locus-tag	class	description
DGN11_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DGN11_RS00020	COG0187	DNA topoisomerase II activity
DGN11_RS00030	COG0501	Belongs to the peptidase M48B family
DGN11_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DGN11_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN11_RS00120	COG0793	Belongs to the peptidase S41A family
DGN11_RS00125	COG4942	peptidase
DGN11_RS00135	COG2234	aminopeptidase activity
DGN11_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN11_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN11_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN11_RS00165	COG1064	alcohol dehydrogenase
DGN11_RS00175	COG0493	'glutamate synthase
DGN11_RS00180	COG0067	glutamate synthase
DGN11_RS00180	COG0069	glutamate synthase activity
DGN11_RS00180	COG0070	glutamate synthase
DGN11_RS00220	COG3328	transposase activity
DGN11_RS00260	COG1111	helicase
DGN11_RS00260	COG1205	dead DEAH box helicase
DGN11_RS00265	COG1272	protein, Hemolysin III
DGN11_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS00290	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS00310	COG2249	NAD(P)H dehydrogenase (quinone) activity
DGN11_RS00330	COG3039	Transposase
DGN11_RS00355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGN11_RS00370	COG1125	glycine betaine transport
DGN11_RS00370	COG0517	IMP dehydrogenase activity
DGN11_RS00385	COG1119	ATPase activity
DGN11_RS00395	COG1752	Esterase of the alpha-beta hydrolase superfamily
DGN11_RS00405	COG1522	sequence-specific DNA binding
DGN11_RS00410	COG3186	Phenylalanine-4-hydroxylase
DGN11_RS00420	COG2755	lipolytic protein G-D-S-L family
DGN11_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS00435	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DGN11_RS00440	COG1609	Transcriptional regulator
DGN11_RS00445	COG3507	Belongs to the glycosyl hydrolase 43 family
DGN11_RS00460	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DGN11_RS00470	COG2755	lipolytic protein G-D-S-L family
DGN11_RS00470	COG0657	acetylesterase activity
DGN11_RS00490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN11_RS00495	COG0366	Alpha amylase catalytic
DGN11_RS00500	COG0366	Alpha amylase catalytic
DGN11_RS00505	COG3039	Transposase
DGN11_RS00530	COG3039	Transposase
DGN11_RS00555	COG3328	transposase activity
DGN11_RS00580	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DGN11_RS00585	COG3710	Transcriptional regulator
DGN11_RS00605	COG2197	response regulator
DGN11_RS00610	COG4585	Histidine kinase
DGN11_RS00620	COG1304	FMN binding
DGN11_RS00645	COG1012	belongs to the aldehyde dehydrogenase family
DGN11_RS00660	COG4772	TonB-dependent receptor
DGN11_RS00670	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DGN11_RS00700	COG0714	Associated with various cellular activities
DGN11_RS00740	COG0477	Major facilitator Superfamily
DGN11_RS00745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN11_RS00790	COG3237	CsbD-like
DGN11_RS00800	COG3039	Transposase
DGN11_RS00810	COG0489	protein tyrosine kinase activity
DGN11_RS00815	COG2062	phosphohistidine phosphatase, SixA
DGN11_RS00825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN11_RS00870	COG1968	undecaprenyl-diphosphatase activity
DGN11_RS00875	COG0174	glutamine synthetase
DGN11_RS00880	COG0347	Belongs to the P(II) protein family
DGN11_RS00885	COG0004	ammonium transporteR
DGN11_RS00895	COG3852	Histidine kinase
DGN11_RS00900	COG2204	response regulator
DGN11_RS00905	COG2032	superoxide dismutase activity
DGN11_RS00910	COG2032	superoxide dismutase activity
DGN11_RS00920	COG3039	Transposase
DGN11_RS00935	COG0183	Belongs to the thiolase family
DGN11_RS00970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DGN11_RS00975	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DGN11_RS00980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DGN11_RS00995	COG0028	Belongs to the TPP enzyme family
DGN11_RS01000	COG2205	protein histidine kinase activity
DGN11_RS01025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DGN11_RS01040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN11_RS01050	COG0596	Alpha beta hydrolase
DGN11_RS01055	COG0727	PFAM Uncharacterised protein family (UPF0153)
DGN11_RS01060	COG0318	PFAM AMP-dependent synthetase and ligase
DGN11_RS01065	COG0745	RESPONSE REGULATOR receiver
DGN11_RS01075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN11_RS01095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGN11_RS01105	COG0564	pseudouridine synthase activity
DGN11_RS01125	COG1446	asparaginase
DGN11_RS01130	COG0339	signal peptide processing
DGN11_RS01165	COG0475	glutathione-regulated potassium exporter activity
DGN11_RS01170	COG0583	DNA-binding transcription factor activity
DGN11_RS01175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DGN11_RS01180	COG2224	Isocitrate lyase
DGN11_RS01210	COG4770	biotin carboxylase activity
DGN11_RS01215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DGN11_RS01220	COG1960	acyl-CoA dehydrogenase activity
DGN11_RS01285	COG0697	spore germination
DGN11_RS01295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DGN11_RS01300	COG1846	Transcriptional regulator
DGN11_RS01305	COG1764	response to oxidative stress
DGN11_RS01330	COG2130	NADP-dependent
DGN11_RS01345	COG1187	pseudouridine synthase activity
DGN11_RS01360	COG1643	Atp-dependent helicase
DGN11_RS01365	COG4807	Protein conserved in bacteria
DGN11_RS01370	COG2351	hydroxyisourate hydrolase activity
DGN11_RS01375	COG2072	flavoprotein involved in K transport
DGN11_RS01395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DGN11_RS01405	COG0583	DNA-binding transcription factor activity
DGN11_RS01440	COG2252	PERMEase
DGN11_RS01460	COG0084	hydrolase, TatD family'
DGN11_RS01470	COG0583	DNA-binding transcription factor activity
DGN11_RS01475	COG2814	Major facilitator Superfamily
DGN11_RS01485	COG2267	carboxylic ester hydrolase activity
DGN11_RS01490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DGN11_RS01495	COG1902	pentaerythritol trinitrate reductase activity
DGN11_RS01515	COG0745	RESPONSE REGULATOR receiver
DGN11_RS01520	COG2205	protein histidine kinase activity
DGN11_RS01525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN11_RS01545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGN11_RS01550	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGN11_RS01555	COG0583	DNA-binding transcription factor activity
DGN11_RS01585	COG0702	epimerase
DGN11_RS01590	COG1733	regulation of RNA biosynthetic process
DGN11_RS01625	COG3328	transposase activity
DGN11_RS01640	COG3039	Transposase
DGN11_RS01650	COG0129	dihydroxy-acid dehydratase activity
DGN11_RS01665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DGN11_RS01720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DGN11_RS01725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DGN11_RS01750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DGN11_RS01755	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DGN11_RS01765	COG3485	protocatechuate 3,4-dioxygenase
DGN11_RS01770	COG3485	protocatechuate 3,4-dioxygenase
DGN11_RS01780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN11_RS01785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DGN11_RS01795	COG1414	Transcriptional regulator
DGN11_RS01805	COG0657	acetylesterase activity
DGN11_RS01815	COG0445	tRNA wobble uridine modification
DGN11_RS01825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DGN11_RS01850	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS01855	COG2267	carboxylic ester hydrolase activity
DGN11_RS01865	COG0156	8-amino-7-oxononanoate synthase activity
DGN11_RS01870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DGN11_RS01875	COG1040	competence protein
DGN11_RS01880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DGN11_RS01905	COG3039	Transposase
DGN11_RS01970	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DGN11_RS02040	COG1511	domain protein
DGN11_RS02040	COG3264	Mechanosensitive ion channel
DGN11_RS02045	COG1368	sulfuric ester hydrolase activity
DGN11_RS02050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGN11_RS02055	COG2354	Protein conserved in bacteria
DGN11_RS02065	COG0297	glycogen (starch) synthase activity
DGN11_RS02070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN11_RS02075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN11_RS02100	COG0702	epimerase
DGN11_RS02105	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS02135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN11_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS02150	COG0513	Belongs to the DEAD box helicase family
DGN11_RS02155	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGN11_RS02170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DGN11_RS02180	COG3483	tryptophan 2,3-dioxygenase activity
DGN11_RS02185	COG3104	oligopeptide transport
DGN11_RS02220	COG1320	monovalent cation:proton antiporter activity
DGN11_RS02225	COG2212	antiporter activity
DGN11_RS02235	COG0651	ATP synthesis coupled electron transport
DGN11_RS02240	COG1006	Multisubunit Na H antiporter MnhC subunit
DGN11_RS02245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGN11_RS02245	COG2111	Na H antiporter
DGN11_RS02270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DGN11_RS02275	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DGN11_RS02290	COG0456	acetyltransferase
DGN11_RS02295	COG1597	lipid kinase activity
DGN11_RS02315	COG0582	viral genome integration into host DNA
DGN11_RS02330	COG3039	Transposase
DGN11_RS02350	COG3039	Transposase
DGN11_RS02370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DGN11_RS02375	COG0134	indole-3-glycerol-phosphate synthase activity
DGN11_RS02385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN11_RS02390	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DGN11_RS02400	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DGN11_RS02410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DGN11_RS02425	COG1051	belongs to the nudix hydrolase family
DGN11_RS02465	COG0316	Belongs to the HesB IscA family
DGN11_RS02480	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGN11_RS02495	COG2814	Major facilitator Superfamily
DGN11_RS02505	COG2814	Major facilitator Superfamily
DGN11_RS02510	COG1289	transmembrane transporter activity
DGN11_RS02515	COG0151	Belongs to the GarS family
DGN11_RS02525	COG0138	bifunctional purine biosynthesis protein purh
DGN11_RS02530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGN11_RS02540	COG0671	phosphoesterase, PA-phosphatase related
DGN11_RS02540	COG2453	phosphatase
DGN11_RS02565	COG4589	Belongs to the CDS family
DGN11_RS02570	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DGN11_RS02595	COG2264	protein methyltransferase activity
DGN11_RS02615	COG0439	Biotin carboxylase
DGN11_RS02625	COG0511	ligase activity, forming carbon-carbon bonds
DGN11_RS02630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DGN11_RS02640	COG1324	tolerance protein
DGN11_RS02650	COG2356	endonuclease I
DGN11_RS02660	COG0459	protein refolding
DGN11_RS02675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DGN11_RS02690	COG3386	PFAM SMP-30 Gluconolaconase
DGN11_RS02700	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DGN11_RS02705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGN11_RS02730	COG0778	Nitroreductase
DGN11_RS02735	COG2353	YceI-like domain
DGN11_RS02760	COG3052	prosthetic group binding
DGN11_RS02785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGN11_RS02795	COG1802	Transcriptional regulator
DGN11_RS02855	COG3328	transposase activity
DGN11_RS02880	COG3039	Transposase
DGN11_RS02915	COG3328	transposase activity
DGN11_RS02940	COG1082	Xylose isomerase domain protein TIM barrel
DGN11_RS02950	COG3328	transposase activity
DGN11_RS02960	COG3039	Transposase
DGN11_RS02965	COG4221	oxidoreductase activity
DGN11_RS02980	COG4221	oxidoreductase activity
DGN11_RS02990	COG0435	Glutathione S-transferase
DGN11_RS03025	COG0823	Involved in the tonB-independent uptake of proteins
DGN11_RS03025	COG1506	peptidase
DGN11_RS03060	COG0697	spore germination
DGN11_RS03075	COG1113	amino acid transport
DGN11_RS03095	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DGN11_RS03140	COG0840	transmembrane signaling receptor activity
DGN11_RS03145	COG5297	Belongs to the glycosyl hydrolase family 6
DGN11_RS03145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN11_RS03150	COG0659	secondary active sulfate transmembrane transporter activity
DGN11_RS03165	COG2943	transferase activity, transferring hexosyl groups
DGN11_RS03175	COG3275	phosphorelay sensor kinase activity
DGN11_RS03185	COG0181	hydroxymethylbilane synthase activity
DGN11_RS03210	COG1505	serine-type exopeptidase activity
DGN11_RS03215	COG0436	Aminotransferase
DGN11_RS03225	COG2832	Protein of unknown function (DUF454)
DGN11_RS03235	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DGN11_RS03245	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DGN11_RS03250	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DGN11_RS03255	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DGN11_RS03280	COG2226	methyltransferase
DGN11_RS03285	COG3300	MHYT domain
DGN11_RS03285	COG5001	Diguanylate cyclase
DGN11_RS03290	COG0308	aminopeptidase N
DGN11_RS03340	COG3284	Transcriptional regulator
DGN11_RS03345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN11_RS03350	COG1077	Cell shape determining protein MreB Mrl
DGN11_RS03355	COG1792	Involved in formation and maintenance of cell shape
DGN11_RS03370	COG0772	Belongs to the SEDS family
DGN11_RS03380	COG2951	lytic endotransglycosylase activity
DGN11_RS03385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DGN11_RS03390	COG1686	Belongs to the peptidase S11 family
DGN11_RS03400	COG2921	Belongs to the UPF0250 family
DGN11_RS03405	COG0321	lipoyl(octanoyl) transferase activity
DGN11_RS03410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DGN11_RS03435	COG1051	belongs to the nudix hydrolase family
DGN11_RS03435	COG1056	cytidyltransferase-related domain
DGN11_RS03470	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DGN11_RS03475	COG0673	inositol 2-dehydrogenase activity
DGN11_RS03480	COG2823	Periplasmic or secreted lipoprotein
DGN11_RS03485	COG4251	negative regulation of phosphorylation
DGN11_RS03490	COG0784	Response regulator, receiver
DGN11_RS03495	COG4191	Histidine kinase
DGN11_RS03500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DGN11_RS03555	COG1459	type II secretion system
DGN11_RS03560	COG2165	general secretion pathway protein
DGN11_RS03575	COG4795	General secretion pathway protein
DGN11_RS03605	COG3250	beta-galactosidase activity
DGN11_RS03620	COG2188	Transcriptional regulator
DGN11_RS03630	COG1609	Transcriptional regulator
DGN11_RS03635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGN11_RS03640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DGN11_RS03655	COG0617	tRNA 3'-terminal CCA addition
DGN11_RS03660	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGN11_RS03665	COG1012	belongs to the aldehyde dehydrogenase family
DGN11_RS03670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DGN11_RS03685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGN11_RS03700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DGN11_RS03720	COG2205	protein histidine kinase activity
DGN11_RS03750	COG3791	Glutathione-dependent formaldehyde-activating
DGN11_RS03765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGN11_RS03785	COG0488	(ABC) transporter
DGN11_RS03795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DGN11_RS03800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DGN11_RS03810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGN11_RS03810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGN11_RS03830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DGN11_RS03835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGN11_RS03840	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DGN11_RS03860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DGN11_RS03865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DGN11_RS03870	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DGN11_RS03875	COG2205	protein histidine kinase activity
DGN11_RS03880	COG0745	RESPONSE REGULATOR receiver
DGN11_RS03885	COG0277	FAD linked oxidase domain protein
DGN11_RS03890	COG1988	membrane-bound metal-dependent
DGN11_RS03895	COG0792	nuclease activity
DGN11_RS03925	COG0275	rRNA processing
DGN11_RS03930	COG3116	cell division
DGN11_RS03940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DGN11_RS03945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DGN11_RS03950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGN11_RS03960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DGN11_RS03965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGN11_RS03970	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGN11_RS03975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DGN11_RS03990	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DGN11_RS04000	COG0739	heme binding
DGN11_RS04005	COG0653	protein targeting
DGN11_RS04010	COG0494	nUDIX hydrolase
DGN11_RS04020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGN11_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS04030	COG3321	synthase
DGN11_RS04030	COG0604	alcohol dehydrogenase
DGN11_RS04050	COG0366	Alpha amylase catalytic
DGN11_RS04085	COG2226	methyltransferase
DGN11_RS04090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DGN11_RS04100	COG3328	transposase activity
DGN11_RS04105	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DGN11_RS04145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DGN11_RS04155	COG4106	trans-aconitate 2-methyltransferase activity
DGN11_RS04160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGN11_RS04170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN11_RS04175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DGN11_RS04185	COG0667	Aldo Keto reductase
DGN11_RS04195	COG4771	TonB-dependent receptor
DGN11_RS04215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN11_RS04220	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DGN11_RS04230	COG2175	clavaminate synthase activity
DGN11_RS04240	COG4181	ATPase activity
DGN11_RS04255	COG0642	Histidine kinase
DGN11_RS04265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DGN11_RS04285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DGN11_RS04290	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DGN11_RS04305	COG3829	transcription factor binding
DGN11_RS04315	COG1116	anion transmembrane transporter activity
DGN11_RS04320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN11_RS04330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGN11_RS04335	COG0431	NADPH-dependent FMN reductase
DGN11_RS04360	COG0747	negative chemotaxis
DGN11_RS04370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DGN11_RS04380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DGN11_RS04385	COG2967	ApaG domain
DGN11_RS04390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DGN11_RS04395	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DGN11_RS04400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN11_RS04405	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DGN11_RS04415	COG0123	including yeast histone deacetylase and acetoin utilization protein
DGN11_RS04420	COG2096	Adenosyltransferase
DGN11_RS04435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN11_RS04440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN11_RS04470	COG3384	dioxygenase
DGN11_RS04475	COG0583	DNA-binding transcription factor activity
DGN11_RS04490	COG1024	Enoyl-CoA hydratase
DGN11_RS04520	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DGN11_RS04545	COG0697	spore germination
DGN11_RS04555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN11_RS04580	COG2197	response regulator
DGN11_RS04590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DGN11_RS04600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DGN11_RS04605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN11_RS04610	COG0583	DNA-binding transcription factor activity
DGN11_RS04615	COG3634	alkyl hydroperoxide reductase activity
DGN11_RS04625	COG2890	protein-(glutamine-N5) methyltransferase activity
DGN11_RS04645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGN11_RS04645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGN11_RS04665	COG3039	Transposase
DGN11_RS04680	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DGN11_RS04720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGN11_RS04725	COG1404	Belongs to the peptidase S8 family
DGN11_RS04730	COG1404	Belongs to the peptidase S8 family
DGN11_RS04735	COG1404	Belongs to the peptidase S8 family
DGN11_RS04740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DGN11_RS04765	COG1295	ribonuclease BN
DGN11_RS04770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN11_RS04775	COG1254	Belongs to the acylphosphatase family
DGN11_RS04790	COG0521	Mo-molybdopterin cofactor biosynthetic process
DGN11_RS04800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DGN11_RS04805	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DGN11_RS04815	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DGN11_RS04820	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DGN11_RS04830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DGN11_RS04835	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DGN11_RS04840	COG0193	aminoacyl-tRNA hydrolase activity
DGN11_RS04845	COG0012	GTP binding
DGN11_RS04865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGN11_RS04880	COG0250	Participates in transcription elongation, termination and antitermination
DGN11_RS04885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DGN11_RS04890	COG0081	regulation of translation
DGN11_RS04895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DGN11_RS04900	COG0222	ribosome binding
DGN11_RS04905	COG0085	RNA polymerase activity
DGN11_RS04910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DGN11_RS04915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DGN11_RS04920	COG0049	tRNA binding
DGN11_RS04925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DGN11_RS04930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGN11_RS04935	COG0051	transcription antitermination factor activity, RNA binding
DGN11_RS04940	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DGN11_RS04945	COG0088	Forms part of the polypeptide exit tunnel
DGN11_RS04950	COG0089	rRNA binding
DGN11_RS04955	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DGN11_RS04960	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DGN11_RS04970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DGN11_RS04975	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DGN11_RS04980	COG0255	Belongs to the universal ribosomal protein uL29 family
DGN11_RS04985	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DGN11_RS04995	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DGN11_RS05000	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DGN11_RS05010	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DGN11_RS05015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DGN11_RS05020	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DGN11_RS05030	COG1841	ribosomal large subunit assembly
DGN11_RS05035	COG0200	Binds to the 23S rRNA
DGN11_RS05040	COG0201	protein transport
DGN11_RS05065	COG0203	ribosomal protein L17
DGN11_RS05070	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DGN11_RS05085	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DGN11_RS05100	COG0154	amidase activity
DGN11_RS05110	COG1217	gtp-binding protein TYPA
DGN11_RS05115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DGN11_RS05120	COG0039	L-malate dehydrogenase activity
DGN11_RS05125	COG0625	glutathione transferase activity
DGN11_RS05135	COG1902	pentaerythritol trinitrate reductase activity
DGN11_RS05135	COG0446	pyridine nucleotide-disulphide oxidoreductase
DGN11_RS05140	COG0604	alcohol dehydrogenase
DGN11_RS05165	COG0156	8-amino-7-oxononanoate synthase activity
DGN11_RS05175	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DGN11_RS05180	COG4208	sulfate ABC transporter
DGN11_RS05185	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DGN11_RS05215	COG0406	alpha-ribazole phosphatase activity
DGN11_RS05220	COG0285	dihydrofolate synthase activity
DGN11_RS05240	COG2833	Protein of unknown function (DUF455)
DGN11_RS05255	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN11_RS05260	COG0671	phosphoesterase, PA-phosphatase related
DGN11_RS05265	COG0438	transferase activity, transferring glycosyl groups
DGN11_RS05275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DGN11_RS05290	COG4783	chaperone-mediated protein folding
DGN11_RS05305	COG0473	3-isopropylmalate dehydrogenase activity
DGN11_RS05545	COG4695	Portal protein
DGN11_RS05575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DGN11_RS05600	COG3852	Histidine kinase
DGN11_RS05610	COG0544	peptidyl-prolyl cis-trans isomerase activity
DGN11_RS05620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DGN11_RS05650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN11_RS05660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN11_RS05670	COG0328	RNA-DNA hybrid ribonuclease activity
DGN11_RS05675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGN11_RS05680	COG0631	protein serine/threonine phosphatase activity
DGN11_RS05695	COG0859	PFAM glycosyl transferase family 9
DGN11_RS05700	COG3642	lipopolysaccharide core region biosynthetic process
DGN11_RS05705	COG1234	tRNA 3'-trailer cleavage
DGN11_RS05710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DGN11_RS05720	COG0315	cyclic pyranopterin monophosphate synthase activity
DGN11_RS05725	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DGN11_RS05730	COG0314	molybdopterin synthase activity
DGN11_RS05760	COG3328	transposase activity
DGN11_RS05770	COG3328	transposase activity
DGN11_RS05835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DGN11_RS05840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DGN11_RS05845	COG0537	adenosine 5'-monophosphoramidase activity
DGN11_RS05865	COG0714	Associated with various cellular activities
DGN11_RS05890	COG0424	maF-like protein
DGN11_RS05895	COG1399	metal-binding, possibly nucleic acid-binding protein
DGN11_RS05905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN11_RS05915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGN11_RS05920	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS05935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DGN11_RS05940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DGN11_RS05965	COG3829	transcription factor binding
DGN11_RS06005	COG2373	Large extracellular alpha-helical protein
DGN11_RS06020	COG4953	penicillin-binding protein 1C
DGN11_RS06030	COG0678	peroxiredoxin activity
DGN11_RS06050	COG0330	HflC and HflK could
DGN11_RS06055	COG0330	HflC and HflK could
DGN11_RS06060	COG3039	Transposase
DGN11_RS06070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DGN11_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS06090	COG1309	transcriptional regulator
DGN11_RS06130	COG3039	Transposase
DGN11_RS06140	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DGN11_RS06145	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
DGN11_RS06150	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
DGN11_RS06155	COG3039	Transposase
DGN11_RS06160	COG3039	Transposase
DGN11_RS06165	COG0732	type I restriction modification DNA specificity domain
DGN11_RS06170	COG3328	transposase activity
DGN11_RS06200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGN11_RS06210	COG3387	PFAM Glycoside hydrolase 15-related
DGN11_RS06215	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS06220	COG3537	Alpha-1,2-mannosidase
DGN11_RS06225	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS06240	COG0492	ferredoxin-NADP+ reductase activity
DGN11_RS06275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGN11_RS06280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGN11_RS06285	COG2080	2 iron, 2 sulfur cluster binding
DGN11_RS06320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGN11_RS06335	COG0587	DNA-directed DNA polymerase activity
DGN11_RS06355	COG1297	OPT oligopeptide transporter protein
DGN11_RS06370	COG0823	Involved in the tonB-independent uptake of proteins
DGN11_RS06370	COG1506	peptidase
DGN11_RS06385	COG1917	Cupin 2, conserved barrel domain protein
DGN11_RS06385	COG2207	Transcriptional regulator
DGN11_RS06405	COG0753	catalase activity
DGN11_RS06410	COG0656	L-ascorbic acid biosynthetic process
DGN11_RS06420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGN11_RS06420	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGN11_RS06425	COG2814	Major facilitator Superfamily
DGN11_RS06440	COG2194	sulfuric ester hydrolase activity
DGN11_RS06455	COG0745	RESPONSE REGULATOR receiver
DGN11_RS06460	COG0642	Histidine kinase
DGN11_RS06470	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DGN11_RS06475	COG2894	cell division
DGN11_RS06480	COG0850	regulation of cytokinetic process
DGN11_RS06490	COG4585	Histidine kinase
DGN11_RS06495	COG2197	response regulator
DGN11_RS06510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DGN11_RS06535	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DGN11_RS06545	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DGN11_RS06565	COG1946	Acyl-CoA thioesterase
DGN11_RS06580	COG0824	Thioesterase
DGN11_RS06585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DGN11_RS06590	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DGN11_RS06595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DGN11_RS06600	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DGN11_RS06605	COG0268	Binds directly to 16S ribosomal RNA
DGN11_RS06615	COG0196	riboflavin kinase activity
DGN11_RS06620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DGN11_RS06625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DGN11_RS06630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DGN11_RS06645	COG3039	Transposase
DGN11_RS06650	COG3328	transposase activity
DGN11_RS06655	COG3039	Transposase
DGN11_RS06675	COG3328	transposase activity
DGN11_RS06700	COG0189	ligase activity
DGN11_RS06710	COG0745	RESPONSE REGULATOR receiver
DGN11_RS06725	COG3039	Transposase
DGN11_RS06740	COG3328	transposase activity
DGN11_RS06745	COG0237	dephospho-CoA kinase activity
DGN11_RS06750	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DGN11_RS06755	COG1459	type II secretion system
DGN11_RS06785	COG0045	succinate-CoA ligase (ADP-forming) activity
DGN11_RS06790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DGN11_RS06800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGN11_RS06800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DGN11_RS06810	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN11_RS06815	COG0564	pseudouridine synthase activity
DGN11_RS06830	COG3011	Protein conserved in bacteria
DGN11_RS06835	COG0840	transmembrane signaling receptor activity
DGN11_RS06850	COG3387	PFAM Glycoside hydrolase 15-related
DGN11_RS06855	COG1877	trehalose-phosphatase activity
DGN11_RS06895	COG2827	Endonuclease containing a URI domain
DGN11_RS06900	COG4771	TonB-dependent receptor
DGN11_RS06905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGN11_RS06910	COG0667	Aldo Keto reductase
DGN11_RS06915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DGN11_RS06920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN11_RS06925	COG1116	anion transmembrane transporter activity
DGN11_RS06930	COG0542	response to heat
DGN11_RS06935	COG4206	TonB-dependent receptor
DGN11_RS06960	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGN11_RS06970	COG1492	cobalamin metabolic process
DGN11_RS06980	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DGN11_RS07005	COG0019	diaminopimelate decarboxylase activity
DGN11_RS07020	COG4264	IucA IucC family
DGN11_RS07030	COG4772	TonB-dependent receptor
DGN11_RS07040	COG4651	solute:proton antiporter activity
DGN11_RS07040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGN11_RS07070	COG0488	(ABC) transporter
DGN11_RS07110	COG0477	Major facilitator Superfamily
DGN11_RS07125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DGN11_RS07140	COG0217	transcriptional regulatory protein
DGN11_RS07145	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DGN11_RS07150	COG0632	four-way junction helicase activity
DGN11_RS07155	COG3158	transport of potassium into the cell
DGN11_RS07160	COG2255	four-way junction helicase activity
DGN11_RS07165	COG0824	Thioesterase
DGN11_RS07175	COG0848	biopolymer transport protein
DGN11_RS07185	COG0823	Involved in the tonB-independent uptake of proteins
DGN11_RS07190	COG2885	chlorophyll binding
DGN11_RS07200	COG0602	queuosine metabolic process
DGN11_RS07210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DGN11_RS07215	COG3920	Histidine kinase
DGN11_RS07235	COG0840	transmembrane signaling receptor activity
DGN11_RS07280	COG0514	ATP-dependent DNA helicase (RecQ)
DGN11_RS07285	COG0783	Belongs to the Dps family
DGN11_RS07290	COG1643	Atp-dependent helicase
DGN11_RS07300	COG0837	glucose binding
DGN11_RS07315	COG0535	radical SAM domain protein
DGN11_RS07320	COG0535	radical SAM domain protein
DGN11_RS07325	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DGN11_RS07330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DGN11_RS07340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGN11_RS07350	COG1215	transferase activity, transferring glycosyl groups
DGN11_RS07355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGN11_RS07365	COG1199	ATP-dependent helicase activity
DGN11_RS07375	COG1397	ADP-ribosylglycohydrolase
DGN11_RS07385	COG0189	ligase activity
DGN11_RS07400	COG0835	chemotaxis
DGN11_RS07405	COG0840	transmembrane signaling receptor activity
DGN11_RS07410	COG0784	Response regulator, receiver
DGN11_RS07410	COG0643	Histidine kinase
DGN11_RS07410	COG2198	Histidine kinase
DGN11_RS07430	COG1446	asparaginase
DGN11_RS07435	COG3142	Participates in the control of copper homeostasis
DGN11_RS07470	COG3537	Alpha-1,2-mannosidase
DGN11_RS07480	COG1486	melibiose metabolic process
DGN11_RS07490	COG0531	amino acid
DGN11_RS07510	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN11_RS07520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DGN11_RS07525	COG1388	LysM domain
DGN11_RS07525	COG3858	chitin binding
DGN11_RS07540	COG0837	glucose binding
DGN11_RS07545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DGN11_RS07555	COG0494	nUDIX hydrolase
DGN11_RS07560	COG1218	3'(2'),5'-bisphosphate nucleotidase
DGN11_RS07565	COG3956	TIGRFAM MazG family protein
DGN11_RS07570	COG1742	UPF0060 membrane protein
DGN11_RS07590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DGN11_RS07595	COG0509	glycine decarboxylation via glycine cleavage system
DGN11_RS07615	COG3328	transposase activity
DGN11_RS07640	COG1960	acyl-CoA dehydrogenase activity
DGN11_RS07650	COG1309	transcriptional regulator
DGN11_RS07655	COG3039	Transposase
DGN11_RS07665	COG3328	transposase activity
DGN11_RS07670	COG3039	Transposase
DGN11_RS07675	COG4771	TonB-dependent receptor
DGN11_RS07685	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DGN11_RS07690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGN11_RS07695	COG0463	Glycosyl transferase, family 2
DGN11_RS07700	COG0516	GMP reductase activity
DGN11_RS07700	COG0517	IMP dehydrogenase activity
DGN11_RS07705	COG2982	Protein involved in outer membrane biogenesis
DGN11_RS07710	COG1272	protein, Hemolysin III
DGN11_RS07715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DGN11_RS07720	COG0739	heme binding
DGN11_RS07725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN11_RS07730	COG0626	cystathionine gamma-synthase activity
DGN11_RS07735	COG0460	homoserine dehydrogenase
DGN11_RS07735	COG0527	aspartate kinase activity
DGN11_RS07745	COG1760	l-serine dehydratase
DGN11_RS07765	COG2353	YceI-like domain
DGN11_RS07770	COG0784	Response regulator, receiver
DGN11_RS07770	COG2198	Histidine kinase
DGN11_RS07770	COG2205	protein histidine kinase activity
DGN11_RS07790	COG2814	Major facilitator Superfamily
DGN11_RS07795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DGN11_RS07805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DGN11_RS07810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DGN11_RS07815	COG0259	pyridoxamine-phosphate oxidase activity
DGN11_RS07825	COG1842	Phage shock protein A
DGN11_RS07850	COG0754	glutathionylspermidine amidase activity
DGN11_RS07860	COG2814	Major facilitator Superfamily
DGN11_RS07930	COG0531	amino acid
DGN11_RS07935	COG2197	response regulator
DGN11_RS07955	COG3328	transposase activity
DGN11_RS07960	COG1113	amino acid transport
DGN11_RS07970	COG1271	oxidase subunit
DGN11_RS07975	COG1294	oxidase, subunit
DGN11_RS07985	COG2239	Acts as a magnesium transporter
DGN11_RS07990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGN11_RS07995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN11_RS08005	COG1660	Displays ATPase and GTPase activities
DGN11_RS08010	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DGN11_RS08015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN11_RS08030	COG1137	ATPase activity
DGN11_RS08035	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DGN11_RS08045	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DGN11_RS08055	COG0271	Belongs to the BolA IbaG family
DGN11_RS08060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DGN11_RS08080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DGN11_RS08090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DGN11_RS08100	COG0628	permease
DGN11_RS08110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DGN11_RS08115	COG3178	'Phosphotransferase
DGN11_RS08130	COG1555	photosystem II stabilization
DGN11_RS08140	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN11_RS08145	COG1477	protein flavinylation
DGN11_RS08170	COG3128	pkhd-type hydroxylase
DGN11_RS08175	COG4774	siderophore transport
DGN11_RS08180	COG2146	nitrite reductase [NAD(P)H] activity
DGN11_RS08190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DGN11_RS08195	COG0719	Fe-S assembly protein
DGN11_RS08200	COG0396	ATPase activity
DGN11_RS08205	COG0719	Fe-S assembly protein
DGN11_RS08210	COG1959	2 iron, 2 sulfur cluster binding
DGN11_RS08220	COG0693	protein deglycase activity
DGN11_RS08240	COG0739	heme binding
DGN11_RS08255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DGN11_RS08280	COG0519	Catalyzes the synthesis of GMP from XMP
DGN11_RS08285	COG1678	Uncharacterized ACR, COG1678
DGN11_RS08290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DGN11_RS08295	COG0540	Belongs to the ATCase OTCase family
DGN11_RS08300	COG1764	response to oxidative stress
DGN11_RS08310	COG0384	phenazine biosynthesis protein PhzF
DGN11_RS08315	COG0384	phenazine biosynthesis protein PhzF
DGN11_RS08320	COG0527	aspartate kinase activity
DGN11_RS08335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DGN11_RS08350	COG0142	geranyltranstransferase activity
DGN11_RS08355	COG0629	single-stranded DNA binding
DGN11_RS08360	COG2203	Gaf domain
DGN11_RS08360	COG3706	GGDEF domain
DGN11_RS08360	COG4251	negative regulation of phosphorylation
DGN11_RS08360	COG5001	Diguanylate cyclase
DGN11_RS08365	COG0604	alcohol dehydrogenase
DGN11_RS08365	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS08365	COG3321	synthase
DGN11_RS08370	COG2080	2 iron, 2 sulfur cluster binding
DGN11_RS08375	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGN11_RS08380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGN11_RS08385	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DGN11_RS08420	COG2879	small protein
DGN11_RS08425	COG1966	Carbon starvation protein
DGN11_RS08430	COG1741	Belongs to the pirin family
DGN11_RS08445	COG1741	Belongs to the pirin family
DGN11_RS08450	COG3328	transposase activity
DGN11_RS08460	COG1515	deoxyribonuclease V activity
DGN11_RS08465	COG0588	phosphoglycerate mutase activity
DGN11_RS08475	COG3590	peptidase
DGN11_RS08480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN11_RS08485	COG2201	protein-glutamate methylesterase activity
DGN11_RS08490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGN11_RS08495	COG2199	diguanylate cyclase activity
DGN11_RS08495	COG2200	EAL domain
DGN11_RS08495	COG2202	Pas domain
DGN11_RS08500	COG0835	chemotaxis
DGN11_RS08505	COG0840	transmembrane signaling receptor activity
DGN11_RS08510	COG0643	Histidine kinase
DGN11_RS08510	COG2198	Histidine kinase
DGN11_RS08520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DGN11_RS08530	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DGN11_RS08535	COG0745	RESPONSE REGULATOR receiver
DGN11_RS08540	COG2205	protein histidine kinase activity
DGN11_RS08550	COG4452	Inner membrane protein CreD
DGN11_RS08575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN11_RS08580	COG0735	belongs to the Fur family
DGN11_RS08595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN11_RS08605	COG1309	transcriptional regulator
DGN11_RS08615	COG2207	Transcriptional regulator
DGN11_RS08625	COG0583	DNA-binding transcription factor activity
DGN11_RS08630	COG2814	Major facilitator Superfamily
DGN11_RS08635	COG0667	Aldo Keto reductase
DGN11_RS08735	COG1595	DNA-templated transcription, initiation
DGN11_RS08745	COG5001	Diguanylate cyclase
DGN11_RS08745	COG5002	protein histidine kinase activity
DGN11_RS08750	COG1187	pseudouridine synthase activity
DGN11_RS08770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGN11_RS08780	COG0475	glutathione-regulated potassium exporter activity
DGN11_RS08785	COG5000	phosphorelay sensor kinase activity
DGN11_RS08785	COG5002	protein histidine kinase activity
DGN11_RS08790	COG0745	RESPONSE REGULATOR receiver
DGN11_RS08795	COG1538	Outer membrane efflux protein
DGN11_RS08820	COG1132	(ABC) transporter
DGN11_RS08865	COG2155	Conserved Protein
DGN11_RS08910	COG3118	belongs to the thioredoxin family
DGN11_RS08920	COG0495	leucyl-tRNA aminoacylation
DGN11_RS08935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DGN11_RS08950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DGN11_RS08965	COG2968	Membrane
DGN11_RS08970	COG0424	maF-like protein
DGN11_RS08980	COG3164	Protein of unknown function
DGN11_RS08990	COG0312	modulator of DNA gyrase
DGN11_RS08995	COG3028	Belongs to the UPF0307 family
DGN11_RS09000	COG0312	modulator of DNA gyrase
DGN11_RS09010	COG4104	PAAR repeat-containing protein
DGN11_RS09015	COG0142	geranyltranstransferase activity
DGN11_RS09020	COG1722	exodeoxyribonuclease VII activity
DGN11_RS09025	COG0037	tRNA processing
DGN11_RS09030	COG1785	Belongs to the alkaline phosphatase family
DGN11_RS09035	COG1301	dicarboxylic acid transport
DGN11_RS09040	COG4106	trans-aconitate 2-methyltransferase activity
DGN11_RS09050	COG0791	NLP P60 protein
DGN11_RS09055	COG0791	NLP P60 protein
DGN11_RS09060	COG1047	Peptidyl-prolyl cis-trans
DGN11_RS09065	COG2311	Membrane
DGN11_RS09070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN11_RS09075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGN11_RS09095	COG3590	peptidase
DGN11_RS09100	COG3590	peptidase
DGN11_RS09110	COG3039	Transposase
DGN11_RS09125	COG0489	protein tyrosine kinase activity
DGN11_RS09130	COG0717	Belongs to the dCTP deaminase family
DGN11_RS09185	COG3328	transposase activity
DGN11_RS09190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGN11_RS09195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN11_RS09210	COG0494	nUDIX hydrolase
DGN11_RS09215	COG0433	COG0433 Predicted ATPase
DGN11_RS09225	COG0688	phosphatidylethanolamine metabolic process
DGN11_RS09235	COG2890	protein-(glutamine-N5) methyltransferase activity
DGN11_RS09240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DGN11_RS09245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DGN11_RS09250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DGN11_RS09265	COG0101	tRNA pseudouridine synthase activity
DGN11_RS09270	COG0135	phosphoribosylanthranilate isomerase activity
DGN11_RS09280	COG0133	tryptophan synthase activity
DGN11_RS09290	COG0159	tryptophan synthase activity
DGN11_RS09295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DGN11_RS09300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGN11_RS09330	COG3039	Transposase
DGN11_RS09335	COG0300	oxidoreductase activity
DGN11_RS09340	COG0149	triose-phosphate isomerase activity
DGN11_RS09355	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN11_RS09360	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN11_RS09365	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN11_RS09370	COG0649	NAD binding
DGN11_RS09375	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DGN11_RS09380	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DGN11_RS09390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DGN11_RS09395	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN11_RS09420	COG1007	ATP synthesis coupled electron transport
DGN11_RS09430	COG0779	Required for maturation of 30S ribosomal subunits
DGN11_RS09435	COG0195	Participates in both transcription termination and antitermination
DGN11_RS09440	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DGN11_RS09445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DGN11_RS09450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DGN11_RS09455	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DGN11_RS09460	COG1185	polyribonucleotide nucleotidyltransferase activity
DGN11_RS09495	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGN11_RS09505	COG2095	MarC family integral membrane protein
DGN11_RS09515	COG1611	Belongs to the LOG family
DGN11_RS09560	COG3328	transposase activity
DGN11_RS09570	COG0556	nucleotide-excision repair
DGN11_RS09585	COG3505	Type IV secretory pathway VirD4
DGN11_RS09605	COG2948	multi-organism process
DGN11_RS09625	COG3702	type iv secretory pathway
DGN11_RS09660	COG3328	transposase activity
DGN11_RS09675	COG3328	transposase activity
DGN11_RS09685	COG2190	(PTS) system
DGN11_RS09685	COG2211	Major facilitator Superfamily
DGN11_RS09700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DGN11_RS09705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DGN11_RS09720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DGN11_RS09725	COG0072	phenylalanine-tRNA ligase activity
DGN11_RS09725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN11_RS09775	COG0438	transferase activity, transferring glycosyl groups
DGN11_RS09780	COG0438	transferase activity, transferring glycosyl groups
DGN11_RS09790	COG0438	transferase activity, transferring glycosyl groups
DGN11_RS09815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN11_RS09820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN11_RS09825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN11_RS09845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DGN11_RS09855	COG1960	acyl-CoA dehydrogenase activity
DGN11_RS09865	COG3040	lipid binding
DGN11_RS09875	COG0582	viral genome integration into host DNA
DGN11_RS09885	COG3039	Transposase
DGN11_RS09905	COG3039	Transposase
DGN11_RS09920	COG0322	excinuclease ABC activity
DGN11_RS09935	COG0784	Response regulator, receiver
DGN11_RS09935	COG4191	Histidine kinase
DGN11_RS09940	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DGN11_RS09945	COG1194	a g-specific adenine glycosylase
DGN11_RS09950	COG0552	protein localization to endoplasmic reticulum
DGN11_RS09960	COG3938	Belongs to the proline racemase family
DGN11_RS09965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN11_RS09980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGN11_RS09990	COG0006	proline dipeptidase activity
DGN11_RS10005	COG0531	amino acid
DGN11_RS10090	COG3039	Transposase
DGN11_RS10100	COG3039	Transposase
DGN11_RS10105	COG0326	Molecular chaperone. Has ATPase activity
DGN11_RS10110	COG0742	ribosomal rna small subunit methyltransferase
DGN11_RS10115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DGN11_RS10125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DGN11_RS10130	COG0405	Gamma-glutamyltransferase
DGN11_RS10135	COG3291	Pkd domain containing protein
DGN11_RS10140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DGN11_RS10175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DGN11_RS10180	COG0343	queuine tRNA-ribosyltransferase activity
DGN11_RS10185	COG1862	Preprotein translocase
DGN11_RS10195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DGN11_RS10215	COG3328	transposase activity
DGN11_RS10230	COG3328	transposase activity
DGN11_RS10265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGN11_RS10265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGN11_RS10270	COG1105	Belongs to the carbohydrate kinase PfkB family
DGN11_RS10275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN11_RS10275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGN11_RS10280	COG1609	Transcriptional regulator
DGN11_RS10285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN11_RS10290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN11_RS10300	COG2902	Dehydrogenase
DGN11_RS10310	COG3321	synthase
DGN11_RS10310	COG0604	alcohol dehydrogenase
DGN11_RS10320	COG1902	pentaerythritol trinitrate reductase activity
DGN11_RS10330	COG0300	oxidoreductase activity
DGN11_RS10335	COG3039	Transposase
DGN11_RS10340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DGN11_RS10350	COG3951	Flagellar rod assembly protein muramidase FlgJ
DGN11_RS10350	COG1705	Flagellar rod assembly protein muramidase FlgJ
DGN11_RS10355	COG1706	bacterial-type flagellum-dependent cell motility
DGN11_RS10360	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DGN11_RS10370	COG4787	bacterial-type flagellum-dependent cell motility
DGN11_RS10380	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DGN11_RS10385	COG1558	bacterial-type flagellum-dependent cell motility
DGN11_RS10395	COG0835	chemotaxis
DGN11_RS10395	COG0784	Response regulator, receiver
DGN11_RS10420	COG5002	protein histidine kinase activity
DGN11_RS10450	COG2915	High frequency lysogenization protein hflD homolog
DGN11_RS10455	COG0482	sulfurtransferase activity
DGN11_RS10470	COG0542	response to heat
DGN11_RS10480	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DGN11_RS10490	COG0492	ferredoxin-NADP+ reductase activity
DGN11_RS10495	COG1674	ftsk spoiiie
DGN11_RS10505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DGN11_RS10515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DGN11_RS10520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DGN11_RS10525	COG0183	Belongs to the thiolase family
DGN11_RS10530	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGN11_RS10530	COG1024	Enoyl-CoA hydratase
DGN11_RS10545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DGN11_RS10555	COG1426	Protein conserved in bacteria
DGN11_RS10565	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN11_RS10570	COG1160	GTP binding
DGN11_RS10575	COG0303	'Molybdopterin
DGN11_RS10580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DGN11_RS10615	COG0708	Exodeoxyribonuclease III
DGN11_RS10625	COG0303	'Molybdopterin
DGN11_RS10630	COG0746	molybdenum cofactor guanylyltransferase activity
DGN11_RS10660	COG1914	H( )-stimulated, divalent metal cation uptake system
DGN11_RS10675	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DGN11_RS10680	COG0668	transmembrane transport
DGN11_RS10690	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DGN11_RS10705	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS10710	COG1183	phosphatidylcholine synthase activity
DGN11_RS10720	COG3243	poly(R)-hydroxyalkanoic acid synthase
DGN11_RS10735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN11_RS10735	COG0723	plastoquinol--plastocyanin reductase activity
DGN11_RS10745	COG2183	response to ionizing radiation
DGN11_RS10750	COG0784	Response regulator, receiver
DGN11_RS10750	COG2205	protein histidine kinase activity
DGN11_RS10815	COG0800	Aldolase
DGN11_RS10820	COG0129	dihydroxy-acid dehydratase activity
DGN11_RS10825	COG0363	glucosamine-6-phosphate deaminase activity
DGN11_RS10830	COG0837	glucose binding
DGN11_RS10835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGN11_RS10845	COG0354	folic acid binding
DGN11_RS10860	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DGN11_RS10875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DGN11_RS10880	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DGN11_RS10890	COG4591	ABC-type transport system involved in lipoprotein release permease component
DGN11_RS10895	COG1136	(ABC) transporter
DGN11_RS10910	COG0811	peptide transport
DGN11_RS10915	COG0848	biopolymer transport protein
DGN11_RS10920	COG1132	(ABC) transporter
DGN11_RS10925	COG1663	tetraacyldisaccharide 4'-kinase activity
DGN11_RS10930	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DGN11_RS10935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DGN11_RS10945	COG0322	excinuclease ABC activity
DGN11_RS10950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGN11_RS10975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DGN11_RS10995	COG1054	Belongs to the UPF0176 family
DGN11_RS11005	COG1530	ribonuclease E activity
DGN11_RS11015	COG3064	Membrane
DGN11_RS11020	COG0428	transporter
DGN11_RS11030	COG2154	pterin-4-alpha-carbinolamine dehydratase
DGN11_RS11035	COG0316	Belongs to the HesB IscA family
DGN11_RS11035	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DGN11_RS11085	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGN11_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS11120	COG3328	transposase activity
DGN11_RS11130	COG1136	(ABC) transporter
DGN11_RS11135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGN11_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS11140	COG3321	synthase
DGN11_RS11140	COG4221	oxidoreductase activity
DGN11_RS11140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN11_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS11215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN11_RS11215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN11_RS11215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN11_RS11215	COG3321	synthase
DGN11_RS11215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN11_RS11215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN11_RS11215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN11_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS11215	COG3321	synthase
DGN11_RS11225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN11_RS11270	COG3039	Transposase
DGN11_RS11280	COG0583	DNA-binding transcription factor activity
DGN11_RS11310	COG3220	belongs to the UPF0276 family
DGN11_RS11330	COG3920	Histidine kinase
DGN11_RS11370	COG3279	Response regulator of the LytR AlgR family
DGN11_RS11375	COG3275	phosphorelay sensor kinase activity
DGN11_RS11410	COG4566	intracellular signal transduction
DGN11_RS11425	COG5001	Diguanylate cyclase
DGN11_RS11445	COG3685	Protein conserved in bacteria
DGN11_RS11460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGN11_RS11460	COG1648	precorrin-2 dehydrogenase activity
DGN11_RS11475	COG2814	Major facilitator Superfamily
DGN11_RS11490	COG1335	isochorismatase
DGN11_RS11505	COG2197	response regulator
DGN11_RS11520	COG0583	DNA-binding transcription factor activity
DGN11_RS11525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGN11_RS11535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGN11_RS11535	COG0519	Catalyzes the synthesis of GMP from XMP
DGN11_RS11545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DGN11_RS11555	COG0475	glutathione-regulated potassium exporter activity
DGN11_RS11555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGN11_RS11560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DGN11_RS11570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGN11_RS11575	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DGN11_RS11585	COG0776	regulation of translation
DGN11_RS11590	COG0539	negative regulation of cytoplasmic translation
DGN11_RS11595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DGN11_RS11610	COG2957	Belongs to the agmatine deiminase family
DGN11_RS11615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGN11_RS11640	COG0395	ABC-type sugar transport system, permease component
DGN11_RS11645	COG1175	transmembrane transport
DGN11_RS11675	COG2350	Protein conserved in bacteria
DGN11_RS11680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DGN11_RS11685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DGN11_RS11690	COG1187	pseudouridine synthase activity
DGN11_RS11710	COG0436	Aminotransferase
DGN11_RS11715	COG4133	protoheme IX ABC transporter activity
DGN11_RS11735	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGN11_RS11740	COG1138	Cytochrome C-type biogenesis protein
DGN11_RS11760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN11_RS11765	COG1278	Cold shock
DGN11_RS11770	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DGN11_RS11785	COG1294	oxidase, subunit
DGN11_RS11815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DGN11_RS11820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DGN11_RS11830	COG0165	Argininosuccinate lyase
DGN11_RS11835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DGN11_RS11845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DGN11_RS11850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGN11_RS11860	COG0137	argininosuccinate synthase activity
DGN11_RS11865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DGN11_RS11875	COG0215	cysteine-tRNA ligase activity
DGN11_RS11880	COG2166	iron-sulfur cluster assembly
DGN11_RS11895	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DGN11_RS11900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DGN11_RS11920	COG4302	ethanolamine ammonia-lyase activity
DGN11_RS11960	COG2801	Transposase and inactivated derivatives
DGN11_RS11985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DGN11_RS11990	COG0402	S-adenosylhomocysteine deaminase activity
DGN11_RS12000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGN11_RS12005	COG1509	lysine 2,3-aminomutase activity
DGN11_RS12010	COG3300	MHYT domain
DGN11_RS12010	COG5001	Diguanylate cyclase
DGN11_RS12025	COG0483	inositol monophosphate 1-phosphatase activity
DGN11_RS12030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DGN11_RS12045	COG0488	(ABC) transporter
DGN11_RS12050	COG0513	Belongs to the DEAD box helicase family
DGN11_RS12055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DGN11_RS12060	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DGN11_RS12070	COG0625	glutathione transferase activity
DGN11_RS12080	COG4681	YaeQ
DGN11_RS12085	COG2081	HI0933 family
DGN11_RS12095	COG0501	Belongs to the peptidase M48B family
DGN11_RS12100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN11_RS12105	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS12130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DGN11_RS12135	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGN11_RS12140	COG0802	atpase or kinase
DGN11_RS12145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DGN11_RS12145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGN11_RS12150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGN11_RS12155	COG1570	exodeoxyribonuclease VII activity
DGN11_RS12165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGN11_RS12210	COG0835	chemotaxis
DGN11_RS12215	COG0840	transmembrane signaling receptor activity
DGN11_RS12220	COG2094	Belongs to the DNA glycosylase MPG family
DGN11_RS12225	COG1201	RNA secondary structure unwinding
DGN11_RS12245	COG2969	positive regulation of protein catabolic process
DGN11_RS12250	COG0625	glutathione transferase activity
DGN11_RS12255	COG2857	Cytochrome c1
DGN11_RS12260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DGN11_RS12265	COG0723	plastoquinol--plastocyanin reductase activity
DGN11_RS12270	COG0741	lytic transglycosylase activity
DGN11_RS12285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGN11_RS12290	COG1702	phosphate starvation-inducible protein PhoH
DGN11_RS12300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DGN11_RS12310	COG4535	Mg2 and Co2 transporter CorC
DGN11_RS12325	COG1012	belongs to the aldehyde dehydrogenase family
DGN11_RS12330	COG1177	transmembrane transport
DGN11_RS12335	COG1176	ABC-type spermidine putrescine transport system, permease component I
DGN11_RS12365	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DGN11_RS12385	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DGN11_RS12390	COG0174	glutamine synthetase
DGN11_RS12395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN11_RS12405	COG2703	oxygen carrier activity
DGN11_RS12410	COG0477	Major facilitator Superfamily
DGN11_RS12420	COG0243	molybdopterin cofactor binding
DGN11_RS12425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DGN11_RS12430	COG2223	nitrite transmembrane transporter activity
DGN11_RS12435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DGN11_RS12445	COG2733	membrane
DGN11_RS12450	COG2205	protein histidine kinase activity
DGN11_RS12450	COG0784	Response regulator, receiver
DGN11_RS12450	COG5002	protein histidine kinase activity
DGN11_RS12465	COG0477	Major facilitator Superfamily
DGN11_RS12480	COG3039	Transposase
DGN11_RS12495	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DGN11_RS12525	COG2201	protein-glutamate methylesterase activity
DGN11_RS12545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN11_RS12550	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS12555	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS12585	COG3039	Transposase
DGN11_RS12600	COG1677	Flagellar hook-basal body complex protein FliE
DGN11_RS12650	COG3190	flagellar
DGN11_RS12670	COG1684	flagellar biosynthetic protein fliR
DGN11_RS12695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DGN11_RS12725	COG0643	Histidine kinase
DGN11_RS12725	COG0784	Response regulator, receiver
DGN11_RS12725	COG2198	Histidine kinase
DGN11_RS12730	COG3328	transposase activity
DGN11_RS12750	COG3039	Transposase
DGN11_RS12780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DGN11_RS12785	COG1360	Flagellar Motor Protein
DGN11_RS12795	COG0835	chemotaxis
DGN11_RS12805	COG0745	RESPONSE REGULATOR receiver
DGN11_RS12815	COG0840	transmembrane signaling receptor activity
DGN11_RS12830	COG0840	transmembrane signaling receptor activity
DGN11_RS12835	COG0840	transmembrane signaling receptor activity
DGN11_RS12840	COG0840	transmembrane signaling receptor activity
DGN11_RS12845	COG0840	transmembrane signaling receptor activity
DGN11_RS12855	COG0840	transmembrane signaling receptor activity
DGN11_RS12860	COG0840	transmembrane signaling receptor activity
DGN11_RS12865	COG0840	transmembrane signaling receptor activity
DGN11_RS12870	COG0840	transmembrane signaling receptor activity
DGN11_RS12890	COG0835	chemotaxis
DGN11_RS12905	COG0840	transmembrane signaling receptor activity
DGN11_RS12915	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DGN11_RS12920	COG2201	protein-glutamate methylesterase activity
DGN11_RS12930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN11_RS12955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DGN11_RS12965	COG0318	PFAM AMP-dependent synthetase and ligase
DGN11_RS12970	COG1024	Enoyl-CoA hydratase
DGN11_RS12975	COG2198	Histidine kinase
DGN11_RS12975	COG0784	Response regulator, receiver
DGN11_RS12975	COG2205	protein histidine kinase activity
DGN11_RS12980	COG0784	Response regulator, receiver
DGN11_RS12980	COG2198	Histidine kinase
DGN11_RS12980	COG2205	protein histidine kinase activity
DGN11_RS12990	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DGN11_RS13000	COG3279	Response regulator of the LytR AlgR family
DGN11_RS13010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DGN11_RS13020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN11_RS13025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DGN11_RS13035	COG0505	Belongs to the CarA family
DGN11_RS13040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DGN11_RS13045	COG2258	MOSC domain
DGN11_RS13050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGN11_RS13095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGN11_RS13115	COG0277	FAD linked oxidase domain protein
DGN11_RS13120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DGN11_RS13130	COG0531	amino acid
DGN11_RS13135	COG0531	amino acid
DGN11_RS13140	COG0235	Class ii aldolase
DGN11_RS13145	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DGN11_RS13150	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DGN11_RS13165	COG0140	phosphoribosyl-ATP diphosphatase activity
DGN11_RS13165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DGN11_RS13170	COG0107	imidazoleglycerol-phosphate synthase activity
DGN11_RS13175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DGN11_RS13180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DGN11_RS13185	COG0131	Imidazoleglycerol-phosphate dehydratase
DGN11_RS13185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DGN11_RS13190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN11_RS13195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DGN11_RS13200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DGN11_RS13210	COG0124	histidyl-tRNA synthetase
DGN11_RS13215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN11_RS13260	COG3328	transposase activity
DGN11_RS13270	COG2801	Transposase and inactivated derivatives
DGN11_RS13280	COG3039	Transposase
DGN11_RS13290	COG3039	Transposase
DGN11_RS13295	COG3039	Transposase
DGN11_RS13335	COG0726	polysaccharide deacetylase
DGN11_RS13335	COG1649	PFAM Uncharacterised BCR, COG1649
DGN11_RS13340	COG1215	transferase activity, transferring glycosyl groups
DGN11_RS13355	COG1012	belongs to the aldehyde dehydrogenase family
DGN11_RS13370	COG0167	dihydroorotate dehydrogenase activity
DGN11_RS13375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DGN11_RS13380	COG0697	spore germination
DGN11_RS13385	COG1794	racemase activity, acting on amino acids and derivatives
DGN11_RS13405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DGN11_RS13415	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DGN11_RS13420	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN11_RS13425	COG5001	Diguanylate cyclase
DGN11_RS13425	COG3706	GGDEF domain
DGN11_RS13425	COG2203	Gaf domain
DGN11_RS13425	COG4251	negative regulation of phosphorylation
DGN11_RS13435	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN11_RS13460	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DGN11_RS13465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DGN11_RS13470	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DGN11_RS13490	COG1469	GTP cyclohydrolase I activity
DGN11_RS13495	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGN11_RS13505	COG3328	transposase activity
DGN11_RS13525	COG2115	Belongs to the xylose isomerase family
DGN11_RS13530	COG1070	Carbohydrate kinase
DGN11_RS13540	COG1501	Belongs to the glycosyl hydrolase 31 family
DGN11_RS13575	COG0800	Aldolase
DGN11_RS13580	COG4948	Mandelate Racemase Muconate Lactonizing
DGN11_RS13590	COG3734	2-keto-3-deoxy-galactonokinase
DGN11_RS13595	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DGN11_RS13605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGN11_RS13620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DGN11_RS13625	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DGN11_RS13640	COG0351	phosphomethylpyrimidine kinase
DGN11_RS13665	COG0583	DNA-binding transcription factor activity
DGN11_RS13670	COG1741	Belongs to the pirin family
DGN11_RS13685	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DGN11_RS13690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DGN11_RS13695	COG2137	regulation of response to DNA damage stimulus
DGN11_RS13700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DGN11_RS13705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGN11_RS13715	COG1546	Belongs to the CinA family
DGN11_RS13720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DGN11_RS13730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DGN11_RS13735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DGN11_RS13745	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DGN11_RS13750	COG1534	Rna-binding protein
DGN11_RS13765	COG1238	metal cluster binding
DGN11_RS13770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGN11_RS13775	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DGN11_RS13780	COG2840	Smr protein MutS2
DGN11_RS13785	COG0585	pseudouridine synthase activity
DGN11_RS13790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DGN11_RS13795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DGN11_RS13800	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DGN11_RS13805	COG0148	phosphopyruvate hydratase activity
DGN11_RS13820	COG0504	CTP synthase activity
DGN11_RS13845	COG0306	phosphate transporter
DGN11_RS13855	COG1253	flavin adenine dinucleotide binding
DGN11_RS13880	COG0477	Major facilitator Superfamily
DGN11_RS13890	COG1136	(ABC) transporter
DGN11_RS13915	COG2264	protein methyltransferase activity
DGN11_RS13945	COG2244	polysaccharide biosynthetic process
DGN11_RS13995	COG1595	DNA-templated transcription, initiation
DGN11_RS14010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGN11_RS14020	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGN11_RS14030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN11_RS14045	COG0784	Response regulator, receiver
DGN11_RS14045	COG4191	Histidine kinase
DGN11_RS14050	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DGN11_RS14075	COG0840	transmembrane signaling receptor activity
DGN11_RS14095	COG3328	transposase activity
DGN11_RS14115	COG0583	DNA-binding transcription factor activity
DGN11_RS14120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DGN11_RS14125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DGN11_RS14140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DGN11_RS14145	COG0077	Prephenate dehydratase
DGN11_RS14145	COG1605	Chorismate mutase
DGN11_RS14150	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DGN11_RS14155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DGN11_RS14160	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DGN11_RS14195	COG1228	amidohydrolase
DGN11_RS14200	COG2986	histidine ammonia-lyase
DGN11_RS14210	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DGN11_RS14220	COG4993	Dehydrogenase
DGN11_RS14230	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DGN11_RS14240	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DGN11_RS14245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DGN11_RS14250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN11_RS14260	COG3115	cell septum assembly
DGN11_RS14275	COG0359	binds to the 23S rRNA
DGN11_RS14280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DGN11_RS14285	COG0360	Binds together with S18 to 16S ribosomal RNA
DGN11_RS14290	COG0316	Belongs to the HesB IscA family
DGN11_RS14295	COG0017	Asparaginyl-tRNA synthetase
DGN11_RS14330	COG3039	Transposase
DGN11_RS14380	COG0288	reversible hydration of carbon dioxide
DGN11_RS14385	COG0662	Cupin 2, conserved barrel domain protein
DGN11_RS14395	COG3844	kynureninase activity
DGN11_RS14400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN11_RS14405	COG2925	Exonuclease
DGN11_RS14430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DGN11_RS14435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGN11_RS14435	COG0116	Belongs to the methyltransferase superfamily
DGN11_RS14445	COG0488	(ABC) transporter
DGN11_RS14480	COG0494	nUDIX hydrolase
DGN11_RS14490	COG1024	Enoyl-CoA hydratase
DGN11_RS14500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DGN11_RS14505	COG0659	secondary active sulfate transmembrane transporter activity
DGN11_RS14530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DGN11_RS14535	COG0573	inorganic phosphate transmembrane transporter activity
DGN11_RS14540	COG0581	inorganic phosphate transmembrane transporter activity
DGN11_RS14545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DGN11_RS14550	COG0704	Plays a role in the regulation of phosphate uptake
DGN11_RS14560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGN11_RS14570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGN11_RS14580	COG0557	exoribonuclease II activity
DGN11_RS14605	COG1960	acyl-CoA dehydrogenase activity
DGN11_RS14610	COG2226	methyltransferase
DGN11_RS14615	COG0646	methionine synthase
DGN11_RS14615	COG1410	methionine synthase
DGN11_RS14620	COG0646	methionine synthase
DGN11_RS14620	COG1410	methionine synthase
DGN11_RS14630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN11_RS14655	COG2900	Belongs to the SlyX family
DGN11_RS14670	COG0386	Belongs to the glutathione peroxidase family
DGN11_RS14680	COG1725	Transcriptional regulator
DGN11_RS14685	COG1131	(ABC) transporter
DGN11_RS14715	COG1253	flavin adenine dinucleotide binding
DGN11_RS14735	COG2850	peptidyl-arginine hydroxylation
DGN11_RS14745	COG0567	Dehydrogenase, E1 component
DGN11_RS14770	COG1132	(ABC) transporter
DGN11_RS14775	COG0583	DNA-binding transcription factor activity
DGN11_RS14805	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DGN11_RS14810	COG0484	heat shock protein binding
DGN11_RS14815	COG0443	Heat shock 70 kDa protein
DGN11_RS14820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DGN11_RS14825	COG1420	regulation of RNA biosynthetic process
DGN11_RS14830	COG0497	DNA recombination
DGN11_RS14840	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN11_RS14855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DGN11_RS14870	COG0582	viral genome integration into host DNA
DGN11_RS14875	COG3328	transposase activity
DGN11_RS14885	COG3706	GGDEF domain
DGN11_RS14930	COG0583	DNA-binding transcription factor activity
DGN11_RS14940	COG0415	Belongs to the DNA photolyase family
DGN11_RS14945	COG0305	Participates in initiation and elongation during chromosome replication
DGN11_RS14955	COG0367	asparagine synthase
DGN11_RS14970	COG1960	acyl-CoA dehydrogenase activity
DGN11_RS14985	COG0084	hydrolase, TatD family'
DGN11_RS14990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DGN11_RS15045	COG0386	Belongs to the glutathione peroxidase family
DGN11_RS15050	COG0339	signal peptide processing
DGN11_RS15100	COG2814	Major facilitator Superfamily
DGN11_RS15105	COG1566	PFAM secretion protein HlyD family protein
DGN11_RS15130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DGN11_RS15145	COG4774	siderophore transport
DGN11_RS15155	COG0367	asparagine synthase
DGN11_RS15160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGN11_RS15165	COG1393	Belongs to the ArsC family
DGN11_RS15175	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DGN11_RS15215	COG0052	Belongs to the universal ribosomal protein uS2 family
DGN11_RS15220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DGN11_RS15230	COG0528	UMP kinase activity
DGN11_RS15235	COG0233	cytoplasmic translational termination
DGN11_RS15240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DGN11_RS15245	COG0575	Belongs to the CDS family
DGN11_RS15250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DGN11_RS15255	COG0750	zinc metalloprotease
DGN11_RS15270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN11_RS15275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGN11_RS15280	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN11_RS15285	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN11_RS15300	COG0825	malonyl-CoA metabolic process
DGN11_RS15315	COG1981	membrane
DGN11_RS15335	COG1695	Transcriptional regulator
DGN11_RS15355	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGN11_RS15365	COG2040	homocysteine
DGN11_RS15370	COG0833	amino acid
DGN11_RS15375	COG0346	lactoylglutathione lyase activity
DGN11_RS15380	COG1131	(ABC) transporter
DGN11_RS15390	COG3039	Transposase
DGN11_RS15405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN11_RS15405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN11_RS15415	COG2878	Part of a membrane complex involved in electron transport
DGN11_RS15430	COG1595	DNA-templated transcription, initiation
DGN11_RS15455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGN11_RS15470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGN11_RS15475	COG0251	oxidation-reduction process
DGN11_RS15485	COG0392	lysyltransferase activity
DGN11_RS15485	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DGN11_RS15520	COG2814	Major facilitator Superfamily
DGN11_RS15525	COG1902	pentaerythritol trinitrate reductase activity
DGN11_RS15530	COG2824	Alkylphosphonate utilization operon protein PhnA
DGN11_RS15540	COG1047	Peptidyl-prolyl cis-trans
DGN11_RS15545	COG1077	Cell shape determining protein MreB Mrl
DGN11_RS15560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DGN11_RS15570	COG5487	UPF0391 membrane protein
DGN11_RS15575	COG1451	nucleotide metabolic process
DGN11_RS15600	COG0183	Belongs to the thiolase family
DGN11_RS15630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DGN11_RS15630	COG1793	dna ligase
DGN11_RS15640	COG1793	dna ligase
DGN11_RS15645	COG1201	RNA secondary structure unwinding
DGN11_RS15655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN11_RS15660	COG1278	Cold shock
DGN11_RS15665	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DGN11_RS15670	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DGN11_RS15675	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN11_RS15680	COG3046	protein related to deoxyribodipyrimidine photolyase
DGN11_RS15685	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DGN11_RS15690	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DGN11_RS15695	COG2954	triphosphatase activity
DGN11_RS15700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DGN11_RS15710	COG1381	Involved in DNA repair and RecF pathway recombination
DGN11_RS15715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DGN11_RS15720	COG0571	ribonuclease III activity
DGN11_RS15735	COG0481	GTPase activity
DGN11_RS15740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGN11_RS15755	COG1024	Enoyl-CoA hydratase
DGN11_RS15755	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGN11_RS15765	COG2801	Transposase and inactivated derivatives
DGN11_RS15775	COG3039	Transposase
DGN11_RS15800	COG1024	Enoyl-CoA hydratase
DGN11_RS15805	COG1960	acyl-CoA dehydrogenase activity
DGN11_RS15825	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DGN11_RS15830	COG3250	beta-galactosidase activity
DGN11_RS15855	COG3328	transposase activity
DGN11_RS15865	COG3039	Transposase
DGN11_RS15875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DGN11_RS15885	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DGN11_RS15905	COG0534	Mate efflux family protein
DGN11_RS15910	COG0335	large ribosomal subunit rRNA binding
DGN11_RS15915	COG0336	Belongs to the RNA methyltransferase TrmD family
DGN11_RS15920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DGN11_RS15925	COG0228	four-way junction DNA binding
DGN11_RS15940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DGN11_RS15945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGN11_RS15975	COG0784	Response regulator, receiver
DGN11_RS15975	COG4191	Histidine kinase
DGN11_RS15980	COG2205	protein histidine kinase activity
DGN11_RS15980	COG3850	Histidine kinase
DGN11_RS15980	COG3437	response regulator, receiver
DGN11_RS15980	COG4999	Histidine kinase
DGN11_RS15985	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGN11_RS15995	COG2205	protein histidine kinase activity
DGN11_RS16000	COG5507	3-demethylubiquinone-9 3-methyltransferase
DGN11_RS16010	COG4771	TonB-dependent receptor
DGN11_RS16035	COG2172	sigma factor antagonist activity
DGN11_RS16040	COG1366	Belongs to the anti-sigma-factor antagonist family
DGN11_RS16045	COG1366	Belongs to the anti-sigma-factor antagonist family
DGN11_RS16055	COG0326	Molecular chaperone. Has ATPase activity
DGN11_RS16060	COG2207	Transcriptional regulator
DGN11_RS16070	COG3152	Membrane
DGN11_RS16085	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DGN11_RS16090	COG1845	cytochrome c oxidase, subunit III
DGN11_RS16095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DGN11_RS16120	COG3328	transposase activity
DGN11_RS16125	COG3328	transposase activity
DGN11_RS16180	COG2022	thiamine diphosphate biosynthetic process
DGN11_RS16185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DGN11_RS16190	COG0471	metal ion transport
DGN11_RS16190	COG3273	potassium ion transport
DGN11_RS16210	COG1970	mechanosensitive ion channel activity
DGN11_RS16220	COG1609	Transcriptional regulator
DGN11_RS16230	COG3250	beta-galactosidase activity
DGN11_RS16235	COG4948	Mandelate Racemase Muconate Lactonizing
DGN11_RS16245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGN11_RS16255	COG0308	aminopeptidase N
DGN11_RS16260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN11_RS16265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN11_RS16270	COG0529	Catalyzes the synthesis of activated sulfate
DGN11_RS16270	COG2895	sulfate adenylyltransferase (ATP) activity
DGN11_RS16275	COG0175	sulfate reduction
DGN11_RS16280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN11_RS16285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DGN11_RS16290	COG0175	sulfate reduction
DGN11_RS16310	COG3039	Transposase
DGN11_RS16330	COG2205	protein histidine kinase activity
DGN11_RS16330	COG2198	Histidine kinase
DGN11_RS16330	COG0784	Response regulator, receiver
DGN11_RS16345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGN11_RS16345	COG1648	precorrin-2 dehydrogenase activity
DGN11_RS16360	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DGN11_RS16365	COG3588	fructose-bisphosphate aldolase
DGN11_RS16370	COG0469	pyruvate kinase activity
DGN11_RS16380	COG0126	phosphoglycerate kinase activity
DGN11_RS16400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DGN11_RS16410	COG3047	cAMP biosynthetic process
DGN11_RS16415	COG3047	cAMP biosynthetic process
DGN11_RS16425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN11_RS16425	COG3453	Protein conserved in bacteria
DGN11_RS16430	COG0725	ABC transporter, periplasmic molybdate-binding protein
DGN11_RS16435	COG4149	molybdate abc transporter
DGN11_RS16440	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DGN11_RS16475	COG1376	ErfK ybiS ycfS ynhG family protein
DGN11_RS16480	COG0739	heme binding
DGN11_RS16485	COG4773	Receptor
DGN11_RS16495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DGN11_RS16500	COG1301	dicarboxylic acid transport
DGN11_RS16505	COG3039	Transposase
DGN11_RS16515	COG2304	oxidoreductase activity
DGN11_RS16535	COG0714	Associated with various cellular activities
DGN11_RS16565	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DGN11_RS16590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DGN11_RS16600	COG2721	sulfolactate sulfo-lyase activity
DGN11_RS16615	COG2271	Major facilitator Superfamily
DGN11_RS16630	COG0583	DNA-binding transcription factor activity
DGN11_RS16635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGN11_RS16650	COG1561	YicC-like family, N-terminal region
DGN11_RS16655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DGN11_RS16665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DGN11_RS16670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DGN11_RS16685	COG0006	proline dipeptidase activity
DGN11_RS16695	COG0006	proline dipeptidase activity
DGN11_RS16700	COG3079	Belongs to the UPF0149 family
DGN11_RS16720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DGN11_RS16730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DGN11_RS16740	COG2912	Transglutaminase-like superfamily
DGN11_RS16745	COG1773	rubredoxin
DGN11_RS16750	COG0352	thiamine-phosphate diphosphorylase activity
DGN11_RS16765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DGN11_RS16780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN11_RS16810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DGN11_RS16815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN11_RS16820	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS16830	COG0671	phosphoesterase, PA-phosphatase related
DGN11_RS16835	COG3781	membrane
DGN11_RS16845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGN11_RS16850	COG0563	adenylate kinase activity
DGN11_RS16865	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DGN11_RS16875	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DGN11_RS16900	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DGN11_RS16910	COG0840	transmembrane signaling receptor activity
DGN11_RS16915	COG0405	Gamma-glutamyltransferase
DGN11_RS16920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DGN11_RS16940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DGN11_RS16945	COG0473	3-isopropylmalate dehydrogenase activity
DGN11_RS16950	COG0066	3-isopropylmalate dehydratase activity
DGN11_RS16955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DGN11_RS16975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGN11_RS16980	COG1538	Outer membrane efflux protein
DGN11_RS16985	COG1519	Transferase
DGN11_RS16990	COG1560	Kdo2-lipid A biosynthetic process
DGN11_RS17015	COG0281	malic enzyme
DGN11_RS17015	COG0280	phosphate acetyltransferase
DGN11_RS17020	COG1301	dicarboxylic acid transport
DGN11_RS17035	COG3039	Transposase
DGN11_RS17050	COG0583	DNA-binding transcription factor activity
DGN11_RS17055	COG0667	Aldo Keto reductase
DGN11_RS17070	COG2197	response regulator
DGN11_RS17080	COG0642	Histidine kinase
DGN11_RS17095	COG2851	Citrate transporter
DGN11_RS17100	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS17105	COG1609	Transcriptional regulator
DGN11_RS17110	COG2211	Major facilitator Superfamily
DGN11_RS17140	COG1162	GTPase activity
DGN11_RS17145	COG0436	Aminotransferase
DGN11_RS17160	COG0726	polysaccharide deacetylase
DGN11_RS17165	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGN11_RS17180	COG3964	amidohydrolase
DGN11_RS17185	COG0402	S-adenosylhomocysteine deaminase activity
DGN11_RS17205	COG3039	Transposase
DGN11_RS17210	COG1307	EDD domain protein, DegV family
DGN11_RS17215	COG0242	peptide deformylase activity
DGN11_RS17235	COG0457	Tetratricopeptide repeat
DGN11_RS17240	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DGN11_RS17245	COG1215	transferase activity, transferring glycosyl groups
DGN11_RS17250	COG1215	transferase activity, transferring glycosyl groups
DGN11_RS17265	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DGN11_RS17310	COG2188	Transcriptional regulator
DGN11_RS17320	COG1450	Type ii and iii secretion system protein
DGN11_RS17335	COG3166	PFAM Fimbrial assembly family protein
DGN11_RS17340	COG3156	type II secretion system protein K
DGN11_RS17345	COG4795	General secretion pathway protein
DGN11_RS17350	COG2165	general secretion pathway protein
DGN11_RS17355	COG4970	Tfp pilus assembly protein FimT
DGN11_RS17360	COG2165	general secretion pathway protein
DGN11_RS17365	COG1459	type II secretion system
DGN11_RS17370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGN11_RS17375	COG1404	Belongs to the peptidase S8 family
DGN11_RS17380	COG5295	Hep Hag repeat protein
DGN11_RS17385	COG1404	Belongs to the peptidase S8 family
DGN11_RS17390	COG5295	Hep Hag repeat protein
DGN11_RS17395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DGN11_RS17395	COG0047	phosphoribosylformylglycinamidine synthase activity
DGN11_RS17400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGN11_RS17405	COG4974	Belongs to the 'phage' integrase family
DGN11_RS17420	COG0795	lipopolysaccharide-transporting ATPase activity
DGN11_RS17430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGN11_RS17445	COG0525	valine-tRNA ligase activity
DGN11_RS17480	COG1183	phosphatidylcholine synthase activity
DGN11_RS17490	COG0442	prolyl-tRNA aminoacylation
DGN11_RS17505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGN11_RS17510	COG1127	ABC transporter
DGN11_RS17515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGN11_RS17515	COG3218	ABC-type transport auxiliary lipoprotein component
DGN11_RS17545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGN11_RS17550	COG0662	Cupin 2, conserved barrel domain protein
DGN11_RS17550	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DGN11_RS17580	COG2086	electron transfer activity
DGN11_RS17595	COG0463	Glycosyl transferase, family 2
DGN11_RS17615	COG2813	Specifically methylates the guanine in position
DGN11_RS17635	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DGN11_RS17640	COG0438	transferase activity, transferring glycosyl groups
DGN11_RS17660	COG0438	transferase activity, transferring glycosyl groups
DGN11_RS17665	COG0626	cystathionine gamma-synthase activity
DGN11_RS17695	COG0625	glutathione transferase activity
DGN11_RS17705	COG0513	Belongs to the DEAD box helicase family
DGN11_RS17715	COG4771	TonB-dependent receptor
DGN11_RS17720	COG0720	synthase
DGN11_RS17745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DGN11_RS17750	COG1956	GAF domain-containing protein
DGN11_RS17760	COG2819	hydrolase of the alpha beta superfamily
DGN11_RS17770	COG0546	phosphoglycolate phosphatase activity
DGN11_RS17775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DGN11_RS17780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGN11_RS17795	COG0339	signal peptide processing
DGN11_RS17845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGN11_RS17850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN11_RS17855	COG1136	(ABC) transporter
DGN11_RS17860	COG0577	efflux transmembrane transporter activity
DGN11_RS17865	COG0577	efflux transmembrane transporter activity
DGN11_RS17865	COG1136	(ABC) transporter
DGN11_RS17880	COG4191	Histidine kinase
DGN11_RS17885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DGN11_RS17900	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DGN11_RS17905	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DGN11_RS17910	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DGN11_RS17915	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DGN11_RS17920	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DGN11_RS17925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DGN11_RS17935	COG0356	it plays a direct role in the translocation of protons across the membrane
DGN11_RS17955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGN11_RS17965	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGN11_RS18000	COG2011	ABC-type metal ion transport system permease component
DGN11_RS18005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DGN11_RS18010	COG0697	spore germination
DGN11_RS18015	COG1666	GTP binding
DGN11_RS18025	COG5002	protein histidine kinase activity
DGN11_RS18025	COG0784	Response regulator, receiver
DGN11_RS18025	COG2198	Histidine kinase
DGN11_RS18050	COG1187	pseudouridine synthase activity
DGN11_RS18055	COG2813	Specifically methylates the guanine in position
DGN11_RS18075	COG2205	protein histidine kinase activity
DGN11_RS18075	COG2202	Pas domain
DGN11_RS18095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DGN11_RS18100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN11_RS18155	COG0842	Transport permease protein
DGN11_RS18160	COG1131	(ABC) transporter
DGN11_RS18165	COG0025	NhaP-type Na H and K H
DGN11_RS18170	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DGN11_RS18175	COG1573	uracil-dna glycosylase
DGN11_RS18185	COG3384	dioxygenase
DGN11_RS18195	COG0583	DNA-binding transcription factor activity
DGN11_RS18205	COG0667	Aldo Keto reductase
DGN11_RS18215	COG3590	peptidase
DGN11_RS18230	COG0531	amino acid
DGN11_RS18245	COG2972	Histidine kinase
DGN11_RS18260	COG3685	Protein conserved in bacteria
DGN11_RS18265	COG3546	catalase activity
DGN11_RS18300	COG2204	response regulator
DGN11_RS18310	COG1271	oxidase subunit
DGN11_RS18315	COG1294	oxidase, subunit
DGN11_RS18330	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS18335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DGN11_RS18355	COG1132	(ABC) transporter
DGN11_RS18370	COG1063	alcohol dehydrogenase
DGN11_RS18445	COG0251	oxidation-reduction process
DGN11_RS18460	COG0840	transmembrane signaling receptor activity
DGN11_RS18465	COG3328	transposase activity
DGN11_RS18480	COG0583	DNA-binding transcription factor activity
DGN11_RS18485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DGN11_RS18515	COG0659	secondary active sulfate transmembrane transporter activity
DGN11_RS18525	COG0024	Methionine aminopeptidase
DGN11_RS18555	COG3328	transposase activity
DGN11_RS18560	COG0582	viral genome integration into host DNA
DGN11_RS18575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGN11_RS18580	COG1490	D-aminoacyl-tRNA deacylase activity
DGN11_RS18585	COG1560	Kdo2-lipid A biosynthetic process
DGN11_RS18635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DGN11_RS18635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGN11_RS18640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DGN11_RS18645	COG0242	peptide deformylase activity
DGN11_RS18650	COG1652	LysM domain
DGN11_RS18655	COG0758	DNA mediated transformation
DGN11_RS18675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGN11_RS18675	COG1754	DNA topoisomerase type I activity
DGN11_RS18680	COG0009	L-threonylcarbamoyladenylate synthase
DGN11_RS18695	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS18705	COG0616	signal peptide processing
DGN11_RS18710	COG0534	Mate efflux family protein
DGN11_RS18730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DGN11_RS18735	COG0625	glutathione transferase activity
DGN11_RS18750	COG1252	NADH dehydrogenase
DGN11_RS18760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGN11_RS18765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DGN11_RS18770	COG2201	protein-glutamate methylesterase activity
DGN11_RS18775	COG2177	Part of the ABC transporter FtsEX involved in
DGN11_RS18780	COG2884	Cell division ATP-binding protein ftsE
DGN11_RS18785	COG0513	Belongs to the DEAD box helicase family
DGN11_RS18790	COG3118	belongs to the thioredoxin family
DGN11_RS18795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DGN11_RS18800	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DGN11_RS18805	COG0583	DNA-binding transcription factor activity
DGN11_RS18825	COG1652	LysM domain
DGN11_RS18830	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGN11_RS18830	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGN11_RS18835	COG1473	amidohydrolase
DGN11_RS18840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN11_RS18845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN11_RS18865	COG5383	Protein conserved in bacteria
DGN11_RS18905	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DGN11_RS18910	COG3023	N-Acetylmuramoyl-L-alanine amidase
DGN11_RS18920	COG4948	Mandelate Racemase Muconate Lactonizing
DGN11_RS18930	COG0531	amino acid
DGN11_RS18950	COG2133	pyrroloquinoline quinone binding
DGN11_RS18960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DGN11_RS18965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DGN11_RS18975	COG1610	YqeY-like protein
DGN11_RS18980	COG1295	ribonuclease BN
DGN11_RS18985	COG0358	DNA primase activity
DGN11_RS19000	COG0109	protoheme IX farnesyltransferase activity
DGN11_RS19030	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DGN11_RS19045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DGN11_RS19085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DGN11_RS19090	COG0739	heme binding
DGN11_RS19095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DGN11_RS19105	COG2223	nitrite transmembrane transporter activity
DGN11_RS19110	COG0708	Exodeoxyribonuclease III
DGN11_RS19115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DGN11_RS19125	COG1192	Involved in chromosome partitioning
DGN11_RS19130	COG1475	DNA binding
DGN11_RS19145	COG0463	Glycosyl transferase, family 2
DGN11_RS19160	COG0756	dUTP diphosphatase activity
DGN11_RS19165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DGN11_RS19170	COG2003	Belongs to the UPF0758 family
DGN11_RS19175	COG0018	arginyl-trna synthetase
DGN11_RS19190	COG4221	oxidoreductase activity
DGN11_RS19195	COG2755	lipolytic protein G-D-S-L family
DGN11_RS19195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DGN11_RS19210	COG1166	arginine decarboxylase activity
DGN11_RS19215	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DGN11_RS19235	COG3291	Pkd domain containing protein
DGN11_RS19235	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DGN11_RS19250	COG0606	chelatase, subunit chli
DGN11_RS19265	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DGN11_RS19290	COG1690	Belongs to the RtcB family
DGN11_RS19325	COG1090	epimerase
DGN11_RS19335	COG0642	Histidine kinase
DGN11_RS19355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGN11_RS19380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DGN11_RS19385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGN11_RS19395	COG3328	transposase activity
DGN11_RS19400	COG0753	catalase activity
DGN11_RS19415	COG2197	response regulator
DGN11_RS19420	COG4585	Histidine kinase
DGN11_RS19425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN11_RS19430	COG1136	(ABC) transporter
DGN11_RS19455	COG0697	spore germination
DGN11_RS19475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN11_RS19480	COG0180	Tryptophanyl-tRNA synthetase
DGN11_RS19485	COG3237	CsbD-like
DGN11_RS19525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DGN11_RS19545	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DGN11_RS19590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGN11_RS19615	COG1199	ATP-dependent helicase activity
DGN11_RS19630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DGN11_RS19700	COG0625	glutathione transferase activity
DGN11_RS19735	COG4555	ABC transporter
DGN11_RS19745	COG1476	TRANSCRIPTIONal
DGN11_RS19765	COG1230	cation diffusion facilitator family transporter
DGN11_RS19775	COG4774	siderophore transport
DGN11_RS19790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN11_RS19795	COG1131	(ABC) transporter
DGN11_RS19800	COG0842	Transport permease protein
DGN11_RS19805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DGN11_RS19835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGN11_RS19840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGN11_RS19850	COG0045	succinate-CoA ligase (ADP-forming) activity
DGN11_RS19850	COG1042	CoA-binding domain protein
DGN11_RS19850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DGN11_RS19855	COG2239	Acts as a magnesium transporter
DGN11_RS19870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGN11_RS19875	COG3387	PFAM Glycoside hydrolase 15-related
DGN11_RS19890	COG3100	YcgL domain-containing protein
DGN11_RS19895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGN11_RS19905	COG0463	Glycosyl transferase, family 2
DGN11_RS19915	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS19965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN11_RS19990	COG1506	peptidase
DGN11_RS19990	COG4946	Tricorn protease homolog
DGN11_RS19990	COG0823	Involved in the tonB-independent uptake of proteins
DGN11_RS20010	COG0408	coproporphyrinogen oxidase activity
DGN11_RS20045	COG0515	serine threonine protein kinase
DGN11_RS20110	COG1595	DNA-templated transcription, initiation
DGN11_RS20160	COG3039	Transposase
DGN11_RS20225	COG0210	DNA helicase
DGN11_RS20235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN11_RS20240	COG0583	DNA-binding transcription factor activity
DGN11_RS20245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGN11_RS20275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN11_RS20295	COG0357	Ribosomal RNA small subunit methyltransferase G
DGN11_RS20300	COG3540	Alkaline phosphatase
DGN11_RS20325	COG0708	Exodeoxyribonuclease III
DGN11_RS20330	COG1940	carbohydrate kinase activity
DGN11_RS20330	COG1846	Transcriptional regulator
DGN11_RS20340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN11_RS20350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DGN11_RS20355	COG3162	membrane
DGN11_RS20365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DGN11_RS20410	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS20415	COG0179	Fumarylacetoacetate (FAA) hydrolase
DGN11_RS20420	COG4948	Mandelate Racemase Muconate Lactonizing
DGN11_RS20425	COG3254	rhamnose metabolic process
DGN11_RS20430	COG0738	Major facilitator superfamily
DGN11_RS20435	COG1414	Transcriptional regulator
DGN11_RS20440	COG1971	Probably functions as a manganese efflux pump
DGN11_RS20445	COG2205	protein histidine kinase activity
DGN11_RS20455	COG3459	Glycosyltransferase 36 associated
DGN11_RS20460	COG2211	Major facilitator Superfamily
DGN11_RS20465	COG3265	gluconokinase activity
DGN11_RS20470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN11_RS20495	COG2911	Protein conserved in bacteria
DGN11_RS20500	COG0729	surface antigen
DGN11_RS20510	COG3039	Transposase
DGN11_RS20515	COG3039	Transposase
DGN11_RS20540	COG3039	Transposase
DGN11_RS20560	COG0752	glycyl-tRNA synthetase alpha subunit
DGN11_RS20565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGN11_RS20575	COG0519	Catalyzes the synthesis of GMP from XMP
DGN11_RS20575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGN11_RS20585	COG0805	protein transport
DGN11_RS20590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGN11_RS20595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGN11_RS20605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DGN11_RS20625	COG2974	May be involved in recombination
DGN11_RS20630	COG0037	tRNA processing
DGN11_RS20635	COG2115	Belongs to the xylose isomerase family
DGN11_RS20645	COG3661	Belongs to the glycosyl hydrolase 67 family
DGN11_RS20655	COG4948	Mandelate Racemase Muconate Lactonizing
DGN11_RS20665	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN11_RS20670	COG0246	Mannitol dehydrogenase
DGN11_RS20740	COG3386	PFAM SMP-30 Gluconolaconase
DGN11_RS20750	COG3250	beta-galactosidase activity
DGN11_RS20755	COG1904	glucuronate isomerase
DGN11_RS20775	COG3693	PFAM glycoside hydrolase, family 10
DGN11_RS20790	COG2211	Major facilitator Superfamily
DGN11_RS20825	COG3321	synthase
DGN11_RS20825	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS20825	COG0604	alcohol dehydrogenase
DGN11_RS20830	COG2937	Belongs to the GPAT DAPAT family
DGN11_RS20860	COG0284	orotidine-5'-phosphate decarboxylase activity
DGN11_RS20865	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DGN11_RS20870	COG3132	Protein of unknown function, DUF480
DGN11_RS20885	COG0210	DNA helicase
DGN11_RS20890	COG1435	thymidine kinase activity
DGN11_RS20900	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DGN11_RS20910	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DGN11_RS20940	COG3135	benzoate transporter
DGN11_RS20960	COG0676	glucose-6-phosphate 1-epimerase activity
DGN11_RS20970	COG3012	SEC-C Motif Domain Protein
DGN11_RS20975	COG0730	response to heat
DGN11_RS20995	COG0302	gtp cyclohydrolase
DGN11_RS21020	COG1289	transmembrane transporter activity
DGN11_RS21025	COG0477	Major facilitator Superfamily
DGN11_RS21035	COG0583	DNA-binding transcription factor activity
DGN11_RS21040	COG4221	oxidoreductase activity
DGN11_RS21050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN11_RS21075	COG3328	transposase activity
DGN11_RS21095	COG3328	transposase activity
DGN11_RS21120	COG0564	pseudouridine synthase activity
DGN11_RS21130	COG3039	Transposase
DGN11_RS21140	COG3039	Transposase
DGN11_RS21145	COG3039	Transposase
DGN11_RS21160	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS21185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DGN11_RS21190	COG1074	ATP-dependent DNA helicase activity
DGN11_RS21195	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DGN11_RS21230	COG1127	ABC transporter
DGN11_RS21235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGN11_RS21240	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGN11_RS21255	COG2853	Lipoprotein
DGN11_RS21265	COG0386	Belongs to the glutathione peroxidase family
DGN11_RS21290	COG0625	glutathione transferase activity
DGN11_RS21335	COG3077	Addiction module antitoxin, RelB DinJ family
DGN11_RS21340	COG3041	Addiction module toxin RelE StbE family
DGN11_RS21400	COG0840	transmembrane signaling receptor activity
DGN11_RS21420	COG3328	transposase activity
DGN11_RS21435	COG3537	Alpha-1,2-mannosidase
DGN11_RS21455	COG1929	Belongs to the glycerate kinase type-1 family
DGN11_RS21460	COG2271	Major facilitator Superfamily
DGN11_RS21475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGN11_RS21480	COG0861	Integral membrane protein TerC family
DGN11_RS21490	COG0584	glycerophosphoryl diester phosphodiesterase
DGN11_RS21505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DGN11_RS21515	COG0706	membrane insertase activity
DGN11_RS21520	COG0594	ribonuclease P activity
DGN11_RS21610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DGN11_RS21615	COG4691	Plasmid stability protein
DGN11_RS21620	COG1487	ribonuclease activity
DGN11_RS21635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGN11_RS21650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGN11_RS21830	COG3328	transposase activity
DGN11_RS21915	COG3328	transposase activity
DGN11_RS21920	COG3328	transposase activity
DGN11_RS21935	COG2951	lytic endotransglycosylase activity
DGN11_RS22100	COG3321	synthase
DGN11_RS22100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN11_RS22100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN11_RS22100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN11_RS22100	COG1028	Short-chain dehydrogenase reductase Sdr
DGN11_RS22145	COG2813	Specifically methylates the guanine in position
DGN11_RS22230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)