locus-tag	class	description
BI315_RS00015	COG3279	Response regulator of the LytR AlgR family
BI315_RS00020	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BI315_RS00025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BI315_RS00035	COG0784	Response regulator, receiver
BI315_RS00035	COG2198	Histidine kinase
BI315_RS00035	COG2205	protein histidine kinase activity
BI315_RS00040	COG1024	Enoyl-CoA hydratase
BI315_RS00045	COG0318	PFAM AMP-dependent synthetase and ligase
BI315_RS00075	COG2267	carboxylic ester hydrolase activity
BI315_RS00085	COG2201	protein-glutamate methylesterase activity
BI315_RS00090	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BI315_RS00100	COG0840	transmembrane signaling receptor activity
BI315_RS00110	COG0835	chemotaxis
BI315_RS00125	COG0840	transmembrane signaling receptor activity
BI315_RS00130	COG0840	transmembrane signaling receptor activity
BI315_RS00145	COG0840	transmembrane signaling receptor activity
BI315_RS00155	COG0840	transmembrane signaling receptor activity
BI315_RS00160	COG0840	transmembrane signaling receptor activity
BI315_RS00165	COG0840	transmembrane signaling receptor activity
BI315_RS00170	COG0840	transmembrane signaling receptor activity
BI315_RS00185	COG0840	transmembrane signaling receptor activity
BI315_RS00205	COG0643	Histidine kinase
BI315_RS00205	COG2198	Histidine kinase
BI315_RS00210	COG0745	RESPONSE REGULATOR receiver
BI315_RS00230	COG1360	Flagellar Motor Protein
BI315_RS00235	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BI315_RS00310	COG3002	Belongs to the UPF0753 family
BI315_RS00350	COG0641	radical SAM
BI315_RS00370	COG0643	Histidine kinase
BI315_RS00370	COG0784	Response regulator, receiver
BI315_RS00370	COG2198	Histidine kinase
BI315_RS00400	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI315_RS00430	COG1684	flagellar biosynthetic protein fliR
BI315_RS00450	COG3190	flagellar
BI315_RS00500	COG1677	Flagellar hook-basal body complex protein FliE
BI315_RS00530	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS00535	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS00540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI315_RS00560	COG2201	protein-glutamate methylesterase activity
BI315_RS00590	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BI315_RS00595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI315_RS00600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI315_RS00610	COG1705	Flagellar rod assembly protein muramidase FlgJ
BI315_RS00610	COG3951	Flagellar rod assembly protein muramidase FlgJ
BI315_RS00615	COG1706	bacterial-type flagellum-dependent cell motility
BI315_RS00620	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BI315_RS00635	COG4787	bacterial-type flagellum-dependent cell motility
BI315_RS00645	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BI315_RS00650	COG1558	bacterial-type flagellum-dependent cell motility
BI315_RS00660	COG0784	Response regulator, receiver
BI315_RS00660	COG0835	chemotaxis
BI315_RS00685	COG5002	protein histidine kinase activity
BI315_RS00715	COG2915	High frequency lysogenization protein hflD homolog
BI315_RS00720	COG0482	sulfurtransferase activity
BI315_RS00735	COG0542	response to heat
BI315_RS00745	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BI315_RS00755	COG0492	ferredoxin-NADP+ reductase activity
BI315_RS00760	COG1674	ftsk spoiiie
BI315_RS00770	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BI315_RS00780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BI315_RS00785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BI315_RS00795	COG0183	Belongs to the thiolase family
BI315_RS00800	COG1024	Enoyl-CoA hydratase
BI315_RS00800	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI315_RS00815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BI315_RS00825	COG1426	Protein conserved in bacteria
BI315_RS00835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI315_RS00840	COG1160	GTP binding
BI315_RS00845	COG0303	'Molybdopterin
BI315_RS00850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI315_RS00890	COG0708	Exodeoxyribonuclease III
BI315_RS00900	COG0303	'Molybdopterin
BI315_RS00905	COG0746	molybdenum cofactor guanylyltransferase activity
BI315_RS00920	COG1914	H( )-stimulated, divalent metal cation uptake system
BI315_RS00935	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BI315_RS00940	COG0668	transmembrane transport
BI315_RS00950	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BI315_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS00970	COG1183	phosphatidylcholine synthase activity
BI315_RS00980	COG3243	poly(R)-hydroxyalkanoic acid synthase
BI315_RS00995	COG0723	plastoquinol--plastocyanin reductase activity
BI315_RS00995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI315_RS01005	COG2183	response to ionizing radiation
BI315_RS01010	COG0784	Response regulator, receiver
BI315_RS01010	COG2205	protein histidine kinase activity
BI315_RS01090	COG0800	Aldolase
BI315_RS01095	COG0129	dihydroxy-acid dehydratase activity
BI315_RS01100	COG0363	glucosamine-6-phosphate deaminase activity
BI315_RS01105	COG0837	glucose binding
BI315_RS01110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI315_RS01135	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BI315_RS01150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BI315_RS01155	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BI315_RS01165	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI315_RS01170	COG1136	(ABC) transporter
BI315_RS01185	COG0811	peptide transport
BI315_RS01195	COG1132	(ABC) transporter
BI315_RS01200	COG1663	tetraacyldisaccharide 4'-kinase activity
BI315_RS01205	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BI315_RS01210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI315_RS01220	COG0322	excinuclease ABC activity
BI315_RS01225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BI315_RS01250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI315_RS01280	COG2801	Transposase and inactivated derivatives
BI315_RS01290	COG0582	viral genome integration into host DNA
BI315_RS01300	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BI315_RS01320	COG1054	Belongs to the UPF0176 family
BI315_RS01330	COG1530	ribonuclease E activity
BI315_RS01340	COG3064	Membrane
BI315_RS01345	COG0428	transporter
BI315_RS01355	COG2154	pterin-4-alpha-carbinolamine dehydratase
BI315_RS01360	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BI315_RS01360	COG0316	Belongs to the HesB IscA family
BI315_RS01405	COG2226	methyltransferase
BI315_RS01405	COG1073	alpha beta
BI315_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS01490	COG1238	metal cluster binding
BI315_RS01525	COG3279	Response regulator of the LytR AlgR family
BI315_RS01575	COG4566	intracellular signal transduction
BI315_RS01585	COG5001	Diguanylate cyclase
BI315_RS01605	COG3685	Protein conserved in bacteria
BI315_RS01630	COG1648	precorrin-2 dehydrogenase activity
BI315_RS01630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI315_RS01645	COG2814	Major facilitator Superfamily
BI315_RS01660	COG1335	isochorismatase
BI315_RS01675	COG2197	response regulator
BI315_RS01690	COG0583	DNA-binding transcription factor activity
BI315_RS01695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI315_RS01700	COG3002	Belongs to the UPF0753 family
BI315_RS01715	COG1396	sequence-specific DNA binding
BI315_RS01720	COG5489	Protein of unknown function (DUF736)
BI315_RS01725	COG2003	Belongs to the UPF0758 family
BI315_RS01750	COG0582	viral genome integration into host DNA
BI315_RS01765	COG4774	siderophore transport
BI315_RS01785	COG2336	PFAM SpoVT AbrB
BI315_RS01810	COG4206	TonB-dependent receptor
BI315_RS01850	COG2274	protein secretion by the type I secretion system
BI315_RS01905	COG0270	DNA (cytosine-5-)-methyltransferase activity
BI315_RS01955	COG4804	nuclease activity
BI315_RS01970	COG5006	permease, DMT superfamily
BI315_RS01985	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI315_RS01995	COG3938	Belongs to the proline racemase family
BI315_RS02010	COG2807	transmembrane transport
BI315_RS02015	COG2207	Transcriptional regulator
BI315_RS02165	COG0210	DNA helicase
BI315_RS02245	COG2084	Dehydrogenase
BI315_RS02265	COG2003	Belongs to the UPF0758 family
BI315_RS02300	COG0582	viral genome integration into host DNA
BI315_RS02305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI315_RS02305	COG0519	Catalyzes the synthesis of GMP from XMP
BI315_RS02315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BI315_RS02325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI315_RS02325	COG0475	glutathione-regulated potassium exporter activity
BI315_RS02330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BI315_RS02340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI315_RS02345	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BI315_RS02355	COG0776	regulation of translation
BI315_RS02360	COG0539	negative regulation of cytoplasmic translation
BI315_RS02365	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BI315_RS02385	COG2957	Belongs to the agmatine deiminase family
BI315_RS02390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI315_RS02415	COG0395	ABC-type sugar transport system, permease component
BI315_RS02420	COG1175	transmembrane transport
BI315_RS02450	COG2350	Protein conserved in bacteria
BI315_RS02455	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BI315_RS02460	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BI315_RS02465	COG1187	pseudouridine synthase activity
BI315_RS02485	COG0436	Aminotransferase
BI315_RS02490	COG4133	protoheme IX ABC transporter activity
BI315_RS02510	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BI315_RS02515	COG1138	Cytochrome C-type biogenesis protein
BI315_RS02535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI315_RS02540	COG1278	Cold shock
BI315_RS02545	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BI315_RS02550	COG4988	ABC transporter
BI315_RS02560	COG1294	oxidase, subunit
BI315_RS02590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BI315_RS02605	COG0165	Argininosuccinate lyase
BI315_RS02610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BI315_RS02620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BI315_RS02625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI315_RS02635	COG0137	argininosuccinate synthase activity
BI315_RS02640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BI315_RS02650	COG0215	cysteine-tRNA ligase activity
BI315_RS02655	COG2166	iron-sulfur cluster assembly
BI315_RS02670	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BI315_RS02675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BI315_RS02705	COG4302	ethanolamine ammonia-lyase activity
BI315_RS02740	COG2963	transposase activity
BI315_RS02770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BI315_RS02775	COG0402	S-adenosylhomocysteine deaminase activity
BI315_RS02785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI315_RS02790	COG1509	lysine 2,3-aminomutase activity
BI315_RS02795	COG5001	Diguanylate cyclase
BI315_RS02795	COG3300	MHYT domain
BI315_RS02810	COG0483	inositol monophosphate 1-phosphatase activity
BI315_RS02835	COG0488	(ABC) transporter
BI315_RS02840	COG0513	Belongs to the DEAD box helicase family
BI315_RS02845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI315_RS02850	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BI315_RS02860	COG0625	glutathione transferase activity
BI315_RS02870	COG4681	YaeQ
BI315_RS02875	COG2081	HI0933 family
BI315_RS02885	COG0501	Belongs to the peptidase M48B family
BI315_RS02890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI315_RS02895	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS02920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BI315_RS02925	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI315_RS02930	COG0802	atpase or kinase
BI315_RS02935	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BI315_RS02935	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI315_RS02940	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI315_RS02945	COG1570	exodeoxyribonuclease VII activity
BI315_RS02955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI315_RS03140	COG0835	chemotaxis
BI315_RS03145	COG0840	transmembrane signaling receptor activity
BI315_RS03150	COG2094	Belongs to the DNA glycosylase MPG family
BI315_RS03155	COG1201	RNA secondary structure unwinding
BI315_RS03175	COG2969	positive regulation of protein catabolic process
BI315_RS03180	COG0625	glutathione transferase activity
BI315_RS03185	COG2857	Cytochrome c1
BI315_RS03190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BI315_RS03195	COG0723	plastoquinol--plastocyanin reductase activity
BI315_RS03205	COG0741	lytic transglycosylase activity
BI315_RS03220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI315_RS03225	COG1702	phosphate starvation-inducible protein PhoH
BI315_RS03235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BI315_RS03245	COG4535	Mg2 and Co2 transporter CorC
BI315_RS03260	COG1012	belongs to the aldehyde dehydrogenase family
BI315_RS03265	COG1177	transmembrane transport
BI315_RS03270	COG1176	ABC-type spermidine putrescine transport system, permease component I
BI315_RS03275	COG3842	ATPase activity
BI315_RS03295	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BI315_RS03310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BI315_RS03315	COG0174	glutamine synthetase
BI315_RS03320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI315_RS03330	COG2703	oxygen carrier activity
BI315_RS03335	COG0477	Major facilitator Superfamily
BI315_RS03345	COG0243	molybdopterin cofactor binding
BI315_RS03350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BI315_RS03355	COG2223	nitrite transmembrane transporter activity
BI315_RS03370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BI315_RS03380	COG2733	membrane
BI315_RS03385	COG0784	Response regulator, receiver
BI315_RS03385	COG2205	protein histidine kinase activity
BI315_RS03385	COG5002	protein histidine kinase activity
BI315_RS03395	COG0477	Major facilitator Superfamily
BI315_RS03405	COG2902	Dehydrogenase
BI315_RS03415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_RS03420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI315_RS03425	COG1609	Transcriptional regulator
BI315_RS03430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI315_RS03430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI315_RS03435	COG1105	Belongs to the carbohydrate kinase PfkB family
BI315_RS03440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI315_RS03440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI315_RS03485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI315_RS03495	COG1862	Preprotein translocase
BI315_RS03500	COG0343	queuine tRNA-ribosyltransferase activity
BI315_RS03505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BI315_RS03540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BI315_RS03545	COG3291	Pkd domain containing protein
BI315_RS03550	COG0405	Gamma-glutamyltransferase
BI315_RS03555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BI315_RS03570	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BI315_RS03575	COG0742	ribosomal rna small subunit methyltransferase
BI315_RS03580	COG0326	Molecular chaperone. Has ATPase activity
BI315_RS03660	COG0531	amino acid
BI315_RS03675	COG0006	proline dipeptidase activity
BI315_RS03685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI315_RS03700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI315_RS03705	COG3938	Belongs to the proline racemase family
BI315_RS03715	COG0552	protein localization to endoplasmic reticulum
BI315_RS03725	COG1194	a g-specific adenine glycosylase
BI315_RS03730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BI315_RS03735	COG0784	Response regulator, receiver
BI315_RS03735	COG4191	Histidine kinase
BI315_RS03750	COG0322	excinuclease ABC activity
BI315_RS03765	COG3040	lipid binding
BI315_RS03780	COG1960	acyl-CoA dehydrogenase activity
BI315_RS03790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BI315_RS03810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI315_RS03815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI315_RS03820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI315_RS03845	COG0438	transferase activity, transferring glycosyl groups
BI315_RS03855	COG0438	transferase activity, transferring glycosyl groups
BI315_RS03860	COG0438	transferase activity, transferring glycosyl groups
BI315_RS03910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI315_RS03910	COG0072	phenylalanine-tRNA ligase activity
BI315_RS03915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BI315_RS03930	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BI315_RS03935	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BI315_RS03960	COG1082	Xylose isomerase domain protein TIM barrel
BI315_RS03990	COG0366	Alpha amylase catalytic
BI315_RS03995	COG2963	transposase activity
BI315_RS04000	COG2801	Transposase and inactivated derivatives
BI315_RS04055	COG3702	type iv secretory pathway
BI315_RS04075	COG2948	multi-organism process
BI315_RS04095	COG3505	Type IV secretory pathway VirD4
BI315_RS04110	COG0556	nucleotide-excision repair
BI315_RS04205	COG4695	Portal protein
BI315_RS04250	COG3179	chitinase
BI315_RS04350	COG3275	phosphorelay sensor kinase activity
BI315_RS04355	COG1611	Belongs to the LOG family
BI315_RS04370	COG2095	MarC family integral membrane protein
BI315_RS04380	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI315_RS04415	COG1185	polyribonucleotide nucleotidyltransferase activity
BI315_RS04420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BI315_RS04425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BI315_RS04430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BI315_RS04435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BI315_RS04440	COG0195	Participates in both transcription termination and antitermination
BI315_RS04445	COG0779	Required for maturation of 30S ribosomal subunits
BI315_RS04455	COG1007	ATP synthesis coupled electron transport
BI315_RS04480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI315_RS04485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BI315_RS04495	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BI315_RS04500	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BI315_RS04505	COG0649	NAD binding
BI315_RS04510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI315_RS04515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI315_RS04520	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI315_RS04535	COG0149	triose-phosphate isomerase activity
BI315_RS04540	COG0300	oxidoreductase activity
BI315_RS04570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI315_RS04575	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BI315_RS04580	COG0159	tryptophan synthase activity
BI315_RS04590	COG0133	tryptophan synthase activity
BI315_RS04600	COG0135	phosphoribosylanthranilate isomerase activity
BI315_RS04605	COG0101	tRNA pseudouridine synthase activity
BI315_RS04630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BI315_RS04635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI315_RS04640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BI315_RS04645	COG2890	protein-(glutamine-N5) methyltransferase activity
BI315_RS04655	COG0688	phosphatidylethanolamine metabolic process
BI315_RS04670	COG0433	COG0433 Predicted ATPase
BI315_RS04675	COG0494	nUDIX hydrolase
BI315_RS04695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI315_RS04700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI315_RS04725	COG0717	Belongs to the dCTP deaminase family
BI315_RS04735	COG0489	protein tyrosine kinase activity
BI315_RS04755	COG3590	peptidase
BI315_RS04765	COG3590	peptidase
BI315_RS04785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI315_RS04790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI315_RS04795	COG2311	Membrane
BI315_RS04800	COG1047	Peptidyl-prolyl cis-trans
BI315_RS04805	COG0791	NLP P60 protein
BI315_RS04810	COG0791	NLP P60 protein
BI315_RS04820	COG4106	trans-aconitate 2-methyltransferase activity
BI315_RS04825	COG1301	dicarboxylic acid transport
BI315_RS04830	COG1785	Belongs to the alkaline phosphatase family
BI315_RS04840	COG0037	tRNA processing
BI315_RS04845	COG1722	exodeoxyribonuclease VII activity
BI315_RS04850	COG0142	geranyltranstransferase activity
BI315_RS04855	COG4104	PAAR repeat-containing protein
BI315_RS04865	COG0312	modulator of DNA gyrase
BI315_RS04870	COG3028	Belongs to the UPF0307 family
BI315_RS04875	COG0312	modulator of DNA gyrase
BI315_RS04885	COG3164	Protein of unknown function
BI315_RS04895	COG0424	maF-like protein
BI315_RS04900	COG2968	Membrane
BI315_RS04915	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BI315_RS04930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BI315_RS04945	COG0495	leucyl-tRNA aminoacylation
BI315_RS04955	COG3118	belongs to the thioredoxin family
BI315_RS04985	COG2155	Conserved Protein
BI315_RS05030	COG1132	(ABC) transporter
BI315_RS05060	COG1538	Outer membrane efflux protein
BI315_RS05065	COG0745	RESPONSE REGULATOR receiver
BI315_RS05070	COG5000	phosphorelay sensor kinase activity
BI315_RS05070	COG5002	protein histidine kinase activity
BI315_RS05075	COG0475	glutathione-regulated potassium exporter activity
BI315_RS05085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI315_RS05110	COG1187	pseudouridine synthase activity
BI315_RS05115	COG5001	Diguanylate cyclase
BI315_RS05115	COG5002	protein histidine kinase activity
BI315_RS05235	COG0667	Aldo Keto reductase
BI315_RS05245	COG2814	Major facilitator Superfamily
BI315_RS05250	COG0583	DNA-binding transcription factor activity
BI315_RS05260	COG2207	Transcriptional regulator
BI315_RS05270	COG1309	transcriptional regulator
BI315_RS05295	COG0735	belongs to the Fur family
BI315_RS05300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI315_RS05325	COG4452	Inner membrane protein CreD
BI315_RS05335	COG2205	protein histidine kinase activity
BI315_RS05340	COG0745	RESPONSE REGULATOR receiver
BI315_RS05345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BI315_RS05355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BI315_RS05390	COG2198	Histidine kinase
BI315_RS05390	COG0643	Histidine kinase
BI315_RS05400	COG0840	transmembrane signaling receptor activity
BI315_RS05405	COG0835	chemotaxis
BI315_RS05410	COG2199	diguanylate cyclase activity
BI315_RS05410	COG2202	Pas domain
BI315_RS05410	COG2200	EAL domain
BI315_RS05415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI315_RS05420	COG2201	protein-glutamate methylesterase activity
BI315_RS05425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI315_RS05430	COG3590	peptidase
BI315_RS05440	COG0588	phosphoglycerate mutase activity
BI315_RS05445	COG1515	deoxyribonuclease V activity
BI315_RS05455	COG1741	Belongs to the pirin family
BI315_RS05470	COG1741	Belongs to the pirin family
BI315_RS05475	COG1966	Carbon starvation protein
BI315_RS05480	COG2879	small protein
BI315_RS05525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI315_RS05530	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI315_RS05535	COG2080	2 iron, 2 sulfur cluster binding
BI315_RS05545	COG5001	Diguanylate cyclase
BI315_RS05545	COG4251	negative regulation of phosphorylation
BI315_RS05545	COG3706	GGDEF domain
BI315_RS05545	COG2203	Gaf domain
BI315_RS05550	COG0629	single-stranded DNA binding
BI315_RS05555	COG0142	geranyltranstransferase activity
BI315_RS05570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BI315_RS05585	COG0527	aspartate kinase activity
BI315_RS05590	COG0384	phenazine biosynthesis protein PhzF
BI315_RS05595	COG0384	phenazine biosynthesis protein PhzF
BI315_RS05605	COG1764	response to oxidative stress
BI315_RS05610	COG0540	Belongs to the ATCase OTCase family
BI315_RS05615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BI315_RS05620	COG1678	Uncharacterized ACR, COG1678
BI315_RS05630	COG0519	Catalyzes the synthesis of GMP from XMP
BI315_RS05640	COG5297	Belongs to the glycosyl hydrolase family 6
BI315_RS05655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BI315_RS05670	COG0739	heme binding
BI315_RS05690	COG0693	protein deglycase activity
BI315_RS05700	COG1959	2 iron, 2 sulfur cluster binding
BI315_RS05705	COG0719	Fe-S assembly protein
BI315_RS05710	COG0396	ATPase activity
BI315_RS05715	COG0719	Fe-S assembly protein
BI315_RS05720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BI315_RS05730	COG2146	nitrite reductase [NAD(P)H] activity
BI315_RS05735	COG4774	siderophore transport
BI315_RS05740	COG3128	pkhd-type hydroxylase
BI315_RS05765	COG1477	protein flavinylation
BI315_RS05770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI315_RS05785	COG1555	photosystem II stabilization
BI315_RS05790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI315_RS05800	COG3178	'Phosphotransferase
BI315_RS05805	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BI315_RS05815	COG0628	permease
BI315_RS05825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BI315_RS05835	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BI315_RS05855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BI315_RS05860	COG0271	Belongs to the BolA IbaG family
BI315_RS05870	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BI315_RS05880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BI315_RS05885	COG1137	ATPase activity
BI315_RS05900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI315_RS05905	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BI315_RS05910	COG1660	Displays ATPase and GTPase activities
BI315_RS05920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI315_RS05925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI315_RS05930	COG2239	Acts as a magnesium transporter
BI315_RS05945	COG1294	oxidase, subunit
BI315_RS05950	COG1271	oxidase subunit
BI315_RS05960	COG1113	amino acid transport
BI315_RS05990	COG2197	response regulator
BI315_RS05995	COG0531	amino acid
BI315_RS06030	COG1234	tRNA 3'-trailer cleavage
BI315_RS06075	COG2814	Major facilitator Superfamily
BI315_RS06085	COG0754	glutathionylspermidine amidase activity
BI315_RS06110	COG1842	Phage shock protein A
BI315_RS06120	COG0259	pyridoxamine-phosphate oxidase activity
BI315_RS06125	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BI315_RS06130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BI315_RS06140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BI315_RS06215	COG2814	Major facilitator Superfamily
BI315_RS06230	COG0745	RESPONSE REGULATOR receiver
BI315_RS06235	COG2205	protein histidine kinase activity
BI315_RS06235	COG2198	Histidine kinase
BI315_RS06235	COG0784	Response regulator, receiver
BI315_RS06240	COG2205	protein histidine kinase activity
BI315_RS06240	COG2198	Histidine kinase
BI315_RS06240	COG0784	Response regulator, receiver
BI315_RS06245	COG2353	YceI-like domain
BI315_RS06265	COG1760	l-serine dehydratase
BI315_RS06280	COG0460	homoserine dehydrogenase
BI315_RS06280	COG0527	aspartate kinase activity
BI315_RS06285	COG0626	cystathionine gamma-synthase activity
BI315_RS06290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI315_RS06295	COG0739	heme binding
BI315_RS06300	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BI315_RS06305	COG1272	protein, Hemolysin III
BI315_RS06310	COG2982	Protein involved in outer membrane biogenesis
BI315_RS06315	COG0517	IMP dehydrogenase activity
BI315_RS06315	COG0516	GMP reductase activity
BI315_RS06320	COG0463	Glycosyl transferase, family 2
BI315_RS06325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI315_RS06330	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BI315_RS06340	COG4771	TonB-dependent receptor
BI315_RS06350	COG1309	transcriptional regulator
BI315_RS06360	COG1960	acyl-CoA dehydrogenase activity
BI315_RS06385	COG0509	glycine decarboxylation via glycine cleavage system
BI315_RS06390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BI315_RS06400	COG0330	HflC and HflK could
BI315_RS06405	COG1742	UPF0060 membrane protein
BI315_RS06410	COG3956	TIGRFAM MazG family protein
BI315_RS06420	COG0494	nUDIX hydrolase
BI315_RS06430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BI315_RS06435	COG0837	glucose binding
BI315_RS06450	COG1388	LysM domain
BI315_RS06450	COG3858	chitin binding
BI315_RS06465	COG1472	Belongs to the glycosyl hydrolase 3 family
BI315_RS06480	COG0531	amino acid
BI315_RS06490	COG1486	melibiose metabolic process
BI315_RS06500	COG3537	Alpha-1,2-mannosidase
BI315_RS06540	COG3142	Participates in the control of copper homeostasis
BI315_RS06545	COG1446	asparaginase
BI315_RS06580	COG0643	Histidine kinase
BI315_RS06580	COG0784	Response regulator, receiver
BI315_RS06580	COG2198	Histidine kinase
BI315_RS06585	COG0840	transmembrane signaling receptor activity
BI315_RS06590	COG0835	chemotaxis
BI315_RS06605	COG0189	ligase activity
BI315_RS06615	COG1397	ADP-ribosylglycohydrolase
BI315_RS06625	COG1199	ATP-dependent helicase activity
BI315_RS06635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI315_RS06640	COG1215	transferase activity, transferring glycosyl groups
BI315_RS06660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI315_RS06670	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BI315_RS06675	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BI315_RS06680	COG0535	radical SAM domain protein
BI315_RS06685	COG0535	radical SAM domain protein
BI315_RS06700	COG0837	glucose binding
BI315_RS06715	COG1643	Atp-dependent helicase
BI315_RS06720	COG0783	Belongs to the Dps family
BI315_RS06730	COG0514	ATP-dependent DNA helicase (RecQ)
BI315_RS06765	COG0840	transmembrane signaling receptor activity
BI315_RS06785	COG3920	Histidine kinase
BI315_RS06790	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BI315_RS06800	COG0602	queuosine metabolic process
BI315_RS06810	COG2885	chlorophyll binding
BI315_RS06815	COG0823	Involved in the tonB-independent uptake of proteins
BI315_RS06825	COG0848	biopolymer transport protein
BI315_RS06835	COG0824	Thioesterase
BI315_RS06840	COG2255	four-way junction helicase activity
BI315_RS06850	COG3158	transport of potassium into the cell
BI315_RS06855	COG0632	four-way junction helicase activity
BI315_RS06860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BI315_RS06865	COG0217	transcriptional regulatory protein
BI315_RS06880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BI315_RS06895	COG0477	Major facilitator Superfamily
BI315_RS06940	COG0488	(ABC) transporter
BI315_RS06980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI315_RS06980	COG4651	solute:proton antiporter activity
BI315_RS07005	COG4772	TonB-dependent receptor
BI315_RS07015	COG4264	IucA IucC family
BI315_RS07030	COG0019	diaminopimelate decarboxylase activity
BI315_RS07055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BI315_RS07065	COG1492	cobalamin metabolic process
BI315_RS07075	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI315_RS07095	COG4206	TonB-dependent receptor
BI315_RS07100	COG0542	response to heat
BI315_RS07105	COG1116	anion transmembrane transporter activity
BI315_RS07110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI315_RS07115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI315_RS07120	COG0667	Aldo Keto reductase
BI315_RS07125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI315_RS07130	COG4771	TonB-dependent receptor
BI315_RS07135	COG2827	Endonuclease containing a URI domain
BI315_RS07175	COG1877	trehalose-phosphatase activity
BI315_RS07180	COG3387	PFAM Glycoside hydrolase 15-related
BI315_RS07200	COG0840	transmembrane signaling receptor activity
BI315_RS07205	COG3011	Protein conserved in bacteria
BI315_RS07220	COG0564	pseudouridine synthase activity
BI315_RS07225	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI315_RS07235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI315_RS07235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BI315_RS07265	COG2951	lytic endotransglycosylase activity
BI315_RS07270	COG4644	lycopene metabolic process
BI315_RS07295	COG2369	cell adhesion
BI315_RS07320	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BI315_RS07325	COG0045	succinate-CoA ligase (ADP-forming) activity
BI315_RS07340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI315_RS07375	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BI315_RS07380	COG0237	dephospho-CoA kinase activity
BI315_RS07410	COG5002	protein histidine kinase activity
BI315_RS07415	COG0745	RESPONSE REGULATOR receiver
BI315_RS07500	COG2003	Belongs to the UPF0758 family
BI315_RS07525	COG0784	Response regulator, receiver
BI315_RS07525	COG4191	Histidine kinase
BI315_RS07530	COG0784	Response regulator, receiver
BI315_RS07530	COG4191	Histidine kinase
BI315_RS07655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BI315_RS07685	COG2022	thiamine diphosphate biosynthetic process
BI315_RS07695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BI315_RS07700	COG3273	potassium ion transport
BI315_RS07700	COG0471	metal ion transport
BI315_RS07725	COG1970	mechanosensitive ion channel activity
BI315_RS07735	COG1609	Transcriptional regulator
BI315_RS07745	COG3250	beta-galactosidase activity
BI315_RS07750	COG4948	Mandelate Racemase Muconate Lactonizing
BI315_RS07765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI315_RS07775	COG0308	aminopeptidase N
BI315_RS07815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI315_RS07825	COG0529	Catalyzes the synthesis of activated sulfate
BI315_RS07825	COG2895	sulfate adenylyltransferase (ATP) activity
BI315_RS07830	COG0175	sulfate reduction
BI315_RS07835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI315_RS07840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI315_RS07845	COG0175	sulfate reduction
BI315_RS07865	COG0784	Response regulator, receiver
BI315_RS07865	COG2198	Histidine kinase
BI315_RS07865	COG2205	protein histidine kinase activity
BI315_RS07885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI315_RS07885	COG1648	precorrin-2 dehydrogenase activity
BI315_RS07900	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BI315_RS07905	COG3588	fructose-bisphosphate aldolase
BI315_RS07920	COG0469	pyruvate kinase activity
BI315_RS07930	COG0126	phosphoglycerate kinase activity
BI315_RS07955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BI315_RS07965	COG3047	cAMP biosynthetic process
BI315_RS07970	COG3047	cAMP biosynthetic process
BI315_RS07980	COG3453	Protein conserved in bacteria
BI315_RS07980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI315_RS07985	COG0725	ABC transporter, periplasmic molybdate-binding protein
BI315_RS07990	COG4149	molybdate abc transporter
BI315_RS07995	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BI315_RS08030	COG1376	ErfK ybiS ycfS ynhG family protein
BI315_RS08035	COG0739	heme binding
BI315_RS08045	COG4773	Receptor
BI315_RS08050	COG0596	Alpha beta hydrolase
BI315_RS08055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BI315_RS08060	COG1301	dicarboxylic acid transport
BI315_RS08075	COG2304	oxidoreductase activity
BI315_RS08095	COG0714	Associated with various cellular activities
BI315_RS08130	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BI315_RS08155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI315_RS08165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI315_RS08175	COG0194	GDP metabolic process
BI315_RS08180	COG1561	YicC-like family, N-terminal region
BI315_RS08185	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BI315_RS08195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BI315_RS08200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BI315_RS08215	COG0006	proline dipeptidase activity
BI315_RS08225	COG0006	proline dipeptidase activity
BI315_RS08230	COG3079	Belongs to the UPF0149 family
BI315_RS08250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BI315_RS08260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BI315_RS08270	COG2912	Transglutaminase-like superfamily
BI315_RS08275	COG1773	rubredoxin
BI315_RS08280	COG0352	thiamine-phosphate diphosphorylase activity
BI315_RS08295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BI315_RS08310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI315_RS08340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BI315_RS08345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI315_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS08365	COG0671	phosphoesterase, PA-phosphatase related
BI315_RS08370	COG3781	membrane
BI315_RS08380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI315_RS08385	COG0563	adenylate kinase activity
BI315_RS08400	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BI315_RS08410	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BI315_RS08430	COG3710	Transcriptional regulator
BI315_RS08435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BI315_RS08450	COG0840	transmembrane signaling receptor activity
BI315_RS08455	COG0405	Gamma-glutamyltransferase
BI315_RS08460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BI315_RS08480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI315_RS08485	COG0473	3-isopropylmalate dehydrogenase activity
BI315_RS08490	COG0066	3-isopropylmalate dehydratase activity
BI315_RS08495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BI315_RS08515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI315_RS08520	COG1538	Outer membrane efflux protein
BI315_RS08525	COG1519	Transferase
BI315_RS08535	COG1560	Kdo2-lipid A biosynthetic process
BI315_RS08560	COG0281	malic enzyme
BI315_RS08560	COG0280	phosphate acetyltransferase
BI315_RS08565	COG1301	dicarboxylic acid transport
BI315_RS08590	COG0583	DNA-binding transcription factor activity
BI315_RS08600	COG0667	Aldo Keto reductase
BI315_RS08615	COG2197	response regulator
BI315_RS08630	COG0642	Histidine kinase
BI315_RS08650	COG2851	Citrate transporter
BI315_RS08655	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS08660	COG1609	Transcriptional regulator
BI315_RS08665	COG2211	Major facilitator Superfamily
BI315_RS08690	COG1162	GTPase activity
BI315_RS08720	COG4773	Receptor
BI315_RS08725	COG0726	polysaccharide deacetylase
BI315_RS08730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI315_RS08745	COG2963	transposase activity
BI315_RS08750	COG2801	Transposase and inactivated derivatives
BI315_RS08775	COG1307	EDD domain protein, DegV family
BI315_RS08780	COG0242	peptide deformylase activity
BI315_RS08810	COG0457	Tetratricopeptide repeat
BI315_RS08815	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BI315_RS08820	COG1215	transferase activity, transferring glycosyl groups
BI315_RS08825	COG1215	transferase activity, transferring glycosyl groups
BI315_RS08840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BI315_RS08895	COG2188	Transcriptional regulator
BI315_RS08905	COG1450	Type ii and iii secretion system protein
BI315_RS08920	COG3166	PFAM Fimbrial assembly family protein
BI315_RS08925	COG3156	type II secretion system protein K
BI315_RS08930	COG4795	General secretion pathway protein
BI315_RS08935	COG2165	general secretion pathway protein
BI315_RS08940	COG4970	Tfp pilus assembly protein FimT
BI315_RS08945	COG2165	general secretion pathway protein
BI315_RS08950	COG1459	type II secretion system
BI315_RS08960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI315_RS08965	COG1404	Belongs to the peptidase S8 family
BI315_RS08970	COG5295	Hep Hag repeat protein
BI315_RS08975	COG1404	Belongs to the peptidase S8 family
BI315_RS08980	COG5295	Hep Hag repeat protein
BI315_RS08990	COG0047	phosphoribosylformylglycinamidine synthase activity
BI315_RS08990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BI315_RS09005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI315_RS09015	COG4974	Belongs to the 'phage' integrase family
BI315_RS09030	COG0795	lipopolysaccharide-transporting ATPase activity
BI315_RS09040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI315_RS09055	COG0525	valine-tRNA ligase activity
BI315_RS09085	COG1183	phosphatidylcholine synthase activity
BI315_RS09095	COG0442	prolyl-tRNA aminoacylation
BI315_RS09110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI315_RS09115	COG1127	ABC transporter
BI315_RS09120	COG3218	ABC-type transport auxiliary lipoprotein component
BI315_RS09120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI315_RS09155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI315_RS09160	COG0662	Cupin 2, conserved barrel domain protein
BI315_RS09160	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BI315_RS09195	COG2086	electron transfer activity
BI315_RS09210	COG0546	phosphoglycolate phosphatase activity
BI315_RS09210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BI315_RS09215	COG0277	FAD linked oxidase domain protein
BI315_RS09230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI315_RS09260	COG0438	transferase activity, transferring glycosyl groups
BI315_RS09260	COG1216	Glycosyl transferase, family 2
BI315_RS09280	COG0626	cystathionine gamma-synthase activity
BI315_RS09315	COG0625	glutathione transferase activity
BI315_RS09330	COG0513	Belongs to the DEAD box helicase family
BI315_RS09340	COG4206	TonB-dependent receptor
BI315_RS09350	COG0720	synthase
BI315_RS09360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BI315_RS09365	COG1956	GAF domain-containing protein
BI315_RS09375	COG2819	hydrolase of the alpha beta superfamily
BI315_RS09390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI315_RS09395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI315_RS09410	COG0339	signal peptide processing
BI315_RS09465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI315_RS09470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_RS09475	COG1136	(ABC) transporter
BI315_RS09475	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI315_RS09480	COG0577	efflux transmembrane transporter activity
BI315_RS09480	COG1136	(ABC) transporter
BI315_RS09485	COG0577	efflux transmembrane transporter activity
BI315_RS09500	COG4191	Histidine kinase
BI315_RS09505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BI315_RS09520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BI315_RS09525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BI315_RS09530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BI315_RS09535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BI315_RS09540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BI315_RS09545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BI315_RS09555	COG0356	it plays a direct role in the translocation of protons across the membrane
BI315_RS09575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI315_RS09585	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI315_RS09625	COG2011	ABC-type metal ion transport system permease component
BI315_RS09630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI315_RS09635	COG0697	spore germination
BI315_RS09640	COG1666	GTP binding
BI315_RS09650	COG2198	Histidine kinase
BI315_RS09650	COG5002	protein histidine kinase activity
BI315_RS09650	COG0784	Response regulator, receiver
BI315_RS09670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI315_RS09675	COG1187	pseudouridine synthase activity
BI315_RS09680	COG2813	Specifically methylates the guanine in position
BI315_RS09700	COG2205	protein histidine kinase activity
BI315_RS09700	COG2202	Pas domain
BI315_RS09720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BI315_RS09725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI315_RS09790	COG0842	Transport permease protein
BI315_RS09795	COG1131	(ABC) transporter
BI315_RS09800	COG0025	NhaP-type Na H and K H
BI315_RS09810	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BI315_RS09815	COG1573	uracil-dna glycosylase
BI315_RS09825	COG3384	dioxygenase
BI315_RS09835	COG0583	DNA-binding transcription factor activity
BI315_RS09845	COG0667	Aldo Keto reductase
BI315_RS09880	COG0531	amino acid
BI315_RS09895	COG2972	Histidine kinase
BI315_RS09920	COG3685	Protein conserved in bacteria
BI315_RS09925	COG3546	catalase activity
BI315_RS09975	COG1271	oxidase subunit
BI315_RS09980	COG1294	oxidase, subunit
BI315_RS09995	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS10000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BI315_RS10020	COG1132	(ABC) transporter
BI315_RS10035	COG1063	alcohol dehydrogenase
BI315_RS10110	COG0251	oxidation-reduction process
BI315_RS10145	COG0840	transmembrane signaling receptor activity
BI315_RS10165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI315_RS10210	COG0024	Methionine aminopeptidase
BI315_RS10245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI315_RS10250	COG1490	D-aminoacyl-tRNA deacylase activity
BI315_RS10255	COG1560	Kdo2-lipid A biosynthetic process
BI315_RS10310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BI315_RS10310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI315_RS10315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BI315_RS10320	COG0242	peptide deformylase activity
BI315_RS10325	COG1652	LysM domain
BI315_RS10330	COG0758	DNA mediated transformation
BI315_RS10335	COG2922	Belongs to the Smg family
BI315_RS10350	COG1754	DNA topoisomerase type I activity
BI315_RS10350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI315_RS10355	COG0009	L-threonylcarbamoyladenylate synthase
BI315_RS10370	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS10380	COG0616	signal peptide processing
BI315_RS10385	COG0534	Mate efflux family protein
BI315_RS10405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BI315_RS10410	COG0625	glutathione transferase activity
BI315_RS10425	COG1252	NADH dehydrogenase
BI315_RS10430	COG2860	membrane
BI315_RS10435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI315_RS10440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BI315_RS10445	COG3437	response regulator, receiver
BI315_RS10450	COG2177	Part of the ABC transporter FtsEX involved in
BI315_RS10455	COG2884	Cell division ATP-binding protein ftsE
BI315_RS10460	COG0513	Belongs to the DEAD box helicase family
BI315_RS10465	COG3118	belongs to the thioredoxin family
BI315_RS10470	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BI315_RS10475	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BI315_RS10480	COG0583	DNA-binding transcription factor activity
BI315_RS10525	COG1518	maintenance of DNA repeat elements
BI315_RS10530	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BI315_RS10540	COG1652	LysM domain
BI315_RS10545	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI315_RS10545	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI315_RS10550	COG1473	amidohydrolase
BI315_RS10555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_RS10560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI315_RS10570	COG5383	Protein conserved in bacteria
BI315_RS10615	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BI315_RS10620	COG3023	N-Acetylmuramoyl-L-alanine amidase
BI315_RS10630	COG4948	Mandelate Racemase Muconate Lactonizing
BI315_RS10640	COG0531	amino acid
BI315_RS10655	COG4682	membrane
BI315_RS10660	COG2133	pyrroloquinoline quinone binding
BI315_RS10670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BI315_RS10675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BI315_RS10685	COG1610	YqeY-like protein
BI315_RS10695	COG1295	ribonuclease BN
BI315_RS10700	COG0358	DNA primase activity
BI315_RS10715	COG0109	protoheme IX farnesyltransferase activity
BI315_RS10745	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BI315_RS10760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BI315_RS10805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BI315_RS10810	COG0739	heme binding
BI315_RS10815	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BI315_RS10825	COG2211	Major facilitator Superfamily
BI315_RS10830	COG0708	Exodeoxyribonuclease III
BI315_RS10835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BI315_RS10845	COG1192	Involved in chromosome partitioning
BI315_RS10850	COG1475	DNA binding
BI315_RS10870	COG0463	Glycosyl transferase, family 2
BI315_RS10890	COG0756	dUTP diphosphatase activity
BI315_RS10895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BI315_RS10900	COG2003	Belongs to the UPF0758 family
BI315_RS10905	COG0018	arginyl-trna synthetase
BI315_RS10920	COG4221	oxidoreductase activity
BI315_RS10925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI315_RS10925	COG2755	lipolytic protein G-D-S-L family
BI315_RS10935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI315_RS10940	COG1166	arginine decarboxylase activity
BI315_RS10945	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BI315_RS10985	COG0606	chelatase, subunit chli
BI315_RS11000	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BI315_RS11040	COG1690	Belongs to the RtcB family
BI315_RS11075	COG1090	epimerase
BI315_RS11085	COG0642	Histidine kinase
BI315_RS11115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI315_RS11140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI315_RS11145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI315_RS11160	COG0753	catalase activity
BI315_RS11175	COG2197	response regulator
BI315_RS11180	COG4585	Histidine kinase
BI315_RS11185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_RS11190	COG1136	(ABC) transporter
BI315_RS11215	COG0697	spore germination
BI315_RS11235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI315_RS11240	COG0180	Tryptophanyl-tRNA synthetase
BI315_RS11245	COG3237	CsbD-like
BI315_RS11290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BI315_RS11305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BI315_RS11355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI315_RS11395	COG1199	ATP-dependent helicase activity
BI315_RS11410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BI315_RS11475	COG0625	glutathione transferase activity
BI315_RS11515	COG4555	ABC transporter
BI315_RS11525	COG1476	TRANSCRIPTIONal
BI315_RS11570	COG0633	Ferredoxin
BI315_RS11570	COG0543	2 iron, 2 sulfur cluster binding
BI315_RS11575	COG1131	(ABC) transporter
BI315_RS11580	COG0842	Transport permease protein
BI315_RS11590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BI315_RS11625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI315_RS11635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI315_RS11650	COG1042	CoA-binding domain protein
BI315_RS11650	COG0045	succinate-CoA ligase (ADP-forming) activity
BI315_RS11650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI315_RS11655	COG2239	Acts as a magnesium transporter
BI315_RS11675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI315_RS11680	COG3387	PFAM Glycoside hydrolase 15-related
BI315_RS11695	COG3100	YcgL domain-containing protein
BI315_RS11700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BI315_RS11710	COG0463	Glycosyl transferase, family 2
BI315_RS11730	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS11770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI315_RS11785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI315_RS11815	COG1506	peptidase
BI315_RS11815	COG0823	Involved in the tonB-independent uptake of proteins
BI315_RS11815	COG4946	Tricorn protease homolog
BI315_RS11835	COG0408	coproporphyrinogen oxidase activity
BI315_RS11875	COG0515	serine threonine protein kinase
BI315_RS11875	COG2815	serine threonine protein kinase
BI315_RS11880	COG0631	protein serine/threonine phosphatase activity
BI315_RS12050	COG0210	DNA helicase
BI315_RS12065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI315_RS12070	COG0583	DNA-binding transcription factor activity
BI315_RS12075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI315_RS12090	COG2159	amidohydrolase
BI315_RS12110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_RS12130	COG0357	Ribosomal RNA small subunit methyltransferase G
BI315_RS12135	COG3540	Alkaline phosphatase
BI315_RS12145	COG2091	lysine biosynthetic process via aminoadipic acid
BI315_RS12160	COG0708	Exodeoxyribonuclease III
BI315_RS12165	COG1846	Transcriptional regulator
BI315_RS12165	COG1940	carbohydrate kinase activity
BI315_RS12175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI315_RS12185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI315_RS12190	COG3162	membrane
BI315_RS12200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI315_RS12230	COG3507	Belongs to the glycosyl hydrolase 43 family
BI315_RS12250	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS12255	COG0179	Fumarylacetoacetate (FAA) hydrolase
BI315_RS12265	COG4948	Mandelate Racemase Muconate Lactonizing
BI315_RS12275	COG3254	rhamnose metabolic process
BI315_RS12280	COG0738	Major facilitator superfamily
BI315_RS12285	COG1414	Transcriptional regulator
BI315_RS12290	COG1971	Probably functions as a manganese efflux pump
BI315_RS12295	COG2205	protein histidine kinase activity
BI315_RS12310	COG3459	Glycosyltransferase 36 associated
BI315_RS12315	COG2211	Major facilitator Superfamily
BI315_RS12320	COG3265	gluconokinase activity
BI315_RS12330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI315_RS12350	COG2911	Protein conserved in bacteria
BI315_RS12355	COG0729	surface antigen
BI315_RS12390	COG0752	glycyl-tRNA synthetase alpha subunit
BI315_RS12395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI315_RS12410	COG0519	Catalyzes the synthesis of GMP from XMP
BI315_RS12410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI315_RS12420	COG0805	protein transport
BI315_RS12425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI315_RS12430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI315_RS12440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BI315_RS12465	COG2974	May be involved in recombination
BI315_RS12470	COG0037	tRNA processing
BI315_RS12480	COG2115	Belongs to the xylose isomerase family
BI315_RS12490	COG3661	Belongs to the glycosyl hydrolase 67 family
BI315_RS12500	COG4948	Mandelate Racemase Muconate Lactonizing
BI315_RS12510	COG1472	Belongs to the glycosyl hydrolase 3 family
BI315_RS12515	COG0246	Mannitol dehydrogenase
BI315_RS12590	COG3386	PFAM SMP-30 Gluconolaconase
BI315_RS12600	COG3250	beta-galactosidase activity
BI315_RS12620	COG3693	PFAM glycoside hydrolase, family 10
BI315_RS12635	COG2211	Major facilitator Superfamily
BI315_RS12700	COG2937	Belongs to the GPAT DAPAT family
BI315_RS12735	COG0284	orotidine-5'-phosphate decarboxylase activity
BI315_RS12740	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BI315_RS12750	COG3132	Protein of unknown function, DUF480
BI315_RS12765	COG0210	DNA helicase
BI315_RS12770	COG1435	thymidine kinase activity
BI315_RS12780	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BI315_RS12790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BI315_RS12825	COG3135	benzoate transporter
BI315_RS12845	COG0676	glucose-6-phosphate 1-epimerase activity
BI315_RS12855	COG3012	SEC-C Motif Domain Protein
BI315_RS12860	COG0730	response to heat
BI315_RS12880	COG0302	gtp cyclohydrolase
BI315_RS12895	COG1566	PFAM secretion protein HlyD family protein
BI315_RS12905	COG1289	transmembrane transporter activity
BI315_RS12910	COG0477	Major facilitator Superfamily
BI315_RS12920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI315_RS12940	COG4691	Plasmid stability protein
BI315_RS12945	COG1487	ribonuclease activity
BI315_RS12970	COG0564	pseudouridine synthase activity
BI315_RS13010	COG0439	Biotin carboxylase
BI315_RS13060	COG1074	ATP-dependent DNA helicase activity
BI315_RS13065	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BI315_RS13080	COG1127	ABC transporter
BI315_RS13085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI315_RS13090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI315_RS13105	COG2853	Lipoprotein
BI315_RS13115	COG0386	Belongs to the glutathione peroxidase family
BI315_RS13125	COG1322	Protein conserved in bacteria
BI315_RS13130	COG0604	alcohol dehydrogenase
BI315_RS13150	COG0625	glutathione transferase activity
BI315_RS13160	COG0531	amino acid
BI315_RS13165	COG3537	Alpha-1,2-mannosidase
BI315_RS13180	COG3706	GGDEF domain
BI315_RS13185	COG3835	regulator
BI315_RS13190	COG1929	Belongs to the glycerate kinase type-1 family
BI315_RS13195	COG2271	Major facilitator Superfamily
BI315_RS13210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BI315_RS13220	COG0861	Integral membrane protein TerC family
BI315_RS13235	COG0584	glycerophosphoryl diester phosphodiesterase
BI315_RS13250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BI315_RS13255	COG0726	polysaccharide deacetylase
BI315_RS13260	COG0706	membrane insertase activity
BI315_RS13265	COG0594	ribonuclease P activity
BI315_RS13280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BI315_RS13290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BI315_RS13295	COG0187	DNA topoisomerase II activity
BI315_RS13305	COG0501	Belongs to the peptidase M48B family
BI315_RS13335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BI315_RS13345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI315_RS13390	COG0793	Belongs to the peptidase S41A family
BI315_RS13395	COG4942	peptidase
BI315_RS13405	COG2234	aminopeptidase activity
BI315_RS13415	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI315_RS13425	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI315_RS13430	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI315_RS13440	COG1064	alcohol dehydrogenase
BI315_RS13450	COG0493	'glutamate synthase
BI315_RS13455	COG0067	glutamate synthase
BI315_RS13455	COG0070	glutamate synthase
BI315_RS13455	COG0069	glutamate synthase activity
BI315_RS13505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BI315_RS13520	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BI315_RS13525	COG0297	glycogen (starch) synthase activity
BI315_RS13525	COG0438	transferase activity, transferring glycosyl groups
BI315_RS13545	COG0367	asparagine synthase
BI315_RS13575	COG1132	(ABC) transporter
BI315_RS13605	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BI315_RS13700	COG1111	helicase
BI315_RS13700	COG1205	dead DEAH box helicase
BI315_RS13705	COG1272	protein, Hemolysin III
BI315_RS13730	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS13755	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI315_RS13770	COG2801	Transposase and inactivated derivatives
BI315_RS13825	COG3237	CsbD-like
BI315_RS13875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI315_RS13885	COG0477	Major facilitator Superfamily
BI315_RS13925	COG0714	Associated with various cellular activities
BI315_RS13955	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BI315_RS13965	COG4772	TonB-dependent receptor
BI315_RS13975	COG0662	Cupin 2, conserved barrel domain protein
BI315_RS13980	COG1012	belongs to the aldehyde dehydrogenase family
BI315_RS14005	COG1304	FMN binding
BI315_RS14020	COG4585	Histidine kinase
BI315_RS14025	COG2197	response regulator
BI315_RS14045	COG3710	Transcriptional regulator
BI315_RS14050	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BI315_RS14135	COG0366	Alpha amylase catalytic
BI315_RS14140	COG0366	Alpha amylase catalytic
BI315_RS14145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI315_RS14170	COG2755	lipolytic protein G-D-S-L family
BI315_RS14170	COG0657	acetylesterase activity
BI315_RS14180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI315_RS14195	COG3507	Belongs to the glycosyl hydrolase 43 family
BI315_RS14200	COG1609	Transcriptional regulator
BI315_RS14215	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BI315_RS14220	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS14230	COG2755	lipolytic protein G-D-S-L family
BI315_RS14245	COG3186	Phenylalanine-4-hydroxylase
BI315_RS14250	COG1522	sequence-specific DNA binding
BI315_RS14260	COG1752	Esterase of the alpha-beta hydrolase superfamily
BI315_RS14270	COG1119	ATPase activity
BI315_RS14285	COG1125	glycine betaine transport
BI315_RS14300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI315_RS14320	COG1396	sequence-specific DNA binding
BI315_RS14345	COG0489	protein tyrosine kinase activity
BI315_RS14350	COG2062	phosphohistidine phosphatase, SixA
BI315_RS14360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI315_RS14405	COG1968	undecaprenyl-diphosphatase activity
BI315_RS14415	COG0174	glutamine synthetase
BI315_RS14420	COG0347	Belongs to the P(II) protein family
BI315_RS14425	COG0004	ammonium transporteR
BI315_RS14430	COG3852	Histidine kinase
BI315_RS14435	COG2204	response regulator
BI315_RS14440	COG2032	superoxide dismutase activity
BI315_RS14445	COG2032	superoxide dismutase activity
BI315_RS14455	COG0346	lactoylglutathione lyase activity
BI315_RS14465	COG0183	Belongs to the thiolase family
BI315_RS14500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI315_RS14505	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BI315_RS14510	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BI315_RS14525	COG0028	Belongs to the TPP enzyme family
BI315_RS14530	COG2205	protein histidine kinase activity
BI315_RS14555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BI315_RS14570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI315_RS14580	COG0596	Alpha beta hydrolase
BI315_RS14585	COG0727	PFAM Uncharacterised protein family (UPF0153)
BI315_RS14590	COG0318	PFAM AMP-dependent synthetase and ligase
BI315_RS14595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI315_RS14610	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI315_RS14625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI315_RS14635	COG0564	pseudouridine synthase activity
BI315_RS14660	COG0339	signal peptide processing
BI315_RS14690	COG0475	glutathione-regulated potassium exporter activity
BI315_RS14695	COG0583	DNA-binding transcription factor activity
BI315_RS14700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BI315_RS14705	COG2224	Isocitrate lyase
BI315_RS14735	COG4770	biotin carboxylase activity
BI315_RS14740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI315_RS14745	COG1960	acyl-CoA dehydrogenase activity
BI315_RS14805	COG0523	cobalamin synthesis protein
BI315_RS14815	COG0697	spore germination
BI315_RS14825	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BI315_RS14830	COG1846	Transcriptional regulator
BI315_RS14835	COG1764	response to oxidative stress
BI315_RS14865	COG2130	NADP-dependent
BI315_RS14880	COG1187	pseudouridine synthase activity
BI315_RS14895	COG1643	Atp-dependent helicase
BI315_RS14905	COG4807	Protein conserved in bacteria
BI315_RS14910	COG2351	hydroxyisourate hydrolase activity
BI315_RS14935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BI315_RS14980	COG2252	PERMEase
BI315_RS15005	COG0084	hydrolase, TatD family'
BI315_RS15020	COG0583	DNA-binding transcription factor activity
BI315_RS15025	COG2814	Major facilitator Superfamily
BI315_RS15040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BI315_RS15045	COG1902	pentaerythritol trinitrate reductase activity
BI315_RS15065	COG0745	RESPONSE REGULATOR receiver
BI315_RS15070	COG2205	protein histidine kinase activity
BI315_RS15075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_RS15095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI315_RS15100	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI315_RS15105	COG0583	DNA-binding transcription factor activity
BI315_RS15140	COG0702	epimerase
BI315_RS15145	COG1733	regulation of RNA biosynthetic process
BI315_RS15185	COG0129	dihydroxy-acid dehydratase activity
BI315_RS15200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BI315_RS15255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BI315_RS15260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BI315_RS15285	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BI315_RS15290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BI315_RS15300	COG3485	protocatechuate 3,4-dioxygenase
BI315_RS15305	COG3485	protocatechuate 3,4-dioxygenase
BI315_RS15315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI315_RS15320	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BI315_RS15330	COG1414	Transcriptional regulator
BI315_RS15340	COG0657	acetylesterase activity
BI315_RS15350	COG0445	tRNA wobble uridine modification
BI315_RS15360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BI315_RS15390	COG2267	carboxylic ester hydrolase activity
BI315_RS15400	COG0156	8-amino-7-oxononanoate synthase activity
BI315_RS15405	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BI315_RS15410	COG1040	competence protein
BI315_RS15415	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BI315_RS15500	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI315_RS15575	COG1511	domain protein
BI315_RS15575	COG3264	Mechanosensitive ion channel
BI315_RS15580	COG1368	sulfuric ester hydrolase activity
BI315_RS15590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI315_RS15595	COG2354	Protein conserved in bacteria
BI315_RS15605	COG0297	glycogen (starch) synthase activity
BI315_RS15610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI315_RS15615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI315_RS15640	COG0702	epimerase
BI315_RS15645	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS15680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI315_RS15685	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS15695	COG0513	Belongs to the DEAD box helicase family
BI315_RS15715	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BI315_RS15725	COG3483	tryptophan 2,3-dioxygenase activity
BI315_RS15730	COG3104	oligopeptide transport
BI315_RS15755	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BI315_RS15775	COG1320	monovalent cation:proton antiporter activity
BI315_RS15780	COG2212	antiporter activity
BI315_RS15790	COG0651	ATP synthesis coupled electron transport
BI315_RS15795	COG1006	Multisubunit Na H antiporter MnhC subunit
BI315_RS15800	COG2111	Na H antiporter
BI315_RS15800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI315_RS15845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BI315_RS15850	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BI315_RS15865	COG0456	acetyltransferase
BI315_RS15870	COG1597	lipid kinase activity
BI315_RS15895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BI315_RS15900	COG0134	indole-3-glycerol-phosphate synthase activity
BI315_RS15910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI315_RS15915	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BI315_RS15925	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BI315_RS15935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BI315_RS15950	COG1051	belongs to the nudix hydrolase family
BI315_RS15990	COG0316	Belongs to the HesB IscA family
BI315_RS16020	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI315_RS16035	COG2814	Major facilitator Superfamily
BI315_RS16040	COG0583	DNA-binding transcription factor activity
BI315_RS16045	COG2814	Major facilitator Superfamily
BI315_RS16050	COG1289	transmembrane transporter activity
BI315_RS16060	COG0151	Belongs to the GarS family
BI315_RS16070	COG0138	bifunctional purine biosynthesis protein purh
BI315_RS16075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BI315_RS16080	COG2267	carboxylic ester hydrolase activity
BI315_RS16085	COG2453	phosphatase
BI315_RS16085	COG0671	phosphoesterase, PA-phosphatase related
BI315_RS16110	COG4589	Belongs to the CDS family
BI315_RS16115	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BI315_RS16135	COG2264	protein methyltransferase activity
BI315_RS16155	COG0439	Biotin carboxylase
BI315_RS16165	COG0511	ligase activity, forming carbon-carbon bonds
BI315_RS16170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BI315_RS16180	COG1324	tolerance protein
BI315_RS16210	COG0300	oxidoreductase activity
BI315_RS16215	COG2356	endonuclease I
BI315_RS16230	COG0459	protein refolding
BI315_RS16245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BI315_RS16260	COG3386	PFAM SMP-30 Gluconolaconase
BI315_RS16270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BI315_RS16275	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI315_RS16295	COG0778	Nitroreductase
BI315_RS16300	COG2353	YceI-like domain
BI315_RS16330	COG3052	prosthetic group binding
BI315_RS16355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BI315_RS16365	COG1802	Transcriptional regulator
BI315_RS16415	COG2801	Transposase and inactivated derivatives
BI315_RS16425	COG4221	oxidoreductase activity
BI315_RS16440	COG4221	oxidoreductase activity
BI315_RS16450	COG0435	Glutathione S-transferase
BI315_RS16475	COG2409	Drug exporters of the RND superfamily
BI315_RS16485	COG1506	peptidase
BI315_RS16485	COG0823	Involved in the tonB-independent uptake of proteins
BI315_RS16525	COG0697	spore germination
BI315_RS16540	COG1113	amino acid transport
BI315_RS16560	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
BI315_RS16610	COG0840	transmembrane signaling receptor activity
BI315_RS16615	COG5297	Belongs to the glycosyl hydrolase family 6
BI315_RS16615	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI315_RS16620	COG0659	secondary active sulfate transmembrane transporter activity
BI315_RS16650	COG2943	transferase activity, transferring hexosyl groups
BI315_RS16660	COG3275	phosphorelay sensor kinase activity
BI315_RS16670	COG0181	hydroxymethylbilane synthase activity
BI315_RS16700	COG1505	serine-type exopeptidase activity
BI315_RS16705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI315_RS16710	COG0436	Aminotransferase
BI315_RS16725	COG2832	Protein of unknown function (DUF454)
BI315_RS16735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BI315_RS16745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BI315_RS16750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BI315_RS16755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BI315_RS16780	COG2226	methyltransferase
BI315_RS16785	COG5001	Diguanylate cyclase
BI315_RS16785	COG3300	MHYT domain
BI315_RS16790	COG0308	aminopeptidase N
BI315_RS16840	COG3284	Transcriptional regulator
BI315_RS16845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI315_RS16850	COG1077	Cell shape determining protein MreB Mrl
BI315_RS16855	COG1792	Involved in formation and maintenance of cell shape
BI315_RS16870	COG0772	Belongs to the SEDS family
BI315_RS16880	COG2951	lytic endotransglycosylase activity
BI315_RS16885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BI315_RS16895	COG1686	Belongs to the peptidase S11 family
BI315_RS16905	COG2921	Belongs to the UPF0250 family
BI315_RS16910	COG0321	lipoyl(octanoyl) transferase activity
BI315_RS16915	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BI315_RS16930	COG0583	DNA-binding transcription factor activity
BI315_RS16940	COG1056	cytidyltransferase-related domain
BI315_RS16940	COG1051	belongs to the nudix hydrolase family
BI315_RS16975	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BI315_RS16980	COG0673	inositol 2-dehydrogenase activity
BI315_RS16985	COG2823	Periplasmic or secreted lipoprotein
BI315_RS16990	COG4251	negative regulation of phosphorylation
BI315_RS16995	COG0784	Response regulator, receiver
BI315_RS17000	COG4191	Histidine kinase
BI315_RS17005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BI315_RS17065	COG1459	type II secretion system
BI315_RS17130	COG2188	Transcriptional regulator
BI315_RS17140	COG1609	Transcriptional regulator
BI315_RS17145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI315_RS17150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BI315_RS17160	COG0617	tRNA 3'-terminal CCA addition
BI315_RS17165	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BI315_RS17170	COG1012	belongs to the aldehyde dehydrogenase family
BI315_RS17175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI315_RS17190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI315_RS17205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BI315_RS17210	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BI315_RS17230	COG2205	protein histidine kinase activity
BI315_RS17260	COG3791	Glutathione-dependent formaldehyde-activating
BI315_RS17275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI315_RS17285	COG0697	spore germination
BI315_RS17295	COG0488	(ABC) transporter
BI315_RS17305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BI315_RS17310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BI315_RS17320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI315_RS17320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI315_RS17340	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BI315_RS17345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI315_RS17350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BI315_RS17375	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BI315_RS17380	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BI315_RS17385	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BI315_RS17390	COG2205	protein histidine kinase activity
BI315_RS17395	COG0745	RESPONSE REGULATOR receiver
BI315_RS17410	COG0277	FAD linked oxidase domain protein
BI315_RS17415	COG1988	membrane-bound metal-dependent
BI315_RS17420	COG0792	nuclease activity
BI315_RS17455	COG0275	rRNA processing
BI315_RS17460	COG3116	cell division
BI315_RS17470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BI315_RS17475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BI315_RS17480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI315_RS17490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BI315_RS17495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI315_RS17500	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI315_RS17505	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BI315_RS17520	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BI315_RS17530	COG0739	heme binding
BI315_RS17535	COG0653	protein targeting
BI315_RS17540	COG0494	nUDIX hydrolase
BI315_RS17550	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI315_RS17565	COG3321	synthase
BI315_RS17565	COG0604	alcohol dehydrogenase
BI315_RS17565	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS17595	COG0366	Alpha amylase catalytic
BI315_RS17630	COG2226	methyltransferase
BI315_RS17635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BI315_RS17650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BI315_RS17695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BI315_RS17705	COG4106	trans-aconitate 2-methyltransferase activity
BI315_RS17710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI315_RS17720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI315_RS17725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI315_RS17735	COG0667	Aldo Keto reductase
BI315_RS17745	COG4771	TonB-dependent receptor
BI315_RS17765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI315_RS17770	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BI315_RS17780	COG2175	clavaminate synthase activity
BI315_RS17790	COG4181	ATPase activity
BI315_RS17805	COG0642	Histidine kinase
BI315_RS17820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BI315_RS17840	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BI315_RS17845	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BI315_RS17860	COG3829	transcription factor binding
BI315_RS17870	COG1116	anion transmembrane transporter activity
BI315_RS17875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI315_RS17885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI315_RS17890	COG0431	NADPH-dependent FMN reductase
BI315_RS17915	COG0747	negative chemotaxis
BI315_RS17925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI315_RS17935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BI315_RS17940	COG2967	ApaG domain
BI315_RS17945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BI315_RS17950	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BI315_RS17955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI315_RS17960	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BI315_RS17975	COG0123	including yeast histone deacetylase and acetoin utilization protein
BI315_RS17980	COG2096	Adenosyltransferase
BI315_RS17995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI315_RS18000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI315_RS18030	COG3384	dioxygenase
BI315_RS18035	COG0583	DNA-binding transcription factor activity
BI315_RS18050	COG1024	Enoyl-CoA hydratase
BI315_RS18070	COG3386	PFAM SMP-30 Gluconolaconase
BI315_RS18085	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BI315_RS18110	COG0697	spore germination
BI315_RS18120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI315_RS18140	COG2205	protein histidine kinase activity
BI315_RS18140	COG0784	Response regulator, receiver
BI315_RS18140	COG5002	protein histidine kinase activity
BI315_RS18145	COG2197	response regulator
BI315_RS18155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI315_RS18165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BI315_RS18170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI315_RS18180	COG0583	DNA-binding transcription factor activity
BI315_RS18185	COG3634	alkyl hydroperoxide reductase activity
BI315_RS18195	COG2890	protein-(glutamine-N5) methyltransferase activity
BI315_RS18215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI315_RS18215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI315_RS18245	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BI315_RS18275	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BI315_RS18290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI315_RS18295	COG1404	Belongs to the peptidase S8 family
BI315_RS18305	COG1404	Belongs to the peptidase S8 family
BI315_RS18310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BI315_RS18335	COG1295	ribonuclease BN
BI315_RS18340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI315_RS18360	COG0521	Mo-molybdopterin cofactor biosynthetic process
BI315_RS18370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BI315_RS18385	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BI315_RS18390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BI315_RS18400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BI315_RS18405	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BI315_RS18410	COG0193	aminoacyl-tRNA hydrolase activity
BI315_RS18415	COG0012	GTP binding
BI315_RS18435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI315_RS18450	COG0250	Participates in transcription elongation, termination and antitermination
BI315_RS18455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BI315_RS18460	COG0081	regulation of translation
BI315_RS18465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BI315_RS18470	COG0222	ribosome binding
BI315_RS18475	COG0085	RNA polymerase activity
BI315_RS18480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BI315_RS18485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BI315_RS18490	COG0049	tRNA binding
BI315_RS18495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BI315_RS18500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI315_RS18505	COG0051	transcription antitermination factor activity, RNA binding
BI315_RS18510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BI315_RS18515	COG0088	Forms part of the polypeptide exit tunnel
BI315_RS18520	COG0089	rRNA binding
BI315_RS18525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BI315_RS18530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BI315_RS18540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BI315_RS18545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BI315_RS18550	COG0255	Belongs to the universal ribosomal protein uL29 family
BI315_RS18555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BI315_RS18565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BI315_RS18570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BI315_RS18580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BI315_RS18585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BI315_RS18590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BI315_RS18600	COG1841	ribosomal large subunit assembly
BI315_RS18605	COG0200	Binds to the 23S rRNA
BI315_RS18610	COG0201	protein transport
BI315_RS18635	COG0203	ribosomal protein L17
BI315_RS18640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BI315_RS18660	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BI315_RS18670	COG0154	amidase activity
BI315_RS18680	COG1217	gtp-binding protein TYPA
BI315_RS18685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BI315_RS18690	COG0039	L-malate dehydrogenase activity
BI315_RS18695	COG0625	glutathione transferase activity
BI315_RS18710	COG1902	pentaerythritol trinitrate reductase activity
BI315_RS18710	COG0446	pyridine nucleotide-disulphide oxidoreductase
BI315_RS18715	COG0604	alcohol dehydrogenase
BI315_RS18745	COG0156	8-amino-7-oxononanoate synthase activity
BI315_RS18750	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BI315_RS18755	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BI315_RS18760	COG4208	sulfate ABC transporter
BI315_RS18765	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BI315_RS18775	COG1063	alcohol dehydrogenase
BI315_RS18805	COG0406	alpha-ribazole phosphatase activity
BI315_RS18810	COG0285	dihydrofolate synthase activity
BI315_RS18830	COG2833	Protein of unknown function (DUF455)
BI315_RS18840	COG3291	Pkd domain containing protein
BI315_RS18850	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI315_RS18855	COG0671	phosphoesterase, PA-phosphatase related
BI315_RS18860	COG0438	transferase activity, transferring glycosyl groups
BI315_RS18870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BI315_RS18885	COG4783	chaperone-mediated protein folding
BI315_RS18900	COG0473	3-isopropylmalate dehydrogenase activity
BI315_RS18930	COG2801	Transposase and inactivated derivatives
BI315_RS19035	COG2801	Transposase and inactivated derivatives
BI315_RS19060	COG0544	peptidyl-prolyl cis-trans isomerase activity
BI315_RS19070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BI315_RS19095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI315_RS19105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI315_RS19115	COG0328	RNA-DNA hybrid ribonuclease activity
BI315_RS19120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI315_RS19125	COG0631	protein serine/threonine phosphatase activity
BI315_RS19140	COG0859	PFAM glycosyl transferase family 9
BI315_RS19145	COG3642	lipopolysaccharide core region biosynthetic process
BI315_RS19150	COG1234	tRNA 3'-trailer cleavage
BI315_RS19155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BI315_RS19165	COG0315	cyclic pyranopterin monophosphate synthase activity
BI315_RS19170	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BI315_RS19175	COG0314	molybdopterin synthase activity
BI315_RS19240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BI315_RS19245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BI315_RS19250	COG0537	adenosine 5'-monophosphoramidase activity
BI315_RS19270	COG0714	Associated with various cellular activities
BI315_RS19295	COG0424	maF-like protein
BI315_RS19300	COG1399	metal-binding, possibly nucleic acid-binding protein
BI315_RS19305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BI315_RS19310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI315_RS19325	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS19340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BI315_RS19345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BI315_RS19370	COG3829	transcription factor binding
BI315_RS19390	COG3609	addiction module antidote protein, CC2985 family
BI315_RS19420	COG2373	Large extracellular alpha-helical protein
BI315_RS19440	COG4953	penicillin-binding protein 1C
BI315_RS19450	COG0678	peroxiredoxin activity
BI315_RS19470	COG0330	HflC and HflK could
BI315_RS19475	COG0330	HflC and HflK could
BI315_RS19490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BI315_RS19495	COG0308	aminopeptidase N
BI315_RS19500	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS19505	COG1309	transcriptional regulator
BI315_RS19550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BI315_RS19585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI315_RS19595	COG3387	PFAM Glycoside hydrolase 15-related
BI315_RS19600	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_RS19610	COG3537	Alpha-1,2-mannosidase
BI315_RS19630	COG0492	ferredoxin-NADP+ reductase activity
BI315_RS19655	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI315_RS19660	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI315_RS19665	COG2080	2 iron, 2 sulfur cluster binding
BI315_RS19700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI315_RS19715	COG0587	DNA-directed DNA polymerase activity
BI315_RS19735	COG1297	OPT oligopeptide transporter protein
BI315_RS19750	COG1506	peptidase
BI315_RS19750	COG0823	Involved in the tonB-independent uptake of proteins
BI315_RS19770	COG1917	Cupin 2, conserved barrel domain protein
BI315_RS19770	COG2207	Transcriptional regulator
BI315_RS19785	COG0753	catalase activity
BI315_RS19790	COG0656	L-ascorbic acid biosynthetic process
BI315_RS19800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI315_RS19800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI315_RS19805	COG2814	Major facilitator Superfamily
BI315_RS19820	COG2194	sulfuric ester hydrolase activity
BI315_RS19835	COG0745	RESPONSE REGULATOR receiver
BI315_RS19840	COG0642	Histidine kinase
BI315_RS19850	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BI315_RS19855	COG2894	cell division
BI315_RS19860	COG0850	regulation of cytokinetic process
BI315_RS19875	COG4585	Histidine kinase
BI315_RS19880	COG2197	response regulator
BI315_RS19895	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BI315_RS19925	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BI315_RS19935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BI315_RS19955	COG1946	Acyl-CoA thioesterase
BI315_RS19970	COG0824	Thioesterase
BI315_RS19975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BI315_RS19980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BI315_RS19985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BI315_RS19990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BI315_RS19995	COG0268	Binds directly to 16S ribosomal RNA
BI315_RS20005	COG0196	riboflavin kinase activity
BI315_RS20010	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BI315_RS20015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BI315_RS20020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BI315_RS20035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BI315_RS20040	COG1845	cytochrome c oxidase, subunit III
BI315_RS20045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BI315_RS20060	COG3152	Membrane
BI315_RS20070	COG2207	Transcriptional regulator
BI315_RS20075	COG0326	Molecular chaperone. Has ATPase activity
BI315_RS20090	COG1366	Belongs to the anti-sigma-factor antagonist family
BI315_RS20095	COG1366	Belongs to the anti-sigma-factor antagonist family
BI315_RS20100	COG2172	sigma factor antagonist activity
BI315_RS20125	COG4771	TonB-dependent receptor
BI315_RS20135	COG5507	3-demethylubiquinone-9 3-methyltransferase
BI315_RS20140	COG2205	protein histidine kinase activity
BI315_RS20150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI315_RS20155	COG2205	protein histidine kinase activity
BI315_RS20155	COG4999	Histidine kinase
BI315_RS20155	COG3437	response regulator, receiver
BI315_RS20155	COG3850	Histidine kinase
BI315_RS20160	COG0784	Response regulator, receiver
BI315_RS20160	COG4191	Histidine kinase
BI315_RS20185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI315_RS20190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BI315_RS20200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI315_RS20205	COG0228	four-way junction DNA binding
BI315_RS20210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BI315_RS20215	COG0336	Belongs to the RNA methyltransferase TrmD family
BI315_RS20220	COG0335	large ribosomal subunit rRNA binding
BI315_RS20245	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BI315_RS20255	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BI315_RS20275	COG3209	COG3209 Rhs family protein
BI315_RS20300	COG3250	beta-galactosidase activity
BI315_RS20305	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BI315_RS20325	COG1960	acyl-CoA dehydrogenase activity
BI315_RS20330	COG1024	Enoyl-CoA hydratase
BI315_RS20350	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI315_RS20350	COG1024	Enoyl-CoA hydratase
BI315_RS20365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI315_RS20370	COG0481	GTPase activity
BI315_RS20385	COG0571	ribonuclease III activity
BI315_RS20390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BI315_RS20395	COG1381	Involved in DNA repair and RecF pathway recombination
BI315_RS20405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI315_RS20410	COG2954	triphosphatase activity
BI315_RS20415	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BI315_RS20420	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BI315_RS20425	COG3046	protein related to deoxyribodipyrimidine photolyase
BI315_RS20430	COG1472	Belongs to the glycosyl hydrolase 3 family
BI315_RS20435	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BI315_RS20440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BI315_RS20445	COG1278	Cold shock
BI315_RS20450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI315_RS20460	COG1201	RNA secondary structure unwinding
BI315_RS20465	COG1793	dna ligase
BI315_RS20475	COG1793	dna ligase
BI315_RS20475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BI315_RS20510	COG0183	Belongs to the thiolase family
BI315_RS20535	COG1451	nucleotide metabolic process
BI315_RS20540	COG5487	UPF0391 membrane protein
BI315_RS20550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BI315_RS20565	COG1077	Cell shape determining protein MreB Mrl
BI315_RS20570	COG1047	Peptidyl-prolyl cis-trans
BI315_RS20580	COG2824	Alkylphosphonate utilization operon protein PhnA
BI315_RS20590	COG1902	pentaerythritol trinitrate reductase activity
BI315_RS20595	COG2814	Major facilitator Superfamily
BI315_RS20630	COG0392	lysyltransferase activity
BI315_RS20630	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BI315_RS20640	COG0251	oxidation-reduction process
BI315_RS20645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI315_RS20660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI315_RS20685	COG1595	DNA-templated transcription, initiation
BI315_RS20705	COG2878	Part of a membrane complex involved in electron transport
BI315_RS20715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI315_RS20715	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI315_RS20730	COG1131	(ABC) transporter
BI315_RS20735	COG0346	lactoylglutathione lyase activity
BI315_RS20740	COG0833	amino acid
BI315_RS20745	COG2040	homocysteine
BI315_RS20755	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI315_RS20775	COG1695	Transcriptional regulator
BI315_RS20795	COG1981	membrane
BI315_RS20810	COG0825	malonyl-CoA metabolic process
BI315_RS20820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BI315_RS20825	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI315_RS20830	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI315_RS20835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI315_RS20840	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI315_RS20855	COG0750	zinc metalloprotease
BI315_RS20860	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BI315_RS20865	COG0575	Belongs to the CDS family
BI315_RS20870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BI315_RS20875	COG0233	cytoplasmic translational termination
BI315_RS20880	COG0528	UMP kinase activity
BI315_RS20890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BI315_RS20895	COG0052	Belongs to the universal ribosomal protein uS2 family
BI315_RS20935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BI315_RS20945	COG1393	Belongs to the ArsC family
BI315_RS20950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI315_RS20955	COG0367	asparagine synthase
BI315_RS20965	COG4774	siderophore transport
BI315_RS20985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI315_RS21015	COG1566	PFAM secretion protein HlyD family protein
BI315_RS21020	COG2814	Major facilitator Superfamily
BI315_RS21070	COG0339	signal peptide processing
BI315_RS21080	COG0386	Belongs to the glutathione peroxidase family
BI315_RS21135	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BI315_RS21140	COG0084	hydrolase, TatD family'
BI315_RS21155	COG1960	acyl-CoA dehydrogenase activity
BI315_RS21175	COG0367	asparagine synthase
BI315_RS21185	COG0305	Participates in initiation and elongation during chromosome replication
BI315_RS21190	COG0415	Belongs to the DNA photolyase family
BI315_RS21215	COG0583	DNA-binding transcription factor activity
BI315_RS21260	COG3706	GGDEF domain
BI315_RS21385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BI315_RS21400	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI315_RS21410	COG0497	DNA recombination
BI315_RS21415	COG1420	regulation of RNA biosynthetic process
BI315_RS21420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BI315_RS21425	COG0443	Heat shock 70 kDa protein
BI315_RS21430	COG0484	heat shock protein binding
BI315_RS21440	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BI315_RS21470	COG0583	DNA-binding transcription factor activity
BI315_RS21475	COG1132	(ABC) transporter
BI315_RS21510	COG2850	peptidyl-arginine hydroxylation
BI315_RS21530	COG1253	flavin adenine dinucleotide binding
BI315_RS21560	COG1131	(ABC) transporter
BI315_RS21565	COG1725	Transcriptional regulator
BI315_RS21575	COG0386	Belongs to the glutathione peroxidase family
BI315_RS21590	COG2900	Belongs to the SlyX family
BI315_RS21615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI315_RS21625	COG1410	methionine synthase
BI315_RS21625	COG0646	methionine synthase
BI315_RS21630	COG0646	methionine synthase
BI315_RS21630	COG1410	methionine synthase
BI315_RS21635	COG2226	methyltransferase
BI315_RS21640	COG1960	acyl-CoA dehydrogenase activity
BI315_RS21645	COG1960	acyl-CoA dehydrogenase activity
BI315_RS21650	COG1960	acyl-CoA dehydrogenase activity
BI315_RS21655	COG1960	acyl-CoA dehydrogenase activity
BI315_RS21675	COG0557	exoribonuclease II activity
BI315_RS21685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI315_RS21695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI315_RS21705	COG0704	Plays a role in the regulation of phosphate uptake
BI315_RS21710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BI315_RS21715	COG0581	inorganic phosphate transmembrane transporter activity
BI315_RS21720	COG0573	inorganic phosphate transmembrane transporter activity
BI315_RS21725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BI315_RS21750	COG0659	secondary active sulfate transmembrane transporter activity
BI315_RS21755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BI315_RS21765	COG1024	Enoyl-CoA hydratase
BI315_RS21775	COG0494	nUDIX hydrolase
BI315_RS21810	COG0488	(ABC) transporter
BI315_RS21820	COG0116	Belongs to the methyltransferase superfamily
BI315_RS21820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BI315_RS21825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BI315_RS21850	COG2925	Exonuclease
BI315_RS21860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI315_RS21865	COG3844	kynureninase activity
BI315_RS21875	COG0662	Cupin 2, conserved barrel domain protein
BI315_RS21880	COG0288	reversible hydration of carbon dioxide
BI315_RS21945	COG2808	Putative FMN-binding domain
BI315_RS21965	COG0017	Asparaginyl-tRNA synthetase
BI315_RS21975	COG0316	Belongs to the HesB IscA family
BI315_RS21980	COG0360	Binds together with S18 to 16S ribosomal RNA
BI315_RS21985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BI315_RS21990	COG0359	binds to the 23S rRNA
BI315_RS22000	COG3115	cell septum assembly
BI315_RS22010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI315_RS22015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BI315_RS22020	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BI315_RS22035	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BI315_RS22045	COG4993	Dehydrogenase
BI315_RS22055	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BI315_RS22065	COG2986	histidine ammonia-lyase
BI315_RS22070	COG1228	amidohydrolase
BI315_RS22115	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BI315_RS22120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BI315_RS22125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BI315_RS22130	COG1605	Chorismate mutase
BI315_RS22130	COG0077	Prephenate dehydratase
BI315_RS22135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BI315_RS22150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BI315_RS22155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI315_RS22160	COG0583	DNA-binding transcription factor activity
BI315_RS22220	COG0840	transmembrane signaling receptor activity
BI315_RS22255	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BI315_RS22260	COG0784	Response regulator, receiver
BI315_RS22260	COG4191	Histidine kinase
BI315_RS22275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI315_RS22285	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BI315_RS22295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI315_RS22310	COG1595	DNA-templated transcription, initiation
BI315_RS22365	COG2244	polysaccharide biosynthetic process
BI315_RS22400	COG2264	protein methyltransferase activity
BI315_RS22410	COG0438	transferase activity, transferring glycosyl groups
BI315_RS22425	COG1136	(ABC) transporter
BI315_RS22435	COG0477	Major facilitator Superfamily
BI315_RS22440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI315_RS22455	COG1253	flavin adenine dinucleotide binding
BI315_RS22470	COG0306	phosphate transporter
BI315_RS22495	COG0504	CTP synthase activity
BI315_RS22500	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BI315_RS22510	COG0148	phosphopyruvate hydratase activity
BI315_RS22515	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BI315_RS22520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BI315_RS22525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BI315_RS22530	COG0585	pseudouridine synthase activity
BI315_RS22535	COG2840	Smr protein MutS2
BI315_RS22540	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BI315_RS22545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI315_RS22550	COG1238	metal cluster binding
BI315_RS22565	COG1534	Rna-binding protein
BI315_RS22570	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BI315_RS22580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BI315_RS22585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI315_RS22595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BI315_RS22600	COG1546	Belongs to the CinA family
BI315_RS22610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI315_RS22615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BI315_RS22625	COG2137	regulation of response to DNA damage stimulus
BI315_RS22630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BI315_RS22635	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BI315_RS22655	COG1741	Belongs to the pirin family
BI315_RS22660	COG0583	DNA-binding transcription factor activity
BI315_RS22685	COG0351	phosphomethylpyrimidine kinase
BI315_RS22685	COG0352	thiamine-phosphate diphosphorylase activity
BI315_RS22700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BI315_RS22705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BI315_RS22720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI315_RS22730	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BI315_RS22735	COG3734	2-keto-3-deoxy-galactonokinase
BI315_RS22745	COG4948	Mandelate Racemase Muconate Lactonizing
BI315_RS22750	COG0800	Aldolase
BI315_RS22790	COG1501	Belongs to the glycosyl hydrolase 31 family
BI315_RS22800	COG1070	Carbohydrate kinase
BI315_RS22805	COG2115	Belongs to the xylose isomerase family
BI315_RS22810	COG0477	Major facilitator Superfamily
BI315_RS22830	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI315_RS22835	COG1469	GTP cyclohydrolase I activity
BI315_RS22855	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BI315_RS22860	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BI315_RS22865	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BI315_RS22870	COG0166	Belongs to the GPI family
BI315_RS22895	COG1472	Belongs to the glycosyl hydrolase 3 family
BI315_RS22910	COG2203	Gaf domain
BI315_RS22910	COG5001	Diguanylate cyclase
BI315_RS22910	COG3706	GGDEF domain
BI315_RS22910	COG4251	negative regulation of phosphorylation
BI315_RS22920	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI315_RS22925	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BI315_RS22940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BI315_RS22945	COG0671	phosphoesterase, PA-phosphatase related
BI315_RS22960	COG1794	racemase activity, acting on amino acids and derivatives
BI315_RS22965	COG0697	spore germination
BI315_RS22970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BI315_RS22975	COG0167	dihydroorotate dehydrogenase activity
BI315_RS22995	COG1012	belongs to the aldehyde dehydrogenase family
BI315_RS23010	COG1215	transferase activity, transferring glycosyl groups
BI315_RS23015	COG1649	PFAM Uncharacterised BCR, COG1649
BI315_RS23015	COG0726	polysaccharide deacetylase
BI315_RS23030	COG3210	domain, Protein
BI315_RS23040	COG3210	domain, Protein
BI315_RS23085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI315_RS23090	COG0124	histidyl-tRNA synthetase
BI315_RS23100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BI315_RS23105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BI315_RS23110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI315_RS23115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BI315_RS23115	COG0131	Imidazoleglycerol-phosphate dehydratase
BI315_RS23120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BI315_RS23125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BI315_RS23130	COG0107	imidazoleglycerol-phosphate synthase activity
BI315_RS23135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BI315_RS23135	COG0140	phosphoribosyl-ATP diphosphatase activity
BI315_RS23150	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BI315_RS23155	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BI315_RS23160	COG0235	Class ii aldolase
BI315_RS23165	COG0531	amino acid
BI315_RS23170	COG0531	amino acid
BI315_RS23180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI315_RS23185	COG0277	FAD linked oxidase domain protein
BI315_RS23205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI315_RS23250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI315_RS23255	COG2258	MOSC domain
BI315_RS23260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BI315_RS23265	COG0505	Belongs to the CarA family
BI315_RS23275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BI315_RS23280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI315_RS23290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BI315_RS23330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BI315_RS23355	COG2198	Histidine kinase
BI315_RS23355	COG2205	protein histidine kinase activity
BI315_RS23355	COG0784	Response regulator, receiver
BI315_RS23360	COG2198	Histidine kinase
BI315_RS23360	COG0784	Response regulator, receiver
BI315_RS23360	COG2205	protein histidine kinase activity
BI315_RS23565	COG0840	transmembrane signaling receptor activity
BI315_RS23805	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI315_RS24180	COG0492	ferredoxin-NADP+ reductase activity
BI315_RS24285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BI315_RS24755	COG0840	transmembrane signaling receptor activity