locus-tag	class	description
FPL03_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FPL03_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FPL03_RS00025	COG0187	DNA topoisomerase II activity
FPL03_RS00035	COG0501	Belongs to the peptidase M48B family
FPL03_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FPL03_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL03_RS00120	COG0793	Belongs to the peptidase S41A family
FPL03_RS00125	COG4942	peptidase
FPL03_RS00135	COG2234	aminopeptidase activity
FPL03_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL03_RS00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL03_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL03_RS00170	COG1064	alcohol dehydrogenase
FPL03_RS00180	COG0493	'glutamate synthase
FPL03_RS00185	COG0067	glutamate synthase
FPL03_RS00185	COG0070	glutamate synthase
FPL03_RS00185	COG0069	glutamate synthase activity
FPL03_RS00235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FPL03_RS00250	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FPL03_RS00255	COG0297	glycogen (starch) synthase activity
FPL03_RS00255	COG0438	transferase activity, transferring glycosyl groups
FPL03_RS00275	COG0367	asparagine synthase
FPL03_RS00305	COG1132	(ABC) transporter
FPL03_RS00335	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FPL03_RS00430	COG1205	dead DEAH box helicase
FPL03_RS00430	COG1111	helicase
FPL03_RS00435	COG1272	protein, Hemolysin III
FPL03_RS00460	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS00485	COG2249	NAD(P)H dehydrogenase (quinone) activity
FPL03_RS00495	COG3237	CsbD-like
FPL03_RS00540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL03_RS00550	COG0477	Major facilitator Superfamily
FPL03_RS00590	COG0714	Associated with various cellular activities
FPL03_RS00620	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FPL03_RS00630	COG4772	TonB-dependent receptor
FPL03_RS00640	COG0662	Cupin 2, conserved barrel domain protein
FPL03_RS00645	COG1012	belongs to the aldehyde dehydrogenase family
FPL03_RS00670	COG1304	FMN binding
FPL03_RS00685	COG4585	Histidine kinase
FPL03_RS00690	COG2197	response regulator
FPL03_RS00710	COG3710	Transcriptional regulator
FPL03_RS00715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FPL03_RS00750	COG2131	deaminase
FPL03_RS00800	COG0366	Alpha amylase catalytic
FPL03_RS00805	COG0366	Alpha amylase catalytic
FPL03_RS00810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL03_RS00830	COG2755	lipolytic protein G-D-S-L family
FPL03_RS00830	COG0657	acetylesterase activity
FPL03_RS00840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FPL03_RS00855	COG3507	Belongs to the glycosyl hydrolase 43 family
FPL03_RS00860	COG1609	Transcriptional regulator
FPL03_RS00880	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FPL03_RS00885	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS00895	COG2755	lipolytic protein G-D-S-L family
FPL03_RS00910	COG3186	Phenylalanine-4-hydroxylase
FPL03_RS00915	COG1522	sequence-specific DNA binding
FPL03_RS00925	COG1752	Esterase of the alpha-beta hydrolase superfamily
FPL03_RS00935	COG1119	ATPase activity
FPL03_RS00950	COG1125	glycine betaine transport
FPL03_RS00965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FPL03_RS00985	COG3550	peptidyl-serine autophosphorylation
FPL03_RS00990	COG1396	sequence-specific DNA binding
FPL03_RS01015	COG0489	protein tyrosine kinase activity
FPL03_RS01020	COG2062	phosphohistidine phosphatase, SixA
FPL03_RS01030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL03_RS01080	COG1968	undecaprenyl-diphosphatase activity
FPL03_RS01090	COG0174	glutamine synthetase
FPL03_RS01095	COG0347	Belongs to the P(II) protein family
FPL03_RS01100	COG0004	ammonium transporteR
FPL03_RS01105	COG3852	Histidine kinase
FPL03_RS01110	COG2204	response regulator
FPL03_RS01115	COG2032	superoxide dismutase activity
FPL03_RS01120	COG2032	superoxide dismutase activity
FPL03_RS01130	COG0346	lactoylglutathione lyase activity
FPL03_RS01140	COG0183	Belongs to the thiolase family
FPL03_RS01175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FPL03_RS01180	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FPL03_RS01185	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FPL03_RS01240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FPL03_RS01245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FPL03_RS01250	COG4786	Flagellar basal body rod
FPL03_RS01255	COG4786	Flagellar basal body rod
FPL03_RS01265	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FPL03_RS01270	COG1706	bacterial-type flagellum-dependent cell motility
FPL03_RS01285	COG1677	Flagellar hook-basal body complex protein FliE
FPL03_RS01320	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FPL03_RS01355	COG0028	Belongs to the TPP enzyme family
FPL03_RS01360	COG2205	protein histidine kinase activity
FPL03_RS01385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FPL03_RS01400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL03_RS01410	COG0596	Alpha beta hydrolase
FPL03_RS01415	COG0727	PFAM Uncharacterised protein family (UPF0153)
FPL03_RS01420	COG0318	PFAM AMP-dependent synthetase and ligase
FPL03_RS01425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL03_RS01450	COG1181	Belongs to the D-alanine--D-alanine ligase family
FPL03_RS01460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPL03_RS01470	COG0564	pseudouridine synthase activity
FPL03_RS01490	COG1446	asparaginase
FPL03_RS01495	COG0339	signal peptide processing
FPL03_RS01530	COG0475	glutathione-regulated potassium exporter activity
FPL03_RS01535	COG0583	DNA-binding transcription factor activity
FPL03_RS01540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FPL03_RS01545	COG2224	Isocitrate lyase
FPL03_RS01575	COG4770	biotin carboxylase activity
FPL03_RS01580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FPL03_RS01585	COG1960	acyl-CoA dehydrogenase activity
FPL03_RS01640	COG0523	cobalamin synthesis protein
FPL03_RS01650	COG0697	spore germination
FPL03_RS01660	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FPL03_RS01665	COG1846	Transcriptional regulator
FPL03_RS01670	COG1764	response to oxidative stress
FPL03_RS01700	COG2130	NADP-dependent
FPL03_RS01715	COG1187	pseudouridine synthase activity
FPL03_RS01730	COG1643	Atp-dependent helicase
FPL03_RS01740	COG4807	Protein conserved in bacteria
FPL03_RS01745	COG2351	hydroxyisourate hydrolase activity
FPL03_RS01750	COG2072	flavoprotein involved in K transport
FPL03_RS01770	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FPL03_RS01805	COG1957	nucleoside hydrolase
FPL03_RS01815	COG2252	PERMEase
FPL03_RS01840	COG0084	hydrolase, TatD family'
FPL03_RS01855	COG0583	DNA-binding transcription factor activity
FPL03_RS01860	COG2814	Major facilitator Superfamily
FPL03_RS01875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FPL03_RS01880	COG1902	pentaerythritol trinitrate reductase activity
FPL03_RS01900	COG0745	RESPONSE REGULATOR receiver
FPL03_RS01905	COG2205	protein histidine kinase activity
FPL03_RS01910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL03_RS01935	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FPL03_RS01940	COG0583	DNA-binding transcription factor activity
FPL03_RS01975	COG0702	epimerase
FPL03_RS01980	COG1733	regulation of RNA biosynthetic process
FPL03_RS02040	COG0129	dihydroxy-acid dehydratase activity
FPL03_RS02055	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FPL03_RS02115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FPL03_RS02120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FPL03_RS02145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FPL03_RS02150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FPL03_RS02160	COG3485	protocatechuate 3,4-dioxygenase
FPL03_RS02165	COG3485	protocatechuate 3,4-dioxygenase
FPL03_RS02175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL03_RS02180	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FPL03_RS02195	COG1414	Transcriptional regulator
FPL03_RS02205	COG0657	acetylesterase activity
FPL03_RS02215	COG0445	tRNA wobble uridine modification
FPL03_RS02225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FPL03_RS02255	COG2267	carboxylic ester hydrolase activity
FPL03_RS02265	COG0156	8-amino-7-oxononanoate synthase activity
FPL03_RS02270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FPL03_RS02275	COG1040	competence protein
FPL03_RS02280	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FPL03_RS02370	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FPL03_RS02455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPL03_RS02465	COG2354	Protein conserved in bacteria
FPL03_RS02475	COG0297	glycogen (starch) synthase activity
FPL03_RS02480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL03_RS02485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL03_RS02510	COG0702	epimerase
FPL03_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS02540	COG0513	Belongs to the DEAD box helicase family
FPL03_RS02545	COG0508	dehydrogenase complex catalyzes the overall conversion of
FPL03_RS02560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FPL03_RS02570	COG3483	tryptophan 2,3-dioxygenase activity
FPL03_RS02575	COG3104	oligopeptide transport
FPL03_RS02595	COG2852	Protein conserved in bacteria
FPL03_RS02600	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FPL03_RS02620	COG1320	monovalent cation:proton antiporter activity
FPL03_RS02625	COG2212	antiporter activity
FPL03_RS02635	COG0651	ATP synthesis coupled electron transport
FPL03_RS02640	COG1006	Multisubunit Na H antiporter MnhC subunit
FPL03_RS02645	COG2111	Na H antiporter
FPL03_RS02645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FPL03_RS02670	COG3179	chitinase
FPL03_RS02690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FPL03_RS02695	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FPL03_RS02710	COG0456	acetyltransferase
FPL03_RS02715	COG1597	lipid kinase activity
FPL03_RS02745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FPL03_RS02750	COG0134	indole-3-glycerol-phosphate synthase activity
FPL03_RS02760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL03_RS02765	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FPL03_RS02775	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FPL03_RS02785	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FPL03_RS02800	COG1051	belongs to the nudix hydrolase family
FPL03_RS02840	COG0316	Belongs to the HesB IscA family
FPL03_RS02860	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FPL03_RS02875	COG2814	Major facilitator Superfamily
FPL03_RS02885	COG2814	Major facilitator Superfamily
FPL03_RS02890	COG1289	transmembrane transporter activity
FPL03_RS02900	COG0151	Belongs to the GarS family
FPL03_RS02910	COG0138	bifunctional purine biosynthesis protein purh
FPL03_RS02915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FPL03_RS02920	COG2267	carboxylic ester hydrolase activity
FPL03_RS02925	COG0671	phosphoesterase, PA-phosphatase related
FPL03_RS02925	COG2453	phosphatase
FPL03_RS02950	COG4589	Belongs to the CDS family
FPL03_RS02955	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FPL03_RS02985	COG2264	protein methyltransferase activity
FPL03_RS03010	COG0439	Biotin carboxylase
FPL03_RS03020	COG0511	ligase activity, forming carbon-carbon bonds
FPL03_RS03025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FPL03_RS03035	COG1324	tolerance protein
FPL03_RS03065	COG0300	oxidoreductase activity
FPL03_RS03070	COG2356	endonuclease I
FPL03_RS03085	COG0459	protein refolding
FPL03_RS03100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FPL03_RS03115	COG3386	PFAM SMP-30 Gluconolaconase
FPL03_RS03125	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FPL03_RS03130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FPL03_RS03150	COG0778	Nitroreductase
FPL03_RS03155	COG2353	YceI-like domain
FPL03_RS03185	COG3052	prosthetic group binding
FPL03_RS03220	COG1802	Transcriptional regulator
FPL03_RS03350	COG4221	oxidoreductase activity
FPL03_RS03365	COG4221	oxidoreductase activity
FPL03_RS03375	COG0435	Glutathione S-transferase
FPL03_RS03395	COG2409	Drug exporters of the RND superfamily
FPL03_RS03405	COG0823	Involved in the tonB-independent uptake of proteins
FPL03_RS03405	COG1506	peptidase
FPL03_RS03450	COG0697	spore germination
FPL03_RS03465	COG1113	amino acid transport
FPL03_RS03485	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FPL03_RS03530	COG5001	Diguanylate cyclase
FPL03_RS03535	COG0840	transmembrane signaling receptor activity
FPL03_RS03540	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL03_RS03540	COG5297	Belongs to the glycosyl hydrolase family 6
FPL03_RS03545	COG0659	secondary active sulfate transmembrane transporter activity
FPL03_RS03575	COG2943	transferase activity, transferring hexosyl groups
FPL03_RS03585	COG3275	phosphorelay sensor kinase activity
FPL03_RS03595	COG0181	hydroxymethylbilane synthase activity
FPL03_RS03625	COG1505	serine-type exopeptidase activity
FPL03_RS03635	COG0436	Aminotransferase
FPL03_RS03645	COG2832	Protein of unknown function (DUF454)
FPL03_RS03655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FPL03_RS03665	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FPL03_RS03670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FPL03_RS03675	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FPL03_RS03700	COG2226	methyltransferase
FPL03_RS03705	COG5001	Diguanylate cyclase
FPL03_RS03705	COG3300	MHYT domain
FPL03_RS03710	COG0308	aminopeptidase N
FPL03_RS03760	COG3284	Transcriptional regulator
FPL03_RS03765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPL03_RS03770	COG1077	Cell shape determining protein MreB Mrl
FPL03_RS03775	COG1792	Involved in formation and maintenance of cell shape
FPL03_RS03790	COG0772	Belongs to the SEDS family
FPL03_RS03800	COG2951	lytic endotransglycosylase activity
FPL03_RS03805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FPL03_RS03815	COG1686	Belongs to the peptidase S11 family
FPL03_RS03825	COG2921	Belongs to the UPF0250 family
FPL03_RS03830	COG0321	lipoyl(octanoyl) transferase activity
FPL03_RS03835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FPL03_RS03850	COG0583	DNA-binding transcription factor activity
FPL03_RS03860	COG1051	belongs to the nudix hydrolase family
FPL03_RS03860	COG1056	cytidyltransferase-related domain
FPL03_RS03895	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FPL03_RS03900	COG0673	inositol 2-dehydrogenase activity
FPL03_RS03905	COG2823	Periplasmic or secreted lipoprotein
FPL03_RS03910	COG4251	negative regulation of phosphorylation
FPL03_RS03915	COG0784	Response regulator, receiver
FPL03_RS03920	COG4191	Histidine kinase
FPL03_RS03925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FPL03_RS03985	COG1459	type II secretion system
FPL03_RS04005	COG4795	General secretion pathway protein
FPL03_RS04035	COG3250	beta-galactosidase activity
FPL03_RS04050	COG2188	Transcriptional regulator
FPL03_RS04060	COG1609	Transcriptional regulator
FPL03_RS04065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPL03_RS04070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FPL03_RS04080	COG0617	tRNA 3'-terminal CCA addition
FPL03_RS04085	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FPL03_RS04090	COG1012	belongs to the aldehyde dehydrogenase family
FPL03_RS04095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FPL03_RS04110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL03_RS04125	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FPL03_RS04130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FPL03_RS04150	COG2205	protein histidine kinase activity
FPL03_RS04180	COG3791	Glutathione-dependent formaldehyde-activating
FPL03_RS04195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL03_RS04215	COG0488	(ABC) transporter
FPL03_RS04225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FPL03_RS04230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FPL03_RS04240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPL03_RS04240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPL03_RS04260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FPL03_RS04265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FPL03_RS04270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FPL03_RS04295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FPL03_RS04300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FPL03_RS04305	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FPL03_RS04310	COG2205	protein histidine kinase activity
FPL03_RS04315	COG0745	RESPONSE REGULATOR receiver
FPL03_RS04330	COG0277	FAD linked oxidase domain protein
FPL03_RS04335	COG1988	membrane-bound metal-dependent
FPL03_RS04340	COG0792	nuclease activity
FPL03_RS04380	COG0275	rRNA processing
FPL03_RS04385	COG3116	cell division
FPL03_RS04395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FPL03_RS04400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FPL03_RS04405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FPL03_RS04415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FPL03_RS04420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPL03_RS04425	COG1181	Belongs to the D-alanine--D-alanine ligase family
FPL03_RS04430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FPL03_RS04445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FPL03_RS04455	COG0739	heme binding
FPL03_RS04460	COG0653	protein targeting
FPL03_RS04465	COG0494	nUDIX hydrolase
FPL03_RS04475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FPL03_RS04490	COG3321	synthase
FPL03_RS04490	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS04490	COG0604	alcohol dehydrogenase
FPL03_RS04525	COG0366	Alpha amylase catalytic
FPL03_RS04550	COG2226	methyltransferase
FPL03_RS04555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FPL03_RS04565	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FPL03_RS04605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FPL03_RS04615	COG4106	trans-aconitate 2-methyltransferase activity
FPL03_RS04620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPL03_RS04630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPL03_RS04635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FPL03_RS04645	COG0667	Aldo Keto reductase
FPL03_RS04655	COG4771	TonB-dependent receptor
FPL03_RS04675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL03_RS04680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FPL03_RS04690	COG2175	clavaminate synthase activity
FPL03_RS04700	COG4181	ATPase activity
FPL03_RS04715	COG0642	Histidine kinase
FPL03_RS04725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FPL03_RS04745	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FPL03_RS04750	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FPL03_RS04765	COG3829	transcription factor binding
FPL03_RS04775	COG1116	anion transmembrane transporter activity
FPL03_RS04780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL03_RS04790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL03_RS04795	COG0431	NADPH-dependent FMN reductase
FPL03_RS04820	COG0747	negative chemotaxis
FPL03_RS04830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FPL03_RS04840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FPL03_RS04845	COG2967	ApaG domain
FPL03_RS04850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FPL03_RS04855	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FPL03_RS04860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL03_RS04865	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FPL03_RS04870	COG0123	including yeast histone deacetylase and acetoin utilization protein
FPL03_RS04875	COG2096	Adenosyltransferase
FPL03_RS04890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL03_RS04895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL03_RS04925	COG3384	dioxygenase
FPL03_RS04930	COG0583	DNA-binding transcription factor activity
FPL03_RS04945	COG1024	Enoyl-CoA hydratase
FPL03_RS04965	COG3386	PFAM SMP-30 Gluconolaconase
FPL03_RS04980	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FPL03_RS05000	COG0697	spore germination
FPL03_RS05010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL03_RS05035	COG2197	response regulator
FPL03_RS05045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FPL03_RS05055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FPL03_RS05060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL03_RS05070	COG0583	DNA-binding transcription factor activity
FPL03_RS05075	COG3634	alkyl hydroperoxide reductase activity
FPL03_RS05085	COG2890	protein-(glutamine-N5) methyltransferase activity
FPL03_RS05105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL03_RS05105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL03_RS05135	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FPL03_RS05160	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FPL03_RS05175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FPL03_RS05185	COG1404	Belongs to the peptidase S8 family
FPL03_RS05190	COG1404	Belongs to the peptidase S8 family
FPL03_RS05195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FPL03_RS05220	COG1295	ribonuclease BN
FPL03_RS05225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL03_RS05230	COG1254	Belongs to the acylphosphatase family
FPL03_RS05245	COG0521	Mo-molybdopterin cofactor biosynthetic process
FPL03_RS05255	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FPL03_RS05260	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FPL03_RS05270	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FPL03_RS05275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FPL03_RS05285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FPL03_RS05290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FPL03_RS05295	COG0193	aminoacyl-tRNA hydrolase activity
FPL03_RS05300	COG0012	GTP binding
FPL03_RS05320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FPL03_RS05335	COG0250	Participates in transcription elongation, termination and antitermination
FPL03_RS05340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FPL03_RS05345	COG0081	regulation of translation
FPL03_RS05350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FPL03_RS05355	COG0222	ribosome binding
FPL03_RS05360	COG0085	RNA polymerase activity
FPL03_RS05365	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FPL03_RS05370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FPL03_RS05375	COG0049	tRNA binding
FPL03_RS05380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FPL03_RS05385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FPL03_RS05390	COG0051	transcription antitermination factor activity, RNA binding
FPL03_RS05395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FPL03_RS05400	COG0088	Forms part of the polypeptide exit tunnel
FPL03_RS05405	COG0089	rRNA binding
FPL03_RS05410	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FPL03_RS05415	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FPL03_RS05425	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FPL03_RS05430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FPL03_RS05435	COG0255	Belongs to the universal ribosomal protein uL29 family
FPL03_RS05440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FPL03_RS05450	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FPL03_RS05455	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FPL03_RS05465	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FPL03_RS05470	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FPL03_RS05475	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FPL03_RS05485	COG1841	ribosomal large subunit assembly
FPL03_RS05490	COG0200	Binds to the 23S rRNA
FPL03_RS05495	COG0201	protein transport
FPL03_RS05520	COG0203	ribosomal protein L17
FPL03_RS05525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FPL03_RS05545	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FPL03_RS05555	COG0154	amidase activity
FPL03_RS05565	COG1217	gtp-binding protein TYPA
FPL03_RS05570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FPL03_RS05575	COG0039	L-malate dehydrogenase activity
FPL03_RS05580	COG0625	glutathione transferase activity
FPL03_RS05600	COG1902	pentaerythritol trinitrate reductase activity
FPL03_RS05600	COG0446	pyridine nucleotide-disulphide oxidoreductase
FPL03_RS05605	COG0604	alcohol dehydrogenase
FPL03_RS05635	COG0156	8-amino-7-oxononanoate synthase activity
FPL03_RS05640	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FPL03_RS05645	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FPL03_RS05650	COG4208	sulfate ABC transporter
FPL03_RS05655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FPL03_RS05665	COG1063	alcohol dehydrogenase
FPL03_RS05695	COG0406	alpha-ribazole phosphatase activity
FPL03_RS05700	COG0285	dihydrofolate synthase activity
FPL03_RS05720	COG2833	Protein of unknown function (DUF455)
FPL03_RS05740	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL03_RS05745	COG0671	phosphoesterase, PA-phosphatase related
FPL03_RS05750	COG0438	transferase activity, transferring glycosyl groups
FPL03_RS05760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FPL03_RS05775	COG4783	chaperone-mediated protein folding
FPL03_RS05790	COG0473	3-isopropylmalate dehydrogenase activity
FPL03_RS06050	COG4695	Portal protein
FPL03_RS06110	COG0544	peptidyl-prolyl cis-trans isomerase activity
FPL03_RS06120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FPL03_RS06150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL03_RS06160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL03_RS06170	COG0328	RNA-DNA hybrid ribonuclease activity
FPL03_RS06175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FPL03_RS06180	COG0631	protein serine/threonine phosphatase activity
FPL03_RS06195	COG0859	PFAM glycosyl transferase family 9
FPL03_RS06200	COG3642	lipopolysaccharide core region biosynthetic process
FPL03_RS06205	COG1234	tRNA 3'-trailer cleavage
FPL03_RS06210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FPL03_RS06220	COG0315	cyclic pyranopterin monophosphate synthase activity
FPL03_RS06225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FPL03_RS06230	COG0314	molybdopterin synthase activity
FPL03_RS06250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FPL03_RS06255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FPL03_RS06260	COG0537	adenosine 5'-monophosphoramidase activity
FPL03_RS06280	COG0714	Associated with various cellular activities
FPL03_RS06300	COG0424	maF-like protein
FPL03_RS06305	COG1399	metal-binding, possibly nucleic acid-binding protein
FPL03_RS06310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FPL03_RS06315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL03_RS06330	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS06345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FPL03_RS06350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FPL03_RS06395	COG3829	transcription factor binding
FPL03_RS06415	COG3609	addiction module antidote protein, CC2985 family
FPL03_RS06450	COG2373	Large extracellular alpha-helical protein
FPL03_RS06470	COG4953	penicillin-binding protein 1C
FPL03_RS06480	COG0678	peroxiredoxin activity
FPL03_RS06500	COG0330	HflC and HflK could
FPL03_RS06505	COG0330	HflC and HflK could
FPL03_RS06515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FPL03_RS06520	COG0308	aminopeptidase N
FPL03_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS06530	COG1309	transcriptional regulator
FPL03_RS06560	COG0732	type I restriction modification DNA specificity domain
FPL03_RS06595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FPL03_RS06605	COG3387	PFAM Glycoside hydrolase 15-related
FPL03_RS06610	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS06620	COG3537	Alpha-1,2-mannosidase
FPL03_RS06625	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS06645	COG0492	ferredoxin-NADP+ reductase activity
FPL03_RS06670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FPL03_RS06675	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FPL03_RS06680	COG2080	2 iron, 2 sulfur cluster binding
FPL03_RS06715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL03_RS06730	COG0587	DNA-directed DNA polymerase activity
FPL03_RS06750	COG1297	OPT oligopeptide transporter protein
FPL03_RS06765	COG0823	Involved in the tonB-independent uptake of proteins
FPL03_RS06765	COG1506	peptidase
FPL03_RS06785	COG2207	Transcriptional regulator
FPL03_RS06785	COG1917	Cupin 2, conserved barrel domain protein
FPL03_RS06805	COG0753	catalase activity
FPL03_RS06810	COG0656	L-ascorbic acid biosynthetic process
FPL03_RS06820	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FPL03_RS06820	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FPL03_RS06825	COG2814	Major facilitator Superfamily
FPL03_RS06840	COG2194	sulfuric ester hydrolase activity
FPL03_RS06855	COG0745	RESPONSE REGULATOR receiver
FPL03_RS06860	COG0642	Histidine kinase
FPL03_RS06870	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FPL03_RS06875	COG2894	cell division
FPL03_RS06880	COG0850	regulation of cytokinetic process
FPL03_RS06895	COG4585	Histidine kinase
FPL03_RS06900	COG2197	response regulator
FPL03_RS06915	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FPL03_RS06950	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FPL03_RS06960	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FPL03_RS06980	COG1946	Acyl-CoA thioesterase
FPL03_RS06995	COG0824	Thioesterase
FPL03_RS07000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FPL03_RS07005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FPL03_RS07010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FPL03_RS07015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FPL03_RS07020	COG0268	Binds directly to 16S ribosomal RNA
FPL03_RS07030	COG0196	riboflavin kinase activity
FPL03_RS07035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FPL03_RS07040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FPL03_RS07045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FPL03_RS07060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FPL03_RS07065	COG1845	cytochrome c oxidase, subunit III
FPL03_RS07070	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FPL03_RS07085	COG3152	Membrane
FPL03_RS07095	COG2207	Transcriptional regulator
FPL03_RS07100	COG0326	Molecular chaperone. Has ATPase activity
FPL03_RS07115	COG1366	Belongs to the anti-sigma-factor antagonist family
FPL03_RS07120	COG1366	Belongs to the anti-sigma-factor antagonist family
FPL03_RS07125	COG2172	sigma factor antagonist activity
FPL03_RS07150	COG4771	TonB-dependent receptor
FPL03_RS07160	COG5507	3-demethylubiquinone-9 3-methyltransferase
FPL03_RS07165	COG2205	protein histidine kinase activity
FPL03_RS07175	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FPL03_RS07180	COG4999	Histidine kinase
FPL03_RS07180	COG3437	response regulator, receiver
FPL03_RS07180	COG2205	protein histidine kinase activity
FPL03_RS07180	COG3850	Histidine kinase
FPL03_RS07185	COG4191	Histidine kinase
FPL03_RS07185	COG0784	Response regulator, receiver
FPL03_RS07210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FPL03_RS07220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FPL03_RS07230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FPL03_RS07235	COG0228	four-way junction DNA binding
FPL03_RS07240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FPL03_RS07245	COG0336	Belongs to the RNA methyltransferase TrmD family
FPL03_RS07250	COG0335	large ribosomal subunit rRNA binding
FPL03_RS07255	COG0534	Mate efflux family protein
FPL03_RS07275	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FPL03_RS07285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FPL03_RS07310	COG2963	transposase activity
FPL03_RS07325	COG3250	beta-galactosidase activity
FPL03_RS07330	COG3867	Arabinogalactan endo-beta-1,4-galactanase
FPL03_RS07350	COG1960	acyl-CoA dehydrogenase activity
FPL03_RS07355	COG1024	Enoyl-CoA hydratase
FPL03_RS07390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FPL03_RS07395	COG0481	GTPase activity
FPL03_RS07410	COG0571	ribonuclease III activity
FPL03_RS07415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FPL03_RS07420	COG1381	Involved in DNA repair and RecF pathway recombination
FPL03_RS07430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FPL03_RS07435	COG2954	triphosphatase activity
FPL03_RS07440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FPL03_RS07445	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FPL03_RS07450	COG3046	protein related to deoxyribodipyrimidine photolyase
FPL03_RS07455	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL03_RS07460	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FPL03_RS07465	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FPL03_RS07470	COG1278	Cold shock
FPL03_RS07490	COG1201	RNA secondary structure unwinding
FPL03_RS07495	COG1793	dna ligase
FPL03_RS07505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FPL03_RS07505	COG1793	dna ligase
FPL03_RS07535	COG0183	Belongs to the thiolase family
FPL03_RS07560	COG1451	nucleotide metabolic process
FPL03_RS07565	COG5487	UPF0391 membrane protein
FPL03_RS07575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FPL03_RS07590	COG1077	Cell shape determining protein MreB Mrl
FPL03_RS07595	COG1047	Peptidyl-prolyl cis-trans
FPL03_RS07605	COG2824	Alkylphosphonate utilization operon protein PhnA
FPL03_RS07615	COG1902	pentaerythritol trinitrate reductase activity
FPL03_RS07620	COG2814	Major facilitator Superfamily
FPL03_RS07655	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FPL03_RS07655	COG0392	lysyltransferase activity
FPL03_RS07665	COG0251	oxidation-reduction process
FPL03_RS07670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FPL03_RS07685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FPL03_RS07710	COG1595	DNA-templated transcription, initiation
FPL03_RS07730	COG2878	Part of a membrane complex involved in electron transport
FPL03_RS07740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL03_RS07740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL03_RS07755	COG1131	(ABC) transporter
FPL03_RS07760	COG0346	lactoylglutathione lyase activity
FPL03_RS07765	COG0833	amino acid
FPL03_RS07770	COG2040	homocysteine
FPL03_RS07780	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FPL03_RS07800	COG1695	Transcriptional regulator
FPL03_RS07820	COG1981	membrane
FPL03_RS07835	COG0825	malonyl-CoA metabolic process
FPL03_RS07845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FPL03_RS07850	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL03_RS07855	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL03_RS07860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPL03_RS07865	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL03_RS07880	COG0750	zinc metalloprotease
FPL03_RS07885	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FPL03_RS07890	COG0575	Belongs to the CDS family
FPL03_RS07895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FPL03_RS07900	COG0233	cytoplasmic translational termination
FPL03_RS07905	COG0528	UMP kinase activity
FPL03_RS07915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FPL03_RS07920	COG0052	Belongs to the universal ribosomal protein uS2 family
FPL03_RS07960	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FPL03_RS07970	COG1393	Belongs to the ArsC family
FPL03_RS07975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FPL03_RS07980	COG0367	asparagine synthase
FPL03_RS07990	COG4774	siderophore transport
FPL03_RS08005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FPL03_RS08040	COG1566	PFAM secretion protein HlyD family protein
FPL03_RS08045	COG2814	Major facilitator Superfamily
FPL03_RS08095	COG0339	signal peptide processing
FPL03_RS08105	COG0386	Belongs to the glutathione peroxidase family
FPL03_RS08160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FPL03_RS08165	COG0084	hydrolase, TatD family'
FPL03_RS08180	COG1960	acyl-CoA dehydrogenase activity
FPL03_RS08200	COG0367	asparagine synthase
FPL03_RS08210	COG0305	Participates in initiation and elongation during chromosome replication
FPL03_RS08215	COG0415	Belongs to the DNA photolyase family
FPL03_RS08235	COG0583	DNA-binding transcription factor activity
FPL03_RS08280	COG3706	GGDEF domain
FPL03_RS08315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FPL03_RS08330	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL03_RS08340	COG0497	DNA recombination
FPL03_RS08345	COG1420	regulation of RNA biosynthetic process
FPL03_RS08350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FPL03_RS08355	COG0443	Heat shock 70 kDa protein
FPL03_RS08360	COG0484	heat shock protein binding
FPL03_RS08400	COG0583	DNA-binding transcription factor activity
FPL03_RS08405	COG1132	(ABC) transporter
FPL03_RS08440	COG2850	peptidyl-arginine hydroxylation
FPL03_RS08460	COG1253	flavin adenine dinucleotide binding
FPL03_RS08490	COG1131	(ABC) transporter
FPL03_RS08495	COG1725	Transcriptional regulator
FPL03_RS08505	COG0386	Belongs to the glutathione peroxidase family
FPL03_RS08520	COG2900	Belongs to the SlyX family
FPL03_RS08545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPL03_RS08555	COG0646	methionine synthase
FPL03_RS08555	COG1410	methionine synthase
FPL03_RS08560	COG1410	methionine synthase
FPL03_RS08560	COG0646	methionine synthase
FPL03_RS08565	COG2226	methyltransferase
FPL03_RS08570	COG1960	acyl-CoA dehydrogenase activity
FPL03_RS08575	COG1960	acyl-CoA dehydrogenase activity
FPL03_RS08580	COG1960	acyl-CoA dehydrogenase activity
FPL03_RS08585	COG1960	acyl-CoA dehydrogenase activity
FPL03_RS08590	COG1960	acyl-CoA dehydrogenase activity
FPL03_RS08610	COG0557	exoribonuclease II activity
FPL03_RS08620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPL03_RS08630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FPL03_RS08640	COG0704	Plays a role in the regulation of phosphate uptake
FPL03_RS08645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FPL03_RS08650	COG0581	inorganic phosphate transmembrane transporter activity
FPL03_RS08655	COG0573	inorganic phosphate transmembrane transporter activity
FPL03_RS08660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FPL03_RS08685	COG0659	secondary active sulfate transmembrane transporter activity
FPL03_RS08690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FPL03_RS08700	COG1024	Enoyl-CoA hydratase
FPL03_RS08710	COG0494	nUDIX hydrolase
FPL03_RS08745	COG0488	(ABC) transporter
FPL03_RS08755	COG0116	Belongs to the methyltransferase superfamily
FPL03_RS08755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FPL03_RS08760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FPL03_RS08785	COG2925	Exonuclease
FPL03_RS08795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL03_RS08800	COG3844	kynureninase activity
FPL03_RS08810	COG0662	Cupin 2, conserved barrel domain protein
FPL03_RS08815	COG0288	reversible hydration of carbon dioxide
FPL03_RS08880	COG2808	Putative FMN-binding domain
FPL03_RS08900	COG0017	Asparaginyl-tRNA synthetase
FPL03_RS08910	COG0316	Belongs to the HesB IscA family
FPL03_RS08915	COG0360	Binds together with S18 to 16S ribosomal RNA
FPL03_RS08920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FPL03_RS08925	COG0359	binds to the 23S rRNA
FPL03_RS08935	COG3115	cell septum assembly
FPL03_RS08945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL03_RS08950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FPL03_RS08955	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FPL03_RS08970	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FPL03_RS08980	COG4993	Dehydrogenase
FPL03_RS08995	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FPL03_RS09005	COG2986	histidine ammonia-lyase
FPL03_RS09010	COG1228	amidohydrolase
FPL03_RS09055	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FPL03_RS09060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FPL03_RS09065	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FPL03_RS09070	COG1605	Chorismate mutase
FPL03_RS09070	COG0077	Prephenate dehydratase
FPL03_RS09075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FPL03_RS09090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FPL03_RS09095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FPL03_RS09100	COG0583	DNA-binding transcription factor activity
FPL03_RS09115	COG0840	transmembrane signaling receptor activity
FPL03_RS09150	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FPL03_RS09155	COG4191	Histidine kinase
FPL03_RS09155	COG0784	Response regulator, receiver
FPL03_RS09170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL03_RS09180	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FPL03_RS09190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FPL03_RS09205	COG1595	DNA-templated transcription, initiation
FPL03_RS09260	COG2244	polysaccharide biosynthetic process
FPL03_RS09290	COG2264	protein methyltransferase activity
FPL03_RS09315	COG1136	(ABC) transporter
FPL03_RS09325	COG0477	Major facilitator Superfamily
FPL03_RS09330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL03_RS09345	COG1253	flavin adenine dinucleotide binding
FPL03_RS09360	COG0306	phosphate transporter
FPL03_RS09385	COG0504	CTP synthase activity
FPL03_RS09390	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FPL03_RS09400	COG0148	phosphopyruvate hydratase activity
FPL03_RS09405	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FPL03_RS09410	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FPL03_RS09415	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FPL03_RS09420	COG0585	pseudouridine synthase activity
FPL03_RS09425	COG2840	Smr protein MutS2
FPL03_RS09430	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FPL03_RS09435	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FPL03_RS09440	COG1238	metal cluster binding
FPL03_RS09460	COG1534	Rna-binding protein
FPL03_RS09465	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FPL03_RS09475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FPL03_RS09480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FPL03_RS09490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FPL03_RS09495	COG1546	Belongs to the CinA family
FPL03_RS09505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL03_RS09510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FPL03_RS09520	COG2137	regulation of response to DNA damage stimulus
FPL03_RS09525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FPL03_RS09530	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FPL03_RS09690	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
FPL03_RS09745	COG3179	chitinase
FPL03_RS09825	COG1196	nuclear chromosome segregation
FPL03_RS09890	COG0582	viral genome integration into host DNA
FPL03_RS09905	COG1741	Belongs to the pirin family
FPL03_RS09910	COG0583	DNA-binding transcription factor activity
FPL03_RS09935	COG0351	phosphomethylpyrimidine kinase
FPL03_RS09950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FPL03_RS09955	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FPL03_RS09970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPL03_RS09980	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FPL03_RS09985	COG3734	2-keto-3-deoxy-galactonokinase
FPL03_RS09995	COG4948	Mandelate Racemase Muconate Lactonizing
FPL03_RS10000	COG0800	Aldolase
FPL03_RS10040	COG1501	Belongs to the glycosyl hydrolase 31 family
FPL03_RS10050	COG1070	Carbohydrate kinase
FPL03_RS10055	COG2115	Belongs to the xylose isomerase family
FPL03_RS10060	COG0477	Major facilitator Superfamily
FPL03_RS10080	COG0860	N-Acetylmuramoyl-L-alanine amidase
FPL03_RS10085	COG1469	GTP cyclohydrolase I activity
FPL03_RS10105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FPL03_RS10110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FPL03_RS10115	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FPL03_RS10120	COG0166	Belongs to the GPI family
FPL03_RS10145	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL03_RS10160	COG2203	Gaf domain
FPL03_RS10160	COG4251	negative regulation of phosphorylation
FPL03_RS10160	COG3706	GGDEF domain
FPL03_RS10160	COG5001	Diguanylate cyclase
FPL03_RS10165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL03_RS10170	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FPL03_RS10180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FPL03_RS10185	COG0671	phosphoesterase, PA-phosphatase related
FPL03_RS10200	COG1794	racemase activity, acting on amino acids and derivatives
FPL03_RS10210	COG0697	spore germination
FPL03_RS10215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FPL03_RS10220	COG0167	dihydroorotate dehydrogenase activity
FPL03_RS10240	COG1012	belongs to the aldehyde dehydrogenase family
FPL03_RS10300	COG2003	Belongs to the UPF0758 family
FPL03_RS10375	COG0758	DNA mediated transformation
FPL03_RS10565	COG1215	transferase activity, transferring glycosyl groups
FPL03_RS10570	COG0726	polysaccharide deacetylase
FPL03_RS10570	COG1649	PFAM Uncharacterised BCR, COG1649
FPL03_RS10655	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FPL03_RS10690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL03_RS10695	COG0124	histidyl-tRNA synthetase
FPL03_RS10705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FPL03_RS10710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FPL03_RS10715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL03_RS10720	COG0131	Imidazoleglycerol-phosphate dehydratase
FPL03_RS10720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FPL03_RS10725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FPL03_RS10730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FPL03_RS10735	COG0107	imidazoleglycerol-phosphate synthase activity
FPL03_RS10740	COG0140	phosphoribosyl-ATP diphosphatase activity
FPL03_RS10740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FPL03_RS10755	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FPL03_RS10760	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FPL03_RS10765	COG0235	Class ii aldolase
FPL03_RS10770	COG0531	amino acid
FPL03_RS10775	COG0531	amino acid
FPL03_RS10785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FPL03_RS10790	COG0277	FAD linked oxidase domain protein
FPL03_RS10810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FPL03_RS10855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL03_RS10860	COG2258	MOSC domain
FPL03_RS10865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FPL03_RS10870	COG0505	Belongs to the CarA family
FPL03_RS10880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FPL03_RS10885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL03_RS10895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FPL03_RS10905	COG3279	Response regulator of the LytR AlgR family
FPL03_RS10915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FPL03_RS10925	COG2198	Histidine kinase
FPL03_RS10925	COG2205	protein histidine kinase activity
FPL03_RS10925	COG0784	Response regulator, receiver
FPL03_RS10930	COG0784	Response regulator, receiver
FPL03_RS10930	COG2205	protein histidine kinase activity
FPL03_RS10930	COG2198	Histidine kinase
FPL03_RS10935	COG1024	Enoyl-CoA hydratase
FPL03_RS10940	COG0318	PFAM AMP-dependent synthetase and ligase
FPL03_RS10970	COG2267	carboxylic ester hydrolase activity
FPL03_RS10980	COG2201	protein-glutamate methylesterase activity
FPL03_RS10985	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FPL03_RS10995	COG0840	transmembrane signaling receptor activity
FPL03_RS11005	COG0835	chemotaxis
FPL03_RS11020	COG0840	transmembrane signaling receptor activity
FPL03_RS11025	COG0840	transmembrane signaling receptor activity
FPL03_RS11030	COG0840	transmembrane signaling receptor activity
FPL03_RS11040	COG0840	transmembrane signaling receptor activity
FPL03_RS11050	COG0840	transmembrane signaling receptor activity
FPL03_RS11055	COG0840	transmembrane signaling receptor activity
FPL03_RS11060	COG0840	transmembrane signaling receptor activity
FPL03_RS11065	COG0840	transmembrane signaling receptor activity
FPL03_RS11080	COG0840	transmembrane signaling receptor activity
FPL03_RS11100	COG2198	Histidine kinase
FPL03_RS11100	COG0643	Histidine kinase
FPL03_RS11105	COG0745	RESPONSE REGULATOR receiver
FPL03_RS11115	COG0835	chemotaxis
FPL03_RS11125	COG1360	Flagellar Motor Protein
FPL03_RS11130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FPL03_RS11230	COG0641	radical SAM
FPL03_RS11245	COG0784	Response regulator, receiver
FPL03_RS11245	COG0643	Histidine kinase
FPL03_RS11245	COG2198	Histidine kinase
FPL03_RS11275	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FPL03_RS11305	COG1684	flagellar biosynthetic protein fliR
FPL03_RS11320	COG3190	flagellar
FPL03_RS11370	COG1677	Flagellar hook-basal body complex protein FliE
FPL03_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS11410	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS11415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL03_RS11435	COG2201	protein-glutamate methylesterase activity
FPL03_RS11465	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FPL03_RS11470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FPL03_RS11475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FPL03_RS11485	COG1705	Flagellar rod assembly protein muramidase FlgJ
FPL03_RS11485	COG3951	Flagellar rod assembly protein muramidase FlgJ
FPL03_RS11490	COG1706	bacterial-type flagellum-dependent cell motility
FPL03_RS11495	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FPL03_RS11510	COG4787	bacterial-type flagellum-dependent cell motility
FPL03_RS11520	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FPL03_RS11525	COG1558	bacterial-type flagellum-dependent cell motility
FPL03_RS11535	COG0835	chemotaxis
FPL03_RS11535	COG0784	Response regulator, receiver
FPL03_RS11555	COG5002	protein histidine kinase activity
FPL03_RS11585	COG2915	High frequency lysogenization protein hflD homolog
FPL03_RS11590	COG0482	sulfurtransferase activity
FPL03_RS11605	COG0542	response to heat
FPL03_RS11615	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FPL03_RS11625	COG0492	ferredoxin-NADP+ reductase activity
FPL03_RS11630	COG1674	ftsk spoiiie
FPL03_RS11640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FPL03_RS11650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FPL03_RS11655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FPL03_RS11665	COG0183	Belongs to the thiolase family
FPL03_RS11670	COG1250	3-hydroxyacyl-CoA dehydrogenase
FPL03_RS11670	COG1024	Enoyl-CoA hydratase
FPL03_RS11685	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FPL03_RS11695	COG1426	Protein conserved in bacteria
FPL03_RS11705	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL03_RS11710	COG1160	GTP binding
FPL03_RS11715	COG0303	'Molybdopterin
FPL03_RS11720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FPL03_RS11760	COG0708	Exodeoxyribonuclease III
FPL03_RS11770	COG0303	'Molybdopterin
FPL03_RS11775	COG0746	molybdenum cofactor guanylyltransferase activity
FPL03_RS11785	COG1648	precorrin-2 dehydrogenase activity
FPL03_RS11785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FPL03_RS11815	COG3685	Protein conserved in bacteria
FPL03_RS11835	COG5001	Diguanylate cyclase
FPL03_RS11845	COG4566	intracellular signal transduction
FPL03_RS11885	COG3275	phosphorelay sensor kinase activity
FPL03_RS11890	COG3279	Response regulator of the LytR AlgR family
FPL03_RS11925	COG1238	metal cluster binding
FPL03_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS11965	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FPL03_RS11970	COG1073	alpha beta
FPL03_RS11970	COG2226	methyltransferase
FPL03_RS12020	COG0316	Belongs to the HesB IscA family
FPL03_RS12020	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FPL03_RS12025	COG2154	pterin-4-alpha-carbinolamine dehydratase
FPL03_RS12035	COG0428	transporter
FPL03_RS12040	COG3064	Membrane
FPL03_RS12050	COG1530	ribonuclease E activity
FPL03_RS12060	COG1054	Belongs to the UPF0176 family
FPL03_RS12080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FPL03_RS12120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FPL03_RS12125	COG0322	excinuclease ABC activity
FPL03_RS12135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FPL03_RS12140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FPL03_RS12145	COG1663	tetraacyldisaccharide 4'-kinase activity
FPL03_RS12150	COG1132	(ABC) transporter
FPL03_RS12160	COG0811	peptide transport
FPL03_RS12175	COG1136	(ABC) transporter
FPL03_RS12180	COG4591	ABC-type transport system involved in lipoprotein release permease component
FPL03_RS12190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FPL03_RS12195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FPL03_RS12210	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FPL03_RS12235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FPL03_RS12240	COG0837	glucose binding
FPL03_RS12245	COG0363	glucosamine-6-phosphate deaminase activity
FPL03_RS12250	COG0129	dihydroxy-acid dehydratase activity
FPL03_RS12255	COG0800	Aldolase
FPL03_RS12330	COG0784	Response regulator, receiver
FPL03_RS12330	COG2205	protein histidine kinase activity
FPL03_RS12335	COG2183	response to ionizing radiation
FPL03_RS12345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL03_RS12345	COG0723	plastoquinol--plastocyanin reductase activity
FPL03_RS12360	COG3243	poly(R)-hydroxyalkanoic acid synthase
FPL03_RS12370	COG1183	phosphatidylcholine synthase activity
FPL03_RS12375	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS12390	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FPL03_RS12400	COG0668	transmembrane transport
FPL03_RS12405	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FPL03_RS12420	COG1914	H( )-stimulated, divalent metal cation uptake system
FPL03_RS12440	COG2814	Major facilitator Superfamily
FPL03_RS12455	COG2197	response regulator
FPL03_RS12475	COG0583	DNA-binding transcription factor activity
FPL03_RS12480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FPL03_RS12485	COG3002	Belongs to the UPF0753 family
FPL03_RS12490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FPL03_RS12490	COG0519	Catalyzes the synthesis of GMP from XMP
FPL03_RS12500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FPL03_RS12510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPL03_RS12510	COG0475	glutathione-regulated potassium exporter activity
FPL03_RS12520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FPL03_RS12530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FPL03_RS12535	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FPL03_RS12545	COG0776	regulation of translation
FPL03_RS12550	COG0539	negative regulation of cytoplasmic translation
FPL03_RS12555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FPL03_RS12575	COG2957	Belongs to the agmatine deiminase family
FPL03_RS12580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPL03_RS12605	COG0395	ABC-type sugar transport system, permease component
FPL03_RS12610	COG1175	transmembrane transport
FPL03_RS12640	COG2350	Protein conserved in bacteria
FPL03_RS12645	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FPL03_RS12650	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FPL03_RS12655	COG1187	pseudouridine synthase activity
FPL03_RS12675	COG0436	Aminotransferase
FPL03_RS12680	COG4133	protoheme IX ABC transporter activity
FPL03_RS12700	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FPL03_RS12705	COG1138	Cytochrome C-type biogenesis protein
FPL03_RS12725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL03_RS12730	COG1278	Cold shock
FPL03_RS12735	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FPL03_RS12740	COG4988	ABC transporter
FPL03_RS12750	COG1294	oxidase, subunit
FPL03_RS12780	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FPL03_RS12785	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FPL03_RS12795	COG0165	Argininosuccinate lyase
FPL03_RS12800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FPL03_RS12810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FPL03_RS12815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FPL03_RS12825	COG0137	argininosuccinate synthase activity
FPL03_RS12830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FPL03_RS12840	COG0215	cysteine-tRNA ligase activity
FPL03_RS12845	COG2166	iron-sulfur cluster assembly
FPL03_RS12860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FPL03_RS12865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FPL03_RS12895	COG4302	ethanolamine ammonia-lyase activity
FPL03_RS12960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FPL03_RS12965	COG0402	S-adenosylhomocysteine deaminase activity
FPL03_RS12975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FPL03_RS12980	COG1509	lysine 2,3-aminomutase activity
FPL03_RS12985	COG5001	Diguanylate cyclase
FPL03_RS12985	COG3300	MHYT domain
FPL03_RS13000	COG0483	inositol monophosphate 1-phosphatase activity
FPL03_RS13005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FPL03_RS13025	COG0488	(ABC) transporter
FPL03_RS13030	COG0513	Belongs to the DEAD box helicase family
FPL03_RS13035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FPL03_RS13040	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FPL03_RS13050	COG0625	glutathione transferase activity
FPL03_RS13060	COG4681	YaeQ
FPL03_RS13065	COG2081	HI0933 family
FPL03_RS13075	COG0501	Belongs to the peptidase M48B family
FPL03_RS13080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL03_RS13085	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS13110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FPL03_RS13115	COG0860	N-Acetylmuramoyl-L-alanine amidase
FPL03_RS13120	COG0802	atpase or kinase
FPL03_RS13125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FPL03_RS13125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FPL03_RS13130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FPL03_RS13135	COG1570	exodeoxyribonuclease VII activity
FPL03_RS13145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FPL03_RS13190	COG0835	chemotaxis
FPL03_RS13195	COG0840	transmembrane signaling receptor activity
FPL03_RS13200	COG2094	Belongs to the DNA glycosylase MPG family
FPL03_RS13205	COG1201	RNA secondary structure unwinding
FPL03_RS13225	COG2969	positive regulation of protein catabolic process
FPL03_RS13230	COG0625	glutathione transferase activity
FPL03_RS13235	COG2857	Cytochrome c1
FPL03_RS13240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FPL03_RS13245	COG0723	plastoquinol--plastocyanin reductase activity
FPL03_RS13255	COG0741	lytic transglycosylase activity
FPL03_RS13270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FPL03_RS13280	COG1702	phosphate starvation-inducible protein PhoH
FPL03_RS13290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FPL03_RS13300	COG4535	Mg2 and Co2 transporter CorC
FPL03_RS13315	COG1012	belongs to the aldehyde dehydrogenase family
FPL03_RS13320	COG1177	transmembrane transport
FPL03_RS13325	COG1176	ABC-type spermidine putrescine transport system, permease component I
FPL03_RS13350	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FPL03_RS13370	COG0174	glutamine synthetase
FPL03_RS13375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL03_RS13385	COG2703	oxygen carrier activity
FPL03_RS13390	COG0477	Major facilitator Superfamily
FPL03_RS13405	COG0243	molybdopterin cofactor binding
FPL03_RS13410	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FPL03_RS13415	COG2223	nitrite transmembrane transporter activity
FPL03_RS13430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FPL03_RS13440	COG2733	membrane
FPL03_RS13445	COG5002	protein histidine kinase activity
FPL03_RS13445	COG2205	protein histidine kinase activity
FPL03_RS13445	COG0784	Response regulator, receiver
FPL03_RS13455	COG0477	Major facilitator Superfamily
FPL03_RS13470	COG2902	Dehydrogenase
FPL03_RS13480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL03_RS13485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL03_RS13495	COG1609	Transcriptional regulator
FPL03_RS13500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FPL03_RS13500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL03_RS13505	COG1105	Belongs to the carbohydrate kinase PfkB family
FPL03_RS13510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FPL03_RS13510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FPL03_RS13530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FPL03_RS13540	COG1862	Preprotein translocase
FPL03_RS13545	COG0343	queuine tRNA-ribosyltransferase activity
FPL03_RS13550	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FPL03_RS13590	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FPL03_RS13595	COG3291	Pkd domain containing protein
FPL03_RS13600	COG0405	Gamma-glutamyltransferase
FPL03_RS13605	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FPL03_RS13620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FPL03_RS13625	COG0742	ribosomal rna small subunit methyltransferase
FPL03_RS13630	COG0326	Molecular chaperone. Has ATPase activity
FPL03_RS13760	COG0531	amino acid
FPL03_RS13775	COG0006	proline dipeptidase activity
FPL03_RS13785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPL03_RS13800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL03_RS13805	COG3938	Belongs to the proline racemase family
FPL03_RS13815	COG0552	protein localization to endoplasmic reticulum
FPL03_RS13825	COG1194	a g-specific adenine glycosylase
FPL03_RS13830	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FPL03_RS13835	COG0784	Response regulator, receiver
FPL03_RS13835	COG4191	Histidine kinase
FPL03_RS13850	COG0322	excinuclease ABC activity
FPL03_RS13865	COG3040	lipid binding
FPL03_RS13880	COG1960	acyl-CoA dehydrogenase activity
FPL03_RS13890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FPL03_RS13910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL03_RS13915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL03_RS13920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL03_RS13945	COG0438	transferase activity, transferring glycosyl groups
FPL03_RS13955	COG0438	transferase activity, transferring glycosyl groups
FPL03_RS13960	COG0438	transferase activity, transferring glycosyl groups
FPL03_RS14010	COG0072	phenylalanine-tRNA ligase activity
FPL03_RS14010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL03_RS14015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FPL03_RS14030	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FPL03_RS14035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FPL03_RS14050	COG2211	Major facilitator Superfamily
FPL03_RS14060	COG1082	Xylose isomerase domain protein TIM barrel
FPL03_RS14075	COG0366	Alpha amylase catalytic
FPL03_RS14195	COG3702	type iv secretory pathway
FPL03_RS14215	COG2948	multi-organism process
FPL03_RS14235	COG3505	Type IV secretory pathway VirD4
FPL03_RS14250	COG0556	nucleotide-excision repair
FPL03_RS14295	COG1611	Belongs to the LOG family
FPL03_RS14310	COG2095	MarC family integral membrane protein
FPL03_RS14320	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FPL03_RS14355	COG1185	polyribonucleotide nucleotidyltransferase activity
FPL03_RS14360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FPL03_RS14365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FPL03_RS14370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FPL03_RS14375	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FPL03_RS14380	COG0195	Participates in both transcription termination and antitermination
FPL03_RS14385	COG0779	Required for maturation of 30S ribosomal subunits
FPL03_RS14395	COG1007	ATP synthesis coupled electron transport
FPL03_RS14420	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL03_RS14425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FPL03_RS14435	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FPL03_RS14440	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FPL03_RS14445	COG0649	NAD binding
FPL03_RS14450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL03_RS14455	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL03_RS14460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL03_RS14475	COG0149	triose-phosphate isomerase activity
FPL03_RS14480	COG0300	oxidoreductase activity
FPL03_RS14510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FPL03_RS14515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FPL03_RS14520	COG0159	tryptophan synthase activity
FPL03_RS14530	COG0133	tryptophan synthase activity
FPL03_RS14540	COG0135	phosphoribosylanthranilate isomerase activity
FPL03_RS14545	COG0101	tRNA pseudouridine synthase activity
FPL03_RS14565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FPL03_RS14570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FPL03_RS14575	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FPL03_RS14580	COG2890	protein-(glutamine-N5) methyltransferase activity
FPL03_RS14590	COG0688	phosphatidylethanolamine metabolic process
FPL03_RS14605	COG0433	COG0433 Predicted ATPase
FPL03_RS14610	COG0494	nUDIX hydrolase
FPL03_RS14630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL03_RS14635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FPL03_RS14645	COG2336	PFAM SpoVT AbrB
FPL03_RS14695	COG0420	3'-5' exonuclease activity
FPL03_RS14735	COG0717	Belongs to the dCTP deaminase family
FPL03_RS14745	COG0489	protein tyrosine kinase activity
FPL03_RS14765	COG3590	peptidase
FPL03_RS14775	COG3590	peptidase
FPL03_RS14795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL03_RS14800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL03_RS14805	COG2311	Membrane
FPL03_RS14810	COG1047	Peptidyl-prolyl cis-trans
FPL03_RS14815	COG0791	NLP P60 protein
FPL03_RS14820	COG0791	NLP P60 protein
FPL03_RS14830	COG4106	trans-aconitate 2-methyltransferase activity
FPL03_RS14835	COG1301	dicarboxylic acid transport
FPL03_RS14840	COG1785	Belongs to the alkaline phosphatase family
FPL03_RS14850	COG0037	tRNA processing
FPL03_RS14855	COG1722	exodeoxyribonuclease VII activity
FPL03_RS14860	COG0142	geranyltranstransferase activity
FPL03_RS14865	COG4104	PAAR repeat-containing protein
FPL03_RS14875	COG0312	modulator of DNA gyrase
FPL03_RS14880	COG3028	Belongs to the UPF0307 family
FPL03_RS14885	COG0312	modulator of DNA gyrase
FPL03_RS14895	COG3164	Protein of unknown function
FPL03_RS14905	COG0424	maF-like protein
FPL03_RS14910	COG2968	Membrane
FPL03_RS14925	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FPL03_RS14940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FPL03_RS14955	COG0495	leucyl-tRNA aminoacylation
FPL03_RS14965	COG3118	belongs to the thioredoxin family
FPL03_RS14990	COG2155	Conserved Protein
FPL03_RS15035	COG1132	(ABC) transporter
FPL03_RS15065	COG1538	Outer membrane efflux protein
FPL03_RS15070	COG0745	RESPONSE REGULATOR receiver
FPL03_RS15075	COG5000	phosphorelay sensor kinase activity
FPL03_RS15075	COG5002	protein histidine kinase activity
FPL03_RS15080	COG0475	glutathione-regulated potassium exporter activity
FPL03_RS15090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FPL03_RS15115	COG1187	pseudouridine synthase activity
FPL03_RS15120	COG5002	protein histidine kinase activity
FPL03_RS15120	COG5001	Diguanylate cyclase
FPL03_RS15230	COG2951	lytic endotransglycosylase activity
FPL03_RS15235	COG4644	lycopene metabolic process
FPL03_RS15250	COG2369	cell adhesion
FPL03_RS15300	COG0667	Aldo Keto reductase
FPL03_RS15305	COG2814	Major facilitator Superfamily
FPL03_RS15310	COG0583	DNA-binding transcription factor activity
FPL03_RS15315	COG2207	Transcriptional regulator
FPL03_RS15330	COG0667	Aldo Keto reductase
FPL03_RS15335	COG1309	transcriptional regulator
FPL03_RS15345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL03_RS15360	COG0735	belongs to the Fur family
FPL03_RS15365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL03_RS15390	COG4452	Inner membrane protein CreD
FPL03_RS15405	COG2205	protein histidine kinase activity
FPL03_RS15410	COG0745	RESPONSE REGULATOR receiver
FPL03_RS15415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FPL03_RS15430	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FPL03_RS15440	COG0643	Histidine kinase
FPL03_RS15440	COG2198	Histidine kinase
FPL03_RS15445	COG0840	transmembrane signaling receptor activity
FPL03_RS15450	COG0835	chemotaxis
FPL03_RS15455	COG2202	Pas domain
FPL03_RS15455	COG2199	diguanylate cyclase activity
FPL03_RS15455	COG2200	EAL domain
FPL03_RS15460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FPL03_RS15465	COG2201	protein-glutamate methylesterase activity
FPL03_RS15470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL03_RS15475	COG3590	peptidase
FPL03_RS15485	COG0588	phosphoglycerate mutase activity
FPL03_RS15490	COG1515	deoxyribonuclease V activity
FPL03_RS15500	COG1741	Belongs to the pirin family
FPL03_RS15515	COG1741	Belongs to the pirin family
FPL03_RS15520	COG1966	Carbon starvation protein
FPL03_RS15525	COG2879	small protein
FPL03_RS15570	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FPL03_RS15575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FPL03_RS15580	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FPL03_RS15585	COG2080	2 iron, 2 sulfur cluster binding
FPL03_RS15595	COG2203	Gaf domain
FPL03_RS15595	COG4251	negative regulation of phosphorylation
FPL03_RS15595	COG3706	GGDEF domain
FPL03_RS15595	COG5001	Diguanylate cyclase
FPL03_RS15600	COG0629	single-stranded DNA binding
FPL03_RS15605	COG0142	geranyltranstransferase activity
FPL03_RS15615	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FPL03_RS15630	COG0527	aspartate kinase activity
FPL03_RS15635	COG0384	phenazine biosynthesis protein PhzF
FPL03_RS15640	COG0384	phenazine biosynthesis protein PhzF
FPL03_RS15650	COG1764	response to oxidative stress
FPL03_RS15655	COG0540	Belongs to the ATCase OTCase family
FPL03_RS15660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FPL03_RS15665	COG1678	Uncharacterized ACR, COG1678
FPL03_RS15675	COG0519	Catalyzes the synthesis of GMP from XMP
FPL03_RS15700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FPL03_RS15715	COG0739	heme binding
FPL03_RS15735	COG0693	protein deglycase activity
FPL03_RS15745	COG1959	2 iron, 2 sulfur cluster binding
FPL03_RS15750	COG0719	Fe-S assembly protein
FPL03_RS15755	COG0396	ATPase activity
FPL03_RS15760	COG0719	Fe-S assembly protein
FPL03_RS15765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FPL03_RS15775	COG2146	nitrite reductase [NAD(P)H] activity
FPL03_RS15780	COG4774	siderophore transport
FPL03_RS15785	COG3128	pkhd-type hydroxylase
FPL03_RS15810	COG1477	protein flavinylation
FPL03_RS15815	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FPL03_RS15830	COG1555	photosystem II stabilization
FPL03_RS15845	COG3178	'Phosphotransferase
FPL03_RS15850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FPL03_RS15860	COG0628	permease
FPL03_RS15870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FPL03_RS15880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FPL03_RS15900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FPL03_RS15905	COG0271	Belongs to the BolA IbaG family
FPL03_RS15915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FPL03_RS15925	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FPL03_RS15930	COG1137	ATPase activity
FPL03_RS15945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL03_RS15950	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FPL03_RS15955	COG1660	Displays ATPase and GTPase activities
FPL03_RS15965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL03_RS15970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FPL03_RS15980	COG2239	Acts as a magnesium transporter
FPL03_RS15995	COG1294	oxidase, subunit
FPL03_RS16000	COG1271	oxidase subunit
FPL03_RS16010	COG1113	amino acid transport
FPL03_RS16040	COG2197	response regulator
FPL03_RS16045	COG0531	amino acid
FPL03_RS16075	COG1234	tRNA 3'-trailer cleavage
FPL03_RS16150	COG0754	glutathionylspermidine amidase activity
FPL03_RS16175	COG1842	Phage shock protein A
FPL03_RS16185	COG0259	pyridoxamine-phosphate oxidase activity
FPL03_RS16190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FPL03_RS16195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FPL03_RS16205	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FPL03_RS16210	COG0477	Major facilitator Superfamily
FPL03_RS16230	COG0784	Response regulator, receiver
FPL03_RS16230	COG2205	protein histidine kinase activity
FPL03_RS16230	COG2198	Histidine kinase
FPL03_RS16235	COG2353	YceI-like domain
FPL03_RS16255	COG1760	l-serine dehydratase
FPL03_RS16270	COG0460	homoserine dehydrogenase
FPL03_RS16270	COG0527	aspartate kinase activity
FPL03_RS16275	COG0626	cystathionine gamma-synthase activity
FPL03_RS16280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL03_RS16285	COG0739	heme binding
FPL03_RS16290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FPL03_RS16295	COG1272	protein, Hemolysin III
FPL03_RS16300	COG2982	Protein involved in outer membrane biogenesis
FPL03_RS16305	COG0517	IMP dehydrogenase activity
FPL03_RS16305	COG0516	GMP reductase activity
FPL03_RS16310	COG0463	Glycosyl transferase, family 2
FPL03_RS16315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FPL03_RS16320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FPL03_RS16330	COG4771	TonB-dependent receptor
FPL03_RS16335	COG1309	transcriptional regulator
FPL03_RS16345	COG1960	acyl-CoA dehydrogenase activity
FPL03_RS16375	COG0509	glycine decarboxylation via glycine cleavage system
FPL03_RS16380	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FPL03_RS16405	COG1742	UPF0060 membrane protein
FPL03_RS16410	COG3956	TIGRFAM MazG family protein
FPL03_RS16420	COG0494	nUDIX hydrolase
FPL03_RS16430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FPL03_RS16435	COG0837	glucose binding
FPL03_RS16450	COG1388	LysM domain
FPL03_RS16450	COG3858	chitin binding
FPL03_RS16465	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL03_RS16480	COG0531	amino acid
FPL03_RS16490	COG1486	melibiose metabolic process
FPL03_RS16500	COG3537	Alpha-1,2-mannosidase
FPL03_RS16540	COG3142	Participates in the control of copper homeostasis
FPL03_RS16545	COG1446	asparaginase
FPL03_RS16575	COG0643	Histidine kinase
FPL03_RS16575	COG0784	Response regulator, receiver
FPL03_RS16575	COG2198	Histidine kinase
FPL03_RS16580	COG0840	transmembrane signaling receptor activity
FPL03_RS16585	COG0835	chemotaxis
FPL03_RS16600	COG0189	ligase activity
FPL03_RS16610	COG1397	ADP-ribosylglycohydrolase
FPL03_RS16620	COG1199	ATP-dependent helicase activity
FPL03_RS16630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FPL03_RS16635	COG1215	transferase activity, transferring glycosyl groups
FPL03_RS16650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPL03_RS16660	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FPL03_RS16665	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FPL03_RS16670	COG0535	radical SAM domain protein
FPL03_RS16675	COG0535	radical SAM domain protein
FPL03_RS16690	COG0837	glucose binding
FPL03_RS16705	COG1643	Atp-dependent helicase
FPL03_RS16710	COG0783	Belongs to the Dps family
FPL03_RS16715	COG0514	ATP-dependent DNA helicase (RecQ)
FPL03_RS16750	COG0840	transmembrane signaling receptor activity
FPL03_RS16770	COG3920	Histidine kinase
FPL03_RS16775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FPL03_RS17015	COG4695	Portal protein
FPL03_RS17055	COG0602	queuosine metabolic process
FPL03_RS17065	COG2885	chlorophyll binding
FPL03_RS17070	COG0823	Involved in the tonB-independent uptake of proteins
FPL03_RS17080	COG0848	biopolymer transport protein
FPL03_RS17090	COG0824	Thioesterase
FPL03_RS17095	COG2255	four-way junction helicase activity
FPL03_RS17105	COG3158	transport of potassium into the cell
FPL03_RS17110	COG0632	four-way junction helicase activity
FPL03_RS17115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FPL03_RS17120	COG0217	transcriptional regulatory protein
FPL03_RS17135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FPL03_RS17260	COG2951	lytic endotransglycosylase activity
FPL03_RS17275	COG0477	Major facilitator Superfamily
FPL03_RS17315	COG0488	(ABC) transporter
FPL03_RS17355	COG4651	solute:proton antiporter activity
FPL03_RS17355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPL03_RS17380	COG4772	TonB-dependent receptor
FPL03_RS17390	COG4264	IucA IucC family
FPL03_RS17405	COG0019	diaminopimelate decarboxylase activity
FPL03_RS17425	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FPL03_RS17435	COG1492	cobalamin metabolic process
FPL03_RS17445	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FPL03_RS17470	COG4206	TonB-dependent receptor
FPL03_RS17475	COG0542	response to heat
FPL03_RS17480	COG1116	anion transmembrane transporter activity
FPL03_RS17485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL03_RS17490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FPL03_RS17495	COG0667	Aldo Keto reductase
FPL03_RS17500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL03_RS17505	COG4771	TonB-dependent receptor
FPL03_RS17515	COG2827	Endonuclease containing a URI domain
FPL03_RS17560	COG1877	trehalose-phosphatase activity
FPL03_RS17585	COG0840	transmembrane signaling receptor activity
FPL03_RS17590	COG3011	Protein conserved in bacteria
FPL03_RS17605	COG0564	pseudouridine synthase activity
FPL03_RS17610	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL03_RS17620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FPL03_RS17620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPL03_RS17635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FPL03_RS17640	COG0045	succinate-CoA ligase (ADP-forming) activity
FPL03_RS17685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FPL03_RS17690	COG0237	dephospho-CoA kinase activity
FPL03_RS17710	COG5002	protein histidine kinase activity
FPL03_RS17715	COG0745	RESPONSE REGULATOR receiver
FPL03_RS17725	COG0189	ligase activity
FPL03_RS17835	COG3657	addiction module killer protein
FPL03_RS17865	COG3209	COG3209 Rhs family protein
FPL03_RS17915	COG2022	thiamine diphosphate biosynthetic process
FPL03_RS17925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FPL03_RS17930	COG0471	metal ion transport
FPL03_RS17930	COG3273	potassium ion transport
FPL03_RS18000	COG2205	protein histidine kinase activity
FPL03_RS18000	COG0784	Response regulator, receiver
FPL03_RS18005	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FPL03_RS18020	COG5297	Belongs to the glycosyl hydrolase family 6
FPL03_RS18030	COG3250	beta-galactosidase activity
FPL03_RS18035	COG4948	Mandelate Racemase Muconate Lactonizing
FPL03_RS18050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPL03_RS18060	COG0308	aminopeptidase N
FPL03_RS18065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL03_RS18075	COG0529	Catalyzes the synthesis of activated sulfate
FPL03_RS18075	COG2895	sulfate adenylyltransferase (ATP) activity
FPL03_RS18080	COG0175	sulfate reduction
FPL03_RS18085	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FPL03_RS18090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FPL03_RS18095	COG0175	sulfate reduction
FPL03_RS18115	COG2198	Histidine kinase
FPL03_RS18115	COG2205	protein histidine kinase activity
FPL03_RS18115	COG0784	Response regulator, receiver
FPL03_RS18135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FPL03_RS18135	COG1648	precorrin-2 dehydrogenase activity
FPL03_RS18150	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FPL03_RS18155	COG3588	fructose-bisphosphate aldolase
FPL03_RS18170	COG0469	pyruvate kinase activity
FPL03_RS18180	COG0126	phosphoglycerate kinase activity
FPL03_RS18205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FPL03_RS18215	COG3047	cAMP biosynthetic process
FPL03_RS18220	COG3047	cAMP biosynthetic process
FPL03_RS18230	COG3453	Protein conserved in bacteria
FPL03_RS18230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL03_RS18235	COG0725	ABC transporter, periplasmic molybdate-binding protein
FPL03_RS18240	COG4149	molybdate abc transporter
FPL03_RS18245	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FPL03_RS18280	COG1376	ErfK ybiS ycfS ynhG family protein
FPL03_RS18285	COG0739	heme binding
FPL03_RS18295	COG4773	Receptor
FPL03_RS18300	COG0596	Alpha beta hydrolase
FPL03_RS18305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FPL03_RS18310	COG1301	dicarboxylic acid transport
FPL03_RS18320	COG2304	oxidoreductase activity
FPL03_RS18340	COG0714	Associated with various cellular activities
FPL03_RS18370	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FPL03_RS18395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FPL03_RS18405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPL03_RS18415	COG0194	GDP metabolic process
FPL03_RS18420	COG1561	YicC-like family, N-terminal region
FPL03_RS18425	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FPL03_RS18435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FPL03_RS18440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FPL03_RS18455	COG0006	proline dipeptidase activity
FPL03_RS18465	COG0006	proline dipeptidase activity
FPL03_RS18470	COG3079	Belongs to the UPF0149 family
FPL03_RS18490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FPL03_RS18500	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FPL03_RS18510	COG2912	Transglutaminase-like superfamily
FPL03_RS18515	COG1773	rubredoxin
FPL03_RS18520	COG0352	thiamine-phosphate diphosphorylase activity
FPL03_RS18530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FPL03_RS18550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL03_RS18580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FPL03_RS18585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL03_RS18595	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS18605	COG0671	phosphoesterase, PA-phosphatase related
FPL03_RS18610	COG3781	membrane
FPL03_RS18620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPL03_RS18625	COG0563	adenylate kinase activity
FPL03_RS18640	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FPL03_RS18650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FPL03_RS18675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FPL03_RS18690	COG0840	transmembrane signaling receptor activity
FPL03_RS18695	COG0405	Gamma-glutamyltransferase
FPL03_RS18700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FPL03_RS18720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FPL03_RS18730	COG0473	3-isopropylmalate dehydrogenase activity
FPL03_RS18735	COG0066	3-isopropylmalate dehydratase activity
FPL03_RS18740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FPL03_RS18760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FPL03_RS18765	COG1538	Outer membrane efflux protein
FPL03_RS18770	COG1519	Transferase
FPL03_RS18780	COG1560	Kdo2-lipid A biosynthetic process
FPL03_RS18810	COG0281	malic enzyme
FPL03_RS18810	COG0280	phosphate acetyltransferase
FPL03_RS18815	COG1301	dicarboxylic acid transport
FPL03_RS18840	COG0583	DNA-binding transcription factor activity
FPL03_RS18850	COG0667	Aldo Keto reductase
FPL03_RS18865	COG2197	response regulator
FPL03_RS18875	COG0642	Histidine kinase
FPL03_RS18895	COG2851	Citrate transporter
FPL03_RS18900	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS18910	COG2211	Major facilitator Superfamily
FPL03_RS18935	COG1162	GTPase activity
FPL03_RS18970	COG4773	Receptor
FPL03_RS18975	COG0726	polysaccharide deacetylase
FPL03_RS18980	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FPL03_RS18995	COG3964	amidohydrolase
FPL03_RS19000	COG0402	S-adenosylhomocysteine deaminase activity
FPL03_RS19025	COG1307	EDD domain protein, DegV family
FPL03_RS19030	COG0242	peptide deformylase activity
FPL03_RS19065	COG0457	Tetratricopeptide repeat
FPL03_RS19070	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FPL03_RS19075	COG1215	transferase activity, transferring glycosyl groups
FPL03_RS19080	COG1215	transferase activity, transferring glycosyl groups
FPL03_RS19095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FPL03_RS19150	COG2188	Transcriptional regulator
FPL03_RS19170	COG1450	Type ii and iii secretion system protein
FPL03_RS19185	COG3166	PFAM Fimbrial assembly family protein
FPL03_RS19190	COG3156	type II secretion system protein K
FPL03_RS19195	COG4795	General secretion pathway protein
FPL03_RS19200	COG2165	general secretion pathway protein
FPL03_RS19205	COG4970	Tfp pilus assembly protein FimT
FPL03_RS19210	COG2165	general secretion pathway protein
FPL03_RS19215	COG1459	type II secretion system
FPL03_RS19220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FPL03_RS19225	COG1404	Belongs to the peptidase S8 family
FPL03_RS19230	COG5295	Hep Hag repeat protein
FPL03_RS19235	COG1404	Belongs to the peptidase S8 family
FPL03_RS19240	COG5295	Hep Hag repeat protein
FPL03_RS19250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FPL03_RS19250	COG0047	phosphoribosylformylglycinamidine synthase activity
FPL03_RS19265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL03_RS19280	COG4974	Belongs to the 'phage' integrase family
FPL03_RS19295	COG0795	lipopolysaccharide-transporting ATPase activity
FPL03_RS19305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FPL03_RS19320	COG0525	valine-tRNA ligase activity
FPL03_RS19350	COG1183	phosphatidylcholine synthase activity
FPL03_RS19360	COG0442	prolyl-tRNA aminoacylation
FPL03_RS19375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPL03_RS19380	COG1127	ABC transporter
FPL03_RS19385	COG3218	ABC-type transport auxiliary lipoprotein component
FPL03_RS19385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPL03_RS19415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FPL03_RS19420	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FPL03_RS19420	COG0662	Cupin 2, conserved barrel domain protein
FPL03_RS19450	COG2086	electron transfer activity
FPL03_RS19465	COG0463	Glycosyl transferase, family 2
FPL03_RS19485	COG2813	Specifically methylates the guanine in position
FPL03_RS19500	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FPL03_RS19505	COG0438	transferase activity, transferring glycosyl groups
FPL03_RS19525	COG0438	transferase activity, transferring glycosyl groups
FPL03_RS19535	COG0626	cystathionine gamma-synthase activity
FPL03_RS19565	COG0625	glutathione transferase activity
FPL03_RS19580	COG0513	Belongs to the DEAD box helicase family
FPL03_RS19590	COG4206	TonB-dependent receptor
FPL03_RS19600	COG0720	synthase
FPL03_RS19610	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FPL03_RS19620	COG1956	GAF domain-containing protein
FPL03_RS19630	COG2819	hydrolase of the alpha beta superfamily
FPL03_RS19640	COG0546	phosphoglycolate phosphatase activity
FPL03_RS19645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FPL03_RS19650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPL03_RS19665	COG0339	signal peptide processing
FPL03_RS19720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPL03_RS19725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL03_RS19730	COG4591	ABC-type transport system involved in lipoprotein release permease component
FPL03_RS19730	COG1136	(ABC) transporter
FPL03_RS19735	COG0577	efflux transmembrane transporter activity
FPL03_RS19755	COG4191	Histidine kinase
FPL03_RS19760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FPL03_RS19775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FPL03_RS19780	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FPL03_RS19785	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FPL03_RS19790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FPL03_RS19795	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FPL03_RS19800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FPL03_RS19810	COG0356	it plays a direct role in the translocation of protons across the membrane
FPL03_RS19830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL03_RS19840	COG0508	dehydrogenase complex catalyzes the overall conversion of
FPL03_RS19880	COG2011	ABC-type metal ion transport system permease component
FPL03_RS19885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FPL03_RS19890	COG0697	spore germination
FPL03_RS19895	COG1666	GTP binding
FPL03_RS19905	COG5002	protein histidine kinase activity
FPL03_RS19905	COG2198	Histidine kinase
FPL03_RS19905	COG0784	Response regulator, receiver
FPL03_RS19930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FPL03_RS19940	COG2813	Specifically methylates the guanine in position
FPL03_RS19960	COG2202	Pas domain
FPL03_RS19960	COG2205	protein histidine kinase activity
FPL03_RS19980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FPL03_RS19985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL03_RS20040	COG0842	Transport permease protein
FPL03_RS20045	COG1131	(ABC) transporter
FPL03_RS20050	COG0025	NhaP-type Na H and K H
FPL03_RS20060	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FPL03_RS20065	COG1573	uracil-dna glycosylase
FPL03_RS20075	COG3384	dioxygenase
FPL03_RS20085	COG0583	DNA-binding transcription factor activity
FPL03_RS20095	COG0667	Aldo Keto reductase
FPL03_RS20110	COG3590	peptidase
FPL03_RS20130	COG0531	amino acid
FPL03_RS20145	COG2972	Histidine kinase
FPL03_RS20170	COG3685	Protein conserved in bacteria
FPL03_RS20175	COG3546	catalase activity
FPL03_RS20225	COG1271	oxidase subunit
FPL03_RS20230	COG1294	oxidase, subunit
FPL03_RS20245	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS20250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FPL03_RS20270	COG1132	(ABC) transporter
FPL03_RS20285	COG1063	alcohol dehydrogenase
FPL03_RS20360	COG0251	oxidation-reduction process
FPL03_RS20375	COG0840	transmembrane signaling receptor activity
FPL03_RS20390	COG0583	DNA-binding transcription factor activity
FPL03_RS20395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FPL03_RS20440	COG0024	Methionine aminopeptidase
FPL03_RS20545	COG0582	viral genome integration into host DNA
FPL03_RS20585	COG4695	Portal protein
FPL03_RS20630	COG3179	chitinase
FPL03_RS20825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FPL03_RS20830	COG1490	D-aminoacyl-tRNA deacylase activity
FPL03_RS20835	COG1560	Kdo2-lipid A biosynthetic process
FPL03_RS20890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FPL03_RS20890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FPL03_RS20895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FPL03_RS20900	COG0242	peptide deformylase activity
FPL03_RS20905	COG1652	LysM domain
FPL03_RS20910	COG0758	DNA mediated transformation
FPL03_RS20930	COG1754	DNA topoisomerase type I activity
FPL03_RS20930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FPL03_RS20935	COG0009	L-threonylcarbamoyladenylate synthase
FPL03_RS20950	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS20965	COG0616	signal peptide processing
FPL03_RS20970	COG0534	Mate efflux family protein
FPL03_RS20990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FPL03_RS20995	COG0625	glutathione transferase activity
FPL03_RS21010	COG1252	NADH dehydrogenase
FPL03_RS21015	COG2860	membrane
FPL03_RS21020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FPL03_RS21025	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FPL03_RS21030	COG3437	response regulator, receiver
FPL03_RS21035	COG2177	Part of the ABC transporter FtsEX involved in
FPL03_RS21040	COG2884	Cell division ATP-binding protein ftsE
FPL03_RS21050	COG3118	belongs to the thioredoxin family
FPL03_RS21055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FPL03_RS21060	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FPL03_RS21065	COG0583	DNA-binding transcription factor activity
FPL03_RS21085	COG1652	LysM domain
FPL03_RS21090	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FPL03_RS21090	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FPL03_RS21095	COG1473	amidohydrolase
FPL03_RS21100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL03_RS21105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL03_RS21115	COG5383	Protein conserved in bacteria
FPL03_RS21160	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FPL03_RS21165	COG3023	N-Acetylmuramoyl-L-alanine amidase
FPL03_RS21175	COG4948	Mandelate Racemase Muconate Lactonizing
FPL03_RS21185	COG0531	amino acid
FPL03_RS21200	COG4682	membrane
FPL03_RS21215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FPL03_RS21220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FPL03_RS21230	COG1610	YqeY-like protein
FPL03_RS21240	COG1295	ribonuclease BN
FPL03_RS21245	COG0358	DNA primase activity
FPL03_RS21260	COG0109	protoheme IX farnesyltransferase activity
FPL03_RS21290	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FPL03_RS21305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FPL03_RS21350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FPL03_RS21355	COG0739	heme binding
FPL03_RS21360	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FPL03_RS21370	COG2211	Major facilitator Superfamily
FPL03_RS21375	COG0708	Exodeoxyribonuclease III
FPL03_RS21380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FPL03_RS21390	COG1192	Involved in chromosome partitioning
FPL03_RS21395	COG1475	DNA binding
FPL03_RS21415	COG0463	Glycosyl transferase, family 2
FPL03_RS21435	COG0756	dUTP diphosphatase activity
FPL03_RS21440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FPL03_RS21445	COG2003	Belongs to the UPF0758 family
FPL03_RS21450	COG0018	arginyl-trna synthetase
FPL03_RS21465	COG4221	oxidoreductase activity
FPL03_RS21480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL03_RS21485	COG1166	arginine decarboxylase activity
FPL03_RS21490	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FPL03_RS21515	COG3291	Pkd domain containing protein
FPL03_RS21515	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FPL03_RS21525	COG0347	Belongs to the P(II) protein family
FPL03_RS21535	COG0606	chelatase, subunit chli
FPL03_RS21550	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FPL03_RS21585	COG1690	Belongs to the RtcB family
FPL03_RS21620	COG1090	epimerase
FPL03_RS21630	COG0642	Histidine kinase
FPL03_RS21660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FPL03_RS21685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FPL03_RS21690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FPL03_RS21705	COG0753	catalase activity
FPL03_RS21720	COG2197	response regulator
FPL03_RS21725	COG4585	Histidine kinase
FPL03_RS21730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL03_RS21735	COG1136	(ABC) transporter
FPL03_RS21760	COG0697	spore germination
FPL03_RS21780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL03_RS21785	COG0180	Tryptophanyl-tRNA synthetase
FPL03_RS21790	COG3237	CsbD-like
FPL03_RS21835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FPL03_RS21870	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FPL03_RS21875	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FPL03_RS21875	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FPL03_RS21920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPL03_RS21950	COG1199	ATP-dependent helicase activity
FPL03_RS21965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FPL03_RS22030	COG0625	glutathione transferase activity
FPL03_RS22070	COG4555	ABC transporter
FPL03_RS22080	COG1476	TRANSCRIPTIONal
FPL03_RS22125	COG0543	2 iron, 2 sulfur cluster binding
FPL03_RS22125	COG0633	Ferredoxin
FPL03_RS22130	COG1131	(ABC) transporter
FPL03_RS22135	COG0842	Transport permease protein
FPL03_RS22145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FPL03_RS22180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FPL03_RS22190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FPL03_RS22205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FPL03_RS22205	COG0045	succinate-CoA ligase (ADP-forming) activity
FPL03_RS22205	COG1042	CoA-binding domain protein
FPL03_RS22210	COG2239	Acts as a magnesium transporter
FPL03_RS22230	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FPL03_RS22235	COG3387	PFAM Glycoside hydrolase 15-related
FPL03_RS22250	COG3100	YcgL domain-containing protein
FPL03_RS22255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FPL03_RS22265	COG0463	Glycosyl transferase, family 2
FPL03_RS22275	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS22310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPL03_RS22325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPL03_RS22355	COG0823	Involved in the tonB-independent uptake of proteins
FPL03_RS22355	COG1506	peptidase
FPL03_RS22355	COG4946	Tricorn protease homolog
FPL03_RS22375	COG0408	coproporphyrinogen oxidase activity
FPL03_RS22415	COG0515	serine threonine protein kinase
FPL03_RS22415	COG2815	serine threonine protein kinase
FPL03_RS22420	COG0631	protein serine/threonine phosphatase activity
FPL03_RS22630	COG0210	DNA helicase
FPL03_RS22645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL03_RS22650	COG0583	DNA-binding transcription factor activity
FPL03_RS22655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FPL03_RS22670	COG2159	amidohydrolase
FPL03_RS22695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL03_RS22715	COG0357	Ribosomal RNA small subunit methyltransferase G
FPL03_RS22720	COG3540	Alkaline phosphatase
FPL03_RS22730	COG2091	lysine biosynthetic process via aminoadipic acid
FPL03_RS22745	COG0708	Exodeoxyribonuclease III
FPL03_RS22750	COG1940	carbohydrate kinase activity
FPL03_RS22750	COG1846	Transcriptional regulator
FPL03_RS22760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL03_RS22770	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FPL03_RS22775	COG3162	membrane
FPL03_RS22785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FPL03_RS22815	COG3507	Belongs to the glycosyl hydrolase 43 family
FPL03_RS22835	COG1028	Short-chain dehydrogenase reductase Sdr
FPL03_RS22840	COG0179	Fumarylacetoacetate (FAA) hydrolase
FPL03_RS22850	COG4948	Mandelate Racemase Muconate Lactonizing
FPL03_RS22855	COG3254	rhamnose metabolic process
FPL03_RS22860	COG0738	Major facilitator superfamily
FPL03_RS22865	COG1414	Transcriptional regulator
FPL03_RS22870	COG1971	Probably functions as a manganese efflux pump
FPL03_RS22875	COG2205	protein histidine kinase activity
FPL03_RS22890	COG3459	Glycosyltransferase 36 associated
FPL03_RS22895	COG2211	Major facilitator Superfamily
FPL03_RS22900	COG3265	gluconokinase activity
FPL03_RS22910	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL03_RS22930	COG2911	Protein conserved in bacteria
FPL03_RS22935	COG0729	surface antigen
FPL03_RS22970	COG0752	glycyl-tRNA synthetase alpha subunit
FPL03_RS22975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FPL03_RS22990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FPL03_RS22990	COG0519	Catalyzes the synthesis of GMP from XMP
FPL03_RS23000	COG0805	protein transport
FPL03_RS23005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FPL03_RS23010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FPL03_RS23020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FPL03_RS23045	COG2974	May be involved in recombination
FPL03_RS23050	COG0037	tRNA processing
FPL03_RS23060	COG2115	Belongs to the xylose isomerase family
FPL03_RS23070	COG3661	Belongs to the glycosyl hydrolase 67 family
FPL03_RS23080	COG4948	Mandelate Racemase Muconate Lactonizing
FPL03_RS23090	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL03_RS23095	COG0246	Mannitol dehydrogenase
FPL03_RS23145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FPL03_RS23175	COG3386	PFAM SMP-30 Gluconolaconase
FPL03_RS23185	COG3250	beta-galactosidase activity
FPL03_RS23190	COG1904	glucuronate isomerase
FPL03_RS23195	COG3693	PFAM glycoside hydrolase, family 10
FPL03_RS23205	COG3693	PFAM glycoside hydrolase, family 10
FPL03_RS23220	COG2211	Major facilitator Superfamily
FPL03_RS23260	COG2937	Belongs to the GPAT DAPAT family
FPL03_RS23295	COG0284	orotidine-5'-phosphate decarboxylase activity
FPL03_RS23300	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FPL03_RS23310	COG3132	Protein of unknown function, DUF480
FPL03_RS23325	COG0210	DNA helicase
FPL03_RS23330	COG1435	thymidine kinase activity
FPL03_RS23340	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FPL03_RS23350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FPL03_RS23380	COG3135	benzoate transporter
FPL03_RS23400	COG0676	glucose-6-phosphate 1-epimerase activity
FPL03_RS23410	COG3012	SEC-C Motif Domain Protein
FPL03_RS23415	COG0730	response to heat
FPL03_RS23435	COG0302	gtp cyclohydrolase
FPL03_RS23450	COG1566	PFAM secretion protein HlyD family protein
FPL03_RS23460	COG1289	transmembrane transporter activity
FPL03_RS23465	COG0477	Major facilitator Superfamily
FPL03_RS23475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL03_RS23495	COG4691	Plasmid stability protein
FPL03_RS23500	COG1487	ribonuclease activity
FPL03_RS23535	COG0564	pseudouridine synthase activity
FPL03_RS23550	COG0439	Biotin carboxylase
FPL03_RS23590	COG1074	ATP-dependent DNA helicase activity
FPL03_RS23595	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FPL03_RS23610	COG1127	ABC transporter
FPL03_RS23615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPL03_RS23620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPL03_RS23635	COG2853	Lipoprotein
FPL03_RS23645	COG0386	Belongs to the glutathione peroxidase family
FPL03_RS23655	COG1322	Protein conserved in bacteria
FPL03_RS23660	COG0604	alcohol dehydrogenase
FPL03_RS23665	COG0583	DNA-binding transcription factor activity
FPL03_RS23680	COG0625	glutathione transferase activity
FPL03_RS23690	COG0531	amino acid
FPL03_RS23695	COG3537	Alpha-1,2-mannosidase
FPL03_RS23710	COG3706	GGDEF domain
FPL03_RS23715	COG3835	regulator
FPL03_RS23720	COG1929	Belongs to the glycerate kinase type-1 family
FPL03_RS23725	COG2271	Major facilitator Superfamily
FPL03_RS23740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FPL03_RS23750	COG0861	Integral membrane protein TerC family
FPL03_RS23765	COG0584	glycerophosphoryl diester phosphodiesterase
FPL03_RS23780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FPL03_RS23785	COG0726	polysaccharide deacetylase
FPL03_RS23790	COG0706	membrane insertase activity
FPL03_RS23795	COG0594	ribonuclease P activity
FPL03_RS23845	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FPL03_RS23855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FPL03_RS23945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FPL03_RS23975	COG1475	DNA binding
FPL03_RS24095	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs