locus-tag	class	description
DGN16_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DGN16_RS00020	COG0187	DNA topoisomerase II activity
DGN16_RS00030	COG0501	Belongs to the peptidase M48B family
DGN16_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DGN16_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN16_RS00120	COG0793	Belongs to the peptidase S41A family
DGN16_RS00125	COG4942	peptidase
DGN16_RS00135	COG2234	aminopeptidase activity
DGN16_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN16_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN16_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN16_RS00165	COG1064	alcohol dehydrogenase
DGN16_RS00175	COG0493	'glutamate synthase
DGN16_RS00180	COG0067	glutamate synthase
DGN16_RS00180	COG0069	glutamate synthase activity
DGN16_RS00180	COG0070	glutamate synthase
DGN16_RS00255	COG1205	dead DEAH box helicase
DGN16_RS00255	COG1111	helicase
DGN16_RS00260	COG1272	protein, Hemolysin III
DGN16_RS00280	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS00305	COG2249	NAD(P)H dehydrogenase (quinone) activity
DGN16_RS00325	COG3039	Transposase
DGN16_RS00350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGN16_RS00365	COG1125	glycine betaine transport
DGN16_RS00365	COG0517	IMP dehydrogenase activity
DGN16_RS00380	COG1119	ATPase activity
DGN16_RS00390	COG1752	Esterase of the alpha-beta hydrolase superfamily
DGN16_RS00400	COG1522	sequence-specific DNA binding
DGN16_RS00405	COG3186	Phenylalanine-4-hydroxylase
DGN16_RS00415	COG2755	lipolytic protein G-D-S-L family
DGN16_RS00425	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS00430	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DGN16_RS00435	COG1609	Transcriptional regulator
DGN16_RS00440	COG3507	Belongs to the glycosyl hydrolase 43 family
DGN16_RS00455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DGN16_RS00465	COG2755	lipolytic protein G-D-S-L family
DGN16_RS00465	COG0657	acetylesterase activity
DGN16_RS00485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN16_RS00490	COG0366	Alpha amylase catalytic
DGN16_RS00495	COG0366	Alpha amylase catalytic
DGN16_RS00520	COG3039	Transposase
DGN16_RS00545	COG3328	transposase activity
DGN16_RS00550	COG3328	transposase activity
DGN16_RS00575	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DGN16_RS00580	COG3710	Transcriptional regulator
DGN16_RS00600	COG2197	response regulator
DGN16_RS00605	COG4585	Histidine kinase
DGN16_RS00615	COG1304	FMN binding
DGN16_RS00640	COG1012	belongs to the aldehyde dehydrogenase family
DGN16_RS00655	COG4772	TonB-dependent receptor
DGN16_RS00665	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DGN16_RS00695	COG0714	Associated with various cellular activities
DGN16_RS00735	COG0477	Major facilitator Superfamily
DGN16_RS00740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN16_RS00760	COG3039	Transposase
DGN16_RS00790	COG3237	CsbD-like
DGN16_RS00800	COG3039	Transposase
DGN16_RS00810	COG0489	protein tyrosine kinase activity
DGN16_RS00815	COG2062	phosphohistidine phosphatase, SixA
DGN16_RS00825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN16_RS00870	COG1968	undecaprenyl-diphosphatase activity
DGN16_RS00875	COG0174	glutamine synthetase
DGN16_RS00880	COG0347	Belongs to the P(II) protein family
DGN16_RS00885	COG0004	ammonium transporteR
DGN16_RS00895	COG3852	Histidine kinase
DGN16_RS00900	COG2204	response regulator
DGN16_RS00905	COG2032	superoxide dismutase activity
DGN16_RS00910	COG2032	superoxide dismutase activity
DGN16_RS00920	COG3039	Transposase
DGN16_RS00935	COG0183	Belongs to the thiolase family
DGN16_RS00970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DGN16_RS00975	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DGN16_RS00980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DGN16_RS00995	COG0028	Belongs to the TPP enzyme family
DGN16_RS01000	COG2205	protein histidine kinase activity
DGN16_RS01025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DGN16_RS01040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN16_RS01050	COG0596	Alpha beta hydrolase
DGN16_RS01055	COG0727	PFAM Uncharacterised protein family (UPF0153)
DGN16_RS01060	COG0318	PFAM AMP-dependent synthetase and ligase
DGN16_RS01065	COG0745	RESPONSE REGULATOR receiver
DGN16_RS01075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN16_RS01095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGN16_RS01105	COG0564	pseudouridine synthase activity
DGN16_RS01125	COG1446	asparaginase
DGN16_RS01130	COG0339	signal peptide processing
DGN16_RS01165	COG0475	glutathione-regulated potassium exporter activity
DGN16_RS01170	COG0583	DNA-binding transcription factor activity
DGN16_RS01175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DGN16_RS01180	COG2224	Isocitrate lyase
DGN16_RS01195	COG3039	Transposase
DGN16_RS01225	COG4770	biotin carboxylase activity
DGN16_RS01230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DGN16_RS01235	COG1960	acyl-CoA dehydrogenase activity
DGN16_RS01300	COG0697	spore germination
DGN16_RS01310	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DGN16_RS01315	COG1846	Transcriptional regulator
DGN16_RS01320	COG1764	response to oxidative stress
DGN16_RS01345	COG2130	NADP-dependent
DGN16_RS01360	COG1187	pseudouridine synthase activity
DGN16_RS01375	COG1643	Atp-dependent helicase
DGN16_RS01380	COG4807	Protein conserved in bacteria
DGN16_RS01385	COG2351	hydroxyisourate hydrolase activity
DGN16_RS01390	COG2072	flavoprotein involved in K transport
DGN16_RS01410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DGN16_RS01420	COG0583	DNA-binding transcription factor activity
DGN16_RS01455	COG2252	PERMEase
DGN16_RS01495	COG0583	DNA-binding transcription factor activity
DGN16_RS01500	COG2814	Major facilitator Superfamily
DGN16_RS01510	COG2267	carboxylic ester hydrolase activity
DGN16_RS01515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DGN16_RS01520	COG1902	pentaerythritol trinitrate reductase activity
DGN16_RS01540	COG0745	RESPONSE REGULATOR receiver
DGN16_RS01545	COG2205	protein histidine kinase activity
DGN16_RS01550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_RS01570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGN16_RS01575	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGN16_RS01580	COG0583	DNA-binding transcription factor activity
DGN16_RS01610	COG0702	epimerase
DGN16_RS01615	COG1733	regulation of RNA biosynthetic process
DGN16_RS01655	COG3328	transposase activity
DGN16_RS01665	COG3039	Transposase
DGN16_RS01675	COG0129	dihydroxy-acid dehydratase activity
DGN16_RS01690	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DGN16_RS01745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DGN16_RS01750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DGN16_RS01775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DGN16_RS01780	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DGN16_RS01790	COG3485	protocatechuate 3,4-dioxygenase
DGN16_RS01795	COG3485	protocatechuate 3,4-dioxygenase
DGN16_RS01805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN16_RS01810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DGN16_RS01820	COG1414	Transcriptional regulator
DGN16_RS01830	COG0657	acetylesterase activity
DGN16_RS01840	COG0445	tRNA wobble uridine modification
DGN16_RS01850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DGN16_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS01880	COG2267	carboxylic ester hydrolase activity
DGN16_RS01890	COG0156	8-amino-7-oxononanoate synthase activity
DGN16_RS01895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DGN16_RS01900	COG1040	competence protein
DGN16_RS01905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DGN16_RS01940	COG3039	Transposase
DGN16_RS02015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DGN16_RS02100	COG3264	Mechanosensitive ion channel
DGN16_RS02100	COG1511	domain protein
DGN16_RS02105	COG1368	sulfuric ester hydrolase activity
DGN16_RS02110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGN16_RS02125	COG2354	Protein conserved in bacteria
DGN16_RS02135	COG0297	glycogen (starch) synthase activity
DGN16_RS02140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN16_RS02145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN16_RS02170	COG0702	epimerase
DGN16_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS02205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN16_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS02220	COG0513	Belongs to the DEAD box helicase family
DGN16_RS02225	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGN16_RS02240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DGN16_RS02250	COG3483	tryptophan 2,3-dioxygenase activity
DGN16_RS02255	COG3104	oligopeptide transport
DGN16_RS02290	COG1320	monovalent cation:proton antiporter activity
DGN16_RS02295	COG2212	antiporter activity
DGN16_RS02305	COG0651	ATP synthesis coupled electron transport
DGN16_RS02310	COG1006	Multisubunit Na H antiporter MnhC subunit
DGN16_RS02315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGN16_RS02315	COG2111	Na H antiporter
DGN16_RS02340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DGN16_RS02345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DGN16_RS02360	COG0456	acetyltransferase
DGN16_RS02365	COG1597	lipid kinase activity
DGN16_RS02385	COG0582	viral genome integration into host DNA
DGN16_RS02395	COG3039	Transposase
DGN16_RS02410	COG3039	Transposase
DGN16_RS02430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DGN16_RS02435	COG0134	indole-3-glycerol-phosphate synthase activity
DGN16_RS02445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN16_RS02450	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DGN16_RS02460	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DGN16_RS02470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DGN16_RS02485	COG1051	belongs to the nudix hydrolase family
DGN16_RS02525	COG0316	Belongs to the HesB IscA family
DGN16_RS02540	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGN16_RS02555	COG2814	Major facilitator Superfamily
DGN16_RS02565	COG2814	Major facilitator Superfamily
DGN16_RS02570	COG1289	transmembrane transporter activity
DGN16_RS02580	COG0151	Belongs to the GarS family
DGN16_RS02590	COG0138	bifunctional purine biosynthesis protein purh
DGN16_RS02595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGN16_RS02605	COG2453	phosphatase
DGN16_RS02605	COG0671	phosphoesterase, PA-phosphatase related
DGN16_RS02630	COG4589	Belongs to the CDS family
DGN16_RS02635	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DGN16_RS02660	COG2264	protein methyltransferase activity
DGN16_RS02680	COG0439	Biotin carboxylase
DGN16_RS02690	COG0511	ligase activity, forming carbon-carbon bonds
DGN16_RS02695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DGN16_RS02705	COG1324	tolerance protein
DGN16_RS02715	COG2356	endonuclease I
DGN16_RS02725	COG0459	protein refolding
DGN16_RS02740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DGN16_RS02755	COG3386	PFAM SMP-30 Gluconolaconase
DGN16_RS02765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DGN16_RS02770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGN16_RS02795	COG0778	Nitroreductase
DGN16_RS02800	COG2353	YceI-like domain
DGN16_RS02825	COG3052	prosthetic group binding
DGN16_RS02850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGN16_RS02860	COG1802	Transcriptional regulator
DGN16_RS02925	COG3039	Transposase
DGN16_RS02945	COG3039	Transposase
DGN16_RS02985	COG4221	oxidoreductase activity
DGN16_RS03000	COG4221	oxidoreductase activity
DGN16_RS03010	COG0435	Glutathione S-transferase
DGN16_RS03040	COG0823	Involved in the tonB-independent uptake of proteins
DGN16_RS03040	COG1506	peptidase
DGN16_RS03075	COG0697	spore germination
DGN16_RS03080	COG4305	rare lipoprotein A
DGN16_RS03085	COG5297	Belongs to the glycosyl hydrolase family 6
DGN16_RS03095	COG1113	amino acid transport
DGN16_RS03115	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DGN16_RS03160	COG0840	transmembrane signaling receptor activity
DGN16_RS03165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN16_RS03165	COG5297	Belongs to the glycosyl hydrolase family 6
DGN16_RS03170	COG0659	secondary active sulfate transmembrane transporter activity
DGN16_RS03185	COG2943	transferase activity, transferring hexosyl groups
DGN16_RS03195	COG3275	phosphorelay sensor kinase activity
DGN16_RS03205	COG0181	hydroxymethylbilane synthase activity
DGN16_RS03230	COG1505	serine-type exopeptidase activity
DGN16_RS03235	COG0436	Aminotransferase
DGN16_RS03245	COG2832	Protein of unknown function (DUF454)
DGN16_RS03255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DGN16_RS03265	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DGN16_RS03270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DGN16_RS03275	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DGN16_RS03300	COG2226	methyltransferase
DGN16_RS03305	COG3300	MHYT domain
DGN16_RS03305	COG5001	Diguanylate cyclase
DGN16_RS03310	COG0308	aminopeptidase N
DGN16_RS03360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN16_RS03365	COG1077	Cell shape determining protein MreB Mrl
DGN16_RS03370	COG1792	Involved in formation and maintenance of cell shape
DGN16_RS03385	COG0772	Belongs to the SEDS family
DGN16_RS03395	COG2951	lytic endotransglycosylase activity
DGN16_RS03400	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DGN16_RS03405	COG1686	Belongs to the peptidase S11 family
DGN16_RS03415	COG2921	Belongs to the UPF0250 family
DGN16_RS03420	COG0321	lipoyl(octanoyl) transferase activity
DGN16_RS03425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DGN16_RS03450	COG1051	belongs to the nudix hydrolase family
DGN16_RS03450	COG1056	cytidyltransferase-related domain
DGN16_RS03485	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DGN16_RS03490	COG0673	inositol 2-dehydrogenase activity
DGN16_RS03495	COG2823	Periplasmic or secreted lipoprotein
DGN16_RS03500	COG4251	negative regulation of phosphorylation
DGN16_RS03505	COG0784	Response regulator, receiver
DGN16_RS03510	COG4191	Histidine kinase
DGN16_RS03515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DGN16_RS03570	COG1459	type II secretion system
DGN16_RS03575	COG2165	general secretion pathway protein
DGN16_RS03590	COG4795	General secretion pathway protein
DGN16_RS03620	COG3250	beta-galactosidase activity
DGN16_RS03635	COG2188	Transcriptional regulator
DGN16_RS03645	COG1609	Transcriptional regulator
DGN16_RS03650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGN16_RS03655	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DGN16_RS03670	COG0617	tRNA 3'-terminal CCA addition
DGN16_RS03675	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGN16_RS03680	COG1012	belongs to the aldehyde dehydrogenase family
DGN16_RS03685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DGN16_RS03700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGN16_RS03715	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DGN16_RS03735	COG2205	protein histidine kinase activity
DGN16_RS03765	COG3791	Glutathione-dependent formaldehyde-activating
DGN16_RS03780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGN16_RS03800	COG0488	(ABC) transporter
DGN16_RS03810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DGN16_RS03815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DGN16_RS03825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGN16_RS03825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGN16_RS03845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DGN16_RS03850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGN16_RS03855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DGN16_RS03875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DGN16_RS03880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DGN16_RS03885	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DGN16_RS03890	COG2205	protein histidine kinase activity
DGN16_RS03895	COG0745	RESPONSE REGULATOR receiver
DGN16_RS03900	COG0277	FAD linked oxidase domain protein
DGN16_RS03905	COG1988	membrane-bound metal-dependent
DGN16_RS03910	COG0792	nuclease activity
DGN16_RS03940	COG0275	rRNA processing
DGN16_RS03945	COG3116	cell division
DGN16_RS03955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DGN16_RS03960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DGN16_RS03965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGN16_RS03975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DGN16_RS03980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGN16_RS03985	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGN16_RS03990	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DGN16_RS04005	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DGN16_RS04015	COG0739	heme binding
DGN16_RS04020	COG0653	protein targeting
DGN16_RS04025	COG0494	nUDIX hydrolase
DGN16_RS04035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGN16_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS04045	COG0604	alcohol dehydrogenase
DGN16_RS04045	COG3321	synthase
DGN16_RS04065	COG0366	Alpha amylase catalytic
DGN16_RS04100	COG2226	methyltransferase
DGN16_RS04105	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DGN16_RS04115	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DGN16_RS04155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DGN16_RS04165	COG4106	trans-aconitate 2-methyltransferase activity
DGN16_RS04170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGN16_RS04180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN16_RS04185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DGN16_RS04200	COG0667	Aldo Keto reductase
DGN16_RS04210	COG4771	TonB-dependent receptor
DGN16_RS04230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN16_RS04235	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DGN16_RS04245	COG2175	clavaminate synthase activity
DGN16_RS04255	COG4181	ATPase activity
DGN16_RS04270	COG0642	Histidine kinase
DGN16_RS04280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DGN16_RS04300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DGN16_RS04305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DGN16_RS04320	COG3829	transcription factor binding
DGN16_RS04330	COG1116	anion transmembrane transporter activity
DGN16_RS04335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN16_RS04345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGN16_RS04350	COG0431	NADPH-dependent FMN reductase
DGN16_RS04375	COG0747	negative chemotaxis
DGN16_RS04385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DGN16_RS04395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DGN16_RS04400	COG2967	ApaG domain
DGN16_RS04405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DGN16_RS04410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DGN16_RS04415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN16_RS04420	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DGN16_RS04440	COG0123	including yeast histone deacetylase and acetoin utilization protein
DGN16_RS04445	COG2096	Adenosyltransferase
DGN16_RS04460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN16_RS04465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN16_RS04495	COG3384	dioxygenase
DGN16_RS04500	COG0583	DNA-binding transcription factor activity
DGN16_RS04515	COG1024	Enoyl-CoA hydratase
DGN16_RS04545	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DGN16_RS04570	COG0697	spore germination
DGN16_RS04580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN16_RS04605	COG2197	response regulator
DGN16_RS04615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DGN16_RS04625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DGN16_RS04630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN16_RS04635	COG0583	DNA-binding transcription factor activity
DGN16_RS04640	COG3634	alkyl hydroperoxide reductase activity
DGN16_RS04650	COG2890	protein-(glutamine-N5) methyltransferase activity
DGN16_RS04670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGN16_RS04670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGN16_RS04695	COG3039	Transposase
DGN16_RS04710	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DGN16_RS04750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGN16_RS04755	COG1404	Belongs to the peptidase S8 family
DGN16_RS04760	COG1404	Belongs to the peptidase S8 family
DGN16_RS04765	COG1404	Belongs to the peptidase S8 family
DGN16_RS04770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DGN16_RS04795	COG1295	ribonuclease BN
DGN16_RS04800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN16_RS04805	COG1254	Belongs to the acylphosphatase family
DGN16_RS04820	COG0521	Mo-molybdopterin cofactor biosynthetic process
DGN16_RS04830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DGN16_RS04835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DGN16_RS04845	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DGN16_RS04850	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DGN16_RS04860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DGN16_RS04865	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DGN16_RS04870	COG0193	aminoacyl-tRNA hydrolase activity
DGN16_RS04875	COG0012	GTP binding
DGN16_RS04895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGN16_RS04910	COG0250	Participates in transcription elongation, termination and antitermination
DGN16_RS04915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DGN16_RS04920	COG0081	regulation of translation
DGN16_RS04925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DGN16_RS04930	COG0222	ribosome binding
DGN16_RS04935	COG0085	RNA polymerase activity
DGN16_RS04940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DGN16_RS04945	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DGN16_RS04950	COG0049	tRNA binding
DGN16_RS04955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DGN16_RS04960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGN16_RS04965	COG0051	transcription antitermination factor activity, RNA binding
DGN16_RS04970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DGN16_RS04975	COG0088	Forms part of the polypeptide exit tunnel
DGN16_RS04980	COG0089	rRNA binding
DGN16_RS04985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DGN16_RS04990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DGN16_RS05000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DGN16_RS05005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DGN16_RS05010	COG0255	Belongs to the universal ribosomal protein uL29 family
DGN16_RS05015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DGN16_RS05025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DGN16_RS05030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DGN16_RS05040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DGN16_RS05045	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DGN16_RS05050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DGN16_RS05060	COG1841	ribosomal large subunit assembly
DGN16_RS05065	COG0200	Binds to the 23S rRNA
DGN16_RS05070	COG0201	protein transport
DGN16_RS05095	COG0203	ribosomal protein L17
DGN16_RS05100	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DGN16_RS05115	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DGN16_RS05130	COG0154	amidase activity
DGN16_RS05140	COG1217	gtp-binding protein TYPA
DGN16_RS05145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DGN16_RS05150	COG0039	L-malate dehydrogenase activity
DGN16_RS05155	COG0625	glutathione transferase activity
DGN16_RS05165	COG0446	pyridine nucleotide-disulphide oxidoreductase
DGN16_RS05165	COG1902	pentaerythritol trinitrate reductase activity
DGN16_RS05170	COG0604	alcohol dehydrogenase
DGN16_RS05195	COG0156	8-amino-7-oxononanoate synthase activity
DGN16_RS05205	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DGN16_RS05210	COG4208	sulfate ABC transporter
DGN16_RS05215	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DGN16_RS05245	COG0406	alpha-ribazole phosphatase activity
DGN16_RS05250	COG0285	dihydrofolate synthase activity
DGN16_RS05270	COG2833	Protein of unknown function (DUF455)
DGN16_RS05285	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN16_RS05290	COG0671	phosphoesterase, PA-phosphatase related
DGN16_RS05295	COG0438	transferase activity, transferring glycosyl groups
DGN16_RS05305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DGN16_RS05320	COG4783	chaperone-mediated protein folding
DGN16_RS05335	COG0473	3-isopropylmalate dehydrogenase activity
DGN16_RS05365	COG3852	Histidine kinase
DGN16_RS05375	COG0544	peptidyl-prolyl cis-trans isomerase activity
DGN16_RS05385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DGN16_RS05415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN16_RS05425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN16_RS05435	COG0328	RNA-DNA hybrid ribonuclease activity
DGN16_RS05440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGN16_RS05445	COG0631	protein serine/threonine phosphatase activity
DGN16_RS05460	COG0859	PFAM glycosyl transferase family 9
DGN16_RS05465	COG3642	lipopolysaccharide core region biosynthetic process
DGN16_RS05470	COG1234	tRNA 3'-trailer cleavage
DGN16_RS05475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DGN16_RS05485	COG0315	cyclic pyranopterin monophosphate synthase activity
DGN16_RS05490	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DGN16_RS05495	COG0314	molybdopterin synthase activity
DGN16_RS05525	COG3039	Transposase
DGN16_RS05545	COG3328	transposase activity
DGN16_RS05565	COG3039	Transposase
DGN16_RS05600	COG3328	transposase activity
DGN16_RS05620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DGN16_RS05625	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DGN16_RS05630	COG0537	adenosine 5'-monophosphoramidase activity
DGN16_RS05650	COG0714	Associated with various cellular activities
DGN16_RS05675	COG0424	maF-like protein
DGN16_RS05680	COG1399	metal-binding, possibly nucleic acid-binding protein
DGN16_RS05690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN16_RS05700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGN16_RS05705	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS05720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DGN16_RS05725	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DGN16_RS05750	COG3829	transcription factor binding
DGN16_RS05790	COG2373	Large extracellular alpha-helical protein
DGN16_RS05805	COG4953	penicillin-binding protein 1C
DGN16_RS05815	COG0678	peroxiredoxin activity
DGN16_RS05835	COG0330	HflC and HflK could
DGN16_RS05840	COG0330	HflC and HflK could
DGN16_RS05850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DGN16_RS05865	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS05870	COG1309	transcriptional regulator
DGN16_RS05915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DGN16_RS05920	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
DGN16_RS05925	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
DGN16_RS05930	COG3039	Transposase
DGN16_RS05935	COG0732	type I restriction modification DNA specificity domain
DGN16_RS05950	COG3039	Transposase
DGN16_RS05955	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DGN16_RS05985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGN16_RS05995	COG3039	Transposase
DGN16_RS06010	COG3387	PFAM Glycoside hydrolase 15-related
DGN16_RS06020	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS06025	COG3537	Alpha-1,2-mannosidase
DGN16_RS06030	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS06045	COG0492	ferredoxin-NADP+ reductase activity
DGN16_RS06080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGN16_RS06085	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGN16_RS06090	COG2080	2 iron, 2 sulfur cluster binding
DGN16_RS06125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGN16_RS06140	COG0587	DNA-directed DNA polymerase activity
DGN16_RS06160	COG1297	OPT oligopeptide transporter protein
DGN16_RS06175	COG0823	Involved in the tonB-independent uptake of proteins
DGN16_RS06175	COG1506	peptidase
DGN16_RS06190	COG1917	Cupin 2, conserved barrel domain protein
DGN16_RS06190	COG2207	Transcriptional regulator
DGN16_RS06210	COG0753	catalase activity
DGN16_RS06215	COG0656	L-ascorbic acid biosynthetic process
DGN16_RS06225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGN16_RS06225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGN16_RS06230	COG2814	Major facilitator Superfamily
DGN16_RS06245	COG2194	sulfuric ester hydrolase activity
DGN16_RS06260	COG0745	RESPONSE REGULATOR receiver
DGN16_RS06265	COG0642	Histidine kinase
DGN16_RS06275	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DGN16_RS06280	COG2894	cell division
DGN16_RS06285	COG0850	regulation of cytokinetic process
DGN16_RS06295	COG4585	Histidine kinase
DGN16_RS06300	COG2197	response regulator
DGN16_RS06315	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DGN16_RS06340	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DGN16_RS06350	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DGN16_RS06370	COG1946	Acyl-CoA thioesterase
DGN16_RS06385	COG0824	Thioesterase
DGN16_RS06390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DGN16_RS06395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DGN16_RS06400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DGN16_RS06405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DGN16_RS06410	COG0268	Binds directly to 16S ribosomal RNA
DGN16_RS06420	COG0196	riboflavin kinase activity
DGN16_RS06425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DGN16_RS06430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DGN16_RS06435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DGN16_RS06470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DGN16_RS06475	COG1845	cytochrome c oxidase, subunit III
DGN16_RS06480	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DGN16_RS06495	COG3328	transposase activity
DGN16_RS06500	COG3152	Membrane
DGN16_RS06510	COG2207	Transcriptional regulator
DGN16_RS06515	COG0326	Molecular chaperone. Has ATPase activity
DGN16_RS06525	COG1366	Belongs to the anti-sigma-factor antagonist family
DGN16_RS06530	COG1366	Belongs to the anti-sigma-factor antagonist family
DGN16_RS06535	COG2172	sigma factor antagonist activity
DGN16_RS06560	COG4771	TonB-dependent receptor
DGN16_RS06570	COG5507	3-demethylubiquinone-9 3-methyltransferase
DGN16_RS06575	COG2205	protein histidine kinase activity
DGN16_RS06585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGN16_RS06590	COG2205	protein histidine kinase activity
DGN16_RS06590	COG3437	response regulator, receiver
DGN16_RS06590	COG3850	Histidine kinase
DGN16_RS06590	COG4999	Histidine kinase
DGN16_RS06595	COG4191	Histidine kinase
DGN16_RS06595	COG0784	Response regulator, receiver
DGN16_RS06625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGN16_RS06630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DGN16_RS06645	COG0228	four-way junction DNA binding
DGN16_RS06650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DGN16_RS06655	COG0336	Belongs to the RNA methyltransferase TrmD family
DGN16_RS06660	COG0335	large ribosomal subunit rRNA binding
DGN16_RS06665	COG0534	Mate efflux family protein
DGN16_RS06685	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DGN16_RS06695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DGN16_RS06700	COG3328	transposase activity
DGN16_RS06725	COG3250	beta-galactosidase activity
DGN16_RS06730	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DGN16_RS06750	COG1960	acyl-CoA dehydrogenase activity
DGN16_RS06755	COG1024	Enoyl-CoA hydratase
DGN16_RS06780	COG3039	Transposase
DGN16_RS06785	COG3039	Transposase
DGN16_RS06790	COG3039	Transposase
DGN16_RS06815	COG3039	Transposase
DGN16_RS06820	COG2801	Transposase and inactivated derivatives
DGN16_RS06830	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGN16_RS06830	COG1024	Enoyl-CoA hydratase
DGN16_RS06845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGN16_RS06850	COG0481	GTPase activity
DGN16_RS06865	COG0571	ribonuclease III activity
DGN16_RS06870	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DGN16_RS06875	COG1381	Involved in DNA repair and RecF pathway recombination
DGN16_RS06885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DGN16_RS06890	COG2954	triphosphatase activity
DGN16_RS06895	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DGN16_RS06900	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DGN16_RS06905	COG3046	protein related to deoxyribodipyrimidine photolyase
DGN16_RS06910	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN16_RS06915	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DGN16_RS06920	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DGN16_RS06925	COG1278	Cold shock
DGN16_RS06930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN16_RS06940	COG1201	RNA secondary structure unwinding
DGN16_RS06945	COG1793	dna ligase
DGN16_RS06955	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DGN16_RS06955	COG1793	dna ligase
DGN16_RS06985	COG0183	Belongs to the thiolase family
DGN16_RS07010	COG1451	nucleotide metabolic process
DGN16_RS07015	COG5487	UPF0391 membrane protein
DGN16_RS07025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DGN16_RS07040	COG1077	Cell shape determining protein MreB Mrl
DGN16_RS07045	COG1047	Peptidyl-prolyl cis-trans
DGN16_RS07055	COG2824	Alkylphosphonate utilization operon protein PhnA
DGN16_RS07060	COG1902	pentaerythritol trinitrate reductase activity
DGN16_RS07065	COG2814	Major facilitator Superfamily
DGN16_RS07100	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DGN16_RS07100	COG0392	lysyltransferase activity
DGN16_RS07110	COG0251	oxidation-reduction process
DGN16_RS07115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGN16_RS07130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGN16_RS07155	COG1595	DNA-templated transcription, initiation
DGN16_RS07170	COG2878	Part of a membrane complex involved in electron transport
DGN16_RS07180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN16_RS07180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN16_RS07195	COG3039	Transposase
DGN16_RS07200	COG1131	(ABC) transporter
DGN16_RS07205	COG0346	lactoylglutathione lyase activity
DGN16_RS07210	COG0833	amino acid
DGN16_RS07215	COG2040	homocysteine
DGN16_RS07225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGN16_RS07255	COG1695	Transcriptional regulator
DGN16_RS07275	COG1981	membrane
DGN16_RS07290	COG0825	malonyl-CoA metabolic process
DGN16_RS07305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN16_RS07310	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN16_RS07315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGN16_RS07320	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN16_RS07335	COG0750	zinc metalloprotease
DGN16_RS07340	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DGN16_RS07345	COG0575	Belongs to the CDS family
DGN16_RS07350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DGN16_RS07355	COG0233	cytoplasmic translational termination
DGN16_RS07360	COG0528	UMP kinase activity
DGN16_RS07370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DGN16_RS07375	COG0052	Belongs to the universal ribosomal protein uS2 family
DGN16_RS07415	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DGN16_RS07425	COG1393	Belongs to the ArsC family
DGN16_RS07430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGN16_RS07435	COG0367	asparagine synthase
DGN16_RS07445	COG4774	siderophore transport
DGN16_RS07460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DGN16_RS07485	COG1566	PFAM secretion protein HlyD family protein
DGN16_RS07490	COG2814	Major facilitator Superfamily
DGN16_RS07540	COG0339	signal peptide processing
DGN16_RS07545	COG0386	Belongs to the glutathione peroxidase family
DGN16_RS07600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DGN16_RS07605	COG0084	hydrolase, TatD family'
DGN16_RS07620	COG1960	acyl-CoA dehydrogenase activity
DGN16_RS07635	COG0367	asparagine synthase
DGN16_RS07645	COG0305	Participates in initiation and elongation during chromosome replication
DGN16_RS07650	COG0415	Belongs to the DNA photolyase family
DGN16_RS07660	COG0583	DNA-binding transcription factor activity
DGN16_RS07705	COG3706	GGDEF domain
DGN16_RS07740	COG3328	transposase activity
DGN16_RS07745	COG0582	viral genome integration into host DNA
DGN16_RS07760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DGN16_RS07775	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN16_RS07785	COG0497	DNA recombination
DGN16_RS07790	COG1420	regulation of RNA biosynthetic process
DGN16_RS07795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DGN16_RS07800	COG0443	Heat shock 70 kDa protein
DGN16_RS07805	COG0484	heat shock protein binding
DGN16_RS07810	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DGN16_RS07840	COG0583	DNA-binding transcription factor activity
DGN16_RS07845	COG1132	(ABC) transporter
DGN16_RS07870	COG0567	Dehydrogenase, E1 component
DGN16_RS07880	COG2850	peptidyl-arginine hydroxylation
DGN16_RS07900	COG1253	flavin adenine dinucleotide binding
DGN16_RS07930	COG1131	(ABC) transporter
DGN16_RS07935	COG1725	Transcriptional regulator
DGN16_RS07945	COG0386	Belongs to the glutathione peroxidase family
DGN16_RS07960	COG2900	Belongs to the SlyX family
DGN16_RS07985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN16_RS07995	COG0646	methionine synthase
DGN16_RS07995	COG1410	methionine synthase
DGN16_RS08000	COG1410	methionine synthase
DGN16_RS08000	COG0646	methionine synthase
DGN16_RS08005	COG2226	methyltransferase
DGN16_RS08020	COG1960	acyl-CoA dehydrogenase activity
DGN16_RS08035	COG0557	exoribonuclease II activity
DGN16_RS08045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGN16_RS08055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGN16_RS08065	COG0704	Plays a role in the regulation of phosphate uptake
DGN16_RS08070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DGN16_RS08075	COG0581	inorganic phosphate transmembrane transporter activity
DGN16_RS08080	COG0573	inorganic phosphate transmembrane transporter activity
DGN16_RS08085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DGN16_RS08110	COG0659	secondary active sulfate transmembrane transporter activity
DGN16_RS08115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DGN16_RS08125	COG1024	Enoyl-CoA hydratase
DGN16_RS08135	COG0494	nUDIX hydrolase
DGN16_RS08170	COG0488	(ABC) transporter
DGN16_RS08180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGN16_RS08180	COG0116	Belongs to the methyltransferase superfamily
DGN16_RS08185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DGN16_RS08210	COG2925	Exonuclease
DGN16_RS08215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN16_RS08220	COG3844	kynureninase activity
DGN16_RS08230	COG0662	Cupin 2, conserved barrel domain protein
DGN16_RS08235	COG0288	reversible hydration of carbon dioxide
DGN16_RS08285	COG3039	Transposase
DGN16_RS08320	COG0017	Asparaginyl-tRNA synthetase
DGN16_RS08325	COG0316	Belongs to the HesB IscA family
DGN16_RS08330	COG0360	Binds together with S18 to 16S ribosomal RNA
DGN16_RS08335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DGN16_RS08340	COG0359	binds to the 23S rRNA
DGN16_RS08355	COG3115	cell septum assembly
DGN16_RS08365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN16_RS08370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DGN16_RS08375	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DGN16_RS08385	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DGN16_RS08395	COG4993	Dehydrogenase
DGN16_RS08405	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DGN16_RS08415	COG2986	histidine ammonia-lyase
DGN16_RS08420	COG1228	amidohydrolase
DGN16_RS08455	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DGN16_RS08460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DGN16_RS08465	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DGN16_RS08470	COG0077	Prephenate dehydratase
DGN16_RS08470	COG1605	Chorismate mutase
DGN16_RS08475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DGN16_RS08490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DGN16_RS08495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DGN16_RS08500	COG0583	DNA-binding transcription factor activity
DGN16_RS08520	COG3328	transposase activity
DGN16_RS08540	COG0840	transmembrane signaling receptor activity
DGN16_RS08565	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DGN16_RS08570	COG0784	Response regulator, receiver
DGN16_RS08570	COG4191	Histidine kinase
DGN16_RS08585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN16_RS08595	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGN16_RS08605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGN16_RS08620	COG1595	DNA-templated transcription, initiation
DGN16_RS08670	COG2244	polysaccharide biosynthetic process
DGN16_RS08700	COG2264	protein methyltransferase activity
DGN16_RS08710	COG0438	transferase activity, transferring glycosyl groups
DGN16_RS08725	COG1136	(ABC) transporter
DGN16_RS08760	COG1253	flavin adenine dinucleotide binding
DGN16_RS08770	COG0306	phosphate transporter
DGN16_RS08795	COG0504	CTP synthase activity
DGN16_RS08810	COG0148	phosphopyruvate hydratase activity
DGN16_RS08815	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DGN16_RS08820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DGN16_RS08825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DGN16_RS08830	COG0585	pseudouridine synthase activity
DGN16_RS08835	COG2840	Smr protein MutS2
DGN16_RS08840	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DGN16_RS08845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGN16_RS08850	COG1238	metal cluster binding
DGN16_RS08865	COG1534	Rna-binding protein
DGN16_RS08870	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DGN16_RS08880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DGN16_RS08885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DGN16_RS08895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DGN16_RS08900	COG1546	Belongs to the CinA family
DGN16_RS08910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGN16_RS08915	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DGN16_RS08920	COG2137	regulation of response to DNA damage stimulus
DGN16_RS08925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DGN16_RS08930	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DGN16_RS08945	COG1741	Belongs to the pirin family
DGN16_RS08950	COG0583	DNA-binding transcription factor activity
DGN16_RS08975	COG0351	phosphomethylpyrimidine kinase
DGN16_RS08990	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DGN16_RS08995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DGN16_RS09010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGN16_RS09020	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DGN16_RS09025	COG3734	2-keto-3-deoxy-galactonokinase
DGN16_RS09035	COG4948	Mandelate Racemase Muconate Lactonizing
DGN16_RS09040	COG0800	Aldolase
DGN16_RS09075	COG1501	Belongs to the glycosyl hydrolase 31 family
DGN16_RS09085	COG1070	Carbohydrate kinase
DGN16_RS09095	COG3328	transposase activity
DGN16_RS09110	COG3328	transposase activity
DGN16_RS09145	COG3039	Transposase
DGN16_RS09155	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGN16_RS09160	COG1469	GTP cyclohydrolase I activity
DGN16_RS09180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DGN16_RS09185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DGN16_RS09190	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DGN16_RS09225	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN16_RS09235	COG2203	Gaf domain
DGN16_RS09235	COG5001	Diguanylate cyclase
DGN16_RS09235	COG4251	negative regulation of phosphorylation
DGN16_RS09235	COG3706	GGDEF domain
DGN16_RS09240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN16_RS09245	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DGN16_RS09255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DGN16_RS09275	COG1794	racemase activity, acting on amino acids and derivatives
DGN16_RS09280	COG0697	spore germination
DGN16_RS09285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DGN16_RS09290	COG0167	dihydroorotate dehydrogenase activity
DGN16_RS09305	COG1012	belongs to the aldehyde dehydrogenase family
DGN16_RS09320	COG1215	transferase activity, transferring glycosyl groups
DGN16_RS09325	COG0726	polysaccharide deacetylase
DGN16_RS09325	COG1649	PFAM Uncharacterised BCR, COG1649
DGN16_RS09405	COG3328	transposase activity
DGN16_RS09445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN16_RS09450	COG0124	histidyl-tRNA synthetase
DGN16_RS09460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DGN16_RS09465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DGN16_RS09470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN16_RS09475	COG0131	Imidazoleglycerol-phosphate dehydratase
DGN16_RS09475	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DGN16_RS09480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DGN16_RS09485	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DGN16_RS09490	COG0107	imidazoleglycerol-phosphate synthase activity
DGN16_RS09495	COG0140	phosphoribosyl-ATP diphosphatase activity
DGN16_RS09495	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DGN16_RS09510	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DGN16_RS09515	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DGN16_RS09520	COG0235	Class ii aldolase
DGN16_RS09525	COG0531	amino acid
DGN16_RS09530	COG0531	amino acid
DGN16_RS09540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DGN16_RS09545	COG0277	FAD linked oxidase domain protein
DGN16_RS09565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGN16_RS09610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGN16_RS09615	COG2258	MOSC domain
DGN16_RS09620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DGN16_RS09625	COG0505	Belongs to the CarA family
DGN16_RS09635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DGN16_RS09640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN16_RS09650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DGN16_RS09660	COG3279	Response regulator of the LytR AlgR family
DGN16_RS09680	COG2205	protein histidine kinase activity
DGN16_RS09680	COG2198	Histidine kinase
DGN16_RS09680	COG0784	Response regulator, receiver
DGN16_RS09685	COG2205	protein histidine kinase activity
DGN16_RS09685	COG2198	Histidine kinase
DGN16_RS09685	COG0784	Response regulator, receiver
DGN16_RS09690	COG1024	Enoyl-CoA hydratase
DGN16_RS09695	COG0318	PFAM AMP-dependent synthetase and ligase
DGN16_RS09725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN16_RS09735	COG2201	protein-glutamate methylesterase activity
DGN16_RS09740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DGN16_RS09750	COG0840	transmembrane signaling receptor activity
DGN16_RS09765	COG0835	chemotaxis
DGN16_RS09785	COG0840	transmembrane signaling receptor activity
DGN16_RS09790	COG0840	transmembrane signaling receptor activity
DGN16_RS09795	COG0840	transmembrane signaling receptor activity
DGN16_RS09800	COG0840	transmembrane signaling receptor activity
DGN16_RS09810	COG0840	transmembrane signaling receptor activity
DGN16_RS09815	COG0840	transmembrane signaling receptor activity
DGN16_RS09820	COG0840	transmembrane signaling receptor activity
DGN16_RS09825	COG0840	transmembrane signaling receptor activity
DGN16_RS09840	COG0840	transmembrane signaling receptor activity
DGN16_RS09850	COG0745	RESPONSE REGULATOR receiver
DGN16_RS09860	COG0835	chemotaxis
DGN16_RS09870	COG1360	Flagellar Motor Protein
DGN16_RS09875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DGN16_RS09885	COG3039	Transposase
DGN16_RS09905	COG3039	Transposase
DGN16_RS09935	COG0643	Histidine kinase
DGN16_RS09935	COG0784	Response regulator, receiver
DGN16_RS09935	COG2198	Histidine kinase
DGN16_RS09965	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DGN16_RS09990	COG1684	flagellar biosynthetic protein fliR
DGN16_RS10010	COG3190	flagellar
DGN16_RS10060	COG1677	Flagellar hook-basal body complex protein FliE
DGN16_RS10075	COG3039	Transposase
DGN16_RS10105	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS10110	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS10115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN16_RS10135	COG2201	protein-glutamate methylesterase activity
DGN16_RS10165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DGN16_RS10180	COG3039	Transposase
DGN16_RS10185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DGN16_RS10195	COG1705	Flagellar rod assembly protein muramidase FlgJ
DGN16_RS10195	COG3951	Flagellar rod assembly protein muramidase FlgJ
DGN16_RS10200	COG1706	bacterial-type flagellum-dependent cell motility
DGN16_RS10205	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DGN16_RS10215	COG4787	bacterial-type flagellum-dependent cell motility
DGN16_RS10225	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DGN16_RS10230	COG1558	bacterial-type flagellum-dependent cell motility
DGN16_RS10240	COG0784	Response regulator, receiver
DGN16_RS10240	COG0835	chemotaxis
DGN16_RS10265	COG5002	protein histidine kinase activity
DGN16_RS10295	COG2915	High frequency lysogenization protein hflD homolog
DGN16_RS10300	COG0482	sulfurtransferase activity
DGN16_RS10315	COG0542	response to heat
DGN16_RS10325	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DGN16_RS10335	COG0492	ferredoxin-NADP+ reductase activity
DGN16_RS10340	COG1674	ftsk spoiiie
DGN16_RS10350	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DGN16_RS10360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DGN16_RS10365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DGN16_RS10370	COG0183	Belongs to the thiolase family
DGN16_RS10375	COG1024	Enoyl-CoA hydratase
DGN16_RS10375	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGN16_RS10390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DGN16_RS10400	COG1426	Protein conserved in bacteria
DGN16_RS10410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN16_RS10415	COG1160	GTP binding
DGN16_RS10420	COG0303	'Molybdopterin
DGN16_RS10425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DGN16_RS10460	COG0708	Exodeoxyribonuclease III
DGN16_RS10470	COG0303	'Molybdopterin
DGN16_RS10475	COG0746	molybdenum cofactor guanylyltransferase activity
DGN16_RS10505	COG1914	H( )-stimulated, divalent metal cation uptake system
DGN16_RS10520	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DGN16_RS10525	COG0668	transmembrane transport
DGN16_RS10535	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DGN16_RS10550	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS10555	COG1183	phosphatidylcholine synthase activity
DGN16_RS10565	COG3243	poly(R)-hydroxyalkanoic acid synthase
DGN16_RS10580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN16_RS10580	COG0723	plastoquinol--plastocyanin reductase activity
DGN16_RS10590	COG2183	response to ionizing radiation
DGN16_RS10595	COG0784	Response regulator, receiver
DGN16_RS10595	COG2205	protein histidine kinase activity
DGN16_RS10660	COG0800	Aldolase
DGN16_RS10665	COG0129	dihydroxy-acid dehydratase activity
DGN16_RS10670	COG0363	glucosamine-6-phosphate deaminase activity
DGN16_RS10675	COG0837	glucose binding
DGN16_RS10680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGN16_RS10690	COG0354	folic acid binding
DGN16_RS10705	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DGN16_RS10720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DGN16_RS10725	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DGN16_RS10735	COG4591	ABC-type transport system involved in lipoprotein release permease component
DGN16_RS10740	COG1136	(ABC) transporter
DGN16_RS10755	COG0811	peptide transport
DGN16_RS10760	COG0848	biopolymer transport protein
DGN16_RS10765	COG1132	(ABC) transporter
DGN16_RS10770	COG1663	tetraacyldisaccharide 4'-kinase activity
DGN16_RS10775	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DGN16_RS10780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DGN16_RS10790	COG0322	excinuclease ABC activity
DGN16_RS10795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGN16_RS10825	COG3328	transposase activity
DGN16_RS10850	COG3328	transposase activity
DGN16_RS10860	COG0366	Alpha amylase catalytic
DGN16_RS10870	COG3039	Transposase
DGN16_RS10895	COG3039	Transposase
DGN16_RS10930	COG2211	Major facilitator Superfamily
DGN16_RS10930	COG2190	(PTS) system
DGN16_RS10945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DGN16_RS10950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DGN16_RS10965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DGN16_RS10970	COG0072	phenylalanine-tRNA ligase activity
DGN16_RS10970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN16_RS11020	COG0438	transferase activity, transferring glycosyl groups
DGN16_RS11025	COG0438	transferase activity, transferring glycosyl groups
DGN16_RS11035	COG0438	transferase activity, transferring glycosyl groups
DGN16_RS11060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN16_RS11065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN16_RS11070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN16_RS11090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DGN16_RS11100	COG1960	acyl-CoA dehydrogenase activity
DGN16_RS11110	COG3040	lipid binding
DGN16_RS11120	COG0582	viral genome integration into host DNA
DGN16_RS11130	COG3039	Transposase
DGN16_RS11145	COG3039	Transposase
DGN16_RS11170	COG3039	Transposase
DGN16_RS11200	COG0784	Response regulator, receiver
DGN16_RS11200	COG4191	Histidine kinase
DGN16_RS11205	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DGN16_RS11210	COG1194	a g-specific adenine glycosylase
DGN16_RS11215	COG0552	protein localization to endoplasmic reticulum
DGN16_RS11225	COG3938	Belongs to the proline racemase family
DGN16_RS11230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN16_RS11245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGN16_RS11255	COG0006	proline dipeptidase activity
DGN16_RS11270	COG0531	amino acid
DGN16_RS11345	COG3039	Transposase
DGN16_RS11360	COG0326	Molecular chaperone. Has ATPase activity
DGN16_RS11365	COG0742	ribosomal rna small subunit methyltransferase
DGN16_RS11370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DGN16_RS11380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DGN16_RS11385	COG0405	Gamma-glutamyltransferase
DGN16_RS11390	COG3291	Pkd domain containing protein
DGN16_RS11395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DGN16_RS11435	COG0343	queuine tRNA-ribosyltransferase activity
DGN16_RS11440	COG1862	Preprotein translocase
DGN16_RS11450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DGN16_RS11520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGN16_RS11520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGN16_RS11525	COG1105	Belongs to the carbohydrate kinase PfkB family
DGN16_RS11530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGN16_RS11530	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN16_RS11535	COG1609	Transcriptional regulator
DGN16_RS11540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN16_RS11545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_RS11555	COG2902	Dehydrogenase
DGN16_RS11565	COG0604	alcohol dehydrogenase
DGN16_RS11565	COG3321	synthase
DGN16_RS11575	COG1902	pentaerythritol trinitrate reductase activity
DGN16_RS11585	COG0300	oxidoreductase activity
DGN16_RS11605	COG0477	Major facilitator Superfamily
DGN16_RS11620	COG0784	Response regulator, receiver
DGN16_RS11620	COG2205	protein histidine kinase activity
DGN16_RS11620	COG5002	protein histidine kinase activity
DGN16_RS11625	COG2733	membrane
DGN16_RS11635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DGN16_RS11640	COG2223	nitrite transmembrane transporter activity
DGN16_RS11645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DGN16_RS11650	COG0243	molybdopterin cofactor binding
DGN16_RS11660	COG0477	Major facilitator Superfamily
DGN16_RS11665	COG2703	oxygen carrier activity
DGN16_RS11675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN16_RS11680	COG0174	glutamine synthetase
DGN16_RS11685	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DGN16_RS11705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DGN16_RS11735	COG1176	ABC-type spermidine putrescine transport system, permease component I
DGN16_RS11740	COG1177	transmembrane transport
DGN16_RS11745	COG1012	belongs to the aldehyde dehydrogenase family
DGN16_RS11760	COG4535	Mg2 and Co2 transporter CorC
DGN16_RS11770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DGN16_RS11780	COG1702	phosphate starvation-inducible protein PhoH
DGN16_RS11785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGN16_RS11800	COG0741	lytic transglycosylase activity
DGN16_RS11805	COG0723	plastoquinol--plastocyanin reductase activity
DGN16_RS11810	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DGN16_RS11815	COG2857	Cytochrome c1
DGN16_RS11820	COG0625	glutathione transferase activity
DGN16_RS11825	COG2969	positive regulation of protein catabolic process
DGN16_RS11845	COG1201	RNA secondary structure unwinding
DGN16_RS11850	COG2094	Belongs to the DNA glycosylase MPG family
DGN16_RS11855	COG0840	transmembrane signaling receptor activity
DGN16_RS11860	COG0835	chemotaxis
DGN16_RS11905	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGN16_RS11915	COG1570	exodeoxyribonuclease VII activity
DGN16_RS11920	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGN16_RS11925	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DGN16_RS11925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGN16_RS11930	COG0802	atpase or kinase
DGN16_RS11935	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGN16_RS11940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DGN16_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS11970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN16_RS11975	COG0501	Belongs to the peptidase M48B family
DGN16_RS11980	COG3039	Transposase
DGN16_RS11990	COG2081	HI0933 family
DGN16_RS11995	COG4681	YaeQ
DGN16_RS12005	COG0625	glutathione transferase activity
DGN16_RS12015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DGN16_RS12020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DGN16_RS12025	COG0513	Belongs to the DEAD box helicase family
DGN16_RS12030	COG0488	(ABC) transporter
DGN16_RS12045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DGN16_RS12050	COG0483	inositol monophosphate 1-phosphatase activity
DGN16_RS12065	COG3300	MHYT domain
DGN16_RS12065	COG5001	Diguanylate cyclase
DGN16_RS12070	COG1509	lysine 2,3-aminomutase activity
DGN16_RS12075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGN16_RS12085	COG0402	S-adenosylhomocysteine deaminase activity
DGN16_RS12090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DGN16_RS12115	COG2801	Transposase and inactivated derivatives
DGN16_RS12155	COG4302	ethanolamine ammonia-lyase activity
DGN16_RS12180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DGN16_RS12185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DGN16_RS12200	COG2166	iron-sulfur cluster assembly
DGN16_RS12205	COG0215	cysteine-tRNA ligase activity
DGN16_RS12215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DGN16_RS12220	COG0137	argininosuccinate synthase activity
DGN16_RS12230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGN16_RS12235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DGN16_RS12245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DGN16_RS12250	COG0165	Argininosuccinate lyase
DGN16_RS12260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DGN16_RS12265	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DGN16_RS12300	COG1388	LysM domain
DGN16_RS12300	COG4942	peptidase
DGN16_RS12335	COG3328	transposase activity
DGN16_RS12350	COG1294	oxidase, subunit
DGN16_RS12365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DGN16_RS12370	COG1278	Cold shock
DGN16_RS12375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN16_RS12395	COG1138	Cytochrome C-type biogenesis protein
DGN16_RS12400	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGN16_RS12420	COG4133	protoheme IX ABC transporter activity
DGN16_RS12425	COG0436	Aminotransferase
DGN16_RS12445	COG1187	pseudouridine synthase activity
DGN16_RS12450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DGN16_RS12455	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DGN16_RS12460	COG2350	Protein conserved in bacteria
DGN16_RS12490	COG1175	transmembrane transport
DGN16_RS12495	COG0395	ABC-type sugar transport system, permease component
DGN16_RS12520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGN16_RS12525	COG2957	Belongs to the agmatine deiminase family
DGN16_RS12540	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DGN16_RS12545	COG0539	negative regulation of cytoplasmic translation
DGN16_RS12550	COG0776	regulation of translation
DGN16_RS12560	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DGN16_RS12565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGN16_RS12575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DGN16_RS12580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGN16_RS12580	COG0475	glutathione-regulated potassium exporter activity
DGN16_RS12590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DGN16_RS12600	COG0519	Catalyzes the synthesis of GMP from XMP
DGN16_RS12600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGN16_RS12610	COG3328	transposase activity
DGN16_RS12620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGN16_RS12640	COG2197	response regulator
DGN16_RS12655	COG1335	isochorismatase
DGN16_RS12685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGN16_RS12685	COG1648	precorrin-2 dehydrogenase activity
DGN16_RS12700	COG3685	Protein conserved in bacteria
DGN16_RS12720	COG5001	Diguanylate cyclase
DGN16_RS12730	COG4566	intracellular signal transduction
DGN16_RS12765	COG3275	phosphorelay sensor kinase activity
DGN16_RS12770	COG3279	Response regulator of the LytR AlgR family
DGN16_RS12810	COG4191	Histidine kinase
DGN16_RS12825	COG3920	Histidine kinase
DGN16_RS12850	COG3220	belongs to the UPF0276 family
DGN16_RS12890	COG0583	DNA-binding transcription factor activity
DGN16_RS12900	COG3039	Transposase
DGN16_RS12940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN16_RS13025	COG4221	oxidoreductase activity
DGN16_RS13025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN16_RS13025	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS13025	COG3321	synthase
DGN16_RS13030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGN16_RS13035	COG1136	(ABC) transporter
DGN16_RS13125	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS13130	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGN16_RS13135	COG1073	alpha beta
DGN16_RS13135	COG2226	methyltransferase
DGN16_RS13180	COG0316	Belongs to the HesB IscA family
DGN16_RS13180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DGN16_RS13185	COG2154	pterin-4-alpha-carbinolamine dehydratase
DGN16_RS13195	COG0428	transporter
DGN16_RS13200	COG3064	Membrane
DGN16_RS13210	COG1530	ribonuclease E activity
DGN16_RS13220	COG1054	Belongs to the UPF0176 family
DGN16_RS13240	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DGN16_RS13325	COG3702	type iv secretory pathway
DGN16_RS13345	COG2948	multi-organism process
DGN16_RS13365	COG3505	Type IV secretory pathway VirD4
DGN16_RS13380	COG0556	nucleotide-excision repair
DGN16_RS13390	COG3328	transposase activity
DGN16_RS13455	COG1611	Belongs to the LOG family
DGN16_RS13465	COG2095	MarC family integral membrane protein
DGN16_RS13475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGN16_RS13510	COG1185	polyribonucleotide nucleotidyltransferase activity
DGN16_RS13515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DGN16_RS13520	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DGN16_RS13525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DGN16_RS13530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DGN16_RS13535	COG0195	Participates in both transcription termination and antitermination
DGN16_RS13540	COG0779	Required for maturation of 30S ribosomal subunits
DGN16_RS13550	COG1007	ATP synthesis coupled electron transport
DGN16_RS13575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN16_RS13580	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DGN16_RS13590	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DGN16_RS13595	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DGN16_RS13600	COG0649	NAD binding
DGN16_RS13605	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN16_RS13610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN16_RS13615	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN16_RS13630	COG0149	triose-phosphate isomerase activity
DGN16_RS13635	COG0300	oxidoreductase activity
DGN16_RS13665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGN16_RS13670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DGN16_RS13675	COG0159	tryptophan synthase activity
DGN16_RS13685	COG0133	tryptophan synthase activity
DGN16_RS13695	COG0135	phosphoribosylanthranilate isomerase activity
DGN16_RS13700	COG0101	tRNA pseudouridine synthase activity
DGN16_RS13715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DGN16_RS13720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DGN16_RS13725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DGN16_RS13730	COG2890	protein-(glutamine-N5) methyltransferase activity
DGN16_RS13740	COG0688	phosphatidylethanolamine metabolic process
DGN16_RS13750	COG0433	COG0433 Predicted ATPase
DGN16_RS13755	COG0494	nUDIX hydrolase
DGN16_RS13770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN16_RS13775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGN16_RS13780	COG3328	transposase activity
DGN16_RS13835	COG0717	Belongs to the dCTP deaminase family
DGN16_RS13840	COG0489	protein tyrosine kinase activity
DGN16_RS13880	COG3590	peptidase
DGN16_RS13885	COG3590	peptidase
DGN16_RS13905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGN16_RS13910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN16_RS13915	COG2311	Membrane
DGN16_RS13920	COG1047	Peptidyl-prolyl cis-trans
DGN16_RS13925	COG0791	NLP P60 protein
DGN16_RS13930	COG0791	NLP P60 protein
DGN16_RS13940	COG4106	trans-aconitate 2-methyltransferase activity
DGN16_RS13945	COG1301	dicarboxylic acid transport
DGN16_RS13950	COG1785	Belongs to the alkaline phosphatase family
DGN16_RS13955	COG0037	tRNA processing
DGN16_RS13960	COG1722	exodeoxyribonuclease VII activity
DGN16_RS13965	COG0142	geranyltranstransferase activity
DGN16_RS13970	COG4104	PAAR repeat-containing protein
DGN16_RS13980	COG0312	modulator of DNA gyrase
DGN16_RS13985	COG3028	Belongs to the UPF0307 family
DGN16_RS13990	COG0312	modulator of DNA gyrase
DGN16_RS14000	COG3164	Protein of unknown function
DGN16_RS14010	COG0424	maF-like protein
DGN16_RS14015	COG2968	Membrane
DGN16_RS14030	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DGN16_RS14045	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DGN16_RS14060	COG0495	leucyl-tRNA aminoacylation
DGN16_RS14070	COG3118	belongs to the thioredoxin family
DGN16_RS14115	COG2155	Conserved Protein
DGN16_RS14160	COG1132	(ABC) transporter
DGN16_RS14185	COG1538	Outer membrane efflux protein
DGN16_RS14190	COG0745	RESPONSE REGULATOR receiver
DGN16_RS14195	COG5000	phosphorelay sensor kinase activity
DGN16_RS14195	COG5002	protein histidine kinase activity
DGN16_RS14200	COG0475	glutathione-regulated potassium exporter activity
DGN16_RS14210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGN16_RS14230	COG1187	pseudouridine synthase activity
DGN16_RS14235	COG5002	protein histidine kinase activity
DGN16_RS14235	COG5001	Diguanylate cyclase
DGN16_RS14245	COG1595	DNA-templated transcription, initiation
DGN16_RS14355	COG0667	Aldo Keto reductase
DGN16_RS14360	COG2814	Major facilitator Superfamily
DGN16_RS14365	COG0583	DNA-binding transcription factor activity
DGN16_RS14375	COG2207	Transcriptional regulator
DGN16_RS14385	COG1309	transcriptional regulator
DGN16_RS14395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN16_RS14410	COG0735	belongs to the Fur family
DGN16_RS14415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN16_RS14440	COG4452	Inner membrane protein CreD
DGN16_RS14450	COG2205	protein histidine kinase activity
DGN16_RS14455	COG0745	RESPONSE REGULATOR receiver
DGN16_RS14460	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DGN16_RS14470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DGN16_RS14480	COG2198	Histidine kinase
DGN16_RS14480	COG0643	Histidine kinase
DGN16_RS14485	COG0840	transmembrane signaling receptor activity
DGN16_RS14490	COG0835	chemotaxis
DGN16_RS14495	COG2200	EAL domain
DGN16_RS14495	COG2202	Pas domain
DGN16_RS14495	COG2199	diguanylate cyclase activity
DGN16_RS14500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGN16_RS14505	COG2201	protein-glutamate methylesterase activity
DGN16_RS14510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN16_RS14515	COG3590	peptidase
DGN16_RS14525	COG0588	phosphoglycerate mutase activity
DGN16_RS14530	COG1515	deoxyribonuclease V activity
DGN16_RS14545	COG1741	Belongs to the pirin family
DGN16_RS14560	COG1741	Belongs to the pirin family
DGN16_RS14565	COG1966	Carbon starvation protein
DGN16_RS14570	COG2879	small protein
DGN16_RS14605	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DGN16_RS14610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGN16_RS14615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGN16_RS14620	COG2080	2 iron, 2 sulfur cluster binding
DGN16_RS14625	COG0604	alcohol dehydrogenase
DGN16_RS14625	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS14625	COG3321	synthase
DGN16_RS14630	COG5001	Diguanylate cyclase
DGN16_RS14630	COG3706	GGDEF domain
DGN16_RS14630	COG4251	negative regulation of phosphorylation
DGN16_RS14630	COG2203	Gaf domain
DGN16_RS14635	COG0629	single-stranded DNA binding
DGN16_RS14640	COG0142	geranyltranstransferase activity
DGN16_RS14655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DGN16_RS14670	COG0527	aspartate kinase activity
DGN16_RS14675	COG0384	phenazine biosynthesis protein PhzF
DGN16_RS14680	COG0384	phenazine biosynthesis protein PhzF
DGN16_RS14690	COG1764	response to oxidative stress
DGN16_RS14695	COG0540	Belongs to the ATCase OTCase family
DGN16_RS14700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DGN16_RS14705	COG1678	Uncharacterized ACR, COG1678
DGN16_RS14710	COG0519	Catalyzes the synthesis of GMP from XMP
DGN16_RS14735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DGN16_RS14750	COG0739	heme binding
DGN16_RS14770	COG0693	protein deglycase activity
DGN16_RS14780	COG1959	2 iron, 2 sulfur cluster binding
DGN16_RS14785	COG0719	Fe-S assembly protein
DGN16_RS14790	COG0396	ATPase activity
DGN16_RS14795	COG0719	Fe-S assembly protein
DGN16_RS14800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DGN16_RS14810	COG2146	nitrite reductase [NAD(P)H] activity
DGN16_RS14815	COG4774	siderophore transport
DGN16_RS14820	COG3128	pkhd-type hydroxylase
DGN16_RS14845	COG1477	protein flavinylation
DGN16_RS14850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN16_RS14860	COG3039	Transposase
DGN16_RS14870	COG1555	photosystem II stabilization
DGN16_RS14885	COG3178	'Phosphotransferase
DGN16_RS14890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DGN16_RS14900	COG0628	permease
DGN16_RS14910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DGN16_RS14920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DGN16_RS14940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DGN16_RS14945	COG0271	Belongs to the BolA IbaG family
DGN16_RS14955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DGN16_RS14965	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DGN16_RS14970	COG1137	ATPase activity
DGN16_RS14985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN16_RS14990	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DGN16_RS14995	COG1660	Displays ATPase and GTPase activities
DGN16_RS15005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN16_RS15010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGN16_RS15015	COG2239	Acts as a magnesium transporter
DGN16_RS15025	COG1294	oxidase, subunit
DGN16_RS15030	COG1271	oxidase subunit
DGN16_RS15040	COG1113	amino acid transport
DGN16_RS15045	COG3328	transposase activity
DGN16_RS15065	COG2197	response regulator
DGN16_RS15070	COG0531	amino acid
DGN16_RS15080	COG3039	Transposase
DGN16_RS15155	COG2814	Major facilitator Superfamily
DGN16_RS15165	COG0754	glutathionylspermidine amidase activity
DGN16_RS15190	COG1842	Phage shock protein A
DGN16_RS15200	COG0259	pyridoxamine-phosphate oxidase activity
DGN16_RS15205	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DGN16_RS15210	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DGN16_RS15220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DGN16_RS15225	COG2814	Major facilitator Superfamily
DGN16_RS15245	COG2198	Histidine kinase
DGN16_RS15245	COG2205	protein histidine kinase activity
DGN16_RS15245	COG0784	Response regulator, receiver
DGN16_RS15250	COG2353	YceI-like domain
DGN16_RS15270	COG1760	l-serine dehydratase
DGN16_RS15280	COG0527	aspartate kinase activity
DGN16_RS15280	COG0460	homoserine dehydrogenase
DGN16_RS15285	COG0626	cystathionine gamma-synthase activity
DGN16_RS15290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN16_RS15295	COG0739	heme binding
DGN16_RS15300	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DGN16_RS15305	COG1272	protein, Hemolysin III
DGN16_RS15310	COG2982	Protein involved in outer membrane biogenesis
DGN16_RS15315	COG0517	IMP dehydrogenase activity
DGN16_RS15315	COG0516	GMP reductase activity
DGN16_RS15320	COG0463	Glycosyl transferase, family 2
DGN16_RS15325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGN16_RS15330	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DGN16_RS15340	COG4771	TonB-dependent receptor
DGN16_RS15345	COG3328	transposase activity
DGN16_RS15355	COG3039	Transposase
DGN16_RS15360	COG1309	transcriptional regulator
DGN16_RS15370	COG1960	acyl-CoA dehydrogenase activity
DGN16_RS15395	COG3328	transposase activity
DGN16_RS15415	COG0509	glycine decarboxylation via glycine cleavage system
DGN16_RS15420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DGN16_RS15440	COG1742	UPF0060 membrane protein
DGN16_RS15445	COG3956	TIGRFAM MazG family protein
DGN16_RS15450	COG1218	3'(2'),5'-bisphosphate nucleotidase
DGN16_RS15455	COG0494	nUDIX hydrolase
DGN16_RS15465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DGN16_RS15470	COG0837	glucose binding
DGN16_RS15485	COG1388	LysM domain
DGN16_RS15485	COG3858	chitin binding
DGN16_RS15490	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DGN16_RS15500	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN16_RS15520	COG0531	amino acid
DGN16_RS15530	COG1486	melibiose metabolic process
DGN16_RS15540	COG3537	Alpha-1,2-mannosidase
DGN16_RS15575	COG3142	Participates in the control of copper homeostasis
DGN16_RS15580	COG1446	asparaginase
DGN16_RS15600	COG2198	Histidine kinase
DGN16_RS15600	COG0784	Response regulator, receiver
DGN16_RS15600	COG0643	Histidine kinase
DGN16_RS15605	COG0840	transmembrane signaling receptor activity
DGN16_RS15610	COG0835	chemotaxis
DGN16_RS15625	COG0189	ligase activity
DGN16_RS15635	COG1397	ADP-ribosylglycohydrolase
DGN16_RS15645	COG1199	ATP-dependent helicase activity
DGN16_RS15655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGN16_RS15660	COG1215	transferase activity, transferring glycosyl groups
DGN16_RS15670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGN16_RS15680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DGN16_RS15685	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DGN16_RS15690	COG0535	radical SAM domain protein
DGN16_RS15695	COG0535	radical SAM domain protein
DGN16_RS15710	COG0837	glucose binding
DGN16_RS15720	COG1643	Atp-dependent helicase
DGN16_RS15725	COG0783	Belongs to the Dps family
DGN16_RS15730	COG0514	ATP-dependent DNA helicase (RecQ)
DGN16_RS15775	COG0840	transmembrane signaling receptor activity
DGN16_RS15795	COG3920	Histidine kinase
DGN16_RS15800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DGN16_RS15810	COG0602	queuosine metabolic process
DGN16_RS15820	COG2885	chlorophyll binding
DGN16_RS15825	COG0823	Involved in the tonB-independent uptake of proteins
DGN16_RS15835	COG0848	biopolymer transport protein
DGN16_RS15845	COG0824	Thioesterase
DGN16_RS15850	COG2255	four-way junction helicase activity
DGN16_RS15855	COG3158	transport of potassium into the cell
DGN16_RS15860	COG0632	four-way junction helicase activity
DGN16_RS15865	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DGN16_RS15870	COG0217	transcriptional regulatory protein
DGN16_RS15885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DGN16_RS15900	COG0477	Major facilitator Superfamily
DGN16_RS15940	COG0488	(ABC) transporter
DGN16_RS15970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGN16_RS15970	COG4651	solute:proton antiporter activity
DGN16_RS15980	COG4772	TonB-dependent receptor
DGN16_RS15990	COG4264	IucA IucC family
DGN16_RS16005	COG0019	diaminopimelate decarboxylase activity
DGN16_RS16030	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DGN16_RS16040	COG1492	cobalamin metabolic process
DGN16_RS16050	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGN16_RS16075	COG4206	TonB-dependent receptor
DGN16_RS16080	COG0542	response to heat
DGN16_RS16085	COG1116	anion transmembrane transporter activity
DGN16_RS16090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN16_RS16095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DGN16_RS16100	COG0667	Aldo Keto reductase
DGN16_RS16105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGN16_RS16130	COG2827	Endonuclease containing a URI domain
DGN16_RS16170	COG1877	trehalose-phosphatase activity
DGN16_RS16175	COG3387	PFAM Glycoside hydrolase 15-related
DGN16_RS16190	COG0840	transmembrane signaling receptor activity
DGN16_RS16195	COG3011	Protein conserved in bacteria
DGN16_RS16210	COG0564	pseudouridine synthase activity
DGN16_RS16215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN16_RS16225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DGN16_RS16225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGN16_RS16235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DGN16_RS16240	COG0045	succinate-CoA ligase (ADP-forming) activity
DGN16_RS16270	COG1459	type II secretion system
DGN16_RS16275	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DGN16_RS16280	COG0237	dephospho-CoA kinase activity
DGN16_RS16295	COG3039	Transposase
DGN16_RS16315	COG3039	Transposase
DGN16_RS16330	COG0745	RESPONSE REGULATOR receiver
DGN16_RS16340	COG0189	ligase activity
DGN16_RS16375	COG3039	Transposase
DGN16_RS16395	COG3328	transposase activity
DGN16_RS16405	COG3328	transposase activity
DGN16_RS16495	COG5001	Diguanylate cyclase
DGN16_RS16510	COG3039	Transposase
DGN16_RS16595	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DGN16_RS16615	COG0270	DNA (cytosine-5-)-methyltransferase activity
DGN16_RS16635	COG2003	Belongs to the UPF0758 family
DGN16_RS16670	COG3039	Transposase
DGN16_RS16765	COG2022	thiamine diphosphate biosynthetic process
DGN16_RS16770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DGN16_RS16775	COG0471	metal ion transport
DGN16_RS16775	COG3273	potassium ion transport
DGN16_RS16795	COG1970	mechanosensitive ion channel activity
DGN16_RS16805	COG1609	Transcriptional regulator
DGN16_RS16815	COG3250	beta-galactosidase activity
DGN16_RS16820	COG4948	Mandelate Racemase Muconate Lactonizing
DGN16_RS16830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGN16_RS16840	COG0308	aminopeptidase N
DGN16_RS16845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN16_RS16855	COG0529	Catalyzes the synthesis of activated sulfate
DGN16_RS16855	COG2895	sulfate adenylyltransferase (ATP) activity
DGN16_RS16860	COG0175	sulfate reduction
DGN16_RS16865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN16_RS16870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DGN16_RS16875	COG0175	sulfate reduction
DGN16_RS16880	COG3039	Transposase
DGN16_RS16900	COG2205	protein histidine kinase activity
DGN16_RS16900	COG0784	Response regulator, receiver
DGN16_RS16900	COG2198	Histidine kinase
DGN16_RS16915	COG1648	precorrin-2 dehydrogenase activity
DGN16_RS16915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGN16_RS16930	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DGN16_RS16935	COG3588	fructose-bisphosphate aldolase
DGN16_RS16940	COG0469	pyruvate kinase activity
DGN16_RS16950	COG0126	phosphoglycerate kinase activity
DGN16_RS16970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DGN16_RS16980	COG3047	cAMP biosynthetic process
DGN16_RS16985	COG3047	cAMP biosynthetic process
DGN16_RS16995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN16_RS16995	COG3453	Protein conserved in bacteria
DGN16_RS17000	COG0725	ABC transporter, periplasmic molybdate-binding protein
DGN16_RS17005	COG4149	molybdate abc transporter
DGN16_RS17010	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DGN16_RS17045	COG1376	ErfK ybiS ycfS ynhG family protein
DGN16_RS17050	COG0739	heme binding
DGN16_RS17055	COG4773	Receptor
DGN16_RS17065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DGN16_RS17070	COG1301	dicarboxylic acid transport
DGN16_RS17080	COG2304	oxidoreductase activity
DGN16_RS17100	COG0714	Associated with various cellular activities
DGN16_RS17135	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DGN16_RS17160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DGN16_RS17170	COG2721	sulfolactate sulfo-lyase activity
DGN16_RS17185	COG2271	Major facilitator Superfamily
DGN16_RS17200	COG0583	DNA-binding transcription factor activity
DGN16_RS17205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGN16_RS17220	COG1561	YicC-like family, N-terminal region
DGN16_RS17225	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DGN16_RS17235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DGN16_RS17240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DGN16_RS17255	COG0006	proline dipeptidase activity
DGN16_RS17265	COG0006	proline dipeptidase activity
DGN16_RS17270	COG3079	Belongs to the UPF0149 family
DGN16_RS17290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DGN16_RS17300	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DGN16_RS17310	COG2912	Transglutaminase-like superfamily
DGN16_RS17315	COG1773	rubredoxin
DGN16_RS17320	COG0352	thiamine-phosphate diphosphorylase activity
DGN16_RS17335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DGN16_RS17350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN16_RS17380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DGN16_RS17385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN16_RS17390	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS17400	COG0671	phosphoesterase, PA-phosphatase related
DGN16_RS17405	COG3781	membrane
DGN16_RS17415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGN16_RS17420	COG0563	adenylate kinase activity
DGN16_RS17435	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DGN16_RS17445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DGN16_RS17470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DGN16_RS17480	COG0840	transmembrane signaling receptor activity
DGN16_RS17485	COG0405	Gamma-glutamyltransferase
DGN16_RS17490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DGN16_RS17510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DGN16_RS17515	COG0473	3-isopropylmalate dehydrogenase activity
DGN16_RS17520	COG0066	3-isopropylmalate dehydratase activity
DGN16_RS17525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DGN16_RS17555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGN16_RS17560	COG1538	Outer membrane efflux protein
DGN16_RS17565	COG1519	Transferase
DGN16_RS17570	COG1560	Kdo2-lipid A biosynthetic process
DGN16_RS17595	COG0281	malic enzyme
DGN16_RS17595	COG0280	phosphate acetyltransferase
DGN16_RS17600	COG1301	dicarboxylic acid transport
DGN16_RS17625	COG0583	DNA-binding transcription factor activity
DGN16_RS17630	COG0667	Aldo Keto reductase
DGN16_RS17645	COG2197	response regulator
DGN16_RS17655	COG0642	Histidine kinase
DGN16_RS17670	COG2851	Citrate transporter
DGN16_RS17675	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS17680	COG1609	Transcriptional regulator
DGN16_RS17685	COG2211	Major facilitator Superfamily
DGN16_RS17715	COG1162	GTPase activity
DGN16_RS17720	COG0436	Aminotransferase
DGN16_RS17735	COG0726	polysaccharide deacetylase
DGN16_RS17740	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGN16_RS17755	COG3964	amidohydrolase
DGN16_RS17760	COG0402	S-adenosylhomocysteine deaminase activity
DGN16_RS17790	COG3039	Transposase
DGN16_RS17795	COG1307	EDD domain protein, DegV family
DGN16_RS17800	COG0242	peptide deformylase activity
DGN16_RS17820	COG0457	Tetratricopeptide repeat
DGN16_RS17825	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DGN16_RS17830	COG1215	transferase activity, transferring glycosyl groups
DGN16_RS17835	COG1215	transferase activity, transferring glycosyl groups
DGN16_RS17850	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DGN16_RS17895	COG2188	Transcriptional regulator
DGN16_RS17905	COG1450	Type ii and iii secretion system protein
DGN16_RS17920	COG3166	PFAM Fimbrial assembly family protein
DGN16_RS17925	COG3156	type II secretion system protein K
DGN16_RS17930	COG4795	General secretion pathway protein
DGN16_RS17935	COG2165	general secretion pathway protein
DGN16_RS17940	COG4970	Tfp pilus assembly protein FimT
DGN16_RS17945	COG2165	general secretion pathway protein
DGN16_RS17950	COG1459	type II secretion system
DGN16_RS17955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGN16_RS17960	COG1404	Belongs to the peptidase S8 family
DGN16_RS17970	COG1404	Belongs to the peptidase S8 family
DGN16_RS17975	COG5295	Hep Hag repeat protein
DGN16_RS17980	COG0047	phosphoribosylformylglycinamidine synthase activity
DGN16_RS17980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DGN16_RS17985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGN16_RS17990	COG4974	Belongs to the 'phage' integrase family
DGN16_RS18005	COG0795	lipopolysaccharide-transporting ATPase activity
DGN16_RS18015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGN16_RS18040	COG0525	valine-tRNA ligase activity
DGN16_RS18060	COG3328	transposase activity
DGN16_RS18085	COG1183	phosphatidylcholine synthase activity
DGN16_RS18095	COG0442	prolyl-tRNA aminoacylation
DGN16_RS18110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGN16_RS18115	COG1127	ABC transporter
DGN16_RS18120	COG3218	ABC-type transport auxiliary lipoprotein component
DGN16_RS18120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGN16_RS18150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGN16_RS18155	COG0662	Cupin 2, conserved barrel domain protein
DGN16_RS18155	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DGN16_RS18185	COG2086	electron transfer activity
DGN16_RS18200	COG0463	Glycosyl transferase, family 2
DGN16_RS18220	COG2813	Specifically methylates the guanine in position
DGN16_RS18235	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DGN16_RS18240	COG0438	transferase activity, transferring glycosyl groups
DGN16_RS18260	COG0438	transferase activity, transferring glycosyl groups
DGN16_RS18265	COG0626	cystathionine gamma-synthase activity
DGN16_RS18295	COG0625	glutathione transferase activity
DGN16_RS18305	COG0513	Belongs to the DEAD box helicase family
DGN16_RS18315	COG4771	TonB-dependent receptor
DGN16_RS18320	COG0720	synthase
DGN16_RS18345	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DGN16_RS18355	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DGN16_RS18360	COG1956	GAF domain-containing protein
DGN16_RS18370	COG2819	hydrolase of the alpha beta superfamily
DGN16_RS18380	COG0546	phosphoglycolate phosphatase activity
DGN16_RS18385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DGN16_RS18390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGN16_RS18405	COG0339	signal peptide processing
DGN16_RS18455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGN16_RS18460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_RS18465	COG1136	(ABC) transporter
DGN16_RS18470	COG0577	efflux transmembrane transporter activity
DGN16_RS18505	COG4191	Histidine kinase
DGN16_RS18510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DGN16_RS18525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DGN16_RS18530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DGN16_RS18535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DGN16_RS18540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DGN16_RS18545	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DGN16_RS18550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DGN16_RS18560	COG0356	it plays a direct role in the translocation of protons across the membrane
DGN16_RS18580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGN16_RS18590	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGN16_RS18625	COG2011	ABC-type metal ion transport system permease component
DGN16_RS18630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DGN16_RS18635	COG0697	spore germination
DGN16_RS18640	COG1666	GTP binding
DGN16_RS18650	COG5002	protein histidine kinase activity
DGN16_RS18650	COG0784	Response regulator, receiver
DGN16_RS18650	COG2198	Histidine kinase
DGN16_RS18675	COG1187	pseudouridine synthase activity
DGN16_RS18680	COG2813	Specifically methylates the guanine in position
DGN16_RS18700	COG2202	Pas domain
DGN16_RS18700	COG2205	protein histidine kinase activity
DGN16_RS18720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DGN16_RS18725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN16_RS18780	COG0842	Transport permease protein
DGN16_RS18785	COG1131	(ABC) transporter
DGN16_RS18790	COG0025	NhaP-type Na H and K H
DGN16_RS18795	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DGN16_RS18800	COG1573	uracil-dna glycosylase
DGN16_RS18810	COG3384	dioxygenase
DGN16_RS18820	COG0583	DNA-binding transcription factor activity
DGN16_RS18830	COG0667	Aldo Keto reductase
DGN16_RS18840	COG3590	peptidase
DGN16_RS18855	COG0531	amino acid
DGN16_RS18870	COG2972	Histidine kinase
DGN16_RS18885	COG3685	Protein conserved in bacteria
DGN16_RS18890	COG3546	catalase activity
DGN16_RS18925	COG2204	response regulator
DGN16_RS18935	COG1271	oxidase subunit
DGN16_RS18940	COG1294	oxidase, subunit
DGN16_RS18955	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS18960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DGN16_RS18980	COG1132	(ABC) transporter
DGN16_RS18995	COG1063	alcohol dehydrogenase
DGN16_RS19070	COG0251	oxidation-reduction process
DGN16_RS19085	COG0840	transmembrane signaling receptor activity
DGN16_RS19100	COG0583	DNA-binding transcription factor activity
DGN16_RS19105	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DGN16_RS19135	COG0659	secondary active sulfate transmembrane transporter activity
DGN16_RS19145	COG0024	Methionine aminopeptidase
DGN16_RS19190	COG3039	Transposase
DGN16_RS19255	COG0582	viral genome integration into host DNA
DGN16_RS19270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGN16_RS19275	COG1490	D-aminoacyl-tRNA deacylase activity
DGN16_RS19280	COG1560	Kdo2-lipid A biosynthetic process
DGN16_RS19330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DGN16_RS19330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGN16_RS19335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DGN16_RS19340	COG0242	peptide deformylase activity
DGN16_RS19345	COG1652	LysM domain
DGN16_RS19350	COG0758	DNA mediated transformation
DGN16_RS19370	COG1754	DNA topoisomerase type I activity
DGN16_RS19370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGN16_RS19375	COG0009	L-threonylcarbamoyladenylate synthase
DGN16_RS19390	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS19400	COG0616	signal peptide processing
DGN16_RS19405	COG0534	Mate efflux family protein
DGN16_RS19425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DGN16_RS19430	COG0625	glutathione transferase activity
DGN16_RS19445	COG1252	NADH dehydrogenase
DGN16_RS19455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGN16_RS19460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DGN16_RS19465	COG2201	protein-glutamate methylesterase activity
DGN16_RS19470	COG2177	Part of the ABC transporter FtsEX involved in
DGN16_RS19475	COG2884	Cell division ATP-binding protein ftsE
DGN16_RS19480	COG0513	Belongs to the DEAD box helicase family
DGN16_RS19485	COG3118	belongs to the thioredoxin family
DGN16_RS19490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DGN16_RS19495	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DGN16_RS19500	COG0583	DNA-binding transcription factor activity
DGN16_RS19520	COG1652	LysM domain
DGN16_RS19525	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGN16_RS19525	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGN16_RS19530	COG1473	amidohydrolase
DGN16_RS19535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_RS19540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN16_RS19560	COG5383	Protein conserved in bacteria
DGN16_RS19600	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DGN16_RS19605	COG3023	N-Acetylmuramoyl-L-alanine amidase
DGN16_RS19615	COG4948	Mandelate Racemase Muconate Lactonizing
DGN16_RS19625	COG0531	amino acid
DGN16_RS19650	COG3328	transposase activity
DGN16_RS19660	COG2133	pyrroloquinoline quinone binding
DGN16_RS19670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DGN16_RS19675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DGN16_RS19685	COG1610	YqeY-like protein
DGN16_RS19690	COG1295	ribonuclease BN
DGN16_RS19695	COG0358	DNA primase activity
DGN16_RS19710	COG0109	protoheme IX farnesyltransferase activity
DGN16_RS19740	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DGN16_RS19755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DGN16_RS19795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DGN16_RS19800	COG0739	heme binding
DGN16_RS19805	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DGN16_RS19815	COG2223	nitrite transmembrane transporter activity
DGN16_RS19820	COG0708	Exodeoxyribonuclease III
DGN16_RS19825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DGN16_RS19835	COG1192	Involved in chromosome partitioning
DGN16_RS19840	COG1475	DNA binding
DGN16_RS19855	COG0463	Glycosyl transferase, family 2
DGN16_RS19870	COG0756	dUTP diphosphatase activity
DGN16_RS19875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DGN16_RS19880	COG2003	Belongs to the UPF0758 family
DGN16_RS19885	COG0018	arginyl-trna synthetase
DGN16_RS19900	COG4221	oxidoreductase activity
DGN16_RS19905	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DGN16_RS19905	COG2755	lipolytic protein G-D-S-L family
DGN16_RS19920	COG1166	arginine decarboxylase activity
DGN16_RS19925	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DGN16_RS19945	COG3291	Pkd domain containing protein
DGN16_RS19945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DGN16_RS19960	COG0606	chelatase, subunit chli
DGN16_RS19975	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DGN16_RS19995	COG3039	Transposase
DGN16_RS20005	COG1690	Belongs to the RtcB family
DGN16_RS20045	COG1090	epimerase
DGN16_RS20055	COG0642	Histidine kinase
DGN16_RS20075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGN16_RS20100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DGN16_RS20105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGN16_RS20110	COG3328	transposase activity
DGN16_RS20120	COG0753	catalase activity
DGN16_RS20135	COG2197	response regulator
DGN16_RS20140	COG4585	Histidine kinase
DGN16_RS20145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_RS20150	COG1136	(ABC) transporter
DGN16_RS20175	COG0697	spore germination
DGN16_RS20195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN16_RS20200	COG0180	Tryptophanyl-tRNA synthetase
DGN16_RS20205	COG3237	CsbD-like
DGN16_RS20245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DGN16_RS20265	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DGN16_RS20310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGN16_RS20330	COG1199	ATP-dependent helicase activity
DGN16_RS20345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DGN16_RS20415	COG0625	glutathione transferase activity
DGN16_RS20460	COG4555	ABC transporter
DGN16_RS20470	COG1476	TRANSCRIPTIONal
DGN16_RS20490	COG1230	cation diffusion facilitator family transporter
DGN16_RS20500	COG4774	siderophore transport
DGN16_RS20515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN16_RS20520	COG1131	(ABC) transporter
DGN16_RS20525	COG0842	Transport permease protein
DGN16_RS20530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DGN16_RS20560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGN16_RS20565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGN16_RS20575	COG0045	succinate-CoA ligase (ADP-forming) activity
DGN16_RS20575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DGN16_RS20575	COG1042	CoA-binding domain protein
DGN16_RS20580	COG2239	Acts as a magnesium transporter
DGN16_RS20595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGN16_RS20600	COG3387	PFAM Glycoside hydrolase 15-related
DGN16_RS20615	COG3100	YcgL domain-containing protein
DGN16_RS20620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGN16_RS20630	COG0463	Glycosyl transferase, family 2
DGN16_RS20640	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS20690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN16_RS20715	COG0823	Involved in the tonB-independent uptake of proteins
DGN16_RS20715	COG1506	peptidase
DGN16_RS20715	COG4946	Tricorn protease homolog
DGN16_RS20735	COG0408	coproporphyrinogen oxidase activity
DGN16_RS20770	COG0515	serine threonine protein kinase
DGN16_RS20835	COG1595	DNA-templated transcription, initiation
DGN16_RS20880	COG3039	Transposase
DGN16_RS20950	COG0210	DNA helicase
DGN16_RS20960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN16_RS20965	COG0583	DNA-binding transcription factor activity
DGN16_RS20970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGN16_RS21000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_RS21020	COG0357	Ribosomal RNA small subunit methyltransferase G
DGN16_RS21025	COG3540	Alkaline phosphatase
DGN16_RS21050	COG0708	Exodeoxyribonuclease III
DGN16_RS21055	COG1846	Transcriptional regulator
DGN16_RS21055	COG1940	carbohydrate kinase activity
DGN16_RS21065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN16_RS21075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DGN16_RS21080	COG3162	membrane
DGN16_RS21090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DGN16_RS21135	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS21140	COG0179	Fumarylacetoacetate (FAA) hydrolase
DGN16_RS21145	COG4948	Mandelate Racemase Muconate Lactonizing
DGN16_RS21150	COG3254	rhamnose metabolic process
DGN16_RS21155	COG0738	Major facilitator superfamily
DGN16_RS21160	COG1414	Transcriptional regulator
DGN16_RS21165	COG1971	Probably functions as a manganese efflux pump
DGN16_RS21170	COG2205	protein histidine kinase activity
DGN16_RS21180	COG3459	Glycosyltransferase 36 associated
DGN16_RS21185	COG2211	Major facilitator Superfamily
DGN16_RS21190	COG3265	gluconokinase activity
DGN16_RS21195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN16_RS21220	COG2911	Protein conserved in bacteria
DGN16_RS21225	COG0729	surface antigen
DGN16_RS21235	COG3039	Transposase
DGN16_RS21240	COG3039	Transposase
DGN16_RS21245	COG3039	Transposase
DGN16_RS21280	COG0752	glycyl-tRNA synthetase alpha subunit
DGN16_RS21285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGN16_RS21300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGN16_RS21300	COG0519	Catalyzes the synthesis of GMP from XMP
DGN16_RS21310	COG0805	protein transport
DGN16_RS21315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGN16_RS21320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGN16_RS21330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DGN16_RS21350	COG2974	May be involved in recombination
DGN16_RS21355	COG0037	tRNA processing
DGN16_RS21360	COG2115	Belongs to the xylose isomerase family
DGN16_RS21370	COG3661	Belongs to the glycosyl hydrolase 67 family
DGN16_RS21380	COG4948	Mandelate Racemase Muconate Lactonizing
DGN16_RS21390	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN16_RS21395	COG0246	Mannitol dehydrogenase
DGN16_RS21465	COG3386	PFAM SMP-30 Gluconolaconase
DGN16_RS21475	COG3250	beta-galactosidase activity
DGN16_RS21480	COG1904	glucuronate isomerase
DGN16_RS21500	COG3693	PFAM glycoside hydrolase, family 10
DGN16_RS21515	COG2211	Major facilitator Superfamily
DGN16_RS21550	COG3321	synthase
DGN16_RS21550	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS21550	COG0604	alcohol dehydrogenase
DGN16_RS21555	COG2937	Belongs to the GPAT DAPAT family
DGN16_RS21585	COG3039	Transposase
DGN16_RS21590	COG0284	orotidine-5'-phosphate decarboxylase activity
DGN16_RS21595	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DGN16_RS21600	COG3132	Protein of unknown function, DUF480
DGN16_RS21625	COG0210	DNA helicase
DGN16_RS21630	COG1435	thymidine kinase activity
DGN16_RS21640	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DGN16_RS21650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DGN16_RS21680	COG3135	benzoate transporter
DGN16_RS21700	COG0676	glucose-6-phosphate 1-epimerase activity
DGN16_RS21710	COG3012	SEC-C Motif Domain Protein
DGN16_RS21715	COG0730	response to heat
DGN16_RS21740	COG0302	gtp cyclohydrolase
DGN16_RS21755	COG1566	PFAM secretion protein HlyD family protein
DGN16_RS21765	COG1289	transmembrane transporter activity
DGN16_RS21770	COG0477	Major facilitator Superfamily
DGN16_RS21780	COG0583	DNA-binding transcription factor activity
DGN16_RS21785	COG4221	oxidoreductase activity
DGN16_RS21795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN16_RS21835	COG3328	transposase activity
DGN16_RS21860	COG0564	pseudouridine synthase activity
DGN16_RS21875	COG3039	Transposase
DGN16_RS21895	COG3039	Transposase
DGN16_RS21900	COG3039	Transposase
DGN16_RS21920	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS21945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DGN16_RS21950	COG1074	ATP-dependent DNA helicase activity
DGN16_RS21955	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DGN16_RS21990	COG1127	ABC transporter
DGN16_RS21995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGN16_RS22000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGN16_RS22015	COG2853	Lipoprotein
DGN16_RS22025	COG0386	Belongs to the glutathione peroxidase family
DGN16_RS22050	COG0625	glutathione transferase activity
DGN16_RS22185	COG1196	nuclear chromosome segregation
DGN16_RS22200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN16_RS22220	COG2948	multi-organism process
DGN16_RS22225	COG3504	Conjugal transfer protein
DGN16_RS22275	COG3328	transposase activity
DGN16_RS22300	COG1192	Involved in chromosome partitioning
DGN16_RS22320	COG3537	Alpha-1,2-mannosidase
DGN16_RS22340	COG1929	Belongs to the glycerate kinase type-1 family
DGN16_RS22345	COG2271	Major facilitator Superfamily
DGN16_RS22360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGN16_RS22365	COG0861	Integral membrane protein TerC family
DGN16_RS22375	COG0584	glycerophosphoryl diester phosphodiesterase
DGN16_RS22385	COG3039	Transposase
DGN16_RS22395	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DGN16_RS22405	COG0706	membrane insertase activity
DGN16_RS22410	COG0594	ribonuclease P activity
DGN16_RS22490	COG3328	transposase activity
DGN16_RS22515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DGN16_RS22520	COG4691	Plasmid stability protein
DGN16_RS22525	COG1487	ribonuclease activity
DGN16_RS22540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGN16_RS22555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGN16_RS22760	COG3328	transposase activity
DGN16_RS22765	COG3328	transposase activity
DGN16_RS22790	COG3328	transposase activity
DGN16_RS22840	COG2951	lytic endotransglycosylase activity
DGN16_RS23015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN16_RS23015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN16_RS23015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN16_RS23015	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS23015	COG3321	synthase
DGN16_RS23075	COG2813	Specifically methylates the guanine in position
DGN16_RS23185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DGN16_RS23200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN16_RS23200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN16_RS23200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN16_RS23200	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS23200	COG3321	synthase
DGN16_RS23200	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_RS23200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN16_RS23200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN16_RS23200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN16_RS23200	COG3321	synthase