locus-tag	class	description
H8Z70_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H8Z70_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8Z70_RS00020	COG0187	DNA topoisomerase II activity
H8Z70_RS00030	COG0501	Belongs to the peptidase M48B family
H8Z70_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8Z70_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z70_RS00115	COG0793	Belongs to the peptidase S41A family
H8Z70_RS00120	COG4942	peptidase
H8Z70_RS00130	COG2234	aminopeptidase activity
H8Z70_RS00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z70_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z70_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z70_RS00165	COG1064	alcohol dehydrogenase
H8Z70_RS00175	COG0493	'glutamate synthase
H8Z70_RS00180	COG0069	glutamate synthase activity
H8Z70_RS00180	COG0070	glutamate synthase
H8Z70_RS00180	COG0067	glutamate synthase
H8Z70_RS00230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8Z70_RS00245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H8Z70_RS00250	COG0297	glycogen (starch) synthase activity
H8Z70_RS00250	COG0438	transferase activity, transferring glycosyl groups
H8Z70_RS00270	COG0367	asparagine synthase
H8Z70_RS00300	COG1132	(ABC) transporter
H8Z70_RS00330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z70_RS00415	COG1111	helicase
H8Z70_RS00415	COG1205	dead DEAH box helicase
H8Z70_RS00420	COG1272	protein, Hemolysin III
H8Z70_RS00440	COG0300	oxidoreductase activity
H8Z70_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS00465	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8Z70_RS00495	COG1119	ATPase activity
H8Z70_RS00505	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8Z70_RS00515	COG1522	sequence-specific DNA binding
H8Z70_RS00520	COG3186	Phenylalanine-4-hydroxylase
H8Z70_RS00535	COG2755	lipolytic protein G-D-S-L family
H8Z70_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS00550	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H8Z70_RS00555	COG1609	Transcriptional regulator
H8Z70_RS00560	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z70_RS00575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H8Z70_RS00585	COG2755	lipolytic protein G-D-S-L family
H8Z70_RS00585	COG0657	acetylesterase activity
H8Z70_RS00605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z70_RS00610	COG0366	Alpha amylase catalytic
H8Z70_RS00615	COG0366	Alpha amylase catalytic
H8Z70_RS00760	COG0631	protein serine/threonine phosphatase activity
H8Z70_RS00765	COG2815	serine threonine protein kinase
H8Z70_RS00765	COG0515	serine threonine protein kinase
H8Z70_RS00800	COG0408	coproporphyrinogen oxidase activity
H8Z70_RS00815	COG4946	Tricorn protease homolog
H8Z70_RS00815	COG0823	Involved in the tonB-independent uptake of proteins
H8Z70_RS00815	COG1506	peptidase
H8Z70_RS00840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8Z70_RS00855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z70_RS00890	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS00910	COG0463	Glycosyl transferase, family 2
H8Z70_RS00920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8Z70_RS00925	COG3100	YcgL domain-containing protein
H8Z70_RS00940	COG3387	PFAM Glycoside hydrolase 15-related
H8Z70_RS00945	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z70_RS00960	COG2239	Acts as a magnesium transporter
H8Z70_RS00965	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z70_RS00965	COG1042	CoA-binding domain protein
H8Z70_RS00965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8Z70_RS00975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z70_RS00980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z70_RS01015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8Z70_RS01025	COG0842	Transport permease protein
H8Z70_RS01030	COG1131	(ABC) transporter
H8Z70_RS01035	COG0633	Ferredoxin
H8Z70_RS01035	COG0543	2 iron, 2 sulfur cluster binding
H8Z70_RS01080	COG1476	TRANSCRIPTIONal
H8Z70_RS01090	COG4555	ABC transporter
H8Z70_RS01125	COG0625	glutathione transferase activity
H8Z70_RS01190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8Z70_RS01205	COG1199	ATP-dependent helicase activity
H8Z70_RS01225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z70_RS01270	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8Z70_RS01285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8Z70_RS01325	COG3237	CsbD-like
H8Z70_RS01330	COG0180	Tryptophanyl-tRNA synthetase
H8Z70_RS01335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z70_RS01350	COG0697	spore germination
H8Z70_RS01375	COG1136	(ABC) transporter
H8Z70_RS01380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z70_RS01385	COG4585	Histidine kinase
H8Z70_RS01390	COG2197	response regulator
H8Z70_RS01405	COG0753	catalase activity
H8Z70_RS01420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z70_RS01425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z70_RS01450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z70_RS01475	COG0642	Histidine kinase
H8Z70_RS01485	COG1090	epimerase
H8Z70_RS01525	COG1690	Belongs to the RtcB family
H8Z70_RS01550	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H8Z70_RS01565	COG0606	chelatase, subunit chli
H8Z70_RS01600	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8Z70_RS01605	COG1166	arginine decarboxylase activity
H8Z70_RS01610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z70_RS01620	COG2755	lipolytic protein G-D-S-L family
H8Z70_RS01620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8Z70_RS01625	COG4221	oxidoreductase activity
H8Z70_RS01640	COG0018	arginyl-trna synthetase
H8Z70_RS01645	COG2003	Belongs to the UPF0758 family
H8Z70_RS01650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8Z70_RS01655	COG0756	dUTP diphosphatase activity
H8Z70_RS01675	COG0463	Glycosyl transferase, family 2
H8Z70_RS01690	COG1475	DNA binding
H8Z70_RS01695	COG1192	Involved in chromosome partitioning
H8Z70_RS01705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8Z70_RS01710	COG0708	Exodeoxyribonuclease III
H8Z70_RS01715	COG2223	nitrite transmembrane transporter activity
H8Z70_RS01725	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H8Z70_RS01730	COG0739	heme binding
H8Z70_RS01735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8Z70_RS01775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8Z70_RS01790	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H8Z70_RS01820	COG0109	protoheme IX farnesyltransferase activity
H8Z70_RS01835	COG0358	DNA primase activity
H8Z70_RS01840	COG1295	ribonuclease BN
H8Z70_RS01845	COG1610	YqeY-like protein
H8Z70_RS01855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8Z70_RS01860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8Z70_RS01870	COG2133	pyrroloquinoline quinone binding
H8Z70_RS01875	COG4682	membrane
H8Z70_RS01890	COG0531	amino acid
H8Z70_RS01900	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z70_RS01910	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8Z70_RS01915	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8Z70_RS01955	COG5383	Protein conserved in bacteria
H8Z70_RS01965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z70_RS01970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z70_RS01975	COG1473	amidohydrolase
H8Z70_RS01980	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z70_RS01980	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z70_RS01985	COG1652	LysM domain
H8Z70_RS01995	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H8Z70_RS02000	COG1518	maintenance of DNA repeat elements
H8Z70_RS02045	COG0583	DNA-binding transcription factor activity
H8Z70_RS02050	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H8Z70_RS02055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H8Z70_RS02060	COG3118	belongs to the thioredoxin family
H8Z70_RS02065	COG0513	Belongs to the DEAD box helicase family
H8Z70_RS02070	COG2884	Cell division ATP-binding protein ftsE
H8Z70_RS02075	COG2177	Part of the ABC transporter FtsEX involved in
H8Z70_RS02080	COG2201	protein-glutamate methylesterase activity
H8Z70_RS02085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H8Z70_RS02090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z70_RS02095	COG2860	membrane
H8Z70_RS02100	COG1252	NADH dehydrogenase
H8Z70_RS02115	COG0625	glutathione transferase activity
H8Z70_RS02120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8Z70_RS02140	COG0534	Mate efflux family protein
H8Z70_RS02145	COG0616	signal peptide processing
H8Z70_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS02170	COG0009	L-threonylcarbamoyladenylate synthase
H8Z70_RS02175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z70_RS02175	COG1754	DNA topoisomerase type I activity
H8Z70_RS02195	COG0758	DNA mediated transformation
H8Z70_RS02200	COG1652	LysM domain
H8Z70_RS02205	COG0242	peptide deformylase activity
H8Z70_RS02210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8Z70_RS02215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8Z70_RS02215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z70_RS02265	COG1560	Kdo2-lipid A biosynthetic process
H8Z70_RS02270	COG1490	D-aminoacyl-tRNA deacylase activity
H8Z70_RS02275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z70_RS02465	COG3179	chitinase
H8Z70_RS02510	COG4695	Portal protein
H8Z70_RS02540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z70_RS02585	COG0024	Methionine aminopeptidase
H8Z70_RS02630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z70_RS02635	COG0583	DNA-binding transcription factor activity
H8Z70_RS02650	COG0840	transmembrane signaling receptor activity
H8Z70_RS02665	COG0251	oxidation-reduction process
H8Z70_RS02740	COG1063	alcohol dehydrogenase
H8Z70_RS02755	COG1132	(ABC) transporter
H8Z70_RS02775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8Z70_RS02780	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS02795	COG1294	oxidase, subunit
H8Z70_RS02800	COG1271	oxidase subunit
H8Z70_RS02845	COG3546	catalase activity
H8Z70_RS02850	COG3685	Protein conserved in bacteria
H8Z70_RS02865	COG2972	Histidine kinase
H8Z70_RS02880	COG0531	amino acid
H8Z70_RS02900	COG3590	peptidase
H8Z70_RS02910	COG0667	Aldo Keto reductase
H8Z70_RS02920	COG0583	DNA-binding transcription factor activity
H8Z70_RS02930	COG3384	dioxygenase
H8Z70_RS02940	COG1573	uracil-dna glycosylase
H8Z70_RS02945	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8Z70_RS02950	COG0025	NhaP-type Na H and K H
H8Z70_RS02955	COG1131	(ABC) transporter
H8Z70_RS02960	COG0842	Transport permease protein
H8Z70_RS03020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z70_RS03025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8Z70_RS03045	COG2205	protein histidine kinase activity
H8Z70_RS03045	COG2202	Pas domain
H8Z70_RS03065	COG2813	Specifically methylates the guanine in position
H8Z70_RS03070	COG1187	pseudouridine synthase activity
H8Z70_RS03075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z70_RS03095	COG5002	protein histidine kinase activity
H8Z70_RS03095	COG2198	Histidine kinase
H8Z70_RS03095	COG0784	Response regulator, receiver
H8Z70_RS03105	COG1666	GTP binding
H8Z70_RS03110	COG0697	spore germination
H8Z70_RS03115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8Z70_RS03160	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8Z70_RS03170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z70_RS03190	COG0356	it plays a direct role in the translocation of protons across the membrane
H8Z70_RS03200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8Z70_RS03205	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8Z70_RS03210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8Z70_RS03215	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8Z70_RS03220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8Z70_RS03225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8Z70_RS03240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8Z70_RS03245	COG4191	Histidine kinase
H8Z70_RS03260	COG0577	efflux transmembrane transporter activity
H8Z70_RS03265	COG0577	efflux transmembrane transporter activity
H8Z70_RS03270	COG1136	(ABC) transporter
H8Z70_RS03270	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z70_RS03275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z70_RS03280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z70_RS03335	COG0339	signal peptide processing
H8Z70_RS03350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z70_RS03355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z70_RS03370	COG2819	hydrolase of the alpha beta superfamily
H8Z70_RS03380	COG1956	GAF domain-containing protein
H8Z70_RS03385	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8Z70_RS03395	COG0720	synthase
H8Z70_RS03400	COG4206	TonB-dependent receptor
H8Z70_RS03410	COG0513	Belongs to the DEAD box helicase family
H8Z70_RS03420	COG0625	glutathione transferase activity
H8Z70_RS03450	COG0626	cystathionine gamma-synthase activity
H8Z70_RS03465	COG0110	maltose O-acetyltransferase activity
H8Z70_RS03470	COG0438	transferase activity, transferring glycosyl groups
H8Z70_RS03470	COG1216	Glycosyl transferase, family 2
H8Z70_RS03475	COG3754	Rhamnan synthesis protein F
H8Z70_RS03485	COG2226	methyltransferase
H8Z70_RS03505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z70_RS03515	COG0300	oxidoreductase activity
H8Z70_RS03520	COG0277	FAD linked oxidase domain protein
H8Z70_RS03525	COG0546	phosphoglycolate phosphatase activity
H8Z70_RS03525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z70_RS03540	COG2086	electron transfer activity
H8Z70_RS03570	COG0662	Cupin 2, conserved barrel domain protein
H8Z70_RS03570	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H8Z70_RS03575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z70_RS03610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z70_RS03610	COG3218	ABC-type transport auxiliary lipoprotein component
H8Z70_RS03615	COG1127	ABC transporter
H8Z70_RS03620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z70_RS03635	COG0442	prolyl-tRNA aminoacylation
H8Z70_RS03645	COG1183	phosphatidylcholine synthase activity
H8Z70_RS03680	COG0525	valine-tRNA ligase activity
H8Z70_RS03695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z70_RS03705	COG0795	lipopolysaccharide-transporting ATPase activity
H8Z70_RS03720	COG4974	Belongs to the 'phage' integrase family
H8Z70_RS03725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z70_RS03730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8Z70_RS03730	COG0047	phosphoribosylformylglycinamidine synthase activity
H8Z70_RS03735	COG5295	Hep Hag repeat protein
H8Z70_RS03740	COG1404	Belongs to the peptidase S8 family
H8Z70_RS03745	COG5295	Hep Hag repeat protein
H8Z70_RS03750	COG1404	Belongs to the peptidase S8 family
H8Z70_RS03755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z70_RS03760	COG1459	type II secretion system
H8Z70_RS03765	COG2165	general secretion pathway protein
H8Z70_RS03770	COG4970	Tfp pilus assembly protein FimT
H8Z70_RS03775	COG2165	general secretion pathway protein
H8Z70_RS03780	COG4795	General secretion pathway protein
H8Z70_RS03785	COG3156	type II secretion system protein K
H8Z70_RS03790	COG3166	PFAM Fimbrial assembly family protein
H8Z70_RS03805	COG1450	Type ii and iii secretion system protein
H8Z70_RS03820	COG2188	Transcriptional regulator
H8Z70_RS03865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H8Z70_RS03880	COG1215	transferase activity, transferring glycosyl groups
H8Z70_RS03885	COG1215	transferase activity, transferring glycosyl groups
H8Z70_RS03890	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H8Z70_RS03895	COG0457	Tetratricopeptide repeat
H8Z70_RS03915	COG0242	peptide deformylase activity
H8Z70_RS03920	COG1307	EDD domain protein, DegV family
H8Z70_RS03955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z70_RS03960	COG0726	polysaccharide deacetylase
H8Z70_RS03965	COG4773	Receptor
H8Z70_RS03985	COG1162	GTPase activity
H8Z70_RS04010	COG2211	Major facilitator Superfamily
H8Z70_RS04015	COG1609	Transcriptional regulator
H8Z70_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS04025	COG2851	Citrate transporter
H8Z70_RS04040	COG0642	Histidine kinase
H8Z70_RS04050	COG2197	response regulator
H8Z70_RS04065	COG0667	Aldo Keto reductase
H8Z70_RS04070	COG0583	DNA-binding transcription factor activity
H8Z70_RS04095	COG1301	dicarboxylic acid transport
H8Z70_RS04100	COG0281	malic enzyme
H8Z70_RS04100	COG0280	phosphate acetyltransferase
H8Z70_RS04125	COG1560	Kdo2-lipid A biosynthetic process
H8Z70_RS04130	COG1519	Transferase
H8Z70_RS04135	COG1538	Outer membrane efflux protein
H8Z70_RS04140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z70_RS04160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8Z70_RS04165	COG0066	3-isopropylmalate dehydratase activity
H8Z70_RS04170	COG0473	3-isopropylmalate dehydrogenase activity
H8Z70_RS04175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8Z70_RS04195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8Z70_RS04200	COG0405	Gamma-glutamyltransferase
H8Z70_RS04205	COG0840	transmembrane signaling receptor activity
H8Z70_RS04215	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8Z70_RS04220	COG3710	Transcriptional regulator
H8Z70_RS04240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8Z70_RS04250	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H8Z70_RS04265	COG0563	adenylate kinase activity
H8Z70_RS04270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z70_RS04280	COG3781	membrane
H8Z70_RS04285	COG0671	phosphoesterase, PA-phosphatase related
H8Z70_RS04295	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS04305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z70_RS04310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8Z70_RS04340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z70_RS04355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z70_RS04370	COG0352	thiamine-phosphate diphosphorylase activity
H8Z70_RS04375	COG1773	rubredoxin
H8Z70_RS04380	COG2912	Transglutaminase-like superfamily
H8Z70_RS04390	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8Z70_RS04400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8Z70_RS04420	COG3079	Belongs to the UPF0149 family
H8Z70_RS04425	COG0006	proline dipeptidase activity
H8Z70_RS04435	COG0006	proline dipeptidase activity
H8Z70_RS04450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8Z70_RS04455	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8Z70_RS04465	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8Z70_RS04470	COG1561	YicC-like family, N-terminal region
H8Z70_RS04475	COG0194	GDP metabolic process
H8Z70_RS04485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z70_RS04495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8Z70_RS04520	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8Z70_RS04550	COG0714	Associated with various cellular activities
H8Z70_RS04570	COG2304	oxidoreductase activity
H8Z70_RS04580	COG1301	dicarboxylic acid transport
H8Z70_RS04585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8Z70_RS04590	COG0596	Alpha beta hydrolase
H8Z70_RS04595	COG4773	Receptor
H8Z70_RS04610	COG0739	heme binding
H8Z70_RS04615	COG1376	ErfK ybiS ycfS ynhG family protein
H8Z70_RS04650	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H8Z70_RS04655	COG4149	molybdate abc transporter
H8Z70_RS04660	COG0725	ABC transporter, periplasmic molybdate-binding protein
H8Z70_RS04665	COG3453	Protein conserved in bacteria
H8Z70_RS04665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z70_RS04675	COG3047	cAMP biosynthetic process
H8Z70_RS04680	COG3047	cAMP biosynthetic process
H8Z70_RS04690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8Z70_RS04710	COG0126	phosphoglycerate kinase activity
H8Z70_RS04720	COG0469	pyruvate kinase activity
H8Z70_RS04725	COG3588	fructose-bisphosphate aldolase
H8Z70_RS04730	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8Z70_RS04745	COG1648	precorrin-2 dehydrogenase activity
H8Z70_RS04745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z70_RS04760	COG2205	protein histidine kinase activity
H8Z70_RS04760	COG2198	Histidine kinase
H8Z70_RS04760	COG0784	Response regulator, receiver
H8Z70_RS04780	COG0175	sulfate reduction
H8Z70_RS04785	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8Z70_RS04790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z70_RS04795	COG0175	sulfate reduction
H8Z70_RS04800	COG2895	sulfate adenylyltransferase (ATP) activity
H8Z70_RS04800	COG0529	Catalyzes the synthesis of activated sulfate
H8Z70_RS04810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z70_RS04845	COG0308	aminopeptidase N
H8Z70_RS04855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z70_RS04870	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z70_RS04875	COG3250	beta-galactosidase activity
H8Z70_RS04895	COG1970	mechanosensitive ion channel activity
H8Z70_RS04915	COG0471	metal ion transport
H8Z70_RS04915	COG3273	potassium ion transport
H8Z70_RS04920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8Z70_RS04925	COG2022	thiamine diphosphate biosynthetic process
H8Z70_RS04960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8Z70_RS05080	COG4191	Histidine kinase
H8Z70_RS05080	COG0784	Response regulator, receiver
H8Z70_RS05085	COG0784	Response regulator, receiver
H8Z70_RS05085	COG4191	Histidine kinase
H8Z70_RS05110	COG2003	Belongs to the UPF0758 family
H8Z70_RS05135	COG3039	Transposase
H8Z70_RS05195	COG0745	RESPONSE REGULATOR receiver
H8Z70_RS05200	COG5002	protein histidine kinase activity
H8Z70_RS05225	COG0237	dephospho-CoA kinase activity
H8Z70_RS05230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8Z70_RS05260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z70_RS05275	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z70_RS05280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8Z70_RS05330	COG4644	lycopene metabolic process
H8Z70_RS05335	COG2951	lytic endotransglycosylase activity
H8Z70_RS05355	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8Z70_RS05355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z70_RS05365	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z70_RS05370	COG0564	pseudouridine synthase activity
H8Z70_RS05385	COG3011	Protein conserved in bacteria
H8Z70_RS05390	COG0840	transmembrane signaling receptor activity
H8Z70_RS05405	COG3387	PFAM Glycoside hydrolase 15-related
H8Z70_RS05410	COG1877	trehalose-phosphatase activity
H8Z70_RS05450	COG2827	Endonuclease containing a URI domain
H8Z70_RS05455	COG4771	TonB-dependent receptor
H8Z70_RS05460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z70_RS05465	COG0667	Aldo Keto reductase
H8Z70_RS05470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8Z70_RS05475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z70_RS05480	COG1116	anion transmembrane transporter activity
H8Z70_RS05485	COG0542	response to heat
H8Z70_RS05490	COG4206	TonB-dependent receptor
H8Z70_RS05510	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z70_RS05520	COG1492	cobalamin metabolic process
H8Z70_RS05530	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8Z70_RS05555	COG0019	diaminopimelate decarboxylase activity
H8Z70_RS05570	COG4264	IucA IucC family
H8Z70_RS05580	COG4772	TonB-dependent receptor
H8Z70_RS05605	COG4651	solute:proton antiporter activity
H8Z70_RS05605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z70_RS05635	COG0488	(ABC) transporter
H8Z70_RS05675	COG0477	Major facilitator Superfamily
H8Z70_RS05690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8Z70_RS05705	COG0217	transcriptional regulatory protein
H8Z70_RS05710	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8Z70_RS05715	COG0632	four-way junction helicase activity
H8Z70_RS05720	COG3158	transport of potassium into the cell
H8Z70_RS05730	COG2255	four-way junction helicase activity
H8Z70_RS05735	COG0824	Thioesterase
H8Z70_RS05745	COG0848	biopolymer transport protein
H8Z70_RS05755	COG0823	Involved in the tonB-independent uptake of proteins
H8Z70_RS05760	COG2885	chlorophyll binding
H8Z70_RS05770	COG0602	queuosine metabolic process
H8Z70_RS05780	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8Z70_RS05785	COG3920	Histidine kinase
H8Z70_RS05805	COG0840	transmembrane signaling receptor activity
H8Z70_RS05835	COG0514	ATP-dependent DNA helicase (RecQ)
H8Z70_RS05840	COG0783	Belongs to the Dps family
H8Z70_RS05845	COG1643	Atp-dependent helicase
H8Z70_RS05860	COG0837	glucose binding
H8Z70_RS05875	COG0535	radical SAM domain protein
H8Z70_RS05880	COG0535	radical SAM domain protein
H8Z70_RS05885	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H8Z70_RS05890	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H8Z70_RS05900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z70_RS05910	COG1215	transferase activity, transferring glycosyl groups
H8Z70_RS05915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z70_RS05925	COG1199	ATP-dependent helicase activity
H8Z70_RS05945	COG0189	ligase activity
H8Z70_RS05960	COG0835	chemotaxis
H8Z70_RS05965	COG0840	transmembrane signaling receptor activity
H8Z70_RS05990	COG1446	asparaginase
H8Z70_RS05995	COG3142	Participates in the control of copper homeostasis
H8Z70_RS06030	COG3537	Alpha-1,2-mannosidase
H8Z70_RS06040	COG1486	melibiose metabolic process
H8Z70_RS06050	COG0531	amino acid
H8Z70_RS06065	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z70_RS06075	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H8Z70_RS06080	COG1388	LysM domain
H8Z70_RS06080	COG3858	chitin binding
H8Z70_RS06095	COG0837	glucose binding
H8Z70_RS06100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8Z70_RS06110	COG0494	nUDIX hydrolase
H8Z70_RS06120	COG3956	TIGRFAM MazG family protein
H8Z70_RS06125	COG1742	UPF0060 membrane protein
H8Z70_RS06130	COG0330	HflC and HflK could
H8Z70_RS06140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8Z70_RS06145	COG0509	glycine decarboxylation via glycine cleavage system
H8Z70_RS06175	COG1960	acyl-CoA dehydrogenase activity
H8Z70_RS06185	COG1309	transcriptional regulator
H8Z70_RS06195	COG4771	TonB-dependent receptor
H8Z70_RS06205	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8Z70_RS06210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z70_RS06215	COG0463	Glycosyl transferase, family 2
H8Z70_RS06220	COG0517	IMP dehydrogenase activity
H8Z70_RS06220	COG0516	GMP reductase activity
H8Z70_RS06225	COG2982	Protein involved in outer membrane biogenesis
H8Z70_RS06230	COG1272	protein, Hemolysin III
H8Z70_RS06235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8Z70_RS06240	COG0739	heme binding
H8Z70_RS06245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z70_RS06250	COG0626	cystathionine gamma-synthase activity
H8Z70_RS06255	COG0527	aspartate kinase activity
H8Z70_RS06255	COG0460	homoserine dehydrogenase
H8Z70_RS06265	COG1760	l-serine dehydratase
H8Z70_RS06285	COG2353	YceI-like domain
H8Z70_RS06290	COG0784	Response regulator, receiver
H8Z70_RS06290	COG2205	protein histidine kinase activity
H8Z70_RS06290	COG2198	Histidine kinase
H8Z70_RS06310	COG0477	Major facilitator Superfamily
H8Z70_RS06395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8Z70_RS06405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8Z70_RS06410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8Z70_RS06415	COG0259	pyridoxamine-phosphate oxidase activity
H8Z70_RS06425	COG1842	Phage shock protein A
H8Z70_RS06450	COG0754	glutathionylspermidine amidase activity
H8Z70_RS06460	COG2814	Major facilitator Superfamily
H8Z70_RS06495	COG1234	tRNA 3'-trailer cleavage
H8Z70_RS06515	COG0531	amino acid
H8Z70_RS06525	COG2197	response regulator
H8Z70_RS06545	COG1113	amino acid transport
H8Z70_RS06555	COG1271	oxidase subunit
H8Z70_RS06560	COG1294	oxidase, subunit
H8Z70_RS06575	COG2239	Acts as a magnesium transporter
H8Z70_RS06580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z70_RS06585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z70_RS06595	COG1660	Displays ATPase and GTPase activities
H8Z70_RS06600	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z70_RS06605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z70_RS06620	COG1137	ATPase activity
H8Z70_RS06625	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H8Z70_RS06635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8Z70_RS06645	COG0271	Belongs to the BolA IbaG family
H8Z70_RS06650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8Z70_RS06670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8Z70_RS06680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8Z70_RS06690	COG0628	permease
H8Z70_RS06700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8Z70_RS06705	COG3178	'Phosphotransferase
H8Z70_RS06715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z70_RS06720	COG1555	photosystem II stabilization
H8Z70_RS06735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z70_RS06740	COG1477	protein flavinylation
H8Z70_RS06765	COG3128	pkhd-type hydroxylase
H8Z70_RS06770	COG4774	siderophore transport
H8Z70_RS06775	COG2146	nitrite reductase [NAD(P)H] activity
H8Z70_RS06785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8Z70_RS06790	COG0719	Fe-S assembly protein
H8Z70_RS06795	COG0396	ATPase activity
H8Z70_RS06800	COG0719	Fe-S assembly protein
H8Z70_RS06805	COG1959	2 iron, 2 sulfur cluster binding
H8Z70_RS06815	COG0693	protein deglycase activity
H8Z70_RS06835	COG0739	heme binding
H8Z70_RS06850	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8Z70_RS06865	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z70_RS06880	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z70_RS06885	COG1678	Uncharacterized ACR, COG1678
H8Z70_RS06890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8Z70_RS06895	COG0540	Belongs to the ATCase OTCase family
H8Z70_RS06900	COG1764	response to oxidative stress
H8Z70_RS06910	COG0384	phenazine biosynthesis protein PhzF
H8Z70_RS06915	COG0384	phenazine biosynthesis protein PhzF
H8Z70_RS06920	COG0527	aspartate kinase activity
H8Z70_RS06935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8Z70_RS06945	COG0142	geranyltranstransferase activity
H8Z70_RS06950	COG0629	single-stranded DNA binding
H8Z70_RS06955	COG3706	GGDEF domain
H8Z70_RS06955	COG4251	negative regulation of phosphorylation
H8Z70_RS06955	COG2203	Gaf domain
H8Z70_RS06955	COG5001	Diguanylate cyclase
H8Z70_RS06975	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z70_RS06980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z70_RS06985	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H8Z70_RS07020	COG2879	small protein
H8Z70_RS07025	COG1966	Carbon starvation protein
H8Z70_RS07030	COG1741	Belongs to the pirin family
H8Z70_RS07045	COG1741	Belongs to the pirin family
H8Z70_RS07055	COG1515	deoxyribonuclease V activity
H8Z70_RS07060	COG0588	phosphoglycerate mutase activity
H8Z70_RS07070	COG3590	peptidase
H8Z70_RS07075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z70_RS07080	COG2201	protein-glutamate methylesterase activity
H8Z70_RS07085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z70_RS07090	COG2202	Pas domain
H8Z70_RS07090	COG2199	diguanylate cyclase activity
H8Z70_RS07090	COG2200	EAL domain
H8Z70_RS07095	COG0835	chemotaxis
H8Z70_RS07100	COG0840	transmembrane signaling receptor activity
H8Z70_RS07105	COG2198	Histidine kinase
H8Z70_RS07105	COG0643	Histidine kinase
H8Z70_RS07135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8Z70_RS07145	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H8Z70_RS07150	COG0745	RESPONSE REGULATOR receiver
H8Z70_RS07155	COG2205	protein histidine kinase activity
H8Z70_RS07170	COG4452	Inner membrane protein CreD
H8Z70_RS07195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z70_RS07200	COG0735	belongs to the Fur family
H8Z70_RS07215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z70_RS07225	COG1309	transcriptional regulator
H8Z70_RS07235	COG2207	Transcriptional regulator
H8Z70_RS07245	COG0583	DNA-binding transcription factor activity
H8Z70_RS07250	COG2814	Major facilitator Superfamily
H8Z70_RS07255	COG0667	Aldo Keto reductase
H8Z70_RS07325	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8Z70_RS07375	COG5001	Diguanylate cyclase
H8Z70_RS07375	COG5002	protein histidine kinase activity
H8Z70_RS07380	COG1187	pseudouridine synthase activity
H8Z70_RS07400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z70_RS07410	COG0475	glutathione-regulated potassium exporter activity
H8Z70_RS07415	COG5000	phosphorelay sensor kinase activity
H8Z70_RS07415	COG5002	protein histidine kinase activity
H8Z70_RS07420	COG0745	RESPONSE REGULATOR receiver
H8Z70_RS07425	COG1538	Outer membrane efflux protein
H8Z70_RS07455	COG1132	(ABC) transporter
H8Z70_RS07510	COG2155	Conserved Protein
H8Z70_RS07535	COG3118	belongs to the thioredoxin family
H8Z70_RS07545	COG0495	leucyl-tRNA aminoacylation
H8Z70_RS07560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8Z70_RS07575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8Z70_RS07590	COG2968	Membrane
H8Z70_RS07595	COG0424	maF-like protein
H8Z70_RS07605	COG3164	Protein of unknown function
H8Z70_RS07615	COG0312	modulator of DNA gyrase
H8Z70_RS07620	COG3028	Belongs to the UPF0307 family
H8Z70_RS07625	COG0312	modulator of DNA gyrase
H8Z70_RS07635	COG4104	PAAR repeat-containing protein
H8Z70_RS07640	COG0142	geranyltranstransferase activity
H8Z70_RS07645	COG1722	exodeoxyribonuclease VII activity
H8Z70_RS07650	COG0037	tRNA processing
H8Z70_RS07655	COG1785	Belongs to the alkaline phosphatase family
H8Z70_RS07660	COG1301	dicarboxylic acid transport
H8Z70_RS07665	COG4106	trans-aconitate 2-methyltransferase activity
H8Z70_RS07675	COG0791	NLP P60 protein
H8Z70_RS07680	COG0791	NLP P60 protein
H8Z70_RS07685	COG1047	Peptidyl-prolyl cis-trans
H8Z70_RS07690	COG2311	Membrane
H8Z70_RS07695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z70_RS07700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z70_RS07720	COG3590	peptidase
H8Z70_RS07725	COG3590	peptidase
H8Z70_RS07745	COG0489	protein tyrosine kinase activity
H8Z70_RS07750	COG0717	Belongs to the dCTP deaminase family
H8Z70_RS07780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z70_RS07795	COG0494	nUDIX hydrolase
H8Z70_RS07800	COG0433	COG0433 Predicted ATPase
H8Z70_RS07810	COG0688	phosphatidylethanolamine metabolic process
H8Z70_RS07820	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z70_RS07825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8Z70_RS07830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8Z70_RS07835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8Z70_RS07855	COG0101	tRNA pseudouridine synthase activity
H8Z70_RS07860	COG0135	phosphoribosylanthranilate isomerase activity
H8Z70_RS07870	COG0133	tryptophan synthase activity
H8Z70_RS07880	COG0159	tryptophan synthase activity
H8Z70_RS07885	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8Z70_RS07890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z70_RS07920	COG0300	oxidoreductase activity
H8Z70_RS07925	COG0149	triose-phosphate isomerase activity
H8Z70_RS07940	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z70_RS07945	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z70_RS07950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z70_RS07955	COG0649	NAD binding
H8Z70_RS07960	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H8Z70_RS07965	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H8Z70_RS07975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8Z70_RS07980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z70_RS08005	COG1007	ATP synthesis coupled electron transport
H8Z70_RS08015	COG0779	Required for maturation of 30S ribosomal subunits
H8Z70_RS08020	COG0195	Participates in both transcription termination and antitermination
H8Z70_RS08025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8Z70_RS08030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8Z70_RS08035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8Z70_RS08040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8Z70_RS08045	COG1185	polyribonucleotide nucleotidyltransferase activity
H8Z70_RS08080	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z70_RS08090	COG2095	MarC family integral membrane protein
H8Z70_RS08100	COG1611	Belongs to the LOG family
H8Z70_RS08105	COG3275	phosphorelay sensor kinase activity
H8Z70_RS08195	COG3179	chitinase
H8Z70_RS08240	COG4695	Portal protein
H8Z70_RS08330	COG0556	nucleotide-excision repair
H8Z70_RS08345	COG3505	Type IV secretory pathway VirD4
H8Z70_RS08365	COG2948	multi-organism process
H8Z70_RS08385	COG3702	type iv secretory pathway
H8Z70_RS08440	COG0366	Alpha amylase catalytic
H8Z70_RS08455	COG1082	Xylose isomerase domain protein TIM barrel
H8Z70_RS08480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8Z70_RS08485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8Z70_RS08500	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8Z70_RS08505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z70_RS08505	COG0072	phenylalanine-tRNA ligase activity
H8Z70_RS08555	COG0438	transferase activity, transferring glycosyl groups
H8Z70_RS08560	COG0438	transferase activity, transferring glycosyl groups
H8Z70_RS08570	COG0438	transferase activity, transferring glycosyl groups
H8Z70_RS08595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z70_RS08600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z70_RS08605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z70_RS08625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8Z70_RS08635	COG1960	acyl-CoA dehydrogenase activity
H8Z70_RS08650	COG3040	lipid binding
H8Z70_RS08665	COG0322	excinuclease ABC activity
H8Z70_RS08680	COG0784	Response regulator, receiver
H8Z70_RS08680	COG4191	Histidine kinase
H8Z70_RS08685	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H8Z70_RS08690	COG1194	a g-specific adenine glycosylase
H8Z70_RS08695	COG0552	protein localization to endoplasmic reticulum
H8Z70_RS08705	COG3938	Belongs to the proline racemase family
H8Z70_RS08710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z70_RS08725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z70_RS08735	COG0006	proline dipeptidase activity
H8Z70_RS08750	COG0531	amino acid
H8Z70_RS08830	COG0326	Molecular chaperone. Has ATPase activity
H8Z70_RS08835	COG0742	ribosomal rna small subunit methyltransferase
H8Z70_RS08840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8Z70_RS08850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8Z70_RS08855	COG0405	Gamma-glutamyltransferase
H8Z70_RS08860	COG3291	Pkd domain containing protein
H8Z70_RS08865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8Z70_RS08900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8Z70_RS08905	COG0343	queuine tRNA-ribosyltransferase activity
H8Z70_RS08910	COG1862	Preprotein translocase
H8Z70_RS08920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8Z70_RS08965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z70_RS08965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z70_RS08970	COG1105	Belongs to the carbohydrate kinase PfkB family
H8Z70_RS08975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z70_RS08975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z70_RS08980	COG1609	Transcriptional regulator
H8Z70_RS08985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z70_RS08990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z70_RS09000	COG2902	Dehydrogenase
H8Z70_RS09010	COG0477	Major facilitator Superfamily
H8Z70_RS09020	COG0784	Response regulator, receiver
H8Z70_RS09020	COG2205	protein histidine kinase activity
H8Z70_RS09020	COG5002	protein histidine kinase activity
H8Z70_RS09025	COG2733	membrane
H8Z70_RS09035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8Z70_RS09040	COG2223	nitrite transmembrane transporter activity
H8Z70_RS09045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H8Z70_RS09050	COG0243	molybdopterin cofactor binding
H8Z70_RS09060	COG0477	Major facilitator Superfamily
H8Z70_RS09065	COG2703	oxygen carrier activity
H8Z70_RS09075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z70_RS09080	COG0174	glutamine synthetase
H8Z70_RS09085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H8Z70_RS09100	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H8Z70_RS09120	COG3842	ATPase activity
H8Z70_RS09125	COG1176	ABC-type spermidine putrescine transport system, permease component I
H8Z70_RS09130	COG1177	transmembrane transport
H8Z70_RS09135	COG1012	belongs to the aldehyde dehydrogenase family
H8Z70_RS09150	COG4535	Mg2 and Co2 transporter CorC
H8Z70_RS09160	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8Z70_RS09170	COG1702	phosphate starvation-inducible protein PhoH
H8Z70_RS09175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z70_RS09190	COG0741	lytic transglycosylase activity
H8Z70_RS09195	COG0723	plastoquinol--plastocyanin reductase activity
H8Z70_RS09200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8Z70_RS09205	COG2857	Cytochrome c1
H8Z70_RS09210	COG0625	glutathione transferase activity
H8Z70_RS09215	COG2969	positive regulation of protein catabolic process
H8Z70_RS09235	COG1201	RNA secondary structure unwinding
H8Z70_RS09240	COG2094	Belongs to the DNA glycosylase MPG family
H8Z70_RS09245	COG0840	transmembrane signaling receptor activity
H8Z70_RS09250	COG0835	chemotaxis
H8Z70_RS09330	COG2226	methyltransferase
H8Z70_RS09330	COG1073	alpha beta
H8Z70_RS09340	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS09455	COG1238	metal cluster binding
H8Z70_RS09490	COG3279	Response regulator of the LytR AlgR family
H8Z70_RS09530	COG4566	intracellular signal transduction
H8Z70_RS09540	COG5001	Diguanylate cyclase
H8Z70_RS09560	COG3685	Protein conserved in bacteria
H8Z70_RS09585	COG1648	precorrin-2 dehydrogenase activity
H8Z70_RS09585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z70_RS09600	COG2814	Major facilitator Superfamily
H8Z70_RS09615	COG1335	isochorismatase
H8Z70_RS09635	COG2197	response regulator
H8Z70_RS09655	COG0583	DNA-binding transcription factor activity
H8Z70_RS09660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z70_RS09665	COG3002	Belongs to the UPF0753 family
H8Z70_RS09680	COG1396	sequence-specific DNA binding
H8Z70_RS09685	COG5489	Protein of unknown function (DUF736)
H8Z70_RS09695	COG2003	Belongs to the UPF0758 family
H8Z70_RS09725	COG0582	viral genome integration into host DNA
H8Z70_RS09730	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z70_RS09730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z70_RS09740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8Z70_RS09750	COG0475	glutathione-regulated potassium exporter activity
H8Z70_RS09750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z70_RS09755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8Z70_RS09765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z70_RS09770	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H8Z70_RS09780	COG0776	regulation of translation
H8Z70_RS09785	COG0539	negative regulation of cytoplasmic translation
H8Z70_RS09790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8Z70_RS09805	COG2957	Belongs to the agmatine deiminase family
H8Z70_RS09810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z70_RS09835	COG0395	ABC-type sugar transport system, permease component
H8Z70_RS09840	COG1175	transmembrane transport
H8Z70_RS09870	COG2350	Protein conserved in bacteria
H8Z70_RS09875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H8Z70_RS09880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H8Z70_RS09885	COG1187	pseudouridine synthase activity
H8Z70_RS09905	COG0436	Aminotransferase
H8Z70_RS09910	COG4133	protoheme IX ABC transporter activity
H8Z70_RS09930	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z70_RS09935	COG1138	Cytochrome C-type biogenesis protein
H8Z70_RS09955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z70_RS09960	COG1278	Cold shock
H8Z70_RS09965	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8Z70_RS09970	COG4988	ABC transporter
H8Z70_RS10015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8Z70_RS10020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8Z70_RS10030	COG0165	Argininosuccinate lyase
H8Z70_RS10035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8Z70_RS10045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8Z70_RS10050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z70_RS10060	COG0137	argininosuccinate synthase activity
H8Z70_RS10065	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8Z70_RS10075	COG0215	cysteine-tRNA ligase activity
H8Z70_RS10080	COG2166	iron-sulfur cluster assembly
H8Z70_RS10095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8Z70_RS10100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8Z70_RS10130	COG4302	ethanolamine ammonia-lyase activity
H8Z70_RS10185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8Z70_RS10190	COG0402	S-adenosylhomocysteine deaminase activity
H8Z70_RS10200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z70_RS10205	COG1509	lysine 2,3-aminomutase activity
H8Z70_RS10210	COG5001	Diguanylate cyclase
H8Z70_RS10210	COG3300	MHYT domain
H8Z70_RS10225	COG0483	inositol monophosphate 1-phosphatase activity
H8Z70_RS10230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8Z70_RS10245	COG0488	(ABC) transporter
H8Z70_RS10250	COG0513	Belongs to the DEAD box helicase family
H8Z70_RS10255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8Z70_RS10260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H8Z70_RS10275	COG0625	glutathione transferase activity
H8Z70_RS10285	COG4681	YaeQ
H8Z70_RS10290	COG2081	HI0933 family
H8Z70_RS10300	COG0501	Belongs to the peptidase M48B family
H8Z70_RS10305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z70_RS10310	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS10335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H8Z70_RS10340	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z70_RS10345	COG0802	atpase or kinase
H8Z70_RS10350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z70_RS10350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8Z70_RS10355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z70_RS10360	COG1570	exodeoxyribonuclease VII activity
H8Z70_RS10370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z70_RS10525	COG0316	Belongs to the HesB IscA family
H8Z70_RS10525	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8Z70_RS10530	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8Z70_RS10540	COG0428	transporter
H8Z70_RS10545	COG3064	Membrane
H8Z70_RS10555	COG1530	ribonuclease E activity
H8Z70_RS10565	COG1054	Belongs to the UPF0176 family
H8Z70_RS10585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H8Z70_RS10595	COG0582	viral genome integration into host DNA
H8Z70_RS10610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z70_RS10615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z70_RS10700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8Z70_RS10765	COG0629	single-stranded DNA binding
H8Z70_RS10770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z70_RS10775	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z70_RS10950	COG2003	Belongs to the UPF0758 family
H8Z70_RS11055	COG0583	DNA-binding transcription factor activity
H8Z70_RS11060	COG1396	sequence-specific DNA binding
H8Z70_RS11070	COG0582	viral genome integration into host DNA
H8Z70_RS11080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z70_RS11085	COG0322	excinuclease ABC activity
H8Z70_RS11095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8Z70_RS11100	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H8Z70_RS11105	COG1663	tetraacyldisaccharide 4'-kinase activity
H8Z70_RS11110	COG1132	(ABC) transporter
H8Z70_RS11120	COG0811	peptide transport
H8Z70_RS11135	COG1136	(ABC) transporter
H8Z70_RS11140	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z70_RS11150	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H8Z70_RS11155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8Z70_RS11170	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H8Z70_RS11195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z70_RS11200	COG0837	glucose binding
H8Z70_RS11205	COG0363	glucosamine-6-phosphate deaminase activity
H8Z70_RS11210	COG0129	dihydroxy-acid dehydratase activity
H8Z70_RS11215	COG0800	Aldolase
H8Z70_RS11285	COG0784	Response regulator, receiver
H8Z70_RS11285	COG2205	protein histidine kinase activity
H8Z70_RS11290	COG2183	response to ionizing radiation
H8Z70_RS11300	COG0723	plastoquinol--plastocyanin reductase activity
H8Z70_RS11300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z70_RS11315	COG3243	poly(R)-hydroxyalkanoic acid synthase
H8Z70_RS11325	COG1183	phosphatidylcholine synthase activity
H8Z70_RS11330	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS11345	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H8Z70_RS11355	COG0668	transmembrane transport
H8Z70_RS11360	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H8Z70_RS11375	COG1914	H( )-stimulated, divalent metal cation uptake system
H8Z70_RS11390	COG0746	molybdenum cofactor guanylyltransferase activity
H8Z70_RS11395	COG0303	'Molybdopterin
H8Z70_RS11405	COG0708	Exodeoxyribonuclease III
H8Z70_RS11440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8Z70_RS11445	COG0303	'Molybdopterin
H8Z70_RS11450	COG1160	GTP binding
H8Z70_RS11455	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z70_RS11465	COG1426	Protein conserved in bacteria
H8Z70_RS11475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8Z70_RS11490	COG1024	Enoyl-CoA hydratase
H8Z70_RS11490	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z70_RS11495	COG0183	Belongs to the thiolase family
H8Z70_RS11500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8Z70_RS11505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H8Z70_RS11515	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H8Z70_RS11525	COG1674	ftsk spoiiie
H8Z70_RS11530	COG0492	ferredoxin-NADP+ reductase activity
H8Z70_RS11540	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H8Z70_RS11550	COG0542	response to heat
H8Z70_RS11565	COG0482	sulfurtransferase activity
H8Z70_RS11570	COG2915	High frequency lysogenization protein hflD homolog
H8Z70_RS11600	COG5002	protein histidine kinase activity
H8Z70_RS11620	COG0784	Response regulator, receiver
H8Z70_RS11620	COG0835	chemotaxis
H8Z70_RS11630	COG1558	bacterial-type flagellum-dependent cell motility
H8Z70_RS11635	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H8Z70_RS11645	COG4787	bacterial-type flagellum-dependent cell motility
H8Z70_RS11655	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H8Z70_RS11660	COG1706	bacterial-type flagellum-dependent cell motility
H8Z70_RS11665	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8Z70_RS11665	COG3951	Flagellar rod assembly protein muramidase FlgJ
H8Z70_RS11675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z70_RS11680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z70_RS11690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H8Z70_RS11720	COG2201	protein-glutamate methylesterase activity
H8Z70_RS11740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z70_RS11745	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS11750	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS11780	COG1677	Flagellar hook-basal body complex protein FliE
H8Z70_RS11830	COG3190	flagellar
H8Z70_RS11845	COG1684	flagellar biosynthetic protein fliR
H8Z70_RS11870	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z70_RS11900	COG0643	Histidine kinase
H8Z70_RS11900	COG0784	Response regulator, receiver
H8Z70_RS11900	COG2198	Histidine kinase
H8Z70_RS11910	COG0641	radical SAM
H8Z70_RS11995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8Z70_RS12000	COG1360	Flagellar Motor Protein
H8Z70_RS12010	COG0835	chemotaxis
H8Z70_RS12020	COG0745	RESPONSE REGULATOR receiver
H8Z70_RS12025	COG0643	Histidine kinase
H8Z70_RS12025	COG2198	Histidine kinase
H8Z70_RS12030	COG0840	transmembrane signaling receptor activity
H8Z70_RS12045	COG0840	transmembrane signaling receptor activity
H8Z70_RS12055	COG0840	transmembrane signaling receptor activity
H8Z70_RS12060	COG0840	transmembrane signaling receptor activity
H8Z70_RS12065	COG0840	transmembrane signaling receptor activity
H8Z70_RS12070	COG0840	transmembrane signaling receptor activity
H8Z70_RS12075	COG0840	transmembrane signaling receptor activity
H8Z70_RS12080	COG0840	transmembrane signaling receptor activity
H8Z70_RS12085	COG0840	transmembrane signaling receptor activity
H8Z70_RS12090	COG0840	transmembrane signaling receptor activity
H8Z70_RS12095	COG0840	transmembrane signaling receptor activity
H8Z70_RS12105	COG0835	chemotaxis
H8Z70_RS12115	COG0840	transmembrane signaling receptor activity
H8Z70_RS12125	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H8Z70_RS12130	COG2201	protein-glutamate methylesterase activity
H8Z70_RS12140	COG2267	carboxylic ester hydrolase activity
H8Z70_RS12170	COG0318	PFAM AMP-dependent synthetase and ligase
H8Z70_RS12175	COG1024	Enoyl-CoA hydratase
H8Z70_RS12180	COG0784	Response regulator, receiver
H8Z70_RS12180	COG2198	Histidine kinase
H8Z70_RS12180	COG2205	protein histidine kinase activity
H8Z70_RS12190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8Z70_RS12200	COG3279	Response regulator of the LytR AlgR family
H8Z70_RS12240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8Z70_RS12250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z70_RS12255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8Z70_RS12265	COG0505	Belongs to the CarA family
H8Z70_RS12270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8Z70_RS12275	COG2258	MOSC domain
H8Z70_RS12280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z70_RS12325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z70_RS12345	COG0277	FAD linked oxidase domain protein
H8Z70_RS12350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8Z70_RS12360	COG0531	amino acid
H8Z70_RS12365	COG0531	amino acid
H8Z70_RS12370	COG0235	Class ii aldolase
H8Z70_RS12375	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8Z70_RS12380	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8Z70_RS12395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8Z70_RS12395	COG0140	phosphoribosyl-ATP diphosphatase activity
H8Z70_RS12400	COG0107	imidazoleglycerol-phosphate synthase activity
H8Z70_RS12405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8Z70_RS12410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8Z70_RS12415	COG0131	Imidazoleglycerol-phosphate dehydratase
H8Z70_RS12415	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8Z70_RS12420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z70_RS12425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8Z70_RS12430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8Z70_RS12440	COG0124	histidyl-tRNA synthetase
H8Z70_RS12445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z70_RS12495	COG3210	domain, Protein
H8Z70_RS12505	COG3210	domain, Protein
H8Z70_RS12520	COG1649	PFAM Uncharacterised BCR, COG1649
H8Z70_RS12520	COG0726	polysaccharide deacetylase
H8Z70_RS12525	COG1215	transferase activity, transferring glycosyl groups
H8Z70_RS12540	COG1012	belongs to the aldehyde dehydrogenase family
H8Z70_RS12555	COG0167	dihydroorotate dehydrogenase activity
H8Z70_RS12560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8Z70_RS12565	COG0697	spore germination
H8Z70_RS12570	COG1794	racemase activity, acting on amino acids and derivatives
H8Z70_RS12585	COG0671	phosphoesterase, PA-phosphatase related
H8Z70_RS12590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8Z70_RS12600	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H8Z70_RS12605	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z70_RS12615	COG5001	Diguanylate cyclase
H8Z70_RS12615	COG2203	Gaf domain
H8Z70_RS12615	COG4251	negative regulation of phosphorylation
H8Z70_RS12615	COG3706	GGDEF domain
H8Z70_RS12625	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z70_RS12645	COG0166	Belongs to the GPI family
H8Z70_RS12650	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H8Z70_RS12655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8Z70_RS12660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8Z70_RS12680	COG1469	GTP cyclohydrolase I activity
H8Z70_RS12685	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z70_RS12705	COG0477	Major facilitator Superfamily
H8Z70_RS12710	COG2115	Belongs to the xylose isomerase family
H8Z70_RS12715	COG1070	Carbohydrate kinase
H8Z70_RS12725	COG1501	Belongs to the glycosyl hydrolase 31 family
H8Z70_RS12760	COG0800	Aldolase
H8Z70_RS12765	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z70_RS12775	COG3734	2-keto-3-deoxy-galactonokinase
H8Z70_RS12780	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8Z70_RS12790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z70_RS12805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8Z70_RS12810	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8Z70_RS12825	COG0351	phosphomethylpyrimidine kinase
H8Z70_RS12825	COG0352	thiamine-phosphate diphosphorylase activity
H8Z70_RS12850	COG0583	DNA-binding transcription factor activity
H8Z70_RS12855	COG1741	Belongs to the pirin family
H8Z70_RS12870	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8Z70_RS12875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8Z70_RS12880	COG2137	regulation of response to DNA damage stimulus
H8Z70_RS12885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8Z70_RS12890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z70_RS12900	COG1546	Belongs to the CinA family
H8Z70_RS12905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8Z70_RS12915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8Z70_RS12920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8Z70_RS12930	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H8Z70_RS12935	COG1534	Rna-binding protein
H8Z70_RS12950	COG1238	metal cluster binding
H8Z70_RS12955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z70_RS12960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8Z70_RS12965	COG2840	Smr protein MutS2
H8Z70_RS12970	COG0585	pseudouridine synthase activity
H8Z70_RS12975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8Z70_RS12980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8Z70_RS12985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H8Z70_RS12990	COG0148	phosphopyruvate hydratase activity
H8Z70_RS13000	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8Z70_RS13005	COG0504	CTP synthase activity
H8Z70_RS13030	COG0306	phosphate transporter
H8Z70_RS13040	COG1253	flavin adenine dinucleotide binding
H8Z70_RS13055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z70_RS13060	COG0477	Major facilitator Superfamily
H8Z70_RS13070	COG1136	(ABC) transporter
H8Z70_RS13085	COG0438	transferase activity, transferring glycosyl groups
H8Z70_RS13095	COG2264	protein methyltransferase activity
H8Z70_RS13125	COG2244	polysaccharide biosynthetic process
H8Z70_RS13175	COG1595	DNA-templated transcription, initiation
H8Z70_RS13190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z70_RS13200	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z70_RS13210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z70_RS13225	COG4191	Histidine kinase
H8Z70_RS13225	COG0784	Response regulator, receiver
H8Z70_RS13230	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8Z70_RS13255	COG0840	transmembrane signaling receptor activity
H8Z70_RS13320	COG0583	DNA-binding transcription factor activity
H8Z70_RS13325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z70_RS13330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8Z70_RS13345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8Z70_RS13350	COG0077	Prephenate dehydratase
H8Z70_RS13350	COG1605	Chorismate mutase
H8Z70_RS13355	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H8Z70_RS13360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8Z70_RS13365	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H8Z70_RS13410	COG1228	amidohydrolase
H8Z70_RS13415	COG2986	histidine ammonia-lyase
H8Z70_RS13425	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H8Z70_RS13435	COG4993	Dehydrogenase
H8Z70_RS13445	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8Z70_RS13460	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H8Z70_RS13465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8Z70_RS13470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z70_RS13480	COG3115	cell septum assembly
H8Z70_RS13490	COG0359	binds to the 23S rRNA
H8Z70_RS13495	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8Z70_RS13500	COG0360	Binds together with S18 to 16S ribosomal RNA
H8Z70_RS13505	COG0316	Belongs to the HesB IscA family
H8Z70_RS13510	COG0017	Asparaginyl-tRNA synthetase
H8Z70_RS13530	COG2808	Putative FMN-binding domain
H8Z70_RS13595	COG0288	reversible hydration of carbon dioxide
H8Z70_RS13600	COG0662	Cupin 2, conserved barrel domain protein
H8Z70_RS13610	COG3844	kynureninase activity
H8Z70_RS13615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z70_RS13625	COG2925	Exonuclease
H8Z70_RS13650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8Z70_RS13655	COG0116	Belongs to the methyltransferase superfamily
H8Z70_RS13655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z70_RS13665	COG0488	(ABC) transporter
H8Z70_RS13700	COG0494	nUDIX hydrolase
H8Z70_RS13710	COG1024	Enoyl-CoA hydratase
H8Z70_RS13720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8Z70_RS13725	COG0659	secondary active sulfate transmembrane transporter activity
H8Z70_RS13750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8Z70_RS13755	COG0573	inorganic phosphate transmembrane transporter activity
H8Z70_RS13760	COG0581	inorganic phosphate transmembrane transporter activity
H8Z70_RS13765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8Z70_RS13770	COG0704	Plays a role in the regulation of phosphate uptake
H8Z70_RS13780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z70_RS13790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z70_RS13800	COG0557	exoribonuclease II activity
H8Z70_RS13815	COG1960	acyl-CoA dehydrogenase activity
H8Z70_RS13820	COG1960	acyl-CoA dehydrogenase activity
H8Z70_RS13825	COG1960	acyl-CoA dehydrogenase activity
H8Z70_RS13830	COG1960	acyl-CoA dehydrogenase activity
H8Z70_RS13835	COG2226	methyltransferase
H8Z70_RS13840	COG1410	methionine synthase
H8Z70_RS13840	COG0646	methionine synthase
H8Z70_RS13845	COG1410	methionine synthase
H8Z70_RS13845	COG0646	methionine synthase
H8Z70_RS13855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z70_RS13880	COG2900	Belongs to the SlyX family
H8Z70_RS13895	COG0386	Belongs to the glutathione peroxidase family
H8Z70_RS13905	COG1725	Transcriptional regulator
H8Z70_RS13910	COG1131	(ABC) transporter
H8Z70_RS13940	COG1253	flavin adenine dinucleotide binding
H8Z70_RS13960	COG2850	peptidyl-arginine hydroxylation
H8Z70_RS13995	COG1132	(ABC) transporter
H8Z70_RS14000	COG0583	DNA-binding transcription factor activity
H8Z70_RS14030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H8Z70_RS14040	COG0484	heat shock protein binding
H8Z70_RS14045	COG0443	Heat shock 70 kDa protein
H8Z70_RS14050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8Z70_RS14055	COG1420	regulation of RNA biosynthetic process
H8Z70_RS14060	COG0497	DNA recombination
H8Z70_RS14070	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z70_RS14085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8Z70_RS14110	COG3706	GGDEF domain
H8Z70_RS14155	COG0583	DNA-binding transcription factor activity
H8Z70_RS14165	COG0415	Belongs to the DNA photolyase family
H8Z70_RS14170	COG0305	Participates in initiation and elongation during chromosome replication
H8Z70_RS14180	COG0367	asparagine synthase
H8Z70_RS14195	COG1960	acyl-CoA dehydrogenase activity
H8Z70_RS14210	COG0084	hydrolase, TatD family'
H8Z70_RS14215	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8Z70_RS14270	COG0386	Belongs to the glutathione peroxidase family
H8Z70_RS14275	COG0339	signal peptide processing
H8Z70_RS14325	COG2814	Major facilitator Superfamily
H8Z70_RS14330	COG1566	PFAM secretion protein HlyD family protein
H8Z70_RS14360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z70_RS14375	COG4774	siderophore transport
H8Z70_RS14385	COG0367	asparagine synthase
H8Z70_RS14390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z70_RS14395	COG1393	Belongs to the ArsC family
H8Z70_RS14405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H8Z70_RS14445	COG0052	Belongs to the universal ribosomal protein uS2 family
H8Z70_RS14450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8Z70_RS14460	COG0528	UMP kinase activity
H8Z70_RS14465	COG0233	cytoplasmic translational termination
H8Z70_RS14470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8Z70_RS14475	COG0575	Belongs to the CDS family
H8Z70_RS14480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8Z70_RS14485	COG0750	zinc metalloprotease
H8Z70_RS14500	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z70_RS14505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z70_RS14510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z70_RS14515	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z70_RS14520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8Z70_RS14530	COG0825	malonyl-CoA metabolic process
H8Z70_RS14545	COG1981	membrane
H8Z70_RS14565	COG1695	Transcriptional regulator
H8Z70_RS14585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z70_RS14595	COG2040	homocysteine
H8Z70_RS14600	COG0833	amino acid
H8Z70_RS14605	COG0346	lactoylglutathione lyase activity
H8Z70_RS14610	COG1131	(ABC) transporter
H8Z70_RS14625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z70_RS14625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z70_RS14635	COG2878	Part of a membrane complex involved in electron transport
H8Z70_RS14650	COG1595	DNA-templated transcription, initiation
H8Z70_RS14675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z70_RS14690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z70_RS14695	COG0251	oxidation-reduction process
H8Z70_RS14705	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H8Z70_RS14705	COG0392	lysyltransferase activity
H8Z70_RS14740	COG2814	Major facilitator Superfamily
H8Z70_RS14745	COG1902	pentaerythritol trinitrate reductase activity
H8Z70_RS14750	COG2824	Alkylphosphonate utilization operon protein PhnA
H8Z70_RS14760	COG1047	Peptidyl-prolyl cis-trans
H8Z70_RS14765	COG1077	Cell shape determining protein MreB Mrl
H8Z70_RS14780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8Z70_RS14790	COG5487	UPF0391 membrane protein
H8Z70_RS14795	COG1451	nucleotide metabolic process
H8Z70_RS14820	COG0183	Belongs to the thiolase family
H8Z70_RS14850	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z70_RS14850	COG1793	dna ligase
H8Z70_RS14860	COG1793	dna ligase
H8Z70_RS14865	COG1201	RNA secondary structure unwinding
H8Z70_RS14875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z70_RS14880	COG1278	Cold shock
H8Z70_RS14885	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8Z70_RS14890	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H8Z70_RS14895	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z70_RS14900	COG3046	protein related to deoxyribodipyrimidine photolyase
H8Z70_RS14905	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H8Z70_RS14910	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H8Z70_RS14915	COG2954	triphosphatase activity
H8Z70_RS14920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z70_RS14930	COG1381	Involved in DNA repair and RecF pathway recombination
H8Z70_RS14935	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8Z70_RS14940	COG0571	ribonuclease III activity
H8Z70_RS14955	COG0481	GTPase activity
H8Z70_RS14960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z70_RS14975	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z70_RS14975	COG1024	Enoyl-CoA hydratase
H8Z70_RS14995	COG1024	Enoyl-CoA hydratase
H8Z70_RS15000	COG1960	acyl-CoA dehydrogenase activity
H8Z70_RS15020	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H8Z70_RS15025	COG3250	beta-galactosidase activity
H8Z70_RS15045	COG3209	COG3209 Rhs family protein
H8Z70_RS15055	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8Z70_RS15065	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H8Z70_RS15085	COG0534	Mate efflux family protein
H8Z70_RS15090	COG0335	large ribosomal subunit rRNA binding
H8Z70_RS15095	COG0336	Belongs to the RNA methyltransferase TrmD family
H8Z70_RS15100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8Z70_RS15105	COG0228	four-way junction DNA binding
H8Z70_RS15110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z70_RS15120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8Z70_RS15125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z70_RS15155	COG4191	Histidine kinase
H8Z70_RS15155	COG0784	Response regulator, receiver
H8Z70_RS15160	COG2205	protein histidine kinase activity
H8Z70_RS15160	COG3850	Histidine kinase
H8Z70_RS15160	COG4999	Histidine kinase
H8Z70_RS15160	COG3437	response regulator, receiver
H8Z70_RS15165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z70_RS15175	COG2205	protein histidine kinase activity
H8Z70_RS15180	COG5507	3-demethylubiquinone-9 3-methyltransferase
H8Z70_RS15190	COG4771	TonB-dependent receptor
H8Z70_RS15215	COG2172	sigma factor antagonist activity
H8Z70_RS15220	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z70_RS15225	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z70_RS15235	COG0326	Molecular chaperone. Has ATPase activity
H8Z70_RS15240	COG2207	Transcriptional regulator
H8Z70_RS15250	COG3152	Membrane
H8Z70_RS15265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8Z70_RS15270	COG1845	cytochrome c oxidase, subunit III
H8Z70_RS15275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8Z70_RS15290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8Z70_RS15295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8Z70_RS15300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8Z70_RS15305	COG0196	riboflavin kinase activity
H8Z70_RS15315	COG0268	Binds directly to 16S ribosomal RNA
H8Z70_RS15320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8Z70_RS15325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8Z70_RS15330	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8Z70_RS15335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8Z70_RS15340	COG0824	Thioesterase
H8Z70_RS15355	COG1946	Acyl-CoA thioesterase
H8Z70_RS15375	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H8Z70_RS15385	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8Z70_RS15410	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8Z70_RS15425	COG2197	response regulator
H8Z70_RS15430	COG4585	Histidine kinase
H8Z70_RS15440	COG0850	regulation of cytokinetic process
H8Z70_RS15445	COG2894	cell division
H8Z70_RS15450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8Z70_RS15460	COG0642	Histidine kinase
H8Z70_RS15465	COG0745	RESPONSE REGULATOR receiver
H8Z70_RS15480	COG2194	sulfuric ester hydrolase activity
H8Z70_RS15495	COG2814	Major facilitator Superfamily
H8Z70_RS15500	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z70_RS15500	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z70_RS15510	COG0656	L-ascorbic acid biosynthetic process
H8Z70_RS15515	COG0753	catalase activity
H8Z70_RS15530	COG2207	Transcriptional regulator
H8Z70_RS15530	COG1917	Cupin 2, conserved barrel domain protein
H8Z70_RS15545	COG0823	Involved in the tonB-independent uptake of proteins
H8Z70_RS15545	COG1506	peptidase
H8Z70_RS15560	COG1297	OPT oligopeptide transporter protein
H8Z70_RS15580	COG0587	DNA-directed DNA polymerase activity
H8Z70_RS15595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z70_RS15630	COG2080	2 iron, 2 sulfur cluster binding
H8Z70_RS15635	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z70_RS15640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z70_RS15665	COG0492	ferredoxin-NADP+ reductase activity
H8Z70_RS15685	COG3537	Alpha-1,2-mannosidase
H8Z70_RS15690	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS15695	COG3387	PFAM Glycoside hydrolase 15-related
H8Z70_RS15705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z70_RS15735	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H8Z70_RS15780	COG1309	transcriptional regulator
H8Z70_RS15785	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS15790	COG0308	aminopeptidase N
H8Z70_RS15795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8Z70_RS15805	COG0330	HflC and HflK could
H8Z70_RS15810	COG0330	HflC and HflK could
H8Z70_RS15830	COG0678	peroxiredoxin activity
H8Z70_RS15840	COG4953	penicillin-binding protein 1C
H8Z70_RS15855	COG2373	Large extracellular alpha-helical protein
H8Z70_RS15885	COG3609	addiction module antidote protein, CC2985 family
H8Z70_RS15905	COG3829	transcription factor binding
H8Z70_RS15930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8Z70_RS15935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8Z70_RS15950	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS15965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z70_RS15970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8Z70_RS15975	COG1399	metal-binding, possibly nucleic acid-binding protein
H8Z70_RS15980	COG0424	maF-like protein
H8Z70_RS16000	COG0714	Associated with various cellular activities
H8Z70_RS16020	COG0537	adenosine 5'-monophosphoramidase activity
H8Z70_RS16025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8Z70_RS16030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8Z70_RS16075	COG0210	DNA helicase
H8Z70_RS16145	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H8Z70_RS16165	COG2003	Belongs to the UPF0758 family
H8Z70_RS16245	COG0314	molybdopterin synthase activity
H8Z70_RS16250	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8Z70_RS16255	COG0315	cyclic pyranopterin monophosphate synthase activity
H8Z70_RS16265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8Z70_RS16270	COG1234	tRNA 3'-trailer cleavage
H8Z70_RS16275	COG3642	lipopolysaccharide core region biosynthetic process
H8Z70_RS16280	COG0859	PFAM glycosyl transferase family 9
H8Z70_RS16295	COG0631	protein serine/threonine phosphatase activity
H8Z70_RS16300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z70_RS16305	COG0328	RNA-DNA hybrid ribonuclease activity
H8Z70_RS16315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z70_RS16325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z70_RS16355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8Z70_RS16365	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8Z70_RS16520	COG0473	3-isopropylmalate dehydrogenase activity
H8Z70_RS16535	COG4783	chaperone-mediated protein folding
H8Z70_RS16550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8Z70_RS16560	COG0438	transferase activity, transferring glycosyl groups
H8Z70_RS16565	COG0671	phosphoesterase, PA-phosphatase related
H8Z70_RS16570	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z70_RS16580	COG3291	Pkd domain containing protein
H8Z70_RS16590	COG2833	Protein of unknown function (DUF455)
H8Z70_RS16610	COG0285	dihydrofolate synthase activity
H8Z70_RS16615	COG0406	alpha-ribazole phosphatase activity
H8Z70_RS16645	COG1063	alcohol dehydrogenase
H8Z70_RS16655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H8Z70_RS16660	COG4208	sulfate ABC transporter
H8Z70_RS16665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H8Z70_RS16670	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H8Z70_RS16675	COG0156	8-amino-7-oxononanoate synthase activity
H8Z70_RS16700	COG0604	alcohol dehydrogenase
H8Z70_RS16705	COG1902	pentaerythritol trinitrate reductase activity
H8Z70_RS16705	COG0446	pyridine nucleotide-disulphide oxidoreductase
H8Z70_RS16715	COG0625	glutathione transferase activity
H8Z70_RS16720	COG0039	L-malate dehydrogenase activity
H8Z70_RS16725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8Z70_RS16730	COG1217	gtp-binding protein TYPA
H8Z70_RS16740	COG0154	amidase activity
H8Z70_RS16750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H8Z70_RS16765	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H8Z70_RS16770	COG0203	ribosomal protein L17
H8Z70_RS16795	COG0201	protein transport
H8Z70_RS16800	COG0200	Binds to the 23S rRNA
H8Z70_RS16805	COG1841	ribosomal large subunit assembly
H8Z70_RS16815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8Z70_RS16820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8Z70_RS16825	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8Z70_RS16835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8Z70_RS16840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8Z70_RS16850	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8Z70_RS16855	COG0255	Belongs to the universal ribosomal protein uL29 family
H8Z70_RS16860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8Z70_RS16865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8Z70_RS16875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8Z70_RS16880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8Z70_RS16885	COG0089	rRNA binding
H8Z70_RS16890	COG0088	Forms part of the polypeptide exit tunnel
H8Z70_RS16895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8Z70_RS16900	COG0051	transcription antitermination factor activity, RNA binding
H8Z70_RS16905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z70_RS16910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8Z70_RS16915	COG0049	tRNA binding
H8Z70_RS16920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8Z70_RS16925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8Z70_RS16930	COG0085	RNA polymerase activity
H8Z70_RS16935	COG0222	ribosome binding
H8Z70_RS16940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8Z70_RS16945	COG0081	regulation of translation
H8Z70_RS16950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8Z70_RS16955	COG0250	Participates in transcription elongation, termination and antitermination
H8Z70_RS16970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z70_RS16990	COG0012	GTP binding
H8Z70_RS16995	COG0193	aminoacyl-tRNA hydrolase activity
H8Z70_RS17000	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H8Z70_RS17005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8Z70_RS17015	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8Z70_RS17020	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H8Z70_RS17030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8Z70_RS17035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8Z70_RS17045	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8Z70_RS17060	COG1254	Belongs to the acylphosphatase family
H8Z70_RS17065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z70_RS17070	COG1295	ribonuclease BN
H8Z70_RS17095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8Z70_RS17100	COG1404	Belongs to the peptidase S8 family
H8Z70_RS17105	COG1404	Belongs to the peptidase S8 family
H8Z70_RS17110	COG1404	Belongs to the peptidase S8 family
H8Z70_RS17115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z70_RS17130	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H8Z70_RS17155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8Z70_RS17185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z70_RS17185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z70_RS17205	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z70_RS17215	COG3634	alkyl hydroperoxide reductase activity
H8Z70_RS17220	COG0583	DNA-binding transcription factor activity
H8Z70_RS17225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z70_RS17230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8Z70_RS17240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8Z70_RS17250	COG2197	response regulator
H8Z70_RS17255	COG5002	protein histidine kinase activity
H8Z70_RS17255	COG2205	protein histidine kinase activity
H8Z70_RS17255	COG0784	Response regulator, receiver
H8Z70_RS17275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z70_RS17280	COG0697	spore germination
H8Z70_RS17305	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H8Z70_RS17320	COG3386	PFAM SMP-30 Gluconolaconase
H8Z70_RS17340	COG1024	Enoyl-CoA hydratase
H8Z70_RS17355	COG0583	DNA-binding transcription factor activity
H8Z70_RS17360	COG3384	dioxygenase
H8Z70_RS17390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z70_RS17395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z70_RS17410	COG2096	Adenosyltransferase
H8Z70_RS17415	COG0123	including yeast histone deacetylase and acetoin utilization protein
H8Z70_RS17430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H8Z70_RS17435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z70_RS17440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8Z70_RS17445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8Z70_RS17450	COG2967	ApaG domain
H8Z70_RS17455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8Z70_RS17475	COG0747	negative chemotaxis
H8Z70_RS17500	COG0431	NADPH-dependent FMN reductase
H8Z70_RS17505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z70_RS17515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z70_RS17520	COG1116	anion transmembrane transporter activity
H8Z70_RS17530	COG3829	transcription factor binding
H8Z70_RS17545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H8Z70_RS17550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8Z70_RS17570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8Z70_RS17580	COG0642	Histidine kinase
H8Z70_RS17595	COG4181	ATPase activity
H8Z70_RS17605	COG2175	clavaminate synthase activity
H8Z70_RS17615	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H8Z70_RS17620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z70_RS17640	COG4771	TonB-dependent receptor
H8Z70_RS17650	COG0667	Aldo Keto reductase
H8Z70_RS17655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8Z70_RS17660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z70_RS17670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z70_RS17675	COG4106	trans-aconitate 2-methyltransferase activity
H8Z70_RS17685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8Z70_RS17725	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8Z70_RS17735	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H8Z70_RS17740	COG2226	methyltransferase
H8Z70_RS17765	COG0366	Alpha amylase catalytic
H8Z70_RS17780	COG3321	synthase
H8Z70_RS17780	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS17780	COG0604	alcohol dehydrogenase
H8Z70_RS17800	COG0494	nUDIX hydrolase
H8Z70_RS17805	COG0653	protein targeting
H8Z70_RS17810	COG0739	heme binding
H8Z70_RS17820	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8Z70_RS17835	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H8Z70_RS17840	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z70_RS17845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z70_RS17850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8Z70_RS17860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z70_RS17865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8Z70_RS17870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8Z70_RS17880	COG3116	cell division
H8Z70_RS17885	COG0275	rRNA processing
H8Z70_RS17920	COG0792	nuclease activity
H8Z70_RS17925	COG1988	membrane-bound metal-dependent
H8Z70_RS17930	COG0277	FAD linked oxidase domain protein
H8Z70_RS17950	COG0745	RESPONSE REGULATOR receiver
H8Z70_RS17955	COG2205	protein histidine kinase activity
H8Z70_RS17960	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H8Z70_RS17965	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H8Z70_RS17970	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H8Z70_RS17990	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8Z70_RS17995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z70_RS18000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8Z70_RS18020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z70_RS18020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z70_RS18030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8Z70_RS18035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8Z70_RS18045	COG0488	(ABC) transporter
H8Z70_RS18055	COG0697	spore germination
H8Z70_RS18065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z70_RS18080	COG3791	Glutathione-dependent formaldehyde-activating
H8Z70_RS18110	COG2205	protein histidine kinase activity
H8Z70_RS18125	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z70_RS18130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H8Z70_RS18145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z70_RS18160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8Z70_RS18165	COG1012	belongs to the aldehyde dehydrogenase family
H8Z70_RS18170	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H8Z70_RS18175	COG0617	tRNA 3'-terminal CCA addition
H8Z70_RS18185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8Z70_RS18190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z70_RS18195	COG1609	Transcriptional regulator
H8Z70_RS18205	COG2188	Transcriptional regulator
H8Z70_RS18220	COG3250	beta-galactosidase activity
H8Z70_RS18270	COG1459	type II secretion system
H8Z70_RS18325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8Z70_RS18330	COG4191	Histidine kinase
H8Z70_RS18335	COG0784	Response regulator, receiver
H8Z70_RS18340	COG4251	negative regulation of phosphorylation
H8Z70_RS18345	COG2823	Periplasmic or secreted lipoprotein
H8Z70_RS18355	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H8Z70_RS18390	COG1056	cytidyltransferase-related domain
H8Z70_RS18390	COG1051	belongs to the nudix hydrolase family
H8Z70_RS18400	COG0583	DNA-binding transcription factor activity
H8Z70_RS18415	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8Z70_RS18420	COG0321	lipoyl(octanoyl) transferase activity
H8Z70_RS18425	COG2921	Belongs to the UPF0250 family
H8Z70_RS18435	COG1686	Belongs to the peptidase S11 family
H8Z70_RS18440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8Z70_RS18445	COG2951	lytic endotransglycosylase activity
H8Z70_RS18455	COG0772	Belongs to the SEDS family
H8Z70_RS18470	COG1792	Involved in formation and maintenance of cell shape
H8Z70_RS18475	COG1077	Cell shape determining protein MreB Mrl
H8Z70_RS18480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z70_RS18485	COG3284	Transcriptional regulator
H8Z70_RS18530	COG0308	aminopeptidase N
H8Z70_RS18535	COG5001	Diguanylate cyclase
H8Z70_RS18535	COG3300	MHYT domain
H8Z70_RS18540	COG2226	methyltransferase
H8Z70_RS18565	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H8Z70_RS18570	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H8Z70_RS18575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H8Z70_RS18585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8Z70_RS18595	COG2832	Protein of unknown function (DUF454)
H8Z70_RS18605	COG0436	Aminotransferase
H8Z70_RS18610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8Z70_RS18615	COG1505	serine-type exopeptidase activity
H8Z70_RS18640	COG0181	hydroxymethylbilane synthase activity
H8Z70_RS18650	COG3275	phosphorelay sensor kinase activity
H8Z70_RS18660	COG2943	transferase activity, transferring hexosyl groups
H8Z70_RS18675	COG0659	secondary active sulfate transmembrane transporter activity
H8Z70_RS18680	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z70_RS18680	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z70_RS18685	COG0840	transmembrane signaling receptor activity
H8Z70_RS18690	COG5001	Diguanylate cyclase
H8Z70_RS18725	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H8Z70_RS18745	COG1113	amino acid transport
H8Z70_RS18760	COG0697	spore germination
H8Z70_RS18800	COG1506	peptidase
H8Z70_RS18800	COG0823	Involved in the tonB-independent uptake of proteins
H8Z70_RS18805	COG2409	Drug exporters of the RND superfamily
H8Z70_RS18830	COG0435	Glutathione S-transferase
H8Z70_RS18840	COG4221	oxidoreductase activity
H8Z70_RS18855	COG4221	oxidoreductase activity
H8Z70_RS18910	COG1802	Transcriptional regulator
H8Z70_RS18920	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8Z70_RS18945	COG3052	prosthetic group binding
H8Z70_RS18975	COG2353	YceI-like domain
H8Z70_RS18980	COG0778	Nitroreductase
H8Z70_RS18995	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z70_RS19000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H8Z70_RS19010	COG3386	PFAM SMP-30 Gluconolaconase
H8Z70_RS19025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8Z70_RS19040	COG0459	protein refolding
H8Z70_RS19055	COG2356	endonuclease I
H8Z70_RS19060	COG0300	oxidoreductase activity
H8Z70_RS19085	COG1324	tolerance protein
H8Z70_RS19095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8Z70_RS19100	COG0511	ligase activity, forming carbon-carbon bonds
H8Z70_RS19110	COG0439	Biotin carboxylase
H8Z70_RS19125	COG2264	protein methyltransferase activity
H8Z70_RS19145	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H8Z70_RS19150	COG4589	Belongs to the CDS family
H8Z70_RS19175	COG0671	phosphoesterase, PA-phosphatase related
H8Z70_RS19175	COG2453	phosphatase
H8Z70_RS19180	COG2267	carboxylic ester hydrolase activity
H8Z70_RS19185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z70_RS19190	COG0138	bifunctional purine biosynthesis protein purh
H8Z70_RS19200	COG0151	Belongs to the GarS family
H8Z70_RS19210	COG1289	transmembrane transporter activity
H8Z70_RS19215	COG2814	Major facilitator Superfamily
H8Z70_RS19220	COG0583	DNA-binding transcription factor activity
H8Z70_RS19225	COG2814	Major facilitator Superfamily
H8Z70_RS19240	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z70_RS19255	COG0316	Belongs to the HesB IscA family
H8Z70_RS19295	COG1051	belongs to the nudix hydrolase family
H8Z70_RS19310	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8Z70_RS19320	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H8Z70_RS19330	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8Z70_RS19335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z70_RS19345	COG0134	indole-3-glycerol-phosphate synthase activity
H8Z70_RS19350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8Z70_RS19375	COG1597	lipid kinase activity
H8Z70_RS19380	COG0456	acetyltransferase
H8Z70_RS19395	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H8Z70_RS19400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8Z70_RS19420	COG3179	chitinase
H8Z70_RS19440	COG2111	Na H antiporter
H8Z70_RS19440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z70_RS19445	COG1006	Multisubunit Na H antiporter MnhC subunit
H8Z70_RS19450	COG0651	ATP synthesis coupled electron transport
H8Z70_RS19460	COG2212	antiporter activity
H8Z70_RS19465	COG1320	monovalent cation:proton antiporter activity
H8Z70_RS19480	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H8Z70_RS19505	COG3104	oligopeptide transport
H8Z70_RS19510	COG3483	tryptophan 2,3-dioxygenase activity
H8Z70_RS19520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8Z70_RS19535	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8Z70_RS19545	COG0513	Belongs to the DEAD box helicase family
H8Z70_RS19555	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS19560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z70_RS19590	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS19595	COG0702	epimerase
H8Z70_RS19620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z70_RS19625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z70_RS19630	COG0297	glycogen (starch) synthase activity
H8Z70_RS19640	COG2354	Protein conserved in bacteria
H8Z70_RS19645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z70_RS19650	COG1368	sulfuric ester hydrolase activity
H8Z70_RS19655	COG3264	Mechanosensitive ion channel
H8Z70_RS19655	COG1511	domain protein
H8Z70_RS19725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z70_RS19805	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z70_RS19810	COG1040	competence protein
H8Z70_RS19815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8Z70_RS19820	COG0156	8-amino-7-oxononanoate synthase activity
H8Z70_RS19830	COG2267	carboxylic ester hydrolase activity
H8Z70_RS19860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8Z70_RS19870	COG0445	tRNA wobble uridine modification
H8Z70_RS19880	COG0657	acetylesterase activity
H8Z70_RS19890	COG1414	Transcriptional regulator
H8Z70_RS19900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8Z70_RS19905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z70_RS19915	COG3485	protocatechuate 3,4-dioxygenase
H8Z70_RS19920	COG3485	protocatechuate 3,4-dioxygenase
H8Z70_RS19930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H8Z70_RS19935	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8Z70_RS19960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8Z70_RS19965	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8Z70_RS20025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8Z70_RS20040	COG0129	dihydroxy-acid dehydratase activity
H8Z70_RS20070	COG1733	regulation of RNA biosynthetic process
H8Z70_RS20075	COG0702	epimerase
H8Z70_RS20105	COG0583	DNA-binding transcription factor activity
H8Z70_RS20110	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z70_RS20115	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z70_RS20135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z70_RS20140	COG2205	protein histidine kinase activity
H8Z70_RS20145	COG0745	RESPONSE REGULATOR receiver
H8Z70_RS20165	COG1902	pentaerythritol trinitrate reductase activity
H8Z70_RS20170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8Z70_RS20185	COG2814	Major facilitator Superfamily
H8Z70_RS20190	COG0583	DNA-binding transcription factor activity
H8Z70_RS20205	COG0084	hydrolase, TatD family'
H8Z70_RS20225	COG2252	PERMEase
H8Z70_RS20235	COG1957	nucleoside hydrolase
H8Z70_RS20270	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8Z70_RS20290	COG2072	flavoprotein involved in K transport
H8Z70_RS20295	COG2351	hydroxyisourate hydrolase activity
H8Z70_RS20300	COG4807	Protein conserved in bacteria
H8Z70_RS20305	COG1643	Atp-dependent helicase
H8Z70_RS20320	COG1187	pseudouridine synthase activity
H8Z70_RS20335	COG2130	NADP-dependent
H8Z70_RS20360	COG1764	response to oxidative stress
H8Z70_RS20365	COG1846	Transcriptional regulator
H8Z70_RS20370	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H8Z70_RS20380	COG0697	spore germination
H8Z70_RS20390	COG0523	cobalamin synthesis protein
H8Z70_RS20445	COG1960	acyl-CoA dehydrogenase activity
H8Z70_RS20450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H8Z70_RS20455	COG4770	biotin carboxylase activity
H8Z70_RS20485	COG2224	Isocitrate lyase
H8Z70_RS20490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H8Z70_RS20495	COG0583	DNA-binding transcription factor activity
H8Z70_RS20500	COG0475	glutathione-regulated potassium exporter activity
H8Z70_RS20530	COG0339	signal peptide processing
H8Z70_RS20565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z70_RS20575	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z70_RS20585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z70_RS20590	COG0318	PFAM AMP-dependent synthetase and ligase
H8Z70_RS20595	COG0727	PFAM Uncharacterised protein family (UPF0153)
H8Z70_RS20600	COG0596	Alpha beta hydrolase
H8Z70_RS20610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z70_RS20625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8Z70_RS20650	COG2205	protein histidine kinase activity
H8Z70_RS20655	COG0028	Belongs to the TPP enzyme family
H8Z70_RS20670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8Z70_RS20675	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H8Z70_RS20680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8Z70_RS20715	COG0183	Belongs to the thiolase family
H8Z70_RS20725	COG0346	lactoylglutathione lyase activity
H8Z70_RS20735	COG2032	superoxide dismutase activity
H8Z70_RS20740	COG2032	superoxide dismutase activity
H8Z70_RS20745	COG2204	response regulator
H8Z70_RS20750	COG3852	Histidine kinase
H8Z70_RS20755	COG0004	ammonium transporteR
H8Z70_RS20760	COG0347	Belongs to the P(II) protein family
H8Z70_RS20765	COG0174	glutamine synthetase
H8Z70_RS20770	COG1968	undecaprenyl-diphosphatase activity
H8Z70_RS20815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z70_RS20825	COG2062	phosphohistidine phosphatase, SixA
H8Z70_RS20830	COG0489	protein tyrosine kinase activity
H8Z70_RS20850	COG1396	sequence-specific DNA binding
H8Z70_RS20870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z70_RS20885	COG1125	glycine betaine transport
H8Z70_RS20950	COG3237	CsbD-like
H8Z70_RS20995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z70_RS21000	COG0477	Major facilitator Superfamily
H8Z70_RS21040	COG0714	Associated with various cellular activities
H8Z70_RS21075	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H8Z70_RS21085	COG4772	TonB-dependent receptor
H8Z70_RS21095	COG0662	Cupin 2, conserved barrel domain protein
H8Z70_RS21100	COG1012	belongs to the aldehyde dehydrogenase family
H8Z70_RS21125	COG1304	FMN binding
H8Z70_RS21135	COG4585	Histidine kinase
H8Z70_RS21140	COG2197	response regulator
H8Z70_RS21160	COG3710	Transcriptional regulator
H8Z70_RS21165	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8Z70_RS21280	COG0210	DNA helicase
H8Z70_RS21290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z70_RS21295	COG0583	DNA-binding transcription factor activity
H8Z70_RS21300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z70_RS21310	COG2159	amidohydrolase
H8Z70_RS21330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z70_RS21350	COG0357	Ribosomal RNA small subunit methyltransferase G
H8Z70_RS21355	COG3540	Alkaline phosphatase
H8Z70_RS21365	COG2091	lysine biosynthetic process via aminoadipic acid
H8Z70_RS21380	COG0708	Exodeoxyribonuclease III
H8Z70_RS21385	COG1940	carbohydrate kinase activity
H8Z70_RS21385	COG1846	Transcriptional regulator
H8Z70_RS21395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z70_RS21405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8Z70_RS21410	COG3162	membrane
H8Z70_RS21420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8Z70_RS21445	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z70_RS21465	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z70_RS21470	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8Z70_RS21475	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z70_RS21480	COG3254	rhamnose metabolic process
H8Z70_RS21485	COG0738	Major facilitator superfamily
H8Z70_RS21490	COG1414	Transcriptional regulator
H8Z70_RS21495	COG1971	Probably functions as a manganese efflux pump
H8Z70_RS21500	COG2205	protein histidine kinase activity
H8Z70_RS21510	COG3459	Glycosyltransferase 36 associated
H8Z70_RS21515	COG2211	Major facilitator Superfamily
H8Z70_RS21520	COG3265	gluconokinase activity
H8Z70_RS21525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z70_RS21545	COG2911	Protein conserved in bacteria
H8Z70_RS21550	COG0729	surface antigen
H8Z70_RS21600	COG0752	glycyl-tRNA synthetase alpha subunit
H8Z70_RS21605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z70_RS21615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z70_RS21615	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z70_RS21625	COG0805	protein transport
H8Z70_RS21630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z70_RS21635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z70_RS21645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8Z70_RS21665	COG2974	May be involved in recombination
H8Z70_RS21670	COG0037	tRNA processing
H8Z70_RS21675	COG2115	Belongs to the xylose isomerase family
H8Z70_RS21685	COG3661	Belongs to the glycosyl hydrolase 67 family
H8Z70_RS21695	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z70_RS21705	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z70_RS21710	COG0246	Mannitol dehydrogenase
H8Z70_RS21755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z70_RS21785	COG3386	PFAM SMP-30 Gluconolaconase
H8Z70_RS21795	COG3250	beta-galactosidase activity
H8Z70_RS21800	COG1904	glucuronate isomerase
H8Z70_RS21805	COG3693	PFAM glycoside hydrolase, family 10
H8Z70_RS21815	COG3693	PFAM glycoside hydrolase, family 10
H8Z70_RS21830	COG2211	Major facilitator Superfamily
H8Z70_RS21900	COG2937	Belongs to the GPAT DAPAT family
H8Z70_RS21930	COG0284	orotidine-5'-phosphate decarboxylase activity
H8Z70_RS21935	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H8Z70_RS21940	COG3132	Protein of unknown function, DUF480
H8Z70_RS21955	COG0210	DNA helicase
H8Z70_RS21960	COG1435	thymidine kinase activity
H8Z70_RS21970	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H8Z70_RS21980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8Z70_RS22010	COG3135	benzoate transporter
H8Z70_RS22030	COG0676	glucose-6-phosphate 1-epimerase activity
H8Z70_RS22040	COG3012	SEC-C Motif Domain Protein
H8Z70_RS22045	COG0730	response to heat
H8Z70_RS22065	COG0302	gtp cyclohydrolase
H8Z70_RS22080	COG1566	PFAM secretion protein HlyD family protein
H8Z70_RS22090	COG1289	transmembrane transporter activity
H8Z70_RS22095	COG0477	Major facilitator Superfamily
H8Z70_RS22105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z70_RS22125	COG4691	Plasmid stability protein
H8Z70_RS22130	COG1487	ribonuclease activity
H8Z70_RS22165	COG0564	pseudouridine synthase activity
H8Z70_RS22195	COG0439	Biotin carboxylase
H8Z70_RS22240	COG1074	ATP-dependent DNA helicase activity
H8Z70_RS22245	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H8Z70_RS22260	COG1127	ABC transporter
H8Z70_RS22265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z70_RS22270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z70_RS22285	COG2853	Lipoprotein
H8Z70_RS22295	COG0386	Belongs to the glutathione peroxidase family
H8Z70_RS22305	COG1322	Protein conserved in bacteria
H8Z70_RS22310	COG0604	alcohol dehydrogenase
H8Z70_RS22325	COG0625	glutathione transferase activity
H8Z70_RS22335	COG0531	amino acid
H8Z70_RS22340	COG3537	Alpha-1,2-mannosidase
H8Z70_RS22350	COG3706	GGDEF domain
H8Z70_RS22355	COG3835	regulator
H8Z70_RS22360	COG1929	Belongs to the glycerate kinase type-1 family
H8Z70_RS22365	COG2271	Major facilitator Superfamily
H8Z70_RS22380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z70_RS22385	COG0861	Integral membrane protein TerC family
H8Z70_RS22395	COG0584	glycerophosphoryl diester phosphodiesterase
H8Z70_RS22410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8Z70_RS22415	COG0726	polysaccharide deacetylase
H8Z70_RS22420	COG0706	membrane insertase activity
H8Z70_RS22425	COG0594	ribonuclease P activity
H8Z70_RS22520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z70_RS22540	COG3012	SEC-C Motif Domain Protein
H8Z70_RS22540	COG3318	Belongs to the UPF0149 family
H8Z70_RS22560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z70_RS22565	COG4456	Virulence-associated protein
H8Z70_RS22645	COG2948	multi-organism process
H8Z70_RS22650	COG3504	Conjugal transfer protein
H8Z70_RS22660	COG3704	protein secretion by the type IV secretion system
H8Z70_RS22780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z70_RS22815	COG3846	protein secretion by the type IV secretion system
H8Z70_RS22835	COG3451	type IV secretory pathway VirB4
H8Z70_RS22850	COG4962	Type ii secretion system protein e
H8Z70_RS22920	COG0489	protein tyrosine kinase activity
H8Z70_RS23000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8Z70_RS23110	COG3704	protein secretion by the type IV secretion system
H8Z70_RS23120	COG3504	Conjugal transfer protein
H8Z70_RS23125	COG2948	multi-organism process
H8Z70_RS23145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z70_RS23215	COG3041	Addiction module toxin RelE StbE family
H8Z70_RS23220	COG3077	Addiction module antitoxin, RelB DinJ family
H8Z70_RS23300	COG1192	Involved in chromosome partitioning
H8Z70_RS23345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z70_RS23365	COG3318	Belongs to the UPF0149 family
H8Z70_RS23365	COG3012	SEC-C Motif Domain Protein