locus-tag	class	description
LPY96_RS00175	COG1192	Involved in chromosome partitioning
LPY96_RS00325	COG4644	lycopene metabolic process
LPY96_RS00360	COG4456	Virulence-associated protein
LPY96_RS00380	COG2951	lytic endotransglycosylase activity
LPY96_RS00395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPY96_RS00415	COG3012	SEC-C Motif Domain Protein
LPY96_RS00415	COG3318	Belongs to the UPF0149 family
LPY96_RS00455	COG0489	protein tyrosine kinase activity
LPY96_RS00545	COG3451	type IV secretory pathway VirB4
LPY96_RS00560	COG3846	protein secretion by the type IV secretion system
LPY96_RS00595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPY96_RS00675	COG3012	SEC-C Motif Domain Protein
LPY96_RS00675	COG3318	Belongs to the UPF0149 family
LPY96_RS00700	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPY96_RS00710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPY96_RS00715	COG0187	DNA topoisomerase II activity
LPY96_RS00725	COG0501	Belongs to the peptidase M48B family
LPY96_RS00755	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LPY96_RS00895	COG0793	Belongs to the peptidase S41A family
LPY96_RS00900	COG4942	peptidase
LPY96_RS00910	COG2234	aminopeptidase activity
LPY96_RS00930	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPY96_RS00940	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPY96_RS00945	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPY96_RS00950	COG1064	alcohol dehydrogenase
LPY96_RS00965	COG0493	'glutamate synthase
LPY96_RS00970	COG0067	glutamate synthase
LPY96_RS00970	COG0070	glutamate synthase
LPY96_RS00970	COG0069	glutamate synthase activity
LPY96_RS01020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LPY96_RS01035	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LPY96_RS01040	COG0297	glycogen (starch) synthase activity
LPY96_RS01040	COG0438	transferase activity, transferring glycosyl groups
LPY96_RS01060	COG0367	asparagine synthase
LPY96_RS01090	COG1132	(ABC) transporter
LPY96_RS01125	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LPY96_RS01210	COG1111	helicase
LPY96_RS01210	COG1205	dead DEAH box helicase
LPY96_RS01215	COG1272	protein, Hemolysin III
LPY96_RS01235	COG0300	oxidoreductase activity
LPY96_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS01295	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LPY96_RS01300	COG3710	Transcriptional regulator
LPY96_RS01320	COG2197	response regulator
LPY96_RS01325	COG4585	Histidine kinase
LPY96_RS01335	COG1304	FMN binding
LPY96_RS01385	COG0662	Cupin 2, conserved barrel domain protein
LPY96_RS01395	COG4772	TonB-dependent receptor
LPY96_RS01405	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LPY96_RS01435	COG0714	Associated with various cellular activities
LPY96_RS01480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPY96_RS01535	COG0366	Alpha amylase catalytic
LPY96_RS01540	COG0366	Alpha amylase catalytic
LPY96_RS01545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LPY96_RS01635	COG3504	Conjugal transfer protein
LPY96_RS01640	COG2948	multi-organism process
LPY96_RS01710	COG3041	Addiction module toxin RelE StbE family
LPY96_RS01715	COG3077	Addiction module antitoxin, RelB DinJ family
LPY96_RS01735	COG1192	Involved in chromosome partitioning
LPY96_RS01760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPY96_RS01765	COG3265	gluconokinase activity
LPY96_RS01770	COG2211	Major facilitator Superfamily
LPY96_RS01775	COG3459	Glycosyltransferase 36 associated
LPY96_RS01790	COG1971	Probably functions as a manganese efflux pump
LPY96_RS01795	COG1414	Transcriptional regulator
LPY96_RS01800	COG0738	Major facilitator superfamily
LPY96_RS01805	COG3254	rhamnose metabolic process
LPY96_RS01810	COG4948	Mandelate Racemase Muconate Lactonizing
LPY96_RS01815	COG0179	Fumarylacetoacetate (FAA) hydrolase
LPY96_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS01865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPY96_RS01875	COG3162	membrane
LPY96_RS01880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPY96_RS01890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPY96_RS01900	COG1846	Transcriptional regulator
LPY96_RS01900	COG1940	carbohydrate kinase activity
LPY96_RS01905	COG0708	Exodeoxyribonuclease III
LPY96_RS01920	COG2091	lysine biosynthetic process via aminoadipic acid
LPY96_RS01930	COG3540	Alkaline phosphatase
LPY96_RS01935	COG0357	Ribosomal RNA small subunit methyltransferase G
LPY96_RS01955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY96_RS01980	COG2159	amidohydrolase
LPY96_RS01990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LPY96_RS01995	COG0583	DNA-binding transcription factor activity
LPY96_RS02000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPY96_RS02010	COG0210	DNA helicase
LPY96_RS02195	COG0631	protein serine/threonine phosphatase activity
LPY96_RS02200	COG2815	serine threonine protein kinase
LPY96_RS02200	COG0515	serine threonine protein kinase
LPY96_RS02235	COG0408	coproporphyrinogen oxidase activity
LPY96_RS02250	COG0823	Involved in the tonB-independent uptake of proteins
LPY96_RS02250	COG1506	peptidase
LPY96_RS02250	COG4946	Tricorn protease homolog
LPY96_RS02270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPY96_RS02325	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS02340	COG0463	Glycosyl transferase, family 2
LPY96_RS02350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPY96_RS02355	COG3100	YcgL domain-containing protein
LPY96_RS02370	COG3387	PFAM Glycoside hydrolase 15-related
LPY96_RS02375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPY96_RS02390	COG2239	Acts as a magnesium transporter
LPY96_RS02405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPY96_RS02410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPY96_RS02445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LPY96_RS02455	COG0842	Transport permease protein
LPY96_RS02460	COG1131	(ABC) transporter
LPY96_RS02465	COG0633	Ferredoxin
LPY96_RS02465	COG0543	2 iron, 2 sulfur cluster binding
LPY96_RS02510	COG1476	TRANSCRIPTIONal
LPY96_RS02520	COG4555	ABC transporter
LPY96_RS02555	COG0625	glutathione transferase activity
LPY96_RS02630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPY96_RS02645	COG1199	ATP-dependent helicase activity
LPY96_RS02665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPY96_RS02705	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LPY96_RS02705	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LPY96_RS02710	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LPY96_RS02740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LPY96_RS02780	COG3237	CsbD-like
LPY96_RS02785	COG0180	Tryptophanyl-tRNA synthetase
LPY96_RS02790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPY96_RS02805	COG0697	spore germination
LPY96_RS02830	COG1136	(ABC) transporter
LPY96_RS02835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY96_RS02840	COG4585	Histidine kinase
LPY96_RS02845	COG2197	response regulator
LPY96_RS02860	COG0753	catalase activity
LPY96_RS02875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPY96_RS02880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPY96_RS02905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPY96_RS02930	COG0642	Histidine kinase
LPY96_RS02940	COG1090	epimerase
LPY96_RS02980	COG1690	Belongs to the RtcB family
LPY96_RS03005	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LPY96_RS03020	COG0606	chelatase, subunit chli
LPY96_RS03055	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LPY96_RS03060	COG1166	arginine decarboxylase activity
LPY96_RS03080	COG4221	oxidoreductase activity
LPY96_RS03095	COG0018	arginyl-trna synthetase
LPY96_RS03100	COG2003	Belongs to the UPF0758 family
LPY96_RS03105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPY96_RS03110	COG0756	dUTP diphosphatase activity
LPY96_RS03130	COG0463	Glycosyl transferase, family 2
LPY96_RS03145	COG1475	DNA binding
LPY96_RS03150	COG1192	Involved in chromosome partitioning
LPY96_RS03160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LPY96_RS03165	COG0708	Exodeoxyribonuclease III
LPY96_RS03170	COG2211	Major facilitator Superfamily
LPY96_RS03180	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LPY96_RS03185	COG0739	heme binding
LPY96_RS03190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPY96_RS03230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LPY96_RS03245	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LPY96_RS03275	COG0109	protoheme IX farnesyltransferase activity
LPY96_RS03290	COG0358	DNA primase activity
LPY96_RS03295	COG1295	ribonuclease BN
LPY96_RS03310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LPY96_RS03315	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LPY96_RS03325	COG2133	pyrroloquinoline quinone binding
LPY96_RS03330	COG4682	membrane
LPY96_RS03345	COG0531	amino acid
LPY96_RS03355	COG4948	Mandelate Racemase Muconate Lactonizing
LPY96_RS03365	COG3023	N-Acetylmuramoyl-L-alanine amidase
LPY96_RS03410	COG5383	Protein conserved in bacteria
LPY96_RS03420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPY96_RS03425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY96_RS03430	COG1473	amidohydrolase
LPY96_RS03435	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LPY96_RS03435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LPY96_RS03460	COG0583	DNA-binding transcription factor activity
LPY96_RS03465	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LPY96_RS03470	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LPY96_RS03475	COG3118	belongs to the thioredoxin family
LPY96_RS03485	COG2884	Cell division ATP-binding protein ftsE
LPY96_RS03490	COG2177	Part of the ABC transporter FtsEX involved in
LPY96_RS03495	COG2201	protein-glutamate methylesterase activity
LPY96_RS03500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LPY96_RS03505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPY96_RS03510	COG2860	membrane
LPY96_RS03515	COG1252	NADH dehydrogenase
LPY96_RS03530	COG0625	glutathione transferase activity
LPY96_RS03535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPY96_RS03555	COG0534	Mate efflux family protein
LPY96_RS03560	COG0616	signal peptide processing
LPY96_RS03570	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS03585	COG0009	L-threonylcarbamoyladenylate synthase
LPY96_RS03590	COG1754	DNA topoisomerase type I activity
LPY96_RS03590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPY96_RS03610	COG0758	DNA mediated transformation
LPY96_RS03615	COG1652	LysM domain
LPY96_RS03620	COG0242	peptide deformylase activity
LPY96_RS03625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPY96_RS03630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPY96_RS03630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LPY96_RS03680	COG1560	Kdo2-lipid A biosynthetic process
LPY96_RS03685	COG1490	D-aminoacyl-tRNA deacylase activity
LPY96_RS03690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPY96_RS03705	COG0582	viral genome integration into host DNA
LPY96_RS03740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LPY96_RS03765	COG0024	Methionine aminopeptidase
LPY96_RS03805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LPY96_RS03810	COG0583	DNA-binding transcription factor activity
LPY96_RS03900	COG1063	alcohol dehydrogenase
LPY96_RS03915	COG1132	(ABC) transporter
LPY96_RS03935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LPY96_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS03955	COG1294	oxidase, subunit
LPY96_RS03960	COG1271	oxidase subunit
LPY96_RS04005	COG3546	catalase activity
LPY96_RS04010	COG3685	Protein conserved in bacteria
LPY96_RS04030	COG2972	Histidine kinase
LPY96_RS04045	COG0531	amino acid
LPY96_RS04065	COG3590	peptidase
LPY96_RS04075	COG0667	Aldo Keto reductase
LPY96_RS04085	COG0583	DNA-binding transcription factor activity
LPY96_RS04095	COG3384	dioxygenase
LPY96_RS04105	COG1573	uracil-dna glycosylase
LPY96_RS04110	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LPY96_RS04115	COG0025	NhaP-type Na H and K H
LPY96_RS04120	COG1131	(ABC) transporter
LPY96_RS04125	COG0842	Transport permease protein
LPY96_RS04180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPY96_RS04205	COG2202	Pas domain
LPY96_RS04205	COG2205	protein histidine kinase activity
LPY96_RS04230	COG1187	pseudouridine synthase activity
LPY96_RS04235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPY96_RS04255	COG0784	Response regulator, receiver
LPY96_RS04255	COG2198	Histidine kinase
LPY96_RS04255	COG5002	protein histidine kinase activity
LPY96_RS04265	COG1666	GTP binding
LPY96_RS04270	COG0697	spore germination
LPY96_RS04275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPY96_RS04280	COG2011	ABC-type metal ion transport system permease component
LPY96_RS04330	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPY96_RS04340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPY96_RS04360	COG0356	it plays a direct role in the translocation of protons across the membrane
LPY96_RS04370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LPY96_RS04375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPY96_RS04380	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LPY96_RS04385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LPY96_RS04390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPY96_RS04395	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LPY96_RS04410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LPY96_RS04415	COG4191	Histidine kinase
LPY96_RS04430	COG0577	efflux transmembrane transporter activity
LPY96_RS04435	COG0577	efflux transmembrane transporter activity
LPY96_RS04440	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPY96_RS04440	COG1136	(ABC) transporter
LPY96_RS04445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY96_RS04450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPY96_RS04505	COG0339	signal peptide processing
LPY96_RS04520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPY96_RS04525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPY96_RS04540	COG2819	hydrolase of the alpha beta superfamily
LPY96_RS04550	COG1956	GAF domain-containing protein
LPY96_RS04555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LPY96_RS04565	COG0720	synthase
LPY96_RS04570	COG4206	TonB-dependent receptor
LPY96_RS04580	COG0513	Belongs to the DEAD box helicase family
LPY96_RS04590	COG0625	glutathione transferase activity
LPY96_RS04625	COG0626	cystathionine gamma-synthase activity
LPY96_RS04630	COG0438	transferase activity, transferring glycosyl groups
LPY96_RS04650	COG0438	transferase activity, transferring glycosyl groups
LPY96_RS04655	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LPY96_RS04670	COG2813	Specifically methylates the guanine in position
LPY96_RS04690	COG0463	Glycosyl transferase, family 2
LPY96_RS04705	COG2086	electron transfer activity
LPY96_RS04735	COG0662	Cupin 2, conserved barrel domain protein
LPY96_RS04735	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LPY96_RS04740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPY96_RS04770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPY96_RS04770	COG3218	ABC-type transport auxiliary lipoprotein component
LPY96_RS04775	COG1127	ABC transporter
LPY96_RS04780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPY96_RS04795	COG0442	prolyl-tRNA aminoacylation
LPY96_RS04805	COG1183	phosphatidylcholine synthase activity
LPY96_RS04840	COG0525	valine-tRNA ligase activity
LPY96_RS04855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPY96_RS04880	COG4974	Belongs to the 'phage' integrase family
LPY96_RS04885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPY96_RS04900	COG1404	Belongs to the peptidase S8 family
LPY96_RS04910	COG5295	Hep Hag repeat protein
LPY96_RS04915	COG1404	Belongs to the peptidase S8 family
LPY96_RS04920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPY96_RS04925	COG1459	type II secretion system
LPY96_RS04930	COG2165	general secretion pathway protein
LPY96_RS04935	COG4970	Tfp pilus assembly protein FimT
LPY96_RS04940	COG2165	general secretion pathway protein
LPY96_RS04945	COG4795	General secretion pathway protein
LPY96_RS04950	COG3156	type II secretion system protein K
LPY96_RS04955	COG3166	PFAM Fimbrial assembly family protein
LPY96_RS04970	COG1450	Type ii and iii secretion system protein
LPY96_RS04985	COG2188	Transcriptional regulator
LPY96_RS05030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LPY96_RS05045	COG1215	transferase activity, transferring glycosyl groups
LPY96_RS05050	COG1215	transferase activity, transferring glycosyl groups
LPY96_RS05055	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LPY96_RS05060	COG0457	Tetratricopeptide repeat
LPY96_RS05080	COG0242	peptide deformylase activity
LPY96_RS05085	COG1307	EDD domain protein, DegV family
LPY96_RS05105	COG0402	S-adenosylhomocysteine deaminase activity
LPY96_RS05110	COG3964	amidohydrolase
LPY96_RS05125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPY96_RS05130	COG0726	polysaccharide deacetylase
LPY96_RS05135	COG4773	Receptor
LPY96_RS05200	COG1162	GTPase activity
LPY96_RS05225	COG2211	Major facilitator Superfamily
LPY96_RS05230	COG1609	Transcriptional regulator
LPY96_RS05235	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS05240	COG2851	Citrate transporter
LPY96_RS05255	COG0642	Histidine kinase
LPY96_RS05265	COG2197	response regulator
LPY96_RS05280	COG0667	Aldo Keto reductase
LPY96_RS05285	COG0583	DNA-binding transcription factor activity
LPY96_RS05310	COG1301	dicarboxylic acid transport
LPY96_RS05315	COG0280	phosphate acetyltransferase
LPY96_RS05315	COG0281	malic enzyme
LPY96_RS05340	COG1560	Kdo2-lipid A biosynthetic process
LPY96_RS05345	COG1519	Transferase
LPY96_RS05350	COG1538	Outer membrane efflux protein
LPY96_RS05355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPY96_RS05375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LPY96_RS05380	COG0066	3-isopropylmalate dehydratase activity
LPY96_RS05385	COG0473	3-isopropylmalate dehydrogenase activity
LPY96_RS05390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LPY96_RS05410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LPY96_RS05415	COG0405	Gamma-glutamyltransferase
LPY96_RS05420	COG0840	transmembrane signaling receptor activity
LPY96_RS05430	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LPY96_RS05435	COG3710	Transcriptional regulator
LPY96_RS05455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LPY96_RS05465	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LPY96_RS05485	COG0563	adenylate kinase activity
LPY96_RS05490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPY96_RS05500	COG3781	membrane
LPY96_RS05505	COG0671	phosphoesterase, PA-phosphatase related
LPY96_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS05520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPY96_RS05525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPY96_RS05555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPY96_RS05570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LPY96_RS05580	COG0352	thiamine-phosphate diphosphorylase activity
LPY96_RS05585	COG1773	rubredoxin
LPY96_RS05590	COG2912	Transglutaminase-like superfamily
LPY96_RS05600	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LPY96_RS05610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPY96_RS05630	COG3079	Belongs to the UPF0149 family
LPY96_RS05635	COG0006	proline dipeptidase activity
LPY96_RS05645	COG0006	proline dipeptidase activity
LPY96_RS05660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPY96_RS05665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LPY96_RS05675	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LPY96_RS05680	COG1561	YicC-like family, N-terminal region
LPY96_RS05685	COG0194	GDP metabolic process
LPY96_RS05695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPY96_RS05705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPY96_RS05730	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LPY96_RS05765	COG0714	Associated with various cellular activities
LPY96_RS05785	COG2304	oxidoreductase activity
LPY96_RS05795	COG1301	dicarboxylic acid transport
LPY96_RS05800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LPY96_RS05810	COG0596	Alpha beta hydrolase
LPY96_RS05815	COG4773	Receptor
LPY96_RS05865	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LPY96_RS05870	COG4149	molybdate abc transporter
LPY96_RS05875	COG0725	ABC transporter, periplasmic molybdate-binding protein
LPY96_RS05880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPY96_RS05880	COG3453	Protein conserved in bacteria
LPY96_RS05890	COG3047	cAMP biosynthetic process
LPY96_RS05895	COG3047	cAMP biosynthetic process
LPY96_RS05905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPY96_RS05925	COG0126	phosphoglycerate kinase activity
LPY96_RS05940	COG0469	pyruvate kinase activity
LPY96_RS05945	COG3588	fructose-bisphosphate aldolase
LPY96_RS05950	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LPY96_RS05965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LPY96_RS05965	COG1648	precorrin-2 dehydrogenase activity
LPY96_RS05980	COG0784	Response regulator, receiver
LPY96_RS05980	COG2198	Histidine kinase
LPY96_RS05980	COG2205	protein histidine kinase activity
LPY96_RS06000	COG0175	sulfate reduction
LPY96_RS06005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LPY96_RS06010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LPY96_RS06015	COG0175	sulfate reduction
LPY96_RS06020	COG2895	sulfate adenylyltransferase (ATP) activity
LPY96_RS06020	COG0529	Catalyzes the synthesis of activated sulfate
LPY96_RS06030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPY96_RS06055	COG0308	aminopeptidase N
LPY96_RS06065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPY96_RS06080	COG4948	Mandelate Racemase Muconate Lactonizing
LPY96_RS06085	COG3250	beta-galactosidase activity
LPY96_RS06095	COG1609	Transcriptional regulator
LPY96_RS06105	COG1970	mechanosensitive ion channel activity
LPY96_RS06125	COG3273	potassium ion transport
LPY96_RS06125	COG0471	metal ion transport
LPY96_RS06130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPY96_RS06135	COG2022	thiamine diphosphate biosynthetic process
LPY96_RS06245	COG0189	ligase activity
LPY96_RS06255	COG0745	RESPONSE REGULATOR receiver
LPY96_RS06260	COG5002	protein histidine kinase activity
LPY96_RS06295	COG0237	dephospho-CoA kinase activity
LPY96_RS06300	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LPY96_RS06315	COG4969	Belongs to the N-Me-Phe pilin family
LPY96_RS06345	COG0045	succinate-CoA ligase (ADP-forming) activity
LPY96_RS06350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LPY96_RS06365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPY96_RS06365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPY96_RS06375	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPY96_RS06380	COG0564	pseudouridine synthase activity
LPY96_RS06400	COG0840	transmembrane signaling receptor activity
LPY96_RS06415	COG3387	PFAM Glycoside hydrolase 15-related
LPY96_RS06420	COG1877	trehalose-phosphatase activity
LPY96_RS06460	COG2827	Endonuclease containing a URI domain
LPY96_RS06465	COG4771	TonB-dependent receptor
LPY96_RS06475	COG0667	Aldo Keto reductase
LPY96_RS06480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LPY96_RS06485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LPY96_RS06490	COG1116	anion transmembrane transporter activity
LPY96_RS06495	COG0542	response to heat
LPY96_RS06500	COG4206	TonB-dependent receptor
LPY96_RS06520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPY96_RS06530	COG1492	cobalamin metabolic process
LPY96_RS06540	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LPY96_RS06565	COG0019	diaminopimelate decarboxylase activity
LPY96_RS06580	COG4264	IucA IucC family
LPY96_RS06590	COG4772	TonB-dependent receptor
LPY96_RS06615	COG4651	solute:proton antiporter activity
LPY96_RS06615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPY96_RS06685	COG0477	Major facilitator Superfamily
LPY96_RS06700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPY96_RS06715	COG0217	transcriptional regulatory protein
LPY96_RS06720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LPY96_RS06725	COG0632	four-way junction helicase activity
LPY96_RS06730	COG3158	transport of potassium into the cell
LPY96_RS06740	COG2255	four-way junction helicase activity
LPY96_RS06745	COG0824	Thioesterase
LPY96_RS06755	COG0848	biopolymer transport protein
LPY96_RS06765	COG0823	Involved in the tonB-independent uptake of proteins
LPY96_RS06770	COG2885	chlorophyll binding
LPY96_RS06780	COG0602	queuosine metabolic process
LPY96_RS06790	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LPY96_RS06795	COG3920	Histidine kinase
LPY96_RS06815	COG0840	transmembrane signaling receptor activity
LPY96_RS06845	COG0514	ATP-dependent DNA helicase (RecQ)
LPY96_RS06850	COG0783	Belongs to the Dps family
LPY96_RS06855	COG1643	Atp-dependent helicase
LPY96_RS06870	COG0837	glucose binding
LPY96_RS06885	COG0535	radical SAM domain protein
LPY96_RS06890	COG0535	radical SAM domain protein
LPY96_RS06895	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
LPY96_RS06900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LPY96_RS06910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPY96_RS06920	COG1215	transferase activity, transferring glycosyl groups
LPY96_RS06925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPY96_RS06935	COG1199	ATP-dependent helicase activity
LPY96_RS06945	COG1397	ADP-ribosylglycohydrolase
LPY96_RS06955	COG0189	ligase activity
LPY96_RS06970	COG0835	chemotaxis
LPY96_RS06975	COG0840	transmembrane signaling receptor activity
LPY96_RS07000	COG1446	asparaginase
LPY96_RS07005	COG3142	Participates in the control of copper homeostasis
LPY96_RS07040	COG3537	Alpha-1,2-mannosidase
LPY96_RS07085	COG1472	Belongs to the glycosyl hydrolase 3 family
LPY96_RS07095	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LPY96_RS07100	COG1388	LysM domain
LPY96_RS07100	COG3858	chitin binding
LPY96_RS07115	COG0837	glucose binding
LPY96_RS07120	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LPY96_RS07130	COG0494	nUDIX hydrolase
LPY96_RS07140	COG3956	TIGRFAM MazG family protein
LPY96_RS07145	COG1742	UPF0060 membrane protein
LPY96_RS07165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LPY96_RS07170	COG0509	glycine decarboxylation via glycine cleavage system
LPY96_RS07200	COG1960	acyl-CoA dehydrogenase activity
LPY96_RS07210	COG1309	transcriptional regulator
LPY96_RS07240	COG4771	TonB-dependent receptor
LPY96_RS07250	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LPY96_RS07255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPY96_RS07260	COG0463	Glycosyl transferase, family 2
LPY96_RS07265	COG0516	GMP reductase activity
LPY96_RS07265	COG0517	IMP dehydrogenase activity
LPY96_RS07270	COG2982	Protein involved in outer membrane biogenesis
LPY96_RS07275	COG1272	protein, Hemolysin III
LPY96_RS07280	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LPY96_RS07285	COG0739	heme binding
LPY96_RS07290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPY96_RS07295	COG0626	cystathionine gamma-synthase activity
LPY96_RS07300	COG0460	homoserine dehydrogenase
LPY96_RS07300	COG0527	aspartate kinase activity
LPY96_RS07310	COG1760	l-serine dehydratase
LPY96_RS07330	COG2353	YceI-like domain
LPY96_RS07335	COG2198	Histidine kinase
LPY96_RS07335	COG0784	Response regulator, receiver
LPY96_RS07335	COG2205	protein histidine kinase activity
LPY96_RS07340	COG2198	Histidine kinase
LPY96_RS07340	COG0784	Response regulator, receiver
LPY96_RS07340	COG5002	protein histidine kinase activity
LPY96_RS07360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LPY96_RS07370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LPY96_RS07375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LPY96_RS07380	COG0259	pyridoxamine-phosphate oxidase activity
LPY96_RS07390	COG1842	Phage shock protein A
LPY96_RS07415	COG0754	glutathionylspermidine amidase activity
LPY96_RS07500	COG0531	amino acid
LPY96_RS07510	COG2197	response regulator
LPY96_RS07540	COG1113	amino acid transport
LPY96_RS07550	COG1271	oxidase subunit
LPY96_RS07555	COG1294	oxidase, subunit
LPY96_RS07570	COG2239	Acts as a magnesium transporter
LPY96_RS07575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPY96_RS07580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPY96_RS07590	COG1660	Displays ATPase and GTPase activities
LPY96_RS07595	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LPY96_RS07600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPY96_RS07615	COG1137	ATPase activity
LPY96_RS07620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LPY96_RS07630	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LPY96_RS07640	COG0271	Belongs to the BolA IbaG family
LPY96_RS07645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPY96_RS07665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LPY96_RS07680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPY96_RS07690	COG0628	permease
LPY96_RS07700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LPY96_RS07705	COG3178	'Phosphotransferase
LPY96_RS07720	COG1555	photosystem II stabilization
LPY96_RS07740	COG1477	protein flavinylation
LPY96_RS07765	COG3128	pkhd-type hydroxylase
LPY96_RS07770	COG4774	siderophore transport
LPY96_RS07775	COG2146	nitrite reductase [NAD(P)H] activity
LPY96_RS07785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPY96_RS07790	COG0719	Fe-S assembly protein
LPY96_RS07795	COG0396	ATPase activity
LPY96_RS07800	COG0719	Fe-S assembly protein
LPY96_RS07805	COG1959	2 iron, 2 sulfur cluster binding
LPY96_RS07815	COG0693	protein deglycase activity
LPY96_RS07835	COG0739	heme binding
LPY96_RS07850	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LPY96_RS07875	COG0519	Catalyzes the synthesis of GMP from XMP
LPY96_RS07880	COG1678	Uncharacterized ACR, COG1678
LPY96_RS07885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LPY96_RS07890	COG0540	Belongs to the ATCase OTCase family
LPY96_RS07895	COG1764	response to oxidative stress
LPY96_RS07905	COG0384	phenazine biosynthesis protein PhzF
LPY96_RS07910	COG0384	phenazine biosynthesis protein PhzF
LPY96_RS07915	COG0527	aspartate kinase activity
LPY96_RS07930	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPY96_RS07945	COG0142	geranyltranstransferase activity
LPY96_RS07950	COG0629	single-stranded DNA binding
LPY96_RS07955	COG3706	GGDEF domain
LPY96_RS07955	COG2203	Gaf domain
LPY96_RS07955	COG4251	negative regulation of phosphorylation
LPY96_RS07955	COG5001	Diguanylate cyclase
LPY96_RS07960	COG3321	synthase
LPY96_RS07960	COG0604	alcohol dehydrogenase
LPY96_RS07960	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS07965	COG2080	2 iron, 2 sulfur cluster binding
LPY96_RS07970	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LPY96_RS07975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LPY96_RS07980	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LPY96_RS08015	COG2879	small protein
LPY96_RS08020	COG1966	Carbon starvation protein
LPY96_RS08025	COG1741	Belongs to the pirin family
LPY96_RS08040	COG1741	Belongs to the pirin family
LPY96_RS08050	COG1515	deoxyribonuclease V activity
LPY96_RS08055	COG0588	phosphoglycerate mutase activity
LPY96_RS08070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPY96_RS08075	COG2201	protein-glutamate methylesterase activity
LPY96_RS08080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LPY96_RS08085	COG2199	diguanylate cyclase activity
LPY96_RS08085	COG2202	Pas domain
LPY96_RS08085	COG2200	EAL domain
LPY96_RS08090	COG0835	chemotaxis
LPY96_RS08095	COG0840	transmembrane signaling receptor activity
LPY96_RS08100	COG0643	Histidine kinase
LPY96_RS08100	COG2198	Histidine kinase
LPY96_RS08130	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPY96_RS08140	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LPY96_RS08145	COG0745	RESPONSE REGULATOR receiver
LPY96_RS08150	COG2205	protein histidine kinase activity
LPY96_RS08165	COG4452	Inner membrane protein CreD
LPY96_RS08190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPY96_RS08195	COG0735	belongs to the Fur family
LPY96_RS08210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPY96_RS08220	COG1309	transcriptional regulator
LPY96_RS08225	COG0667	Aldo Keto reductase
LPY96_RS08240	COG2207	Transcriptional regulator
LPY96_RS08255	COG2814	Major facilitator Superfamily
LPY96_RS08380	COG5002	protein histidine kinase activity
LPY96_RS08380	COG5001	Diguanylate cyclase
LPY96_RS08385	COG1187	pseudouridine synthase activity
LPY96_RS08405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LPY96_RS08415	COG0475	glutathione-regulated potassium exporter activity
LPY96_RS08425	COG0745	RESPONSE REGULATOR receiver
LPY96_RS08430	COG1538	Outer membrane efflux protein
LPY96_RS08460	COG1132	(ABC) transporter
LPY96_RS08505	COG2155	Conserved Protein
LPY96_RS08535	COG3118	belongs to the thioredoxin family
LPY96_RS08545	COG0495	leucyl-tRNA aminoacylation
LPY96_RS08560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LPY96_RS08575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LPY96_RS08590	COG2968	Membrane
LPY96_RS08595	COG0424	maF-like protein
LPY96_RS08605	COG3164	Protein of unknown function
LPY96_RS08615	COG0312	modulator of DNA gyrase
LPY96_RS08620	COG3028	Belongs to the UPF0307 family
LPY96_RS08625	COG0312	modulator of DNA gyrase
LPY96_RS08635	COG4104	PAAR repeat-containing protein
LPY96_RS08640	COG0142	geranyltranstransferase activity
LPY96_RS08645	COG1722	exodeoxyribonuclease VII activity
LPY96_RS08650	COG0037	tRNA processing
LPY96_RS08655	COG1785	Belongs to the alkaline phosphatase family
LPY96_RS08660	COG1301	dicarboxylic acid transport
LPY96_RS08665	COG4106	trans-aconitate 2-methyltransferase activity
LPY96_RS08675	COG0791	NLP P60 protein
LPY96_RS08680	COG0791	NLP P60 protein
LPY96_RS08685	COG1047	Peptidyl-prolyl cis-trans
LPY96_RS08690	COG2311	Membrane
LPY96_RS08695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPY96_RS08700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPY96_RS08720	COG3590	peptidase
LPY96_RS08725	COG3590	peptidase
LPY96_RS08745	COG0489	protein tyrosine kinase activity
LPY96_RS08750	COG0717	Belongs to the dCTP deaminase family
LPY96_RS08790	COG1404	Belongs to the peptidase S8 family
LPY96_RS08795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPY96_RS08805	COG2336	PFAM SpoVT AbrB
LPY96_RS08815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPY96_RS08820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPY96_RS08835	COG0494	nUDIX hydrolase
LPY96_RS08840	COG0433	COG0433 Predicted ATPase
LPY96_RS08855	COG0688	phosphatidylethanolamine metabolic process
LPY96_RS08865	COG2890	protein-(glutamine-N5) methyltransferase activity
LPY96_RS08870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LPY96_RS08875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPY96_RS08880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPY96_RS08900	COG0101	tRNA pseudouridine synthase activity
LPY96_RS08905	COG0135	phosphoribosylanthranilate isomerase activity
LPY96_RS08915	COG0133	tryptophan synthase activity
LPY96_RS08925	COG0159	tryptophan synthase activity
LPY96_RS08930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LPY96_RS08935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPY96_RS08965	COG0300	oxidoreductase activity
LPY96_RS08970	COG0149	triose-phosphate isomerase activity
LPY96_RS08985	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPY96_RS08990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPY96_RS08995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPY96_RS09000	COG0649	NAD binding
LPY96_RS09005	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LPY96_RS09010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LPY96_RS09020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LPY96_RS09025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPY96_RS09050	COG1007	ATP synthesis coupled electron transport
LPY96_RS09060	COG0779	Required for maturation of 30S ribosomal subunits
LPY96_RS09065	COG0195	Participates in both transcription termination and antitermination
LPY96_RS09070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPY96_RS09075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPY96_RS09080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPY96_RS09085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LPY96_RS09090	COG1185	polyribonucleotide nucleotidyltransferase activity
LPY96_RS09125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPY96_RS09135	COG2095	MarC family integral membrane protein
LPY96_RS09145	COG1611	Belongs to the LOG family
LPY96_RS09205	COG3505	Type IV secretory pathway VirD4
LPY96_RS09225	COG2948	multi-organism process
LPY96_RS09245	COG3702	type iv secretory pathway
LPY96_RS09315	COG1082	Xylose isomerase domain protein TIM barrel
LPY96_RS09340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LPY96_RS09345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LPY96_RS09360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LPY96_RS09365	COG0072	phenylalanine-tRNA ligase activity
LPY96_RS09365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPY96_RS09415	COG0438	transferase activity, transferring glycosyl groups
LPY96_RS09420	COG0438	transferase activity, transferring glycosyl groups
LPY96_RS09430	COG0438	transferase activity, transferring glycosyl groups
LPY96_RS09455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPY96_RS09460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPY96_RS09465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPY96_RS09485	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LPY96_RS09495	COG1960	acyl-CoA dehydrogenase activity
LPY96_RS09510	COG3040	lipid binding
LPY96_RS09525	COG0322	excinuclease ABC activity
LPY96_RS09540	COG4191	Histidine kinase
LPY96_RS09540	COG0784	Response regulator, receiver
LPY96_RS09545	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LPY96_RS09550	COG1194	a g-specific adenine glycosylase
LPY96_RS09555	COG0552	protein localization to endoplasmic reticulum
LPY96_RS09565	COG3938	Belongs to the proline racemase family
LPY96_RS09570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPY96_RS09585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LPY96_RS09595	COG0006	proline dipeptidase activity
LPY96_RS09610	COG0531	amino acid
LPY96_RS09665	COG4206	TonB-dependent receptor
LPY96_RS09705	COG0326	Molecular chaperone. Has ATPase activity
LPY96_RS09710	COG0742	ribosomal rna small subunit methyltransferase
LPY96_RS09715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LPY96_RS09725	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LPY96_RS09730	COG0405	Gamma-glutamyltransferase
LPY96_RS09735	COG3291	Pkd domain containing protein
LPY96_RS09740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LPY96_RS09785	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LPY96_RS09790	COG0343	queuine tRNA-ribosyltransferase activity
LPY96_RS09795	COG1862	Preprotein translocase
LPY96_RS09805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPY96_RS09850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LPY96_RS09850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LPY96_RS09855	COG1105	Belongs to the carbohydrate kinase PfkB family
LPY96_RS09860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPY96_RS09860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPY96_RS09865	COG1609	Transcriptional regulator
LPY96_RS09870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPY96_RS09875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY96_RS09885	COG2902	Dehydrogenase
LPY96_RS09895	COG0477	Major facilitator Superfamily
LPY96_RS09905	COG0784	Response regulator, receiver
LPY96_RS09905	COG2205	protein histidine kinase activity
LPY96_RS09905	COG5002	protein histidine kinase activity
LPY96_RS09910	COG2733	membrane
LPY96_RS09920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LPY96_RS09925	COG2223	nitrite transmembrane transporter activity
LPY96_RS09930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LPY96_RS09935	COG0243	molybdopterin cofactor binding
LPY96_RS09945	COG0477	Major facilitator Superfamily
LPY96_RS09950	COG2703	oxygen carrier activity
LPY96_RS09960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPY96_RS09965	COG0174	glutamine synthetase
LPY96_RS09970	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LPY96_RS09985	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LPY96_RS10010	COG1176	ABC-type spermidine putrescine transport system, permease component I
LPY96_RS10015	COG1177	transmembrane transport
LPY96_RS10020	COG1012	belongs to the aldehyde dehydrogenase family
LPY96_RS10035	COG4535	Mg2 and Co2 transporter CorC
LPY96_RS10045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LPY96_RS10055	COG1702	phosphate starvation-inducible protein PhoH
LPY96_RS10060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPY96_RS10075	COG0741	lytic transglycosylase activity
LPY96_RS10080	COG0723	plastoquinol--plastocyanin reductase activity
LPY96_RS10085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LPY96_RS10090	COG2857	Cytochrome c1
LPY96_RS10095	COG0625	glutathione transferase activity
LPY96_RS10100	COG2969	positive regulation of protein catabolic process
LPY96_RS10120	COG1201	RNA secondary structure unwinding
LPY96_RS10125	COG2094	Belongs to the DNA glycosylase MPG family
LPY96_RS10130	COG0840	transmembrane signaling receptor activity
LPY96_RS10135	COG0835	chemotaxis
LPY96_RS10265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LPY96_RS10275	COG1570	exodeoxyribonuclease VII activity
LPY96_RS10280	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPY96_RS10285	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LPY96_RS10285	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPY96_RS10290	COG0802	atpase or kinase
LPY96_RS10295	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPY96_RS10300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LPY96_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS10330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPY96_RS10335	COG0501	Belongs to the peptidase M48B family
LPY96_RS10345	COG2081	HI0933 family
LPY96_RS10350	COG4681	YaeQ
LPY96_RS10360	COG0625	glutathione transferase activity
LPY96_RS10370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LPY96_RS10375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LPY96_RS10380	COG0513	Belongs to the DEAD box helicase family
LPY96_RS10385	COG0488	(ABC) transporter
LPY96_RS10400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPY96_RS10405	COG0483	inositol monophosphate 1-phosphatase activity
LPY96_RS10420	COG3300	MHYT domain
LPY96_RS10420	COG5001	Diguanylate cyclase
LPY96_RS10425	COG1509	lysine 2,3-aminomutase activity
LPY96_RS10430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPY96_RS10440	COG0402	S-adenosylhomocysteine deaminase activity
LPY96_RS10445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPY96_RS10505	COG4302	ethanolamine ammonia-lyase activity
LPY96_RS10530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPY96_RS10535	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LPY96_RS10555	COG2166	iron-sulfur cluster assembly
LPY96_RS10560	COG0215	cysteine-tRNA ligase activity
LPY96_RS10570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LPY96_RS10575	COG0137	argininosuccinate synthase activity
LPY96_RS10585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPY96_RS10590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LPY96_RS10600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LPY96_RS10605	COG0165	Argininosuccinate lyase
LPY96_RS10615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LPY96_RS10620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LPY96_RS10645	COG1294	oxidase, subunit
LPY96_RS10655	COG4988	ABC transporter
LPY96_RS10660	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LPY96_RS10665	COG1278	Cold shock
LPY96_RS10670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPY96_RS10690	COG1138	Cytochrome C-type biogenesis protein
LPY96_RS10695	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LPY96_RS10715	COG4133	protoheme IX ABC transporter activity
LPY96_RS10720	COG0436	Aminotransferase
LPY96_RS10740	COG1187	pseudouridine synthase activity
LPY96_RS10750	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LPY96_RS10755	COG2350	Protein conserved in bacteria
LPY96_RS10785	COG1175	transmembrane transport
LPY96_RS10790	COG0395	ABC-type sugar transport system, permease component
LPY96_RS10815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPY96_RS10820	COG2957	Belongs to the agmatine deiminase family
LPY96_RS10840	COG0539	negative regulation of cytoplasmic translation
LPY96_RS10845	COG0776	regulation of translation
LPY96_RS10855	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LPY96_RS10860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPY96_RS10870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPY96_RS10875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPY96_RS10875	COG0475	glutathione-regulated potassium exporter activity
LPY96_RS10895	COG0519	Catalyzes the synthesis of GMP from XMP
LPY96_RS10895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPY96_RS10900	COG0582	viral genome integration into host DNA
LPY96_RS10945	COG0667	Aldo Keto reductase
LPY96_RS10990	COG3451	type IV secretory pathway VirB4
LPY96_RS11005	COG3846	protein secretion by the type IV secretion system
LPY96_RS11030	COG3002	Belongs to the UPF0753 family
LPY96_RS11035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LPY96_RS11040	COG0583	DNA-binding transcription factor activity
LPY96_RS11060	COG2197	response regulator
LPY96_RS11080	COG1335	isochorismatase
LPY96_RS11090	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LPY96_RS11105	COG1914	H( )-stimulated, divalent metal cation uptake system
LPY96_RS11125	COG2814	Major facilitator Superfamily
LPY96_RS11135	COG0668	transmembrane transport
LPY96_RS11145	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LPY96_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS11165	COG1183	phosphatidylcholine synthase activity
LPY96_RS11175	COG3243	poly(R)-hydroxyalkanoic acid synthase
LPY96_RS11190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPY96_RS11190	COG0723	plastoquinol--plastocyanin reductase activity
LPY96_RS11200	COG2183	response to ionizing radiation
LPY96_RS11205	COG0784	Response regulator, receiver
LPY96_RS11205	COG2205	protein histidine kinase activity
LPY96_RS11280	COG0800	Aldolase
LPY96_RS11285	COG0129	dihydroxy-acid dehydratase activity
LPY96_RS11290	COG0363	glucosamine-6-phosphate deaminase activity
LPY96_RS11295	COG0837	glucose binding
LPY96_RS11300	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPY96_RS11325	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LPY96_RS11340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LPY96_RS11345	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LPY96_RS11355	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPY96_RS11360	COG1136	(ABC) transporter
LPY96_RS11375	COG0811	peptide transport
LPY96_RS11385	COG1132	(ABC) transporter
LPY96_RS11390	COG1663	tetraacyldisaccharide 4'-kinase activity
LPY96_RS11395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LPY96_RS11400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LPY96_RS11410	COG0322	excinuclease ABC activity
LPY96_RS11415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LPY96_RS11435	COG0582	viral genome integration into host DNA
LPY96_RS11450	COG0583	DNA-binding transcription factor activity
LPY96_RS11470	COG1074	ATP-dependent DNA helicase activity
LPY96_RS11490	COG3593	DNA synthesis involved in DNA repair
LPY96_RS11625	COG2814	Major facilitator Superfamily
LPY96_RS11635	COG2816	NAD+ diphosphatase activity
LPY96_RS11655	COG1960	acyl-CoA dehydrogenase activity
LPY96_RS11670	COG0477	Major facilitator Superfamily
LPY96_RS11675	COG0583	DNA-binding transcription factor activity
LPY96_RS11875	COG0270	DNA (cytosine-5-)-methyltransferase activity
LPY96_RS11890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPY96_RS11960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LPY96_RS12040	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPY96_RS12045	COG2081	HI0933 family
LPY96_RS12060	COG1054	Belongs to the UPF0176 family
LPY96_RS12070	COG1530	ribonuclease E activity
LPY96_RS12080	COG3064	Membrane
LPY96_RS12085	COG0428	transporter
LPY96_RS12095	COG2154	pterin-4-alpha-carbinolamine dehydratase
LPY96_RS12100	COG0316	Belongs to the HesB IscA family
LPY96_RS12100	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LPY96_RS12205	COG1238	metal cluster binding
LPY96_RS12240	COG3279	Response regulator of the LytR AlgR family
LPY96_RS12260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY96_RS12280	COG4566	intracellular signal transduction
LPY96_RS12305	COG2203	Gaf domain
LPY96_RS12305	COG3706	GGDEF domain
LPY96_RS12305	COG4251	negative regulation of phosphorylation
LPY96_RS12305	COG5001	Diguanylate cyclase
LPY96_RS12325	COG3685	Protein conserved in bacteria
LPY96_RS12355	COG1648	precorrin-2 dehydrogenase activity
LPY96_RS12355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LPY96_RS12365	COG0746	molybdenum cofactor guanylyltransferase activity
LPY96_RS12370	COG0303	'Molybdopterin
LPY96_RS12380	COG0708	Exodeoxyribonuclease III
LPY96_RS12410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LPY96_RS12490	COG4644	lycopene metabolic process
LPY96_RS12525	COG4456	Virulence-associated protein
LPY96_RS12535	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPY96_RS12680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LPY96_RS12685	COG0303	'Molybdopterin
LPY96_RS12695	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPY96_RS12705	COG1426	Protein conserved in bacteria
LPY96_RS12715	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LPY96_RS12730	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPY96_RS12730	COG1024	Enoyl-CoA hydratase
LPY96_RS12735	COG0183	Belongs to the thiolase family
LPY96_RS12740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LPY96_RS12745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPY96_RS12755	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LPY96_RS12765	COG1674	ftsk spoiiie
LPY96_RS12770	COG0492	ferredoxin-NADP+ reductase activity
LPY96_RS12780	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPY96_RS12805	COG0482	sulfurtransferase activity
LPY96_RS12810	COG2915	High frequency lysogenization protein hflD homolog
LPY96_RS12840	COG5002	protein histidine kinase activity
LPY96_RS12860	COG0784	Response regulator, receiver
LPY96_RS12860	COG0835	chemotaxis
LPY96_RS12870	COG1558	bacterial-type flagellum-dependent cell motility
LPY96_RS12875	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LPY96_RS12885	COG4787	bacterial-type flagellum-dependent cell motility
LPY96_RS12900	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LPY96_RS12905	COG1706	bacterial-type flagellum-dependent cell motility
LPY96_RS12910	COG1705	Flagellar rod assembly protein muramidase FlgJ
LPY96_RS12910	COG3951	Flagellar rod assembly protein muramidase FlgJ
LPY96_RS12920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LPY96_RS12925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LPY96_RS12935	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LPY96_RS12955	COG2197	response regulator
LPY96_RS12965	COG2201	protein-glutamate methylesterase activity
LPY96_RS12985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPY96_RS12990	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS12995	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS13040	COG1677	Flagellar hook-basal body complex protein FliE
LPY96_RS13090	COG3190	flagellar
LPY96_RS13105	COG1684	flagellar biosynthetic protein fliR
LPY96_RS13130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LPY96_RS13160	COG0643	Histidine kinase
LPY96_RS13160	COG0784	Response regulator, receiver
LPY96_RS13160	COG2198	Histidine kinase
LPY96_RS13235	COG1192	Involved in chromosome partitioning
LPY96_RS13250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LPY96_RS13255	COG1360	Flagellar Motor Protein
LPY96_RS13265	COG0835	chemotaxis
LPY96_RS13275	COG0745	RESPONSE REGULATOR receiver
LPY96_RS13285	COG0840	transmembrane signaling receptor activity
LPY96_RS13305	COG0840	transmembrane signaling receptor activity
LPY96_RS13315	COG0840	transmembrane signaling receptor activity
LPY96_RS13320	COG0840	transmembrane signaling receptor activity
LPY96_RS13325	COG0840	transmembrane signaling receptor activity
LPY96_RS13340	COG0840	transmembrane signaling receptor activity
LPY96_RS13350	COG0840	transmembrane signaling receptor activity
LPY96_RS13355	COG0840	transmembrane signaling receptor activity
LPY96_RS13365	COG0835	chemotaxis
LPY96_RS13375	COG0840	transmembrane signaling receptor activity
LPY96_RS13385	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LPY96_RS13390	COG2201	protein-glutamate methylesterase activity
LPY96_RS13400	COG2267	carboxylic ester hydrolase activity
LPY96_RS13430	COG0318	PFAM AMP-dependent synthetase and ligase
LPY96_RS13435	COG1024	Enoyl-CoA hydratase
LPY96_RS13440	COG0784	Response regulator, receiver
LPY96_RS13440	COG2198	Histidine kinase
LPY96_RS13440	COG2205	protein histidine kinase activity
LPY96_RS13450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPY96_RS13460	COG3279	Response regulator of the LytR AlgR family
LPY96_RS13495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPY96_RS13505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPY96_RS13520	COG0505	Belongs to the CarA family
LPY96_RS13525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPY96_RS13530	COG2258	MOSC domain
LPY96_RS13535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LPY96_RS13580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPY96_RS13600	COG0277	FAD linked oxidase domain protein
LPY96_RS13605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPY96_RS13615	COG0531	amino acid
LPY96_RS13620	COG0531	amino acid
LPY96_RS13625	COG0235	Class ii aldolase
LPY96_RS13630	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LPY96_RS13635	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LPY96_RS13650	COG0140	phosphoribosyl-ATP diphosphatase activity
LPY96_RS13650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LPY96_RS13655	COG0107	imidazoleglycerol-phosphate synthase activity
LPY96_RS13660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LPY96_RS13665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LPY96_RS13670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LPY96_RS13670	COG0131	Imidazoleglycerol-phosphate dehydratase
LPY96_RS13675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPY96_RS13680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LPY96_RS13685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPY96_RS13695	COG0124	histidyl-tRNA synthetase
LPY96_RS13700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPY96_RS13710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LPY96_RS13755	COG1649	PFAM Uncharacterised BCR, COG1649
LPY96_RS13755	COG0726	polysaccharide deacetylase
LPY96_RS13760	COG1215	transferase activity, transferring glycosyl groups
LPY96_RS13775	COG1012	belongs to the aldehyde dehydrogenase family
LPY96_RS13790	COG0167	dihydroorotate dehydrogenase activity
LPY96_RS13795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPY96_RS13805	COG1794	racemase activity, acting on amino acids and derivatives
LPY96_RS13820	COG0671	phosphoesterase, PA-phosphatase related
LPY96_RS13825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LPY96_RS13835	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LPY96_RS13840	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPY96_RS13845	COG5001	Diguanylate cyclase
LPY96_RS13845	COG4251	negative regulation of phosphorylation
LPY96_RS13845	COG3706	GGDEF domain
LPY96_RS13845	COG2203	Gaf domain
LPY96_RS13855	COG1472	Belongs to the glycosyl hydrolase 3 family
LPY96_RS13875	COG0166	Belongs to the GPI family
LPY96_RS13880	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LPY96_RS13885	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LPY96_RS13890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LPY96_RS13910	COG1469	GTP cyclohydrolase I activity
LPY96_RS13935	COG0477	Major facilitator Superfamily
LPY96_RS13940	COG2115	Belongs to the xylose isomerase family
LPY96_RS13945	COG1070	Carbohydrate kinase
LPY96_RS13955	COG1501	Belongs to the glycosyl hydrolase 31 family
LPY96_RS13990	COG0800	Aldolase
LPY96_RS13995	COG4948	Mandelate Racemase Muconate Lactonizing
LPY96_RS14005	COG3734	2-keto-3-deoxy-galactonokinase
LPY96_RS14010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LPY96_RS14020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LPY96_RS14035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPY96_RS14040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LPY96_RS14055	COG0351	phosphomethylpyrimidine kinase
LPY96_RS14080	COG0583	DNA-binding transcription factor activity
LPY96_RS14085	COG1741	Belongs to the pirin family
LPY96_RS14100	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LPY96_RS14105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPY96_RS14110	COG2137	regulation of response to DNA damage stimulus
LPY96_RS14115	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LPY96_RS14120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LPY96_RS14125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LPY96_RS14130	COG1546	Belongs to the CinA family
LPY96_RS14135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPY96_RS14145	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LPY96_RS14150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPY96_RS14160	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LPY96_RS14165	COG1534	Rna-binding protein
LPY96_RS14180	COG1238	metal cluster binding
LPY96_RS14185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPY96_RS14190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LPY96_RS14200	COG0585	pseudouridine synthase activity
LPY96_RS14205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LPY96_RS14210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LPY96_RS14215	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LPY96_RS14220	COG0148	phosphopyruvate hydratase activity
LPY96_RS14230	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPY96_RS14235	COG0504	CTP synthase activity
LPY96_RS14260	COG0306	phosphate transporter
LPY96_RS14270	COG1253	flavin adenine dinucleotide binding
LPY96_RS14285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LPY96_RS14290	COG0477	Major facilitator Superfamily
LPY96_RS14295	COG1132	(ABC) transporter
LPY96_RS14300	COG1136	(ABC) transporter
LPY96_RS14325	COG2264	protein methyltransferase activity
LPY96_RS14355	COG2244	polysaccharide biosynthetic process
LPY96_RS14425	COG2951	lytic endotransglycosylase activity
LPY96_RS14460	COG1595	DNA-templated transcription, initiation
LPY96_RS14475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LPY96_RS14485	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LPY96_RS14495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPY96_RS14545	COG0840	transmembrane signaling receptor activity
LPY96_RS14560	COG0583	DNA-binding transcription factor activity
LPY96_RS14565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LPY96_RS14570	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPY96_RS14585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LPY96_RS14590	COG0077	Prephenate dehydratase
LPY96_RS14590	COG1605	Chorismate mutase
LPY96_RS14595	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LPY96_RS14600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LPY96_RS14605	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LPY96_RS14645	COG1228	amidohydrolase
LPY96_RS14650	COG2986	histidine ammonia-lyase
LPY96_RS14660	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LPY96_RS14670	COG4993	Dehydrogenase
LPY96_RS14680	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LPY96_RS14690	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LPY96_RS14695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LPY96_RS14700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPY96_RS14715	COG3115	cell septum assembly
LPY96_RS14725	COG0359	binds to the 23S rRNA
LPY96_RS14730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPY96_RS14735	COG0360	Binds together with S18 to 16S ribosomal RNA
LPY96_RS14740	COG0316	Belongs to the HesB IscA family
LPY96_RS14745	COG0017	Asparaginyl-tRNA synthetase
LPY96_RS14765	COG2808	Putative FMN-binding domain
LPY96_RS14835	COG0288	reversible hydration of carbon dioxide
LPY96_RS14840	COG0662	Cupin 2, conserved barrel domain protein
LPY96_RS14855	COG3844	kynureninase activity
LPY96_RS14860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPY96_RS14865	COG2925	Exonuclease
LPY96_RS14890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LPY96_RS14895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPY96_RS14895	COG0116	Belongs to the methyltransferase superfamily
LPY96_RS14905	COG0488	(ABC) transporter
LPY96_RS14940	COG0494	nUDIX hydrolase
LPY96_RS14950	COG1024	Enoyl-CoA hydratase
LPY96_RS14960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPY96_RS14965	COG0659	secondary active sulfate transmembrane transporter activity
LPY96_RS14990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LPY96_RS14995	COG0573	inorganic phosphate transmembrane transporter activity
LPY96_RS15000	COG0581	inorganic phosphate transmembrane transporter activity
LPY96_RS15005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LPY96_RS15010	COG0704	Plays a role in the regulation of phosphate uptake
LPY96_RS15020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPY96_RS15040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPY96_RS15050	COG0557	exoribonuclease II activity
LPY96_RS15065	COG1960	acyl-CoA dehydrogenase activity
LPY96_RS15070	COG2226	methyltransferase
LPY96_RS15075	COG1410	methionine synthase
LPY96_RS15075	COG0646	methionine synthase
LPY96_RS15080	COG0646	methionine synthase
LPY96_RS15080	COG1410	methionine synthase
LPY96_RS15090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPY96_RS15115	COG2900	Belongs to the SlyX family
LPY96_RS15130	COG0386	Belongs to the glutathione peroxidase family
LPY96_RS15140	COG1725	Transcriptional regulator
LPY96_RS15145	COG1131	(ABC) transporter
LPY96_RS15175	COG1253	flavin adenine dinucleotide binding
LPY96_RS15195	COG2850	peptidyl-arginine hydroxylation
LPY96_RS15230	COG1132	(ABC) transporter
LPY96_RS15235	COG0583	DNA-binding transcription factor activity
LPY96_RS15270	COG0484	heat shock protein binding
LPY96_RS15275	COG0443	Heat shock 70 kDa protein
LPY96_RS15280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LPY96_RS15285	COG1420	regulation of RNA biosynthetic process
LPY96_RS15290	COG0497	DNA recombination
LPY96_RS15300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPY96_RS15315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LPY96_RS15395	COG3706	GGDEF domain
LPY96_RS15440	COG0583	DNA-binding transcription factor activity
LPY96_RS15450	COG0415	Belongs to the DNA photolyase family
LPY96_RS15455	COG0305	Participates in initiation and elongation during chromosome replication
LPY96_RS15465	COG0367	asparagine synthase
LPY96_RS15485	COG1960	acyl-CoA dehydrogenase activity
LPY96_RS15500	COG0084	hydrolase, TatD family'
LPY96_RS15505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LPY96_RS15565	COG0386	Belongs to the glutathione peroxidase family
LPY96_RS15570	COG0339	signal peptide processing
LPY96_RS15620	COG2814	Major facilitator Superfamily
LPY96_RS15625	COG1566	PFAM secretion protein HlyD family protein
LPY96_RS15650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPY96_RS15665	COG4774	siderophore transport
LPY96_RS15675	COG0367	asparagine synthase
LPY96_RS15680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPY96_RS15685	COG1393	Belongs to the ArsC family
LPY96_RS15735	COG0052	Belongs to the universal ribosomal protein uS2 family
LPY96_RS15740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPY96_RS15750	COG0528	UMP kinase activity
LPY96_RS15755	COG0233	cytoplasmic translational termination
LPY96_RS15760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LPY96_RS15765	COG0575	Belongs to the CDS family
LPY96_RS15770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LPY96_RS15775	COG0750	zinc metalloprotease
LPY96_RS15790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPY96_RS15795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPY96_RS15800	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPY96_RS15805	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPY96_RS15810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPY96_RS15820	COG0825	malonyl-CoA metabolic process
LPY96_RS15835	COG1981	membrane
LPY96_RS15855	COG1695	Transcriptional regulator
LPY96_RS15875	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LPY96_RS15885	COG2040	homocysteine
LPY96_RS15890	COG0833	amino acid
LPY96_RS15895	COG0346	lactoylglutathione lyase activity
LPY96_RS15900	COG1131	(ABC) transporter
LPY96_RS15915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPY96_RS15915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPY96_RS15925	COG2878	Part of a membrane complex involved in electron transport
LPY96_RS15940	COG1595	DNA-templated transcription, initiation
LPY96_RS15965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPY96_RS15980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPY96_RS15985	COG0251	oxidation-reduction process
LPY96_RS15995	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LPY96_RS15995	COG0392	lysyltransferase activity
LPY96_RS16030	COG2814	Major facilitator Superfamily
LPY96_RS16040	COG1902	pentaerythritol trinitrate reductase activity
LPY96_RS16045	COG2824	Alkylphosphonate utilization operon protein PhnA
LPY96_RS16055	COG1047	Peptidyl-prolyl cis-trans
LPY96_RS16060	COG1077	Cell shape determining protein MreB Mrl
LPY96_RS16075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LPY96_RS16085	COG5487	UPF0391 membrane protein
LPY96_RS16090	COG1451	nucleotide metabolic process
LPY96_RS16115	COG0183	Belongs to the thiolase family
LPY96_RS16145	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LPY96_RS16145	COG1793	dna ligase
LPY96_RS16155	COG1793	dna ligase
LPY96_RS16160	COG1201	RNA secondary structure unwinding
LPY96_RS16170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPY96_RS16175	COG1278	Cold shock
LPY96_RS16180	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LPY96_RS16185	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LPY96_RS16190	COG1472	Belongs to the glycosyl hydrolase 3 family
LPY96_RS16195	COG3046	protein related to deoxyribodipyrimidine photolyase
LPY96_RS16200	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
LPY96_RS16205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LPY96_RS16215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPY96_RS16225	COG1381	Involved in DNA repair and RecF pathway recombination
LPY96_RS16230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPY96_RS16235	COG0571	ribonuclease III activity
LPY96_RS16250	COG0481	GTPase activity
LPY96_RS16255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPY96_RS16270	COG1024	Enoyl-CoA hydratase
LPY96_RS16270	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPY96_RS16295	COG1960	acyl-CoA dehydrogenase activity
LPY96_RS16315	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LPY96_RS16320	COG3250	beta-galactosidase activity
LPY96_RS16380	COG3209	COG3209 Rhs family protein
LPY96_RS16390	COG3209	COG3209 Rhs family protein
LPY96_RS16400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPY96_RS16410	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LPY96_RS16430	COG0534	Mate efflux family protein
LPY96_RS16435	COG0335	large ribosomal subunit rRNA binding
LPY96_RS16440	COG0336	Belongs to the RNA methyltransferase TrmD family
LPY96_RS16445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPY96_RS16450	COG0228	four-way junction DNA binding
LPY96_RS16455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPY96_RS16465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPY96_RS16470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LPY96_RS16505	COG0784	Response regulator, receiver
LPY96_RS16505	COG4191	Histidine kinase
LPY96_RS16510	COG2205	protein histidine kinase activity
LPY96_RS16510	COG4999	Histidine kinase
LPY96_RS16510	COG3437	response regulator, receiver
LPY96_RS16510	COG3850	Histidine kinase
LPY96_RS16515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LPY96_RS16530	COG5507	3-demethylubiquinone-9 3-methyltransferase
LPY96_RS16540	COG4771	TonB-dependent receptor
LPY96_RS16565	COG2172	sigma factor antagonist activity
LPY96_RS16570	COG1366	Belongs to the anti-sigma-factor antagonist family
LPY96_RS16575	COG1366	Belongs to the anti-sigma-factor antagonist family
LPY96_RS16590	COG0326	Molecular chaperone. Has ATPase activity
LPY96_RS16595	COG2207	Transcriptional regulator
LPY96_RS16605	COG3152	Membrane
LPY96_RS16620	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LPY96_RS16625	COG1845	cytochrome c oxidase, subunit III
LPY96_RS16630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LPY96_RS16665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPY96_RS16665	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LPY96_RS16760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LPY96_RS16765	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LPY96_RS16770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPY96_RS16775	COG0196	riboflavin kinase activity
LPY96_RS16780	COG0728	peptidoglycan biosynthetic process
LPY96_RS16785	COG0268	Binds directly to 16S ribosomal RNA
LPY96_RS16790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPY96_RS16795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPY96_RS16800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LPY96_RS16805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPY96_RS16810	COG0824	Thioesterase
LPY96_RS16825	COG1946	Acyl-CoA thioesterase
LPY96_RS16845	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LPY96_RS16855	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LPY96_RS16885	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LPY96_RS16900	COG2197	response regulator
LPY96_RS16905	COG4585	Histidine kinase
LPY96_RS16915	COG0850	regulation of cytokinetic process
LPY96_RS16920	COG2894	cell division
LPY96_RS16925	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LPY96_RS16935	COG0642	Histidine kinase
LPY96_RS16940	COG0745	RESPONSE REGULATOR receiver
LPY96_RS16970	COG2814	Major facilitator Superfamily
LPY96_RS16975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPY96_RS16975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPY96_RS16985	COG0656	L-ascorbic acid biosynthetic process
LPY96_RS16990	COG0753	catalase activity
LPY96_RS17020	COG1917	Cupin 2, conserved barrel domain protein
LPY96_RS17020	COG2207	Transcriptional regulator
LPY96_RS17045	COG0823	Involved in the tonB-independent uptake of proteins
LPY96_RS17045	COG1506	peptidase
LPY96_RS17060	COG1297	OPT oligopeptide transporter protein
LPY96_RS17075	COG0587	DNA-directed DNA polymerase activity
LPY96_RS17090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LPY96_RS17125	COG2080	2 iron, 2 sulfur cluster binding
LPY96_RS17130	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LPY96_RS17135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LPY96_RS17160	COG0492	ferredoxin-NADP+ reductase activity
LPY96_RS17170	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS17175	COG3537	Alpha-1,2-mannosidase
LPY96_RS17180	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS17195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPY96_RS17205	COG1309	transcriptional regulator
LPY96_RS17220	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LPY96_RS17230	COG1196	nuclear chromosome segregation
LPY96_RS17235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LPY96_RS17265	COG1309	transcriptional regulator
LPY96_RS17270	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS17280	COG0308	aminopeptidase N
LPY96_RS17285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LPY96_RS17295	COG0330	HflC and HflK could
LPY96_RS17300	COG0330	HflC and HflK could
LPY96_RS17320	COG0678	peroxiredoxin activity
LPY96_RS17330	COG4953	penicillin-binding protein 1C
LPY96_RS17345	COG2373	Large extracellular alpha-helical protein
LPY96_RS17390	COG3829	transcription factor binding
LPY96_RS17415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPY96_RS17420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPY96_RS17435	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS17450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPY96_RS17455	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LPY96_RS17460	COG1399	metal-binding, possibly nucleic acid-binding protein
LPY96_RS17465	COG0424	maF-like protein
LPY96_RS17485	COG0714	Associated with various cellular activities
LPY96_RS17505	COG0537	adenosine 5'-monophosphoramidase activity
LPY96_RS17510	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LPY96_RS17515	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPY96_RS17520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPY96_RS17660	COG0314	molybdopterin synthase activity
LPY96_RS17665	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LPY96_RS17670	COG0315	cyclic pyranopterin monophosphate synthase activity
LPY96_RS17680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LPY96_RS17685	COG1234	tRNA 3'-trailer cleavage
LPY96_RS17690	COG3642	lipopolysaccharide core region biosynthetic process
LPY96_RS17695	COG0859	PFAM glycosyl transferase family 9
LPY96_RS17710	COG0631	protein serine/threonine phosphatase activity
LPY96_RS17715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPY96_RS17720	COG0328	RNA-DNA hybrid ribonuclease activity
LPY96_RS17730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPY96_RS17740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPY96_RS17770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPY96_RS17780	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPY96_RS17790	COG3852	Histidine kinase
LPY96_RS17825	COG0473	3-isopropylmalate dehydrogenase activity
LPY96_RS17840	COG4783	chaperone-mediated protein folding
LPY96_RS17855	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LPY96_RS17865	COG0438	transferase activity, transferring glycosyl groups
LPY96_RS17870	COG0671	phosphoesterase, PA-phosphatase related
LPY96_RS17875	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPY96_RS17885	COG3291	Pkd domain containing protein
LPY96_RS17920	COG0285	dihydrofolate synthase activity
LPY96_RS17930	COG0406	alpha-ribazole phosphatase activity
LPY96_RS17960	COG1063	alcohol dehydrogenase
LPY96_RS17970	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LPY96_RS17975	COG4208	sulfate ABC transporter
LPY96_RS17980	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LPY96_RS17985	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LPY96_RS17990	COG0156	8-amino-7-oxononanoate synthase activity
LPY96_RS18015	COG0604	alcohol dehydrogenase
LPY96_RS18020	COG1902	pentaerythritol trinitrate reductase activity
LPY96_RS18020	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPY96_RS18030	COG0625	glutathione transferase activity
LPY96_RS18035	COG0039	L-malate dehydrogenase activity
LPY96_RS18040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPY96_RS18045	COG1217	gtp-binding protein TYPA
LPY96_RS18065	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LPY96_RS18080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LPY96_RS18085	COG0203	ribosomal protein L17
LPY96_RS18110	COG0201	protein transport
LPY96_RS18115	COG0200	Binds to the 23S rRNA
LPY96_RS18120	COG1841	ribosomal large subunit assembly
LPY96_RS18130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LPY96_RS18135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LPY96_RS18140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LPY96_RS18150	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LPY96_RS18155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LPY96_RS18165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LPY96_RS18170	COG0255	Belongs to the universal ribosomal protein uL29 family
LPY96_RS18175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LPY96_RS18180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPY96_RS18190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPY96_RS18195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LPY96_RS18200	COG0089	rRNA binding
LPY96_RS18205	COG0088	Forms part of the polypeptide exit tunnel
LPY96_RS18210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LPY96_RS18215	COG0051	transcription antitermination factor activity, RNA binding
LPY96_RS18220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPY96_RS18225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LPY96_RS18230	COG0049	tRNA binding
LPY96_RS18235	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LPY96_RS18240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LPY96_RS18245	COG0085	RNA polymerase activity
LPY96_RS18250	COG0222	ribosome binding
LPY96_RS18255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LPY96_RS18260	COG0081	regulation of translation
LPY96_RS18265	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPY96_RS18270	COG0250	Participates in transcription elongation, termination and antitermination
LPY96_RS18285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPY96_RS18305	COG0012	GTP binding
LPY96_RS18310	COG0193	aminoacyl-tRNA hydrolase activity
LPY96_RS18315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LPY96_RS18320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPY96_RS18330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LPY96_RS18335	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LPY96_RS18345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LPY96_RS18350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LPY96_RS18360	COG0521	Mo-molybdopterin cofactor biosynthetic process
LPY96_RS18375	COG1254	Belongs to the acylphosphatase family
LPY96_RS18380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPY96_RS18385	COG1295	ribonuclease BN
LPY96_RS18410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LPY96_RS18415	COG1404	Belongs to the peptidase S8 family
LPY96_RS18420	COG1404	Belongs to the peptidase S8 family
LPY96_RS18430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPY96_RS18445	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LPY96_RS18470	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LPY96_RS18500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPY96_RS18500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPY96_RS18520	COG2890	protein-(glutamine-N5) methyltransferase activity
LPY96_RS18530	COG3634	alkyl hydroperoxide reductase activity
LPY96_RS18535	COG0583	DNA-binding transcription factor activity
LPY96_RS18540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPY96_RS18545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LPY96_RS18555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPY96_RS18565	COG2197	response regulator
LPY96_RS18590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPY96_RS18600	COG0697	spore germination
LPY96_RS18640	COG3386	PFAM SMP-30 Gluconolaconase
LPY96_RS18660	COG1024	Enoyl-CoA hydratase
LPY96_RS18670	COG0318	PFAM AMP-dependent synthetase and ligase
LPY96_RS18675	COG0583	DNA-binding transcription factor activity
LPY96_RS18680	COG3384	dioxygenase
LPY96_RS18710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPY96_RS18715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPY96_RS18730	COG2096	Adenosyltransferase
LPY96_RS18735	COG0123	including yeast histone deacetylase and acetoin utilization protein
LPY96_RS18750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LPY96_RS18755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPY96_RS18760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LPY96_RS18765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LPY96_RS18770	COG2967	ApaG domain
LPY96_RS18775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LPY96_RS18795	COG0747	negative chemotaxis
LPY96_RS18825	COG0431	NADPH-dependent FMN reductase
LPY96_RS18830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LPY96_RS18840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LPY96_RS18845	COG1116	anion transmembrane transporter activity
LPY96_RS18855	COG3829	transcription factor binding
LPY96_RS18870	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPY96_RS18875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LPY96_RS18895	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LPY96_RS18905	COG0642	Histidine kinase
LPY96_RS18920	COG4181	ATPase activity
LPY96_RS18930	COG2175	clavaminate synthase activity
LPY96_RS18940	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LPY96_RS18945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LPY96_RS18965	COG4771	TonB-dependent receptor
LPY96_RS18975	COG0667	Aldo Keto reductase
LPY96_RS18980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LPY96_RS18985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPY96_RS18995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPY96_RS19000	COG4106	trans-aconitate 2-methyltransferase activity
LPY96_RS19050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LPY96_RS19060	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LPY96_RS19090	COG0366	Alpha amylase catalytic
LPY96_RS19115	COG0604	alcohol dehydrogenase
LPY96_RS19115	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS19115	COG3321	synthase
LPY96_RS19125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LPY96_RS19170	COG2948	multi-organism process
LPY96_RS19200	COG2885	chlorophyll binding
LPY96_RS19230	COG1475	DNA binding
LPY96_RS19405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPY96_RS19410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPY96_RS19435	COG0494	nUDIX hydrolase
LPY96_RS19440	COG0653	protein targeting
LPY96_RS19445	COG0741	lytic transglycosylase activity
LPY96_RS19445	COG1196	nuclear chromosome segregation
LPY96_RS19445	COG0739	heme binding
LPY96_RS19455	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LPY96_RS19470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LPY96_RS19475	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPY96_RS19480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPY96_RS19485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LPY96_RS19495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPY96_RS19500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPY96_RS19505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LPY96_RS19515	COG3116	cell division
LPY96_RS19520	COG0275	rRNA processing
LPY96_RS19565	COG0792	nuclease activity
LPY96_RS19570	COG1988	membrane-bound metal-dependent
LPY96_RS19575	COG0277	FAD linked oxidase domain protein
LPY96_RS19585	COG0745	RESPONSE REGULATOR receiver
LPY96_RS19605	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LPY96_RS19610	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LPY96_RS19615	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LPY96_RS19635	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LPY96_RS19640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPY96_RS19645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LPY96_RS19670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPY96_RS19670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPY96_RS19680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LPY96_RS19685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPY96_RS19695	COG0488	(ABC) transporter
LPY96_RS19705	COG0697	spore germination
LPY96_RS19715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LPY96_RS19730	COG3791	Glutathione-dependent formaldehyde-activating
LPY96_RS19760	COG2205	protein histidine kinase activity
LPY96_RS19780	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LPY96_RS19795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPY96_RS19810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LPY96_RS19815	COG1012	belongs to the aldehyde dehydrogenase family
LPY96_RS19820	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LPY96_RS19825	COG0617	tRNA 3'-terminal CCA addition
LPY96_RS19835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LPY96_RS19840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPY96_RS19845	COG1609	Transcriptional regulator
LPY96_RS19855	COG2188	Transcriptional regulator
LPY96_RS19900	COG4795	General secretion pathway protein
LPY96_RS19920	COG1459	type II secretion system
LPY96_RS19975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LPY96_RS19980	COG4191	Histidine kinase
LPY96_RS19985	COG0784	Response regulator, receiver
LPY96_RS19990	COG4251	negative regulation of phosphorylation
LPY96_RS19995	COG2823	Periplasmic or secreted lipoprotein
LPY96_RS20000	COG0673	inositol 2-dehydrogenase activity
LPY96_RS20005	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LPY96_RS20040	COG1056	cytidyltransferase-related domain
LPY96_RS20040	COG1051	belongs to the nudix hydrolase family
LPY96_RS20050	COG0583	DNA-binding transcription factor activity
LPY96_RS20065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LPY96_RS20070	COG0321	lipoyl(octanoyl) transferase activity
LPY96_RS20075	COG2921	Belongs to the UPF0250 family
LPY96_RS20085	COG1686	Belongs to the peptidase S11 family
LPY96_RS20090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LPY96_RS20095	COG2951	lytic endotransglycosylase activity
LPY96_RS20105	COG0772	Belongs to the SEDS family
LPY96_RS20120	COG1792	Involved in formation and maintenance of cell shape
LPY96_RS20125	COG1077	Cell shape determining protein MreB Mrl
LPY96_RS20130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPY96_RS20135	COG3284	Transcriptional regulator
LPY96_RS20145	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LPY96_RS20155	COG2010	Cytochrome c
LPY96_RS20180	COG0308	aminopeptidase N
LPY96_RS20185	COG3300	MHYT domain
LPY96_RS20185	COG5001	Diguanylate cyclase
LPY96_RS20190	COG2226	methyltransferase
LPY96_RS20215	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LPY96_RS20220	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LPY96_RS20225	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LPY96_RS20235	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LPY96_RS20245	COG2832	Protein of unknown function (DUF454)
LPY96_RS20255	COG0436	Aminotransferase
LPY96_RS20265	COG1505	serine-type exopeptidase activity
LPY96_RS20290	COG0181	hydroxymethylbilane synthase activity
LPY96_RS20300	COG3275	phosphorelay sensor kinase activity
LPY96_RS20310	COG2943	transferase activity, transferring hexosyl groups
LPY96_RS20330	COG0659	secondary active sulfate transmembrane transporter activity
LPY96_RS20335	COG5297	Belongs to the glycosyl hydrolase family 6
LPY96_RS20335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPY96_RS20340	COG0840	transmembrane signaling receptor activity
LPY96_RS20345	COG5001	Diguanylate cyclase
LPY96_RS20380	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LPY96_RS20400	COG1113	amino acid transport
LPY96_RS20415	COG0697	spore germination
LPY96_RS20450	COG0823	Involved in the tonB-independent uptake of proteins
LPY96_RS20450	COG1506	peptidase
LPY96_RS20460	COG2409	Drug exporters of the RND superfamily
LPY96_RS20490	COG0435	Glutathione S-transferase
LPY96_RS20500	COG4221	oxidoreductase activity
LPY96_RS20515	COG4221	oxidoreductase activity
LPY96_RS20560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPY96_RS20600	COG0546	phosphoglycolate phosphatase activity
LPY96_RS20605	COG1802	Transcriptional regulator
LPY96_RS20615	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LPY96_RS20645	COG3052	prosthetic group binding
LPY96_RS20670	COG2353	YceI-like domain
LPY96_RS20675	COG0778	Nitroreductase
LPY96_RS20690	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LPY96_RS20695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LPY96_RS20705	COG3386	PFAM SMP-30 Gluconolaconase
LPY96_RS20720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LPY96_RS20740	COG0459	protein refolding
LPY96_RS20755	COG2356	endonuclease I
LPY96_RS20760	COG0300	oxidoreductase activity
LPY96_RS20785	COG1324	tolerance protein
LPY96_RS20795	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LPY96_RS20800	COG0511	ligase activity, forming carbon-carbon bonds
LPY96_RS20810	COG0439	Biotin carboxylase
LPY96_RS20835	COG2264	protein methyltransferase activity
LPY96_RS20860	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LPY96_RS20865	COG4589	Belongs to the CDS family
LPY96_RS20890	COG2453	phosphatase
LPY96_RS20890	COG0671	phosphoesterase, PA-phosphatase related
LPY96_RS20895	COG2267	carboxylic ester hydrolase activity
LPY96_RS20900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LPY96_RS20905	COG0138	bifunctional purine biosynthesis protein purh
LPY96_RS20915	COG0151	Belongs to the GarS family
LPY96_RS20925	COG1289	transmembrane transporter activity
LPY96_RS20930	COG2814	Major facilitator Superfamily
LPY96_RS20940	COG2814	Major facilitator Superfamily
LPY96_RS20955	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPY96_RS20970	COG0316	Belongs to the HesB IscA family
LPY96_RS21010	COG1051	belongs to the nudix hydrolase family
LPY96_RS21025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LPY96_RS21035	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LPY96_RS21045	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LPY96_RS21050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPY96_RS21060	COG0134	indole-3-glycerol-phosphate synthase activity
LPY96_RS21065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPY96_RS21090	COG1597	lipid kinase activity
LPY96_RS21095	COG0456	acetyltransferase
LPY96_RS21110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPY96_RS21115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LPY96_RS21135	COG3179	chitinase
LPY96_RS21155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LPY96_RS21155	COG2111	Na H antiporter
LPY96_RS21160	COG1006	Multisubunit Na H antiporter MnhC subunit
LPY96_RS21165	COG0651	ATP synthesis coupled electron transport
LPY96_RS21175	COG2212	antiporter activity
LPY96_RS21180	COG1320	monovalent cation:proton antiporter activity
LPY96_RS21200	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LPY96_RS21205	COG2852	Protein conserved in bacteria
LPY96_RS21225	COG3104	oligopeptide transport
LPY96_RS21230	COG3483	tryptophan 2,3-dioxygenase activity
LPY96_RS21240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LPY96_RS21255	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPY96_RS21265	COG0513	Belongs to the DEAD box helicase family
LPY96_RS21275	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS21280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPY96_RS21310	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS21315	COG0702	epimerase
LPY96_RS21345	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LPY96_RS21350	COG0297	glycogen (starch) synthase activity
LPY96_RS21360	COG2354	Protein conserved in bacteria
LPY96_RS21365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LPY96_RS21370	COG1368	sulfuric ester hydrolase activity
LPY96_RS21375	COG1511	domain protein
LPY96_RS21375	COG3264	Mechanosensitive ion channel
LPY96_RS21450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LPY96_RS21525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LPY96_RS21530	COG1040	competence protein
LPY96_RS21535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LPY96_RS21540	COG0156	8-amino-7-oxononanoate synthase activity
LPY96_RS21550	COG2267	carboxylic ester hydrolase activity
LPY96_RS21555	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS21580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LPY96_RS21590	COG0445	tRNA wobble uridine modification
LPY96_RS21610	COG1414	Transcriptional regulator
LPY96_RS21620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LPY96_RS21625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPY96_RS21635	COG3485	protocatechuate 3,4-dioxygenase
LPY96_RS21650	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LPY96_RS21655	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LPY96_RS21680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPY96_RS21685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LPY96_RS21745	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPY96_RS21760	COG0129	dihydroxy-acid dehydratase activity
LPY96_RS21810	COG1733	regulation of RNA biosynthetic process
LPY96_RS21815	COG0702	epimerase
LPY96_RS21845	COG0583	DNA-binding transcription factor activity
LPY96_RS21850	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPY96_RS21875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY96_RS21880	COG2205	protein histidine kinase activity
LPY96_RS21885	COG0745	RESPONSE REGULATOR receiver
LPY96_RS21905	COG1902	pentaerythritol trinitrate reductase activity
LPY96_RS21910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LPY96_RS21925	COG2814	Major facilitator Superfamily
LPY96_RS21965	COG0084	hydrolase, TatD family'
LPY96_RS21985	COG2252	PERMEase
LPY96_RS22030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LPY96_RS22050	COG2072	flavoprotein involved in K transport
LPY96_RS22055	COG2351	hydroxyisourate hydrolase activity
LPY96_RS22060	COG4807	Protein conserved in bacteria
LPY96_RS22065	COG1643	Atp-dependent helicase
LPY96_RS22080	COG1187	pseudouridine synthase activity
LPY96_RS22095	COG2130	NADP-dependent
LPY96_RS22125	COG1764	response to oxidative stress
LPY96_RS22130	COG1846	Transcriptional regulator
LPY96_RS22135	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LPY96_RS22145	COG0697	spore germination
LPY96_RS22215	COG1960	acyl-CoA dehydrogenase activity
LPY96_RS22220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LPY96_RS22225	COG4770	biotin carboxylase activity
LPY96_RS22255	COG2224	Isocitrate lyase
LPY96_RS22260	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LPY96_RS22265	COG0583	DNA-binding transcription factor activity
LPY96_RS22270	COG0475	glutathione-regulated potassium exporter activity
LPY96_RS22300	COG0339	signal peptide processing
LPY96_RS22305	COG1446	asparaginase
LPY96_RS22325	COG0564	pseudouridine synthase activity
LPY96_RS22335	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LPY96_RS22345	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPY96_RS22365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPY96_RS22375	COG0318	PFAM AMP-dependent synthetase and ligase
LPY96_RS22380	COG0727	PFAM Uncharacterised protein family (UPF0153)
LPY96_RS22385	COG0596	Alpha beta hydrolase
LPY96_RS22395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPY96_RS22410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LPY96_RS22435	COG2205	protein histidine kinase activity
LPY96_RS22440	COG0028	Belongs to the TPP enzyme family
LPY96_RS22455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LPY96_RS22460	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LPY96_RS22465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPY96_RS22500	COG0183	Belongs to the thiolase family
LPY96_RS22515	COG2032	superoxide dismutase activity
LPY96_RS22520	COG2032	superoxide dismutase activity
LPY96_RS22525	COG2204	response regulator
LPY96_RS22530	COG3852	Histidine kinase
LPY96_RS22535	COG0004	ammonium transporteR
LPY96_RS22540	COG0347	Belongs to the P(II) protein family
LPY96_RS22545	COG0174	glutamine synthetase
LPY96_RS22550	COG1968	undecaprenyl-diphosphatase activity
LPY96_RS22560	COG1881	PFAM PEBP family protein
LPY96_RS22590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPY96_RS22600	COG2062	phosphohistidine phosphatase, SixA
LPY96_RS22605	COG0489	protein tyrosine kinase activity
LPY96_RS22625	COG1396	sequence-specific DNA binding
LPY96_RS22645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LPY96_RS22660	COG1125	glycine betaine transport
LPY96_RS22675	COG1119	ATPase activity
LPY96_RS22685	COG1752	Esterase of the alpha-beta hydrolase superfamily
LPY96_RS22695	COG1522	sequence-specific DNA binding
LPY96_RS22700	COG3186	Phenylalanine-4-hydroxylase
LPY96_RS22715	COG2755	lipolytic protein G-D-S-L family
LPY96_RS22725	COG1028	Short-chain dehydrogenase reductase Sdr
LPY96_RS22730	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LPY96_RS22735	COG1609	Transcriptional regulator
LPY96_RS22740	COG3507	Belongs to the glycosyl hydrolase 43 family
LPY96_RS22755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LPY96_RS22810	COG2911	Protein conserved in bacteria
LPY96_RS22815	COG0729	surface antigen
LPY96_RS22820	COG4771	TonB-dependent receptor
LPY96_RS22825	COG0457	Tetratricopeptide repeat
LPY96_RS22835	COG0752	glycyl-tRNA synthetase alpha subunit
LPY96_RS22840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPY96_RS22850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPY96_RS22850	COG0519	Catalyzes the synthesis of GMP from XMP
LPY96_RS22860	COG0805	protein transport
LPY96_RS22865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPY96_RS22870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPY96_RS22880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LPY96_RS22895	COG2974	May be involved in recombination
LPY96_RS22900	COG0037	tRNA processing
LPY96_RS22905	COG2115	Belongs to the xylose isomerase family
LPY96_RS22915	COG3661	Belongs to the glycosyl hydrolase 67 family
LPY96_RS22925	COG4948	Mandelate Racemase Muconate Lactonizing
LPY96_RS22935	COG1472	Belongs to the glycosyl hydrolase 3 family
LPY96_RS22940	COG0246	Mannitol dehydrogenase
LPY96_RS22990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LPY96_RS23025	COG3250	beta-galactosidase activity
LPY96_RS23030	COG1904	glucuronate isomerase
LPY96_RS23050	COG3693	PFAM glycoside hydrolase, family 10
LPY96_RS23065	COG2211	Major facilitator Superfamily
LPY96_RS23145	COG2937	Belongs to the GPAT DAPAT family
LPY96_RS23175	COG0284	orotidine-5'-phosphate decarboxylase activity
LPY96_RS23180	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LPY96_RS23185	COG3132	Protein of unknown function, DUF480
LPY96_RS23200	COG0210	DNA helicase
LPY96_RS23205	COG1435	thymidine kinase activity
LPY96_RS23215	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LPY96_RS23225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPY96_RS23255	COG3135	benzoate transporter
LPY96_RS23275	COG0676	glucose-6-phosphate 1-epimerase activity
LPY96_RS23285	COG3012	SEC-C Motif Domain Protein
LPY96_RS23290	COG0730	response to heat
LPY96_RS23310	COG0302	gtp cyclohydrolase
LPY96_RS23325	COG1566	PFAM secretion protein HlyD family protein
LPY96_RS23335	COG1289	transmembrane transporter activity
LPY96_RS23340	COG0477	Major facilitator Superfamily
LPY96_RS23350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPY96_RS23370	COG4691	Plasmid stability protein
LPY96_RS23380	COG1487	ribonuclease activity
LPY96_RS23420	COG0439	Biotin carboxylase
LPY96_RS23460	COG1074	ATP-dependent DNA helicase activity
LPY96_RS23465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LPY96_RS23480	COG1127	ABC transporter
LPY96_RS23485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPY96_RS23490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPY96_RS23505	COG2853	Lipoprotein
LPY96_RS23515	COG0386	Belongs to the glutathione peroxidase family
LPY96_RS23525	COG1322	Protein conserved in bacteria
LPY96_RS23530	COG0604	alcohol dehydrogenase
LPY96_RS23535	COG0583	DNA-binding transcription factor activity
LPY96_RS23545	COG0625	glutathione transferase activity
LPY96_RS23555	COG0531	amino acid
LPY96_RS23570	COG3706	GGDEF domain
LPY96_RS23600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPY96_RS23605	COG0861	Integral membrane protein TerC family
LPY96_RS23615	COG0584	glycerophosphoryl diester phosphodiesterase
LPY96_RS23630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPY96_RS23635	COG0726	polysaccharide deacetylase
LPY96_RS23640	COG0706	membrane insertase activity
LPY96_RS23645	COG0594	ribonuclease P activity