locus-tag	class	description
FPL05_RS00060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FPL05_RS00180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FPL05_RS00185	COG0187	DNA topoisomerase II activity
FPL05_RS00195	COG0501	Belongs to the peptidase M48B family
FPL05_RS00225	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FPL05_RS00235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL05_RS00280	COG0793	Belongs to the peptidase S41A family
FPL05_RS00285	COG4942	peptidase
FPL05_RS00295	COG2234	aminopeptidase activity
FPL05_RS00305	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL05_RS00315	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL05_RS00320	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL05_RS00330	COG1064	alcohol dehydrogenase
FPL05_RS00340	COG0493	'glutamate synthase
FPL05_RS00345	COG0067	glutamate synthase
FPL05_RS00345	COG0069	glutamate synthase activity
FPL05_RS00345	COG0070	glutamate synthase
FPL05_RS00395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FPL05_RS00410	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FPL05_RS00415	COG0297	glycogen (starch) synthase activity
FPL05_RS00415	COG0438	transferase activity, transferring glycosyl groups
FPL05_RS00435	COG0367	asparagine synthase
FPL05_RS00465	COG1132	(ABC) transporter
FPL05_RS00495	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FPL05_RS00590	COG1205	dead DEAH box helicase
FPL05_RS00590	COG1111	helicase
FPL05_RS00595	COG1272	protein, Hemolysin III
FPL05_RS00620	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS00645	COG2249	NAD(P)H dehydrogenase (quinone) activity
FPL05_RS00655	COG3237	CsbD-like
FPL05_RS00700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL05_RS00710	COG0477	Major facilitator Superfamily
FPL05_RS00750	COG0714	Associated with various cellular activities
FPL05_RS00780	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FPL05_RS00790	COG4772	TonB-dependent receptor
FPL05_RS00800	COG0662	Cupin 2, conserved barrel domain protein
FPL05_RS00805	COG1012	belongs to the aldehyde dehydrogenase family
FPL05_RS00830	COG1304	FMN binding
FPL05_RS00845	COG4585	Histidine kinase
FPL05_RS00850	COG2197	response regulator
FPL05_RS00870	COG3710	Transcriptional regulator
FPL05_RS00875	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FPL05_RS00910	COG2131	deaminase
FPL05_RS00955	COG0366	Alpha amylase catalytic
FPL05_RS00960	COG0366	Alpha amylase catalytic
FPL05_RS00965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL05_RS00990	COG2755	lipolytic protein G-D-S-L family
FPL05_RS00990	COG0657	acetylesterase activity
FPL05_RS01000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FPL05_RS01015	COG3507	Belongs to the glycosyl hydrolase 43 family
FPL05_RS01020	COG1609	Transcriptional regulator
FPL05_RS01040	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FPL05_RS01045	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS01055	COG2755	lipolytic protein G-D-S-L family
FPL05_RS01070	COG3186	Phenylalanine-4-hydroxylase
FPL05_RS01075	COG1522	sequence-specific DNA binding
FPL05_RS01085	COG1752	Esterase of the alpha-beta hydrolase superfamily
FPL05_RS01095	COG1119	ATPase activity
FPL05_RS01110	COG1125	glycine betaine transport
FPL05_RS01125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FPL05_RS01145	COG3550	peptidyl-serine autophosphorylation
FPL05_RS01150	COG1396	sequence-specific DNA binding
FPL05_RS01175	COG0489	protein tyrosine kinase activity
FPL05_RS01180	COG2062	phosphohistidine phosphatase, SixA
FPL05_RS01190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL05_RS01240	COG1968	undecaprenyl-diphosphatase activity
FPL05_RS01250	COG0174	glutamine synthetase
FPL05_RS01255	COG0347	Belongs to the P(II) protein family
FPL05_RS01260	COG0004	ammonium transporteR
FPL05_RS01265	COG3852	Histidine kinase
FPL05_RS01270	COG2204	response regulator
FPL05_RS01275	COG2032	superoxide dismutase activity
FPL05_RS01280	COG2032	superoxide dismutase activity
FPL05_RS01290	COG0346	lactoylglutathione lyase activity
FPL05_RS01300	COG0183	Belongs to the thiolase family
FPL05_RS01335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FPL05_RS01340	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FPL05_RS01345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FPL05_RS01400	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FPL05_RS01405	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FPL05_RS01410	COG4786	Flagellar basal body rod
FPL05_RS01415	COG4786	Flagellar basal body rod
FPL05_RS01425	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FPL05_RS01430	COG1706	bacterial-type flagellum-dependent cell motility
FPL05_RS01445	COG1677	Flagellar hook-basal body complex protein FliE
FPL05_RS01465	COG1157	protein secretion by the type III secretion system
FPL05_RS01480	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FPL05_RS01515	COG0028	Belongs to the TPP enzyme family
FPL05_RS01520	COG2205	protein histidine kinase activity
FPL05_RS01545	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FPL05_RS01560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL05_RS01570	COG0596	Alpha beta hydrolase
FPL05_RS01575	COG0727	PFAM Uncharacterised protein family (UPF0153)
FPL05_RS01580	COG0318	PFAM AMP-dependent synthetase and ligase
FPL05_RS01585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL05_RS01610	COG1181	Belongs to the D-alanine--D-alanine ligase family
FPL05_RS01620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPL05_RS01630	COG0564	pseudouridine synthase activity
FPL05_RS01650	COG1446	asparaginase
FPL05_RS01655	COG0339	signal peptide processing
FPL05_RS01690	COG0475	glutathione-regulated potassium exporter activity
FPL05_RS01695	COG0583	DNA-binding transcription factor activity
FPL05_RS01700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FPL05_RS01705	COG2224	Isocitrate lyase
FPL05_RS01735	COG4770	biotin carboxylase activity
FPL05_RS01740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FPL05_RS01745	COG1960	acyl-CoA dehydrogenase activity
FPL05_RS01800	COG0523	cobalamin synthesis protein
FPL05_RS01810	COG0697	spore germination
FPL05_RS01820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FPL05_RS01825	COG1846	Transcriptional regulator
FPL05_RS01830	COG1764	response to oxidative stress
FPL05_RS01860	COG2130	NADP-dependent
FPL05_RS01875	COG1187	pseudouridine synthase activity
FPL05_RS01890	COG1643	Atp-dependent helicase
FPL05_RS01900	COG4807	Protein conserved in bacteria
FPL05_RS01905	COG2351	hydroxyisourate hydrolase activity
FPL05_RS01910	COG2072	flavoprotein involved in K transport
FPL05_RS01930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FPL05_RS01965	COG1957	nucleoside hydrolase
FPL05_RS01975	COG2252	PERMEase
FPL05_RS02000	COG0084	hydrolase, TatD family'
FPL05_RS02015	COG0583	DNA-binding transcription factor activity
FPL05_RS02020	COG2814	Major facilitator Superfamily
FPL05_RS02035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FPL05_RS02040	COG1902	pentaerythritol trinitrate reductase activity
FPL05_RS02060	COG0745	RESPONSE REGULATOR receiver
FPL05_RS02065	COG2205	protein histidine kinase activity
FPL05_RS02070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL05_RS02095	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FPL05_RS02100	COG0583	DNA-binding transcription factor activity
FPL05_RS02135	COG0702	epimerase
FPL05_RS02140	COG1733	regulation of RNA biosynthetic process
FPL05_RS02230	COG0129	dihydroxy-acid dehydratase activity
FPL05_RS02245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FPL05_RS02305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FPL05_RS02310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FPL05_RS02335	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FPL05_RS02340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FPL05_RS02350	COG3485	protocatechuate 3,4-dioxygenase
FPL05_RS02355	COG3485	protocatechuate 3,4-dioxygenase
FPL05_RS02365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL05_RS02370	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FPL05_RS02385	COG1414	Transcriptional regulator
FPL05_RS02395	COG0657	acetylesterase activity
FPL05_RS02405	COG0445	tRNA wobble uridine modification
FPL05_RS02415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FPL05_RS02445	COG2267	carboxylic ester hydrolase activity
FPL05_RS02455	COG0156	8-amino-7-oxononanoate synthase activity
FPL05_RS02460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FPL05_RS02465	COG1040	competence protein
FPL05_RS02470	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FPL05_RS02560	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FPL05_RS02645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPL05_RS02655	COG2354	Protein conserved in bacteria
FPL05_RS02665	COG0297	glycogen (starch) synthase activity
FPL05_RS02670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL05_RS02675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL05_RS02700	COG0702	epimerase
FPL05_RS02705	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS02735	COG0513	Belongs to the DEAD box helicase family
FPL05_RS02740	COG0508	dehydrogenase complex catalyzes the overall conversion of
FPL05_RS02755	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FPL05_RS02765	COG3483	tryptophan 2,3-dioxygenase activity
FPL05_RS02770	COG3104	oligopeptide transport
FPL05_RS02790	COG2852	Protein conserved in bacteria
FPL05_RS02795	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FPL05_RS02815	COG1320	monovalent cation:proton antiporter activity
FPL05_RS02820	COG2212	antiporter activity
FPL05_RS02830	COG0651	ATP synthesis coupled electron transport
FPL05_RS02835	COG1006	Multisubunit Na H antiporter MnhC subunit
FPL05_RS02840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FPL05_RS02840	COG2111	Na H antiporter
FPL05_RS02865	COG3179	chitinase
FPL05_RS02885	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FPL05_RS02890	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FPL05_RS02905	COG0456	acetyltransferase
FPL05_RS02910	COG1597	lipid kinase activity
FPL05_RS02940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FPL05_RS02945	COG0134	indole-3-glycerol-phosphate synthase activity
FPL05_RS02955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL05_RS02960	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FPL05_RS02970	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FPL05_RS02980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FPL05_RS02995	COG1051	belongs to the nudix hydrolase family
FPL05_RS03035	COG0316	Belongs to the HesB IscA family
FPL05_RS03055	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FPL05_RS03070	COG2814	Major facilitator Superfamily
FPL05_RS03080	COG2814	Major facilitator Superfamily
FPL05_RS03085	COG1289	transmembrane transporter activity
FPL05_RS03095	COG0151	Belongs to the GarS family
FPL05_RS03105	COG0138	bifunctional purine biosynthesis protein purh
FPL05_RS03110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FPL05_RS03115	COG2267	carboxylic ester hydrolase activity
FPL05_RS03120	COG2453	phosphatase
FPL05_RS03120	COG0671	phosphoesterase, PA-phosphatase related
FPL05_RS03145	COG4589	Belongs to the CDS family
FPL05_RS03150	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FPL05_RS03180	COG2264	protein methyltransferase activity
FPL05_RS03205	COG0439	Biotin carboxylase
FPL05_RS03215	COG0511	ligase activity, forming carbon-carbon bonds
FPL05_RS03220	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FPL05_RS03230	COG1324	tolerance protein
FPL05_RS03260	COG0300	oxidoreductase activity
FPL05_RS03265	COG2356	endonuclease I
FPL05_RS03280	COG0459	protein refolding
FPL05_RS03295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FPL05_RS03310	COG3386	PFAM SMP-30 Gluconolaconase
FPL05_RS03320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FPL05_RS03325	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FPL05_RS03345	COG0778	Nitroreductase
FPL05_RS03350	COG2353	YceI-like domain
FPL05_RS03380	COG3052	prosthetic group binding
FPL05_RS03415	COG1802	Transcriptional regulator
FPL05_RS03545	COG4221	oxidoreductase activity
FPL05_RS03560	COG4221	oxidoreductase activity
FPL05_RS03570	COG0435	Glutathione S-transferase
FPL05_RS03590	COG2409	Drug exporters of the RND superfamily
FPL05_RS03600	COG1506	peptidase
FPL05_RS03600	COG0823	Involved in the tonB-independent uptake of proteins
FPL05_RS03640	COG0697	spore germination
FPL05_RS03655	COG1113	amino acid transport
FPL05_RS03675	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FPL05_RS03720	COG5001	Diguanylate cyclase
FPL05_RS03725	COG0840	transmembrane signaling receptor activity
FPL05_RS03730	COG5297	Belongs to the glycosyl hydrolase family 6
FPL05_RS03730	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL05_RS03735	COG0659	secondary active sulfate transmembrane transporter activity
FPL05_RS03765	COG2943	transferase activity, transferring hexosyl groups
FPL05_RS03775	COG3275	phosphorelay sensor kinase activity
FPL05_RS03785	COG0181	hydroxymethylbilane synthase activity
FPL05_RS03815	COG1505	serine-type exopeptidase activity
FPL05_RS03825	COG0436	Aminotransferase
FPL05_RS03835	COG2832	Protein of unknown function (DUF454)
FPL05_RS03845	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FPL05_RS03855	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FPL05_RS03860	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FPL05_RS03865	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FPL05_RS03890	COG2226	methyltransferase
FPL05_RS03895	COG3300	MHYT domain
FPL05_RS03895	COG5001	Diguanylate cyclase
FPL05_RS03900	COG0308	aminopeptidase N
FPL05_RS03950	COG3284	Transcriptional regulator
FPL05_RS03955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPL05_RS03960	COG1077	Cell shape determining protein MreB Mrl
FPL05_RS03980	COG0772	Belongs to the SEDS family
FPL05_RS03990	COG2951	lytic endotransglycosylase activity
FPL05_RS03995	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FPL05_RS04005	COG1686	Belongs to the peptidase S11 family
FPL05_RS04015	COG2921	Belongs to the UPF0250 family
FPL05_RS04020	COG0321	lipoyl(octanoyl) transferase activity
FPL05_RS04025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FPL05_RS04040	COG0583	DNA-binding transcription factor activity
FPL05_RS04050	COG1056	cytidyltransferase-related domain
FPL05_RS04050	COG1051	belongs to the nudix hydrolase family
FPL05_RS04085	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FPL05_RS04090	COG0673	inositol 2-dehydrogenase activity
FPL05_RS04095	COG2823	Periplasmic or secreted lipoprotein
FPL05_RS04100	COG4251	negative regulation of phosphorylation
FPL05_RS04105	COG0784	Response regulator, receiver
FPL05_RS04110	COG4191	Histidine kinase
FPL05_RS04115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FPL05_RS04175	COG1459	type II secretion system
FPL05_RS04195	COG4795	General secretion pathway protein
FPL05_RS04225	COG3250	beta-galactosidase activity
FPL05_RS04240	COG2188	Transcriptional regulator
FPL05_RS04250	COG1609	Transcriptional regulator
FPL05_RS04255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPL05_RS04260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FPL05_RS04270	COG0617	tRNA 3'-terminal CCA addition
FPL05_RS04275	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FPL05_RS04280	COG1012	belongs to the aldehyde dehydrogenase family
FPL05_RS04285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FPL05_RS04300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL05_RS04315	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FPL05_RS04320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FPL05_RS04340	COG2205	protein histidine kinase activity
FPL05_RS04370	COG3791	Glutathione-dependent formaldehyde-activating
FPL05_RS04385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL05_RS04405	COG0488	(ABC) transporter
FPL05_RS04415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FPL05_RS04420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FPL05_RS04430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPL05_RS04430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPL05_RS04450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FPL05_RS04455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FPL05_RS04460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FPL05_RS04485	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FPL05_RS04490	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FPL05_RS04495	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FPL05_RS04500	COG2205	protein histidine kinase activity
FPL05_RS04505	COG0745	RESPONSE REGULATOR receiver
FPL05_RS04520	COG0277	FAD linked oxidase domain protein
FPL05_RS04525	COG1988	membrane-bound metal-dependent
FPL05_RS04530	COG0792	nuclease activity
FPL05_RS04570	COG0275	rRNA processing
FPL05_RS04575	COG3116	cell division
FPL05_RS04585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FPL05_RS04590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FPL05_RS04595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FPL05_RS04605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FPL05_RS04610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPL05_RS04615	COG1181	Belongs to the D-alanine--D-alanine ligase family
FPL05_RS04620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FPL05_RS04635	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FPL05_RS04645	COG0739	heme binding
FPL05_RS04650	COG0653	protein targeting
FPL05_RS04655	COG0494	nUDIX hydrolase
FPL05_RS04665	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FPL05_RS04680	COG0604	alcohol dehydrogenase
FPL05_RS04680	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS04680	COG3321	synthase
FPL05_RS04715	COG0366	Alpha amylase catalytic
FPL05_RS04740	COG2226	methyltransferase
FPL05_RS04745	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FPL05_RS04755	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FPL05_RS04795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FPL05_RS04805	COG4106	trans-aconitate 2-methyltransferase activity
FPL05_RS04810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPL05_RS04820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPL05_RS04825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FPL05_RS04835	COG0667	Aldo Keto reductase
FPL05_RS04845	COG4771	TonB-dependent receptor
FPL05_RS04865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL05_RS04870	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FPL05_RS04880	COG2175	clavaminate synthase activity
FPL05_RS04890	COG4181	ATPase activity
FPL05_RS04905	COG0642	Histidine kinase
FPL05_RS04915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FPL05_RS04935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FPL05_RS04940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FPL05_RS04955	COG3829	transcription factor binding
FPL05_RS04965	COG1116	anion transmembrane transporter activity
FPL05_RS04970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL05_RS04980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL05_RS04985	COG0431	NADPH-dependent FMN reductase
FPL05_RS05015	COG0747	negative chemotaxis
FPL05_RS05025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FPL05_RS05035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FPL05_RS05040	COG2967	ApaG domain
FPL05_RS05045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FPL05_RS05050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FPL05_RS05055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL05_RS05060	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FPL05_RS05065	COG0123	including yeast histone deacetylase and acetoin utilization protein
FPL05_RS05070	COG2096	Adenosyltransferase
FPL05_RS05085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL05_RS05090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL05_RS05120	COG3384	dioxygenase
FPL05_RS05125	COG0583	DNA-binding transcription factor activity
FPL05_RS05140	COG1024	Enoyl-CoA hydratase
FPL05_RS05160	COG3386	PFAM SMP-30 Gluconolaconase
FPL05_RS05175	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FPL05_RS05195	COG0697	spore germination
FPL05_RS05205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL05_RS05230	COG2197	response regulator
FPL05_RS05240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FPL05_RS05250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FPL05_RS05255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL05_RS05265	COG0583	DNA-binding transcription factor activity
FPL05_RS05270	COG3634	alkyl hydroperoxide reductase activity
FPL05_RS05280	COG2890	protein-(glutamine-N5) methyltransferase activity
FPL05_RS05300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL05_RS05300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL05_RS05330	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FPL05_RS05355	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FPL05_RS05370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FPL05_RS05375	COG1404	Belongs to the peptidase S8 family
FPL05_RS05380	COG1404	Belongs to the peptidase S8 family
FPL05_RS05385	COG1404	Belongs to the peptidase S8 family
FPL05_RS05390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FPL05_RS05415	COG1295	ribonuclease BN
FPL05_RS05420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL05_RS05425	COG1254	Belongs to the acylphosphatase family
FPL05_RS05440	COG0521	Mo-molybdopterin cofactor biosynthetic process
FPL05_RS05450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FPL05_RS05455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FPL05_RS05465	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FPL05_RS05470	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FPL05_RS05480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FPL05_RS05485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FPL05_RS05490	COG0193	aminoacyl-tRNA hydrolase activity
FPL05_RS05495	COG0012	GTP binding
FPL05_RS05515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FPL05_RS05530	COG0250	Participates in transcription elongation, termination and antitermination
FPL05_RS05535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FPL05_RS05540	COG0081	regulation of translation
FPL05_RS05545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FPL05_RS05550	COG0222	ribosome binding
FPL05_RS05555	COG0085	RNA polymerase activity
FPL05_RS05560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FPL05_RS05565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FPL05_RS05570	COG0049	tRNA binding
FPL05_RS05575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FPL05_RS05580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FPL05_RS05585	COG0051	transcription antitermination factor activity, RNA binding
FPL05_RS05590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FPL05_RS05595	COG0088	Forms part of the polypeptide exit tunnel
FPL05_RS05600	COG0089	rRNA binding
FPL05_RS05605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FPL05_RS05610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FPL05_RS05620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FPL05_RS05625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FPL05_RS05630	COG0255	Belongs to the universal ribosomal protein uL29 family
FPL05_RS05635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FPL05_RS05645	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FPL05_RS05650	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FPL05_RS05660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FPL05_RS05665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FPL05_RS05670	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FPL05_RS05680	COG1841	ribosomal large subunit assembly
FPL05_RS05685	COG0200	Binds to the 23S rRNA
FPL05_RS05690	COG0201	protein transport
FPL05_RS05715	COG0203	ribosomal protein L17
FPL05_RS05720	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FPL05_RS05740	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FPL05_RS05750	COG0154	amidase activity
FPL05_RS05760	COG1217	gtp-binding protein TYPA
FPL05_RS05765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FPL05_RS05770	COG0039	L-malate dehydrogenase activity
FPL05_RS05775	COG0625	glutathione transferase activity
FPL05_RS05795	COG1902	pentaerythritol trinitrate reductase activity
FPL05_RS05795	COG0446	pyridine nucleotide-disulphide oxidoreductase
FPL05_RS05800	COG0604	alcohol dehydrogenase
FPL05_RS05830	COG0156	8-amino-7-oxononanoate synthase activity
FPL05_RS05835	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FPL05_RS05840	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FPL05_RS05845	COG4208	sulfate ABC transporter
FPL05_RS05850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FPL05_RS05860	COG1063	alcohol dehydrogenase
FPL05_RS05890	COG0406	alpha-ribazole phosphatase activity
FPL05_RS05895	COG0285	dihydrofolate synthase activity
FPL05_RS05915	COG2833	Protein of unknown function (DUF455)
FPL05_RS05935	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL05_RS05940	COG0671	phosphoesterase, PA-phosphatase related
FPL05_RS05945	COG0438	transferase activity, transferring glycosyl groups
FPL05_RS05955	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FPL05_RS05970	COG4783	chaperone-mediated protein folding
FPL05_RS05985	COG0473	3-isopropylmalate dehydrogenase activity
FPL05_RS06165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL05_RS06165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL05_RS06475	COG4695	Portal protein
FPL05_RS06535	COG0544	peptidyl-prolyl cis-trans isomerase activity
FPL05_RS06545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FPL05_RS06575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL05_RS06585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL05_RS06595	COG0328	RNA-DNA hybrid ribonuclease activity
FPL05_RS06600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FPL05_RS06605	COG0631	protein serine/threonine phosphatase activity
FPL05_RS06620	COG0859	PFAM glycosyl transferase family 9
FPL05_RS06625	COG3642	lipopolysaccharide core region biosynthetic process
FPL05_RS06630	COG1234	tRNA 3'-trailer cleavage
FPL05_RS06635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FPL05_RS06645	COG0315	cyclic pyranopterin monophosphate synthase activity
FPL05_RS06650	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FPL05_RS06655	COG0314	molybdopterin synthase activity
FPL05_RS06675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FPL05_RS06680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FPL05_RS06685	COG0537	adenosine 5'-monophosphoramidase activity
FPL05_RS06705	COG0714	Associated with various cellular activities
FPL05_RS06725	COG0424	maF-like protein
FPL05_RS06730	COG1399	metal-binding, possibly nucleic acid-binding protein
FPL05_RS06735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FPL05_RS06740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL05_RS06755	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS06770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FPL05_RS06775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FPL05_RS06820	COG3829	transcription factor binding
FPL05_RS06840	COG3609	addiction module antidote protein, CC2985 family
FPL05_RS06875	COG2373	Large extracellular alpha-helical protein
FPL05_RS06895	COG4953	penicillin-binding protein 1C
FPL05_RS06905	COG0678	peroxiredoxin activity
FPL05_RS06925	COG0330	HflC and HflK could
FPL05_RS06930	COG0330	HflC and HflK could
FPL05_RS06940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FPL05_RS06945	COG0308	aminopeptidase N
FPL05_RS06950	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS06955	COG1309	transcriptional regulator
FPL05_RS06985	COG0732	type I restriction modification DNA specificity domain
FPL05_RS07020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FPL05_RS07030	COG3387	PFAM Glycoside hydrolase 15-related
FPL05_RS07035	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS07045	COG3537	Alpha-1,2-mannosidase
FPL05_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS07070	COG0492	ferredoxin-NADP+ reductase activity
FPL05_RS07095	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FPL05_RS07100	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FPL05_RS07105	COG2080	2 iron, 2 sulfur cluster binding
FPL05_RS07140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL05_RS07155	COG0587	DNA-directed DNA polymerase activity
FPL05_RS07175	COG1297	OPT oligopeptide transporter protein
FPL05_RS07190	COG1506	peptidase
FPL05_RS07190	COG0823	Involved in the tonB-independent uptake of proteins
FPL05_RS07210	COG2207	Transcriptional regulator
FPL05_RS07210	COG1917	Cupin 2, conserved barrel domain protein
FPL05_RS07230	COG0753	catalase activity
FPL05_RS07235	COG0656	L-ascorbic acid biosynthetic process
FPL05_RS07245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FPL05_RS07245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FPL05_RS07250	COG2814	Major facilitator Superfamily
FPL05_RS07265	COG2194	sulfuric ester hydrolase activity
FPL05_RS07280	COG0745	RESPONSE REGULATOR receiver
FPL05_RS07285	COG0642	Histidine kinase
FPL05_RS07295	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FPL05_RS07300	COG2894	cell division
FPL05_RS07305	COG0850	regulation of cytokinetic process
FPL05_RS07320	COG4585	Histidine kinase
FPL05_RS07325	COG2197	response regulator
FPL05_RS07340	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FPL05_RS07375	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FPL05_RS07385	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FPL05_RS07405	COG1946	Acyl-CoA thioesterase
FPL05_RS07420	COG0824	Thioesterase
FPL05_RS07425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FPL05_RS07430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FPL05_RS07435	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FPL05_RS07440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FPL05_RS07445	COG0268	Binds directly to 16S ribosomal RNA
FPL05_RS07455	COG0196	riboflavin kinase activity
FPL05_RS07460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FPL05_RS07465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FPL05_RS07470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FPL05_RS07485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FPL05_RS07490	COG1845	cytochrome c oxidase, subunit III
FPL05_RS07495	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FPL05_RS07510	COG3152	Membrane
FPL05_RS07520	COG2207	Transcriptional regulator
FPL05_RS07525	COG0326	Molecular chaperone. Has ATPase activity
FPL05_RS07540	COG1366	Belongs to the anti-sigma-factor antagonist family
FPL05_RS07545	COG1366	Belongs to the anti-sigma-factor antagonist family
FPL05_RS07550	COG2172	sigma factor antagonist activity
FPL05_RS07575	COG4771	TonB-dependent receptor
FPL05_RS07585	COG5507	3-demethylubiquinone-9 3-methyltransferase
FPL05_RS07590	COG2205	protein histidine kinase activity
FPL05_RS07600	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FPL05_RS07605	COG4999	Histidine kinase
FPL05_RS07605	COG3437	response regulator, receiver
FPL05_RS07605	COG2205	protein histidine kinase activity
FPL05_RS07605	COG3850	Histidine kinase
FPL05_RS07610	COG4191	Histidine kinase
FPL05_RS07610	COG0784	Response regulator, receiver
FPL05_RS07635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FPL05_RS07640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FPL05_RS07650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FPL05_RS07655	COG0228	four-way junction DNA binding
FPL05_RS07660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FPL05_RS07665	COG0336	Belongs to the RNA methyltransferase TrmD family
FPL05_RS07670	COG0335	large ribosomal subunit rRNA binding
FPL05_RS07675	COG0534	Mate efflux family protein
FPL05_RS07695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FPL05_RS07705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FPL05_RS07730	COG2963	transposase activity
FPL05_RS07745	COG3250	beta-galactosidase activity
FPL05_RS07750	COG3867	Arabinogalactan endo-beta-1,4-galactanase
FPL05_RS07770	COG1960	acyl-CoA dehydrogenase activity
FPL05_RS07775	COG1024	Enoyl-CoA hydratase
FPL05_RS07810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FPL05_RS07815	COG0481	GTPase activity
FPL05_RS07830	COG0571	ribonuclease III activity
FPL05_RS07835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FPL05_RS07840	COG1381	Involved in DNA repair and RecF pathway recombination
FPL05_RS07850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FPL05_RS07860	COG2954	triphosphatase activity
FPL05_RS07865	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FPL05_RS07870	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FPL05_RS07875	COG3046	protein related to deoxyribodipyrimidine photolyase
FPL05_RS07880	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL05_RS07885	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FPL05_RS07890	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FPL05_RS07895	COG1278	Cold shock
FPL05_RS07915	COG1201	RNA secondary structure unwinding
FPL05_RS07920	COG1793	dna ligase
FPL05_RS07930	COG1793	dna ligase
FPL05_RS07930	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FPL05_RS07960	COG0183	Belongs to the thiolase family
FPL05_RS07985	COG1451	nucleotide metabolic process
FPL05_RS07990	COG5487	UPF0391 membrane protein
FPL05_RS08000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FPL05_RS08015	COG1077	Cell shape determining protein MreB Mrl
FPL05_RS08020	COG1047	Peptidyl-prolyl cis-trans
FPL05_RS08030	COG2824	Alkylphosphonate utilization operon protein PhnA
FPL05_RS08040	COG1902	pentaerythritol trinitrate reductase activity
FPL05_RS08045	COG2814	Major facilitator Superfamily
FPL05_RS08080	COG0392	lysyltransferase activity
FPL05_RS08080	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FPL05_RS08090	COG0251	oxidation-reduction process
FPL05_RS08095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FPL05_RS08110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FPL05_RS08135	COG1595	DNA-templated transcription, initiation
FPL05_RS08155	COG2878	Part of a membrane complex involved in electron transport
FPL05_RS08165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL05_RS08165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL05_RS08180	COG1131	(ABC) transporter
FPL05_RS08185	COG0346	lactoylglutathione lyase activity
FPL05_RS08190	COG0833	amino acid
FPL05_RS08195	COG2040	homocysteine
FPL05_RS08205	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FPL05_RS08225	COG1695	Transcriptional regulator
FPL05_RS08245	COG1981	membrane
FPL05_RS08260	COG0825	malonyl-CoA metabolic process
FPL05_RS08270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FPL05_RS08275	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL05_RS08280	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL05_RS08285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPL05_RS08290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL05_RS08305	COG0750	zinc metalloprotease
FPL05_RS08310	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FPL05_RS08315	COG0575	Belongs to the CDS family
FPL05_RS08320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FPL05_RS08325	COG0233	cytoplasmic translational termination
FPL05_RS08330	COG0528	UMP kinase activity
FPL05_RS08340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FPL05_RS08345	COG0052	Belongs to the universal ribosomal protein uS2 family
FPL05_RS08385	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FPL05_RS08395	COG1393	Belongs to the ArsC family
FPL05_RS08400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FPL05_RS08405	COG0367	asparagine synthase
FPL05_RS08415	COG4774	siderophore transport
FPL05_RS08430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FPL05_RS08465	COG1566	PFAM secretion protein HlyD family protein
FPL05_RS08470	COG2814	Major facilitator Superfamily
FPL05_RS08520	COG0339	signal peptide processing
FPL05_RS08530	COG0386	Belongs to the glutathione peroxidase family
FPL05_RS08585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FPL05_RS08590	COG0084	hydrolase, TatD family'
FPL05_RS08605	COG1960	acyl-CoA dehydrogenase activity
FPL05_RS08625	COG0367	asparagine synthase
FPL05_RS08635	COG0305	Participates in initiation and elongation during chromosome replication
FPL05_RS08640	COG0415	Belongs to the DNA photolyase family
FPL05_RS08660	COG0583	DNA-binding transcription factor activity
FPL05_RS08705	COG3706	GGDEF domain
FPL05_RS08740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FPL05_RS08755	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL05_RS08765	COG0497	DNA recombination
FPL05_RS08770	COG1420	regulation of RNA biosynthetic process
FPL05_RS08775	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FPL05_RS08780	COG0443	Heat shock 70 kDa protein
FPL05_RS08785	COG0484	heat shock protein binding
FPL05_RS08825	COG0583	DNA-binding transcription factor activity
FPL05_RS08830	COG1132	(ABC) transporter
FPL05_RS08865	COG2850	peptidyl-arginine hydroxylation
FPL05_RS08885	COG1253	flavin adenine dinucleotide binding
FPL05_RS08915	COG1131	(ABC) transporter
FPL05_RS08920	COG1725	Transcriptional regulator
FPL05_RS08930	COG0386	Belongs to the glutathione peroxidase family
FPL05_RS08945	COG2900	Belongs to the SlyX family
FPL05_RS08970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPL05_RS08980	COG0646	methionine synthase
FPL05_RS08980	COG1410	methionine synthase
FPL05_RS08985	COG1410	methionine synthase
FPL05_RS08985	COG0646	methionine synthase
FPL05_RS08990	COG2226	methyltransferase
FPL05_RS08995	COG1960	acyl-CoA dehydrogenase activity
FPL05_RS09000	COG1960	acyl-CoA dehydrogenase activity
FPL05_RS09005	COG1960	acyl-CoA dehydrogenase activity
FPL05_RS09010	COG1960	acyl-CoA dehydrogenase activity
FPL05_RS09015	COG1960	acyl-CoA dehydrogenase activity
FPL05_RS09035	COG0557	exoribonuclease II activity
FPL05_RS09045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPL05_RS09055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FPL05_RS09065	COG0704	Plays a role in the regulation of phosphate uptake
FPL05_RS09070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FPL05_RS09075	COG0581	inorganic phosphate transmembrane transporter activity
FPL05_RS09080	COG0573	inorganic phosphate transmembrane transporter activity
FPL05_RS09085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FPL05_RS09110	COG0659	secondary active sulfate transmembrane transporter activity
FPL05_RS09115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FPL05_RS09125	COG1024	Enoyl-CoA hydratase
FPL05_RS09135	COG0494	nUDIX hydrolase
FPL05_RS09170	COG0488	(ABC) transporter
FPL05_RS09180	COG0116	Belongs to the methyltransferase superfamily
FPL05_RS09180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FPL05_RS09185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FPL05_RS09210	COG2925	Exonuclease
FPL05_RS09220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL05_RS09225	COG3844	kynureninase activity
FPL05_RS09235	COG0662	Cupin 2, conserved barrel domain protein
FPL05_RS09240	COG0288	reversible hydration of carbon dioxide
FPL05_RS09305	COG2808	Putative FMN-binding domain
FPL05_RS09325	COG0017	Asparaginyl-tRNA synthetase
FPL05_RS09335	COG0316	Belongs to the HesB IscA family
FPL05_RS09340	COG0360	Binds together with S18 to 16S ribosomal RNA
FPL05_RS09345	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FPL05_RS09350	COG0359	binds to the 23S rRNA
FPL05_RS09360	COG3115	cell septum assembly
FPL05_RS09370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL05_RS09375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FPL05_RS09380	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FPL05_RS09395	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FPL05_RS09405	COG4993	Dehydrogenase
FPL05_RS09420	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FPL05_RS09430	COG2986	histidine ammonia-lyase
FPL05_RS09435	COG1228	amidohydrolase
FPL05_RS09480	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FPL05_RS09485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FPL05_RS09490	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FPL05_RS09495	COG0077	Prephenate dehydratase
FPL05_RS09495	COG1605	Chorismate mutase
FPL05_RS09500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FPL05_RS09515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FPL05_RS09520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FPL05_RS09525	COG0583	DNA-binding transcription factor activity
FPL05_RS09540	COG0840	transmembrane signaling receptor activity
FPL05_RS09575	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FPL05_RS09580	COG4191	Histidine kinase
FPL05_RS09580	COG0784	Response regulator, receiver
FPL05_RS09595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL05_RS09605	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FPL05_RS09615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FPL05_RS09630	COG1595	DNA-templated transcription, initiation
FPL05_RS09685	COG2244	polysaccharide biosynthetic process
FPL05_RS09715	COG2264	protein methyltransferase activity
FPL05_RS09740	COG1136	(ABC) transporter
FPL05_RS09750	COG0477	Major facilitator Superfamily
FPL05_RS09755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL05_RS09770	COG1253	flavin adenine dinucleotide binding
FPL05_RS09785	COG0306	phosphate transporter
FPL05_RS09810	COG0504	CTP synthase activity
FPL05_RS09815	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FPL05_RS09825	COG0148	phosphopyruvate hydratase activity
FPL05_RS09830	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FPL05_RS09835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FPL05_RS09840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FPL05_RS09845	COG0585	pseudouridine synthase activity
FPL05_RS09850	COG2840	Smr protein MutS2
FPL05_RS09855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FPL05_RS09860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FPL05_RS09865	COG1238	metal cluster binding
FPL05_RS09885	COG1534	Rna-binding protein
FPL05_RS09890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FPL05_RS09900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FPL05_RS09905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FPL05_RS09915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FPL05_RS09920	COG1546	Belongs to the CinA family
FPL05_RS09930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL05_RS09935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FPL05_RS09945	COG2137	regulation of response to DNA damage stimulus
FPL05_RS09950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FPL05_RS09955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FPL05_RS09975	COG1741	Belongs to the pirin family
FPL05_RS09980	COG0583	DNA-binding transcription factor activity
FPL05_RS10005	COG0351	phosphomethylpyrimidine kinase
FPL05_RS10020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FPL05_RS10025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FPL05_RS10040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPL05_RS10050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FPL05_RS10055	COG3734	2-keto-3-deoxy-galactonokinase
FPL05_RS10065	COG4948	Mandelate Racemase Muconate Lactonizing
FPL05_RS10070	COG0800	Aldolase
FPL05_RS10110	COG1501	Belongs to the glycosyl hydrolase 31 family
FPL05_RS10120	COG1070	Carbohydrate kinase
FPL05_RS10125	COG2115	Belongs to the xylose isomerase family
FPL05_RS10130	COG0477	Major facilitator Superfamily
FPL05_RS10150	COG0860	N-Acetylmuramoyl-L-alanine amidase
FPL05_RS10155	COG1469	GTP cyclohydrolase I activity
FPL05_RS10175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FPL05_RS10180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FPL05_RS10185	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FPL05_RS10190	COG0166	Belongs to the GPI family
FPL05_RS10215	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL05_RS10230	COG2203	Gaf domain
FPL05_RS10230	COG5001	Diguanylate cyclase
FPL05_RS10230	COG3706	GGDEF domain
FPL05_RS10230	COG4251	negative regulation of phosphorylation
FPL05_RS10235	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL05_RS10240	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FPL05_RS10250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FPL05_RS10255	COG0671	phosphoesterase, PA-phosphatase related
FPL05_RS10270	COG1794	racemase activity, acting on amino acids and derivatives
FPL05_RS10280	COG0697	spore germination
FPL05_RS10285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FPL05_RS10290	COG0167	dihydroorotate dehydrogenase activity
FPL05_RS10310	COG1012	belongs to the aldehyde dehydrogenase family
FPL05_RS10370	COG2003	Belongs to the UPF0758 family
FPL05_RS10445	COG0758	DNA mediated transformation
FPL05_RS10545	COG2814	Major facilitator Superfamily
FPL05_RS10610	COG3621	Patatin-like phospholipase
FPL05_RS10660	COG1215	transferase activity, transferring glycosyl groups
FPL05_RS10665	COG1649	PFAM Uncharacterised BCR, COG1649
FPL05_RS10665	COG0726	polysaccharide deacetylase
FPL05_RS10755	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FPL05_RS10790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL05_RS10795	COG0124	histidyl-tRNA synthetase
FPL05_RS10805	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FPL05_RS10810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FPL05_RS10815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL05_RS10820	COG0131	Imidazoleglycerol-phosphate dehydratase
FPL05_RS10820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FPL05_RS10825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FPL05_RS10830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FPL05_RS10835	COG0107	imidazoleglycerol-phosphate synthase activity
FPL05_RS10840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FPL05_RS10840	COG0140	phosphoribosyl-ATP diphosphatase activity
FPL05_RS10855	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FPL05_RS10860	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FPL05_RS10865	COG0235	Class ii aldolase
FPL05_RS10870	COG0531	amino acid
FPL05_RS10875	COG0531	amino acid
FPL05_RS10885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FPL05_RS10890	COG0277	FAD linked oxidase domain protein
FPL05_RS10910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FPL05_RS10955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL05_RS10960	COG2258	MOSC domain
FPL05_RS10965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FPL05_RS10970	COG0505	Belongs to the CarA family
FPL05_RS10980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FPL05_RS10985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL05_RS10995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FPL05_RS11005	COG3279	Response regulator of the LytR AlgR family
FPL05_RS11015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FPL05_RS11025	COG2198	Histidine kinase
FPL05_RS11025	COG0784	Response regulator, receiver
FPL05_RS11025	COG2205	protein histidine kinase activity
FPL05_RS11030	COG2205	protein histidine kinase activity
FPL05_RS11030	COG2198	Histidine kinase
FPL05_RS11030	COG0784	Response regulator, receiver
FPL05_RS11035	COG1024	Enoyl-CoA hydratase
FPL05_RS11040	COG0318	PFAM AMP-dependent synthetase and ligase
FPL05_RS11070	COG2267	carboxylic ester hydrolase activity
FPL05_RS11080	COG2201	protein-glutamate methylesterase activity
FPL05_RS11085	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FPL05_RS11095	COG0840	transmembrane signaling receptor activity
FPL05_RS11105	COG0835	chemotaxis
FPL05_RS11120	COG0840	transmembrane signaling receptor activity
FPL05_RS11125	COG0840	transmembrane signaling receptor activity
FPL05_RS11130	COG0840	transmembrane signaling receptor activity
FPL05_RS11140	COG0840	transmembrane signaling receptor activity
FPL05_RS11150	COG0840	transmembrane signaling receptor activity
FPL05_RS11155	COG0840	transmembrane signaling receptor activity
FPL05_RS11160	COG0840	transmembrane signaling receptor activity
FPL05_RS11165	COG0840	transmembrane signaling receptor activity
FPL05_RS11180	COG0840	transmembrane signaling receptor activity
FPL05_RS11200	COG2198	Histidine kinase
FPL05_RS11200	COG0643	Histidine kinase
FPL05_RS11205	COG0745	RESPONSE REGULATOR receiver
FPL05_RS11215	COG0835	chemotaxis
FPL05_RS11225	COG1360	Flagellar Motor Protein
FPL05_RS11230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FPL05_RS11330	COG0641	radical SAM
FPL05_RS11345	COG2198	Histidine kinase
FPL05_RS11345	COG0784	Response regulator, receiver
FPL05_RS11345	COG0643	Histidine kinase
FPL05_RS11375	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FPL05_RS11405	COG1684	flagellar biosynthetic protein fliR
FPL05_RS11420	COG3190	flagellar
FPL05_RS11470	COG1677	Flagellar hook-basal body complex protein FliE
FPL05_RS11505	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS11510	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS11515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL05_RS11535	COG2201	protein-glutamate methylesterase activity
FPL05_RS11565	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FPL05_RS11570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FPL05_RS11575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FPL05_RS11585	COG3951	Flagellar rod assembly protein muramidase FlgJ
FPL05_RS11585	COG1705	Flagellar rod assembly protein muramidase FlgJ
FPL05_RS11590	COG1706	bacterial-type flagellum-dependent cell motility
FPL05_RS11595	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FPL05_RS11610	COG4787	bacterial-type flagellum-dependent cell motility
FPL05_RS11620	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FPL05_RS11625	COG1558	bacterial-type flagellum-dependent cell motility
FPL05_RS11635	COG0835	chemotaxis
FPL05_RS11635	COG0784	Response regulator, receiver
FPL05_RS11655	COG5002	protein histidine kinase activity
FPL05_RS11685	COG2915	High frequency lysogenization protein hflD homolog
FPL05_RS11690	COG0482	sulfurtransferase activity
FPL05_RS11705	COG0542	response to heat
FPL05_RS11715	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FPL05_RS11725	COG0492	ferredoxin-NADP+ reductase activity
FPL05_RS11730	COG1674	ftsk spoiiie
FPL05_RS11740	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FPL05_RS11750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FPL05_RS11755	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FPL05_RS11765	COG0183	Belongs to the thiolase family
FPL05_RS11770	COG1250	3-hydroxyacyl-CoA dehydrogenase
FPL05_RS11770	COG1024	Enoyl-CoA hydratase
FPL05_RS11785	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FPL05_RS11795	COG1426	Protein conserved in bacteria
FPL05_RS11805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL05_RS11810	COG1160	GTP binding
FPL05_RS11815	COG0303	'Molybdopterin
FPL05_RS11820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FPL05_RS11860	COG0708	Exodeoxyribonuclease III
FPL05_RS11870	COG0303	'Molybdopterin
FPL05_RS11875	COG0746	molybdenum cofactor guanylyltransferase activity
FPL05_RS11885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FPL05_RS11885	COG1648	precorrin-2 dehydrogenase activity
FPL05_RS11915	COG3685	Protein conserved in bacteria
FPL05_RS11935	COG5001	Diguanylate cyclase
FPL05_RS11945	COG4566	intracellular signal transduction
FPL05_RS11985	COG3275	phosphorelay sensor kinase activity
FPL05_RS11990	COG3279	Response regulator of the LytR AlgR family
FPL05_RS12025	COG1238	metal cluster binding
FPL05_RS12065	COG0653	protein targeting
FPL05_RS12080	COG0653	protein targeting
FPL05_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS12095	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FPL05_RS12100	COG2226	methyltransferase
FPL05_RS12100	COG1073	alpha beta
FPL05_RS12150	COG0316	Belongs to the HesB IscA family
FPL05_RS12150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FPL05_RS12155	COG2154	pterin-4-alpha-carbinolamine dehydratase
FPL05_RS12165	COG0428	transporter
FPL05_RS12170	COG3064	Membrane
FPL05_RS12180	COG1530	ribonuclease E activity
FPL05_RS12190	COG1054	Belongs to the UPF0176 family
FPL05_RS12210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FPL05_RS12250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FPL05_RS12255	COG0322	excinuclease ABC activity
FPL05_RS12265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FPL05_RS12270	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FPL05_RS12275	COG1663	tetraacyldisaccharide 4'-kinase activity
FPL05_RS12280	COG1132	(ABC) transporter
FPL05_RS12290	COG0811	peptide transport
FPL05_RS12305	COG1136	(ABC) transporter
FPL05_RS12310	COG4591	ABC-type transport system involved in lipoprotein release permease component
FPL05_RS12320	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FPL05_RS12325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FPL05_RS12340	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FPL05_RS12365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FPL05_RS12370	COG0837	glucose binding
FPL05_RS12375	COG0363	glucosamine-6-phosphate deaminase activity
FPL05_RS12380	COG0129	dihydroxy-acid dehydratase activity
FPL05_RS12385	COG0800	Aldolase
FPL05_RS12465	COG2183	response to ionizing radiation
FPL05_RS12475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL05_RS12475	COG0723	plastoquinol--plastocyanin reductase activity
FPL05_RS12490	COG3243	poly(R)-hydroxyalkanoic acid synthase
FPL05_RS12500	COG1183	phosphatidylcholine synthase activity
FPL05_RS12505	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS12520	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FPL05_RS12535	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FPL05_RS12550	COG1914	H( )-stimulated, divalent metal cation uptake system
FPL05_RS12570	COG2814	Major facilitator Superfamily
FPL05_RS12585	COG1335	isochorismatase
FPL05_RS12600	COG2197	response regulator
FPL05_RS12620	COG0583	DNA-binding transcription factor activity
FPL05_RS12625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FPL05_RS12630	COG3002	Belongs to the UPF0753 family
FPL05_RS12635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FPL05_RS12635	COG0519	Catalyzes the synthesis of GMP from XMP
FPL05_RS12645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FPL05_RS12655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPL05_RS12655	COG0475	glutathione-regulated potassium exporter activity
FPL05_RS12665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FPL05_RS12675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FPL05_RS12680	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FPL05_RS12690	COG0776	regulation of translation
FPL05_RS12695	COG0539	negative regulation of cytoplasmic translation
FPL05_RS12700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FPL05_RS12720	COG2957	Belongs to the agmatine deiminase family
FPL05_RS12725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPL05_RS12750	COG0395	ABC-type sugar transport system, permease component
FPL05_RS12755	COG1175	transmembrane transport
FPL05_RS12785	COG2350	Protein conserved in bacteria
FPL05_RS12790	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FPL05_RS12795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FPL05_RS12800	COG1187	pseudouridine synthase activity
FPL05_RS12820	COG0436	Aminotransferase
FPL05_RS12825	COG4133	protoheme IX ABC transporter activity
FPL05_RS12845	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FPL05_RS12850	COG1138	Cytochrome C-type biogenesis protein
FPL05_RS12870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL05_RS12875	COG1278	Cold shock
FPL05_RS12880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FPL05_RS12885	COG4988	ABC transporter
FPL05_RS12895	COG1294	oxidase, subunit
FPL05_RS12925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FPL05_RS12940	COG0165	Argininosuccinate lyase
FPL05_RS12945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FPL05_RS12955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FPL05_RS12960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FPL05_RS12970	COG0137	argininosuccinate synthase activity
FPL05_RS12975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FPL05_RS12985	COG0215	cysteine-tRNA ligase activity
FPL05_RS12990	COG2166	iron-sulfur cluster assembly
FPL05_RS13005	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FPL05_RS13010	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FPL05_RS13040	COG4302	ethanolamine ammonia-lyase activity
FPL05_RS13105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FPL05_RS13110	COG0402	S-adenosylhomocysteine deaminase activity
FPL05_RS13120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FPL05_RS13125	COG1509	lysine 2,3-aminomutase activity
FPL05_RS13130	COG5001	Diguanylate cyclase
FPL05_RS13130	COG3300	MHYT domain
FPL05_RS13145	COG0483	inositol monophosphate 1-phosphatase activity
FPL05_RS13150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FPL05_RS13170	COG0488	(ABC) transporter
FPL05_RS13175	COG0513	Belongs to the DEAD box helicase family
FPL05_RS13180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FPL05_RS13185	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FPL05_RS13195	COG0625	glutathione transferase activity
FPL05_RS13205	COG4681	YaeQ
FPL05_RS13210	COG2081	HI0933 family
FPL05_RS13220	COG0501	Belongs to the peptidase M48B family
FPL05_RS13225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL05_RS13230	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS13255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FPL05_RS13260	COG0860	N-Acetylmuramoyl-L-alanine amidase
FPL05_RS13265	COG0802	atpase or kinase
FPL05_RS13270	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FPL05_RS13270	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FPL05_RS13275	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FPL05_RS13280	COG1570	exodeoxyribonuclease VII activity
FPL05_RS13290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FPL05_RS13335	COG0835	chemotaxis
FPL05_RS13340	COG0840	transmembrane signaling receptor activity
FPL05_RS13345	COG2094	Belongs to the DNA glycosylase MPG family
FPL05_RS13350	COG1201	RNA secondary structure unwinding
FPL05_RS13370	COG2969	positive regulation of protein catabolic process
FPL05_RS13375	COG0625	glutathione transferase activity
FPL05_RS13380	COG2857	Cytochrome c1
FPL05_RS13385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FPL05_RS13390	COG0723	plastoquinol--plastocyanin reductase activity
FPL05_RS13400	COG0741	lytic transglycosylase activity
FPL05_RS13415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FPL05_RS13425	COG1702	phosphate starvation-inducible protein PhoH
FPL05_RS13435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FPL05_RS13445	COG4535	Mg2 and Co2 transporter CorC
FPL05_RS13460	COG1012	belongs to the aldehyde dehydrogenase family
FPL05_RS13465	COG1177	transmembrane transport
FPL05_RS13470	COG1176	ABC-type spermidine putrescine transport system, permease component I
FPL05_RS13495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FPL05_RS13515	COG0174	glutamine synthetase
FPL05_RS13520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL05_RS13530	COG2703	oxygen carrier activity
FPL05_RS13535	COG0477	Major facilitator Superfamily
FPL05_RS13550	COG0243	molybdopterin cofactor binding
FPL05_RS13555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FPL05_RS13560	COG2223	nitrite transmembrane transporter activity
FPL05_RS13575	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FPL05_RS13585	COG2733	membrane
FPL05_RS13590	COG5002	protein histidine kinase activity
FPL05_RS13590	COG2205	protein histidine kinase activity
FPL05_RS13590	COG0784	Response regulator, receiver
FPL05_RS13625	COG2902	Dehydrogenase
FPL05_RS13635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL05_RS13640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL05_RS13645	COG1609	Transcriptional regulator
FPL05_RS13650	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL05_RS13650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FPL05_RS13655	COG1105	Belongs to the carbohydrate kinase PfkB family
FPL05_RS13660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FPL05_RS13660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FPL05_RS13680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FPL05_RS13690	COG1862	Preprotein translocase
FPL05_RS13695	COG0343	queuine tRNA-ribosyltransferase activity
FPL05_RS13700	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FPL05_RS13740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FPL05_RS13745	COG3291	Pkd domain containing protein
FPL05_RS13750	COG0405	Gamma-glutamyltransferase
FPL05_RS13755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FPL05_RS13770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FPL05_RS13775	COG0742	ribosomal rna small subunit methyltransferase
FPL05_RS13780	COG0326	Molecular chaperone. Has ATPase activity
FPL05_RS13910	COG0531	amino acid
FPL05_RS13925	COG0006	proline dipeptidase activity
FPL05_RS13935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPL05_RS13950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL05_RS13955	COG3938	Belongs to the proline racemase family
FPL05_RS13965	COG0552	protein localization to endoplasmic reticulum
FPL05_RS13975	COG1194	a g-specific adenine glycosylase
FPL05_RS13980	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FPL05_RS13985	COG4191	Histidine kinase
FPL05_RS13985	COG0784	Response regulator, receiver
FPL05_RS14000	COG0322	excinuclease ABC activity
FPL05_RS14015	COG3040	lipid binding
FPL05_RS14030	COG1960	acyl-CoA dehydrogenase activity
FPL05_RS14040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FPL05_RS14060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL05_RS14065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL05_RS14070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL05_RS14095	COG0438	transferase activity, transferring glycosyl groups
FPL05_RS14105	COG0438	transferase activity, transferring glycosyl groups
FPL05_RS14110	COG0438	transferase activity, transferring glycosyl groups
FPL05_RS14160	COG0072	phenylalanine-tRNA ligase activity
FPL05_RS14160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL05_RS14165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FPL05_RS14180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FPL05_RS14185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FPL05_RS14200	COG2211	Major facilitator Superfamily
FPL05_RS14210	COG1082	Xylose isomerase domain protein TIM barrel
FPL05_RS14225	COG0366	Alpha amylase catalytic
FPL05_RS14265	COG3702	type iv secretory pathway
FPL05_RS14285	COG2948	multi-organism process
FPL05_RS14305	COG3505	Type IV secretory pathway VirD4
FPL05_RS14320	COG0556	nucleotide-excision repair
FPL05_RS14355	COG4695	Portal protein
FPL05_RS14400	COG3179	chitinase
FPL05_RS14625	COG1611	Belongs to the LOG family
FPL05_RS14640	COG2095	MarC family integral membrane protein
FPL05_RS14650	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FPL05_RS14685	COG1185	polyribonucleotide nucleotidyltransferase activity
FPL05_RS14690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FPL05_RS14695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FPL05_RS14700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FPL05_RS14705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FPL05_RS14710	COG0195	Participates in both transcription termination and antitermination
FPL05_RS14715	COG0779	Required for maturation of 30S ribosomal subunits
FPL05_RS14725	COG1007	ATP synthesis coupled electron transport
FPL05_RS14750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL05_RS14755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FPL05_RS14765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FPL05_RS14770	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FPL05_RS14775	COG0649	NAD binding
FPL05_RS14780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL05_RS14785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL05_RS14790	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL05_RS14805	COG0149	triose-phosphate isomerase activity
FPL05_RS14810	COG0300	oxidoreductase activity
FPL05_RS14840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FPL05_RS14845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FPL05_RS14860	COG0133	tryptophan synthase activity
FPL05_RS14870	COG0135	phosphoribosylanthranilate isomerase activity
FPL05_RS14875	COG0101	tRNA pseudouridine synthase activity
FPL05_RS14895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FPL05_RS14900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FPL05_RS14905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FPL05_RS14910	COG2890	protein-(glutamine-N5) methyltransferase activity
FPL05_RS14920	COG0688	phosphatidylethanolamine metabolic process
FPL05_RS14935	COG0433	COG0433 Predicted ATPase
FPL05_RS14940	COG0494	nUDIX hydrolase
FPL05_RS14960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL05_RS14965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FPL05_RS14975	COG2336	PFAM SpoVT AbrB
FPL05_RS15015	COG0420	3'-5' exonuclease activity
FPL05_RS15055	COG0717	Belongs to the dCTP deaminase family
FPL05_RS15065	COG0489	protein tyrosine kinase activity
FPL05_RS15085	COG3590	peptidase
FPL05_RS15095	COG3590	peptidase
FPL05_RS15115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL05_RS15120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL05_RS15125	COG2311	Membrane
FPL05_RS15130	COG1047	Peptidyl-prolyl cis-trans
FPL05_RS15135	COG0791	NLP P60 protein
FPL05_RS15140	COG0791	NLP P60 protein
FPL05_RS15150	COG4106	trans-aconitate 2-methyltransferase activity
FPL05_RS15155	COG1301	dicarboxylic acid transport
FPL05_RS15160	COG1785	Belongs to the alkaline phosphatase family
FPL05_RS15170	COG0037	tRNA processing
FPL05_RS15175	COG1722	exodeoxyribonuclease VII activity
FPL05_RS15180	COG0142	geranyltranstransferase activity
FPL05_RS15185	COG4104	PAAR repeat-containing protein
FPL05_RS15195	COG0312	modulator of DNA gyrase
FPL05_RS15200	COG3028	Belongs to the UPF0307 family
FPL05_RS15205	COG0312	modulator of DNA gyrase
FPL05_RS15215	COG3164	Protein of unknown function
FPL05_RS15225	COG0424	maF-like protein
FPL05_RS15230	COG2968	Membrane
FPL05_RS15245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FPL05_RS15260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FPL05_RS15275	COG0495	leucyl-tRNA aminoacylation
FPL05_RS15285	COG3118	belongs to the thioredoxin family
FPL05_RS15310	COG2155	Conserved Protein
FPL05_RS15355	COG1132	(ABC) transporter
FPL05_RS15385	COG1538	Outer membrane efflux protein
FPL05_RS15390	COG0745	RESPONSE REGULATOR receiver
FPL05_RS15395	COG5002	protein histidine kinase activity
FPL05_RS15395	COG5000	phosphorelay sensor kinase activity
FPL05_RS15400	COG0475	glutathione-regulated potassium exporter activity
FPL05_RS15410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FPL05_RS15435	COG1187	pseudouridine synthase activity
FPL05_RS15440	COG5001	Diguanylate cyclase
FPL05_RS15440	COG5002	protein histidine kinase activity
FPL05_RS15550	COG2951	lytic endotransglycosylase activity
FPL05_RS15555	COG4644	lycopene metabolic process
FPL05_RS15570	COG2369	cell adhesion
FPL05_RS15620	COG0667	Aldo Keto reductase
FPL05_RS15625	COG2814	Major facilitator Superfamily
FPL05_RS15630	COG0583	DNA-binding transcription factor activity
FPL05_RS15635	COG2207	Transcriptional regulator
FPL05_RS15650	COG0667	Aldo Keto reductase
FPL05_RS15655	COG1309	transcriptional regulator
FPL05_RS15665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL05_RS15680	COG0735	belongs to the Fur family
FPL05_RS15685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL05_RS15710	COG4452	Inner membrane protein CreD
FPL05_RS15725	COG2205	protein histidine kinase activity
FPL05_RS15730	COG0745	RESPONSE REGULATOR receiver
FPL05_RS15735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FPL05_RS15750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FPL05_RS15760	COG2198	Histidine kinase
FPL05_RS15760	COG0643	Histidine kinase
FPL05_RS15765	COG0840	transmembrane signaling receptor activity
FPL05_RS15770	COG0835	chemotaxis
FPL05_RS15775	COG2202	Pas domain
FPL05_RS15775	COG2200	EAL domain
FPL05_RS15775	COG2199	diguanylate cyclase activity
FPL05_RS15780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FPL05_RS15785	COG2201	protein-glutamate methylesterase activity
FPL05_RS15790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL05_RS15795	COG3590	peptidase
FPL05_RS15805	COG0588	phosphoglycerate mutase activity
FPL05_RS15810	COG1515	deoxyribonuclease V activity
FPL05_RS15820	COG1741	Belongs to the pirin family
FPL05_RS15835	COG1741	Belongs to the pirin family
FPL05_RS15840	COG1966	Carbon starvation protein
FPL05_RS15845	COG2879	small protein
FPL05_RS15890	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FPL05_RS15895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FPL05_RS15900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FPL05_RS15905	COG2080	2 iron, 2 sulfur cluster binding
FPL05_RS15915	COG4251	negative regulation of phosphorylation
FPL05_RS15915	COG5001	Diguanylate cyclase
FPL05_RS15915	COG3706	GGDEF domain
FPL05_RS15915	COG2203	Gaf domain
FPL05_RS15920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FPL05_RS15925	COG0732	type I restriction modification DNA specificity domain
FPL05_RS15975	COG0629	single-stranded DNA binding
FPL05_RS15980	COG0142	geranyltranstransferase activity
FPL05_RS15990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FPL05_RS16005	COG0527	aspartate kinase activity
FPL05_RS16010	COG0384	phenazine biosynthesis protein PhzF
FPL05_RS16015	COG0384	phenazine biosynthesis protein PhzF
FPL05_RS16025	COG1764	response to oxidative stress
FPL05_RS16030	COG0540	Belongs to the ATCase OTCase family
FPL05_RS16035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FPL05_RS16040	COG1678	Uncharacterized ACR, COG1678
FPL05_RS16050	COG0519	Catalyzes the synthesis of GMP from XMP
FPL05_RS16075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FPL05_RS16090	COG0739	heme binding
FPL05_RS16110	COG0693	protein deglycase activity
FPL05_RS16120	COG1959	2 iron, 2 sulfur cluster binding
FPL05_RS16125	COG0719	Fe-S assembly protein
FPL05_RS16130	COG0396	ATPase activity
FPL05_RS16135	COG0719	Fe-S assembly protein
FPL05_RS16140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FPL05_RS16150	COG2146	nitrite reductase [NAD(P)H] activity
FPL05_RS16155	COG4774	siderophore transport
FPL05_RS16160	COG3128	pkhd-type hydroxylase
FPL05_RS16185	COG1477	protein flavinylation
FPL05_RS16190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FPL05_RS16205	COG1555	photosystem II stabilization
FPL05_RS16220	COG3178	'Phosphotransferase
FPL05_RS16225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FPL05_RS16235	COG0628	permease
FPL05_RS16245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FPL05_RS16255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FPL05_RS16280	COG0271	Belongs to the BolA IbaG family
FPL05_RS16290	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FPL05_RS16300	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FPL05_RS16305	COG1137	ATPase activity
FPL05_RS16320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL05_RS16325	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FPL05_RS16330	COG1660	Displays ATPase and GTPase activities
FPL05_RS16340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL05_RS16345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FPL05_RS16355	COG2239	Acts as a magnesium transporter
FPL05_RS16370	COG1294	oxidase, subunit
FPL05_RS16375	COG1271	oxidase subunit
FPL05_RS16385	COG1113	amino acid transport
FPL05_RS16415	COG2197	response regulator
FPL05_RS16420	COG0531	amino acid
FPL05_RS16450	COG1234	tRNA 3'-trailer cleavage
FPL05_RS16525	COG0754	glutathionylspermidine amidase activity
FPL05_RS16550	COG1842	Phage shock protein A
FPL05_RS16560	COG0259	pyridoxamine-phosphate oxidase activity
FPL05_RS16565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FPL05_RS16570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FPL05_RS16580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FPL05_RS16585	COG0477	Major facilitator Superfamily
FPL05_RS16605	COG2198	Histidine kinase
FPL05_RS16605	COG0784	Response regulator, receiver
FPL05_RS16605	COG2205	protein histidine kinase activity
FPL05_RS16610	COG2353	YceI-like domain
FPL05_RS16630	COG1760	l-serine dehydratase
FPL05_RS16645	COG0460	homoserine dehydrogenase
FPL05_RS16645	COG0527	aspartate kinase activity
FPL05_RS16650	COG0626	cystathionine gamma-synthase activity
FPL05_RS16655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL05_RS16660	COG0739	heme binding
FPL05_RS16665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FPL05_RS16670	COG1272	protein, Hemolysin III
FPL05_RS16675	COG2982	Protein involved in outer membrane biogenesis
FPL05_RS16680	COG0517	IMP dehydrogenase activity
FPL05_RS16680	COG0516	GMP reductase activity
FPL05_RS16685	COG0463	Glycosyl transferase, family 2
FPL05_RS16690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FPL05_RS16695	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FPL05_RS16705	COG4771	TonB-dependent receptor
FPL05_RS16710	COG1309	transcriptional regulator
FPL05_RS16720	COG1960	acyl-CoA dehydrogenase activity
FPL05_RS16750	COG0509	glycine decarboxylation via glycine cleavage system
FPL05_RS16755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FPL05_RS16780	COG1742	UPF0060 membrane protein
FPL05_RS16785	COG3956	TIGRFAM MazG family protein
FPL05_RS16795	COG0494	nUDIX hydrolase
FPL05_RS16805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FPL05_RS16810	COG0837	glucose binding
FPL05_RS16825	COG1388	LysM domain
FPL05_RS16825	COG3858	chitin binding
FPL05_RS16840	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL05_RS16855	COG0531	amino acid
FPL05_RS16865	COG1486	melibiose metabolic process
FPL05_RS16875	COG3537	Alpha-1,2-mannosidase
FPL05_RS16915	COG3142	Participates in the control of copper homeostasis
FPL05_RS16920	COG1446	asparaginase
FPL05_RS16950	COG0643	Histidine kinase
FPL05_RS16950	COG2198	Histidine kinase
FPL05_RS16950	COG0784	Response regulator, receiver
FPL05_RS16955	COG0840	transmembrane signaling receptor activity
FPL05_RS16960	COG0835	chemotaxis
FPL05_RS16975	COG0189	ligase activity
FPL05_RS16985	COG1397	ADP-ribosylglycohydrolase
FPL05_RS16995	COG1199	ATP-dependent helicase activity
FPL05_RS17005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FPL05_RS17010	COG1215	transferase activity, transferring glycosyl groups
FPL05_RS17025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPL05_RS17035	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FPL05_RS17040	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FPL05_RS17045	COG0535	radical SAM domain protein
FPL05_RS17050	COG0535	radical SAM domain protein
FPL05_RS17065	COG0837	glucose binding
FPL05_RS17080	COG1643	Atp-dependent helicase
FPL05_RS17085	COG0783	Belongs to the Dps family
FPL05_RS17090	COG0514	ATP-dependent DNA helicase (RecQ)
FPL05_RS17125	COG0840	transmembrane signaling receptor activity
FPL05_RS17145	COG3920	Histidine kinase
FPL05_RS17150	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FPL05_RS17390	COG4695	Portal protein
FPL05_RS17430	COG0602	queuosine metabolic process
FPL05_RS17440	COG2885	chlorophyll binding
FPL05_RS17445	COG0823	Involved in the tonB-independent uptake of proteins
FPL05_RS17455	COG0848	biopolymer transport protein
FPL05_RS17465	COG0824	Thioesterase
FPL05_RS17470	COG2255	four-way junction helicase activity
FPL05_RS17480	COG3158	transport of potassium into the cell
FPL05_RS17485	COG0632	four-way junction helicase activity
FPL05_RS17490	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FPL05_RS17495	COG0217	transcriptional regulatory protein
FPL05_RS17510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FPL05_RS17650	COG2951	lytic endotransglycosylase activity
FPL05_RS17665	COG0477	Major facilitator Superfamily
FPL05_RS17705	COG0488	(ABC) transporter
FPL05_RS17745	COG4651	solute:proton antiporter activity
FPL05_RS17745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPL05_RS17770	COG4772	TonB-dependent receptor
FPL05_RS17780	COG4264	IucA IucC family
FPL05_RS17795	COG0019	diaminopimelate decarboxylase activity
FPL05_RS17815	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FPL05_RS17825	COG1492	cobalamin metabolic process
FPL05_RS17835	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FPL05_RS17860	COG4206	TonB-dependent receptor
FPL05_RS17865	COG0542	response to heat
FPL05_RS17870	COG1116	anion transmembrane transporter activity
FPL05_RS17875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL05_RS17880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FPL05_RS17885	COG0667	Aldo Keto reductase
FPL05_RS17890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL05_RS17895	COG4771	TonB-dependent receptor
FPL05_RS17905	COG2827	Endonuclease containing a URI domain
FPL05_RS17950	COG1877	trehalose-phosphatase activity
FPL05_RS17975	COG0840	transmembrane signaling receptor activity
FPL05_RS17980	COG3011	Protein conserved in bacteria
FPL05_RS17995	COG0564	pseudouridine synthase activity
FPL05_RS18000	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL05_RS18010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FPL05_RS18010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPL05_RS18020	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FPL05_RS18025	COG0045	succinate-CoA ligase (ADP-forming) activity
FPL05_RS18070	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FPL05_RS18075	COG0237	dephospho-CoA kinase activity
FPL05_RS18095	COG5002	protein histidine kinase activity
FPL05_RS18100	COG0745	RESPONSE REGULATOR receiver
FPL05_RS18110	COG0189	ligase activity
FPL05_RS18220	COG3657	addiction module killer protein
FPL05_RS18250	COG3209	COG3209 Rhs family protein
FPL05_RS18300	COG2022	thiamine diphosphate biosynthetic process
FPL05_RS18310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FPL05_RS18315	COG3273	potassium ion transport
FPL05_RS18315	COG0471	metal ion transport
FPL05_RS18380	COG0784	Response regulator, receiver
FPL05_RS18380	COG2205	protein histidine kinase activity
FPL05_RS18385	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FPL05_RS18400	COG5297	Belongs to the glycosyl hydrolase family 6
FPL05_RS18410	COG3250	beta-galactosidase activity
FPL05_RS18415	COG4948	Mandelate Racemase Muconate Lactonizing
FPL05_RS18430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPL05_RS18440	COG0308	aminopeptidase N
FPL05_RS18445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL05_RS18455	COG0529	Catalyzes the synthesis of activated sulfate
FPL05_RS18455	COG2895	sulfate adenylyltransferase (ATP) activity
FPL05_RS18460	COG0175	sulfate reduction
FPL05_RS18465	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FPL05_RS18470	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FPL05_RS18475	COG0175	sulfate reduction
FPL05_RS18495	COG2205	protein histidine kinase activity
FPL05_RS18495	COG0784	Response regulator, receiver
FPL05_RS18495	COG2198	Histidine kinase
FPL05_RS18515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FPL05_RS18515	COG1648	precorrin-2 dehydrogenase activity
FPL05_RS18530	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FPL05_RS18535	COG3588	fructose-bisphosphate aldolase
FPL05_RS18550	COG0469	pyruvate kinase activity
FPL05_RS18560	COG0126	phosphoglycerate kinase activity
FPL05_RS18585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FPL05_RS18595	COG3047	cAMP biosynthetic process
FPL05_RS18600	COG3047	cAMP biosynthetic process
FPL05_RS18610	COG3453	Protein conserved in bacteria
FPL05_RS18610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL05_RS18615	COG0725	ABC transporter, periplasmic molybdate-binding protein
FPL05_RS18620	COG4149	molybdate abc transporter
FPL05_RS18625	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FPL05_RS18660	COG1376	ErfK ybiS ycfS ynhG family protein
FPL05_RS18665	COG0739	heme binding
FPL05_RS18675	COG4773	Receptor
FPL05_RS18680	COG0596	Alpha beta hydrolase
FPL05_RS18685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FPL05_RS18690	COG1301	dicarboxylic acid transport
FPL05_RS18700	COG2304	oxidoreductase activity
FPL05_RS18720	COG0714	Associated with various cellular activities
FPL05_RS18750	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FPL05_RS18775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FPL05_RS18785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPL05_RS18795	COG0194	GDP metabolic process
FPL05_RS18800	COG1561	YicC-like family, N-terminal region
FPL05_RS18805	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FPL05_RS18815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FPL05_RS18820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FPL05_RS18835	COG0006	proline dipeptidase activity
FPL05_RS18845	COG0006	proline dipeptidase activity
FPL05_RS18850	COG3079	Belongs to the UPF0149 family
FPL05_RS18870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FPL05_RS18880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FPL05_RS18890	COG2912	Transglutaminase-like superfamily
FPL05_RS18895	COG1773	rubredoxin
FPL05_RS18900	COG0352	thiamine-phosphate diphosphorylase activity
FPL05_RS18910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FPL05_RS18930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL05_RS18960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FPL05_RS18965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL05_RS18975	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS18985	COG0671	phosphoesterase, PA-phosphatase related
FPL05_RS18990	COG3781	membrane
FPL05_RS19000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPL05_RS19005	COG0563	adenylate kinase activity
FPL05_RS19030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FPL05_RS19055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FPL05_RS19070	COG0840	transmembrane signaling receptor activity
FPL05_RS19075	COG0405	Gamma-glutamyltransferase
FPL05_RS19080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FPL05_RS19100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FPL05_RS19110	COG0473	3-isopropylmalate dehydrogenase activity
FPL05_RS19115	COG0066	3-isopropylmalate dehydratase activity
FPL05_RS19120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FPL05_RS19140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FPL05_RS19145	COG1538	Outer membrane efflux protein
FPL05_RS19150	COG1519	Transferase
FPL05_RS19160	COG1560	Kdo2-lipid A biosynthetic process
FPL05_RS19190	COG0280	phosphate acetyltransferase
FPL05_RS19190	COG0281	malic enzyme
FPL05_RS19195	COG1301	dicarboxylic acid transport
FPL05_RS19220	COG0583	DNA-binding transcription factor activity
FPL05_RS19225	COG0667	Aldo Keto reductase
FPL05_RS19240	COG2197	response regulator
FPL05_RS19250	COG0642	Histidine kinase
FPL05_RS19270	COG2851	Citrate transporter
FPL05_RS19275	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS19285	COG2211	Major facilitator Superfamily
FPL05_RS19310	COG1162	GTPase activity
FPL05_RS19345	COG4773	Receptor
FPL05_RS19350	COG0726	polysaccharide deacetylase
FPL05_RS19355	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FPL05_RS19370	COG3964	amidohydrolase
FPL05_RS19375	COG0402	S-adenosylhomocysteine deaminase activity
FPL05_RS19400	COG1307	EDD domain protein, DegV family
FPL05_RS19405	COG0242	peptide deformylase activity
FPL05_RS19440	COG0457	Tetratricopeptide repeat
FPL05_RS19445	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FPL05_RS19450	COG1215	transferase activity, transferring glycosyl groups
FPL05_RS19455	COG1215	transferase activity, transferring glycosyl groups
FPL05_RS19470	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FPL05_RS19525	COG2188	Transcriptional regulator
FPL05_RS19545	COG1450	Type ii and iii secretion system protein
FPL05_RS19560	COG3166	PFAM Fimbrial assembly family protein
FPL05_RS19565	COG3156	type II secretion system protein K
FPL05_RS19570	COG4795	General secretion pathway protein
FPL05_RS19575	COG2165	general secretion pathway protein
FPL05_RS19580	COG4970	Tfp pilus assembly protein FimT
FPL05_RS19585	COG2165	general secretion pathway protein
FPL05_RS19590	COG1459	type II secretion system
FPL05_RS19600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FPL05_RS19605	COG1404	Belongs to the peptidase S8 family
FPL05_RS19610	COG5295	Hep Hag repeat protein
FPL05_RS19615	COG1404	Belongs to the peptidase S8 family
FPL05_RS19620	COG5295	Hep Hag repeat protein
FPL05_RS19630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FPL05_RS19630	COG0047	phosphoribosylformylglycinamidine synthase activity
FPL05_RS19645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL05_RS19660	COG4974	Belongs to the 'phage' integrase family
FPL05_RS19675	COG0795	lipopolysaccharide-transporting ATPase activity
FPL05_RS19685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FPL05_RS19700	COG0525	valine-tRNA ligase activity
FPL05_RS19730	COG1183	phosphatidylcholine synthase activity
FPL05_RS19740	COG0442	prolyl-tRNA aminoacylation
FPL05_RS19755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPL05_RS19760	COG1127	ABC transporter
FPL05_RS19765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPL05_RS19765	COG3218	ABC-type transport auxiliary lipoprotein component
FPL05_RS19795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FPL05_RS19800	COG0662	Cupin 2, conserved barrel domain protein
FPL05_RS19800	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FPL05_RS19830	COG2086	electron transfer activity
FPL05_RS19845	COG0463	Glycosyl transferase, family 2
FPL05_RS19865	COG2813	Specifically methylates the guanine in position
FPL05_RS19880	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FPL05_RS19885	COG0438	transferase activity, transferring glycosyl groups
FPL05_RS19915	COG0626	cystathionine gamma-synthase activity
FPL05_RS19945	COG0625	glutathione transferase activity
FPL05_RS19960	COG0513	Belongs to the DEAD box helicase family
FPL05_RS19970	COG4206	TonB-dependent receptor
FPL05_RS19980	COG0720	synthase
FPL05_RS19990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FPL05_RS20000	COG1956	GAF domain-containing protein
FPL05_RS20010	COG2819	hydrolase of the alpha beta superfamily
FPL05_RS20020	COG0546	phosphoglycolate phosphatase activity
FPL05_RS20025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FPL05_RS20030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPL05_RS20045	COG0339	signal peptide processing
FPL05_RS20100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPL05_RS20105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL05_RS20110	COG4591	ABC-type transport system involved in lipoprotein release permease component
FPL05_RS20110	COG1136	(ABC) transporter
FPL05_RS20115	COG0577	efflux transmembrane transporter activity
FPL05_RS20135	COG4191	Histidine kinase
FPL05_RS20140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FPL05_RS20155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FPL05_RS20160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FPL05_RS20165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FPL05_RS20170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FPL05_RS20175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FPL05_RS20180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FPL05_RS20190	COG0356	it plays a direct role in the translocation of protons across the membrane
FPL05_RS20210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL05_RS20220	COG0508	dehydrogenase complex catalyzes the overall conversion of
FPL05_RS20260	COG2011	ABC-type metal ion transport system permease component
FPL05_RS20265	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FPL05_RS20270	COG0697	spore germination
FPL05_RS20275	COG1666	GTP binding
FPL05_RS20285	COG0784	Response regulator, receiver
FPL05_RS20285	COG2198	Histidine kinase
FPL05_RS20285	COG5002	protein histidine kinase activity
FPL05_RS20310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FPL05_RS20320	COG2813	Specifically methylates the guanine in position
FPL05_RS20340	COG2202	Pas domain
FPL05_RS20340	COG2205	protein histidine kinase activity
FPL05_RS20360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FPL05_RS20365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL05_RS20420	COG0842	Transport permease protein
FPL05_RS20425	COG1131	(ABC) transporter
FPL05_RS20430	COG0025	NhaP-type Na H and K H
FPL05_RS20440	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FPL05_RS20445	COG1573	uracil-dna glycosylase
FPL05_RS20455	COG3384	dioxygenase
FPL05_RS20465	COG0583	DNA-binding transcription factor activity
FPL05_RS20475	COG0667	Aldo Keto reductase
FPL05_RS20490	COG3590	peptidase
FPL05_RS20510	COG0531	amino acid
FPL05_RS20525	COG2972	Histidine kinase
FPL05_RS20550	COG3685	Protein conserved in bacteria
FPL05_RS20555	COG3546	catalase activity
FPL05_RS20605	COG1271	oxidase subunit
FPL05_RS20610	COG1294	oxidase, subunit
FPL05_RS20625	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS20630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FPL05_RS20650	COG1132	(ABC) transporter
FPL05_RS20665	COG1063	alcohol dehydrogenase
FPL05_RS20740	COG0251	oxidation-reduction process
FPL05_RS20755	COG0840	transmembrane signaling receptor activity
FPL05_RS20770	COG0583	DNA-binding transcription factor activity
FPL05_RS20775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FPL05_RS20820	COG0024	Methionine aminopeptidase
FPL05_RS20915	COG0582	viral genome integration into host DNA
FPL05_RS20945	COG4695	Portal protein
FPL05_RS20990	COG3179	chitinase
FPL05_RS21195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FPL05_RS21200	COG1490	D-aminoacyl-tRNA deacylase activity
FPL05_RS21205	COG1560	Kdo2-lipid A biosynthetic process
FPL05_RS21260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FPL05_RS21260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FPL05_RS21265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FPL05_RS21270	COG0242	peptide deformylase activity
FPL05_RS21275	COG1652	LysM domain
FPL05_RS21280	COG0758	DNA mediated transformation
FPL05_RS21300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FPL05_RS21300	COG1754	DNA topoisomerase type I activity
FPL05_RS21305	COG0009	L-threonylcarbamoyladenylate synthase
FPL05_RS21320	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS21335	COG0616	signal peptide processing
FPL05_RS21340	COG0534	Mate efflux family protein
FPL05_RS21360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FPL05_RS21365	COG0625	glutathione transferase activity
FPL05_RS21380	COG1252	NADH dehydrogenase
FPL05_RS21385	COG2860	membrane
FPL05_RS21390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FPL05_RS21395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FPL05_RS21400	COG3437	response regulator, receiver
FPL05_RS21405	COG2177	Part of the ABC transporter FtsEX involved in
FPL05_RS21410	COG2884	Cell division ATP-binding protein ftsE
FPL05_RS21420	COG3118	belongs to the thioredoxin family
FPL05_RS21425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FPL05_RS21430	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FPL05_RS21435	COG0583	DNA-binding transcription factor activity
FPL05_RS21455	COG1652	LysM domain
FPL05_RS21460	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FPL05_RS21460	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FPL05_RS21465	COG1473	amidohydrolase
FPL05_RS21470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL05_RS21475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL05_RS21485	COG5383	Protein conserved in bacteria
FPL05_RS21530	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FPL05_RS21535	COG3023	N-Acetylmuramoyl-L-alanine amidase
FPL05_RS21545	COG4948	Mandelate Racemase Muconate Lactonizing
FPL05_RS21555	COG0531	amino acid
FPL05_RS21570	COG4682	membrane
FPL05_RS21585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FPL05_RS21590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FPL05_RS21600	COG1610	YqeY-like protein
FPL05_RS21610	COG1295	ribonuclease BN
FPL05_RS21615	COG0358	DNA primase activity
FPL05_RS21630	COG0109	protoheme IX farnesyltransferase activity
FPL05_RS21660	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FPL05_RS21675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FPL05_RS21720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FPL05_RS21725	COG0739	heme binding
FPL05_RS21730	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FPL05_RS21740	COG2211	Major facilitator Superfamily
FPL05_RS21745	COG0708	Exodeoxyribonuclease III
FPL05_RS21750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FPL05_RS21760	COG1192	Involved in chromosome partitioning
FPL05_RS21765	COG1475	DNA binding
FPL05_RS21785	COG0463	Glycosyl transferase, family 2
FPL05_RS21805	COG0756	dUTP diphosphatase activity
FPL05_RS21810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FPL05_RS21815	COG2003	Belongs to the UPF0758 family
FPL05_RS21820	COG0018	arginyl-trna synthetase
FPL05_RS21835	COG4221	oxidoreductase activity
FPL05_RS21850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL05_RS21855	COG1166	arginine decarboxylase activity
FPL05_RS21860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FPL05_RS21885	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FPL05_RS21885	COG3291	Pkd domain containing protein
FPL05_RS21895	COG0347	Belongs to the P(II) protein family
FPL05_RS21905	COG0606	chelatase, subunit chli
FPL05_RS21920	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FPL05_RS21955	COG1690	Belongs to the RtcB family
FPL05_RS21990	COG1090	epimerase
FPL05_RS22000	COG0642	Histidine kinase
FPL05_RS22030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FPL05_RS22055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FPL05_RS22060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FPL05_RS22075	COG0753	catalase activity
FPL05_RS22090	COG2197	response regulator
FPL05_RS22095	COG4585	Histidine kinase
FPL05_RS22100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL05_RS22105	COG1136	(ABC) transporter
FPL05_RS22130	COG0697	spore germination
FPL05_RS22150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL05_RS22155	COG0180	Tryptophanyl-tRNA synthetase
FPL05_RS22160	COG3237	CsbD-like
FPL05_RS22205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FPL05_RS22240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FPL05_RS22245	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FPL05_RS22245	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FPL05_RS22290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPL05_RS22320	COG1199	ATP-dependent helicase activity
FPL05_RS22335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FPL05_RS22400	COG0625	glutathione transferase activity
FPL05_RS22440	COG4555	ABC transporter
FPL05_RS22450	COG1476	TRANSCRIPTIONal
FPL05_RS22495	COG0633	Ferredoxin
FPL05_RS22495	COG0543	2 iron, 2 sulfur cluster binding
FPL05_RS22500	COG1131	(ABC) transporter
FPL05_RS22505	COG0842	Transport permease protein
FPL05_RS22515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FPL05_RS22550	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FPL05_RS22560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FPL05_RS22575	COG1042	CoA-binding domain protein
FPL05_RS22575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FPL05_RS22575	COG0045	succinate-CoA ligase (ADP-forming) activity
FPL05_RS22580	COG2239	Acts as a magnesium transporter
FPL05_RS22600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FPL05_RS22605	COG3387	PFAM Glycoside hydrolase 15-related
FPL05_RS22620	COG3100	YcgL domain-containing protein
FPL05_RS22625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FPL05_RS22635	COG0463	Glycosyl transferase, family 2
FPL05_RS22645	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS22680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPL05_RS22695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPL05_RS22725	COG0823	Involved in the tonB-independent uptake of proteins
FPL05_RS22725	COG1506	peptidase
FPL05_RS22725	COG4946	Tricorn protease homolog
FPL05_RS22745	COG0408	coproporphyrinogen oxidase activity
FPL05_RS22785	COG0515	serine threonine protein kinase
FPL05_RS22785	COG2815	serine threonine protein kinase
FPL05_RS22790	COG0631	protein serine/threonine phosphatase activity
FPL05_RS23005	COG0210	DNA helicase
FPL05_RS23020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL05_RS23025	COG0583	DNA-binding transcription factor activity
FPL05_RS23030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FPL05_RS23045	COG2159	amidohydrolase
FPL05_RS23070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL05_RS23090	COG0357	Ribosomal RNA small subunit methyltransferase G
FPL05_RS23095	COG3540	Alkaline phosphatase
FPL05_RS23105	COG2091	lysine biosynthetic process via aminoadipic acid
FPL05_RS23120	COG0708	Exodeoxyribonuclease III
FPL05_RS23125	COG1940	carbohydrate kinase activity
FPL05_RS23125	COG1846	Transcriptional regulator
FPL05_RS23135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL05_RS23145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FPL05_RS23150	COG3162	membrane
FPL05_RS23160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FPL05_RS23190	COG3507	Belongs to the glycosyl hydrolase 43 family
FPL05_RS23210	COG1028	Short-chain dehydrogenase reductase Sdr
FPL05_RS23215	COG0179	Fumarylacetoacetate (FAA) hydrolase
FPL05_RS23225	COG4948	Mandelate Racemase Muconate Lactonizing
FPL05_RS23230	COG3254	rhamnose metabolic process
FPL05_RS23235	COG0738	Major facilitator superfamily
FPL05_RS23240	COG1414	Transcriptional regulator
FPL05_RS23245	COG1971	Probably functions as a manganese efflux pump
FPL05_RS23250	COG2205	protein histidine kinase activity
FPL05_RS23265	COG3459	Glycosyltransferase 36 associated
FPL05_RS23270	COG2211	Major facilitator Superfamily
FPL05_RS23275	COG3265	gluconokinase activity
FPL05_RS23285	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL05_RS23305	COG2911	Protein conserved in bacteria
FPL05_RS23310	COG0729	surface antigen
FPL05_RS23345	COG0752	glycyl-tRNA synthetase alpha subunit
FPL05_RS23350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FPL05_RS23375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FPL05_RS23375	COG0519	Catalyzes the synthesis of GMP from XMP
FPL05_RS23385	COG0805	protein transport
FPL05_RS23390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FPL05_RS23395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FPL05_RS23405	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FPL05_RS23430	COG2974	May be involved in recombination
FPL05_RS23435	COG0037	tRNA processing
FPL05_RS23445	COG2115	Belongs to the xylose isomerase family
FPL05_RS23455	COG3661	Belongs to the glycosyl hydrolase 67 family
FPL05_RS23465	COG4948	Mandelate Racemase Muconate Lactonizing
FPL05_RS23475	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL05_RS23480	COG0246	Mannitol dehydrogenase
FPL05_RS23530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FPL05_RS23560	COG3386	PFAM SMP-30 Gluconolaconase
FPL05_RS23570	COG3250	beta-galactosidase activity
FPL05_RS23575	COG1904	glucuronate isomerase
FPL05_RS23580	COG3693	PFAM glycoside hydrolase, family 10
FPL05_RS23590	COG3693	PFAM glycoside hydrolase, family 10
FPL05_RS23605	COG2211	Major facilitator Superfamily
FPL05_RS23645	COG2937	Belongs to the GPAT DAPAT family
FPL05_RS23680	COG0284	orotidine-5'-phosphate decarboxylase activity
FPL05_RS23685	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FPL05_RS23695	COG3132	Protein of unknown function, DUF480
FPL05_RS23710	COG0210	DNA helicase
FPL05_RS23715	COG1435	thymidine kinase activity
FPL05_RS23725	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FPL05_RS23735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FPL05_RS23765	COG3135	benzoate transporter
FPL05_RS23785	COG0676	glucose-6-phosphate 1-epimerase activity
FPL05_RS23795	COG3012	SEC-C Motif Domain Protein
FPL05_RS23800	COG0730	response to heat
FPL05_RS23820	COG0302	gtp cyclohydrolase
FPL05_RS23835	COG1566	PFAM secretion protein HlyD family protein
FPL05_RS23845	COG1289	transmembrane transporter activity
FPL05_RS23850	COG0477	Major facilitator Superfamily
FPL05_RS23860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL05_RS23880	COG4691	Plasmid stability protein
FPL05_RS23885	COG1487	ribonuclease activity
FPL05_RS23920	COG0564	pseudouridine synthase activity
FPL05_RS23935	COG0439	Biotin carboxylase
FPL05_RS23975	COG1074	ATP-dependent DNA helicase activity
FPL05_RS23980	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FPL05_RS23995	COG1127	ABC transporter
FPL05_RS24000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPL05_RS24005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPL05_RS24020	COG2853	Lipoprotein
FPL05_RS24030	COG0386	Belongs to the glutathione peroxidase family
FPL05_RS24040	COG1322	Protein conserved in bacteria
FPL05_RS24045	COG0604	alcohol dehydrogenase
FPL05_RS24050	COG0583	DNA-binding transcription factor activity
FPL05_RS24065	COG0625	glutathione transferase activity
FPL05_RS24075	COG0531	amino acid
FPL05_RS24080	COG3537	Alpha-1,2-mannosidase
FPL05_RS24095	COG3706	GGDEF domain
FPL05_RS24100	COG3835	regulator
FPL05_RS24105	COG1929	Belongs to the glycerate kinase type-1 family
FPL05_RS24110	COG2271	Major facilitator Superfamily
FPL05_RS24125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FPL05_RS24135	COG0861	Integral membrane protein TerC family
FPL05_RS24150	COG0584	glycerophosphoryl diester phosphodiesterase
FPL05_RS24165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FPL05_RS24170	COG0726	polysaccharide deacetylase
FPL05_RS24175	COG0706	membrane insertase activity
FPL05_RS24180	COG0594	ribonuclease P activity