locus-tag	class	description
CIW71_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CIW71_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CIW71_RS00020	COG0187	DNA topoisomerase II activity
CIW71_RS00030	COG0501	Belongs to the peptidase M48B family
CIW71_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CIW71_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW71_RS00105	COG2003	Belongs to the UPF0758 family
CIW71_RS00195	COG0793	Belongs to the peptidase S41A family
CIW71_RS00200	COG4942	peptidase
CIW71_RS00210	COG2234	aminopeptidase activity
CIW71_RS00220	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CIW71_RS00230	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CIW71_RS00240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CIW71_RS00250	COG1064	alcohol dehydrogenase
CIW71_RS00255	COG0493	'glutamate synthase
CIW71_RS00260	COG0069	glutamate synthase activity
CIW71_RS00260	COG0070	glutamate synthase
CIW71_RS00260	COG0067	glutamate synthase
CIW71_RS00310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CIW71_RS00325	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CIW71_RS00330	COG0438	transferase activity, transferring glycosyl groups
CIW71_RS00330	COG0297	glycogen (starch) synthase activity
CIW71_RS00350	COG0367	asparagine synthase
CIW71_RS00380	COG1132	(ABC) transporter
CIW71_RS00410	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CIW71_RS00505	COG1205	dead DEAH box helicase
CIW71_RS00505	COG1111	helicase
CIW71_RS00510	COG1272	protein, Hemolysin III
CIW71_RS00530	COG0300	oxidoreductase activity
CIW71_RS00535	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS00590	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CIW71_RS00595	COG3710	Transcriptional regulator
CIW71_RS00615	COG2197	response regulator
CIW71_RS00620	COG4585	Histidine kinase
CIW71_RS00635	COG1304	FMN binding
CIW71_RS00690	COG0662	Cupin 2, conserved barrel domain protein
CIW71_RS00700	COG4772	TonB-dependent receptor
CIW71_RS00710	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CIW71_RS00740	COG0714	Associated with various cellular activities
CIW71_RS00790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIW71_RS00835	COG0366	Alpha amylase catalytic
CIW71_RS00840	COG0366	Alpha amylase catalytic
CIW71_RS00845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CIW71_RS00940	COG3504	Conjugal transfer protein
CIW71_RS00945	COG2948	multi-organism process
CIW71_RS01010	COG3041	Addiction module toxin RelE StbE family
CIW71_RS01015	COG3077	Addiction module antitoxin, RelB DinJ family
CIW71_RS01045	COG1192	Involved in chromosome partitioning
CIW71_RS01080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CIW71_RS01090	COG3265	gluconokinase activity
CIW71_RS01095	COG2211	Major facilitator Superfamily
CIW71_RS01100	COG3459	Glycosyltransferase 36 associated
CIW71_RS01115	COG2205	protein histidine kinase activity
CIW71_RS01120	COG1971	Probably functions as a manganese efflux pump
CIW71_RS01130	COG1414	Transcriptional regulator
CIW71_RS01135	COG0738	Major facilitator superfamily
CIW71_RS01140	COG3254	rhamnose metabolic process
CIW71_RS01145	COG4948	Mandelate Racemase Muconate Lactonizing
CIW71_RS01155	COG0179	Fumarylacetoacetate (FAA) hydrolase
CIW71_RS01160	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS01210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CIW71_RS01220	COG3162	membrane
CIW71_RS01225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CIW71_RS01235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CIW71_RS01245	COG1940	carbohydrate kinase activity
CIW71_RS01245	COG1846	Transcriptional regulator
CIW71_RS01250	COG0708	Exodeoxyribonuclease III
CIW71_RS01265	COG2091	lysine biosynthetic process via aminoadipic acid
CIW71_RS01275	COG3540	Alkaline phosphatase
CIW71_RS01280	COG0357	Ribosomal RNA small subunit methyltransferase G
CIW71_RS01300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW71_RS01325	COG2159	amidohydrolase
CIW71_RS01340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CIW71_RS01345	COG0583	DNA-binding transcription factor activity
CIW71_RS01350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW71_RS01365	COG0210	DNA helicase
CIW71_RS01545	COG0631	protein serine/threonine phosphatase activity
CIW71_RS01550	COG0515	serine threonine protein kinase
CIW71_RS01550	COG2815	serine threonine protein kinase
CIW71_RS01590	COG0408	coproporphyrinogen oxidase activity
CIW71_RS01610	COG4946	Tricorn protease homolog
CIW71_RS01610	COG0823	Involved in the tonB-independent uptake of proteins
CIW71_RS01610	COG1506	peptidase
CIW71_RS01640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CIW71_RS01655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CIW71_RS01695	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS01715	COG0463	Glycosyl transferase, family 2
CIW71_RS01725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CIW71_RS01730	COG3100	YcgL domain-containing protein
CIW71_RS01745	COG3387	PFAM Glycoside hydrolase 15-related
CIW71_RS01750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CIW71_RS01770	COG2239	Acts as a magnesium transporter
CIW71_RS01775	COG0045	succinate-CoA ligase (ADP-forming) activity
CIW71_RS01775	COG1042	CoA-binding domain protein
CIW71_RS01775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIW71_RS01795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CIW71_RS01805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CIW71_RS01840	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CIW71_RS01850	COG0842	Transport permease protein
CIW71_RS01855	COG1131	(ABC) transporter
CIW71_RS01860	COG0543	2 iron, 2 sulfur cluster binding
CIW71_RS01860	COG0633	Ferredoxin
CIW71_RS01905	COG1476	TRANSCRIPTIONal
CIW71_RS01915	COG4555	ABC transporter
CIW71_RS01955	COG0625	glutathione transferase activity
CIW71_RS02030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CIW71_RS02045	COG1199	ATP-dependent helicase activity
CIW71_RS02075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CIW71_RS02120	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CIW71_RS02120	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CIW71_RS02125	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CIW71_RS02155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CIW71_RS02200	COG3237	CsbD-like
CIW71_RS02205	COG0180	Tryptophanyl-tRNA synthetase
CIW71_RS02210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIW71_RS02230	COG0697	spore germination
CIW71_RS02255	COG1136	(ABC) transporter
CIW71_RS02260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW71_RS02265	COG4585	Histidine kinase
CIW71_RS02270	COG2197	response regulator
CIW71_RS02285	COG0753	catalase activity
CIW71_RS02300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIW71_RS02305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CIW71_RS02330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CIW71_RS02360	COG0642	Histidine kinase
CIW71_RS02370	COG1090	epimerase
CIW71_RS02405	COG1690	Belongs to the RtcB family
CIW71_RS02445	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CIW71_RS02460	COG0606	chelatase, subunit chli
CIW71_RS02500	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CIW71_RS02505	COG1166	arginine decarboxylase activity
CIW71_RS02510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CIW71_RS02525	COG4221	oxidoreductase activity
CIW71_RS02540	COG0018	arginyl-trna synthetase
CIW71_RS02545	COG2003	Belongs to the UPF0758 family
CIW71_RS02550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CIW71_RS02555	COG0756	dUTP diphosphatase activity
CIW71_RS02575	COG0463	Glycosyl transferase, family 2
CIW71_RS02595	COG1475	DNA binding
CIW71_RS02600	COG1192	Involved in chromosome partitioning
CIW71_RS02610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CIW71_RS02615	COG0708	Exodeoxyribonuclease III
CIW71_RS02620	COG2211	Major facilitator Superfamily
CIW71_RS02630	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CIW71_RS02635	COG0739	heme binding
CIW71_RS02640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CIW71_RS02685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CIW71_RS02700	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CIW71_RS02730	COG0109	protoheme IX farnesyltransferase activity
CIW71_RS02745	COG0358	DNA primase activity
CIW71_RS02750	COG1295	ribonuclease BN
CIW71_RS02760	COG1610	YqeY-like protein
CIW71_RS02770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CIW71_RS02775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CIW71_RS02785	COG2133	pyrroloquinoline quinone binding
CIW71_RS02790	COG4682	membrane
CIW71_RS02805	COG0531	amino acid
CIW71_RS02815	COG4948	Mandelate Racemase Muconate Lactonizing
CIW71_RS02825	COG3023	N-Acetylmuramoyl-L-alanine amidase
CIW71_RS02830	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CIW71_RS02880	COG5383	Protein conserved in bacteria
CIW71_RS02890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIW71_RS02895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW71_RS02900	COG1473	amidohydrolase
CIW71_RS02905	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CIW71_RS02905	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CIW71_RS02930	COG0583	DNA-binding transcription factor activity
CIW71_RS02935	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CIW71_RS02945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CIW71_RS02950	COG3118	belongs to the thioredoxin family
CIW71_RS02960	COG2884	Cell division ATP-binding protein ftsE
CIW71_RS02965	COG2177	Part of the ABC transporter FtsEX involved in
CIW71_RS02970	COG3437	response regulator, receiver
CIW71_RS02975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CIW71_RS02980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CIW71_RS02985	COG2860	membrane
CIW71_RS02990	COG1252	NADH dehydrogenase
CIW71_RS03005	COG0625	glutathione transferase activity
CIW71_RS03010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CIW71_RS03030	COG0534	Mate efflux family protein
CIW71_RS03035	COG0616	signal peptide processing
CIW71_RS03045	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS03060	COG0009	L-threonylcarbamoyladenylate synthase
CIW71_RS03065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIW71_RS03065	COG1754	DNA topoisomerase type I activity
CIW71_RS03085	COG0758	DNA mediated transformation
CIW71_RS03090	COG1652	LysM domain
CIW71_RS03095	COG0242	peptide deformylase activity
CIW71_RS03100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CIW71_RS03105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIW71_RS03105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CIW71_RS03160	COG1560	Kdo2-lipid A biosynthetic process
CIW71_RS03165	COG1490	D-aminoacyl-tRNA deacylase activity
CIW71_RS03170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CIW71_RS03185	COG0582	viral genome integration into host DNA
CIW71_RS03220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CIW71_RS03250	COG0024	Methionine aminopeptidase
CIW71_RS03295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CIW71_RS03300	COG0583	DNA-binding transcription factor activity
CIW71_RS03385	COG1063	alcohol dehydrogenase
CIW71_RS03400	COG1132	(ABC) transporter
CIW71_RS03420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CIW71_RS03425	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS03440	COG1294	oxidase, subunit
CIW71_RS03445	COG1271	oxidase subunit
CIW71_RS03495	COG3546	catalase activity
CIW71_RS03500	COG3685	Protein conserved in bacteria
CIW71_RS03530	COG2972	Histidine kinase
CIW71_RS03545	COG0531	amino acid
CIW71_RS03565	COG3590	peptidase
CIW71_RS03580	COG0667	Aldo Keto reductase
CIW71_RS03590	COG0583	DNA-binding transcription factor activity
CIW71_RS03600	COG3384	dioxygenase
CIW71_RS03610	COG1573	uracil-dna glycosylase
CIW71_RS03615	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CIW71_RS03625	COG0025	NhaP-type Na H and K H
CIW71_RS03630	COG1131	(ABC) transporter
CIW71_RS03635	COG0842	Transport permease protein
CIW71_RS03695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIW71_RS03700	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CIW71_RS03720	COG2202	Pas domain
CIW71_RS03720	COG2205	protein histidine kinase activity
CIW71_RS03745	COG1187	pseudouridine synthase activity
CIW71_RS03750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CIW71_RS03775	COG0784	Response regulator, receiver
CIW71_RS03775	COG2198	Histidine kinase
CIW71_RS03775	COG5002	protein histidine kinase activity
CIW71_RS03785	COG1666	GTP binding
CIW71_RS03790	COG0697	spore germination
CIW71_RS03795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CIW71_RS03800	COG2011	ABC-type metal ion transport system permease component
CIW71_RS03860	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIW71_RS03870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CIW71_RS03890	COG0356	it plays a direct role in the translocation of protons across the membrane
CIW71_RS03900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CIW71_RS03905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CIW71_RS03910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CIW71_RS03915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CIW71_RS03920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CIW71_RS03925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CIW71_RS03940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CIW71_RS03945	COG4191	Histidine kinase
CIW71_RS03960	COG0577	efflux transmembrane transporter activity
CIW71_RS03965	COG0577	efflux transmembrane transporter activity
CIW71_RS03970	COG4591	ABC-type transport system involved in lipoprotein release permease component
CIW71_RS03970	COG1136	(ABC) transporter
CIW71_RS03975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW71_RS03980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CIW71_RS04035	COG0339	signal peptide processing
CIW71_RS04050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CIW71_RS04055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CIW71_RS04070	COG2819	hydrolase of the alpha beta superfamily
CIW71_RS04080	COG1956	GAF domain-containing protein
CIW71_RS04085	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CIW71_RS04095	COG0720	synthase
CIW71_RS04105	COG4206	TonB-dependent receptor
CIW71_RS04115	COG0513	Belongs to the DEAD box helicase family
CIW71_RS04130	COG0625	glutathione transferase activity
CIW71_RS04160	COG0626	cystathionine gamma-synthase activity
CIW71_RS04170	COG0438	transferase activity, transferring glycosyl groups
CIW71_RS04190	COG0438	transferase activity, transferring glycosyl groups
CIW71_RS04195	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CIW71_RS04230	COG0463	Glycosyl transferase, family 2
CIW71_RS04245	COG2086	electron transfer activity
CIW71_RS04275	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CIW71_RS04275	COG0662	Cupin 2, conserved barrel domain protein
CIW71_RS04280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIW71_RS04310	COG3218	ABC-type transport auxiliary lipoprotein component
CIW71_RS04310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CIW71_RS04315	COG1127	ABC transporter
CIW71_RS04320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CIW71_RS04335	COG0442	prolyl-tRNA aminoacylation
CIW71_RS04345	COG1183	phosphatidylcholine synthase activity
CIW71_RS04375	COG0525	valine-tRNA ligase activity
CIW71_RS04390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIW71_RS04400	COG0795	lipopolysaccharide-transporting ATPase activity
CIW71_RS04415	COG4974	Belongs to the 'phage' integrase family
CIW71_RS04430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CIW71_RS04445	COG0047	phosphoribosylformylglycinamidine synthase activity
CIW71_RS04445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CIW71_RS04455	COG1404	Belongs to the peptidase S8 family
CIW71_RS04460	COG5295	Hep Hag repeat protein
CIW71_RS04465	COG1404	Belongs to the peptidase S8 family
CIW71_RS04470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CIW71_RS04480	COG1459	type II secretion system
CIW71_RS04485	COG2165	general secretion pathway protein
CIW71_RS04490	COG4970	Tfp pilus assembly protein FimT
CIW71_RS04495	COG2165	general secretion pathway protein
CIW71_RS04500	COG4795	General secretion pathway protein
CIW71_RS04505	COG3156	type II secretion system protein K
CIW71_RS04510	COG3166	PFAM Fimbrial assembly family protein
CIW71_RS04525	COG1450	Type ii and iii secretion system protein
CIW71_RS04540	COG2188	Transcriptional regulator
CIW71_RS04595	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CIW71_RS04610	COG1215	transferase activity, transferring glycosyl groups
CIW71_RS04615	COG1215	transferase activity, transferring glycosyl groups
CIW71_RS04620	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CIW71_RS04625	COG0457	Tetratricopeptide repeat
CIW71_RS04655	COG0242	peptide deformylase activity
CIW71_RS04660	COG1307	EDD domain protein, DegV family
CIW71_RS04685	COG0402	S-adenosylhomocysteine deaminase activity
CIW71_RS04690	COG3964	amidohydrolase
CIW71_RS04705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CIW71_RS04710	COG0726	polysaccharide deacetylase
CIW71_RS04715	COG4773	Receptor
CIW71_RS04790	COG1162	GTPase activity
CIW71_RS04815	COG2211	Major facilitator Superfamily
CIW71_RS04820	COG1609	Transcriptional regulator
CIW71_RS04825	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS04830	COG2851	Citrate transporter
CIW71_RS04850	COG0642	Histidine kinase
CIW71_RS04860	COG2197	response regulator
CIW71_RS04875	COG0667	Aldo Keto reductase
CIW71_RS04880	COG0583	DNA-binding transcription factor activity
CIW71_RS04910	COG1301	dicarboxylic acid transport
CIW71_RS04915	COG0281	malic enzyme
CIW71_RS04915	COG0280	phosphate acetyltransferase
CIW71_RS04940	COG1560	Kdo2-lipid A biosynthetic process
CIW71_RS04950	COG1519	Transferase
CIW71_RS04955	COG1538	Outer membrane efflux protein
CIW71_RS04960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CIW71_RS04980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CIW71_RS04985	COG0066	3-isopropylmalate dehydratase activity
CIW71_RS04990	COG0473	3-isopropylmalate dehydrogenase activity
CIW71_RS04995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CIW71_RS05015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CIW71_RS05020	COG0405	Gamma-glutamyltransferase
CIW71_RS05025	COG0840	transmembrane signaling receptor activity
CIW71_RS05040	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CIW71_RS05045	COG3710	Transcriptional regulator
CIW71_RS05065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CIW71_RS05075	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CIW71_RS05095	COG0563	adenylate kinase activity
CIW71_RS05100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CIW71_RS05115	COG3781	membrane
CIW71_RS05120	COG0671	phosphoesterase, PA-phosphatase related
CIW71_RS05130	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS05135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CIW71_RS05140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CIW71_RS05170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CIW71_RS05185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CIW71_RS05200	COG0352	thiamine-phosphate diphosphorylase activity
CIW71_RS05205	COG1773	rubredoxin
CIW71_RS05210	COG2912	Transglutaminase-like superfamily
CIW71_RS05220	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CIW71_RS05230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CIW71_RS05250	COG3079	Belongs to the UPF0149 family
CIW71_RS05255	COG0006	proline dipeptidase activity
CIW71_RS05265	COG0006	proline dipeptidase activity
CIW71_RS05280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIW71_RS05285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CIW71_RS05295	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CIW71_RS05300	COG1561	YicC-like family, N-terminal region
CIW71_RS05305	COG0194	GDP metabolic process
CIW71_RS05315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CIW71_RS05325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CIW71_RS05350	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CIW71_RS05385	COG0714	Associated with various cellular activities
CIW71_RS05405	COG2304	oxidoreductase activity
CIW71_RS05420	COG1301	dicarboxylic acid transport
CIW71_RS05425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CIW71_RS05435	COG4773	Receptor
CIW71_RS05445	COG0739	heme binding
CIW71_RS05490	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CIW71_RS05495	COG4149	molybdate abc transporter
CIW71_RS05500	COG0725	ABC transporter, periplasmic molybdate-binding protein
CIW71_RS05505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIW71_RS05505	COG3453	Protein conserved in bacteria
CIW71_RS05515	COG3047	cAMP biosynthetic process
CIW71_RS05520	COG3047	cAMP biosynthetic process
CIW71_RS05530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CIW71_RS05555	COG0126	phosphoglycerate kinase activity
CIW71_RS05565	COG0469	pyruvate kinase activity
CIW71_RS05580	COG3588	fructose-bisphosphate aldolase
CIW71_RS05585	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CIW71_RS05600	COG1648	precorrin-2 dehydrogenase activity
CIW71_RS05600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CIW71_RS05620	COG2198	Histidine kinase
CIW71_RS05620	COG2205	protein histidine kinase activity
CIW71_RS05620	COG0784	Response regulator, receiver
CIW71_RS05640	COG0175	sulfate reduction
CIW71_RS05645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CIW71_RS05650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CIW71_RS05655	COG0175	sulfate reduction
CIW71_RS05660	COG2895	sulfate adenylyltransferase (ATP) activity
CIW71_RS05660	COG0529	Catalyzes the synthesis of activated sulfate
CIW71_RS05670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIW71_RS05695	COG0308	aminopeptidase N
CIW71_RS05705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CIW71_RS05720	COG4948	Mandelate Racemase Muconate Lactonizing
CIW71_RS05725	COG3250	beta-galactosidase activity
CIW71_RS05735	COG1609	Transcriptional regulator
CIW71_RS05745	COG1970	mechanosensitive ion channel activity
CIW71_RS05770	COG0471	metal ion transport
CIW71_RS05770	COG3273	potassium ion transport
CIW71_RS05775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CIW71_RS05785	COG2022	thiamine diphosphate biosynthetic process
CIW71_RS05810	COG1752	Esterase of the alpha-beta hydrolase superfamily
CIW71_RS05940	COG0189	ligase activity
CIW71_RS05950	COG0745	RESPONSE REGULATOR receiver
CIW71_RS05955	COG5002	protein histidine kinase activity
CIW71_RS05985	COG0237	dephospho-CoA kinase activity
CIW71_RS05990	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CIW71_RS06005	COG4969	Belongs to the N-Me-Phe pilin family
CIW71_RS06030	COG0045	succinate-CoA ligase (ADP-forming) activity
CIW71_RS06035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CIW71_RS06050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIW71_RS06050	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CIW71_RS06060	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CIW71_RS06065	COG0564	pseudouridine synthase activity
CIW71_RS06080	COG3011	Protein conserved in bacteria
CIW71_RS06085	COG0840	transmembrane signaling receptor activity
CIW71_RS06105	COG3387	PFAM Glycoside hydrolase 15-related
CIW71_RS06110	COG1877	trehalose-phosphatase activity
CIW71_RS06150	COG2827	Endonuclease containing a URI domain
CIW71_RS06155	COG4771	TonB-dependent receptor
CIW71_RS06165	COG0667	Aldo Keto reductase
CIW71_RS06170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CIW71_RS06175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIW71_RS06180	COG1116	anion transmembrane transporter activity
CIW71_RS06185	COG0542	response to heat
CIW71_RS06190	COG4206	TonB-dependent receptor
CIW71_RS06210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CIW71_RS06220	COG1492	cobalamin metabolic process
CIW71_RS06230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CIW71_RS06250	COG0019	diaminopimelate decarboxylase activity
CIW71_RS06265	COG4264	IucA IucC family
CIW71_RS06275	COG4772	TonB-dependent receptor
CIW71_RS06300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CIW71_RS06300	COG4651	solute:proton antiporter activity
CIW71_RS06340	COG0488	(ABC) transporter
CIW71_RS06380	COG0477	Major facilitator Superfamily
CIW71_RS06395	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CIW71_RS06410	COG0217	transcriptional regulatory protein
CIW71_RS06415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CIW71_RS06420	COG0632	four-way junction helicase activity
CIW71_RS06425	COG3158	transport of potassium into the cell
CIW71_RS06435	COG2255	four-way junction helicase activity
CIW71_RS06440	COG0824	Thioesterase
CIW71_RS06450	COG0848	biopolymer transport protein
CIW71_RS06460	COG0823	Involved in the tonB-independent uptake of proteins
CIW71_RS06465	COG2885	chlorophyll binding
CIW71_RS06475	COG0602	queuosine metabolic process
CIW71_RS06485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CIW71_RS06490	COG3920	Histidine kinase
CIW71_RS06510	COG0840	transmembrane signaling receptor activity
CIW71_RS06545	COG0514	ATP-dependent DNA helicase (RecQ)
CIW71_RS06555	COG0783	Belongs to the Dps family
CIW71_RS06560	COG1643	Atp-dependent helicase
CIW71_RS06575	COG0837	glucose binding
CIW71_RS06590	COG0535	radical SAM domain protein
CIW71_RS06595	COG0535	radical SAM domain protein
CIW71_RS06600	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CIW71_RS06605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CIW71_RS06615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CIW71_RS06630	COG1215	transferase activity, transferring glycosyl groups
CIW71_RS06635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIW71_RS06645	COG1199	ATP-dependent helicase activity
CIW71_RS06655	COG1397	ADP-ribosylglycohydrolase
CIW71_RS06665	COG0189	ligase activity
CIW71_RS06680	COG0835	chemotaxis
CIW71_RS06685	COG0840	transmembrane signaling receptor activity
CIW71_RS06690	COG2198	Histidine kinase
CIW71_RS06690	COG0784	Response regulator, receiver
CIW71_RS06690	COG0643	Histidine kinase
CIW71_RS06725	COG1446	asparaginase
CIW71_RS06730	COG3142	Participates in the control of copper homeostasis
CIW71_RS06770	COG3537	Alpha-1,2-mannosidase
CIW71_RS06815	COG1472	Belongs to the glycosyl hydrolase 3 family
CIW71_RS06830	COG1388	LysM domain
CIW71_RS06830	COG3858	chitin binding
CIW71_RS06845	COG0837	glucose binding
CIW71_RS06850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CIW71_RS06860	COG0494	nUDIX hydrolase
CIW71_RS06870	COG3956	TIGRFAM MazG family protein
CIW71_RS06875	COG1742	UPF0060 membrane protein
CIW71_RS06890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CIW71_RS06895	COG0509	glycine decarboxylation via glycine cleavage system
CIW71_RS06925	COG1960	acyl-CoA dehydrogenase activity
CIW71_RS06935	COG1309	transcriptional regulator
CIW71_RS06970	COG4771	TonB-dependent receptor
CIW71_RS06980	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CIW71_RS06985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIW71_RS06990	COG0463	Glycosyl transferase, family 2
CIW71_RS06995	COG0516	GMP reductase activity
CIW71_RS06995	COG0517	IMP dehydrogenase activity
CIW71_RS07000	COG2982	Protein involved in outer membrane biogenesis
CIW71_RS07005	COG1272	protein, Hemolysin III
CIW71_RS07010	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CIW71_RS07015	COG0739	heme binding
CIW71_RS07020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CIW71_RS07025	COG0626	cystathionine gamma-synthase activity
CIW71_RS07030	COG0527	aspartate kinase activity
CIW71_RS07030	COG0460	homoserine dehydrogenase
CIW71_RS07045	COG1760	l-serine dehydratase
CIW71_RS07065	COG2353	YceI-like domain
CIW71_RS07070	COG2198	Histidine kinase
CIW71_RS07070	COG0784	Response regulator, receiver
CIW71_RS07070	COG2205	protein histidine kinase activity
CIW71_RS07095	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CIW71_RS07105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CIW71_RS07110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CIW71_RS07115	COG0259	pyridoxamine-phosphate oxidase activity
CIW71_RS07125	COG1842	Phage shock protein A
CIW71_RS07150	COG0754	glutathionylspermidine amidase activity
CIW71_RS07270	COG0531	amino acid
CIW71_RS07275	COG2197	response regulator
CIW71_RS07315	COG1113	amino acid transport
CIW71_RS07325	COG1271	oxidase subunit
CIW71_RS07330	COG1294	oxidase, subunit
CIW71_RS07345	COG2239	Acts as a magnesium transporter
CIW71_RS07355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CIW71_RS07360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIW71_RS07370	COG1660	Displays ATPase and GTPase activities
CIW71_RS07375	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CIW71_RS07380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIW71_RS07395	COG1137	ATPase activity
CIW71_RS07400	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CIW71_RS07410	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CIW71_RS07420	COG0271	Belongs to the BolA IbaG family
CIW71_RS07425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CIW71_RS07445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CIW71_RS07460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CIW71_RS07470	COG0628	permease
CIW71_RS07480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CIW71_RS07485	COG3178	'Phosphotransferase
CIW71_RS07500	COG1555	photosystem II stabilization
CIW71_RS07515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CIW71_RS07520	COG1477	protein flavinylation
CIW71_RS07545	COG3128	pkhd-type hydroxylase
CIW71_RS07565	COG2146	nitrite reductase [NAD(P)H] activity
CIW71_RS07575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CIW71_RS07580	COG0719	Fe-S assembly protein
CIW71_RS07585	COG0396	ATPase activity
CIW71_RS07590	COG0719	Fe-S assembly protein
CIW71_RS07595	COG1959	2 iron, 2 sulfur cluster binding
CIW71_RS07605	COG0693	protein deglycase activity
CIW71_RS07625	COG0739	heme binding
CIW71_RS07640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CIW71_RS07665	COG0519	Catalyzes the synthesis of GMP from XMP
CIW71_RS07675	COG1678	Uncharacterized ACR, COG1678
CIW71_RS07680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CIW71_RS07685	COG0540	Belongs to the ATCase OTCase family
CIW71_RS07690	COG1764	response to oxidative stress
CIW71_RS07700	COG0384	phenazine biosynthesis protein PhzF
CIW71_RS07705	COG0384	phenazine biosynthesis protein PhzF
CIW71_RS07710	COG0527	aspartate kinase activity
CIW71_RS07725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CIW71_RS07740	COG0142	geranyltranstransferase activity
CIW71_RS07745	COG0629	single-stranded DNA binding
CIW71_RS07755	COG0604	alcohol dehydrogenase
CIW71_RS07755	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS07755	COG3321	synthase
CIW71_RS07760	COG2080	2 iron, 2 sulfur cluster binding
CIW71_RS07765	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CIW71_RS07770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CIW71_RS07775	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CIW71_RS07820	COG2879	small protein
CIW71_RS07825	COG1966	Carbon starvation protein
CIW71_RS07830	COG1741	Belongs to the pirin family
CIW71_RS07845	COG1741	Belongs to the pirin family
CIW71_RS07855	COG1515	deoxyribonuclease V activity
CIW71_RS07860	COG0588	phosphoglycerate mutase activity
CIW71_RS07870	COG3590	peptidase
CIW71_RS07875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW71_RS07880	COG2201	protein-glutamate methylesterase activity
CIW71_RS07885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CIW71_RS07890	COG2202	Pas domain
CIW71_RS07890	COG2200	EAL domain
CIW71_RS07890	COG2199	diguanylate cyclase activity
CIW71_RS07895	COG0835	chemotaxis
CIW71_RS07900	COG0840	transmembrane signaling receptor activity
CIW71_RS07905	COG2198	Histidine kinase
CIW71_RS07905	COG0643	Histidine kinase
CIW71_RS07940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CIW71_RS07950	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CIW71_RS07955	COG0745	RESPONSE REGULATOR receiver
CIW71_RS07960	COG2205	protein histidine kinase activity
CIW71_RS07975	COG4452	Inner membrane protein CreD
CIW71_RS08000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIW71_RS08005	COG0735	belongs to the Fur family
CIW71_RS08020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIW71_RS08030	COG1309	transcriptional regulator
CIW71_RS08035	COG0667	Aldo Keto reductase
CIW71_RS08050	COG2207	Transcriptional regulator
CIW71_RS08060	COG0583	DNA-binding transcription factor activity
CIW71_RS08065	COG2814	Major facilitator Superfamily
CIW71_RS08140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CIW71_RS08190	COG5002	protein histidine kinase activity
CIW71_RS08190	COG5001	Diguanylate cyclase
CIW71_RS08195	COG1187	pseudouridine synthase activity
CIW71_RS08220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CIW71_RS08230	COG0475	glutathione-regulated potassium exporter activity
CIW71_RS08240	COG0745	RESPONSE REGULATOR receiver
CIW71_RS08245	COG1538	Outer membrane efflux protein
CIW71_RS08275	COG1132	(ABC) transporter
CIW71_RS08325	COG2155	Conserved Protein
CIW71_RS08360	COG3118	belongs to the thioredoxin family
CIW71_RS08370	COG0495	leucyl-tRNA aminoacylation
CIW71_RS08385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CIW71_RS08400	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CIW71_RS08415	COG2968	Membrane
CIW71_RS08420	COG0424	maF-like protein
CIW71_RS08430	COG3164	Protein of unknown function
CIW71_RS08440	COG0312	modulator of DNA gyrase
CIW71_RS08445	COG3028	Belongs to the UPF0307 family
CIW71_RS08450	COG0312	modulator of DNA gyrase
CIW71_RS08460	COG4104	PAAR repeat-containing protein
CIW71_RS08470	COG0142	geranyltranstransferase activity
CIW71_RS08475	COG1722	exodeoxyribonuclease VII activity
CIW71_RS08480	COG0037	tRNA processing
CIW71_RS08490	COG1785	Belongs to the alkaline phosphatase family
CIW71_RS08495	COG1301	dicarboxylic acid transport
CIW71_RS08500	COG4106	trans-aconitate 2-methyltransferase activity
CIW71_RS08510	COG0791	NLP P60 protein
CIW71_RS08515	COG0791	NLP P60 protein
CIW71_RS08520	COG1047	Peptidyl-prolyl cis-trans
CIW71_RS08525	COG2311	Membrane
CIW71_RS08530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIW71_RS08535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CIW71_RS08555	COG3590	peptidase
CIW71_RS08565	COG3590	peptidase
CIW71_RS08585	COG0489	protein tyrosine kinase activity
CIW71_RS08595	COG0717	Belongs to the dCTP deaminase family
CIW71_RS08640	COG1404	Belongs to the peptidase S8 family
CIW71_RS08645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CIW71_RS08655	COG2336	PFAM SpoVT AbrB
CIW71_RS08665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIW71_RS08670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CIW71_RS08690	COG0494	nUDIX hydrolase
CIW71_RS08715	COG0688	phosphatidylethanolamine metabolic process
CIW71_RS08725	COG2890	protein-(glutamine-N5) methyltransferase activity
CIW71_RS08730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CIW71_RS08735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CIW71_RS08740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CIW71_RS08760	COG0101	tRNA pseudouridine synthase activity
CIW71_RS08765	COG0135	phosphoribosylanthranilate isomerase activity
CIW71_RS08775	COG0133	tryptophan synthase activity
CIW71_RS08785	COG0159	tryptophan synthase activity
CIW71_RS08790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CIW71_RS08795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIW71_RS08825	COG0300	oxidoreductase activity
CIW71_RS08830	COG0149	triose-phosphate isomerase activity
CIW71_RS08845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW71_RS08850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW71_RS08855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW71_RS08860	COG0649	NAD binding
CIW71_RS08865	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CIW71_RS08870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CIW71_RS08880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CIW71_RS08885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW71_RS08910	COG1007	ATP synthesis coupled electron transport
CIW71_RS08920	COG0779	Required for maturation of 30S ribosomal subunits
CIW71_RS08925	COG0195	Participates in both transcription termination and antitermination
CIW71_RS08930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CIW71_RS08935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CIW71_RS08940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CIW71_RS08945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CIW71_RS08950	COG1185	polyribonucleotide nucleotidyltransferase activity
CIW71_RS08985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CIW71_RS08995	COG2095	MarC family integral membrane protein
CIW71_RS09010	COG1611	Belongs to the LOG family
CIW71_RS09055	COG0556	nucleotide-excision repair
CIW71_RS09070	COG3505	Type IV secretory pathway VirD4
CIW71_RS09090	COG2948	multi-organism process
CIW71_RS09110	COG3702	type iv secretory pathway
CIW71_RS09180	COG1082	Xylose isomerase domain protein TIM barrel
CIW71_RS09205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CIW71_RS09210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CIW71_RS09225	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CIW71_RS09230	COG0072	phenylalanine-tRNA ligase activity
CIW71_RS09230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIW71_RS09280	COG0438	transferase activity, transferring glycosyl groups
CIW71_RS09285	COG0438	transferase activity, transferring glycosyl groups
CIW71_RS09295	COG0438	transferase activity, transferring glycosyl groups
CIW71_RS09320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIW71_RS09325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIW71_RS09330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIW71_RS09350	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CIW71_RS09360	COG1960	acyl-CoA dehydrogenase activity
CIW71_RS09375	COG3040	lipid binding
CIW71_RS09390	COG0322	excinuclease ABC activity
CIW71_RS09410	COG4191	Histidine kinase
CIW71_RS09410	COG0784	Response regulator, receiver
CIW71_RS09415	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CIW71_RS09420	COG1194	a g-specific adenine glycosylase
CIW71_RS09430	COG0552	protein localization to endoplasmic reticulum
CIW71_RS09440	COG3938	Belongs to the proline racemase family
CIW71_RS09445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIW71_RS09460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CIW71_RS09470	COG0006	proline dipeptidase activity
CIW71_RS09485	COG0531	amino acid
CIW71_RS09550	COG4206	TonB-dependent receptor
CIW71_RS09585	COG0326	Molecular chaperone. Has ATPase activity
CIW71_RS09590	COG0742	ribosomal rna small subunit methyltransferase
CIW71_RS09595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CIW71_RS09610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CIW71_RS09615	COG0405	Gamma-glutamyltransferase
CIW71_RS09620	COG3291	Pkd domain containing protein
CIW71_RS09625	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CIW71_RS09675	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CIW71_RS09680	COG0343	queuine tRNA-ribosyltransferase activity
CIW71_RS09685	COG1862	Preprotein translocase
CIW71_RS09695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CIW71_RS09755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CIW71_RS09755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CIW71_RS09760	COG1105	Belongs to the carbohydrate kinase PfkB family
CIW71_RS09765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CIW71_RS09765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIW71_RS09770	COG1609	Transcriptional regulator
CIW71_RS09775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIW71_RS09780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW71_RS09790	COG2902	Dehydrogenase
CIW71_RS09805	COG0477	Major facilitator Superfamily
CIW71_RS09815	COG0784	Response regulator, receiver
CIW71_RS09815	COG2205	protein histidine kinase activity
CIW71_RS09815	COG5002	protein histidine kinase activity
CIW71_RS09820	COG2733	membrane
CIW71_RS09830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CIW71_RS09845	COG2223	nitrite transmembrane transporter activity
CIW71_RS09850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CIW71_RS09855	COG0243	molybdopterin cofactor binding
CIW71_RS09865	COG0477	Major facilitator Superfamily
CIW71_RS09870	COG2703	oxygen carrier activity
CIW71_RS09880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIW71_RS09885	COG0174	glutamine synthetase
CIW71_RS09890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CIW71_RS09905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CIW71_RS09925	COG3842	ATPase activity
CIW71_RS09930	COG1176	ABC-type spermidine putrescine transport system, permease component I
CIW71_RS09935	COG1177	transmembrane transport
CIW71_RS09940	COG1012	belongs to the aldehyde dehydrogenase family
CIW71_RS09955	COG4535	Mg2 and Co2 transporter CorC
CIW71_RS09965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CIW71_RS09975	COG1702	phosphate starvation-inducible protein PhoH
CIW71_RS09980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIW71_RS09995	COG0741	lytic transglycosylase activity
CIW71_RS10005	COG0723	plastoquinol--plastocyanin reductase activity
CIW71_RS10010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CIW71_RS10015	COG2857	Cytochrome c1
CIW71_RS10020	COG0625	glutathione transferase activity
CIW71_RS10025	COG2969	positive regulation of protein catabolic process
CIW71_RS10045	COG1201	RNA secondary structure unwinding
CIW71_RS10050	COG2094	Belongs to the DNA glycosylase MPG family
CIW71_RS10055	COG0840	transmembrane signaling receptor activity
CIW71_RS10060	COG0835	chemotaxis
CIW71_RS10200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CIW71_RS10210	COG1570	exodeoxyribonuclease VII activity
CIW71_RS10215	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CIW71_RS10220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CIW71_RS10220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CIW71_RS10225	COG0802	atpase or kinase
CIW71_RS10230	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIW71_RS10235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CIW71_RS10260	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS10265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIW71_RS10270	COG0501	Belongs to the peptidase M48B family
CIW71_RS10280	COG2081	HI0933 family
CIW71_RS10285	COG4681	YaeQ
CIW71_RS10295	COG0625	glutathione transferase activity
CIW71_RS10305	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CIW71_RS10310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CIW71_RS10315	COG0513	Belongs to the DEAD box helicase family
CIW71_RS10320	COG0488	(ABC) transporter
CIW71_RS10340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CIW71_RS10345	COG0483	inositol monophosphate 1-phosphatase activity
CIW71_RS10360	COG3300	MHYT domain
CIW71_RS10360	COG5001	Diguanylate cyclase
CIW71_RS10365	COG1509	lysine 2,3-aminomutase activity
CIW71_RS10370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CIW71_RS10380	COG0402	S-adenosylhomocysteine deaminase activity
CIW71_RS10385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CIW71_RS10450	COG4302	ethanolamine ammonia-lyase activity
CIW71_RS10480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CIW71_RS10485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CIW71_RS10500	COG2166	iron-sulfur cluster assembly
CIW71_RS10505	COG0215	cysteine-tRNA ligase activity
CIW71_RS10515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CIW71_RS10520	COG0137	argininosuccinate synthase activity
CIW71_RS10530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CIW71_RS10535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CIW71_RS10545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CIW71_RS10550	COG0165	Argininosuccinate lyase
CIW71_RS10560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CIW71_RS10565	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CIW71_RS10595	COG1294	oxidase, subunit
CIW71_RS10605	COG4988	ABC transporter
CIW71_RS10610	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CIW71_RS10615	COG1278	Cold shock
CIW71_RS10620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CIW71_RS10640	COG1138	Cytochrome C-type biogenesis protein
CIW71_RS10645	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CIW71_RS10665	COG4133	protoheme IX ABC transporter activity
CIW71_RS10670	COG0436	Aminotransferase
CIW71_RS10690	COG1187	pseudouridine synthase activity
CIW71_RS10695	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CIW71_RS10700	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CIW71_RS10705	COG2350	Protein conserved in bacteria
CIW71_RS10735	COG1175	transmembrane transport
CIW71_RS10740	COG0395	ABC-type sugar transport system, permease component
CIW71_RS10765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIW71_RS10770	COG2957	Belongs to the agmatine deiminase family
CIW71_RS10790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CIW71_RS10795	COG0539	negative regulation of cytoplasmic translation
CIW71_RS10800	COG0776	regulation of translation
CIW71_RS10810	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CIW71_RS10815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIW71_RS10825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CIW71_RS10830	COG0475	glutathione-regulated potassium exporter activity
CIW71_RS10830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CIW71_RS10840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CIW71_RS10850	COG0519	Catalyzes the synthesis of GMP from XMP
CIW71_RS10850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CIW71_RS10855	COG0582	viral genome integration into host DNA
CIW71_RS10905	COG0667	Aldo Keto reductase
CIW71_RS10950	COG3451	type IV secretory pathway VirB4
CIW71_RS10965	COG3846	protein secretion by the type IV secretion system
CIW71_RS10990	COG3002	Belongs to the UPF0753 family
CIW71_RS10995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CIW71_RS11000	COG0583	DNA-binding transcription factor activity
CIW71_RS11020	COG2197	response regulator
CIW71_RS11035	COG1335	isochorismatase
CIW71_RS11045	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CIW71_RS11060	COG1914	H( )-stimulated, divalent metal cation uptake system
CIW71_RS11080	COG2814	Major facilitator Superfamily
CIW71_RS11090	COG0668	transmembrane transport
CIW71_RS11100	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CIW71_RS11115	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS11120	COG1183	phosphatidylcholine synthase activity
CIW71_RS11130	COG3243	poly(R)-hydroxyalkanoic acid synthase
CIW71_RS11145	COG0723	plastoquinol--plastocyanin reductase activity
CIW71_RS11145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIW71_RS11155	COG2183	response to ionizing radiation
CIW71_RS11165	COG2205	protein histidine kinase activity
CIW71_RS11165	COG0784	Response regulator, receiver
CIW71_RS11250	COG0800	Aldolase
CIW71_RS11255	COG0129	dihydroxy-acid dehydratase activity
CIW71_RS11260	COG0363	glucosamine-6-phosphate deaminase activity
CIW71_RS11265	COG0837	glucose binding
CIW71_RS11270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CIW71_RS11295	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CIW71_RS11310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CIW71_RS11315	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CIW71_RS11325	COG4591	ABC-type transport system involved in lipoprotein release permease component
CIW71_RS11330	COG1136	(ABC) transporter
CIW71_RS11345	COG0811	peptide transport
CIW71_RS11355	COG1132	(ABC) transporter
CIW71_RS11360	COG1663	tetraacyldisaccharide 4'-kinase activity
CIW71_RS11365	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CIW71_RS11370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CIW71_RS11380	COG0322	excinuclease ABC activity
CIW71_RS11385	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CIW71_RS11405	COG0582	viral genome integration into host DNA
CIW71_RS11430	COG0583	DNA-binding transcription factor activity
CIW71_RS11470	COG3593	DNA synthesis involved in DNA repair
CIW71_RS11605	COG2814	Major facilitator Superfamily
CIW71_RS11615	COG2816	NAD+ diphosphatase activity
CIW71_RS11635	COG1960	acyl-CoA dehydrogenase activity
CIW71_RS11650	COG0477	Major facilitator Superfamily
CIW71_RS11655	COG0583	DNA-binding transcription factor activity
CIW71_RS11865	COG0270	DNA (cytosine-5-)-methyltransferase activity
CIW71_RS11885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIW71_RS11895	COG0629	single-stranded DNA binding
CIW71_RS12050	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CIW71_RS12070	COG1054	Belongs to the UPF0176 family
CIW71_RS12080	COG1530	ribonuclease E activity
CIW71_RS12090	COG3064	Membrane
CIW71_RS12095	COG0428	transporter
CIW71_RS12105	COG2154	pterin-4-alpha-carbinolamine dehydratase
CIW71_RS12110	COG0316	Belongs to the HesB IscA family
CIW71_RS12110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CIW71_RS12315	COG1238	metal cluster binding
CIW71_RS12350	COG3279	Response regulator of the LytR AlgR family
CIW71_RS12375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW71_RS12395	COG4566	intracellular signal transduction
CIW71_RS12430	COG3685	Protein conserved in bacteria
CIW71_RS12455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CIW71_RS12455	COG1648	precorrin-2 dehydrogenase activity
CIW71_RS12465	COG0746	molybdenum cofactor guanylyltransferase activity
CIW71_RS12470	COG0303	'Molybdopterin
CIW71_RS12480	COG0708	Exodeoxyribonuclease III
CIW71_RS12615	COG4644	lycopene metabolic process
CIW71_RS12655	COG4456	Virulence-associated protein
CIW71_RS12670	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CIW71_RS12840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CIW71_RS12845	COG0303	'Molybdopterin
CIW71_RS12850	COG1160	GTP binding
CIW71_RS12855	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CIW71_RS12865	COG1426	Protein conserved in bacteria
CIW71_RS12875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CIW71_RS12890	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIW71_RS12890	COG1024	Enoyl-CoA hydratase
CIW71_RS12895	COG0183	Belongs to the thiolase family
CIW71_RS12905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CIW71_RS12910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CIW71_RS12920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CIW71_RS12930	COG1674	ftsk spoiiie
CIW71_RS12935	COG0492	ferredoxin-NADP+ reductase activity
CIW71_RS12945	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CIW71_RS12955	COG0542	response to heat
CIW71_RS12970	COG0482	sulfurtransferase activity
CIW71_RS12975	COG2915	High frequency lysogenization protein hflD homolog
CIW71_RS13005	COG5002	protein histidine kinase activity
CIW71_RS13025	COG0784	Response regulator, receiver
CIW71_RS13025	COG0835	chemotaxis
CIW71_RS13035	COG1558	bacterial-type flagellum-dependent cell motility
CIW71_RS13040	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CIW71_RS13050	COG4787	bacterial-type flagellum-dependent cell motility
CIW71_RS13070	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CIW71_RS13075	COG1706	bacterial-type flagellum-dependent cell motility
CIW71_RS13080	COG3951	Flagellar rod assembly protein muramidase FlgJ
CIW71_RS13080	COG1705	Flagellar rod assembly protein muramidase FlgJ
CIW71_RS13090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CIW71_RS13095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CIW71_RS13100	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CIW71_RS13130	COG2201	protein-glutamate methylesterase activity
CIW71_RS13150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIW71_RS13155	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS13205	COG1677	Flagellar hook-basal body complex protein FliE
CIW71_RS13255	COG3190	flagellar
CIW71_RS13270	COG1684	flagellar biosynthetic protein fliR
CIW71_RS13300	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CIW71_RS13330	COG0643	Histidine kinase
CIW71_RS13330	COG2198	Histidine kinase
CIW71_RS13330	COG0784	Response regulator, receiver
CIW71_RS13405	COG1192	Involved in chromosome partitioning
CIW71_RS13425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CIW71_RS13430	COG1360	Flagellar Motor Protein
CIW71_RS13440	COG0835	chemotaxis
CIW71_RS13450	COG0745	RESPONSE REGULATOR receiver
CIW71_RS13460	COG0840	transmembrane signaling receptor activity
CIW71_RS13475	COG0840	transmembrane signaling receptor activity
CIW71_RS13490	COG0840	transmembrane signaling receptor activity
CIW71_RS13495	COG0840	transmembrane signaling receptor activity
CIW71_RS13500	COG0840	transmembrane signaling receptor activity
CIW71_RS13515	COG0840	transmembrane signaling receptor activity
CIW71_RS13520	COG0840	transmembrane signaling receptor activity
CIW71_RS13525	COG0840	transmembrane signaling receptor activity
CIW71_RS13530	COG0840	transmembrane signaling receptor activity
CIW71_RS13550	COG0835	chemotaxis
CIW71_RS13560	COG0840	transmembrane signaling receptor activity
CIW71_RS13570	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CIW71_RS13575	COG2201	protein-glutamate methylesterase activity
CIW71_RS13585	COG2267	carboxylic ester hydrolase activity
CIW71_RS13615	COG0318	PFAM AMP-dependent synthetase and ligase
CIW71_RS13620	COG1024	Enoyl-CoA hydratase
CIW71_RS13625	COG2205	protein histidine kinase activity
CIW71_RS13625	COG2198	Histidine kinase
CIW71_RS13625	COG0784	Response regulator, receiver
CIW71_RS13640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CIW71_RS13645	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CIW71_RS13650	COG3279	Response regulator of the LytR AlgR family
CIW71_RS13685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CIW71_RS13695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CIW71_RS13700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CIW71_RS13710	COG0505	Belongs to the CarA family
CIW71_RS13715	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CIW71_RS13720	COG2258	MOSC domain
CIW71_RS13725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIW71_RS13770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CIW71_RS13790	COG0277	FAD linked oxidase domain protein
CIW71_RS13795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CIW71_RS13805	COG0531	amino acid
CIW71_RS13810	COG0531	amino acid
CIW71_RS13815	COG0235	Class ii aldolase
CIW71_RS13820	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CIW71_RS13825	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CIW71_RS13840	COG0140	phosphoribosyl-ATP diphosphatase activity
CIW71_RS13840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CIW71_RS13845	COG0107	imidazoleglycerol-phosphate synthase activity
CIW71_RS13850	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CIW71_RS13855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CIW71_RS13860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CIW71_RS13860	COG0131	Imidazoleglycerol-phosphate dehydratase
CIW71_RS13865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CIW71_RS13870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CIW71_RS13875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CIW71_RS13885	COG0124	histidyl-tRNA synthetase
CIW71_RS13890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CIW71_RS13900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CIW71_RS13950	COG1649	PFAM Uncharacterised BCR, COG1649
CIW71_RS13950	COG0726	polysaccharide deacetylase
CIW71_RS13955	COG1215	transferase activity, transferring glycosyl groups
CIW71_RS13970	COG1012	belongs to the aldehyde dehydrogenase family
CIW71_RS13990	COG0167	dihydroorotate dehydrogenase activity
CIW71_RS13995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CIW71_RS14000	COG0697	spore germination
CIW71_RS14010	COG1794	racemase activity, acting on amino acids and derivatives
CIW71_RS14025	COG0671	phosphoesterase, PA-phosphatase related
CIW71_RS14030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CIW71_RS14045	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CIW71_RS14050	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CIW71_RS14060	COG4251	negative regulation of phosphorylation
CIW71_RS14060	COG5001	Diguanylate cyclase
CIW71_RS14060	COG2203	Gaf domain
CIW71_RS14060	COG3706	GGDEF domain
CIW71_RS14075	COG1472	Belongs to the glycosyl hydrolase 3 family
CIW71_RS14100	COG0166	Belongs to the GPI family
CIW71_RS14105	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CIW71_RS14110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CIW71_RS14115	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CIW71_RS14135	COG1469	GTP cyclohydrolase I activity
CIW71_RS14140	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIW71_RS14160	COG0477	Major facilitator Superfamily
CIW71_RS14165	COG2115	Belongs to the xylose isomerase family
CIW71_RS14170	COG1070	Carbohydrate kinase
CIW71_RS14180	COG1501	Belongs to the glycosyl hydrolase 31 family
CIW71_RS14220	COG0800	Aldolase
CIW71_RS14225	COG4948	Mandelate Racemase Muconate Lactonizing
CIW71_RS14235	COG3734	2-keto-3-deoxy-galactonokinase
CIW71_RS14240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CIW71_RS14250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CIW71_RS14265	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CIW71_RS14270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CIW71_RS14285	COG0351	phosphomethylpyrimidine kinase
CIW71_RS14310	COG0583	DNA-binding transcription factor activity
CIW71_RS14315	COG1741	Belongs to the pirin family
CIW71_RS14335	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CIW71_RS14340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CIW71_RS14345	COG2137	regulation of response to DNA damage stimulus
CIW71_RS14355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CIW71_RS14360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CIW71_RS14370	COG1546	Belongs to the CinA family
CIW71_RS14375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CIW71_RS14385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CIW71_RS14390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CIW71_RS14400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CIW71_RS14405	COG1534	Rna-binding protein
CIW71_RS14420	COG1238	metal cluster binding
CIW71_RS14425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CIW71_RS14430	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CIW71_RS14440	COG0585	pseudouridine synthase activity
CIW71_RS14445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CIW71_RS14450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CIW71_RS14455	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CIW71_RS14460	COG0148	phosphopyruvate hydratase activity
CIW71_RS14470	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CIW71_RS14475	COG0504	CTP synthase activity
CIW71_RS14500	COG0306	phosphate transporter
CIW71_RS14515	COG1253	flavin adenine dinucleotide binding
CIW71_RS14530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIW71_RS14535	COG0477	Major facilitator Superfamily
CIW71_RS14540	COG1132	(ABC) transporter
CIW71_RS14545	COG1136	(ABC) transporter
CIW71_RS14570	COG2264	protein methyltransferase activity
CIW71_RS14605	COG2244	polysaccharide biosynthetic process
CIW71_RS14685	COG2951	lytic endotransglycosylase activity
CIW71_RS14725	COG1595	DNA-templated transcription, initiation
CIW71_RS14740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CIW71_RS14750	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CIW71_RS14760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIW71_RS14775	COG0784	Response regulator, receiver
CIW71_RS14775	COG4191	Histidine kinase
CIW71_RS14815	COG0840	transmembrane signaling receptor activity
CIW71_RS14830	COG0583	DNA-binding transcription factor activity
CIW71_RS14835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CIW71_RS14840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CIW71_RS14855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CIW71_RS14860	COG0077	Prephenate dehydratase
CIW71_RS14860	COG1605	Chorismate mutase
CIW71_RS14865	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CIW71_RS14870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CIW71_RS14875	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CIW71_RS14915	COG1228	amidohydrolase
CIW71_RS14920	COG2986	histidine ammonia-lyase
CIW71_RS14930	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CIW71_RS14945	COG4993	Dehydrogenase
CIW71_RS14955	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CIW71_RS14970	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CIW71_RS14975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CIW71_RS14980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CIW71_RS14995	COG3115	cell septum assembly
CIW71_RS15005	COG0359	binds to the 23S rRNA
CIW71_RS15010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CIW71_RS15015	COG0360	Binds together with S18 to 16S ribosomal RNA
CIW71_RS15020	COG0316	Belongs to the HesB IscA family
CIW71_RS15030	COG0017	Asparaginyl-tRNA synthetase
CIW71_RS15050	COG2808	Putative FMN-binding domain
CIW71_RS15120	COG0288	reversible hydration of carbon dioxide
CIW71_RS15125	COG0662	Cupin 2, conserved barrel domain protein
CIW71_RS15135	COG3844	kynureninase activity
CIW71_RS15140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CIW71_RS15145	COG2925	Exonuclease
CIW71_RS15170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CIW71_RS15175	COG0116	Belongs to the methyltransferase superfamily
CIW71_RS15175	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CIW71_RS15185	COG0488	(ABC) transporter
CIW71_RS15220	COG0494	nUDIX hydrolase
CIW71_RS15230	COG1024	Enoyl-CoA hydratase
CIW71_RS15240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CIW71_RS15245	COG0659	secondary active sulfate transmembrane transporter activity
CIW71_RS15270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CIW71_RS15275	COG0573	inorganic phosphate transmembrane transporter activity
CIW71_RS15280	COG0581	inorganic phosphate transmembrane transporter activity
CIW71_RS15285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CIW71_RS15290	COG0704	Plays a role in the regulation of phosphate uptake
CIW71_RS15300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CIW71_RS15310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CIW71_RS15320	COG0557	exoribonuclease II activity
CIW71_RS15340	COG1960	acyl-CoA dehydrogenase activity
CIW71_RS15345	COG1960	acyl-CoA dehydrogenase activity
CIW71_RS15360	COG1960	acyl-CoA dehydrogenase activity
CIW71_RS15365	COG2226	methyltransferase
CIW71_RS15370	COG1410	methionine synthase
CIW71_RS15370	COG0646	methionine synthase
CIW71_RS15375	COG0646	methionine synthase
CIW71_RS15375	COG1410	methionine synthase
CIW71_RS15385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIW71_RS15410	COG2900	Belongs to the SlyX family
CIW71_RS15425	COG0386	Belongs to the glutathione peroxidase family
CIW71_RS15435	COG1725	Transcriptional regulator
CIW71_RS15440	COG1131	(ABC) transporter
CIW71_RS15470	COG1253	flavin adenine dinucleotide binding
CIW71_RS15490	COG2850	peptidyl-arginine hydroxylation
CIW71_RS15525	COG1132	(ABC) transporter
CIW71_RS15530	COG0583	DNA-binding transcription factor activity
CIW71_RS15570	COG0484	heat shock protein binding
CIW71_RS15575	COG0443	Heat shock 70 kDa protein
CIW71_RS15580	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CIW71_RS15585	COG1420	regulation of RNA biosynthetic process
CIW71_RS15590	COG0497	DNA recombination
CIW71_RS15600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CIW71_RS15615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CIW71_RS15675	COG3706	GGDEF domain
CIW71_RS15720	COG0583	DNA-binding transcription factor activity
CIW71_RS15735	COG0415	Belongs to the DNA photolyase family
CIW71_RS15740	COG0305	Participates in initiation and elongation during chromosome replication
CIW71_RS15750	COG0367	asparagine synthase
CIW71_RS15770	COG1960	acyl-CoA dehydrogenase activity
CIW71_RS15785	COG0084	hydrolase, TatD family'
CIW71_RS15790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CIW71_RS15855	COG0386	Belongs to the glutathione peroxidase family
CIW71_RS15865	COG0339	signal peptide processing
CIW71_RS15915	COG2814	Major facilitator Superfamily
CIW71_RS15920	COG1566	PFAM secretion protein HlyD family protein
CIW71_RS15945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CIW71_RS15965	COG4774	siderophore transport
CIW71_RS15975	COG0367	asparagine synthase
CIW71_RS15980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CIW71_RS15985	COG1393	Belongs to the ArsC family
CIW71_RS15995	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CIW71_RS16035	COG0052	Belongs to the universal ribosomal protein uS2 family
CIW71_RS16040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CIW71_RS16050	COG0528	UMP kinase activity
CIW71_RS16055	COG0233	cytoplasmic translational termination
CIW71_RS16060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CIW71_RS16065	COG0575	Belongs to the CDS family
CIW71_RS16070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CIW71_RS16075	COG0750	zinc metalloprotease
CIW71_RS16090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIW71_RS16095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CIW71_RS16100	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIW71_RS16105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIW71_RS16110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CIW71_RS16120	COG0825	malonyl-CoA metabolic process
CIW71_RS16135	COG1981	membrane
CIW71_RS16155	COG1695	Transcriptional regulator
CIW71_RS16175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CIW71_RS16185	COG2040	homocysteine
CIW71_RS16190	COG0833	amino acid
CIW71_RS16195	COG0346	lactoylglutathione lyase activity
CIW71_RS16200	COG1131	(ABC) transporter
CIW71_RS16215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIW71_RS16215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIW71_RS16225	COG2878	Part of a membrane complex involved in electron transport
CIW71_RS16240	COG1595	DNA-templated transcription, initiation
CIW71_RS16265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CIW71_RS16280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CIW71_RS16285	COG0251	oxidation-reduction process
CIW71_RS16295	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CIW71_RS16295	COG0392	lysyltransferase activity
CIW71_RS16330	COG2814	Major facilitator Superfamily
CIW71_RS16340	COG2824	Alkylphosphonate utilization operon protein PhnA
CIW71_RS16350	COG1047	Peptidyl-prolyl cis-trans
CIW71_RS16355	COG1077	Cell shape determining protein MreB Mrl
CIW71_RS16370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CIW71_RS16380	COG5487	UPF0391 membrane protein
CIW71_RS16385	COG1451	nucleotide metabolic process
CIW71_RS16410	COG0183	Belongs to the thiolase family
CIW71_RS16445	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CIW71_RS16445	COG1793	dna ligase
CIW71_RS16455	COG1793	dna ligase
CIW71_RS16460	COG1201	RNA secondary structure unwinding
CIW71_RS16470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CIW71_RS16475	COG1278	Cold shock
CIW71_RS16480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CIW71_RS16485	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CIW71_RS16490	COG1472	Belongs to the glycosyl hydrolase 3 family
CIW71_RS16495	COG3046	protein related to deoxyribodipyrimidine photolyase
CIW71_RS16500	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CIW71_RS16505	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CIW71_RS16515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CIW71_RS16525	COG1381	Involved in DNA repair and RecF pathway recombination
CIW71_RS16530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CIW71_RS16535	COG0571	ribonuclease III activity
CIW71_RS16550	COG0481	GTPase activity
CIW71_RS16555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CIW71_RS16570	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIW71_RS16570	COG1024	Enoyl-CoA hydratase
CIW71_RS16595	COG1960	acyl-CoA dehydrogenase activity
CIW71_RS16615	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CIW71_RS16620	COG3250	beta-galactosidase activity
CIW71_RS16665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CIW71_RS16675	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CIW71_RS16695	COG0534	Mate efflux family protein
CIW71_RS16700	COG0335	large ribosomal subunit rRNA binding
CIW71_RS16705	COG0336	Belongs to the RNA methyltransferase TrmD family
CIW71_RS16710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CIW71_RS16715	COG0228	four-way junction DNA binding
CIW71_RS16720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CIW71_RS16730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CIW71_RS16740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CIW71_RS16770	COG4191	Histidine kinase
CIW71_RS16770	COG0784	Response regulator, receiver
CIW71_RS16775	COG3437	response regulator, receiver
CIW71_RS16775	COG2205	protein histidine kinase activity
CIW71_RS16775	COG4999	Histidine kinase
CIW71_RS16775	COG3850	Histidine kinase
CIW71_RS16780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CIW71_RS16795	COG5507	3-demethylubiquinone-9 3-methyltransferase
CIW71_RS16805	COG4771	TonB-dependent receptor
CIW71_RS16830	COG2172	sigma factor antagonist activity
CIW71_RS16835	COG1366	Belongs to the anti-sigma-factor antagonist family
CIW71_RS16840	COG1366	Belongs to the anti-sigma-factor antagonist family
CIW71_RS16855	COG0326	Molecular chaperone. Has ATPase activity
CIW71_RS16860	COG2207	Transcriptional regulator
CIW71_RS16870	COG3152	Membrane
CIW71_RS16885	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CIW71_RS16890	COG1845	cytochrome c oxidase, subunit III
CIW71_RS16895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CIW71_RS16930	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CIW71_RS16930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW71_RS17030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CIW71_RS17035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CIW71_RS17040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CIW71_RS17045	COG0196	riboflavin kinase activity
CIW71_RS17050	COG0728	peptidoglycan biosynthetic process
CIW71_RS17055	COG0268	Binds directly to 16S ribosomal RNA
CIW71_RS17060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CIW71_RS17065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CIW71_RS17070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CIW71_RS17075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CIW71_RS17080	COG0824	Thioesterase
CIW71_RS17095	COG1946	Acyl-CoA thioesterase
CIW71_RS17120	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CIW71_RS17130	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CIW71_RS17165	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CIW71_RS17180	COG2197	response regulator
CIW71_RS17185	COG4585	Histidine kinase
CIW71_RS17200	COG0850	regulation of cytokinetic process
CIW71_RS17205	COG2894	cell division
CIW71_RS17210	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CIW71_RS17220	COG0642	Histidine kinase
CIW71_RS17225	COG0745	RESPONSE REGULATOR receiver
CIW71_RS17240	COG2194	sulfuric ester hydrolase activity
CIW71_RS17255	COG2814	Major facilitator Superfamily
CIW71_RS17260	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CIW71_RS17260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CIW71_RS17270	COG0656	L-ascorbic acid biosynthetic process
CIW71_RS17275	COG0753	catalase activity
CIW71_RS17310	COG2207	Transcriptional regulator
CIW71_RS17310	COG1917	Cupin 2, conserved barrel domain protein
CIW71_RS17340	COG1506	peptidase
CIW71_RS17340	COG0823	Involved in the tonB-independent uptake of proteins
CIW71_RS17355	COG1297	OPT oligopeptide transporter protein
CIW71_RS17375	COG0587	DNA-directed DNA polymerase activity
CIW71_RS17390	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CIW71_RS17425	COG2080	2 iron, 2 sulfur cluster binding
CIW71_RS17430	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CIW71_RS17435	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CIW71_RS17460	COG0492	ferredoxin-NADP+ reductase activity
CIW71_RS17470	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS17475	COG3537	Alpha-1,2-mannosidase
CIW71_RS17485	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS17505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CIW71_RS17515	COG1309	transcriptional regulator
CIW71_RS17535	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CIW71_RS17545	COG1196	nuclear chromosome segregation
CIW71_RS17550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CIW71_RS17590	COG1309	transcriptional regulator
CIW71_RS17595	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS17605	COG0308	aminopeptidase N
CIW71_RS17610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CIW71_RS17620	COG0330	HflC and HflK could
CIW71_RS17625	COG0330	HflC and HflK could
CIW71_RS17645	COG0678	peroxiredoxin activity
CIW71_RS17655	COG4953	penicillin-binding protein 1C
CIW71_RS17670	COG2373	Large extracellular alpha-helical protein
CIW71_RS17720	COG3829	transcription factor binding
CIW71_RS17745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CIW71_RS17750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CIW71_RS17765	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS17780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIW71_RS17785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CIW71_RS17790	COG1399	metal-binding, possibly nucleic acid-binding protein
CIW71_RS17795	COG0424	maF-like protein
CIW71_RS17815	COG0714	Associated with various cellular activities
CIW71_RS17835	COG0537	adenosine 5'-monophosphoramidase activity
CIW71_RS17840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CIW71_RS17845	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CIW71_RS17850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CIW71_RS17985	COG0314	molybdopterin synthase activity
CIW71_RS17990	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CIW71_RS17995	COG0315	cyclic pyranopterin monophosphate synthase activity
CIW71_RS18000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CIW71_RS18005	COG1234	tRNA 3'-trailer cleavage
CIW71_RS18010	COG3642	lipopolysaccharide core region biosynthetic process
CIW71_RS18015	COG0859	PFAM glycosyl transferase family 9
CIW71_RS18030	COG0631	protein serine/threonine phosphatase activity
CIW71_RS18035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CIW71_RS18040	COG0328	RNA-DNA hybrid ribonuclease activity
CIW71_RS18050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIW71_RS18060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CIW71_RS18090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CIW71_RS18100	COG0544	peptidyl-prolyl cis-trans isomerase activity
CIW71_RS18110	COG3852	Histidine kinase
CIW71_RS18145	COG0473	3-isopropylmalate dehydrogenase activity
CIW71_RS18160	COG4783	chaperone-mediated protein folding
CIW71_RS18175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CIW71_RS18190	COG0671	phosphoesterase, PA-phosphatase related
CIW71_RS18195	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIW71_RS18205	COG3291	Pkd domain containing protein
CIW71_RS18245	COG0285	dihydrofolate synthase activity
CIW71_RS18250	COG0406	alpha-ribazole phosphatase activity
CIW71_RS18280	COG1063	alcohol dehydrogenase
CIW71_RS18290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CIW71_RS18295	COG4208	sulfate ABC transporter
CIW71_RS18300	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CIW71_RS18305	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CIW71_RS18310	COG0156	8-amino-7-oxononanoate synthase activity
CIW71_RS18340	COG0604	alcohol dehydrogenase
CIW71_RS18345	COG0446	pyridine nucleotide-disulphide oxidoreductase
CIW71_RS18345	COG1902	pentaerythritol trinitrate reductase activity
CIW71_RS18365	COG0625	glutathione transferase activity
CIW71_RS18370	COG0039	L-malate dehydrogenase activity
CIW71_RS18375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CIW71_RS18380	COG1217	gtp-binding protein TYPA
CIW71_RS18400	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CIW71_RS18420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CIW71_RS18425	COG0203	ribosomal protein L17
CIW71_RS18450	COG0201	protein transport
CIW71_RS18455	COG0200	Binds to the 23S rRNA
CIW71_RS18460	COG1841	ribosomal large subunit assembly
CIW71_RS18470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CIW71_RS18475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CIW71_RS18480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CIW71_RS18490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CIW71_RS18495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CIW71_RS18505	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CIW71_RS18510	COG0255	Belongs to the universal ribosomal protein uL29 family
CIW71_RS18515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CIW71_RS18520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CIW71_RS18530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CIW71_RS18535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CIW71_RS18540	COG0089	rRNA binding
CIW71_RS18545	COG0088	Forms part of the polypeptide exit tunnel
CIW71_RS18550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CIW71_RS18555	COG0051	transcription antitermination factor activity, RNA binding
CIW71_RS18560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CIW71_RS18565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CIW71_RS18570	COG0049	tRNA binding
CIW71_RS18575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CIW71_RS18580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CIW71_RS18585	COG0085	RNA polymerase activity
CIW71_RS18590	COG0222	ribosome binding
CIW71_RS18595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CIW71_RS18600	COG0081	regulation of translation
CIW71_RS18605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CIW71_RS18610	COG0250	Participates in transcription elongation, termination and antitermination
CIW71_RS18625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CIW71_RS18645	COG0012	GTP binding
CIW71_RS18650	COG0193	aminoacyl-tRNA hydrolase activity
CIW71_RS18655	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CIW71_RS18660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CIW71_RS18670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CIW71_RS18675	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CIW71_RS18685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CIW71_RS18690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CIW71_RS18700	COG0521	Mo-molybdopterin cofactor biosynthetic process
CIW71_RS18715	COG1254	Belongs to the acylphosphatase family
CIW71_RS18720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIW71_RS18725	COG1295	ribonuclease BN
CIW71_RS18750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CIW71_RS18755	COG1404	Belongs to the peptidase S8 family
CIW71_RS18770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CIW71_RS18785	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CIW71_RS18810	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CIW71_RS18840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIW71_RS18840	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIW71_RS18860	COG2890	protein-(glutamine-N5) methyltransferase activity
CIW71_RS18870	COG3634	alkyl hydroperoxide reductase activity
CIW71_RS18875	COG0583	DNA-binding transcription factor activity
CIW71_RS18885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CIW71_RS18890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CIW71_RS18900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIW71_RS18910	COG2197	response regulator
CIW71_RS18935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIW71_RS18945	COG0697	spore germination
CIW71_RS18985	COG3386	PFAM SMP-30 Gluconolaconase
CIW71_RS19005	COG1024	Enoyl-CoA hydratase
CIW71_RS19015	COG0318	PFAM AMP-dependent synthetase and ligase
CIW71_RS19020	COG0583	DNA-binding transcription factor activity
CIW71_RS19025	COG3384	dioxygenase
CIW71_RS19055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CIW71_RS19060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CIW71_RS19075	COG2096	Adenosyltransferase
CIW71_RS19080	COG0123	including yeast histone deacetylase and acetoin utilization protein
CIW71_RS19095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CIW71_RS19100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CIW71_RS19105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CIW71_RS19110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CIW71_RS19115	COG2967	ApaG domain
CIW71_RS19120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CIW71_RS19140	COG0747	negative chemotaxis
CIW71_RS19165	COG0431	NADPH-dependent FMN reductase
CIW71_RS19170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIW71_RS19180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIW71_RS19185	COG1116	anion transmembrane transporter activity
CIW71_RS19195	COG3829	transcription factor binding
CIW71_RS19210	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CIW71_RS19215	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CIW71_RS19235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CIW71_RS19260	COG4181	ATPase activity
CIW71_RS19270	COG2175	clavaminate synthase activity
CIW71_RS19280	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CIW71_RS19285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIW71_RS19305	COG4771	TonB-dependent receptor
CIW71_RS19315	COG0667	Aldo Keto reductase
CIW71_RS19325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CIW71_RS19330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIW71_RS19340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CIW71_RS19345	COG4106	trans-aconitate 2-methyltransferase activity
CIW71_RS19355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CIW71_RS19395	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CIW71_RS19405	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CIW71_RS19410	COG2226	methyltransferase
CIW71_RS19440	COG0366	Alpha amylase catalytic
CIW71_RS19465	COG0604	alcohol dehydrogenase
CIW71_RS19465	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS19465	COG3321	synthase
CIW71_RS19480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CIW71_RS19490	COG0494	nUDIX hydrolase
CIW71_RS19495	COG0653	protein targeting
CIW71_RS19500	COG0739	heme binding
CIW71_RS19510	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CIW71_RS19525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CIW71_RS19530	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIW71_RS19535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CIW71_RS19540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CIW71_RS19550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIW71_RS19555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CIW71_RS19560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CIW71_RS19570	COG3116	cell division
CIW71_RS19575	COG0275	rRNA processing
CIW71_RS19615	COG0792	nuclease activity
CIW71_RS19620	COG1988	membrane-bound metal-dependent
CIW71_RS19625	COG0277	FAD linked oxidase domain protein
CIW71_RS19640	COG0745	RESPONSE REGULATOR receiver
CIW71_RS19645	COG2205	protein histidine kinase activity
CIW71_RS19660	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CIW71_RS19665	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CIW71_RS19670	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CIW71_RS19695	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CIW71_RS19700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIW71_RS19705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CIW71_RS19730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CIW71_RS19730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CIW71_RS19740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CIW71_RS19745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CIW71_RS19755	COG0488	(ABC) transporter
CIW71_RS19765	COG0697	spore germination
CIW71_RS19775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIW71_RS19790	COG3791	Glutathione-dependent formaldehyde-activating
CIW71_RS19820	COG2205	protein histidine kinase activity
CIW71_RS19845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CIW71_RS19860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CIW71_RS19875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CIW71_RS19880	COG1012	belongs to the aldehyde dehydrogenase family
CIW71_RS19885	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CIW71_RS19890	COG0617	tRNA 3'-terminal CCA addition
CIW71_RS19900	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CIW71_RS19905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CIW71_RS19910	COG1609	Transcriptional regulator
CIW71_RS19920	COG2188	Transcriptional regulator
CIW71_RS19935	COG3250	beta-galactosidase activity
CIW71_RS19965	COG4795	General secretion pathway protein
CIW71_RS19985	COG1459	type II secretion system
CIW71_RS20045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CIW71_RS20050	COG4191	Histidine kinase
CIW71_RS20055	COG0784	Response regulator, receiver
CIW71_RS20060	COG4251	negative regulation of phosphorylation
CIW71_RS20065	COG2823	Periplasmic or secreted lipoprotein
CIW71_RS20070	COG0673	inositol 2-dehydrogenase activity
CIW71_RS20075	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CIW71_RS20110	COG1056	cytidyltransferase-related domain
CIW71_RS20110	COG1051	belongs to the nudix hydrolase family
CIW71_RS20120	COG0583	DNA-binding transcription factor activity
CIW71_RS20135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CIW71_RS20140	COG0321	lipoyl(octanoyl) transferase activity
CIW71_RS20145	COG2921	Belongs to the UPF0250 family
CIW71_RS20155	COG1686	Belongs to the peptidase S11 family
CIW71_RS20165	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CIW71_RS20170	COG2951	lytic endotransglycosylase activity
CIW71_RS20180	COG0772	Belongs to the SEDS family
CIW71_RS20195	COG1792	Involved in formation and maintenance of cell shape
CIW71_RS20200	COG1077	Cell shape determining protein MreB Mrl
CIW71_RS20205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIW71_RS20210	COG3284	Transcriptional regulator
CIW71_RS20220	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CIW71_RS20260	COG0308	aminopeptidase N
CIW71_RS20265	COG3300	MHYT domain
CIW71_RS20265	COG5001	Diguanylate cyclase
CIW71_RS20270	COG2226	methyltransferase
CIW71_RS20295	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CIW71_RS20300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CIW71_RS20305	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CIW71_RS20320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CIW71_RS20330	COG2832	Protein of unknown function (DUF454)
CIW71_RS20340	COG0436	Aminotransferase
CIW71_RS20350	COG1505	serine-type exopeptidase activity
CIW71_RS20380	COG0181	hydroxymethylbilane synthase activity
CIW71_RS20390	COG3275	phosphorelay sensor kinase activity
CIW71_RS20400	COG2943	transferase activity, transferring hexosyl groups
CIW71_RS20425	COG0659	secondary active sulfate transmembrane transporter activity
CIW71_RS20430	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CIW71_RS20430	COG5297	Belongs to the glycosyl hydrolase family 6
CIW71_RS20435	COG0840	transmembrane signaling receptor activity
CIW71_RS20440	COG5001	Diguanylate cyclase
CIW71_RS20490	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CIW71_RS20510	COG1113	amino acid transport
CIW71_RS20525	COG0697	spore germination
CIW71_RS20570	COG0823	Involved in the tonB-independent uptake of proteins
CIW71_RS20570	COG1506	peptidase
CIW71_RS20580	COG2409	Drug exporters of the RND superfamily
CIW71_RS20610	COG0435	Glutathione S-transferase
CIW71_RS20620	COG4221	oxidoreductase activity
CIW71_RS20635	COG4221	oxidoreductase activity
CIW71_RS20720	COG0546	phosphoglycolate phosphatase activity
CIW71_RS20725	COG1802	Transcriptional regulator
CIW71_RS20735	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CIW71_RS20760	COG3052	prosthetic group binding
CIW71_RS20790	COG2353	YceI-like domain
CIW71_RS20795	COG0778	Nitroreductase
CIW71_RS20815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CIW71_RS20820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CIW71_RS20830	COG3386	PFAM SMP-30 Gluconolaconase
CIW71_RS20845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CIW71_RS20860	COG0459	protein refolding
CIW71_RS20875	COG2356	endonuclease I
CIW71_RS20880	COG0300	oxidoreductase activity
CIW71_RS20910	COG1324	tolerance protein
CIW71_RS20920	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CIW71_RS20925	COG0511	ligase activity, forming carbon-carbon bonds
CIW71_RS20935	COG0439	Biotin carboxylase
CIW71_RS20965	COG2264	protein methyltransferase activity
CIW71_RS20990	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CIW71_RS20995	COG4589	Belongs to the CDS family
CIW71_RS21020	COG2453	phosphatase
CIW71_RS21020	COG0671	phosphoesterase, PA-phosphatase related
CIW71_RS21025	COG2267	carboxylic ester hydrolase activity
CIW71_RS21030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CIW71_RS21035	COG0138	bifunctional purine biosynthesis protein purh
CIW71_RS21045	COG0151	Belongs to the GarS family
CIW71_RS21055	COG1289	transmembrane transporter activity
CIW71_RS21060	COG2814	Major facilitator Superfamily
CIW71_RS21070	COG2814	Major facilitator Superfamily
CIW71_RS21090	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CIW71_RS21110	COG0316	Belongs to the HesB IscA family
CIW71_RS21150	COG1051	belongs to the nudix hydrolase family
CIW71_RS21165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CIW71_RS21175	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CIW71_RS21185	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CIW71_RS21190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CIW71_RS21200	COG0134	indole-3-glycerol-phosphate synthase activity
CIW71_RS21205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CIW71_RS21230	COG1597	lipid kinase activity
CIW71_RS21235	COG0456	acetyltransferase
CIW71_RS21250	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CIW71_RS21255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CIW71_RS21275	COG3179	chitinase
CIW71_RS21295	COG2111	Na H antiporter
CIW71_RS21295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CIW71_RS21300	COG1006	Multisubunit Na H antiporter MnhC subunit
CIW71_RS21305	COG0651	ATP synthesis coupled electron transport
CIW71_RS21315	COG2212	antiporter activity
CIW71_RS21320	COG1320	monovalent cation:proton antiporter activity
CIW71_RS21340	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CIW71_RS21345	COG2852	Protein conserved in bacteria
CIW71_RS21365	COG3104	oligopeptide transport
CIW71_RS21370	COG3483	tryptophan 2,3-dioxygenase activity
CIW71_RS21380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CIW71_RS21395	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIW71_RS21400	COG0513	Belongs to the DEAD box helicase family
CIW71_RS21410	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS21415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIW71_RS21450	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS21455	COG0702	epimerase
CIW71_RS21480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CIW71_RS21485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CIW71_RS21490	COG0297	glycogen (starch) synthase activity
CIW71_RS21500	COG2354	Protein conserved in bacteria
CIW71_RS21505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CIW71_RS21515	COG1368	sulfuric ester hydrolase activity
CIW71_RS21520	COG3264	Mechanosensitive ion channel
CIW71_RS21520	COG1511	domain protein
CIW71_RS21590	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CIW71_RS21670	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CIW71_RS21675	COG1040	competence protein
CIW71_RS21680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CIW71_RS21685	COG0156	8-amino-7-oxononanoate synthase activity
CIW71_RS21695	COG2267	carboxylic ester hydrolase activity
CIW71_RS21725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CIW71_RS21735	COG0445	tRNA wobble uridine modification
CIW71_RS21755	COG1414	Transcriptional regulator
CIW71_RS21765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CIW71_RS21770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CIW71_RS21780	COG3485	protocatechuate 3,4-dioxygenase
CIW71_RS21795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CIW71_RS21800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CIW71_RS21825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CIW71_RS21830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CIW71_RS21890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CIW71_RS21905	COG0129	dihydroxy-acid dehydratase activity
CIW71_RS21960	COG1733	regulation of RNA biosynthetic process
CIW71_RS21965	COG0702	epimerase
CIW71_RS22000	COG0583	DNA-binding transcription factor activity
CIW71_RS22005	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CIW71_RS22030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW71_RS22035	COG2205	protein histidine kinase activity
CIW71_RS22040	COG0745	RESPONSE REGULATOR receiver
CIW71_RS22060	COG1902	pentaerythritol trinitrate reductase activity
CIW71_RS22065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CIW71_RS22080	COG2814	Major facilitator Superfamily
CIW71_RS22115	COG0084	hydrolase, TatD family'
CIW71_RS22140	COG2252	PERMEase
CIW71_RS22150	COG1957	nucleoside hydrolase
CIW71_RS22185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CIW71_RS22205	COG2072	flavoprotein involved in K transport
CIW71_RS22210	COG2351	hydroxyisourate hydrolase activity
CIW71_RS22215	COG4807	Protein conserved in bacteria
CIW71_RS22225	COG1643	Atp-dependent helicase
CIW71_RS22240	COG1187	pseudouridine synthase activity
CIW71_RS22255	COG2130	NADP-dependent
CIW71_RS22285	COG1764	response to oxidative stress
CIW71_RS22290	COG1846	Transcriptional regulator
CIW71_RS22295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CIW71_RS22305	COG0697	spore germination
CIW71_RS22370	COG1960	acyl-CoA dehydrogenase activity
CIW71_RS22375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CIW71_RS22380	COG4770	biotin carboxylase activity
CIW71_RS22410	COG2224	Isocitrate lyase
CIW71_RS22415	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CIW71_RS22420	COG0583	DNA-binding transcription factor activity
CIW71_RS22425	COG0475	glutathione-regulated potassium exporter activity
CIW71_RS22455	COG0339	signal peptide processing
CIW71_RS22460	COG1446	asparaginase
CIW71_RS22480	COG0564	pseudouridine synthase activity
CIW71_RS22490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CIW71_RS22500	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIW71_RS22515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIW71_RS22525	COG0318	PFAM AMP-dependent synthetase and ligase
CIW71_RS22530	COG0727	PFAM Uncharacterised protein family (UPF0153)
CIW71_RS22535	COG0596	Alpha beta hydrolase
CIW71_RS22545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIW71_RS22560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CIW71_RS22585	COG2205	protein histidine kinase activity
CIW71_RS22590	COG0028	Belongs to the TPP enzyme family
CIW71_RS22605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CIW71_RS22610	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CIW71_RS22615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIW71_RS22650	COG0183	Belongs to the thiolase family
CIW71_RS22665	COG2032	superoxide dismutase activity
CIW71_RS22670	COG2032	superoxide dismutase activity
CIW71_RS22675	COG2204	response regulator
CIW71_RS22680	COG3852	Histidine kinase
CIW71_RS22685	COG0004	ammonium transporteR
CIW71_RS22690	COG0347	Belongs to the P(II) protein family
CIW71_RS22695	COG0174	glutamine synthetase
CIW71_RS22700	COG1968	undecaprenyl-diphosphatase activity
CIW71_RS22710	COG1881	PFAM PEBP family protein
CIW71_RS22740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW71_RS22750	COG2062	phosphohistidine phosphatase, SixA
CIW71_RS22755	COG0489	protein tyrosine kinase activity
CIW71_RS22780	COG1396	sequence-specific DNA binding
CIW71_RS22800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CIW71_RS22815	COG1125	glycine betaine transport
CIW71_RS22830	COG1119	ATPase activity
CIW71_RS22840	COG1752	Esterase of the alpha-beta hydrolase superfamily
CIW71_RS22850	COG1522	sequence-specific DNA binding
CIW71_RS22855	COG3186	Phenylalanine-4-hydroxylase
CIW71_RS22870	COG2755	lipolytic protein G-D-S-L family
CIW71_RS22880	COG1028	Short-chain dehydrogenase reductase Sdr
CIW71_RS22885	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CIW71_RS22895	COG1609	Transcriptional regulator
CIW71_RS22900	COG3507	Belongs to the glycosyl hydrolase 43 family
CIW71_RS22915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CIW71_RS22925	COG0657	acetylesterase activity
CIW71_RS22925	COG2755	lipolytic protein G-D-S-L family
CIW71_RS22970	COG2911	Protein conserved in bacteria
CIW71_RS22975	COG0729	surface antigen
CIW71_RS22980	COG4771	TonB-dependent receptor
CIW71_RS22985	COG0457	Tetratricopeptide repeat
CIW71_RS22995	COG0752	glycyl-tRNA synthetase alpha subunit
CIW71_RS23000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CIW71_RS23015	COG0519	Catalyzes the synthesis of GMP from XMP
CIW71_RS23015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CIW71_RS23025	COG0805	protein transport
CIW71_RS23030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIW71_RS23035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIW71_RS23045	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CIW71_RS23070	COG2974	May be involved in recombination
CIW71_RS23075	COG0037	tRNA processing
CIW71_RS23085	COG2115	Belongs to the xylose isomerase family
CIW71_RS23095	COG3661	Belongs to the glycosyl hydrolase 67 family
CIW71_RS23105	COG4948	Mandelate Racemase Muconate Lactonizing
CIW71_RS23120	COG0246	Mannitol dehydrogenase
CIW71_RS23170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CIW71_RS23200	COG3386	PFAM SMP-30 Gluconolaconase
CIW71_RS23210	COG3250	beta-galactosidase activity
CIW71_RS23215	COG1904	glucuronate isomerase
CIW71_RS23230	COG3693	PFAM glycoside hydrolase, family 10
CIW71_RS23245	COG2211	Major facilitator Superfamily
CIW71_RS23320	COG2937	Belongs to the GPAT DAPAT family
CIW71_RS23355	COG0284	orotidine-5'-phosphate decarboxylase activity
CIW71_RS23360	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CIW71_RS23370	COG3132	Protein of unknown function, DUF480
CIW71_RS23385	COG0210	DNA helicase
CIW71_RS23390	COG1435	thymidine kinase activity
CIW71_RS23400	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CIW71_RS23410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CIW71_RS23440	COG3135	benzoate transporter
CIW71_RS23460	COG0676	glucose-6-phosphate 1-epimerase activity
CIW71_RS23470	COG3012	SEC-C Motif Domain Protein
CIW71_RS23475	COG0730	response to heat
CIW71_RS23495	COG0302	gtp cyclohydrolase
CIW71_RS23510	COG1566	PFAM secretion protein HlyD family protein
CIW71_RS23520	COG1289	transmembrane transporter activity
CIW71_RS23535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW71_RS23555	COG4691	Plasmid stability protein
CIW71_RS23605	COG0439	Biotin carboxylase
CIW71_RS23650	COG1074	ATP-dependent DNA helicase activity
CIW71_RS23655	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CIW71_RS23670	COG1127	ABC transporter
CIW71_RS23675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CIW71_RS23680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CIW71_RS23695	COG2853	Lipoprotein
CIW71_RS23705	COG0386	Belongs to the glutathione peroxidase family
CIW71_RS23715	COG1322	Protein conserved in bacteria
CIW71_RS23720	COG0604	alcohol dehydrogenase
CIW71_RS23725	COG0583	DNA-binding transcription factor activity
CIW71_RS23740	COG0625	glutathione transferase activity
CIW71_RS23750	COG0531	amino acid
CIW71_RS23755	COG3537	Alpha-1,2-mannosidase
CIW71_RS23770	COG3706	GGDEF domain
CIW71_RS23795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CIW71_RS23805	COG0861	Integral membrane protein TerC family
CIW71_RS23820	COG0584	glycerophosphoryl diester phosphodiesterase
CIW71_RS23835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CIW71_RS23840	COG0726	polysaccharide deacetylase
CIW71_RS23845	COG0706	membrane insertase activity
CIW71_RS23850	COG0594	ribonuclease P activity
CIW71_RS23890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CIW71_RS23905	COG2951	lytic endotransglycosylase activity
CIW71_RS23940	COG4456	Virulence-associated protein
CIW71_RS23980	COG4644	lycopene metabolic process
CIW71_RS24010	COG1192	Involved in chromosome partitioning
CIW71_RS24130	COG1192	Involved in chromosome partitioning
CIW71_RS24270	COG1192	Involved in chromosome partitioning
CIW71_RS24370	COG3504	Conjugal transfer protein
CIW71_RS24375	COG2948	multi-organism process
CIW71_RS24395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW71_RS24455	COG3041	Addiction module toxin RelE StbE family
CIW71_RS24460	COG3077	Addiction module antitoxin, RelB DinJ family
CIW71_RS24480	COG1192	Involved in chromosome partitioning
CIW71_RS24650	COG1609	Transcriptional regulator