locus-tag	class	description
AC612_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AC612_RS00025	COG0187	DNA topoisomerase II activity
AC612_RS00035	COG0501	Belongs to the peptidase M48B family
AC612_RS00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AC612_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC612_RS00130	COG0793	Belongs to the peptidase S41A family
AC612_RS00135	COG4942	peptidase
AC612_RS00145	COG2234	aminopeptidase activity
AC612_RS00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC612_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC612_RS00170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC612_RS00180	COG1064	alcohol dehydrogenase
AC612_RS00190	COG0493	'glutamate synthase
AC612_RS00195	COG0070	glutamate synthase
AC612_RS00195	COG0069	glutamate synthase activity
AC612_RS00195	COG0067	glutamate synthase
AC612_RS00285	COG1111	helicase
AC612_RS00285	COG1205	dead DEAH box helicase
AC612_RS00290	COG1272	protein, Hemolysin III
AC612_RS00310	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS00315	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS00340	COG2249	NAD(P)H dehydrogenase (quinone) activity
AC612_RS00365	COG3039	Transposase
AC612_RS00390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC612_RS00405	COG0517	IMP dehydrogenase activity
AC612_RS00405	COG1125	glycine betaine transport
AC612_RS00420	COG1119	ATPase activity
AC612_RS00430	COG1752	Esterase of the alpha-beta hydrolase superfamily
AC612_RS00440	COG1522	sequence-specific DNA binding
AC612_RS00445	COG3186	Phenylalanine-4-hydroxylase
AC612_RS00455	COG2755	lipolytic protein G-D-S-L family
AC612_RS00465	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS00470	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AC612_RS00485	COG1609	Transcriptional regulator
AC612_RS00490	COG3507	Belongs to the glycosyl hydrolase 43 family
AC612_RS00505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC612_RS00515	COG0657	acetylesterase activity
AC612_RS00515	COG2755	lipolytic protein G-D-S-L family
AC612_RS00535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC612_RS00540	COG0366	Alpha amylase catalytic
AC612_RS00545	COG0366	Alpha amylase catalytic
AC612_RS00570	COG3039	Transposase
AC612_RS00590	COG3328	transposase activity
AC612_RS00595	COG3039	Transposase
AC612_RS00610	COG3328	transposase activity
AC612_RS00635	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AC612_RS00640	COG3710	Transcriptional regulator
AC612_RS00660	COG2197	response regulator
AC612_RS00665	COG4585	Histidine kinase
AC612_RS00680	COG1304	FMN binding
AC612_RS00705	COG1012	belongs to the aldehyde dehydrogenase family
AC612_RS00715	COG3039	Transposase
AC612_RS00725	COG4772	TonB-dependent receptor
AC612_RS00735	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AC612_RS00770	COG0714	Associated with various cellular activities
AC612_RS00815	COG0477	Major facilitator Superfamily
AC612_RS00825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC612_RS00850	COG3039	Transposase
AC612_RS00880	COG3237	CsbD-like
AC612_RS00890	COG3039	Transposase
AC612_RS00900	COG0489	protein tyrosine kinase activity
AC612_RS00905	COG2062	phosphohistidine phosphatase, SixA
AC612_RS00915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC612_RS00960	COG1968	undecaprenyl-diphosphatase activity
AC612_RS00970	COG0174	glutamine synthetase
AC612_RS00975	COG0347	Belongs to the P(II) protein family
AC612_RS00980	COG0004	ammonium transporteR
AC612_RS00985	COG3852	Histidine kinase
AC612_RS00990	COG2204	response regulator
AC612_RS00995	COG2032	superoxide dismutase activity
AC612_RS01000	COG2032	superoxide dismutase activity
AC612_RS01010	COG3039	Transposase
AC612_RS01025	COG0183	Belongs to the thiolase family
AC612_RS01060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC612_RS01065	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AC612_RS01070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AC612_RS01085	COG0028	Belongs to the TPP enzyme family
AC612_RS01090	COG2205	protein histidine kinase activity
AC612_RS01115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AC612_RS01130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC612_RS01140	COG0596	Alpha beta hydrolase
AC612_RS01145	COG0727	PFAM Uncharacterised protein family (UPF0153)
AC612_RS01150	COG0318	PFAM AMP-dependent synthetase and ligase
AC612_RS01155	COG0745	RESPONSE REGULATOR receiver
AC612_RS01165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC612_RS01195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC612_RS01205	COG0564	pseudouridine synthase activity
AC612_RS01225	COG1446	asparaginase
AC612_RS01230	COG0339	signal peptide processing
AC612_RS01265	COG0475	glutathione-regulated potassium exporter activity
AC612_RS01270	COG0583	DNA-binding transcription factor activity
AC612_RS01275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AC612_RS01280	COG2224	Isocitrate lyase
AC612_RS01300	COG3039	Transposase
AC612_RS01335	COG4770	biotin carboxylase activity
AC612_RS01340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC612_RS01345	COG1960	acyl-CoA dehydrogenase activity
AC612_RS01410	COG0697	spore germination
AC612_RS01420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AC612_RS01425	COG1846	Transcriptional regulator
AC612_RS01430	COG1764	response to oxidative stress
AC612_RS01460	COG2130	NADP-dependent
AC612_RS01475	COG1187	pseudouridine synthase activity
AC612_RS01490	COG1643	Atp-dependent helicase
AC612_RS01500	COG4807	Protein conserved in bacteria
AC612_RS01505	COG2351	hydroxyisourate hydrolase activity
AC612_RS01510	COG2072	flavoprotein involved in K transport
AC612_RS01530	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AC612_RS01540	COG0583	DNA-binding transcription factor activity
AC612_RS01575	COG2252	PERMEase
AC612_RS01620	COG0583	DNA-binding transcription factor activity
AC612_RS01625	COG2814	Major facilitator Superfamily
AC612_RS01635	COG2267	carboxylic ester hydrolase activity
AC612_RS01640	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AC612_RS01645	COG1902	pentaerythritol trinitrate reductase activity
AC612_RS01665	COG0745	RESPONSE REGULATOR receiver
AC612_RS01670	COG2205	protein histidine kinase activity
AC612_RS01675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC612_RS01695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC612_RS01700	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AC612_RS01705	COG0583	DNA-binding transcription factor activity
AC612_RS01740	COG0702	epimerase
AC612_RS01745	COG1733	regulation of RNA biosynthetic process
AC612_RS01765	COG3039	Transposase
AC612_RS01790	COG3328	transposase activity
AC612_RS01810	COG3039	Transposase
AC612_RS01820	COG0129	dihydroxy-acid dehydratase activity
AC612_RS01835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AC612_RS01895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AC612_RS01900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AC612_RS01925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AC612_RS01930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AC612_RS01940	COG3485	protocatechuate 3,4-dioxygenase
AC612_RS01945	COG3485	protocatechuate 3,4-dioxygenase
AC612_RS01955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC612_RS01960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AC612_RS01975	COG1414	Transcriptional regulator
AC612_RS01985	COG0657	acetylesterase activity
AC612_RS01995	COG0445	tRNA wobble uridine modification
AC612_RS02005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AC612_RS02040	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS02045	COG2267	carboxylic ester hydrolase activity
AC612_RS02055	COG0156	8-amino-7-oxononanoate synthase activity
AC612_RS02060	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AC612_RS02065	COG1040	competence protein
AC612_RS02075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AC612_RS02115	COG3039	Transposase
AC612_RS02180	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC612_RS02255	COG3264	Mechanosensitive ion channel
AC612_RS02255	COG1511	domain protein
AC612_RS02260	COG1368	sulfuric ester hydrolase activity
AC612_RS02265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC612_RS02275	COG2354	Protein conserved in bacteria
AC612_RS02285	COG0297	glycogen (starch) synthase activity
AC612_RS02290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC612_RS02295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC612_RS02320	COG0702	epimerase
AC612_RS02325	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS02360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC612_RS02365	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS02375	COG0513	Belongs to the DEAD box helicase family
AC612_RS02380	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC612_RS02395	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AC612_RS02405	COG3483	tryptophan 2,3-dioxygenase activity
AC612_RS02410	COG3104	oligopeptide transport
AC612_RS02450	COG1320	monovalent cation:proton antiporter activity
AC612_RS02455	COG2212	antiporter activity
AC612_RS02465	COG0651	ATP synthesis coupled electron transport
AC612_RS02470	COG1006	Multisubunit Na H antiporter MnhC subunit
AC612_RS02475	COG2111	Na H antiporter
AC612_RS02475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC612_RS02500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AC612_RS02505	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AC612_RS02520	COG0456	acetyltransferase
AC612_RS02525	COG1597	lipid kinase activity
AC612_RS02550	COG3039	Transposase
AC612_RS02575	COG3039	Transposase
AC612_RS02595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AC612_RS02600	COG0134	indole-3-glycerol-phosphate synthase activity
AC612_RS02610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC612_RS02615	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AC612_RS02625	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AC612_RS02635	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AC612_RS02650	COG1051	belongs to the nudix hydrolase family
AC612_RS02690	COG0316	Belongs to the HesB IscA family
AC612_RS02705	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC612_RS02720	COG2814	Major facilitator Superfamily
AC612_RS02730	COG2814	Major facilitator Superfamily
AC612_RS02735	COG1289	transmembrane transporter activity
AC612_RS02740	COG0151	Belongs to the GarS family
AC612_RS02750	COG0138	bifunctional purine biosynthesis protein purh
AC612_RS02755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC612_RS02765	COG0671	phosphoesterase, PA-phosphatase related
AC612_RS02765	COG2453	phosphatase
AC612_RS02790	COG4589	Belongs to the CDS family
AC612_RS02795	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AC612_RS02825	COG2264	protein methyltransferase activity
AC612_RS02845	COG0439	Biotin carboxylase
AC612_RS02855	COG0511	ligase activity, forming carbon-carbon bonds
AC612_RS02860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AC612_RS02870	COG1324	tolerance protein
AC612_RS02880	COG2356	endonuclease I
AC612_RS02890	COG0459	protein refolding
AC612_RS02905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AC612_RS02920	COG3386	PFAM SMP-30 Gluconolaconase
AC612_RS02930	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AC612_RS02935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AC612_RS02960	COG0778	Nitroreductase
AC612_RS02965	COG2353	YceI-like domain
AC612_RS02995	COG3052	prosthetic group binding
AC612_RS03020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AC612_RS03030	COG1802	Transcriptional regulator
AC612_RS03095	COG3328	transposase activity
AC612_RS03125	COG3039	Transposase
AC612_RS03145	COG4221	oxidoreductase activity
AC612_RS03160	COG4221	oxidoreductase activity
AC612_RS03170	COG0435	Glutathione S-transferase
AC612_RS03205	COG1506	peptidase
AC612_RS03205	COG0823	Involved in the tonB-independent uptake of proteins
AC612_RS03250	COG0697	spore germination
AC612_RS03255	COG4305	rare lipoprotein A
AC612_RS03260	COG5297	Belongs to the glycosyl hydrolase family 6
AC612_RS03270	COG1113	amino acid transport
AC612_RS03290	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AC612_RS03340	COG0840	transmembrane signaling receptor activity
AC612_RS03345	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC612_RS03345	COG5297	Belongs to the glycosyl hydrolase family 6
AC612_RS03350	COG0659	secondary active sulfate transmembrane transporter activity
AC612_RS03380	COG2943	transferase activity, transferring hexosyl groups
AC612_RS03390	COG3275	phosphorelay sensor kinase activity
AC612_RS03400	COG0181	hydroxymethylbilane synthase activity
AC612_RS03430	COG1505	serine-type exopeptidase activity
AC612_RS03435	COG0436	Aminotransferase
AC612_RS03445	COG2832	Protein of unknown function (DUF454)
AC612_RS03455	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AC612_RS03465	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AC612_RS03470	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AC612_RS03475	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AC612_RS03500	COG2226	methyltransferase
AC612_RS03505	COG5001	Diguanylate cyclase
AC612_RS03505	COG3300	MHYT domain
AC612_RS03510	COG0308	aminopeptidase N
AC612_RS03565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC612_RS03570	COG1077	Cell shape determining protein MreB Mrl
AC612_RS03575	COG1792	Involved in formation and maintenance of cell shape
AC612_RS03590	COG0772	Belongs to the SEDS family
AC612_RS03600	COG2951	lytic endotransglycosylase activity
AC612_RS03605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AC612_RS03615	COG1686	Belongs to the peptidase S11 family
AC612_RS03625	COG2921	Belongs to the UPF0250 family
AC612_RS03630	COG0321	lipoyl(octanoyl) transferase activity
AC612_RS03635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AC612_RS03660	COG1056	cytidyltransferase-related domain
AC612_RS03660	COG1051	belongs to the nudix hydrolase family
AC612_RS03695	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AC612_RS03700	COG0673	inositol 2-dehydrogenase activity
AC612_RS03705	COG2823	Periplasmic or secreted lipoprotein
AC612_RS03710	COG4251	negative regulation of phosphorylation
AC612_RS03715	COG0784	Response regulator, receiver
AC612_RS03720	COG4191	Histidine kinase
AC612_RS03725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AC612_RS03785	COG1459	type II secretion system
AC612_RS03790	COG2165	general secretion pathway protein
AC612_RS03805	COG4795	General secretion pathway protein
AC612_RS03835	COG3250	beta-galactosidase activity
AC612_RS03850	COG2188	Transcriptional regulator
AC612_RS03860	COG1609	Transcriptional regulator
AC612_RS03865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AC612_RS03870	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AC612_RS03885	COG0617	tRNA 3'-terminal CCA addition
AC612_RS03890	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AC612_RS03895	COG1012	belongs to the aldehyde dehydrogenase family
AC612_RS03900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC612_RS03915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC612_RS03930	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AC612_RS03955	COG2205	protein histidine kinase activity
AC612_RS03985	COG3791	Glutathione-dependent formaldehyde-activating
AC612_RS04000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC612_RS04020	COG0488	(ABC) transporter
AC612_RS04030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC612_RS04035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AC612_RS04045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC612_RS04045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC612_RS04065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AC612_RS04070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC612_RS04075	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AC612_RS04100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AC612_RS04105	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AC612_RS04110	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AC612_RS04115	COG2205	protein histidine kinase activity
AC612_RS04120	COG0745	RESPONSE REGULATOR receiver
AC612_RS04125	COG0277	FAD linked oxidase domain protein
AC612_RS04130	COG1988	membrane-bound metal-dependent
AC612_RS04135	COG0792	nuclease activity
AC612_RS04165	COG0275	rRNA processing
AC612_RS04170	COG3116	cell division
AC612_RS04180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AC612_RS04185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC612_RS04190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC612_RS04200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AC612_RS04205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC612_RS04210	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC612_RS04215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AC612_RS04230	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AC612_RS04240	COG0739	heme binding
AC612_RS04245	COG0653	protein targeting
AC612_RS04250	COG0494	nUDIX hydrolase
AC612_RS04260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC612_RS04280	COG3321	synthase
AC612_RS04280	COG0604	alcohol dehydrogenase
AC612_RS04280	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS04305	COG0366	Alpha amylase catalytic
AC612_RS04345	COG2226	methyltransferase
AC612_RS04350	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AC612_RS04360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AC612_RS04400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AC612_RS04410	COG4106	trans-aconitate 2-methyltransferase activity
AC612_RS04415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AC612_RS04425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC612_RS04430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AC612_RS04440	COG0667	Aldo Keto reductase
AC612_RS04450	COG4771	TonB-dependent receptor
AC612_RS04470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC612_RS04475	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AC612_RS04485	COG2175	clavaminate synthase activity
AC612_RS04495	COG4181	ATPase activity
AC612_RS04510	COG0642	Histidine kinase
AC612_RS04520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AC612_RS04540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AC612_RS04545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AC612_RS04560	COG3829	transcription factor binding
AC612_RS04570	COG1116	anion transmembrane transporter activity
AC612_RS04575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC612_RS04585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC612_RS04590	COG0431	NADPH-dependent FMN reductase
AC612_RS04610	COG0747	negative chemotaxis
AC612_RS04620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC612_RS04630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AC612_RS04635	COG2967	ApaG domain
AC612_RS04640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AC612_RS04645	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AC612_RS04650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC612_RS04655	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AC612_RS04680	COG0123	including yeast histone deacetylase and acetoin utilization protein
AC612_RS04685	COG2096	Adenosyltransferase
AC612_RS04700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC612_RS04705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC612_RS04735	COG3384	dioxygenase
AC612_RS04740	COG0583	DNA-binding transcription factor activity
AC612_RS04755	COG1024	Enoyl-CoA hydratase
AC612_RS04785	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AC612_RS04810	COG0697	spore germination
AC612_RS04820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC612_RS04845	COG2197	response regulator
AC612_RS04855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC612_RS04865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AC612_RS04870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC612_RS04880	COG0583	DNA-binding transcription factor activity
AC612_RS04885	COG3634	alkyl hydroperoxide reductase activity
AC612_RS04895	COG2890	protein-(glutamine-N5) methyltransferase activity
AC612_RS04915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC612_RS04915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC612_RS04935	COG3039	Transposase
AC612_RS04950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC612_RS04995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC612_RS05000	COG1404	Belongs to the peptidase S8 family
AC612_RS05005	COG1404	Belongs to the peptidase S8 family
AC612_RS05010	COG1404	Belongs to the peptidase S8 family
AC612_RS05015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AC612_RS05040	COG1295	ribonuclease BN
AC612_RS05045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC612_RS05050	COG1254	Belongs to the acylphosphatase family
AC612_RS05065	COG0521	Mo-molybdopterin cofactor biosynthetic process
AC612_RS05075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AC612_RS05080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AC612_RS05090	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AC612_RS05095	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AC612_RS05105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC612_RS05110	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AC612_RS05115	COG0193	aminoacyl-tRNA hydrolase activity
AC612_RS05120	COG0012	GTP binding
AC612_RS05140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC612_RS05155	COG0250	Participates in transcription elongation, termination and antitermination
AC612_RS05160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AC612_RS05165	COG0081	regulation of translation
AC612_RS05170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AC612_RS05175	COG0222	ribosome binding
AC612_RS05180	COG0085	RNA polymerase activity
AC612_RS05185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AC612_RS05190	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AC612_RS05195	COG0049	tRNA binding
AC612_RS05200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AC612_RS05205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC612_RS05210	COG0051	transcription antitermination factor activity, RNA binding
AC612_RS05215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AC612_RS05220	COG0088	Forms part of the polypeptide exit tunnel
AC612_RS05225	COG0089	rRNA binding
AC612_RS05230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AC612_RS05235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AC612_RS05245	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AC612_RS05250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AC612_RS05255	COG0255	Belongs to the universal ribosomal protein uL29 family
AC612_RS05260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AC612_RS05270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AC612_RS05275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AC612_RS05285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AC612_RS05290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AC612_RS05295	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AC612_RS05305	COG1841	ribosomal large subunit assembly
AC612_RS05310	COG0200	Binds to the 23S rRNA
AC612_RS05315	COG0201	protein transport
AC612_RS05340	COG0203	ribosomal protein L17
AC612_RS05345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AC612_RS05365	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AC612_RS05380	COG0154	amidase activity
AC612_RS05390	COG1217	gtp-binding protein TYPA
AC612_RS05395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC612_RS05400	COG0039	L-malate dehydrogenase activity
AC612_RS05405	COG0625	glutathione transferase activity
AC612_RS05425	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC612_RS05425	COG1902	pentaerythritol trinitrate reductase activity
AC612_RS05430	COG0604	alcohol dehydrogenase
AC612_RS05460	COG0156	8-amino-7-oxononanoate synthase activity
AC612_RS05470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AC612_RS05475	COG4208	sulfate ABC transporter
AC612_RS05480	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AC612_RS05510	COG0406	alpha-ribazole phosphatase activity
AC612_RS05515	COG0285	dihydrofolate synthase activity
AC612_RS05535	COG2833	Protein of unknown function (DUF455)
AC612_RS05555	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC612_RS05560	COG0671	phosphoesterase, PA-phosphatase related
AC612_RS05565	COG0438	transferase activity, transferring glycosyl groups
AC612_RS05575	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AC612_RS05590	COG4783	chaperone-mediated protein folding
AC612_RS05605	COG0473	3-isopropylmalate dehydrogenase activity
AC612_RS05645	COG0544	peptidyl-prolyl cis-trans isomerase activity
AC612_RS05655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AC612_RS05685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC612_RS05700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC612_RS05710	COG0328	RNA-DNA hybrid ribonuclease activity
AC612_RS05715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC612_RS05720	COG0631	protein serine/threonine phosphatase activity
AC612_RS05735	COG0859	PFAM glycosyl transferase family 9
AC612_RS05740	COG3642	lipopolysaccharide core region biosynthetic process
AC612_RS05745	COG1234	tRNA 3'-trailer cleavage
AC612_RS05750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AC612_RS05760	COG0315	cyclic pyranopterin monophosphate synthase activity
AC612_RS05765	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AC612_RS05770	COG0314	molybdopterin synthase activity
AC612_RS05805	COG3328	transposase activity
AC612_RS05825	COG3328	transposase activity
AC612_RS05845	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AC612_RS05850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AC612_RS05855	COG0537	adenosine 5'-monophosphoramidase activity
AC612_RS05875	COG0714	Associated with various cellular activities
AC612_RS05900	COG0424	maF-like protein
AC612_RS05905	COG1399	metal-binding, possibly nucleic acid-binding protein
AC612_RS05915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC612_RS05925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AC612_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS05945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AC612_RS05950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AC612_RS05975	COG3829	transcription factor binding
AC612_RS06020	COG2373	Large extracellular alpha-helical protein
AC612_RS06040	COG4953	penicillin-binding protein 1C
AC612_RS06050	COG0678	peroxiredoxin activity
AC612_RS06070	COG0330	HflC and HflK could
AC612_RS06075	COG0330	HflC and HflK could
AC612_RS06085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AC612_RS06100	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS06105	COG1309	transcriptional regulator
AC612_RS06115	COG3328	transposase activity
AC612_RS06120	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AC612_RS06125	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AC612_RS06135	COG3039	Transposase
AC612_RS06140	COG0732	type I restriction modification DNA specificity domain
AC612_RS06155	COG3039	Transposase
AC612_RS06160	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AC612_RS06195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC612_RS06205	COG3387	PFAM Glycoside hydrolase 15-related
AC612_RS06210	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS06220	COG3328	transposase activity
AC612_RS06230	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS06245	COG0492	ferredoxin-NADP+ reductase activity
AC612_RS06280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC612_RS06285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC612_RS06290	COG2080	2 iron, 2 sulfur cluster binding
AC612_RS06325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC612_RS06340	COG0587	DNA-directed DNA polymerase activity
AC612_RS06355	COG1297	OPT oligopeptide transporter protein
AC612_RS06370	COG0823	Involved in the tonB-independent uptake of proteins
AC612_RS06370	COG1506	peptidase
AC612_RS06385	COG2207	Transcriptional regulator
AC612_RS06385	COG1917	Cupin 2, conserved barrel domain protein
AC612_RS06415	COG0753	catalase activity
AC612_RS06420	COG0656	L-ascorbic acid biosynthetic process
AC612_RS06430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC612_RS06430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC612_RS06435	COG2814	Major facilitator Superfamily
AC612_RS06450	COG2194	sulfuric ester hydrolase activity
AC612_RS06465	COG0745	RESPONSE REGULATOR receiver
AC612_RS06470	COG0642	Histidine kinase
AC612_RS06480	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AC612_RS06485	COG2894	cell division
AC612_RS06490	COG0850	regulation of cytokinetic process
AC612_RS06505	COG4585	Histidine kinase
AC612_RS06510	COG2197	response regulator
AC612_RS06525	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AC612_RS06555	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AC612_RS06565	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AC612_RS06585	COG1946	Acyl-CoA thioesterase
AC612_RS06600	COG0824	Thioesterase
AC612_RS06605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AC612_RS06610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AC612_RS06615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AC612_RS06620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AC612_RS06625	COG0268	Binds directly to 16S ribosomal RNA
AC612_RS06635	COG0196	riboflavin kinase activity
AC612_RS06640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AC612_RS06645	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AC612_RS06650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AC612_RS06680	COG3328	transposase activity
AC612_RS06700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AC612_RS06705	COG1845	cytochrome c oxidase, subunit III
AC612_RS06710	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AC612_RS06730	COG3328	transposase activity
AC612_RS06740	COG3152	Membrane
AC612_RS06750	COG2207	Transcriptional regulator
AC612_RS06755	COG0326	Molecular chaperone. Has ATPase activity
AC612_RS06765	COG1366	Belongs to the anti-sigma-factor antagonist family
AC612_RS06770	COG1366	Belongs to the anti-sigma-factor antagonist family
AC612_RS06775	COG2172	sigma factor antagonist activity
AC612_RS06800	COG4771	TonB-dependent receptor
AC612_RS06810	COG5507	3-demethylubiquinone-9 3-methyltransferase
AC612_RS06815	COG2205	protein histidine kinase activity
AC612_RS06825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AC612_RS06830	COG4999	Histidine kinase
AC612_RS06830	COG3850	Histidine kinase
AC612_RS06830	COG3437	response regulator, receiver
AC612_RS06830	COG2205	protein histidine kinase activity
AC612_RS06835	COG0784	Response regulator, receiver
AC612_RS06835	COG4191	Histidine kinase
AC612_RS06850	COG3328	transposase activity
AC612_RS06860	COG3039	Transposase
AC612_RS06875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AC612_RS06885	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AC612_RS06910	COG0534	Mate efflux family protein
AC612_RS06915	COG0335	large ribosomal subunit rRNA binding
AC612_RS06920	COG0336	Belongs to the RNA methyltransferase TrmD family
AC612_RS06925	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AC612_RS06930	COG0228	four-way junction DNA binding
AC612_RS06945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AC612_RS06950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC612_RS06970	COG3328	transposase activity
AC612_RS06995	COG3250	beta-galactosidase activity
AC612_RS07000	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AC612_RS07020	COG1960	acyl-CoA dehydrogenase activity
AC612_RS07025	COG1024	Enoyl-CoA hydratase
AC612_RS07070	COG0237	dephospho-CoA kinase activity
AC612_RS07075	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AC612_RS07080	COG1459	type II secretion system
AC612_RS07120	COG0045	succinate-CoA ligase (ADP-forming) activity
AC612_RS07125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AC612_RS07130	COG3328	transposase activity
AC612_RS07140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC612_RS07140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AC612_RS07150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC612_RS07155	COG0564	pseudouridine synthase activity
AC612_RS07170	COG3011	Protein conserved in bacteria
AC612_RS07175	COG0840	transmembrane signaling receptor activity
AC612_RS07195	COG3387	PFAM Glycoside hydrolase 15-related
AC612_RS07200	COG1877	trehalose-phosphatase activity
AC612_RS07240	COG2827	Endonuclease containing a URI domain
AC612_RS07250	COG4771	TonB-dependent receptor
AC612_RS07255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC612_RS07260	COG0667	Aldo Keto reductase
AC612_RS07265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC612_RS07270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC612_RS07275	COG1116	anion transmembrane transporter activity
AC612_RS07280	COG0542	response to heat
AC612_RS07285	COG4206	TonB-dependent receptor
AC612_RS07310	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC612_RS07320	COG1492	cobalamin metabolic process
AC612_RS07330	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AC612_RS07355	COG0019	diaminopimelate decarboxylase activity
AC612_RS07370	COG4264	IucA IucC family
AC612_RS07380	COG4772	TonB-dependent receptor
AC612_RS07390	COG4651	solute:proton antiporter activity
AC612_RS07390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC612_RS07430	COG0488	(ABC) transporter
AC612_RS07470	COG0477	Major facilitator Superfamily
AC612_RS07485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AC612_RS07500	COG0217	transcriptional regulatory protein
AC612_RS07505	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AC612_RS07510	COG0632	four-way junction helicase activity
AC612_RS07515	COG3158	transport of potassium into the cell
AC612_RS07525	COG2255	four-way junction helicase activity
AC612_RS07530	COG0824	Thioesterase
AC612_RS07540	COG0848	biopolymer transport protein
AC612_RS07550	COG0823	Involved in the tonB-independent uptake of proteins
AC612_RS07555	COG2885	chlorophyll binding
AC612_RS07565	COG0602	queuosine metabolic process
AC612_RS07575	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AC612_RS07580	COG3920	Histidine kinase
AC612_RS07600	COG0840	transmembrane signaling receptor activity
AC612_RS07640	COG0514	ATP-dependent DNA helicase (RecQ)
AC612_RS07645	COG0783	Belongs to the Dps family
AC612_RS07650	COG1643	Atp-dependent helicase
AC612_RS07660	COG0837	glucose binding
AC612_RS07675	COG0535	radical SAM domain protein
AC612_RS07680	COG0535	radical SAM domain protein
AC612_RS07685	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AC612_RS07690	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AC612_RS07700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC612_RS07720	COG1215	transferase activity, transferring glycosyl groups
AC612_RS07725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC612_RS07735	COG1199	ATP-dependent helicase activity
AC612_RS07745	COG1397	ADP-ribosylglycohydrolase
AC612_RS07755	COG0189	ligase activity
AC612_RS07770	COG0835	chemotaxis
AC612_RS07775	COG0840	transmembrane signaling receptor activity
AC612_RS07780	COG2198	Histidine kinase
AC612_RS07780	COG0784	Response regulator, receiver
AC612_RS07780	COG0643	Histidine kinase
AC612_RS07805	COG1446	asparaginase
AC612_RS07810	COG3142	Participates in the control of copper homeostasis
AC612_RS07850	COG3537	Alpha-1,2-mannosidase
AC612_RS07860	COG1486	melibiose metabolic process
AC612_RS07870	COG0531	amino acid
AC612_RS07890	COG1472	Belongs to the glycosyl hydrolase 3 family
AC612_RS07910	COG3858	chitin binding
AC612_RS07910	COG1388	LysM domain
AC612_RS07925	COG0837	glucose binding
AC612_RS07930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AC612_RS07940	COG0494	nUDIX hydrolase
AC612_RS07945	COG1218	3'(2'),5'-bisphosphate nucleotidase
AC612_RS07950	COG3956	TIGRFAM MazG family protein
AC612_RS07955	COG1742	UPF0060 membrane protein
AC612_RS07975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC612_RS07980	COG0509	glycine decarboxylation via glycine cleavage system
AC612_RS08000	COG3328	transposase activity
AC612_RS08025	COG1960	acyl-CoA dehydrogenase activity
AC612_RS08035	COG1309	transcriptional regulator
AC612_RS08040	COG3039	Transposase
AC612_RS08050	COG3328	transposase activity
AC612_RS08055	COG4771	TonB-dependent receptor
AC612_RS08065	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AC612_RS08070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC612_RS08075	COG0463	Glycosyl transferase, family 2
AC612_RS08080	COG0517	IMP dehydrogenase activity
AC612_RS08080	COG0516	GMP reductase activity
AC612_RS08085	COG2982	Protein involved in outer membrane biogenesis
AC612_RS08090	COG1272	protein, Hemolysin III
AC612_RS08095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AC612_RS08100	COG0739	heme binding
AC612_RS08105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC612_RS08110	COG0626	cystathionine gamma-synthase activity
AC612_RS08115	COG0527	aspartate kinase activity
AC612_RS08115	COG0460	homoserine dehydrogenase
AC612_RS08130	COG1760	l-serine dehydratase
AC612_RS08150	COG2353	YceI-like domain
AC612_RS08155	COG0784	Response regulator, receiver
AC612_RS08155	COG2198	Histidine kinase
AC612_RS08155	COG2205	protein histidine kinase activity
AC612_RS08175	COG2814	Major facilitator Superfamily
AC612_RS08180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AC612_RS08190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AC612_RS08195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AC612_RS08200	COG0259	pyridoxamine-phosphate oxidase activity
AC612_RS08210	COG1842	Phage shock protein A
AC612_RS08235	COG0754	glutathionylspermidine amidase activity
AC612_RS08245	COG2814	Major facilitator Superfamily
AC612_RS08355	COG0531	amino acid
AC612_RS08360	COG2197	response regulator
AC612_RS08385	COG3328	transposase activity
AC612_RS08395	COG1113	amino acid transport
AC612_RS08405	COG1271	oxidase subunit
AC612_RS08410	COG1294	oxidase, subunit
AC612_RS08420	COG2239	Acts as a magnesium transporter
AC612_RS08430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC612_RS08435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC612_RS08445	COG1660	Displays ATPase and GTPase activities
AC612_RS08450	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AC612_RS08455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC612_RS08470	COG1137	ATPase activity
AC612_RS08475	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AC612_RS08485	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AC612_RS08495	COG0271	Belongs to the BolA IbaG family
AC612_RS08500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AC612_RS08520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AC612_RS08530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AC612_RS08540	COG0628	permease
AC612_RS08555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AC612_RS08560	COG3178	'Phosphotransferase
AC612_RS08575	COG1555	photosystem II stabilization
AC612_RS08585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC612_RS08590	COG1477	protein flavinylation
AC612_RS08615	COG3128	pkhd-type hydroxylase
AC612_RS08620	COG4774	siderophore transport
AC612_RS08625	COG2146	nitrite reductase [NAD(P)H] activity
AC612_RS08635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC612_RS08640	COG0719	Fe-S assembly protein
AC612_RS08645	COG0396	ATPase activity
AC612_RS08650	COG0719	Fe-S assembly protein
AC612_RS08655	COG1959	2 iron, 2 sulfur cluster binding
AC612_RS08665	COG0693	protein deglycase activity
AC612_RS08685	COG0739	heme binding
AC612_RS08700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AC612_RS08725	COG0519	Catalyzes the synthesis of GMP from XMP
AC612_RS08735	COG1678	Uncharacterized ACR, COG1678
AC612_RS08740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AC612_RS08745	COG0540	Belongs to the ATCase OTCase family
AC612_RS08750	COG1764	response to oxidative stress
AC612_RS08760	COG0384	phenazine biosynthesis protein PhzF
AC612_RS08765	COG0384	phenazine biosynthesis protein PhzF
AC612_RS08770	COG0527	aspartate kinase activity
AC612_RS08785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AC612_RS08800	COG0142	geranyltranstransferase activity
AC612_RS08805	COG0629	single-stranded DNA binding
AC612_RS08810	COG5001	Diguanylate cyclase
AC612_RS08810	COG4251	negative regulation of phosphorylation
AC612_RS08810	COG3706	GGDEF domain
AC612_RS08810	COG2203	Gaf domain
AC612_RS08815	COG3321	synthase
AC612_RS08815	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS08815	COG0604	alcohol dehydrogenase
AC612_RS08820	COG2080	2 iron, 2 sulfur cluster binding
AC612_RS08825	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC612_RS08830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC612_RS08835	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AC612_RS08885	COG2879	small protein
AC612_RS08890	COG1966	Carbon starvation protein
AC612_RS08895	COG1741	Belongs to the pirin family
AC612_RS08910	COG1741	Belongs to the pirin family
AC612_RS08915	COG3328	transposase activity
AC612_RS08925	COG1515	deoxyribonuclease V activity
AC612_RS08930	COG0588	phosphoglycerate mutase activity
AC612_RS08940	COG3590	peptidase
AC612_RS08945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC612_RS08950	COG2201	protein-glutamate methylesterase activity
AC612_RS08955	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AC612_RS08960	COG2202	Pas domain
AC612_RS08960	COG2199	diguanylate cyclase activity
AC612_RS08960	COG2200	EAL domain
AC612_RS08965	COG0835	chemotaxis
AC612_RS08970	COG0840	transmembrane signaling receptor activity
AC612_RS08975	COG2198	Histidine kinase
AC612_RS08975	COG0643	Histidine kinase
AC612_RS08985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AC612_RS08995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AC612_RS09000	COG0745	RESPONSE REGULATOR receiver
AC612_RS09005	COG2205	protein histidine kinase activity
AC612_RS09015	COG4452	Inner membrane protein CreD
AC612_RS09040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC612_RS09045	COG0735	belongs to the Fur family
AC612_RS09060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC612_RS09070	COG1309	transcriptional regulator
AC612_RS09080	COG2207	Transcriptional regulator
AC612_RS09090	COG0583	DNA-binding transcription factor activity
AC612_RS09095	COG2814	Major facilitator Superfamily
AC612_RS09100	COG0667	Aldo Keto reductase
AC612_RS09205	COG1595	DNA-templated transcription, initiation
AC612_RS09215	COG5002	protein histidine kinase activity
AC612_RS09215	COG5001	Diguanylate cyclase
AC612_RS09220	COG1187	pseudouridine synthase activity
AC612_RS09240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC612_RS09250	COG0475	glutathione-regulated potassium exporter activity
AC612_RS09255	COG5002	protein histidine kinase activity
AC612_RS09255	COG5000	phosphorelay sensor kinase activity
AC612_RS09260	COG0745	RESPONSE REGULATOR receiver
AC612_RS09265	COG1538	Outer membrane efflux protein
AC612_RS09290	COG1132	(ABC) transporter
AC612_RS09335	COG2155	Conserved Protein
AC612_RS09355	COG3328	transposase activity
AC612_RS09380	COG3118	belongs to the thioredoxin family
AC612_RS09390	COG0495	leucyl-tRNA aminoacylation
AC612_RS09405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AC612_RS09420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AC612_RS09435	COG2968	Membrane
AC612_RS09440	COG0424	maF-like protein
AC612_RS09450	COG3164	Protein of unknown function
AC612_RS09460	COG0312	modulator of DNA gyrase
AC612_RS09465	COG3028	Belongs to the UPF0307 family
AC612_RS09470	COG0312	modulator of DNA gyrase
AC612_RS09480	COG4104	PAAR repeat-containing protein
AC612_RS09485	COG0142	geranyltranstransferase activity
AC612_RS09490	COG1722	exodeoxyribonuclease VII activity
AC612_RS09495	COG0037	tRNA processing
AC612_RS09505	COG1785	Belongs to the alkaline phosphatase family
AC612_RS09510	COG1301	dicarboxylic acid transport
AC612_RS09515	COG4106	trans-aconitate 2-methyltransferase activity
AC612_RS09525	COG0791	NLP P60 protein
AC612_RS09530	COG0791	NLP P60 protein
AC612_RS09535	COG1047	Peptidyl-prolyl cis-trans
AC612_RS09540	COG2311	Membrane
AC612_RS09545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC612_RS09550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC612_RS09570	COG3590	peptidase
AC612_RS09575	COG3590	peptidase
AC612_RS09585	COG3039	Transposase
AC612_RS09600	COG0489	protein tyrosine kinase activity
AC612_RS09610	COG0717	Belongs to the dCTP deaminase family
AC612_RS09670	COG3328	transposase activity
AC612_RS09680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC612_RS09685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC612_RS09700	COG0494	nUDIX hydrolase
AC612_RS09705	COG0433	COG0433 Predicted ATPase
AC612_RS09720	COG0688	phosphatidylethanolamine metabolic process
AC612_RS09730	COG2890	protein-(glutamine-N5) methyltransferase activity
AC612_RS09735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AC612_RS09740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC612_RS09745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AC612_RS09760	COG0101	tRNA pseudouridine synthase activity
AC612_RS09765	COG0135	phosphoribosylanthranilate isomerase activity
AC612_RS09775	COG0133	tryptophan synthase activity
AC612_RS09785	COG0159	tryptophan synthase activity
AC612_RS09790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AC612_RS09795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC612_RS09825	COG0300	oxidoreductase activity
AC612_RS09830	COG0149	triose-phosphate isomerase activity
AC612_RS09845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC612_RS09850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC612_RS09855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC612_RS09860	COG0649	NAD binding
AC612_RS09865	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AC612_RS09870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AC612_RS09880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AC612_RS09885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC612_RS09910	COG1007	ATP synthesis coupled electron transport
AC612_RS09920	COG0779	Required for maturation of 30S ribosomal subunits
AC612_RS09925	COG0195	Participates in both transcription termination and antitermination
AC612_RS09930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AC612_RS09935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AC612_RS09940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AC612_RS09945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AC612_RS09950	COG1185	polyribonucleotide nucleotidyltransferase activity
AC612_RS09985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC612_RS09995	COG2095	MarC family integral membrane protein
AC612_RS10010	COG1611	Belongs to the LOG family
AC612_RS10070	COG3328	transposase activity
AC612_RS10085	COG3328	transposase activity
AC612_RS10095	COG0556	nucleotide-excision repair
AC612_RS10110	COG3505	Type IV secretory pathway VirD4
AC612_RS10130	COG2948	multi-organism process
AC612_RS10150	COG3702	type iv secretory pathway
AC612_RS10200	COG3328	transposase activity
AC612_RS10210	COG0326	Molecular chaperone. Has ATPase activity
AC612_RS10215	COG0742	ribosomal rna small subunit methyltransferase
AC612_RS10220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AC612_RS10235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AC612_RS10240	COG0405	Gamma-glutamyltransferase
AC612_RS10245	COG3291	Pkd domain containing protein
AC612_RS10250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AC612_RS10290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AC612_RS10295	COG0343	queuine tRNA-ribosyltransferase activity
AC612_RS10300	COG1862	Preprotein translocase
AC612_RS10310	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AC612_RS10335	COG3328	transposase activity
AC612_RS10350	COG3328	transposase activity
AC612_RS10365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC612_RS10365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC612_RS10370	COG1105	Belongs to the carbohydrate kinase PfkB family
AC612_RS10375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC612_RS10375	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC612_RS10380	COG1609	Transcriptional regulator
AC612_RS10385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC612_RS10390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC612_RS10400	COG2902	Dehydrogenase
AC612_RS10410	COG3321	synthase
AC612_RS10410	COG0604	alcohol dehydrogenase
AC612_RS10420	COG1902	pentaerythritol trinitrate reductase activity
AC612_RS10430	COG0300	oxidoreductase activity
AC612_RS10455	COG0477	Major facilitator Superfamily
AC612_RS10470	COG2205	protein histidine kinase activity
AC612_RS10470	COG5002	protein histidine kinase activity
AC612_RS10470	COG0784	Response regulator, receiver
AC612_RS10475	COG2733	membrane
AC612_RS10485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AC612_RS10500	COG2223	nitrite transmembrane transporter activity
AC612_RS10510	COG0243	molybdopterin cofactor binding
AC612_RS10525	COG0477	Major facilitator Superfamily
AC612_RS10530	COG2703	oxygen carrier activity
AC612_RS10540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC612_RS10545	COG0174	glutamine synthetase
AC612_RS10550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AC612_RS10570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AC612_RS10600	COG1176	ABC-type spermidine putrescine transport system, permease component I
AC612_RS10605	COG1177	transmembrane transport
AC612_RS10610	COG1012	belongs to the aldehyde dehydrogenase family
AC612_RS10625	COG4535	Mg2 and Co2 transporter CorC
AC612_RS10635	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AC612_RS10645	COG1702	phosphate starvation-inducible protein PhoH
AC612_RS10650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC612_RS10665	COG0741	lytic transglycosylase activity
AC612_RS10675	COG0723	plastoquinol--plastocyanin reductase activity
AC612_RS10680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AC612_RS10685	COG2857	Cytochrome c1
AC612_RS10690	COG0625	glutathione transferase activity
AC612_RS10695	COG2969	positive regulation of protein catabolic process
AC612_RS10715	COG1201	RNA secondary structure unwinding
AC612_RS10720	COG2094	Belongs to the DNA glycosylase MPG family
AC612_RS10725	COG0840	transmembrane signaling receptor activity
AC612_RS10730	COG0835	chemotaxis
AC612_RS10775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC612_RS10790	COG1570	exodeoxyribonuclease VII activity
AC612_RS10795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AC612_RS10800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC612_RS10800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AC612_RS10805	COG0802	atpase or kinase
AC612_RS10810	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC612_RS10815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AC612_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS10845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC612_RS10850	COG0501	Belongs to the peptidase M48B family
AC612_RS10855	COG3039	Transposase
AC612_RS10865	COG2081	HI0933 family
AC612_RS10870	COG4681	YaeQ
AC612_RS10880	COG0625	glutathione transferase activity
AC612_RS10890	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AC612_RS10895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AC612_RS10900	COG0513	Belongs to the DEAD box helicase family
AC612_RS10905	COG0488	(ABC) transporter
AC612_RS10925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AC612_RS10930	COG0483	inositol monophosphate 1-phosphatase activity
AC612_RS10945	COG5001	Diguanylate cyclase
AC612_RS10945	COG3300	MHYT domain
AC612_RS10950	COG1509	lysine 2,3-aminomutase activity
AC612_RS10955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC612_RS10965	COG0402	S-adenosylhomocysteine deaminase activity
AC612_RS10970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AC612_RS11035	COG4302	ethanolamine ammonia-lyase activity
AC612_RS11060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC612_RS11065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AC612_RS11080	COG2166	iron-sulfur cluster assembly
AC612_RS11085	COG0215	cysteine-tRNA ligase activity
AC612_RS11095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AC612_RS11100	COG0137	argininosuccinate synthase activity
AC612_RS11110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC612_RS11115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AC612_RS11125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AC612_RS11130	COG0165	Argininosuccinate lyase
AC612_RS11140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AC612_RS11145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AC612_RS11270	COG1294	oxidase, subunit
AC612_RS11280	COG4988	ABC transporter
AC612_RS11285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AC612_RS11290	COG1278	Cold shock
AC612_RS11295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC612_RS11315	COG1138	Cytochrome C-type biogenesis protein
AC612_RS11320	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC612_RS11340	COG4133	protoheme IX ABC transporter activity
AC612_RS11345	COG0436	Aminotransferase
AC612_RS11370	COG1187	pseudouridine synthase activity
AC612_RS11375	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AC612_RS11380	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AC612_RS11385	COG2350	Protein conserved in bacteria
AC612_RS11415	COG1175	transmembrane transport
AC612_RS11420	COG0395	ABC-type sugar transport system, permease component
AC612_RS11445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC612_RS11450	COG2957	Belongs to the agmatine deiminase family
AC612_RS11470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AC612_RS11475	COG0539	negative regulation of cytoplasmic translation
AC612_RS11480	COG0776	regulation of translation
AC612_RS11490	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AC612_RS11495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC612_RS11505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AC612_RS11515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC612_RS11515	COG0475	glutathione-regulated potassium exporter activity
AC612_RS11530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AC612_RS11540	COG0519	Catalyzes the synthesis of GMP from XMP
AC612_RS11540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC612_RS11550	COG3328	transposase activity
AC612_RS11580	COG2197	response regulator
AC612_RS11595	COG1335	isochorismatase
AC612_RS11610	COG2814	Major facilitator Superfamily
AC612_RS11625	COG1648	precorrin-2 dehydrogenase activity
AC612_RS11625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC612_RS11645	COG3685	Protein conserved in bacteria
AC612_RS11665	COG5001	Diguanylate cyclase
AC612_RS11675	COG4566	intracellular signal transduction
AC612_RS11715	COG3275	phosphorelay sensor kinase activity
AC612_RS11720	COG3279	Response regulator of the LytR AlgR family
AC612_RS11775	COG3920	Histidine kinase
AC612_RS11805	COG3220	belongs to the UPF0276 family
AC612_RS11845	COG3039	Transposase
AC612_RS11900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC612_RS11910	COG3321	synthase
AC612_RS11910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC612_RS11910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC612_RS11910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AC612_RS11910	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS11910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC612_RS11910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC612_RS11910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AC612_RS11910	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS11910	COG3321	synthase
AC612_RS11915	COG3321	synthase
AC612_RS11915	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS11915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AC612_RS11915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC612_RS11915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC612_RS11920	COG4221	oxidoreductase activity
AC612_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS11920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AC612_RS11920	COG3321	synthase
AC612_RS11925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AC612_RS11930	COG1136	(ABC) transporter
AC612_RS12110	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS12115	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AC612_RS12170	COG0316	Belongs to the HesB IscA family
AC612_RS12170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AC612_RS12175	COG2154	pterin-4-alpha-carbinolamine dehydratase
AC612_RS12185	COG0428	transporter
AC612_RS12190	COG3039	Transposase
AC612_RS12195	COG3064	Membrane
AC612_RS12205	COG1530	ribonuclease E activity
AC612_RS12215	COG1054	Belongs to the UPF0176 family
AC612_RS12235	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AC612_RS12260	COG3328	transposase activity
AC612_RS12285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AC612_RS12290	COG1061	Type III restriction enzyme res subunit
AC612_RS12300	COG3328	transposase activity
AC612_RS12370	COG0629	single-stranded DNA binding
AC612_RS12380	COG0270	DNA (cytosine-5-)-methyltransferase activity
AC612_RS12395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC612_RS12410	COG2951	lytic endotransglycosylase activity
AC612_RS12425	COG3039	Transposase
AC612_RS12430	COG3328	transposase activity
AC612_RS12640	COG0583	DNA-binding transcription factor activity
AC612_RS12645	COG0477	Major facilitator Superfamily
AC612_RS12660	COG1960	acyl-CoA dehydrogenase activity
AC612_RS12950	COG0583	DNA-binding transcription factor activity
AC612_RS12965	COG0582	viral genome integration into host DNA
AC612_RS12975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC612_RS12980	COG0322	excinuclease ABC activity
AC612_RS12990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC612_RS12995	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AC612_RS13000	COG1663	tetraacyldisaccharide 4'-kinase activity
AC612_RS13005	COG1132	(ABC) transporter
AC612_RS13010	COG0848	biopolymer transport protein
AC612_RS13015	COG0811	peptide transport
AC612_RS13030	COG1136	(ABC) transporter
AC612_RS13035	COG4591	ABC-type transport system involved in lipoprotein release permease component
AC612_RS13045	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AC612_RS13050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AC612_RS13065	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AC612_RS13080	COG0354	folic acid binding
AC612_RS13090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC612_RS13095	COG0837	glucose binding
AC612_RS13100	COG0363	glucosamine-6-phosphate deaminase activity
AC612_RS13105	COG0129	dihydroxy-acid dehydratase activity
AC612_RS13110	COG0800	Aldolase
AC612_RS13175	COG0784	Response regulator, receiver
AC612_RS13175	COG2205	protein histidine kinase activity
AC612_RS13185	COG2183	response to ionizing radiation
AC612_RS13195	COG0723	plastoquinol--plastocyanin reductase activity
AC612_RS13195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC612_RS13210	COG3243	poly(R)-hydroxyalkanoic acid synthase
AC612_RS13220	COG1183	phosphatidylcholine synthase activity
AC612_RS13225	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS13240	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AC612_RS13250	COG0668	transmembrane transport
AC612_RS13255	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AC612_RS13270	COG1914	H( )-stimulated, divalent metal cation uptake system
AC612_RS13300	COG0746	molybdenum cofactor guanylyltransferase activity
AC612_RS13305	COG0303	'Molybdopterin
AC612_RS13315	COG0708	Exodeoxyribonuclease III
AC612_RS13350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AC612_RS13355	COG0303	'Molybdopterin
AC612_RS13360	COG1160	GTP binding
AC612_RS13365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC612_RS13375	COG1426	Protein conserved in bacteria
AC612_RS13385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AC612_RS13400	COG1024	Enoyl-CoA hydratase
AC612_RS13400	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC612_RS13405	COG0183	Belongs to the thiolase family
AC612_RS13415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC612_RS13420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AC612_RS13430	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AC612_RS13440	COG1674	ftsk spoiiie
AC612_RS13445	COG0492	ferredoxin-NADP+ reductase activity
AC612_RS13455	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AC612_RS13465	COG0542	response to heat
AC612_RS13480	COG0482	sulfurtransferase activity
AC612_RS13485	COG2915	High frequency lysogenization protein hflD homolog
AC612_RS13515	COG5002	protein histidine kinase activity
AC612_RS13540	COG0835	chemotaxis
AC612_RS13540	COG0784	Response regulator, receiver
AC612_RS13550	COG1558	bacterial-type flagellum-dependent cell motility
AC612_RS13555	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AC612_RS13565	COG4787	bacterial-type flagellum-dependent cell motility
AC612_RS13575	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AC612_RS13580	COG1706	bacterial-type flagellum-dependent cell motility
AC612_RS13585	COG3951	Flagellar rod assembly protein muramidase FlgJ
AC612_RS13585	COG1705	Flagellar rod assembly protein muramidase FlgJ
AC612_RS13595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AC612_RS13600	COG3039	Transposase
AC612_RS13620	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AC612_RS13670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC612_RS13675	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS13680	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS13710	COG3039	Transposase
AC612_RS13720	COG0582	viral genome integration into host DNA
AC612_RS13730	COG3040	lipid binding
AC612_RS13740	COG1960	acyl-CoA dehydrogenase activity
AC612_RS13750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AC612_RS13770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC612_RS13775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC612_RS13780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC612_RS13805	COG0438	transferase activity, transferring glycosyl groups
AC612_RS13815	COG0438	transferase activity, transferring glycosyl groups
AC612_RS13820	COG0438	transferase activity, transferring glycosyl groups
AC612_RS13870	COG0072	phenylalanine-tRNA ligase activity
AC612_RS13870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC612_RS13875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AC612_RS13890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AC612_RS13895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AC612_RS13910	COG2190	(PTS) system
AC612_RS13910	COG2211	Major facilitator Superfamily
AC612_RS13945	COG3039	Transposase
AC612_RS13950	COG3039	Transposase
AC612_RS13985	COG0366	Alpha amylase catalytic
AC612_RS13990	COG3328	transposase activity
AC612_RS14110	COG0531	amino acid
AC612_RS14125	COG0006	proline dipeptidase activity
AC612_RS14135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC612_RS14150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC612_RS14155	COG3938	Belongs to the proline racemase family
AC612_RS14165	COG0552	protein localization to endoplasmic reticulum
AC612_RS14175	COG1194	a g-specific adenine glycosylase
AC612_RS14180	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AC612_RS14185	COG4191	Histidine kinase
AC612_RS14185	COG0784	Response regulator, receiver
AC612_RS14230	COG3039	Transposase
AC612_RS14260	COG3039	Transposase
AC612_RS14285	COG1677	Flagellar hook-basal body complex protein FliE
AC612_RS14335	COG3190	flagellar
AC612_RS14360	COG1684	flagellar biosynthetic protein fliR
AC612_RS14390	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC612_RS14420	COG2198	Histidine kinase
AC612_RS14420	COG0643	Histidine kinase
AC612_RS14420	COG0784	Response regulator, receiver
AC612_RS14450	COG3039	Transposase
AC612_RS14485	COG3328	transposase activity
AC612_RS14500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AC612_RS14505	COG1360	Flagellar Motor Protein
AC612_RS14515	COG0835	chemotaxis
AC612_RS14525	COG0745	RESPONSE REGULATOR receiver
AC612_RS14535	COG0840	transmembrane signaling receptor activity
AC612_RS14555	COG0840	transmembrane signaling receptor activity
AC612_RS14560	COG0840	transmembrane signaling receptor activity
AC612_RS14565	COG0840	transmembrane signaling receptor activity
AC612_RS14575	COG0840	transmembrane signaling receptor activity
AC612_RS14580	COG0840	transmembrane signaling receptor activity
AC612_RS14585	COG0840	transmembrane signaling receptor activity
AC612_RS14590	COG0840	transmembrane signaling receptor activity
AC612_RS14625	COG0835	chemotaxis
AC612_RS14640	COG0840	transmembrane signaling receptor activity
AC612_RS14650	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AC612_RS14655	COG2201	protein-glutamate methylesterase activity
AC612_RS14665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC612_RS14695	COG0318	PFAM AMP-dependent synthetase and ligase
AC612_RS14700	COG1024	Enoyl-CoA hydratase
AC612_RS14705	COG0784	Response regulator, receiver
AC612_RS14705	COG2198	Histidine kinase
AC612_RS14705	COG2205	protein histidine kinase activity
AC612_RS14710	COG0784	Response regulator, receiver
AC612_RS14710	COG2198	Histidine kinase
AC612_RS14710	COG2205	protein histidine kinase activity
AC612_RS14720	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AC612_RS14730	COG3279	Response regulator of the LytR AlgR family
AC612_RS14740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AC612_RS14750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC612_RS14755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AC612_RS14765	COG0505	Belongs to the CarA family
AC612_RS14770	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AC612_RS14775	COG2258	MOSC domain
AC612_RS14780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC612_RS14825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC612_RS14845	COG0277	FAD linked oxidase domain protein
AC612_RS14850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AC612_RS14860	COG0531	amino acid
AC612_RS14865	COG0531	amino acid
AC612_RS14870	COG0235	Class ii aldolase
AC612_RS14875	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AC612_RS14880	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AC612_RS14895	COG0140	phosphoribosyl-ATP diphosphatase activity
AC612_RS14895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AC612_RS14900	COG0107	imidazoleglycerol-phosphate synthase activity
AC612_RS14905	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AC612_RS14910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AC612_RS14915	COG0131	Imidazoleglycerol-phosphate dehydratase
AC612_RS14915	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AC612_RS14920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC612_RS14925	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AC612_RS14930	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AC612_RS14940	COG0124	histidyl-tRNA synthetase
AC612_RS14945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC612_RS14985	COG3328	transposase activity
AC612_RS15015	COG3328	transposase activity
AC612_RS15070	COG3328	transposase activity
AC612_RS15095	COG1649	PFAM Uncharacterised BCR, COG1649
AC612_RS15095	COG0726	polysaccharide deacetylase
AC612_RS15100	COG1215	transferase activity, transferring glycosyl groups
AC612_RS15115	COG1012	belongs to the aldehyde dehydrogenase family
AC612_RS15130	COG0167	dihydroorotate dehydrogenase activity
AC612_RS15135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AC612_RS15140	COG0697	spore germination
AC612_RS15150	COG1794	racemase activity, acting on amino acids and derivatives
AC612_RS15170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AC612_RS15180	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AC612_RS15195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC612_RS15205	COG5001	Diguanylate cyclase
AC612_RS15205	COG4251	negative regulation of phosphorylation
AC612_RS15205	COG3706	GGDEF domain
AC612_RS15205	COG2203	Gaf domain
AC612_RS15220	COG1472	Belongs to the glycosyl hydrolase 3 family
AC612_RS15245	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AC612_RS15250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AC612_RS15255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AC612_RS15275	COG1469	GTP cyclohydrolase I activity
AC612_RS15280	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC612_RS15290	COG3039	Transposase
AC612_RS15315	COG3328	transposase activity
AC612_RS15335	COG3328	transposase activity
AC612_RS15345	COG1070	Carbohydrate kinase
AC612_RS15355	COG1501	Belongs to the glycosyl hydrolase 31 family
AC612_RS15395	COG0800	Aldolase
AC612_RS15400	COG4948	Mandelate Racemase Muconate Lactonizing
AC612_RS15410	COG3734	2-keto-3-deoxy-galactonokinase
AC612_RS15415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AC612_RS15425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC612_RS15440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AC612_RS15445	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AC612_RS15460	COG0351	phosphomethylpyrimidine kinase
AC612_RS15485	COG0583	DNA-binding transcription factor activity
AC612_RS15490	COG1741	Belongs to the pirin family
AC612_RS15510	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AC612_RS15515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AC612_RS15520	COG2137	regulation of response to DNA damage stimulus
AC612_RS15530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AC612_RS15535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC612_RS15545	COG1546	Belongs to the CinA family
AC612_RS15550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AC612_RS15560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AC612_RS15565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AC612_RS15575	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AC612_RS15580	COG1534	Rna-binding protein
AC612_RS15595	COG1238	metal cluster binding
AC612_RS15600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC612_RS15605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AC612_RS15610	COG2840	Smr protein MutS2
AC612_RS15615	COG0585	pseudouridine synthase activity
AC612_RS15620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AC612_RS15625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AC612_RS15630	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AC612_RS15635	COG0148	phosphopyruvate hydratase activity
AC612_RS15650	COG0504	CTP synthase activity
AC612_RS15680	COG0306	phosphate transporter
AC612_RS15695	COG1253	flavin adenine dinucleotide binding
AC612_RS15705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC612_RS15715	COG0477	Major facilitator Superfamily
AC612_RS15725	COG1136	(ABC) transporter
AC612_RS15750	COG2264	protein methyltransferase activity
AC612_RS15780	COG2244	polysaccharide biosynthetic process
AC612_RS15835	COG1595	DNA-templated transcription, initiation
AC612_RS15850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC612_RS15860	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC612_RS15870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC612_RS15885	COG4191	Histidine kinase
AC612_RS15885	COG0784	Response regulator, receiver
AC612_RS15890	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AC612_RS15925	COG0840	transmembrane signaling receptor activity
AC612_RS15950	COG3328	transposase activity
AC612_RS15970	COG0583	DNA-binding transcription factor activity
AC612_RS15975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AC612_RS15980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AC612_RS16000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AC612_RS16005	COG0077	Prephenate dehydratase
AC612_RS16005	COG1605	Chorismate mutase
AC612_RS16010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AC612_RS16015	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AC612_RS16020	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AC612_RS16060	COG1228	amidohydrolase
AC612_RS16065	COG2986	histidine ammonia-lyase
AC612_RS16075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AC612_RS16090	COG4993	Dehydrogenase
AC612_RS16100	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AC612_RS16115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AC612_RS16120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AC612_RS16125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC612_RS16135	COG3115	cell septum assembly
AC612_RS16150	COG0359	binds to the 23S rRNA
AC612_RS16155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AC612_RS16160	COG0360	Binds together with S18 to 16S ribosomal RNA
AC612_RS16165	COG0316	Belongs to the HesB IscA family
AC612_RS16175	COG0017	Asparaginyl-tRNA synthetase
AC612_RS16210	COG3039	Transposase
AC612_RS16260	COG0288	reversible hydration of carbon dioxide
AC612_RS16265	COG0662	Cupin 2, conserved barrel domain protein
AC612_RS16275	COG3844	kynureninase activity
AC612_RS16280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC612_RS16285	COG2925	Exonuclease
AC612_RS16310	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AC612_RS16315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC612_RS16315	COG0116	Belongs to the methyltransferase superfamily
AC612_RS16325	COG0488	(ABC) transporter
AC612_RS16360	COG0494	nUDIX hydrolase
AC612_RS16370	COG1024	Enoyl-CoA hydratase
AC612_RS16380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AC612_RS16385	COG0659	secondary active sulfate transmembrane transporter activity
AC612_RS16410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AC612_RS16415	COG0573	inorganic phosphate transmembrane transporter activity
AC612_RS16420	COG0581	inorganic phosphate transmembrane transporter activity
AC612_RS16425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AC612_RS16430	COG0704	Plays a role in the regulation of phosphate uptake
AC612_RS16440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC612_RS16450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC612_RS16460	COG0557	exoribonuclease II activity
AC612_RS16480	COG1960	acyl-CoA dehydrogenase activity
AC612_RS16490	COG1960	acyl-CoA dehydrogenase activity
AC612_RS16495	COG2226	methyltransferase
AC612_RS16500	COG1410	methionine synthase
AC612_RS16500	COG0646	methionine synthase
AC612_RS16505	COG1410	methionine synthase
AC612_RS16505	COG0646	methionine synthase
AC612_RS16515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC612_RS16540	COG2900	Belongs to the SlyX family
AC612_RS16555	COG0386	Belongs to the glutathione peroxidase family
AC612_RS16565	COG1725	Transcriptional regulator
AC612_RS16570	COG1131	(ABC) transporter
AC612_RS16605	COG1253	flavin adenine dinucleotide binding
AC612_RS16625	COG2850	peptidyl-arginine hydroxylation
AC612_RS16635	COG0567	Dehydrogenase, E1 component
AC612_RS16660	COG1132	(ABC) transporter
AC612_RS16665	COG0583	DNA-binding transcription factor activity
AC612_RS16695	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AC612_RS16705	COG0484	heat shock protein binding
AC612_RS16710	COG0443	Heat shock 70 kDa protein
AC612_RS16715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AC612_RS16720	COG1420	regulation of RNA biosynthetic process
AC612_RS16725	COG0497	DNA recombination
AC612_RS16735	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC612_RS16750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AC612_RS16765	COG0582	viral genome integration into host DNA
AC612_RS16770	COG3328	transposase activity
AC612_RS16795	COG3328	transposase activity
AC612_RS16810	COG3706	GGDEF domain
AC612_RS16855	COG0583	DNA-binding transcription factor activity
AC612_RS16865	COG0415	Belongs to the DNA photolyase family
AC612_RS16870	COG0305	Participates in initiation and elongation during chromosome replication
AC612_RS16880	COG0367	asparagine synthase
AC612_RS16900	COG1960	acyl-CoA dehydrogenase activity
AC612_RS16915	COG0084	hydrolase, TatD family'
AC612_RS16920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AC612_RS16975	COG0386	Belongs to the glutathione peroxidase family
AC612_RS16985	COG0339	signal peptide processing
AC612_RS17040	COG2814	Major facilitator Superfamily
AC612_RS17045	COG1566	PFAM secretion protein HlyD family protein
AC612_RS17070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC612_RS17085	COG4774	siderophore transport
AC612_RS17095	COG0367	asparagine synthase
AC612_RS17100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC612_RS17105	COG1393	Belongs to the ArsC family
AC612_RS17115	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AC612_RS17155	COG0052	Belongs to the universal ribosomal protein uS2 family
AC612_RS17160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AC612_RS17170	COG0528	UMP kinase activity
AC612_RS17175	COG0233	cytoplasmic translational termination
AC612_RS17180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AC612_RS17185	COG0575	Belongs to the CDS family
AC612_RS17190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AC612_RS17195	COG0750	zinc metalloprotease
AC612_RS17210	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC612_RS17215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC612_RS17220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC612_RS17225	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC612_RS17240	COG0825	malonyl-CoA metabolic process
AC612_RS17255	COG1981	membrane
AC612_RS17275	COG1695	Transcriptional regulator
AC612_RS17300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AC612_RS17310	COG2040	homocysteine
AC612_RS17315	COG0833	amino acid
AC612_RS17320	COG0346	lactoylglutathione lyase activity
AC612_RS17325	COG1131	(ABC) transporter
AC612_RS17335	COG3039	Transposase
AC612_RS17350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC612_RS17350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC612_RS17365	COG2878	Part of a membrane complex involved in electron transport
AC612_RS17390	COG1595	DNA-templated transcription, initiation
AC612_RS17415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC612_RS17430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC612_RS17435	COG0251	oxidation-reduction process
AC612_RS17445	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AC612_RS17445	COG0392	lysyltransferase activity
AC612_RS17480	COG2814	Major facilitator Superfamily
AC612_RS17485	COG1902	pentaerythritol trinitrate reductase activity
AC612_RS17495	COG2824	Alkylphosphonate utilization operon protein PhnA
AC612_RS17505	COG1047	Peptidyl-prolyl cis-trans
AC612_RS17510	COG1077	Cell shape determining protein MreB Mrl
AC612_RS17525	COG3328	transposase activity
AC612_RS17530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AC612_RS17540	COG5487	UPF0391 membrane protein
AC612_RS17545	COG1451	nucleotide metabolic process
AC612_RS17570	COG0183	Belongs to the thiolase family
AC612_RS17605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AC612_RS17605	COG1793	dna ligase
AC612_RS17615	COG1793	dna ligase
AC612_RS17620	COG1201	RNA secondary structure unwinding
AC612_RS17630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC612_RS17635	COG1278	Cold shock
AC612_RS17640	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AC612_RS17645	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AC612_RS17650	COG1472	Belongs to the glycosyl hydrolase 3 family
AC612_RS17655	COG3046	protein related to deoxyribodipyrimidine photolyase
AC612_RS17660	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AC612_RS17665	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AC612_RS17670	COG2954	triphosphatase activity
AC612_RS17675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC612_RS17685	COG1381	Involved in DNA repair and RecF pathway recombination
AC612_RS17690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AC612_RS17695	COG0571	ribonuclease III activity
AC612_RS17710	COG0481	GTPase activity
AC612_RS17715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC612_RS17730	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC612_RS17730	COG1024	Enoyl-CoA hydratase
AC612_RS17735	COG2801	Transposase and inactivated derivatives
AC612_RS17740	COG3039	Transposase
AC612_RS17755	COG0745	RESPONSE REGULATOR receiver
AC612_RS17765	COG0189	ligase activity
AC612_RS17780	COG3039	Transposase
AC612_RS17815	COG3328	transposase activity
AC612_RS17835	COG3039	Transposase
AC612_RS17845	COG3039	Transposase
AC612_RS17870	COG3039	Transposase
AC612_RS17885	COG2003	Belongs to the UPF0758 family
AC612_RS17895	COG3328	transposase activity
AC612_RS17905	COG3328	transposase activity
AC612_RS17970	COG3328	transposase activity
AC612_RS17980	COG3328	transposase activity
AC612_RS18020	COG3328	transposase activity
AC612_RS18030	COG3328	transposase activity
AC612_RS18045	COG3328	transposase activity
AC612_RS18075	COG1752	Esterase of the alpha-beta hydrolase superfamily
AC612_RS18100	COG2022	thiamine diphosphate biosynthetic process
AC612_RS18105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AC612_RS18110	COG0471	metal ion transport
AC612_RS18110	COG3273	potassium ion transport
AC612_RS18135	COG1970	mechanosensitive ion channel activity
AC612_RS18145	COG1609	Transcriptional regulator
AC612_RS18155	COG3250	beta-galactosidase activity
AC612_RS18160	COG4948	Mandelate Racemase Muconate Lactonizing
AC612_RS18170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC612_RS18180	COG0308	aminopeptidase N
AC612_RS18185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC612_RS18195	COG3039	Transposase
AC612_RS18200	COG0529	Catalyzes the synthesis of activated sulfate
AC612_RS18200	COG2895	sulfate adenylyltransferase (ATP) activity
AC612_RS18205	COG0175	sulfate reduction
AC612_RS18210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC612_RS18215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC612_RS18220	COG0175	sulfate reduction
AC612_RS18225	COG3039	Transposase
AC612_RS18245	COG2205	protein histidine kinase activity
AC612_RS18245	COG2198	Histidine kinase
AC612_RS18245	COG0784	Response regulator, receiver
AC612_RS18265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC612_RS18265	COG1648	precorrin-2 dehydrogenase activity
AC612_RS18280	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AC612_RS18285	COG3588	fructose-bisphosphate aldolase
AC612_RS18300	COG0469	pyruvate kinase activity
AC612_RS18310	COG0126	phosphoglycerate kinase activity
AC612_RS18335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AC612_RS18345	COG3047	cAMP biosynthetic process
AC612_RS18350	COG3047	cAMP biosynthetic process
AC612_RS18360	COG3453	Protein conserved in bacteria
AC612_RS18360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC612_RS18365	COG0725	ABC transporter, periplasmic molybdate-binding protein
AC612_RS18370	COG4149	molybdate abc transporter
AC612_RS18410	COG1376	ErfK ybiS ycfS ynhG family protein
AC612_RS18415	COG0739	heme binding
AC612_RS18420	COG4773	Receptor
AC612_RS18430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AC612_RS18435	COG1301	dicarboxylic acid transport
AC612_RS18450	COG2304	oxidoreductase activity
AC612_RS18470	COG0714	Associated with various cellular activities
AC612_RS18505	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AC612_RS18530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AC612_RS18540	COG2721	sulfolactate sulfo-lyase activity
AC612_RS18555	COG2271	Major facilitator Superfamily
AC612_RS18570	COG0583	DNA-binding transcription factor activity
AC612_RS18575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC612_RS18590	COG1561	YicC-like family, N-terminal region
AC612_RS18595	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AC612_RS18605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AC612_RS18610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AC612_RS18625	COG0006	proline dipeptidase activity
AC612_RS18635	COG0006	proline dipeptidase activity
AC612_RS18640	COG3079	Belongs to the UPF0149 family
AC612_RS18660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AC612_RS18670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AC612_RS18680	COG2912	Transglutaminase-like superfamily
AC612_RS18690	COG1773	rubredoxin
AC612_RS18695	COG0352	thiamine-phosphate diphosphorylase activity
AC612_RS18710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC612_RS18725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC612_RS18760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC612_RS18765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC612_RS18770	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS18780	COG0671	phosphoesterase, PA-phosphatase related
AC612_RS18785	COG3781	membrane
AC612_RS18795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC612_RS18800	COG0563	adenylate kinase activity
AC612_RS18815	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AC612_RS18825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AC612_RS18840	COG3328	transposase activity
AC612_RS18855	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AC612_RS18870	COG0840	transmembrane signaling receptor activity
AC612_RS18875	COG0405	Gamma-glutamyltransferase
AC612_RS18880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AC612_RS18900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC612_RS18905	COG0473	3-isopropylmalate dehydrogenase activity
AC612_RS18910	COG0066	3-isopropylmalate dehydratase activity
AC612_RS18920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AC612_RS18940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC612_RS18945	COG1538	Outer membrane efflux protein
AC612_RS18950	COG1519	Transferase
AC612_RS18955	COG1560	Kdo2-lipid A biosynthetic process
AC612_RS18980	COG0281	malic enzyme
AC612_RS18980	COG0280	phosphate acetyltransferase
AC612_RS18985	COG1301	dicarboxylic acid transport
AC612_RS19010	COG0583	DNA-binding transcription factor activity
AC612_RS19015	COG0667	Aldo Keto reductase
AC612_RS19030	COG2197	response regulator
AC612_RS19040	COG0642	Histidine kinase
AC612_RS19060	COG2851	Citrate transporter
AC612_RS19065	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS19070	COG1609	Transcriptional regulator
AC612_RS19080	COG2211	Major facilitator Superfamily
AC612_RS19110	COG1162	GTPase activity
AC612_RS19115	COG0436	Aminotransferase
AC612_RS19130	COG0726	polysaccharide deacetylase
AC612_RS19135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC612_RS19150	COG3964	amidohydrolase
AC612_RS19155	COG0402	S-adenosylhomocysteine deaminase activity
AC612_RS19175	COG3039	Transposase
AC612_RS19180	COG1307	EDD domain protein, DegV family
AC612_RS19185	COG0242	peptide deformylase activity
AC612_RS19210	COG0457	Tetratricopeptide repeat
AC612_RS19215	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AC612_RS19220	COG1215	transferase activity, transferring glycosyl groups
AC612_RS19225	COG1215	transferase activity, transferring glycosyl groups
AC612_RS19240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AC612_RS19295	COG2188	Transcriptional regulator
AC612_RS19310	COG1450	Type ii and iii secretion system protein
AC612_RS19325	COG3166	PFAM Fimbrial assembly family protein
AC612_RS19330	COG3156	type II secretion system protein K
AC612_RS19335	COG4795	General secretion pathway protein
AC612_RS19340	COG2165	general secretion pathway protein
AC612_RS19345	COG4970	Tfp pilus assembly protein FimT
AC612_RS19350	COG2165	general secretion pathway protein
AC612_RS19355	COG1459	type II secretion system
AC612_RS19365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC612_RS19370	COG1404	Belongs to the peptidase S8 family
AC612_RS19380	COG1404	Belongs to the peptidase S8 family
AC612_RS19385	COG5295	Hep Hag repeat protein
AC612_RS19390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AC612_RS19390	COG0047	phosphoribosylformylglycinamidine synthase activity
AC612_RS19400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC612_RS19415	COG4974	Belongs to the 'phage' integrase family
AC612_RS19430	COG0795	lipopolysaccharide-transporting ATPase activity
AC612_RS19440	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC612_RS19455	COG0525	valine-tRNA ligase activity
AC612_RS19480	COG3328	transposase activity
AC612_RS19500	COG1183	phosphatidylcholine synthase activity
AC612_RS19510	COG0442	prolyl-tRNA aminoacylation
AC612_RS19525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC612_RS19530	COG1127	ABC transporter
AC612_RS19535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC612_RS19535	COG3218	ABC-type transport auxiliary lipoprotein component
AC612_RS19565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC612_RS19570	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AC612_RS19570	COG0662	Cupin 2, conserved barrel domain protein
AC612_RS19600	COG2086	electron transfer activity
AC612_RS19615	COG0463	Glycosyl transferase, family 2
AC612_RS19650	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AC612_RS19655	COG0438	transferase activity, transferring glycosyl groups
AC612_RS19675	COG0438	transferase activity, transferring glycosyl groups
AC612_RS19685	COG0626	cystathionine gamma-synthase activity
AC612_RS19715	COG0625	glutathione transferase activity
AC612_RS19730	COG0513	Belongs to the DEAD box helicase family
AC612_RS19740	COG4771	TonB-dependent receptor
AC612_RS19750	COG0720	synthase
AC612_RS19780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AC612_RS19785	COG1956	GAF domain-containing protein
AC612_RS19795	COG2819	hydrolase of the alpha beta superfamily
AC612_RS19805	COG0546	phosphoglycolate phosphatase activity
AC612_RS19810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AC612_RS19815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC612_RS19830	COG0339	signal peptide processing
AC612_RS19880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AC612_RS19885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC612_RS19890	COG1136	(ABC) transporter
AC612_RS19895	COG0577	efflux transmembrane transporter activity
AC612_RS19900	COG0577	efflux transmembrane transporter activity
AC612_RS19900	COG1136	(ABC) transporter
AC612_RS19915	COG4191	Histidine kinase
AC612_RS19920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AC612_RS19935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AC612_RS19940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AC612_RS19945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AC612_RS19950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AC612_RS19955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AC612_RS19960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AC612_RS19970	COG0356	it plays a direct role in the translocation of protons across the membrane
AC612_RS19990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC612_RS20000	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC612_RS20040	COG2011	ABC-type metal ion transport system permease component
AC612_RS20045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AC612_RS20050	COG0697	spore germination
AC612_RS20055	COG1666	GTP binding
AC612_RS20065	COG0784	Response regulator, receiver
AC612_RS20065	COG5002	protein histidine kinase activity
AC612_RS20065	COG2198	Histidine kinase
AC612_RS20095	COG1187	pseudouridine synthase activity
AC612_RS20100	COG2813	Specifically methylates the guanine in position
AC612_RS20120	COG2205	protein histidine kinase activity
AC612_RS20120	COG2202	Pas domain
AC612_RS20140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AC612_RS20145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC612_RS20210	COG1131	(ABC) transporter
AC612_RS20215	COG0025	NhaP-type Na H and K H
AC612_RS20225	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AC612_RS20230	COG1573	uracil-dna glycosylase
AC612_RS20240	COG3384	dioxygenase
AC612_RS20250	COG0583	DNA-binding transcription factor activity
AC612_RS20260	COG0667	Aldo Keto reductase
AC612_RS20275	COG3590	peptidase
AC612_RS20290	COG0531	amino acid
AC612_RS20305	COG2972	Histidine kinase
AC612_RS20330	COG3685	Protein conserved in bacteria
AC612_RS20335	COG3546	catalase activity
AC612_RS20370	COG2204	response regulator
AC612_RS20385	COG1271	oxidase subunit
AC612_RS20390	COG1294	oxidase, subunit
AC612_RS20405	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS20410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AC612_RS20430	COG1132	(ABC) transporter
AC612_RS20445	COG1063	alcohol dehydrogenase
AC612_RS20520	COG0251	oxidation-reduction process
AC612_RS20550	COG0583	DNA-binding transcription factor activity
AC612_RS20555	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AC612_RS20585	COG0659	secondary active sulfate transmembrane transporter activity
AC612_RS20595	COG0024	Methionine aminopeptidase
AC612_RS20640	COG3039	Transposase
AC612_RS20655	COG3039	Transposase
AC612_RS20665	COG3328	transposase activity
AC612_RS20680	COG3328	transposase activity
AC612_RS20700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC612_RS20705	COG1490	D-aminoacyl-tRNA deacylase activity
AC612_RS20710	COG1560	Kdo2-lipid A biosynthetic process
AC612_RS20765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC612_RS20765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AC612_RS20770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AC612_RS20775	COG0242	peptide deformylase activity
AC612_RS20780	COG1652	LysM domain
AC612_RS20785	COG0758	DNA mediated transformation
AC612_RS20805	COG1754	DNA topoisomerase type I activity
AC612_RS20805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AC612_RS20810	COG0009	L-threonylcarbamoyladenylate synthase
AC612_RS20825	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS20840	COG0616	signal peptide processing
AC612_RS20845	COG0534	Mate efflux family protein
AC612_RS20865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AC612_RS20870	COG0625	glutathione transferase activity
AC612_RS20885	COG1252	NADH dehydrogenase
AC612_RS20895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC612_RS20900	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AC612_RS20905	COG3437	response regulator, receiver
AC612_RS20910	COG2177	Part of the ABC transporter FtsEX involved in
AC612_RS20915	COG2884	Cell division ATP-binding protein ftsE
AC612_RS20920	COG0513	Belongs to the DEAD box helicase family
AC612_RS20925	COG3118	belongs to the thioredoxin family
AC612_RS20930	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AC612_RS20935	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AC612_RS20940	COG0583	DNA-binding transcription factor activity
AC612_RS20960	COG1652	LysM domain
AC612_RS20965	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC612_RS20965	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC612_RS20970	COG1473	amidohydrolase
AC612_RS20975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC612_RS20980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC612_RS21000	COG5383	Protein conserved in bacteria
AC612_RS21040	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AC612_RS21045	COG3023	N-Acetylmuramoyl-L-alanine amidase
AC612_RS21055	COG4948	Mandelate Racemase Muconate Lactonizing
AC612_RS21065	COG0531	amino acid
AC612_RS21100	COG3328	transposase activity
AC612_RS21110	COG2133	pyrroloquinoline quinone binding
AC612_RS21120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AC612_RS21125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AC612_RS21135	COG1610	YqeY-like protein
AC612_RS21145	COG1295	ribonuclease BN
AC612_RS21150	COG0358	DNA primase activity
AC612_RS21165	COG0109	protoheme IX farnesyltransferase activity
AC612_RS21195	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AC612_RS21210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AC612_RS21255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AC612_RS21260	COG0739	heme binding
AC612_RS21265	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AC612_RS21275	COG2211	Major facilitator Superfamily
AC612_RS21285	COG0708	Exodeoxyribonuclease III
AC612_RS21290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AC612_RS21300	COG1192	Involved in chromosome partitioning
AC612_RS21305	COG1475	DNA binding
AC612_RS21325	COG0463	Glycosyl transferase, family 2
AC612_RS21345	COG0756	dUTP diphosphatase activity
AC612_RS21350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AC612_RS21355	COG2003	Belongs to the UPF0758 family
AC612_RS21360	COG0018	arginyl-trna synthetase
AC612_RS21375	COG4221	oxidoreductase activity
AC612_RS21380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AC612_RS21380	COG2755	lipolytic protein G-D-S-L family
AC612_RS21400	COG1166	arginine decarboxylase activity
AC612_RS21405	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AC612_RS21430	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AC612_RS21430	COG3291	Pkd domain containing protein
AC612_RS21450	COG0606	chelatase, subunit chli
AC612_RS21465	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AC612_RS21495	COG3039	Transposase
AC612_RS21505	COG1690	Belongs to the RtcB family
AC612_RS21540	COG1090	epimerase
AC612_RS21550	COG0642	Histidine kinase
AC612_RS21575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC612_RS21600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AC612_RS21605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC612_RS21615	COG3328	transposase activity
AC612_RS21625	COG0753	catalase activity
AC612_RS21640	COG2197	response regulator
AC612_RS21645	COG4585	Histidine kinase
AC612_RS21650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC612_RS21655	COG1136	(ABC) transporter
AC612_RS21680	COG0697	spore germination
AC612_RS21700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC612_RS21705	COG0180	Tryptophanyl-tRNA synthetase
AC612_RS21710	COG3328	transposase activity
AC612_RS21715	COG3237	CsbD-like
AC612_RS21755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC612_RS21775	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AC612_RS21825	COG3039	Transposase
AC612_RS21830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AC612_RS21860	COG1199	ATP-dependent helicase activity
AC612_RS21875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC612_RS21945	COG0625	glutathione transferase activity
AC612_RS21980	COG4555	ABC transporter
AC612_RS21990	COG1476	TRANSCRIPTIONal
AC612_RS22010	COG1230	cation diffusion facilitator family transporter
AC612_RS22020	COG4774	siderophore transport
AC612_RS22035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC612_RS22040	COG1131	(ABC) transporter
AC612_RS22045	COG0842	Transport permease protein
AC612_RS22050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AC612_RS22080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC612_RS22090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC612_RS22100	COG1042	CoA-binding domain protein
AC612_RS22100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AC612_RS22100	COG0045	succinate-CoA ligase (ADP-forming) activity
AC612_RS22105	COG2239	Acts as a magnesium transporter
AC612_RS22125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC612_RS22130	COG3387	PFAM Glycoside hydrolase 15-related
AC612_RS22145	COG3100	YcgL domain-containing protein
AC612_RS22150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AC612_RS22160	COG0463	Glycosyl transferase, family 2
AC612_RS22170	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS22205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC612_RS22220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC612_RS22250	COG4946	Tricorn protease homolog
AC612_RS22250	COG1506	peptidase
AC612_RS22250	COG0823	Involved in the tonB-independent uptake of proteins
AC612_RS22255	COG3039	Transposase
AC612_RS22275	COG0408	coproporphyrinogen oxidase activity
AC612_RS22315	COG0515	serine threonine protein kinase
AC612_RS22380	COG1595	DNA-templated transcription, initiation
AC612_RS22500	COG0210	DNA helicase
AC612_RS22510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC612_RS22515	COG0583	DNA-binding transcription factor activity
AC612_RS22520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC612_RS22560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC612_RS22580	COG0357	Ribosomal RNA small subunit methyltransferase G
AC612_RS22585	COG3540	Alkaline phosphatase
AC612_RS22595	COG2091	lysine biosynthetic process via aminoadipic acid
AC612_RS22610	COG0708	Exodeoxyribonuclease III
AC612_RS22615	COG1940	carbohydrate kinase activity
AC612_RS22615	COG1846	Transcriptional regulator
AC612_RS22625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC612_RS22640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC612_RS22645	COG3162	membrane
AC612_RS22655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC612_RS22705	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS22710	COG0179	Fumarylacetoacetate (FAA) hydrolase
AC612_RS22715	COG4948	Mandelate Racemase Muconate Lactonizing
AC612_RS22720	COG3254	rhamnose metabolic process
AC612_RS22725	COG0738	Major facilitator superfamily
AC612_RS22730	COG1414	Transcriptional regulator
AC612_RS22735	COG1971	Probably functions as a manganese efflux pump
AC612_RS22740	COG2205	protein histidine kinase activity
AC612_RS22755	COG3459	Glycosyltransferase 36 associated
AC612_RS22760	COG2211	Major facilitator Superfamily
AC612_RS22765	COG3265	gluconokinase activity
AC612_RS22775	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC612_RS22800	COG2911	Protein conserved in bacteria
AC612_RS22805	COG0729	surface antigen
AC612_RS22815	COG3039	Transposase
AC612_RS22820	COG3039	Transposase
AC612_RS22825	COG3039	Transposase
AC612_RS22865	COG0752	glycyl-tRNA synthetase alpha subunit
AC612_RS22870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC612_RS22885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC612_RS22885	COG0519	Catalyzes the synthesis of GMP from XMP
AC612_RS22895	COG0805	protein transport
AC612_RS22900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC612_RS22905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC612_RS22915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AC612_RS22935	COG2974	May be involved in recombination
AC612_RS22940	COG0037	tRNA processing
AC612_RS22950	COG2115	Belongs to the xylose isomerase family
AC612_RS22960	COG3661	Belongs to the glycosyl hydrolase 67 family
AC612_RS22970	COG4948	Mandelate Racemase Muconate Lactonizing
AC612_RS22980	COG1472	Belongs to the glycosyl hydrolase 3 family
AC612_RS22985	COG0246	Mannitol dehydrogenase
AC612_RS23065	COG3039	Transposase
AC612_RS23070	COG3386	PFAM SMP-30 Gluconolaconase
AC612_RS23080	COG3250	beta-galactosidase activity
AC612_RS23085	COG1904	glucuronate isomerase
AC612_RS23100	COG3693	PFAM glycoside hydrolase, family 10
AC612_RS23115	COG2211	Major facilitator Superfamily
AC612_RS23150	COG1028	Short-chain dehydrogenase reductase Sdr
AC612_RS23150	COG3321	synthase
AC612_RS23150	COG0604	alcohol dehydrogenase
AC612_RS23155	COG2937	Belongs to the GPAT DAPAT family
AC612_RS23190	COG0284	orotidine-5'-phosphate decarboxylase activity
AC612_RS23195	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AC612_RS23205	COG3132	Protein of unknown function, DUF480
AC612_RS23230	COG0210	DNA helicase
AC612_RS23235	COG1435	thymidine kinase activity
AC612_RS23245	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AC612_RS23255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC612_RS23285	COG3135	benzoate transporter
AC612_RS23310	COG0676	glucose-6-phosphate 1-epimerase activity
AC612_RS23320	COG3012	SEC-C Motif Domain Protein
AC612_RS23325	COG0730	response to heat
AC612_RS23335	COG3328	transposase activity
AC612_RS23355	COG0302	gtp cyclohydrolase
AC612_RS23370	COG1566	PFAM secretion protein HlyD family protein
AC612_RS23380	COG1289	transmembrane transporter activity
AC612_RS23385	COG0477	Major facilitator Superfamily
AC612_RS23395	COG0583	DNA-binding transcription factor activity
AC612_RS23400	COG4221	oxidoreductase activity
AC612_RS23410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC612_RS23430	COG3328	transposase activity
AC612_RS23455	COG0564	pseudouridine synthase activity
AC612_RS23480	COG3039	Transposase
AC612_RS23495	COG3328	transposase activity
AC612_RS23520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AC612_RS23525	COG1074	ATP-dependent DNA helicase activity
AC612_RS23530	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AC612_RS23565	COG1127	ABC transporter
AC612_RS23570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC612_RS23575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC612_RS23590	COG2853	Lipoprotein
AC612_RS23600	COG0386	Belongs to the glutathione peroxidase family
AC612_RS23630	COG0625	glutathione transferase activity
AC612_RS23680	COG3077	Addiction module antitoxin, RelB DinJ family
AC612_RS23685	COG3041	Addiction module toxin RelE StbE family
AC612_RS23745	COG0840	transmembrane signaling receptor activity
AC612_RS23775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC612_RS23780	COG4691	Plasmid stability protein
AC612_RS23800	COG3328	transposase activity
AC612_RS23820	COG1192	Involved in chromosome partitioning
AC612_RS23840	COG3537	Alpha-1,2-mannosidase
AC612_RS23865	COG1929	Belongs to the glycerate kinase type-1 family
AC612_RS23870	COG2271	Major facilitator Superfamily
AC612_RS23885	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC612_RS23895	COG0861	Integral membrane protein TerC family
AC612_RS23905	COG0584	glycerophosphoryl diester phosphodiesterase
AC612_RS23920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AC612_RS23930	COG0706	membrane insertase activity
AC612_RS23935	COG0594	ribonuclease P activity
AC612_RS23995	COG3328	transposase activity
AC612_RS24000	COG3328	transposase activity
AC612_RS24040	COG3328	transposase activity
AC612_RS24120	COG2951	lytic endotransglycosylase activity
AC612_RS24135	COG3328	transposase activity