine nucleotide-disulphide oxidoreductase
H8Z71_RS16605	COG0625	glutathione transferase activity
H8Z71_RS16610	COG0039	L-malate dehydrogenase activity
H8Z71_RS16615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8Z71_RS16620	COG1217	gtp-binding protein TYPA
H8Z71_RS16630	COG0154	amidase activity
H8Z71_RS16640	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H8Z71_RS16655	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H8Z71_RS16660	COG0203	ribosomal protein L17
H8Z71_RS16685	COG0201	protein transport
H8Z71_RS16690	COG0200	Binds to the 23S rRNA
H8Z71_RS16695	COG1841	ribosomal large subunit assembly
H8Z71_RS16705	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8Z71_RS16710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8Z71_RS16715	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8Z71_RS16725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8Z71_RS16730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8Z71_RS16740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8Z71_RS16745	COG0255	Belongs to the universal ribosomal protein uL29 family
H8Z71_RS16750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8Z71_RS16755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8Z71_RS16765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8Z71_RS16770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8Z71_RS16775	COG0089	rRNA binding
H8Z71_RS16780	COG0088	Forms part of the polypeptide exit tunnel
H8Z71_RS16785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8Z71_RS16790	COG0051	transcription antitermination factor activity, RNA binding
H8Z71_RS16795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z71_RS16800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8Z71_RS16805	COG0049	tRNA binding
H8Z71_RS16810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8Z71_RS16815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8Z71_RS16820	COG0085	RNA polymerase activity
H8Z71_RS16825	COG0222	ribosome binding
H8Z71_RS16830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8Z71_RS16835	COG0081	regulation of translation
H8Z71_RS16840	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8Z71_RS16845	COG0250	Participates in transcription elongation, termination and antitermination
H8Z71_RS16860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z71_RS16880	COG0012	GTP binding
H8Z71_RS16885	COG0193	aminoacyl-tRNA hydrolase activity
H8Z71_RS16890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H8Z71_RS16895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8Z71_RS16905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8Z71_RS16910	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H8Z71_RS16920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8Z71_RS16925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8Z71_RS16935	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8Z71_RS16950	COG1254	Belongs to the acylphosphatase family
H8Z71_RS16955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z71_RS16960	COG1295	ribonuclease BN
H8Z71_RS16985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8Z71_RS16990	COG1404	Belongs to the peptidase S8 family
H8Z71_RS16995	COG1404	Belongs to the peptidase S8 family
H8Z71_RS17000	COG1404	Belongs to the peptidase S8 family
H8Z71_RS17005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z71_RS17020	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H8Z71_RS17045	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8Z71_RS17075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z71_RS17075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z71_RS17095	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z71_RS17105	COG3634	alkyl hydroperoxide reductase activity
H8Z71_RS17110	COG0583	DNA-binding transcription factor activity
H8Z71_RS17115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z71_RS17120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8Z71_RS17130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8Z71_RS17140	COG2197	response regulator
H8Z71_RS17145	COG5002	protein histidine kinase activity
H8Z71_RS17145	COG2205	protein histidine kinase activity
H8Z71_RS17145	COG0784	Response regulator, receiver
H8Z71_RS17165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z71_RS17170	COG0697	spore germination
H8Z71_RS17195	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H8Z71_RS17210	COG3386	PFAM SMP-30 Gluconolaconase
H8Z71_RS17230	COG1024	Enoyl-CoA hydratase
H8Z71_RS17245	COG0583	DNA-binding transcription factor activity
H8Z71_RS17250	COG3384	dioxygenase
H8Z71_RS17280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z71_RS17285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z71_RS17300	COG2096	Adenosyltransferase
H8Z71_RS17305	COG0123	including yeast histone deacetylase and acetoin utilization protein
H8Z71_RS17320	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H8Z71_RS17325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z71_RS17330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8Z71_RS17335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8Z71_RS17340	COG2967	ApaG domain
H8Z71_RS17345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8Z71_RS17365	COG0747	negative chemotaxis
H8Z71_RS17390	COG0431	NADPH-dependent FMN reductase
H8Z71_RS17395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z71_RS17405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z71_RS17410	COG1116	anion transmembrane transporter activity
H8Z71_RS17420	COG3829	transcription factor binding
H8Z71_RS17435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H8Z71_RS17440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8Z71_RS17460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8Z71_RS17470	COG0642	Histidine kinase
H8Z71_RS17485	COG4181	ATPase activity
H8Z71_RS17495	COG2175	clavaminate synthase activity
H8Z71_RS17505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H8Z71_RS17510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z71_RS17530	COG4771	TonB-dependent receptor
H8Z71_RS17540	COG0667	Aldo Keto reductase
H8Z71_RS17545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8Z71_RS17550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z71_RS17560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z71_RS17565	COG4106	trans-aconitate 2-methyltransferase activity
H8Z71_RS17575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8Z71_RS17615	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8Z71_RS17625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H8Z71_RS17630	COG2226	methyltransferase
H8Z71_RS17655	COG0366	Alpha amylase catalytic
H8Z71_RS17670	COG3321	synthase
H8Z71_RS17670	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS17670	COG0604	alcohol dehydrogenase
H8Z71_RS17690	COG0494	nUDIX hydrolase
H8Z71_RS17695	COG0653	protein targeting
H8Z71_RS17700	COG0739	heme binding
H8Z71_RS17710	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8Z71_RS17725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H8Z71_RS17730	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z71_RS17735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z71_RS17740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8Z71_RS17750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z71_RS17755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8Z71_RS17760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8Z71_RS17770	COG3116	cell division
H8Z71_RS17775	COG0275	rRNA processing
H8Z71_RS17810	COG0792	nuclease activity
H8Z71_RS17815	COG1988	membrane-bound metal-dependent
H8Z71_RS17820	COG0277	FAD linked oxidase domain protein
H8Z71_RS17840	COG0745	RESPONSE REGULATOR receiver
H8Z71_RS17845	COG2205	protein histidine kinase activity
H8Z71_RS17850	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H8Z71_RS17855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H8Z71_RS17860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H8Z71_RS17880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8Z71_RS17885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z71_RS17890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8Z71_RS17910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z71_RS17910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z71_RS17920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8Z71_RS17925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8Z71_RS17935	COG0488	(ABC) transporter
H8Z71_RS17945	COG0697	spore germination
H8Z71_RS17955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z71_RS17970	COG3791	Glutathione-dependent formaldehyde-activating
H8Z71_RS18000	COG2205	protein histidine kinase activity
H8Z71_RS18015	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z71_RS18020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H8Z71_RS18035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z71_RS18050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8Z71_RS18055	COG1012	belongs to the aldehyde dehydrogenase family
H8Z71_RS18060	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H8Z71_RS18065	COG0617	tRNA 3'-terminal CCA addition
H8Z71_RS18075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8Z71_RS18080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z71_RS18085	COG1609	Transcriptional regulator
H8Z71_RS18095	COG2188	Transcriptional regulator
H8Z71_RS18110	COG3250	beta-galactosidase activity
H8Z71_RS18160	COG1459	type II secretion system
H8Z71_RS18215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8Z71_RS18220	COG4191	Histidine kinase
H8Z71_RS18225	COG0784	Response regulator, receiver
H8Z71_RS18230	COG4251	negative regulation of phosphorylation
H8Z71_RS18235	COG2823	Periplasmic or secreted lipoprotein
H8Z71_RS18245	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H8Z71_RS18280	COG1056	cytidyltransferase-related domain
H8Z71_RS18280	COG1051	belongs to the nudix hydrolase family
H8Z71_RS18290	COG0583	DNA-binding transcription factor activity
H8Z71_RS18305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8Z71_RS18310	COG0321	lipoyl(octanoyl) transferase activity
H8Z71_RS18315	COG2921	Belongs to the UPF0250 family
H8Z71_RS18325	COG1686	Belongs to the peptidase S11 family
H8Z71_RS18330	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8Z71_RS18335	COG2951	lytic endotransglycosylase activity
H8Z71_RS18345	COG0772	Belongs to the SEDS family
H8Z71_RS18360	COG1792	Involved in formation and maintenance of cell shape
H8Z71_RS18365	COG1077	Cell shape determining protein MreB Mrl
H8Z71_RS18370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z71_RS18375	COG3284	Transcriptional regulator
H8Z71_RS18420	COG0308	aminopeptidase N
H8Z71_RS18425	COG3300	MHYT domain
H8Z71_RS18425	COG5001	Diguanylate cyclase
H8Z71_RS18430	COG2226	methyltransferase
H8Z71_RS18455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H8Z71_RS18460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H8Z71_RS18465	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H8Z71_RS18475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8Z71_RS18485	COG2832	Protein of unknown function (DUF454)
H8Z71_RS18495	COG0436	Aminotransferase
H8Z71_RS18500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8Z71_RS18505	COG1505	serine-type exopeptidase activity
H8Z71_RS18530	COG0181	hydroxymethylbilane synthase activity
H8Z71_RS18540	COG3275	phosphorelay sensor kinase activity
H8Z71_RS18550	COG2943	transferase activity, transferring hexosyl groups
H8Z71_RS18565	COG0659	secondary active sulfate transmembrane transporter activity
H8Z71_RS18570	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z71_RS18570	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z71_RS18575	COG0840	transmembrane signaling receptor activity
H8Z71_RS18580	COG5001	Diguanylate cyclase
H8Z71_RS18615	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H8Z71_RS18635	COG1113	amino acid transport
H8Z71_RS18650	COG0697	spore germination
H8Z71_RS18690	COG0823	Involved in the tonB-independent uptake of proteins
H8Z71_RS18690	COG1506	peptidase
H8Z71_RS18695	COG2409	Drug exporters of the RND superfamily
H8Z71_RS18720	COG0435	Glutathione S-transferase
H8Z71_RS18730	COG4221	oxidoreductase activity
H8Z71_RS18745	COG4221	oxidoreductase activity
H8Z71_RS18800	COG1802	Transcriptional regulator
H8Z71_RS18810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8Z71_RS18835	COG3052	prosthetic group binding
H8Z71_RS18865	COG2353	YceI-like domain
H8Z71_RS18870	COG0778	Nitroreductase
H8Z71_RS18885	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z71_RS18890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H8Z71_RS18900	COG3386	PFAM SMP-30 Gluconolaconase
H8Z71_RS18915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8Z71_RS18930	COG0459	protein refolding
H8Z71_RS18945	COG2356	endonuclease I
H8Z71_RS18950	COG0300	oxidoreductase activity
H8Z71_RS18975	COG1324	tolerance protein
H8Z71_RS18985	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8Z71_RS18990	COG0511	ligase activity, forming carbon-carbon bonds
H8Z71_RS19000	COG0439	Biotin carboxylase
H8Z71_RS19015	COG2264	protein methyltransferase activity
H8Z71_RS19035	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H8Z71_RS19040	COG4589	Belongs to the CDS family
H8Z71_RS19065	COG0671	phosphoesterase, PA-phosphatase related
H8Z71_RS19065	COG2453	phosphatase
H8Z71_RS19070	COG2267	carboxylic ester hydrolase activity
H8Z71_RS19075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z71_RS19080	COG0138	bifunctional purine biosynthesis protein purh
H8Z71_RS19090	COG0151	Belongs to the GarS family
H8Z71_RS19100	COG1289	transmembrane transporter activity
H8Z71_RS19105	COG2814	Major facilitator Superfamily
H8Z71_RS19110	COG0583	DNA-binding transcription factor activity
H8Z71_RS19115	COG2814	Major facilitator Superfamily
H8Z71_RS19130	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z71_RS19145	COG0316	Belongs to the HesB IscA family
H8Z71_RS19185	COG1051	belongs to the nudix hydrolase family
H8Z71_RS19200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8Z71_RS19210	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H8Z71_RS19220	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8Z71_RS19225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z71_RS19235	COG0134	indole-3-glycerol-phosphate synthase activity
H8Z71_RS19240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8Z71_RS19265	COG1597	lipid kinase activity
H8Z71_RS19270	COG0456	acetyltransferase
H8Z71_RS19285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H8Z71_RS19290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8Z71_RS19310	COG3179	chitinase
H8Z71_RS19330	COG2111	Na H antiporter
H8Z71_RS19330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z71_RS19335	COG1006	Multisubunit Na H antiporter MnhC subunit
H8Z71_RS19340	COG0651	ATP synthesis coupled electron transport
H8Z71_RS19350	COG2212	antiporter activity
H8Z71_RS19355	COG1320	monovalent cation:proton antiporter activity
H8Z71_RS19370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H8Z71_RS19395	COG3104	oligopeptide transport
H8Z71_RS19400	COG3483	tryptophan 2,3-dioxygenase activity
H8Z71_RS19410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8Z71_RS19425	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8Z71_RS19435	COG0513	Belongs to the DEAD box helicase family
H8Z71_RS19445	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS19450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z71_RS19480	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS19485	COG0702	epimerase
H8Z71_RS19510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z71_RS19515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z71_RS19520	COG0297	glycogen (starch) synthase activity
H8Z71_RS19530	COG2354	Protein conserved in bacteria
H8Z71_RS19535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z71_RS19540	COG1368	sulfuric ester hydrolase activity
H8Z71_RS19545	COG3264	Mechanosensitive ion channel
H8Z71_RS19545	COG1511	domain protein
H8Z71_RS19615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z71_RS19695	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z71_RS19700	COG1040	competence protein
H8Z71_RS19705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8Z71_RS19710	COG0156	8-amino-7-oxononanoate synthase activity
H8Z71_RS19720	COG2267	carboxylic ester hydrolase activity
H8Z71_RS19750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8Z71_RS19760	COG0445	tRNA wobble uridine modification
H8Z71_RS19770	COG0657	acetylesterase activity
H8Z71_RS19780	COG1414	Transcriptional regulator
H8Z71_RS19790	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8Z71_RS19795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z71_RS19805	COG3485	protocatechuate 3,4-dioxygenase
H8Z71_RS19810	COG3485	protocatechuate 3,4-dioxygenase
H8Z71_RS19820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H8Z71_RS19825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8Z71_RS19850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8Z71_RS19855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8Z71_RS19910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8Z71_RS19925	COG0129	dihydroxy-acid dehydratase activity
H8Z71_RS19955	COG1733	regulation of RNA biosynthetic process
H8Z71_RS19960	COG0702	epimerase
H8Z71_RS19990	COG0583	DNA-binding transcription factor activity
H8Z71_RS19995	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z71_RS20000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z71_RS20020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z71_RS20025	COG2205	protein histidine kinase activity
H8Z71_RS20030	COG0745	RESPONSE REGULATOR receiver
H8Z71_RS20050	COG1902	pentaerythritol trinitrate reductase activity
H8Z71_RS20055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8Z71_RS20070	COG2814	Major facilitator Superfamily
H8Z71_RS20075	COG0583	DNA-binding transcription factor activity
H8Z71_RS20090	COG0084	hydrolase, TatD family'
H8Z71_RS20110	COG2252	PERMEase
H8Z71_RS20120	COG1957	nucleoside hydrolase
H8Z71_RS20155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8Z71_RS20175	COG2072	flavoprotein involved in K transport
H8Z71_RS20180	COG2351	hydroxyisourate hydrolase activity
H8Z71_RS20185	COG4807	Protein conserved in bacteria
H8Z71_RS20190	COG1643	Atp-dependent helicase
H8Z71_RS20205	COG1187	pseudouridine synthase activity
H8Z71_RS20220	COG2130	NADP-dependent
H8Z71_RS20245	COG1764	response to oxidative stress
H8Z71_RS20250	COG1846	Transcriptional regulator
H8Z71_RS20255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H8Z71_RS20265	COG0697	spore germination
H8Z71_RS20275	COG0523	cobalamin synthesis protein
H8Z71_RS20330	COG1960	acyl-CoA dehydrogenase activity
H8Z71_RS20335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H8Z71_RS20340	COG4770	biotin carboxylase activity
H8Z71_RS20370	COG2224	Isocitrate lyase
H8Z71_RS20375	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H8Z71_RS20380	COG0583	DNA-binding transcription factor activity
H8Z71_RS20385	COG0475	glutathione-regulated potassium exporter activity
H8Z71_RS20415	COG0339	signal peptide processing
H8Z71_RS20450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z71_RS20460	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z71_RS20470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z71_RS20475	COG0318	PFAM AMP-dependent synthetase and ligase
H8Z71_RS20480	COG0727	PFAM Uncharacterised protein family (UPF0153)
H8Z71_RS20485	COG0596	Alpha beta hydrolase
H8Z71_RS20495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z71_RS20510	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8Z71_RS20535	COG2205	protein histidine kinase activity
H8Z71_RS20540	COG0028	Belongs to the TPP enzyme family
H8Z71_RS20555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8Z71_RS20560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H8Z71_RS20565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8Z71_RS20600	COG0183	Belongs to the thiolase family
H8Z71_RS20610	COG0346	lactoylglutathione lyase activity
H8Z71_RS20620	COG2032	superoxide dismutase activity
H8Z71_RS20625	COG2032	superoxide dismutase activity
H8Z71_RS20630	COG2204	response regulator
H8Z71_RS20635	COG3852	Histidine kinase
H8Z71_RS20640	COG0004	ammonium transporteR
H8Z71_RS20645	COG0347	Belongs to the P(II) protein family
H8Z71_RS20650	COG0174	glutamine synthetase
H8Z71_RS20655	COG1968	undecaprenyl-diphosphatase activity
H8Z71_RS20700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z71_RS20710	COG2062	phosphohistidine phosphatase, SixA
H8Z71_RS20715	COG0489	protein tyrosine kinase activity
H8Z71_RS20735	COG1396	sequence-specific DNA binding
H8Z71_RS20755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z71_RS20770	COG1125	glycine betaine transport
H8Z71_RS20835	COG3237	CsbD-like
H8Z71_RS20880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z71_RS20885	COG0477	Major facilitator Superfamily
H8Z71_RS20925	COG0714	Associated with various cellular activities
H8Z71_RS20960	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H8Z71_RS20970	COG4772	TonB-dependent receptor
H8Z71_RS20980	COG0662	Cupin 2, conserved barrel domain protein
H8Z71_RS20985	COG1012	belongs to the aldehyde dehydrogenase family
H8Z71_RS21010	COG1304	FMN binding
H8Z71_RS21020	COG4585	Histidine kinase
H8Z71_RS21025	COG2197	response regulator
H8Z71_RS21045	COG3710	Transcriptional regulator
H8Z71_RS21050	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8Z71_RS21165	COG0210	DNA helicase
H8Z71_RS21175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z71_RS21180	COG0583	DNA-binding transcription factor activity
H8Z71_RS21185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z71_RS21195	COG2159	amidohydrolase
H8Z71_RS21215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z71_RS21235	COG0357	Ribosomal RNA small subunit methyltransferase G
H8Z71_RS21240	COG3540	Alkaline phosphatase
H8Z71_RS21250	COG2091	lysine biosynthetic process via aminoadipic acid
H8Z71_RS21265	COG0708	Exodeoxyribonuclease III
H8Z71_RS21270	COG1940	carbohydrate kinase activity
H8Z71_RS21270	COG1846	Transcriptional regulator
H8Z71_RS21280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z71_RS21290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8Z71_RS21295	COG3162	membrane
H8Z71_RS21305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8Z71_RS21330	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z71_RS21350	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_RS21355	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8Z71_RS21360	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z71_RS21365	COG3254	rhamnose metabolic process
H8Z71_RS21370	COG0738	Major facilitator superfamily
H8Z71_RS21375	COG1414	Transcriptional regulator
H8Z71_RS21380	COG1971	Probably functions as a manganese efflux pump
H8Z71_RS21385	COG2205	protein histidine kinase activity
H8Z71_RS21395	COG3459	Glycosyltransferase 36 associated
H8Z71_RS21400	COG2211	Major facilitator Superfamily
H8Z71_RS21405	COG3265	gluconokinase activity
H8Z71_RS21410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z71_RS21430	COG2911	Protein conserved in bacteria
H8Z71_RS21435	COG0729	surface antigen
H8Z71_RS21485	COG0752	glycyl-tRNA synthetase alpha subunit
H8Z71_RS21490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z71_RS21500	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z71_RS21500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z71_RS21510	COG0805	protein transport
H8Z71_RS21515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z71_RS21520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z71_RS21530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8Z71_RS21550	COG2974	May be involved in recombination
H8Z71_RS21555	COG0037	tRNA processing
H8Z71_RS21560	COG2115	Belongs to the xylose isomerase family
H8Z71_RS21570	COG3661	Belongs to the glycosyl hydrolase 67 family
H8Z71_RS21580	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z71_RS21590	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z71_RS21595	COG0246	Mannitol dehydrogenase
H8Z71_RS21640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z71_RS21670	COG3386	PFAM SMP-30 Gluconolaconase
H8Z71_RS21680	COG3250	beta-galactosidase activity
H8Z71_RS21685	COG1904	glucuronate isomerase
H8Z71_RS21690	COG3693	PFAM glycoside hydrolase, family 10
H8Z71_RS21700	COG3693	PFAM glycoside hydrolase, family 10
H8Z71_RS21715	COG2211	Major facilitator Superfamily
H8Z71_RS21785	COG2937	Belongs to the GPAT DAPAT family
H8Z71_RS21815	COG0284	orotidine-5'-phosphate decarboxylase activity
H8Z71_RS21820	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H8Z71_RS21825	COG3132	Protein of unknown function, DUF480
H8Z71_RS21840	COG0210	DNA helicase
H8Z71_RS21845	COG1435	thymidine kinase activity
H8Z71_RS21855	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H8Z71_RS21865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8Z71_RS21895	COG3135	benzoate transporter
H8Z71_RS21915	COG0676	glucose-6-phosphate 1-epimerase activity
H8Z71_RS21925	COG3012	SEC-C Motif Domain Protein
H8Z71_RS21930	COG0730	response to heat
H8Z71_RS21950	COG0302	gtp cyclohydrolase
H8Z71_RS21965	COG1566	PFAM secretion protein HlyD family protein
H8Z71_RS21975	COG1289	transmembrane transporter activity
H8Z71_RS21980	COG0477	Major facilitator Superfamily
H8Z71_RS21990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z71_RS22010	COG4691	Plasmid stability protein
H8Z71_RS22015	COG1487	ribonuclease activity
H8Z71_RS22050	COG0564	pseudouridine synthase activity
H8Z71_RS22080	COG0439	Biotin carboxylase
H8Z71_RS22125	COG1074	ATP-dependent DNA helicase activity
H8Z71_RS22130	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H8Z71_RS22145	COG1127	ABC transporter
H8Z71_RS22150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z71_RS22155	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z71_RS22170	COG2853	Lipoprotein
H8Z71_RS22180	COG0386	Belongs to the glutathione peroxidase family
H8Z71_RS22190	COG1322	Protein conserved in bacteria
H8Z71_RS22195	COG0604	alcohol dehydrogenase
H8Z71_RS22210	COG0625	glutathione transferase activity
H8Z71_RS22220	COG0531	amino acid
H8Z71_RS22225	COG3537	Alpha-1,2-mannosidase
H8Z71_RS22235	COG3706	GGDEF domain
H8Z71_RS22240	COG3835	regulator
H8Z71_RS22245	COG1929	Belongs to the glycerate kinase type-1 family
H8Z71_RS22250	COG2271	Major facilitator Superfamily
H8Z71_RS22265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z71_RS22270	COG0861	Integral membrane protein TerC family
H8Z71_RS22280	COG0584	glycerophosphoryl diester phosphodiesterase
H8Z71_RS22295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8Z71_RS22300	COG0726	polysaccharide deacetylase
H8Z71_RS22305	COG0706	membrane insertase activity
H8Z71_RS22310	COG0594	ribonuclease P activity
H8Z71_RS22405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z71_RS22425	COG3012	SEC-C Motif Domain Protein
H8Z71_RS22425	COG3318	Belongs to the UPF0149 family
H8Z71_RS22445	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z71_RS22450	COG4456	Virulence-associated protein
H8Z71_RS22530	COG2948	multi-organism process
H8Z71_RS22535	COG3504	Conjugal transfer protein
H8Z71_RS22545	COG3704	protein secretion by the type IV secretion system
H8Z71_RS22685	COG3451	type IV secretory pathway VirB4
H8Z71_RS22700	COG4962	Type ii secretion system protein e
H8Z71_RS22770	COG0489	protein tyrosine kinase activity
H8Z71_RS22850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8Z71_RS22910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z71_RS22980	COG3704	protein secretion by the type IV secretion system
H8Z71_RS22990	COG3504	Conjugal transfer protein
H8Z71_RS22995	COG2948	multi-organism process
H8Z71_RS23015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z71_RS23085	COG3041	Addiction module toxin RelE StbE family
H8Z71_RS23090	COG3077	Addiction module antitoxin, RelB DinJ family
H8Z71_RS23105	COG1192	Involved in chromosome partitioning
H8Z71_RS23170	COG1192	Involved in chromosome partitioning
H8Z71_RS23215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z71_RS23235	COG3012	SEC-C Motif Domain Protein
H8Z71_RS23235	COG3318	Belongs to the UPF0149 family