locus-tag	class	description
AMD18_RS00150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AMD18_RS00170	COG1192	Involved in chromosome partitioning
AMD18_RS00205	COG2951	lytic endotransglycosylase activity
AMD18_RS00210	COG4644	lycopene metabolic process
AMD18_RS00340	COG2948	multi-organism process
AMD18_RS00345	COG3504	Conjugal transfer protein
AMD18_RS00450	COG4456	Virulence-associated protein
AMD18_RS00455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AMD18_RS00485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AMD18_RS00500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AMD18_RS00510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMD18_RS00515	COG0187	DNA topoisomerase II activity
AMD18_RS00525	COG0501	Belongs to the peptidase M48B family
AMD18_RS00555	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMD18_RS00565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD18_RS00610	COG0793	Belongs to the peptidase S41A family
AMD18_RS00615	COG4942	peptidase
AMD18_RS00625	COG2234	aminopeptidase activity
AMD18_RS00635	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD18_RS00640	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD18_RS00645	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD18_RS00650	COG1064	alcohol dehydrogenase
AMD18_RS00655	COG0493	'glutamate synthase
AMD18_RS00660	COG0067	glutamate synthase
AMD18_RS00660	COG0070	glutamate synthase
AMD18_RS00660	COG0069	glutamate synthase activity
AMD18_RS00705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AMD18_RS00720	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AMD18_RS00725	COG0438	transferase activity, transferring glycosyl groups
AMD18_RS00725	COG0297	glycogen (starch) synthase activity
AMD18_RS00745	COG0367	asparagine synthase
AMD18_RS00775	COG1132	(ABC) transporter
AMD18_RS00805	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AMD18_RS00885	COG1111	helicase
AMD18_RS00885	COG1205	dead DEAH box helicase
AMD18_RS00890	COG1272	protein, Hemolysin III
AMD18_RS00905	COG0300	oxidoreductase activity
AMD18_RS00910	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS00930	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMD18_RS00990	COG3237	CsbD-like
AMD18_RS01040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD18_RS01050	COG0477	Major facilitator Superfamily
AMD18_RS01090	COG0714	Associated with various cellular activities
AMD18_RS01120	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AMD18_RS01130	COG4772	TonB-dependent receptor
AMD18_RS01140	COG0662	Cupin 2, conserved barrel domain protein
AMD18_RS01145	COG1012	belongs to the aldehyde dehydrogenase family
AMD18_RS01170	COG1304	FMN binding
AMD18_RS01185	COG4585	Histidine kinase
AMD18_RS01190	COG2197	response regulator
AMD18_RS01210	COG3710	Transcriptional regulator
AMD18_RS01215	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMD18_RS01290	COG0366	Alpha amylase catalytic
AMD18_RS01295	COG0366	Alpha amylase catalytic
AMD18_RS01300	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMD18_RS01320	COG2755	lipolytic protein G-D-S-L family
AMD18_RS01320	COG0657	acetylesterase activity
AMD18_RS01330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMD18_RS01345	COG3507	Belongs to the glycosyl hydrolase 43 family
AMD18_RS01350	COG1609	Transcriptional regulator
AMD18_RS01355	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AMD18_RS01360	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS01370	COG2755	lipolytic protein G-D-S-L family
AMD18_RS01385	COG3186	Phenylalanine-4-hydroxylase
AMD18_RS01390	COG1522	sequence-specific DNA binding
AMD18_RS01400	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMD18_RS01410	COG1119	ATPase activity
AMD18_RS01425	COG1125	glycine betaine transport
AMD18_RS01440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMD18_RS01460	COG1396	sequence-specific DNA binding
AMD18_RS01485	COG0489	protein tyrosine kinase activity
AMD18_RS01490	COG2062	phosphohistidine phosphatase, SixA
AMD18_RS01500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD18_RS01545	COG1968	undecaprenyl-diphosphatase activity
AMD18_RS01550	COG0174	glutamine synthetase
AMD18_RS01555	COG0347	Belongs to the P(II) protein family
AMD18_RS01560	COG0004	ammonium transporteR
AMD18_RS01565	COG3852	Histidine kinase
AMD18_RS01570	COG2204	response regulator
AMD18_RS01575	COG2032	superoxide dismutase activity
AMD18_RS01580	COG2032	superoxide dismutase activity
AMD18_RS01585	COG0346	lactoylglutathione lyase activity
AMD18_RS01595	COG0183	Belongs to the thiolase family
AMD18_RS01630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AMD18_RS01635	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AMD18_RS01640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMD18_RS01650	COG0028	Belongs to the TPP enzyme family
AMD18_RS01655	COG2205	protein histidine kinase activity
AMD18_RS01680	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AMD18_RS01695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD18_RS01705	COG0596	Alpha beta hydrolase
AMD18_RS01710	COG0727	PFAM Uncharacterised protein family (UPF0153)
AMD18_RS01715	COG0318	PFAM AMP-dependent synthetase and ligase
AMD18_RS01720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD18_RS01735	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMD18_RS01745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMD18_RS01755	COG0564	pseudouridine synthase activity
AMD18_RS01780	COG0339	signal peptide processing
AMD18_RS01810	COG0475	glutathione-regulated potassium exporter activity
AMD18_RS01815	COG0583	DNA-binding transcription factor activity
AMD18_RS01820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AMD18_RS01825	COG2224	Isocitrate lyase
AMD18_RS01855	COG4770	biotin carboxylase activity
AMD18_RS01860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMD18_RS01865	COG1960	acyl-CoA dehydrogenase activity
AMD18_RS01920	COG0523	cobalamin synthesis protein
AMD18_RS01935	COG0697	spore germination
AMD18_RS01945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AMD18_RS01950	COG1846	Transcriptional regulator
AMD18_RS01955	COG1764	response to oxidative stress
AMD18_RS01985	COG2130	NADP-dependent
AMD18_RS02000	COG1187	pseudouridine synthase activity
AMD18_RS02015	COG1643	Atp-dependent helicase
AMD18_RS02025	COG4807	Protein conserved in bacteria
AMD18_RS02030	COG2351	hydroxyisourate hydrolase activity
AMD18_RS02035	COG2072	flavoprotein involved in K transport
AMD18_RS02055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AMD18_RS02100	COG2252	PERMEase
AMD18_RS02125	COG0084	hydrolase, TatD family'
AMD18_RS02140	COG0583	DNA-binding transcription factor activity
AMD18_RS02145	COG2814	Major facilitator Superfamily
AMD18_RS02160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMD18_RS02165	COG1902	pentaerythritol trinitrate reductase activity
AMD18_RS02185	COG0745	RESPONSE REGULATOR receiver
AMD18_RS02190	COG2205	protein histidine kinase activity
AMD18_RS02195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD18_RS02215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMD18_RS02220	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMD18_RS02225	COG0583	DNA-binding transcription factor activity
AMD18_RS02255	COG0702	epimerase
AMD18_RS02260	COG1733	regulation of RNA biosynthetic process
AMD18_RS02300	COG0129	dihydroxy-acid dehydratase activity
AMD18_RS02320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AMD18_RS02375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMD18_RS02380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AMD18_RS02405	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMD18_RS02410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMD18_RS02420	COG3485	protocatechuate 3,4-dioxygenase
AMD18_RS02425	COG3485	protocatechuate 3,4-dioxygenase
AMD18_RS02435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD18_RS02440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMD18_RS02450	COG1414	Transcriptional regulator
AMD18_RS02460	COG0657	acetylesterase activity
AMD18_RS02470	COG0445	tRNA wobble uridine modification
AMD18_RS02480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMD18_RS02510	COG2267	carboxylic ester hydrolase activity
AMD18_RS02520	COG0156	8-amino-7-oxononanoate synthase activity
AMD18_RS02525	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AMD18_RS02530	COG1040	competence protein
AMD18_RS02535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMD18_RS02610	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AMD18_RS02680	COG1511	domain protein
AMD18_RS02680	COG3264	Mechanosensitive ion channel
AMD18_RS02685	COG1368	sulfuric ester hydrolase activity
AMD18_RS02690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMD18_RS02695	COG2354	Protein conserved in bacteria
AMD18_RS02705	COG0297	glycogen (starch) synthase activity
AMD18_RS02710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMD18_RS02715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMD18_RS02740	COG0702	epimerase
AMD18_RS02745	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS02780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD18_RS02785	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS02795	COG0513	Belongs to the DEAD box helicase family
AMD18_RS02815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMD18_RS02825	COG3483	tryptophan 2,3-dioxygenase activity
AMD18_RS02830	COG3104	oligopeptide transport
AMD18_RS02850	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AMD18_RS02865	COG1320	monovalent cation:proton antiporter activity
AMD18_RS02870	COG2212	antiporter activity
AMD18_RS02880	COG0651	ATP synthesis coupled electron transport
AMD18_RS02885	COG1006	Multisubunit Na H antiporter MnhC subunit
AMD18_RS02890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMD18_RS02890	COG2111	Na H antiporter
AMD18_RS02910	COG3179	chitinase
AMD18_RS02930	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMD18_RS02935	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AMD18_RS02950	COG0456	acetyltransferase
AMD18_RS02955	COG1597	lipid kinase activity
AMD18_RS02980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMD18_RS02985	COG0134	indole-3-glycerol-phosphate synthase activity
AMD18_RS02995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD18_RS03000	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMD18_RS03010	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AMD18_RS03020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMD18_RS03035	COG1051	belongs to the nudix hydrolase family
AMD18_RS03075	COG0316	Belongs to the HesB IscA family
AMD18_RS03100	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMD18_RS03120	COG2814	Major facilitator Superfamily
AMD18_RS03125	COG0583	DNA-binding transcription factor activity
AMD18_RS03130	COG2814	Major facilitator Superfamily
AMD18_RS03135	COG1289	transmembrane transporter activity
AMD18_RS03145	COG0151	Belongs to the GarS family
AMD18_RS03155	COG0138	bifunctional purine biosynthesis protein purh
AMD18_RS03160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD18_RS03165	COG2267	carboxylic ester hydrolase activity
AMD18_RS03170	COG0671	phosphoesterase, PA-phosphatase related
AMD18_RS03170	COG2453	phosphatase
AMD18_RS03195	COG4589	Belongs to the CDS family
AMD18_RS03200	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AMD18_RS03225	COG2264	protein methyltransferase activity
AMD18_RS03240	COG0439	Biotin carboxylase
AMD18_RS03250	COG0511	ligase activity, forming carbon-carbon bonds
AMD18_RS03255	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMD18_RS03265	COG1324	tolerance protein
AMD18_RS03290	COG0300	oxidoreductase activity
AMD18_RS03295	COG2356	endonuclease I
AMD18_RS03305	COG0459	protein refolding
AMD18_RS03320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AMD18_RS03335	COG3386	PFAM SMP-30 Gluconolaconase
AMD18_RS03345	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMD18_RS03350	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AMD18_RS03370	COG0778	Nitroreductase
AMD18_RS03375	COG2353	YceI-like domain
AMD18_RS03405	COG3052	prosthetic group binding
AMD18_RS03430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMD18_RS03440	COG1802	Transcriptional regulator
AMD18_RS03495	COG4221	oxidoreductase activity
AMD18_RS03510	COG4221	oxidoreductase activity
AMD18_RS03520	COG0435	Glutathione S-transferase
AMD18_RS03545	COG2409	Drug exporters of the RND superfamily
AMD18_RS03550	COG0823	Involved in the tonB-independent uptake of proteins
AMD18_RS03550	COG1506	peptidase
AMD18_RS03590	COG0697	spore germination
AMD18_RS03605	COG1113	amino acid transport
AMD18_RS03625	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AMD18_RS03660	COG5001	Diguanylate cyclase
AMD18_RS03665	COG0840	transmembrane signaling receptor activity
AMD18_RS03670	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD18_RS03670	COG5297	Belongs to the glycosyl hydrolase family 6
AMD18_RS03675	COG0659	secondary active sulfate transmembrane transporter activity
AMD18_RS03695	COG2943	transferase activity, transferring hexosyl groups
AMD18_RS03705	COG3275	phosphorelay sensor kinase activity
AMD18_RS03715	COG0181	hydroxymethylbilane synthase activity
AMD18_RS03740	COG1505	serine-type exopeptidase activity
AMD18_RS03745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMD18_RS03750	COG0436	Aminotransferase
AMD18_RS03760	COG2832	Protein of unknown function (DUF454)
AMD18_RS03770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AMD18_RS03780	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AMD18_RS03785	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AMD18_RS03790	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AMD18_RS03815	COG2226	methyltransferase
AMD18_RS03820	COG3300	MHYT domain
AMD18_RS03820	COG5001	Diguanylate cyclase
AMD18_RS03825	COG0308	aminopeptidase N
AMD18_RS03875	COG3284	Transcriptional regulator
AMD18_RS03880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD18_RS03885	COG1077	Cell shape determining protein MreB Mrl
AMD18_RS03890	COG1792	Involved in formation and maintenance of cell shape
AMD18_RS03905	COG0772	Belongs to the SEDS family
AMD18_RS03915	COG2951	lytic endotransglycosylase activity
AMD18_RS03920	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AMD18_RS03930	COG1686	Belongs to the peptidase S11 family
AMD18_RS03940	COG2921	Belongs to the UPF0250 family
AMD18_RS03945	COG0321	lipoyl(octanoyl) transferase activity
AMD18_RS03950	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMD18_RS03965	COG0583	DNA-binding transcription factor activity
AMD18_RS03975	COG1056	cytidyltransferase-related domain
AMD18_RS03975	COG1051	belongs to the nudix hydrolase family
AMD18_RS04010	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AMD18_RS04015	COG0673	inositol 2-dehydrogenase activity
AMD18_RS04020	COG2823	Periplasmic or secreted lipoprotein
AMD18_RS04025	COG4251	negative regulation of phosphorylation
AMD18_RS04030	COG0784	Response regulator, receiver
AMD18_RS04035	COG4191	Histidine kinase
AMD18_RS04040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AMD18_RS04095	COG1459	type II secretion system
AMD18_RS04160	COG2188	Transcriptional regulator
AMD18_RS04170	COG1609	Transcriptional regulator
AMD18_RS04175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMD18_RS04180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AMD18_RS04190	COG0617	tRNA 3'-terminal CCA addition
AMD18_RS04195	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AMD18_RS04200	COG1012	belongs to the aldehyde dehydrogenase family
AMD18_RS04205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AMD18_RS04215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMD18_RS04230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AMD18_RS04235	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AMD18_RS04280	COG3791	Glutathione-dependent formaldehyde-activating
AMD18_RS04295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMD18_RS04305	COG0697	spore germination
AMD18_RS04315	COG0488	(ABC) transporter
AMD18_RS04325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMD18_RS04330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMD18_RS04340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMD18_RS04340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMD18_RS04360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMD18_RS04365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMD18_RS04370	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AMD18_RS04390	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AMD18_RS04395	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AMD18_RS04400	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AMD18_RS04405	COG2205	protein histidine kinase activity
AMD18_RS04410	COG0745	RESPONSE REGULATOR receiver
AMD18_RS04425	COG0277	FAD linked oxidase domain protein
AMD18_RS04430	COG1988	membrane-bound metal-dependent
AMD18_RS04435	COG0792	nuclease activity
AMD18_RS04465	COG0275	rRNA processing
AMD18_RS04470	COG3116	cell division
AMD18_RS04480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMD18_RS04485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMD18_RS04490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMD18_RS04500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMD18_RS04505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMD18_RS04510	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMD18_RS04515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AMD18_RS04530	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AMD18_RS04540	COG0739	heme binding
AMD18_RS04545	COG0653	protein targeting
AMD18_RS04550	COG0494	nUDIX hydrolase
AMD18_RS04560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMD18_RS04570	COG0604	alcohol dehydrogenase
AMD18_RS04570	COG3321	synthase
AMD18_RS04570	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS04590	COG0366	Alpha amylase catalytic
AMD18_RS04620	COG2226	methyltransferase
AMD18_RS04625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AMD18_RS04635	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AMD18_RS04670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMD18_RS04680	COG4106	trans-aconitate 2-methyltransferase activity
AMD18_RS04685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMD18_RS04695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD18_RS04700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AMD18_RS04705	COG0667	Aldo Keto reductase
AMD18_RS04715	COG4771	TonB-dependent receptor
AMD18_RS04735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD18_RS04740	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AMD18_RS04750	COG2175	clavaminate synthase activity
AMD18_RS04760	COG4181	ATPase activity
AMD18_RS04775	COG0642	Histidine kinase
AMD18_RS04785	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AMD18_RS04805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMD18_RS04810	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AMD18_RS04825	COG3829	transcription factor binding
AMD18_RS04835	COG1116	anion transmembrane transporter activity
AMD18_RS04840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD18_RS04850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD18_RS04855	COG0431	NADPH-dependent FMN reductase
AMD18_RS04880	COG0747	negative chemotaxis
AMD18_RS04890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMD18_RS04900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AMD18_RS04905	COG2967	ApaG domain
AMD18_RS04910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMD18_RS04915	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AMD18_RS04920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD18_RS04925	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AMD18_RS04935	COG0123	including yeast histone deacetylase and acetoin utilization protein
AMD18_RS04940	COG2096	Adenosyltransferase
AMD18_RS04950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD18_RS04955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD18_RS04985	COG3384	dioxygenase
AMD18_RS04990	COG0583	DNA-binding transcription factor activity
AMD18_RS05005	COG1024	Enoyl-CoA hydratase
AMD18_RS05025	COG3386	PFAM SMP-30 Gluconolaconase
AMD18_RS05035	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AMD18_RS05060	COG0697	spore germination
AMD18_RS05070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD18_RS05090	COG0784	Response regulator, receiver
AMD18_RS05090	COG5002	protein histidine kinase activity
AMD18_RS05090	COG2205	protein histidine kinase activity
AMD18_RS05095	COG2197	response regulator
AMD18_RS05105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMD18_RS05115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMD18_RS05120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD18_RS05125	COG0583	DNA-binding transcription factor activity
AMD18_RS05130	COG3634	alkyl hydroperoxide reductase activity
AMD18_RS05140	COG2890	protein-(glutamine-N5) methyltransferase activity
AMD18_RS05160	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD18_RS05160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD18_RS05190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AMD18_RS05220	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AMD18_RS05235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMD18_RS05240	COG1404	Belongs to the peptidase S8 family
AMD18_RS05250	COG1404	Belongs to the peptidase S8 family
AMD18_RS05255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMD18_RS05280	COG1295	ribonuclease BN
AMD18_RS05285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD18_RS05305	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMD18_RS05315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMD18_RS05330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AMD18_RS05335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AMD18_RS05345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AMD18_RS05350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AMD18_RS05355	COG0193	aminoacyl-tRNA hydrolase activity
AMD18_RS05360	COG0012	GTP binding
AMD18_RS05380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMD18_RS05395	COG0250	Participates in transcription elongation, termination and antitermination
AMD18_RS05400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMD18_RS05405	COG0081	regulation of translation
AMD18_RS05410	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMD18_RS05415	COG0222	ribosome binding
AMD18_RS05420	COG0085	RNA polymerase activity
AMD18_RS05425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMD18_RS05430	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMD18_RS05435	COG0049	tRNA binding
AMD18_RS05440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMD18_RS05445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMD18_RS05450	COG0051	transcription antitermination factor activity, RNA binding
AMD18_RS05455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMD18_RS05460	COG0088	Forms part of the polypeptide exit tunnel
AMD18_RS05465	COG0089	rRNA binding
AMD18_RS05470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMD18_RS05475	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMD18_RS05485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMD18_RS05490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AMD18_RS05495	COG0255	Belongs to the universal ribosomal protein uL29 family
AMD18_RS05500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMD18_RS05510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AMD18_RS05515	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMD18_RS05525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMD18_RS05530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMD18_RS05535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AMD18_RS05545	COG1841	ribosomal large subunit assembly
AMD18_RS05550	COG0200	Binds to the 23S rRNA
AMD18_RS05555	COG0201	protein transport
AMD18_RS05580	COG0203	ribosomal protein L17
AMD18_RS05585	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AMD18_RS05600	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AMD18_RS05610	COG0154	amidase activity
AMD18_RS05620	COG1217	gtp-binding protein TYPA
AMD18_RS05625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMD18_RS05630	COG0039	L-malate dehydrogenase activity
AMD18_RS05635	COG0625	glutathione transferase activity
AMD18_RS05645	COG1902	pentaerythritol trinitrate reductase activity
AMD18_RS05645	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMD18_RS05650	COG0604	alcohol dehydrogenase
AMD18_RS05675	COG0156	8-amino-7-oxononanoate synthase activity
AMD18_RS05680	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AMD18_RS05685	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AMD18_RS05690	COG4208	sulfate ABC transporter
AMD18_RS05695	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AMD18_RS05705	COG1063	alcohol dehydrogenase
AMD18_RS05735	COG0406	alpha-ribazole phosphatase activity
AMD18_RS05740	COG0285	dihydrofolate synthase activity
AMD18_RS05760	COG2833	Protein of unknown function (DUF455)
AMD18_RS05770	COG3291	Pkd domain containing protein
AMD18_RS05780	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD18_RS05785	COG0671	phosphoesterase, PA-phosphatase related
AMD18_RS05790	COG0438	transferase activity, transferring glycosyl groups
AMD18_RS05800	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AMD18_RS05815	COG4783	chaperone-mediated protein folding
AMD18_RS05830	COG0473	3-isopropylmalate dehydrogenase activity
AMD18_RS05985	COG0544	peptidyl-prolyl cis-trans isomerase activity
AMD18_RS05995	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMD18_RS06025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD18_RS06035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD18_RS06045	COG0328	RNA-DNA hybrid ribonuclease activity
AMD18_RS06050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD18_RS06055	COG0631	protein serine/threonine phosphatase activity
AMD18_RS06070	COG0859	PFAM glycosyl transferase family 9
AMD18_RS06075	COG3642	lipopolysaccharide core region biosynthetic process
AMD18_RS06080	COG1234	tRNA 3'-trailer cleavage
AMD18_RS06085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMD18_RS06095	COG0315	cyclic pyranopterin monophosphate synthase activity
AMD18_RS06100	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AMD18_RS06105	COG0314	molybdopterin synthase activity
AMD18_RS06160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMD18_RS06165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMD18_RS06170	COG0537	adenosine 5'-monophosphoramidase activity
AMD18_RS06190	COG0714	Associated with various cellular activities
AMD18_RS06210	COG0424	maF-like protein
AMD18_RS06215	COG1399	metal-binding, possibly nucleic acid-binding protein
AMD18_RS06220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMD18_RS06225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD18_RS06240	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS06255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMD18_RS06260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMD18_RS06285	COG3829	transcription factor binding
AMD18_RS06305	COG3609	addiction module antidote protein, CC2985 family
AMD18_RS06325	COG2373	Large extracellular alpha-helical protein
AMD18_RS06340	COG4953	penicillin-binding protein 1C
AMD18_RS06350	COG0678	peroxiredoxin activity
AMD18_RS06370	COG0330	HflC and HflK could
AMD18_RS06375	COG0330	HflC and HflK could
AMD18_RS06385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMD18_RS06390	COG0308	aminopeptidase N
AMD18_RS06400	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS06405	COG1309	transcriptional regulator
AMD18_RS06475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMD18_RS06485	COG3387	PFAM Glycoside hydrolase 15-related
AMD18_RS06490	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS06495	COG3537	Alpha-1,2-mannosidase
AMD18_RS06515	COG0492	ferredoxin-NADP+ reductase activity
AMD18_RS06540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMD18_RS06545	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMD18_RS06550	COG2080	2 iron, 2 sulfur cluster binding
AMD18_RS06585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMD18_RS06600	COG0587	DNA-directed DNA polymerase activity
AMD18_RS06615	COG1297	OPT oligopeptide transporter protein
AMD18_RS06630	COG1506	peptidase
AMD18_RS06630	COG0823	Involved in the tonB-independent uptake of proteins
AMD18_RS06645	COG1917	Cupin 2, conserved barrel domain protein
AMD18_RS06645	COG2207	Transcriptional regulator
AMD18_RS06660	COG0753	catalase activity
AMD18_RS06665	COG0656	L-ascorbic acid biosynthetic process
AMD18_RS06675	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMD18_RS06675	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMD18_RS06680	COG2814	Major facilitator Superfamily
AMD18_RS06695	COG2194	sulfuric ester hydrolase activity
AMD18_RS06710	COG0745	RESPONSE REGULATOR receiver
AMD18_RS06715	COG0642	Histidine kinase
AMD18_RS06725	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AMD18_RS06730	COG2894	cell division
AMD18_RS06735	COG0850	regulation of cytokinetic process
AMD18_RS06750	COG4585	Histidine kinase
AMD18_RS06755	COG2197	response regulator
AMD18_RS06770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AMD18_RS06795	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AMD18_RS06805	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AMD18_RS06825	COG1946	Acyl-CoA thioesterase
AMD18_RS06840	COG0824	Thioesterase
AMD18_RS06845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMD18_RS06850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMD18_RS06855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMD18_RS06860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMD18_RS06865	COG0268	Binds directly to 16S ribosomal RNA
AMD18_RS06875	COG0196	riboflavin kinase activity
AMD18_RS06880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMD18_RS06885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMD18_RS06890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMD18_RS06905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMD18_RS06910	COG1845	cytochrome c oxidase, subunit III
AMD18_RS06915	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AMD18_RS06930	COG3152	Membrane
AMD18_RS06940	COG2207	Transcriptional regulator
AMD18_RS06945	COG0326	Molecular chaperone. Has ATPase activity
AMD18_RS06955	COG1366	Belongs to the anti-sigma-factor antagonist family
AMD18_RS06960	COG1366	Belongs to the anti-sigma-factor antagonist family
AMD18_RS06965	COG2172	sigma factor antagonist activity
AMD18_RS06990	COG4771	TonB-dependent receptor
AMD18_RS07000	COG5507	3-demethylubiquinone-9 3-methyltransferase
AMD18_RS07005	COG2205	protein histidine kinase activity
AMD18_RS07020	COG3850	Histidine kinase
AMD18_RS07020	COG4999	Histidine kinase
AMD18_RS07020	COG2205	protein histidine kinase activity
AMD18_RS07020	COG3437	response regulator, receiver
AMD18_RS07025	COG0784	Response regulator, receiver
AMD18_RS07025	COG4191	Histidine kinase
AMD18_RS07055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMD18_RS07060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMD18_RS07070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMD18_RS07075	COG0228	four-way junction DNA binding
AMD18_RS07080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AMD18_RS07085	COG0336	Belongs to the RNA methyltransferase TrmD family
AMD18_RS07090	COG0335	large ribosomal subunit rRNA binding
AMD18_RS07120	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMD18_RS07130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AMD18_RS07140	COG3209	COG3209 Rhs family protein
AMD18_RS07160	COG3250	beta-galactosidase activity
AMD18_RS07165	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AMD18_RS07185	COG1960	acyl-CoA dehydrogenase activity
AMD18_RS07190	COG1024	Enoyl-CoA hydratase
AMD18_RS07210	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD18_RS07210	COG1024	Enoyl-CoA hydratase
AMD18_RS07225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD18_RS07230	COG0481	GTPase activity
AMD18_RS07245	COG0571	ribonuclease III activity
AMD18_RS07250	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMD18_RS07255	COG1381	Involved in DNA repair and RecF pathway recombination
AMD18_RS07265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMD18_RS07270	COG2954	triphosphatase activity
AMD18_RS07275	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMD18_RS07280	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AMD18_RS07285	COG3046	protein related to deoxyribodipyrimidine photolyase
AMD18_RS07290	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD18_RS07295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AMD18_RS07300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AMD18_RS07305	COG1278	Cold shock
AMD18_RS07310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD18_RS07320	COG1201	RNA secondary structure unwinding
AMD18_RS07325	COG1793	dna ligase
AMD18_RS07335	COG1793	dna ligase
AMD18_RS07335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AMD18_RS07365	COG0183	Belongs to the thiolase family
AMD18_RS07385	COG1451	nucleotide metabolic process
AMD18_RS07390	COG5487	UPF0391 membrane protein
AMD18_RS07400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AMD18_RS07420	COG1077	Cell shape determining protein MreB Mrl
AMD18_RS07425	COG1047	Peptidyl-prolyl cis-trans
AMD18_RS07435	COG2824	Alkylphosphonate utilization operon protein PhnA
AMD18_RS07440	COG1902	pentaerythritol trinitrate reductase activity
AMD18_RS07445	COG2814	Major facilitator Superfamily
AMD18_RS07480	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMD18_RS07480	COG0392	lysyltransferase activity
AMD18_RS07490	COG0251	oxidation-reduction process
AMD18_RS07495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMD18_RS07510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMD18_RS07535	COG1595	DNA-templated transcription, initiation
AMD18_RS07555	COG2878	Part of a membrane complex involved in electron transport
AMD18_RS07565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD18_RS07565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD18_RS07580	COG1131	(ABC) transporter
AMD18_RS07585	COG0346	lactoylglutathione lyase activity
AMD18_RS07590	COG0833	amino acid
AMD18_RS07595	COG2040	homocysteine
AMD18_RS07605	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AMD18_RS07625	COG1695	Transcriptional regulator
AMD18_RS07645	COG1981	membrane
AMD18_RS07660	COG0825	malonyl-CoA metabolic process
AMD18_RS07670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMD18_RS07675	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD18_RS07680	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD18_RS07685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD18_RS07690	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD18_RS07705	COG0750	zinc metalloprotease
AMD18_RS07710	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMD18_RS07715	COG0575	Belongs to the CDS family
AMD18_RS07720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMD18_RS07725	COG0233	cytoplasmic translational termination
AMD18_RS07730	COG0528	UMP kinase activity
AMD18_RS07740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMD18_RS07745	COG0052	Belongs to the universal ribosomal protein uS2 family
AMD18_RS07785	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AMD18_RS07795	COG1393	Belongs to the ArsC family
AMD18_RS07800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMD18_RS07805	COG0367	asparagine synthase
AMD18_RS07815	COG4774	siderophore transport
AMD18_RS07835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMD18_RS07865	COG1566	PFAM secretion protein HlyD family protein
AMD18_RS07870	COG2814	Major facilitator Superfamily
AMD18_RS07920	COG0339	signal peptide processing
AMD18_RS07925	COG0386	Belongs to the glutathione peroxidase family
AMD18_RS07980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AMD18_RS08000	COG1960	acyl-CoA dehydrogenase activity
AMD18_RS08020	COG0367	asparagine synthase
AMD18_RS08030	COG0305	Participates in initiation and elongation during chromosome replication
AMD18_RS08035	COG0415	Belongs to the DNA photolyase family
AMD18_RS08045	COG0583	DNA-binding transcription factor activity
AMD18_RS08090	COG3706	GGDEF domain
AMD18_RS08195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMD18_RS08210	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD18_RS08220	COG0497	DNA recombination
AMD18_RS08225	COG1420	regulation of RNA biosynthetic process
AMD18_RS08230	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMD18_RS08235	COG0443	Heat shock 70 kDa protein
AMD18_RS08240	COG0484	heat shock protein binding
AMD18_RS08245	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AMD18_RS08275	COG0583	DNA-binding transcription factor activity
AMD18_RS08280	COG1132	(ABC) transporter
AMD18_RS08315	COG2850	peptidyl-arginine hydroxylation
AMD18_RS08335	COG1253	flavin adenine dinucleotide binding
AMD18_RS08365	COG1131	(ABC) transporter
AMD18_RS08370	COG1725	Transcriptional regulator
AMD18_RS08375	COG0386	Belongs to the glutathione peroxidase family
AMD18_RS08390	COG2900	Belongs to the SlyX family
AMD18_RS08415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD18_RS08425	COG1410	methionine synthase
AMD18_RS08425	COG0646	methionine synthase
AMD18_RS08430	COG1410	methionine synthase
AMD18_RS08430	COG0646	methionine synthase
AMD18_RS08435	COG2226	methyltransferase
AMD18_RS08440	COG1960	acyl-CoA dehydrogenase activity
AMD18_RS08455	COG0557	exoribonuclease II activity
AMD18_RS08465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD18_RS08475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD18_RS08485	COG0704	Plays a role in the regulation of phosphate uptake
AMD18_RS08490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMD18_RS08495	COG0581	inorganic phosphate transmembrane transporter activity
AMD18_RS08500	COG0573	inorganic phosphate transmembrane transporter activity
AMD18_RS08505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AMD18_RS08530	COG0659	secondary active sulfate transmembrane transporter activity
AMD18_RS08535	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMD18_RS08545	COG1024	Enoyl-CoA hydratase
AMD18_RS08555	COG0494	nUDIX hydrolase
AMD18_RS08590	COG0488	(ABC) transporter
AMD18_RS08595	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AMD18_RS08595	COG0116	Belongs to the methyltransferase superfamily
AMD18_RS08600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMD18_RS08625	COG2925	Exonuclease
AMD18_RS08630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD18_RS08635	COG3844	kynureninase activity
AMD18_RS08645	COG0662	Cupin 2, conserved barrel domain protein
AMD18_RS08650	COG0288	reversible hydration of carbon dioxide
AMD18_RS08710	COG2808	Putative FMN-binding domain
AMD18_RS08730	COG0017	Asparaginyl-tRNA synthetase
AMD18_RS08735	COG0316	Belongs to the HesB IscA family
AMD18_RS08740	COG0360	Binds together with S18 to 16S ribosomal RNA
AMD18_RS08745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMD18_RS08750	COG0359	binds to the 23S rRNA
AMD18_RS08760	COG3115	cell septum assembly
AMD18_RS08770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMD18_RS08775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMD18_RS08780	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AMD18_RS08790	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMD18_RS08800	COG4993	Dehydrogenase
AMD18_RS08810	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AMD18_RS08820	COG2986	histidine ammonia-lyase
AMD18_RS08825	COG1228	amidohydrolase
AMD18_RS08870	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AMD18_RS08875	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AMD18_RS08880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AMD18_RS08885	COG0077	Prephenate dehydratase
AMD18_RS08885	COG1605	Chorismate mutase
AMD18_RS08890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMD18_RS08905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMD18_RS08910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMD18_RS08915	COG0583	DNA-binding transcription factor activity
AMD18_RS08930	COG0840	transmembrane signaling receptor activity
AMD18_RS08965	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AMD18_RS08970	COG0784	Response regulator, receiver
AMD18_RS08970	COG4191	Histidine kinase
AMD18_RS08985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD18_RS08995	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AMD18_RS09005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMD18_RS09020	COG1595	DNA-templated transcription, initiation
AMD18_RS09075	COG2244	polysaccharide biosynthetic process
AMD18_RS09105	COG2264	protein methyltransferase activity
AMD18_RS09115	COG0438	transferase activity, transferring glycosyl groups
AMD18_RS09130	COG1136	(ABC) transporter
AMD18_RS09140	COG0477	Major facilitator Superfamily
AMD18_RS09145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD18_RS09160	COG1253	flavin adenine dinucleotide binding
AMD18_RS09170	COG0306	phosphate transporter
AMD18_RS09195	COG0504	CTP synthase activity
AMD18_RS09200	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AMD18_RS09210	COG0148	phosphopyruvate hydratase activity
AMD18_RS09215	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AMD18_RS09220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMD18_RS09225	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMD18_RS09230	COG0585	pseudouridine synthase activity
AMD18_RS09235	COG2840	Smr protein MutS2
AMD18_RS09240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AMD18_RS09245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMD18_RS09250	COG1238	metal cluster binding
AMD18_RS09265	COG1534	Rna-binding protein
AMD18_RS09270	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AMD18_RS09280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMD18_RS09285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMD18_RS09295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMD18_RS09300	COG1546	Belongs to the CinA family
AMD18_RS09310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMD18_RS09315	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMD18_RS09320	COG2137	regulation of response to DNA damage stimulus
AMD18_RS09325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMD18_RS09330	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AMD18_RS09345	COG1741	Belongs to the pirin family
AMD18_RS09355	COG0583	DNA-binding transcription factor activity
AMD18_RS09380	COG0351	phosphomethylpyrimidine kinase
AMD18_RS09380	COG0352	thiamine-phosphate diphosphorylase activity
AMD18_RS09395	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AMD18_RS09400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMD18_RS09415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMD18_RS09425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMD18_RS09430	COG3734	2-keto-3-deoxy-galactonokinase
AMD18_RS09440	COG4948	Mandelate Racemase Muconate Lactonizing
AMD18_RS09445	COG0800	Aldolase
AMD18_RS09485	COG1501	Belongs to the glycosyl hydrolase 31 family
AMD18_RS09495	COG1070	Carbohydrate kinase
AMD18_RS09500	COG2115	Belongs to the xylose isomerase family
AMD18_RS09505	COG0477	Major facilitator Superfamily
AMD18_RS09515	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMD18_RS09520	COG1469	GTP cyclohydrolase I activity
AMD18_RS09540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMD18_RS09545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AMD18_RS09550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AMD18_RS09555	COG0166	Belongs to the GPI family
AMD18_RS09575	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD18_RS09585	COG2203	Gaf domain
AMD18_RS09585	COG3706	GGDEF domain
AMD18_RS09585	COG4251	negative regulation of phosphorylation
AMD18_RS09585	COG5001	Diguanylate cyclase
AMD18_RS09590	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD18_RS09595	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AMD18_RS09605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AMD18_RS09610	COG0671	phosphoesterase, PA-phosphatase related
AMD18_RS09620	COG1794	racemase activity, acting on amino acids and derivatives
AMD18_RS09625	COG0697	spore germination
AMD18_RS09630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMD18_RS09635	COG0167	dihydroorotate dehydrogenase activity
AMD18_RS09650	COG1012	belongs to the aldehyde dehydrogenase family
AMD18_RS09665	COG1215	transferase activity, transferring glycosyl groups
AMD18_RS09670	COG1649	PFAM Uncharacterised BCR, COG1649
AMD18_RS09670	COG0726	polysaccharide deacetylase
AMD18_RS09685	COG3210	domain, Protein
AMD18_RS09690	COG3210	domain, Protein
AMD18_RS09730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD18_RS09735	COG0124	histidyl-tRNA synthetase
AMD18_RS09745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMD18_RS09750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMD18_RS09755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMD18_RS09760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AMD18_RS09760	COG0131	Imidazoleglycerol-phosphate dehydratase
AMD18_RS09765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMD18_RS09770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AMD18_RS09775	COG0107	imidazoleglycerol-phosphate synthase activity
AMD18_RS09780	COG0140	phosphoribosyl-ATP diphosphatase activity
AMD18_RS09780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMD18_RS09795	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AMD18_RS09800	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AMD18_RS09805	COG0235	Class ii aldolase
AMD18_RS09810	COG0531	amino acid
AMD18_RS09815	COG0531	amino acid
AMD18_RS09825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMD18_RS09830	COG0277	FAD linked oxidase domain protein
AMD18_RS09850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMD18_RS09895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMD18_RS09900	COG2258	MOSC domain
AMD18_RS09905	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMD18_RS09910	COG0505	Belongs to the CarA family
AMD18_RS09920	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AMD18_RS09925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD18_RS09935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMD18_RS09980	COG3279	Response regulator of the LytR AlgR family
AMD18_RS09985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMD18_RS09990	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMD18_RS10000	COG2205	protein histidine kinase activity
AMD18_RS10000	COG2198	Histidine kinase
AMD18_RS10000	COG0784	Response regulator, receiver
AMD18_RS10005	COG1024	Enoyl-CoA hydratase
AMD18_RS10010	COG0318	PFAM AMP-dependent synthetase and ligase
AMD18_RS10040	COG2267	carboxylic ester hydrolase activity
AMD18_RS10050	COG2201	protein-glutamate methylesterase activity
AMD18_RS10055	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AMD18_RS10065	COG0840	transmembrane signaling receptor activity
AMD18_RS10070	COG0840	transmembrane signaling receptor activity
AMD18_RS10075	COG0840	transmembrane signaling receptor activity
AMD18_RS10085	COG0840	transmembrane signaling receptor activity
AMD18_RS10090	COG0840	transmembrane signaling receptor activity
AMD18_RS10095	COG0840	transmembrane signaling receptor activity
AMD18_RS10100	COG0840	transmembrane signaling receptor activity
AMD18_RS10115	COG0840	transmembrane signaling receptor activity
AMD18_RS10130	COG0840	transmembrane signaling receptor activity
AMD18_RS10135	COG2198	Histidine kinase
AMD18_RS10135	COG0643	Histidine kinase
AMD18_RS10140	COG0745	RESPONSE REGULATOR receiver
AMD18_RS10150	COG0835	chemotaxis
AMD18_RS10160	COG1360	Flagellar Motor Protein
AMD18_RS10165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AMD18_RS10250	COG0641	radical SAM
AMD18_RS10265	COG2198	Histidine kinase
AMD18_RS10265	COG0643	Histidine kinase
AMD18_RS10265	COG0784	Response regulator, receiver
AMD18_RS10295	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AMD18_RS10325	COG1684	flagellar biosynthetic protein fliR
AMD18_RS10340	COG3190	flagellar
AMD18_RS10390	COG1677	Flagellar hook-basal body complex protein FliE
AMD18_RS10420	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS10430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD18_RS10450	COG2201	protein-glutamate methylesterase activity
AMD18_RS10480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AMD18_RS10485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AMD18_RS10490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AMD18_RS10500	COG3951	Flagellar rod assembly protein muramidase FlgJ
AMD18_RS10500	COG1705	Flagellar rod assembly protein muramidase FlgJ
AMD18_RS10505	COG1706	bacterial-type flagellum-dependent cell motility
AMD18_RS10510	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AMD18_RS10520	COG4787	bacterial-type flagellum-dependent cell motility
AMD18_RS10530	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AMD18_RS10535	COG1558	bacterial-type flagellum-dependent cell motility
AMD18_RS10545	COG0835	chemotaxis
AMD18_RS10545	COG0784	Response regulator, receiver
AMD18_RS10565	COG5002	protein histidine kinase activity
AMD18_RS10595	COG2915	High frequency lysogenization protein hflD homolog
AMD18_RS10600	COG0482	sulfurtransferase activity
AMD18_RS10615	COG0542	response to heat
AMD18_RS10625	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AMD18_RS10635	COG0492	ferredoxin-NADP+ reductase activity
AMD18_RS10640	COG1674	ftsk spoiiie
AMD18_RS10650	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AMD18_RS10660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AMD18_RS10665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMD18_RS10675	COG0183	Belongs to the thiolase family
AMD18_RS10680	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD18_RS10680	COG1024	Enoyl-CoA hydratase
AMD18_RS10695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMD18_RS10705	COG1426	Protein conserved in bacteria
AMD18_RS10715	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD18_RS10720	COG1160	GTP binding
AMD18_RS10725	COG0303	'Molybdopterin
AMD18_RS10730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMD18_RS10765	COG0708	Exodeoxyribonuclease III
AMD18_RS10775	COG0303	'Molybdopterin
AMD18_RS10780	COG0746	molybdenum cofactor guanylyltransferase activity
AMD18_RS10795	COG1914	H( )-stimulated, divalent metal cation uptake system
AMD18_RS10810	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AMD18_RS10815	COG0668	transmembrane transport
AMD18_RS10825	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AMD18_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS10845	COG1183	phosphatidylcholine synthase activity
AMD18_RS10855	COG3243	poly(R)-hydroxyalkanoic acid synthase
AMD18_RS10870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD18_RS10870	COG0723	plastoquinol--plastocyanin reductase activity
AMD18_RS10880	COG2183	response to ionizing radiation
AMD18_RS10885	COG2205	protein histidine kinase activity
AMD18_RS10885	COG0784	Response regulator, receiver
AMD18_RS10950	COG0800	Aldolase
AMD18_RS10955	COG0129	dihydroxy-acid dehydratase activity
AMD18_RS10960	COG0363	glucosamine-6-phosphate deaminase activity
AMD18_RS10965	COG0837	glucose binding
AMD18_RS10970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AMD18_RS10990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AMD18_RS11005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMD18_RS11010	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AMD18_RS11020	COG4591	ABC-type transport system involved in lipoprotein release permease component
AMD18_RS11025	COG1136	(ABC) transporter
AMD18_RS11040	COG0811	peptide transport
AMD18_RS11050	COG1132	(ABC) transporter
AMD18_RS11055	COG1663	tetraacyldisaccharide 4'-kinase activity
AMD18_RS11060	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AMD18_RS11065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMD18_RS11075	COG0322	excinuclease ABC activity
AMD18_RS11080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD18_RS11100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD18_RS11105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD18_RS11135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AMD18_RS11155	COG1054	Belongs to the UPF0176 family
AMD18_RS11165	COG1530	ribonuclease E activity
AMD18_RS11175	COG3064	Membrane
AMD18_RS11180	COG0428	transporter
AMD18_RS11190	COG2154	pterin-4-alpha-carbinolamine dehydratase
AMD18_RS11195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AMD18_RS11195	COG0316	Belongs to the HesB IscA family
AMD18_RS11240	COG2226	methyltransferase
AMD18_RS11240	COG1073	alpha beta
AMD18_RS11250	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS11285	COG1238	metal cluster binding
AMD18_RS11320	COG3279	Response regulator of the LytR AlgR family
AMD18_RS11365	COG4566	intracellular signal transduction
AMD18_RS11375	COG5001	Diguanylate cyclase
AMD18_RS11390	COG3685	Protein conserved in bacteria
AMD18_RS11405	COG1648	precorrin-2 dehydrogenase activity
AMD18_RS11405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMD18_RS11420	COG2814	Major facilitator Superfamily
AMD18_RS11440	COG1335	isochorismatase
AMD18_RS11455	COG2197	response regulator
AMD18_RS11475	COG0583	DNA-binding transcription factor activity
AMD18_RS11480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMD18_RS11485	COG3002	Belongs to the UPF0753 family
AMD18_RS11500	COG1396	sequence-specific DNA binding
AMD18_RS11505	COG5489	Protein of unknown function (DUF736)
AMD18_RS11510	COG2003	Belongs to the UPF0758 family
AMD18_RS11535	COG0582	viral genome integration into host DNA
AMD18_RS11550	COG4774	siderophore transport
AMD18_RS11565	COG2336	PFAM SpoVT AbrB
AMD18_RS11590	COG4206	TonB-dependent receptor
AMD18_RS11630	COG2274	protein secretion by the type I secretion system
AMD18_RS11680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMD18_RS11685	COG0270	DNA (cytosine-5-)-methyltransferase activity
AMD18_RS11735	COG4804	nuclease activity
AMD18_RS11755	COG5006	permease, DMT superfamily
AMD18_RS11770	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMD18_RS11780	COG3938	Belongs to the proline racemase family
AMD18_RS11795	COG2807	transmembrane transport
AMD18_RS11800	COG2207	Transcriptional regulator
AMD18_RS11950	COG0210	DNA helicase
AMD18_RS12030	COG2084	Dehydrogenase
AMD18_RS12050	COG2003	Belongs to the UPF0758 family
AMD18_RS12085	COG0582	viral genome integration into host DNA
AMD18_RS12090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD18_RS12090	COG0519	Catalyzes the synthesis of GMP from XMP
AMD18_RS12100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMD18_RS12110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMD18_RS12110	COG0475	glutathione-regulated potassium exporter activity
AMD18_RS12115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMD18_RS12125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMD18_RS12130	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AMD18_RS12140	COG0776	regulation of translation
AMD18_RS12145	COG0539	negative regulation of cytoplasmic translation
AMD18_RS12150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AMD18_RS12165	COG2957	Belongs to the agmatine deiminase family
AMD18_RS12170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD18_RS12195	COG0395	ABC-type sugar transport system, permease component
AMD18_RS12200	COG1175	transmembrane transport
AMD18_RS12230	COG2350	Protein conserved in bacteria
AMD18_RS12235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AMD18_RS12240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMD18_RS12245	COG1187	pseudouridine synthase activity
AMD18_RS12265	COG0436	Aminotransferase
AMD18_RS12270	COG4133	protoheme IX ABC transporter activity
AMD18_RS12290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AMD18_RS12295	COG1138	Cytochrome C-type biogenesis protein
AMD18_RS12315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD18_RS12320	COG1278	Cold shock
AMD18_RS12325	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AMD18_RS12330	COG4988	ABC transporter
AMD18_RS12340	COG1294	oxidase, subunit
AMD18_RS12365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AMD18_RS12370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AMD18_RS12380	COG0165	Argininosuccinate lyase
AMD18_RS12385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AMD18_RS12395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMD18_RS12400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMD18_RS12410	COG0137	argininosuccinate synthase activity
AMD18_RS12415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMD18_RS12425	COG0215	cysteine-tRNA ligase activity
AMD18_RS12430	COG2166	iron-sulfur cluster assembly
AMD18_RS12450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AMD18_RS12455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMD18_RS12480	COG4302	ethanolamine ammonia-lyase activity
AMD18_RS12510	COG2963	transposase activity
AMD18_RS12530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMD18_RS12535	COG0402	S-adenosylhomocysteine deaminase activity
AMD18_RS12545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMD18_RS12550	COG1509	lysine 2,3-aminomutase activity
AMD18_RS12555	COG3300	MHYT domain
AMD18_RS12555	COG5001	Diguanylate cyclase
AMD18_RS12570	COG0483	inositol monophosphate 1-phosphatase activity
AMD18_RS12575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AMD18_RS12590	COG0488	(ABC) transporter
AMD18_RS12595	COG0513	Belongs to the DEAD box helicase family
AMD18_RS12600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMD18_RS12605	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AMD18_RS12615	COG0625	glutathione transferase activity
AMD18_RS12625	COG4681	YaeQ
AMD18_RS12630	COG2081	HI0933 family
AMD18_RS12640	COG0501	Belongs to the peptidase M48B family
AMD18_RS12645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD18_RS12650	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS12670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AMD18_RS12675	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMD18_RS12680	COG0802	atpase or kinase
AMD18_RS12685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AMD18_RS12685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMD18_RS12690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMD18_RS12695	COG1570	exodeoxyribonuclease VII activity
AMD18_RS12705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMD18_RS12885	COG0835	chemotaxis
AMD18_RS12890	COG0840	transmembrane signaling receptor activity
AMD18_RS12895	COG2094	Belongs to the DNA glycosylase MPG family
AMD18_RS12900	COG1201	RNA secondary structure unwinding
AMD18_RS12915	COG2969	positive regulation of protein catabolic process
AMD18_RS12920	COG0625	glutathione transferase activity
AMD18_RS12925	COG2857	Cytochrome c1
AMD18_RS12930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AMD18_RS12935	COG0723	plastoquinol--plastocyanin reductase activity
AMD18_RS12940	COG0741	lytic transglycosylase activity
AMD18_RS12955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMD18_RS12960	COG1702	phosphate starvation-inducible protein PhoH
AMD18_RS12970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMD18_RS12980	COG4535	Mg2 and Co2 transporter CorC
AMD18_RS12995	COG1012	belongs to the aldehyde dehydrogenase family
AMD18_RS13005	COG1177	transmembrane transport
AMD18_RS13010	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMD18_RS13015	COG3842	ATPase activity
AMD18_RS13035	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AMD18_RS13050	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMD18_RS13055	COG0174	glutamine synthetase
AMD18_RS13060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD18_RS13070	COG2703	oxygen carrier activity
AMD18_RS13075	COG0477	Major facilitator Superfamily
AMD18_RS13085	COG0243	molybdopterin cofactor binding
AMD18_RS13090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMD18_RS13095	COG2223	nitrite transmembrane transporter activity
AMD18_RS13100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMD18_RS13110	COG2733	membrane
AMD18_RS13115	COG5002	protein histidine kinase activity
AMD18_RS13115	COG0784	Response regulator, receiver
AMD18_RS13115	COG2205	protein histidine kinase activity
AMD18_RS13125	COG0477	Major facilitator Superfamily
AMD18_RS13130	COG2902	Dehydrogenase
AMD18_RS13140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD18_RS13145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD18_RS13150	COG1609	Transcriptional regulator
AMD18_RS13155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMD18_RS13155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD18_RS13160	COG1105	Belongs to the carbohydrate kinase PfkB family
AMD18_RS13165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMD18_RS13165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMD18_RS13200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMD18_RS13210	COG1862	Preprotein translocase
AMD18_RS13215	COG0343	queuine tRNA-ribosyltransferase activity
AMD18_RS13220	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMD18_RS13260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AMD18_RS13265	COG3291	Pkd domain containing protein
AMD18_RS13275	COG0405	Gamma-glutamyltransferase
AMD18_RS13280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMD18_RS13295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMD18_RS13300	COG0742	ribosomal rna small subunit methyltransferase
AMD18_RS13305	COG0326	Molecular chaperone. Has ATPase activity
AMD18_RS13370	COG0531	amino acid
AMD18_RS13385	COG0006	proline dipeptidase activity
AMD18_RS13395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMD18_RS13410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD18_RS13415	COG3938	Belongs to the proline racemase family
AMD18_RS13425	COG0552	protein localization to endoplasmic reticulum
AMD18_RS13430	COG1194	a g-specific adenine glycosylase
AMD18_RS13435	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AMD18_RS13440	COG0784	Response regulator, receiver
AMD18_RS13440	COG4191	Histidine kinase
AMD18_RS13455	COG0322	excinuclease ABC activity
AMD18_RS13470	COG3040	lipid binding
AMD18_RS13480	COG1960	acyl-CoA dehydrogenase activity
AMD18_RS13490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AMD18_RS13510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD18_RS13515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD18_RS13520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD18_RS13545	COG0438	transferase activity, transferring glycosyl groups
AMD18_RS13555	COG0438	transferase activity, transferring glycosyl groups
AMD18_RS13560	COG0438	transferase activity, transferring glycosyl groups
AMD18_RS13610	COG0072	phenylalanine-tRNA ligase activity
AMD18_RS13610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD18_RS13615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMD18_RS13630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AMD18_RS13635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMD18_RS13660	COG1082	Xylose isomerase domain protein TIM barrel
AMD18_RS13675	COG0366	Alpha amylase catalytic
AMD18_RS13725	COG3702	type iv secretory pathway
AMD18_RS13745	COG2948	multi-organism process
AMD18_RS13765	COG3505	Type IV secretory pathway VirD4
AMD18_RS13780	COG0556	nucleotide-excision repair
AMD18_RS13850	COG4695	Portal protein
AMD18_RS13895	COG3179	chitinase
AMD18_RS13990	COG3275	phosphorelay sensor kinase activity
AMD18_RS13995	COG1611	Belongs to the LOG family
AMD18_RS14005	COG2095	MarC family integral membrane protein
AMD18_RS14015	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AMD18_RS14050	COG1185	polyribonucleotide nucleotidyltransferase activity
AMD18_RS14055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMD18_RS14060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMD18_RS14065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AMD18_RS14070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AMD18_RS14075	COG0195	Participates in both transcription termination and antitermination
AMD18_RS14080	COG0779	Required for maturation of 30S ribosomal subunits
AMD18_RS14090	COG1007	ATP synthesis coupled electron transport
AMD18_RS14115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD18_RS14120	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AMD18_RS14130	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AMD18_RS14135	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AMD18_RS14140	COG0649	NAD binding
AMD18_RS14145	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD18_RS14150	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD18_RS14155	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD18_RS14170	COG0149	triose-phosphate isomerase activity
AMD18_RS14175	COG0300	oxidoreductase activity
AMD18_RS14210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD18_RS14215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AMD18_RS14220	COG0159	tryptophan synthase activity
AMD18_RS14230	COG0133	tryptophan synthase activity
AMD18_RS14240	COG0135	phosphoribosylanthranilate isomerase activity
AMD18_RS14245	COG0101	tRNA pseudouridine synthase activity
AMD18_RS14265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AMD18_RS14270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMD18_RS14275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AMD18_RS14280	COG2890	protein-(glutamine-N5) methyltransferase activity
AMD18_RS14290	COG0688	phosphatidylethanolamine metabolic process
AMD18_RS14300	COG0433	COG0433 Predicted ATPase
AMD18_RS14305	COG0494	nUDIX hydrolase
AMD18_RS14320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD18_RS14325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMD18_RS14350	COG0717	Belongs to the dCTP deaminase family
AMD18_RS14355	COG0489	protein tyrosine kinase activity
AMD18_RS14375	COG3590	peptidase
AMD18_RS14380	COG3590	peptidase
AMD18_RS14400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMD18_RS14405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD18_RS14410	COG2311	Membrane
AMD18_RS14415	COG1047	Peptidyl-prolyl cis-trans
AMD18_RS14420	COG0791	NLP P60 protein
AMD18_RS14425	COG0791	NLP P60 protein
AMD18_RS14435	COG4106	trans-aconitate 2-methyltransferase activity
AMD18_RS14440	COG1301	dicarboxylic acid transport
AMD18_RS14445	COG1785	Belongs to the alkaline phosphatase family
AMD18_RS14450	COG0037	tRNA processing
AMD18_RS14455	COG1722	exodeoxyribonuclease VII activity
AMD18_RS14460	COG0142	geranyltranstransferase activity
AMD18_RS14465	COG4104	PAAR repeat-containing protein
AMD18_RS14475	COG0312	modulator of DNA gyrase
AMD18_RS14480	COG3028	Belongs to the UPF0307 family
AMD18_RS14485	COG0312	modulator of DNA gyrase
AMD18_RS14495	COG3164	Protein of unknown function
AMD18_RS14505	COG0424	maF-like protein
AMD18_RS14510	COG2968	Membrane
AMD18_RS14525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AMD18_RS14540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMD18_RS14555	COG0495	leucyl-tRNA aminoacylation
AMD18_RS14565	COG3118	belongs to the thioredoxin family
AMD18_RS14590	COG2155	Conserved Protein
AMD18_RS14635	COG1132	(ABC) transporter
AMD18_RS14660	COG1538	Outer membrane efflux protein
AMD18_RS14665	COG0745	RESPONSE REGULATOR receiver
AMD18_RS14670	COG5000	phosphorelay sensor kinase activity
AMD18_RS14670	COG5002	protein histidine kinase activity
AMD18_RS14675	COG0475	glutathione-regulated potassium exporter activity
AMD18_RS14685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMD18_RS14710	COG1187	pseudouridine synthase activity
AMD18_RS14715	COG5002	protein histidine kinase activity
AMD18_RS14715	COG5001	Diguanylate cyclase
AMD18_RS14830	COG0667	Aldo Keto reductase
AMD18_RS14835	COG2814	Major facilitator Superfamily
AMD18_RS14840	COG0583	DNA-binding transcription factor activity
AMD18_RS14850	COG2207	Transcriptional regulator
AMD18_RS14860	COG1309	transcriptional regulator
AMD18_RS14885	COG0735	belongs to the Fur family
AMD18_RS14890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD18_RS14915	COG4452	Inner membrane protein CreD
AMD18_RS14925	COG2205	protein histidine kinase activity
AMD18_RS14930	COG0745	RESPONSE REGULATOR receiver
AMD18_RS14935	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AMD18_RS14945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AMD18_RS14980	COG0643	Histidine kinase
AMD18_RS14980	COG2198	Histidine kinase
AMD18_RS14985	COG0840	transmembrane signaling receptor activity
AMD18_RS14990	COG0835	chemotaxis
AMD18_RS14995	COG2199	diguanylate cyclase activity
AMD18_RS14995	COG2200	EAL domain
AMD18_RS14995	COG2202	Pas domain
AMD18_RS15000	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AMD18_RS15005	COG2201	protein-glutamate methylesterase activity
AMD18_RS15010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD18_RS15015	COG3590	peptidase
AMD18_RS15025	COG0588	phosphoglycerate mutase activity
AMD18_RS15030	COG1515	deoxyribonuclease V activity
AMD18_RS15040	COG1741	Belongs to the pirin family
AMD18_RS15055	COG1741	Belongs to the pirin family
AMD18_RS15060	COG1966	Carbon starvation protein
AMD18_RS15065	COG2879	small protein
AMD18_RS15120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMD18_RS15125	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMD18_RS15130	COG2080	2 iron, 2 sulfur cluster binding
AMD18_RS15140	COG2203	Gaf domain
AMD18_RS15140	COG4251	negative regulation of phosphorylation
AMD18_RS15140	COG3706	GGDEF domain
AMD18_RS15140	COG5001	Diguanylate cyclase
AMD18_RS15145	COG0629	single-stranded DNA binding
AMD18_RS15150	COG0142	geranyltranstransferase activity
AMD18_RS15160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMD18_RS15175	COG0527	aspartate kinase activity
AMD18_RS15180	COG0384	phenazine biosynthesis protein PhzF
AMD18_RS15185	COG0384	phenazine biosynthesis protein PhzF
AMD18_RS15195	COG1764	response to oxidative stress
AMD18_RS15200	COG0540	Belongs to the ATCase OTCase family
AMD18_RS15205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AMD18_RS15210	COG1678	Uncharacterized ACR, COG1678
AMD18_RS15220	COG0519	Catalyzes the synthesis of GMP from XMP
AMD18_RS15230	COG5297	Belongs to the glycosyl hydrolase family 6
AMD18_RS15245	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AMD18_RS15260	COG0739	heme binding
AMD18_RS15280	COG0693	protein deglycase activity
AMD18_RS15290	COG1959	2 iron, 2 sulfur cluster binding
AMD18_RS15295	COG0719	Fe-S assembly protein
AMD18_RS15300	COG0396	ATPase activity
AMD18_RS15305	COG0719	Fe-S assembly protein
AMD18_RS15310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMD18_RS15320	COG2146	nitrite reductase [NAD(P)H] activity
AMD18_RS15325	COG4774	siderophore transport
AMD18_RS15330	COG3128	pkhd-type hydroxylase
AMD18_RS15355	COG1477	protein flavinylation
AMD18_RS15360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AMD18_RS15375	COG1555	photosystem II stabilization
AMD18_RS15380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMD18_RS15390	COG3178	'Phosphotransferase
AMD18_RS15395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMD18_RS15405	COG0628	permease
AMD18_RS15415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMD18_RS15425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AMD18_RS15445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMD18_RS15450	COG0271	Belongs to the BolA IbaG family
AMD18_RS15460	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AMD18_RS15470	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AMD18_RS15475	COG1137	ATPase activity
AMD18_RS15490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD18_RS15495	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AMD18_RS15500	COG1660	Displays ATPase and GTPase activities
AMD18_RS15510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD18_RS15515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMD18_RS15520	COG2239	Acts as a magnesium transporter
AMD18_RS15530	COG1294	oxidase, subunit
AMD18_RS15535	COG1271	oxidase subunit
AMD18_RS15545	COG1113	amino acid transport
AMD18_RS15565	COG2197	response regulator
AMD18_RS15570	COG0531	amino acid
AMD18_RS15590	COG1234	tRNA 3'-trailer cleavage
AMD18_RS15625	COG2814	Major facilitator Superfamily
AMD18_RS15635	COG0754	glutathionylspermidine amidase activity
AMD18_RS15660	COG1842	Phage shock protein A
AMD18_RS15670	COG0259	pyridoxamine-phosphate oxidase activity
AMD18_RS15675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMD18_RS15680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AMD18_RS15690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AMD18_RS15765	COG2814	Major facilitator Superfamily
AMD18_RS15785	COG2198	Histidine kinase
AMD18_RS15785	COG2205	protein histidine kinase activity
AMD18_RS15785	COG0784	Response regulator, receiver
AMD18_RS15790	COG2353	YceI-like domain
AMD18_RS15810	COG1760	l-serine dehydratase
AMD18_RS15820	COG0527	aspartate kinase activity
AMD18_RS15820	COG0460	homoserine dehydrogenase
AMD18_RS15825	COG0626	cystathionine gamma-synthase activity
AMD18_RS15830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD18_RS15835	COG0739	heme binding
AMD18_RS15840	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AMD18_RS15845	COG1272	protein, Hemolysin III
AMD18_RS15850	COG2982	Protein involved in outer membrane biogenesis
AMD18_RS15855	COG0517	IMP dehydrogenase activity
AMD18_RS15855	COG0516	GMP reductase activity
AMD18_RS15860	COG0463	Glycosyl transferase, family 2
AMD18_RS15865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMD18_RS15870	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AMD18_RS15880	COG4771	TonB-dependent receptor
AMD18_RS15890	COG1309	transcriptional regulator
AMD18_RS15900	COG1960	acyl-CoA dehydrogenase activity
AMD18_RS15925	COG0509	glycine decarboxylation via glycine cleavage system
AMD18_RS15930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMD18_RS15940	COG0330	HflC and HflK could
AMD18_RS15945	COG1742	UPF0060 membrane protein
AMD18_RS15950	COG3956	TIGRFAM MazG family protein
AMD18_RS15960	COG0494	nUDIX hydrolase
AMD18_RS15970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AMD18_RS15975	COG0837	glucose binding
AMD18_RS15990	COG3858	chitin binding
AMD18_RS15990	COG1388	LysM domain
AMD18_RS16005	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD18_RS16020	COG0531	amino acid
AMD18_RS16030	COG1486	melibiose metabolic process
AMD18_RS16040	COG3537	Alpha-1,2-mannosidase
AMD18_RS16075	COG3142	Participates in the control of copper homeostasis
AMD18_RS16080	COG1446	asparaginase
AMD18_RS16105	COG2198	Histidine kinase
AMD18_RS16105	COG0643	Histidine kinase
AMD18_RS16105	COG0784	Response regulator, receiver
AMD18_RS16110	COG0840	transmembrane signaling receptor activity
AMD18_RS16115	COG0835	chemotaxis
AMD18_RS16130	COG0189	ligase activity
AMD18_RS16140	COG1397	ADP-ribosylglycohydrolase
AMD18_RS16150	COG1199	ATP-dependent helicase activity
AMD18_RS16160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMD18_RS16165	COG1215	transferase activity, transferring glycosyl groups
AMD18_RS16175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD18_RS16180	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMD18_RS16185	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AMD18_RS16190	COG0535	radical SAM domain protein
AMD18_RS16195	COG0535	radical SAM domain protein
AMD18_RS16210	COG0837	glucose binding
AMD18_RS16220	COG1643	Atp-dependent helicase
AMD18_RS16225	COG0783	Belongs to the Dps family
AMD18_RS16230	COG0514	ATP-dependent DNA helicase (RecQ)
AMD18_RS16265	COG0840	transmembrane signaling receptor activity
AMD18_RS16285	COG3920	Histidine kinase
AMD18_RS16290	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AMD18_RS16300	COG0602	queuosine metabolic process
AMD18_RS16310	COG2885	chlorophyll binding
AMD18_RS16315	COG0823	Involved in the tonB-independent uptake of proteins
AMD18_RS16325	COG0848	biopolymer transport protein
AMD18_RS16335	COG0824	Thioesterase
AMD18_RS16340	COG2255	four-way junction helicase activity
AMD18_RS16350	COG3158	transport of potassium into the cell
AMD18_RS16355	COG0632	four-way junction helicase activity
AMD18_RS16360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMD18_RS16365	COG0217	transcriptional regulatory protein
AMD18_RS16380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMD18_RS16395	COG0477	Major facilitator Superfamily
AMD18_RS16430	COG0488	(ABC) transporter
AMD18_RS16465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMD18_RS16465	COG4651	solute:proton antiporter activity
AMD18_RS16490	COG4772	TonB-dependent receptor
AMD18_RS16500	COG4264	IucA IucC family
AMD18_RS16515	COG0019	diaminopimelate decarboxylase activity
AMD18_RS16540	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AMD18_RS16550	COG1492	cobalamin metabolic process
AMD18_RS16560	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMD18_RS16580	COG4206	TonB-dependent receptor
AMD18_RS16585	COG0542	response to heat
AMD18_RS16590	COG1116	anion transmembrane transporter activity
AMD18_RS16595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD18_RS16600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMD18_RS16605	COG0667	Aldo Keto reductase
AMD18_RS16610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD18_RS16615	COG4771	TonB-dependent receptor
AMD18_RS16620	COG2827	Endonuclease containing a URI domain
AMD18_RS16660	COG1877	trehalose-phosphatase activity
AMD18_RS16665	COG3387	PFAM Glycoside hydrolase 15-related
AMD18_RS16680	COG0840	transmembrane signaling receptor activity
AMD18_RS16685	COG3011	Protein conserved in bacteria
AMD18_RS16700	COG0564	pseudouridine synthase activity
AMD18_RS16705	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD18_RS16715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD18_RS16715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AMD18_RS16745	COG2951	lytic endotransglycosylase activity
AMD18_RS16750	COG4644	lycopene metabolic process
AMD18_RS16770	COG2369	cell adhesion
AMD18_RS16795	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AMD18_RS16800	COG0045	succinate-CoA ligase (ADP-forming) activity
AMD18_RS16815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD18_RS16845	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AMD18_RS16850	COG0237	dephospho-CoA kinase activity
AMD18_RS16875	COG5002	protein histidine kinase activity
AMD18_RS16880	COG0745	RESPONSE REGULATOR receiver
AMD18_RS16950	COG2003	Belongs to the UPF0758 family
AMD18_RS16975	COG0784	Response regulator, receiver
AMD18_RS16975	COG4191	Histidine kinase
AMD18_RS16980	COG4191	Histidine kinase
AMD18_RS16980	COG0784	Response regulator, receiver
AMD18_RS17090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMD18_RS17115	COG2022	thiamine diphosphate biosynthetic process
AMD18_RS17120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMD18_RS17125	COG3273	potassium ion transport
AMD18_RS17125	COG0471	metal ion transport
AMD18_RS17145	COG1970	mechanosensitive ion channel activity
AMD18_RS17170	COG3250	beta-galactosidase activity
AMD18_RS17175	COG4948	Mandelate Racemase Muconate Lactonizing
AMD18_RS17190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD18_RS17200	COG0308	aminopeptidase N
AMD18_RS17250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD18_RS17260	COG2895	sulfate adenylyltransferase (ATP) activity
AMD18_RS17260	COG0529	Catalyzes the synthesis of activated sulfate
AMD18_RS17265	COG0175	sulfate reduction
AMD18_RS17270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AMD18_RS17275	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMD18_RS17280	COG0175	sulfate reduction
AMD18_RS17300	COG0784	Response regulator, receiver
AMD18_RS17300	COG2205	protein histidine kinase activity
AMD18_RS17300	COG2198	Histidine kinase
AMD18_RS17320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMD18_RS17320	COG1648	precorrin-2 dehydrogenase activity
AMD18_RS17335	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AMD18_RS17340	COG3588	fructose-bisphosphate aldolase
AMD18_RS17345	COG0469	pyruvate kinase activity
AMD18_RS17355	COG0126	phosphoglycerate kinase activity
AMD18_RS17375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AMD18_RS17385	COG3047	cAMP biosynthetic process
AMD18_RS17390	COG3047	cAMP biosynthetic process
AMD18_RS17400	COG3453	Protein conserved in bacteria
AMD18_RS17400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD18_RS17405	COG0725	ABC transporter, periplasmic molybdate-binding protein
AMD18_RS17410	COG4149	molybdate abc transporter
AMD18_RS17415	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AMD18_RS17450	COG1376	ErfK ybiS ycfS ynhG family protein
AMD18_RS17455	COG0739	heme binding
AMD18_RS17465	COG4773	Receptor
AMD18_RS17485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AMD18_RS17490	COG1301	dicarboxylic acid transport
AMD18_RS17500	COG2304	oxidoreductase activity
AMD18_RS17520	COG0714	Associated with various cellular activities
AMD18_RS17550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AMD18_RS17575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AMD18_RS17585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD18_RS17595	COG0194	GDP metabolic process
AMD18_RS17600	COG1561	YicC-like family, N-terminal region
AMD18_RS17605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMD18_RS17615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMD18_RS17620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMD18_RS17635	COG0006	proline dipeptidase activity
AMD18_RS17645	COG0006	proline dipeptidase activity
AMD18_RS17650	COG3079	Belongs to the UPF0149 family
AMD18_RS17665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMD18_RS17675	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AMD18_RS17685	COG2912	Transglutaminase-like superfamily
AMD18_RS17690	COG1773	rubredoxin
AMD18_RS17695	COG0352	thiamine-phosphate diphosphorylase activity
AMD18_RS17710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMD18_RS17725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMD18_RS17755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMD18_RS17760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD18_RS17765	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS17775	COG0671	phosphoesterase, PA-phosphatase related
AMD18_RS17780	COG3781	membrane
AMD18_RS17790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMD18_RS17795	COG0563	adenylate kinase activity
AMD18_RS17810	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AMD18_RS17820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMD18_RS17840	COG3710	Transcriptional regulator
AMD18_RS17845	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMD18_RS17855	COG0840	transmembrane signaling receptor activity
AMD18_RS17860	COG0405	Gamma-glutamyltransferase
AMD18_RS17865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMD18_RS17885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMD18_RS17890	COG0473	3-isopropylmalate dehydrogenase activity
AMD18_RS17895	COG0066	3-isopropylmalate dehydratase activity
AMD18_RS17900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMD18_RS17920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMD18_RS17925	COG1538	Outer membrane efflux protein
AMD18_RS17930	COG1519	Transferase
AMD18_RS17935	COG1560	Kdo2-lipid A biosynthetic process
AMD18_RS17960	COG0280	phosphate acetyltransferase
AMD18_RS17960	COG0281	malic enzyme
AMD18_RS17965	COG1301	dicarboxylic acid transport
AMD18_RS17990	COG0583	DNA-binding transcription factor activity
AMD18_RS17995	COG0667	Aldo Keto reductase
AMD18_RS18010	COG2197	response regulator
AMD18_RS18020	COG0642	Histidine kinase
AMD18_RS18035	COG2851	Citrate transporter
AMD18_RS18040	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS18045	COG1609	Transcriptional regulator
AMD18_RS18050	COG2211	Major facilitator Superfamily
AMD18_RS18075	COG1162	GTPase activity
AMD18_RS18095	COG4773	Receptor
AMD18_RS18100	COG0726	polysaccharide deacetylase
AMD18_RS18105	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AMD18_RS18140	COG1307	EDD domain protein, DegV family
AMD18_RS18145	COG0242	peptide deformylase activity
AMD18_RS18165	COG0457	Tetratricopeptide repeat
AMD18_RS18170	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AMD18_RS18175	COG1215	transferase activity, transferring glycosyl groups
AMD18_RS18180	COG1215	transferase activity, transferring glycosyl groups
AMD18_RS18195	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AMD18_RS18250	COG2188	Transcriptional regulator
AMD18_RS18260	COG1450	Type ii and iii secretion system protein
AMD18_RS18275	COG3166	PFAM Fimbrial assembly family protein
AMD18_RS18280	COG3156	type II secretion system protein K
AMD18_RS18285	COG4795	General secretion pathway protein
AMD18_RS18290	COG2165	general secretion pathway protein
AMD18_RS18295	COG4970	Tfp pilus assembly protein FimT
AMD18_RS18300	COG2165	general secretion pathway protein
AMD18_RS18305	COG1459	type II secretion system
AMD18_RS18310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD18_RS18315	COG1404	Belongs to the peptidase S8 family
AMD18_RS18320	COG5295	Hep Hag repeat protein
AMD18_RS18325	COG1404	Belongs to the peptidase S8 family
AMD18_RS18330	COG5295	Hep Hag repeat protein
AMD18_RS18340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMD18_RS18340	COG0047	phosphoribosylformylglycinamidine synthase activity
AMD18_RS18345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMD18_RS18350	COG4974	Belongs to the 'phage' integrase family
AMD18_RS18365	COG0795	lipopolysaccharide-transporting ATPase activity
AMD18_RS18375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMD18_RS18390	COG0525	valine-tRNA ligase activity
AMD18_RS18420	COG1183	phosphatidylcholine synthase activity
AMD18_RS18430	COG0442	prolyl-tRNA aminoacylation
AMD18_RS18445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMD18_RS18450	COG1127	ABC transporter
AMD18_RS18455	COG3218	ABC-type transport auxiliary lipoprotein component
AMD18_RS18455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMD18_RS18490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD18_RS18495	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AMD18_RS18495	COG0662	Cupin 2, conserved barrel domain protein
AMD18_RS18525	COG2086	electron transfer activity
AMD18_RS18540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMD18_RS18540	COG0546	phosphoglycolate phosphatase activity
AMD18_RS18545	COG0277	FAD linked oxidase domain protein
AMD18_RS18560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD18_RS18590	COG1216	Glycosyl transferase, family 2
AMD18_RS18590	COG0438	transferase activity, transferring glycosyl groups
AMD18_RS18610	COG0626	cystathionine gamma-synthase activity
AMD18_RS18645	COG0625	glutathione transferase activity
AMD18_RS18655	COG0513	Belongs to the DEAD box helicase family
AMD18_RS18665	COG4206	TonB-dependent receptor
AMD18_RS18670	COG0720	synthase
AMD18_RS18680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AMD18_RS18690	COG1956	GAF domain-containing protein
AMD18_RS18700	COG2819	hydrolase of the alpha beta superfamily
AMD18_RS18715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMD18_RS18720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD18_RS18735	COG0339	signal peptide processing
AMD18_RS18785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMD18_RS18790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD18_RS18795	COG1136	(ABC) transporter
AMD18_RS18795	COG4591	ABC-type transport system involved in lipoprotein release permease component
AMD18_RS18800	COG1136	(ABC) transporter
AMD18_RS18800	COG0577	efflux transmembrane transporter activity
AMD18_RS18805	COG0577	efflux transmembrane transporter activity
AMD18_RS18820	COG4191	Histidine kinase
AMD18_RS18825	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMD18_RS18840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AMD18_RS18845	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AMD18_RS18850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AMD18_RS18855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMD18_RS18860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMD18_RS18865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMD18_RS18875	COG0356	it plays a direct role in the translocation of protons across the membrane
AMD18_RS18895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMD18_RS18905	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMD18_RS18950	COG2011	ABC-type metal ion transport system permease component
AMD18_RS18955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMD18_RS18960	COG0697	spore germination
AMD18_RS18965	COG1666	GTP binding
AMD18_RS18975	COG0784	Response regulator, receiver
AMD18_RS18975	COG5002	protein histidine kinase activity
AMD18_RS18975	COG2198	Histidine kinase
AMD18_RS19000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMD18_RS19005	COG1187	pseudouridine synthase activity
AMD18_RS19010	COG2813	Specifically methylates the guanine in position
AMD18_RS19030	COG2202	Pas domain
AMD18_RS19030	COG2205	protein histidine kinase activity
AMD18_RS19050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMD18_RS19055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD18_RS19110	COG0842	Transport permease protein
AMD18_RS19115	COG1131	(ABC) transporter
AMD18_RS19120	COG0025	NhaP-type Na H and K H
AMD18_RS19125	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AMD18_RS19130	COG1573	uracil-dna glycosylase
AMD18_RS19140	COG3384	dioxygenase
AMD18_RS19150	COG0583	DNA-binding transcription factor activity
AMD18_RS19160	COG0667	Aldo Keto reductase
AMD18_RS19190	COG0531	amino acid
AMD18_RS19220	COG3685	Protein conserved in bacteria
AMD18_RS19225	COG3546	catalase activity
AMD18_RS19270	COG1271	oxidase subunit
AMD18_RS19275	COG1294	oxidase, subunit
AMD18_RS19290	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS19295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMD18_RS19315	COG1132	(ABC) transporter
AMD18_RS19330	COG1063	alcohol dehydrogenase
AMD18_RS19405	COG0251	oxidation-reduction process
AMD18_RS19435	COG0840	transmembrane signaling receptor activity
AMD18_RS19455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMD18_RS19495	COG0024	Methionine aminopeptidase
AMD18_RS19515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMD18_RS19520	COG1490	D-aminoacyl-tRNA deacylase activity
AMD18_RS19525	COG1560	Kdo2-lipid A biosynthetic process
AMD18_RS19575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AMD18_RS19575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMD18_RS19580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMD18_RS19585	COG0242	peptide deformylase activity
AMD18_RS19590	COG1652	LysM domain
AMD18_RS19595	COG0758	DNA mediated transformation
AMD18_RS19600	COG2922	Belongs to the Smg family
AMD18_RS19615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMD18_RS19615	COG1754	DNA topoisomerase type I activity
AMD18_RS19620	COG0009	L-threonylcarbamoyladenylate synthase
AMD18_RS19635	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS19645	COG0616	signal peptide processing
AMD18_RS19650	COG0534	Mate efflux family protein
AMD18_RS19670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AMD18_RS19675	COG0625	glutathione transferase activity
AMD18_RS19690	COG1252	NADH dehydrogenase
AMD18_RS19695	COG2860	membrane
AMD18_RS19700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMD18_RS19705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMD18_RS19710	COG3437	response regulator, receiver
AMD18_RS19715	COG2177	Part of the ABC transporter FtsEX involved in
AMD18_RS19720	COG2884	Cell division ATP-binding protein ftsE
AMD18_RS19725	COG0513	Belongs to the DEAD box helicase family
AMD18_RS19730	COG3118	belongs to the thioredoxin family
AMD18_RS19735	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AMD18_RS19740	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AMD18_RS19745	COG0583	DNA-binding transcription factor activity
AMD18_RS19790	COG1518	maintenance of DNA repeat elements
AMD18_RS19795	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AMD18_RS19805	COG1652	LysM domain
AMD18_RS19810	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AMD18_RS19810	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AMD18_RS19815	COG1473	amidohydrolase
AMD18_RS19820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD18_RS19825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD18_RS19835	COG5383	Protein conserved in bacteria
AMD18_RS19875	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AMD18_RS19880	COG3023	N-Acetylmuramoyl-L-alanine amidase
AMD18_RS19890	COG4948	Mandelate Racemase Muconate Lactonizing
AMD18_RS19900	COG0531	amino acid
AMD18_RS19915	COG4682	membrane
AMD18_RS19920	COG2133	pyrroloquinoline quinone binding
AMD18_RS19930	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AMD18_RS19935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMD18_RS19945	COG1610	YqeY-like protein
AMD18_RS19950	COG1295	ribonuclease BN
AMD18_RS19955	COG0358	DNA primase activity
AMD18_RS19970	COG0109	protoheme IX farnesyltransferase activity
AMD18_RS20000	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AMD18_RS20010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AMD18_RS20055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMD18_RS20060	COG0739	heme binding
AMD18_RS20065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AMD18_RS20075	COG2211	Major facilitator Superfamily
AMD18_RS20080	COG0708	Exodeoxyribonuclease III
AMD18_RS20085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMD18_RS20095	COG1192	Involved in chromosome partitioning
AMD18_RS20100	COG1475	DNA binding
AMD18_RS20115	COG0463	Glycosyl transferase, family 2
AMD18_RS20135	COG0756	dUTP diphosphatase activity
AMD18_RS20140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMD18_RS20145	COG2003	Belongs to the UPF0758 family
AMD18_RS20150	COG0018	arginyl-trna synthetase
AMD18_RS20165	COG4221	oxidoreductase activity
AMD18_RS20170	COG2755	lipolytic protein G-D-S-L family
AMD18_RS20170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMD18_RS20180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD18_RS20190	COG1166	arginine decarboxylase activity
AMD18_RS20195	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AMD18_RS20235	COG0606	chelatase, subunit chli
AMD18_RS20250	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AMD18_RS20285	COG1690	Belongs to the RtcB family
AMD18_RS20325	COG1090	epimerase
AMD18_RS20335	COG0642	Histidine kinase
AMD18_RS20355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD18_RS20380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMD18_RS20385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMD18_RS20400	COG0753	catalase activity
AMD18_RS20415	COG2197	response regulator
AMD18_RS20420	COG4585	Histidine kinase
AMD18_RS20425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD18_RS20430	COG1136	(ABC) transporter
AMD18_RS20455	COG0697	spore germination
AMD18_RS20470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD18_RS20475	COG0180	Tryptophanyl-tRNA synthetase
AMD18_RS20480	COG3237	CsbD-like
AMD18_RS20520	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMD18_RS20535	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMD18_RS20580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMD18_RS20600	COG1199	ATP-dependent helicase activity
AMD18_RS20615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMD18_RS20675	COG0625	glutathione transferase activity
AMD18_RS20715	COG4555	ABC transporter
AMD18_RS20725	COG1476	TRANSCRIPTIONal
AMD18_RS20770	COG0633	Ferredoxin
AMD18_RS20770	COG0543	2 iron, 2 sulfur cluster binding
AMD18_RS20775	COG1131	(ABC) transporter
AMD18_RS20780	COG0842	Transport permease protein
AMD18_RS20790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMD18_RS20820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD18_RS20825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD18_RS20835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMD18_RS20835	COG1042	CoA-binding domain protein
AMD18_RS20835	COG0045	succinate-CoA ligase (ADP-forming) activity
AMD18_RS20840	COG2239	Acts as a magnesium transporter
AMD18_RS20855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AMD18_RS20860	COG3387	PFAM Glycoside hydrolase 15-related
AMD18_RS20875	COG3100	YcgL domain-containing protein
AMD18_RS20880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMD18_RS20890	COG0463	Glycosyl transferase, family 2
AMD18_RS20905	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS20945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD18_RS20960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMD18_RS20985	COG1506	peptidase
AMD18_RS20985	COG4946	Tricorn protease homolog
AMD18_RS20985	COG0823	Involved in the tonB-independent uptake of proteins
AMD18_RS21000	COG0408	coproporphyrinogen oxidase activity
AMD18_RS21035	COG2815	serine threonine protein kinase
AMD18_RS21035	COG0515	serine threonine protein kinase
AMD18_RS21040	COG0631	protein serine/threonine phosphatase activity
AMD18_RS21200	COG0210	DNA helicase
AMD18_RS21215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD18_RS21220	COG0583	DNA-binding transcription factor activity
AMD18_RS21225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMD18_RS21235	COG2159	amidohydrolase
AMD18_RS21255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD18_RS21275	COG0357	Ribosomal RNA small subunit methyltransferase G
AMD18_RS21280	COG3540	Alkaline phosphatase
AMD18_RS21290	COG2091	lysine biosynthetic process via aminoadipic acid
AMD18_RS21310	COG0708	Exodeoxyribonuclease III
AMD18_RS21315	COG1846	Transcriptional regulator
AMD18_RS21315	COG1940	carbohydrate kinase activity
AMD18_RS21325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD18_RS21335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMD18_RS21340	COG3162	membrane
AMD18_RS21350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMD18_RS21380	COG3507	Belongs to the glycosyl hydrolase 43 family
AMD18_RS21400	COG1028	Short-chain dehydrogenase reductase Sdr
AMD18_RS21405	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMD18_RS21410	COG4948	Mandelate Racemase Muconate Lactonizing
AMD18_RS21420	COG3254	rhamnose metabolic process
AMD18_RS21425	COG0738	Major facilitator superfamily
AMD18_RS21430	COG1414	Transcriptional regulator
AMD18_RS21435	COG1971	Probably functions as a manganese efflux pump
AMD18_RS21440	COG2205	protein histidine kinase activity
AMD18_RS21455	COG3459	Glycosyltransferase 36 associated
AMD18_RS21460	COG2211	Major facilitator Superfamily
AMD18_RS21465	COG3265	gluconokinase activity
AMD18_RS21470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD18_RS21490	COG2911	Protein conserved in bacteria
AMD18_RS21495	COG0729	surface antigen
AMD18_RS21535	COG0752	glycyl-tRNA synthetase alpha subunit
AMD18_RS21540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD18_RS21550	COG0519	Catalyzes the synthesis of GMP from XMP
AMD18_RS21550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD18_RS21560	COG0805	protein transport
AMD18_RS21565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMD18_RS21570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMD18_RS21580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AMD18_RS21600	COG2974	May be involved in recombination
AMD18_RS21605	COG0037	tRNA processing
AMD18_RS21610	COG2115	Belongs to the xylose isomerase family
AMD18_RS21620	COG3661	Belongs to the glycosyl hydrolase 67 family
AMD18_RS21630	COG4948	Mandelate Racemase Muconate Lactonizing
AMD18_RS21640	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD18_RS21645	COG0246	Mannitol dehydrogenase
AMD18_RS21720	COG3386	PFAM SMP-30 Gluconolaconase
AMD18_RS21730	COG3250	beta-galactosidase activity
AMD18_RS21735	COG1904	glucuronate isomerase
AMD18_RS21755	COG3693	PFAM glycoside hydrolase, family 10
AMD18_RS21770	COG2211	Major facilitator Superfamily
AMD18_RS21810	COG2937	Belongs to the GPAT DAPAT family
AMD18_RS21845	COG0284	orotidine-5'-phosphate decarboxylase activity
AMD18_RS21850	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AMD18_RS21855	COG3132	Protein of unknown function, DUF480
AMD18_RS21870	COG0210	DNA helicase
AMD18_RS21875	COG1435	thymidine kinase activity
AMD18_RS21885	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AMD18_RS21895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMD18_RS21930	COG3135	benzoate transporter
AMD18_RS21950	COG0676	glucose-6-phosphate 1-epimerase activity
AMD18_RS21960	COG3012	SEC-C Motif Domain Protein
AMD18_RS21965	COG0730	response to heat
AMD18_RS21985	COG0302	gtp cyclohydrolase
AMD18_RS22000	COG1566	PFAM secretion protein HlyD family protein
AMD18_RS22010	COG1289	transmembrane transporter activity
AMD18_RS22015	COG0477	Major facilitator Superfamily
AMD18_RS22025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD18_RS22045	COG4691	Plasmid stability protein
AMD18_RS22050	COG1487	ribonuclease activity
AMD18_RS22075	COG0564	pseudouridine synthase activity
AMD18_RS22110	COG0439	Biotin carboxylase
AMD18_RS22145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AMD18_RS22150	COG1074	ATP-dependent DNA helicase activity
AMD18_RS22155	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AMD18_RS22170	COG1127	ABC transporter
AMD18_RS22175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMD18_RS22180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMD18_RS22195	COG2853	Lipoprotein
AMD18_RS22205	COG0386	Belongs to the glutathione peroxidase family
AMD18_RS22215	COG1322	Protein conserved in bacteria
AMD18_RS22220	COG0604	alcohol dehydrogenase
AMD18_RS22235	COG0625	glutathione transferase activity
AMD18_RS22245	COG0531	amino acid
AMD18_RS22250	COG3537	Alpha-1,2-mannosidase
AMD18_RS22260	COG3706	GGDEF domain
AMD18_RS22265	COG3835	regulator
AMD18_RS22270	COG1929	Belongs to the glycerate kinase type-1 family
AMD18_RS22275	COG2271	Major facilitator Superfamily
AMD18_RS22290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AMD18_RS22295	COG0861	Integral membrane protein TerC family
AMD18_RS22305	COG0584	glycerophosphoryl diester phosphodiesterase
AMD18_RS22320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AMD18_RS22325	COG0726	polysaccharide deacetylase
AMD18_RS22335	COG0706	membrane insertase activity
AMD18_RS22340	COG0594	ribonuclease P activity
AMD18_RS22365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AMD18_RS22400	COG3318	Belongs to the UPF0149 family
AMD18_RS22400	COG3012	SEC-C Motif Domain Protein
AMD18_RS22485	COG0653	protein targeting
AMD18_RS22955	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AMD18_RS23105	COG1960	acyl-CoA dehydrogenase activity
AMD18_RS23110	COG1960	acyl-CoA dehydrogenase activity
AMD18_RS23115	COG1960	acyl-CoA dehydrogenase activity
AMD18_RS23280	COG3002	Belongs to the UPF0753 family
AMD18_RS23340	COG0582	viral genome integration into host DNA
AMD18_RS23935	COG0596	Alpha beta hydrolase
AMD18_RS24100	COG2972	Histidine kinase