locus-tag	class	description
GH913_RS00020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GH913_RS00025	COG0473	3-isopropylmalate dehydrogenase activity
GH913_RS00030	COG0066	3-isopropylmalate dehydratase activity
GH913_RS00035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GH913_RS00055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GH913_RS00060	COG1538	Outer membrane efflux protein
GH913_RS00065	COG1519	Transferase
GH913_RS00070	COG1560	Kdo2-lipid A biosynthetic process
GH913_RS00095	COG0281	malic enzyme
GH913_RS00095	COG0280	phosphate acetyltransferase
GH913_RS00100	COG1301	dicarboxylic acid transport
GH913_RS00125	COG0583	DNA-binding transcription factor activity
GH913_RS00130	COG0667	Aldo Keto reductase
GH913_RS00145	COG2197	response regulator
GH913_RS00155	COG0642	Histidine kinase
GH913_RS00170	COG2851	Citrate transporter
GH913_RS00175	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS00180	COG1609	Transcriptional regulator
GH913_RS00185	COG2211	Major facilitator Superfamily
GH913_RS00210	COG1162	GTPase activity
GH913_RS00275	COG4773	Receptor
GH913_RS00280	COG0726	polysaccharide deacetylase
GH913_RS00285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GH913_RS00300	COG3964	amidohydrolase
GH913_RS00305	COG0402	S-adenosylhomocysteine deaminase activity
GH913_RS00325	COG1307	EDD domain protein, DegV family
GH913_RS00330	COG0242	peptide deformylase activity
GH913_RS00350	COG0457	Tetratricopeptide repeat
GH913_RS00355	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GH913_RS00360	COG1215	transferase activity, transferring glycosyl groups
GH913_RS00365	COG1215	transferase activity, transferring glycosyl groups
GH913_RS00380	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GH913_RS00425	COG2188	Transcriptional regulator
GH913_RS00440	COG1450	Type ii and iii secretion system protein
GH913_RS00455	COG3166	PFAM Fimbrial assembly family protein
GH913_RS00460	COG3156	type II secretion system protein K
GH913_RS00465	COG4795	General secretion pathway protein
GH913_RS00470	COG2165	general secretion pathway protein
GH913_RS00475	COG4970	Tfp pilus assembly protein FimT
GH913_RS00480	COG2165	general secretion pathway protein
GH913_RS00485	COG1459	type II secretion system
GH913_RS00490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GH913_RS00495	COG1404	Belongs to the peptidase S8 family
GH913_RS00500	COG5295	Hep Hag repeat protein
GH913_RS00510	COG1404	Belongs to the peptidase S8 family
GH913_RS00520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GH913_RS00520	COG0047	phosphoribosylformylglycinamidine synthase activity
GH913_RS00525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GH913_RS00530	COG4974	Belongs to the 'phage' integrase family
GH913_RS00545	COG0795	lipopolysaccharide-transporting ATPase activity
GH913_RS00555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GH913_RS00570	COG0525	valine-tRNA ligase activity
GH913_RS00600	COG1183	phosphatidylcholine synthase activity
GH913_RS00610	COG0442	prolyl-tRNA aminoacylation
GH913_RS00625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GH913_RS00630	COG1127	ABC transporter
GH913_RS00635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GH913_RS00635	COG3218	ABC-type transport auxiliary lipoprotein component
GH913_RS00665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GH913_RS00670	COG0662	Cupin 2, conserved barrel domain protein
GH913_RS00670	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GH913_RS00700	COG2086	electron transfer activity
GH913_RS00715	COG0463	Glycosyl transferase, family 2
GH913_RS00750	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GH913_RS00755	COG0438	transferase activity, transferring glycosyl groups
GH913_RS00775	COG0438	transferase activity, transferring glycosyl groups
GH913_RS00780	COG0626	cystathionine gamma-synthase activity
GH913_RS00810	COG0625	glutathione transferase activity
GH913_RS00825	COG0513	Belongs to the DEAD box helicase family
GH913_RS00835	COG4206	TonB-dependent receptor
GH913_RS00840	COG0720	synthase
GH913_RS00850	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GH913_RS00855	COG1956	GAF domain-containing protein
GH913_RS00865	COG2819	hydrolase of the alpha beta superfamily
GH913_RS00880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GH913_RS00885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH913_RS00900	COG0339	signal peptide processing
GH913_RS00955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GH913_RS00960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_RS00965	COG4591	ABC-type transport system involved in lipoprotein release permease component
GH913_RS00965	COG1136	(ABC) transporter
GH913_RS00970	COG0577	efflux transmembrane transporter activity
GH913_RS00975	COG0577	efflux transmembrane transporter activity
GH913_RS00990	COG4191	Histidine kinase
GH913_RS00995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GH913_RS01010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GH913_RS01015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GH913_RS01020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GH913_RS01025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GH913_RS01030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GH913_RS01035	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GH913_RS01045	COG0356	it plays a direct role in the translocation of protons across the membrane
GH913_RS01065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GH913_RS01075	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH913_RS01125	COG2011	ABC-type metal ion transport system permease component
GH913_RS01130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GH913_RS01135	COG0697	spore germination
GH913_RS01140	COG1666	GTP binding
GH913_RS01150	COG0784	Response regulator, receiver
GH913_RS01150	COG5002	protein histidine kinase activity
GH913_RS01150	COG2198	Histidine kinase
GH913_RS01170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GH913_RS01175	COG1187	pseudouridine synthase activity
GH913_RS01200	COG2205	protein histidine kinase activity
GH913_RS01200	COG2202	Pas domain
GH913_RS01220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GH913_RS01225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH913_RS01280	COG0842	Transport permease protein
GH913_RS01285	COG1131	(ABC) transporter
GH913_RS01290	COG0025	NhaP-type Na H and K H
GH913_RS01295	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GH913_RS01300	COG1573	uracil-dna glycosylase
GH913_RS01310	COG3384	dioxygenase
GH913_RS01320	COG0583	DNA-binding transcription factor activity
GH913_RS01330	COG0667	Aldo Keto reductase
GH913_RS01340	COG3590	peptidase
GH913_RS01360	COG0531	amino acid
GH913_RS01375	COG2972	Histidine kinase
GH913_RS01395	COG3685	Protein conserved in bacteria
GH913_RS01400	COG3546	catalase activity
GH913_RS01440	COG1271	oxidase subunit
GH913_RS01445	COG1294	oxidase, subunit
GH913_RS01460	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS01465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GH913_RS01485	COG1132	(ABC) transporter
GH913_RS01500	COG1063	alcohol dehydrogenase
GH913_RS01590	COG0583	DNA-binding transcription factor activity
GH913_RS01595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GH913_RS01640	COG0024	Methionine aminopeptidase
GH913_RS01665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GH913_RS01700	COG0582	viral genome integration into host DNA
GH913_RS01715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH913_RS01720	COG1490	D-aminoacyl-tRNA deacylase activity
GH913_RS01725	COG1560	Kdo2-lipid A biosynthetic process
GH913_RS01780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GH913_RS01780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GH913_RS01785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GH913_RS01790	COG0242	peptide deformylase activity
GH913_RS01795	COG1652	LysM domain
GH913_RS01800	COG0758	DNA mediated transformation
GH913_RS01820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GH913_RS01820	COG1754	DNA topoisomerase type I activity
GH913_RS01825	COG0009	L-threonylcarbamoyladenylate synthase
GH913_RS01840	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS01850	COG0616	signal peptide processing
GH913_RS01855	COG0534	Mate efflux family protein
GH913_RS01875	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GH913_RS01880	COG0625	glutathione transferase activity
GH913_RS01895	COG1252	NADH dehydrogenase
GH913_RS01900	COG2860	membrane
GH913_RS01905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH913_RS01910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GH913_RS01915	COG3437	response regulator, receiver
GH913_RS01920	COG2177	Part of the ABC transporter FtsEX involved in
GH913_RS01925	COG2884	Cell division ATP-binding protein ftsE
GH913_RS01935	COG3118	belongs to the thioredoxin family
GH913_RS01940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GH913_RS01945	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GH913_RS01950	COG0583	DNA-binding transcription factor activity
GH913_RS01975	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GH913_RS01975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GH913_RS01980	COG1473	amidohydrolase
GH913_RS01985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_RS01990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH913_RS02000	COG5383	Protein conserved in bacteria
GH913_RS02040	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GH913_RS02045	COG3023	N-Acetylmuramoyl-L-alanine amidase
GH913_RS02055	COG4948	Mandelate Racemase Muconate Lactonizing
GH913_RS02065	COG0531	amino acid
GH913_RS02080	COG4682	membrane
GH913_RS02085	COG2133	pyrroloquinoline quinone binding
GH913_RS02095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GH913_RS02100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GH913_RS02110	COG1610	YqeY-like protein
GH913_RS02115	COG1295	ribonuclease BN
GH913_RS02120	COG0358	DNA primase activity
GH913_RS02135	COG0109	protoheme IX farnesyltransferase activity
GH913_RS02165	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GH913_RS02180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GH913_RS02220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GH913_RS02225	COG0739	heme binding
GH913_RS02230	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GH913_RS02240	COG2211	Major facilitator Superfamily
GH913_RS02245	COG0708	Exodeoxyribonuclease III
GH913_RS02250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GH913_RS02260	COG1192	Involved in chromosome partitioning
GH913_RS02265	COG1475	DNA binding
GH913_RS02280	COG0463	Glycosyl transferase, family 2
GH913_RS02300	COG0756	dUTP diphosphatase activity
GH913_RS02305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GH913_RS02310	COG2003	Belongs to the UPF0758 family
GH913_RS02315	COG0018	arginyl-trna synthetase
GH913_RS02330	COG4221	oxidoreductase activity
GH913_RS02345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GH913_RS02350	COG1166	arginine decarboxylase activity
GH913_RS02355	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GH913_RS02390	COG0606	chelatase, subunit chli
GH913_RS02405	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GH913_RS02430	COG1690	Belongs to the RtcB family
GH913_RS02465	COG1090	epimerase
GH913_RS02475	COG0642	Histidine kinase
GH913_RS02500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GH913_RS02525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GH913_RS02530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GH913_RS02545	COG0753	catalase activity
GH913_RS02560	COG2197	response regulator
GH913_RS02565	COG4585	Histidine kinase
GH913_RS02570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_RS02575	COG1136	(ABC) transporter
GH913_RS02600	COG0697	spore germination
GH913_RS02615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH913_RS02620	COG0180	Tryptophanyl-tRNA synthetase
GH913_RS02625	COG3237	CsbD-like
GH913_RS02665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GH913_RS02695	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GH913_RS02700	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GH913_RS02700	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GH913_RS02740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GH913_RS02760	COG1199	ATP-dependent helicase activity
GH913_RS02775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GH913_RS02850	COG0625	glutathione transferase activity
GH913_RS02885	COG4555	ABC transporter
GH913_RS02895	COG1476	TRANSCRIPTIONal
GH913_RS02940	COG0633	Ferredoxin
GH913_RS02940	COG0543	2 iron, 2 sulfur cluster binding
GH913_RS02945	COG1131	(ABC) transporter
GH913_RS02950	COG0842	Transport permease protein
GH913_RS02960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GH913_RS02995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GH913_RS03000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GH913_RS03010	COG1042	CoA-binding domain protein
GH913_RS03010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GH913_RS03010	COG0045	succinate-CoA ligase (ADP-forming) activity
GH913_RS03015	COG2239	Acts as a magnesium transporter
GH913_RS03030	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GH913_RS03035	COG3387	PFAM Glycoside hydrolase 15-related
GH913_RS03050	COG3100	YcgL domain-containing protein
GH913_RS03055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH913_RS03065	COG0463	Glycosyl transferase, family 2
GH913_RS03085	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS03125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH913_RS03140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH913_RS03160	COG4946	Tricorn protease homolog
GH913_RS03160	COG1506	peptidase
GH913_RS03160	COG0823	Involved in the tonB-independent uptake of proteins
GH913_RS03175	COG0408	coproporphyrinogen oxidase activity
GH913_RS03210	COG0515	serine threonine protein kinase
GH913_RS03210	COG2815	serine threonine protein kinase
GH913_RS03215	COG0631	protein serine/threonine phosphatase activity
GH913_RS03390	COG0210	DNA helicase
GH913_RS03400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_RS03405	COG0583	DNA-binding transcription factor activity
GH913_RS03410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GH913_RS03420	COG2159	amidohydrolase
GH913_RS03445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_RS03465	COG0357	Ribosomal RNA small subunit methyltransferase G
GH913_RS03470	COG3540	Alkaline phosphatase
GH913_RS03480	COG2091	lysine biosynthetic process via aminoadipic acid
GH913_RS03495	COG0708	Exodeoxyribonuclease III
GH913_RS03500	COG1940	carbohydrate kinase activity
GH913_RS03500	COG1846	Transcriptional regulator
GH913_RS03510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GH913_RS03520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GH913_RS03525	COG3162	membrane
GH913_RS03535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH913_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS03585	COG0179	Fumarylacetoacetate (FAA) hydrolase
GH913_RS03590	COG4948	Mandelate Racemase Muconate Lactonizing
GH913_RS03595	COG3254	rhamnose metabolic process
GH913_RS03600	COG0738	Major facilitator superfamily
GH913_RS03605	COG1414	Transcriptional regulator
GH913_RS03615	COG1971	Probably functions as a manganese efflux pump
GH913_RS03620	COG2205	protein histidine kinase activity
GH913_RS03630	COG3459	Glycosyltransferase 36 associated
GH913_RS03635	COG2211	Major facilitator Superfamily
GH913_RS03640	COG3265	gluconokinase activity
GH913_RS03645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH913_RS03675	COG1192	Involved in chromosome partitioning
GH913_RS03700	COG3077	Addiction module antitoxin, RelB DinJ family
GH913_RS03705	COG3041	Addiction module toxin RelE StbE family
GH913_RS03785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_RS03805	COG2948	multi-organism process
GH913_RS03810	COG3504	Conjugal transfer protein
GH913_RS03970	COG2948	multi-organism process
GH913_RS03975	COG3504	Conjugal transfer protein
GH913_RS03985	COG3704	protein secretion by the type IV secretion system
GH913_RS04090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH913_RS04135	COG0714	Associated with various cellular activities
GH913_RS04165	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GH913_RS04175	COG4772	TonB-dependent receptor
GH913_RS04185	COG0662	Cupin 2, conserved barrel domain protein
GH913_RS04235	COG1304	FMN binding
GH913_RS04245	COG4585	Histidine kinase
GH913_RS04250	COG2197	response regulator
GH913_RS04270	COG3710	Transcriptional regulator
GH913_RS04275	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GH913_RS04330	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS04335	COG0300	oxidoreductase activity
GH913_RS04355	COG1272	protein, Hemolysin III
GH913_RS04360	COG1111	helicase
GH913_RS04360	COG1205	dead DEAH box helicase
GH913_RS04445	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GH913_RS04470	COG1132	(ABC) transporter
GH913_RS04500	COG0367	asparagine synthase
GH913_RS04520	COG0438	transferase activity, transferring glycosyl groups
GH913_RS04520	COG0297	glycogen (starch) synthase activity
GH913_RS04525	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GH913_RS04540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GH913_RS04585	COG0069	glutamate synthase activity
GH913_RS04585	COG0067	glutamate synthase
GH913_RS04585	COG0070	glutamate synthase
GH913_RS04590	COG0493	'glutamate synthase
GH913_RS04605	COG1064	alcohol dehydrogenase
GH913_RS04610	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GH913_RS04615	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GH913_RS04625	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GH913_RS04635	COG2234	aminopeptidase activity
GH913_RS04645	COG4942	peptidase
GH913_RS04650	COG0793	Belongs to the peptidase S41A family
GH913_RS04735	COG2003	Belongs to the UPF0758 family
GH913_RS04770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_RS04780	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GH913_RS04810	COG0501	Belongs to the peptidase M48B family
GH913_RS04820	COG0187	DNA topoisomerase II activity
GH913_RS04825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GH913_RS04835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GH913_RS04845	COG0594	ribonuclease P activity
GH913_RS04850	COG0706	membrane insertase activity
GH913_RS04855	COG0726	polysaccharide deacetylase
GH913_RS04860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GH913_RS04875	COG0584	glycerophosphoryl diester phosphodiesterase
GH913_RS04885	COG0861	Integral membrane protein TerC family
GH913_RS04890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GH913_RS04915	COG3706	GGDEF domain
GH913_RS04925	COG3537	Alpha-1,2-mannosidase
GH913_RS04930	COG0531	amino acid
GH913_RS04940	COG0625	glutathione transferase activity
GH913_RS04950	COG0583	DNA-binding transcription factor activity
GH913_RS04955	COG0604	alcohol dehydrogenase
GH913_RS04960	COG1322	Protein conserved in bacteria
GH913_RS04970	COG0386	Belongs to the glutathione peroxidase family
GH913_RS04980	COG2853	Lipoprotein
GH913_RS04995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GH913_RS05000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GH913_RS05005	COG1127	ABC transporter
GH913_RS05020	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GH913_RS05025	COG1074	ATP-dependent DNA helicase activity
GH913_RS05065	COG0439	Biotin carboxylase
GH913_RS05120	COG4691	Plasmid stability protein
GH913_RS05140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_RS05150	COG0477	Major facilitator Superfamily
GH913_RS05155	COG1289	transmembrane transporter activity
GH913_RS05165	COG1566	PFAM secretion protein HlyD family protein
GH913_RS05180	COG0302	gtp cyclohydrolase
GH913_RS05200	COG0730	response to heat
GH913_RS05205	COG3012	SEC-C Motif Domain Protein
GH913_RS05215	COG0676	glucose-6-phosphate 1-epimerase activity
GH913_RS05235	COG3135	benzoate transporter
GH913_RS05265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GH913_RS05275	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GH913_RS05285	COG1435	thymidine kinase activity
GH913_RS05290	COG0210	DNA helicase
GH913_RS05305	COG3132	Protein of unknown function, DUF480
GH913_RS05310	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GH913_RS05315	COG0284	orotidine-5'-phosphate decarboxylase activity
GH913_RS05345	COG2937	Belongs to the GPAT DAPAT family
GH913_RS05425	COG2211	Major facilitator Superfamily
GH913_RS05440	COG3693	PFAM glycoside hydrolase, family 10
GH913_RS05455	COG1904	glucuronate isomerase
GH913_RS05460	COG3250	beta-galactosidase activity
GH913_RS05470	COG3386	PFAM SMP-30 Gluconolaconase
GH913_RS05495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GH913_RS05545	COG0246	Mannitol dehydrogenase
GH913_RS05550	COG1472	Belongs to the glycosyl hydrolase 3 family
GH913_RS05560	COG4948	Mandelate Racemase Muconate Lactonizing
GH913_RS05570	COG3661	Belongs to the glycosyl hydrolase 67 family
GH913_RS05580	COG2115	Belongs to the xylose isomerase family
GH913_RS05585	COG0037	tRNA processing
GH913_RS05590	COG2974	May be involved in recombination
GH913_RS05605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GH913_RS05615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GH913_RS05620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GH913_RS05625	COG0805	protein transport
GH913_RS05635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GH913_RS05635	COG0519	Catalyzes the synthesis of GMP from XMP
GH913_RS05645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GH913_RS05650	COG0752	glycyl-tRNA synthetase alpha subunit
GH913_RS05660	COG0457	Tetratricopeptide repeat
GH913_RS05665	COG4771	TonB-dependent receptor
GH913_RS05670	COG0729	surface antigen
GH913_RS05675	COG2911	Protein conserved in bacteria
GH913_RS05720	COG0657	acetylesterase activity
GH913_RS05720	COG2755	lipolytic protein G-D-S-L family
GH913_RS05730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH913_RS05745	COG3507	Belongs to the glycosyl hydrolase 43 family
GH913_RS05750	COG1609	Transcriptional regulator
GH913_RS05755	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GH913_RS05760	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS05770	COG2755	lipolytic protein G-D-S-L family
GH913_RS05785	COG3186	Phenylalanine-4-hydroxylase
GH913_RS05790	COG1522	sequence-specific DNA binding
GH913_RS05800	COG1752	Esterase of the alpha-beta hydrolase superfamily
GH913_RS05810	COG1119	ATPase activity
GH913_RS05825	COG1125	glycine betaine transport
GH913_RS05840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GH913_RS05860	COG1396	sequence-specific DNA binding
GH913_RS05880	COG0489	protein tyrosine kinase activity
GH913_RS05885	COG2062	phosphohistidine phosphatase, SixA
GH913_RS05895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_RS05925	COG1881	PFAM PEBP family protein
GH913_RS05935	COG1968	undecaprenyl-diphosphatase activity
GH913_RS05940	COG0174	glutamine synthetase
GH913_RS05945	COG0347	Belongs to the P(II) protein family
GH913_RS05950	COG0004	ammonium transporteR
GH913_RS05955	COG3852	Histidine kinase
GH913_RS05960	COG2204	response regulator
GH913_RS05965	COG2032	superoxide dismutase activity
GH913_RS05970	COG2032	superoxide dismutase activity
GH913_RS05985	COG0183	Belongs to the thiolase family
GH913_RS06020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GH913_RS06025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GH913_RS06030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GH913_RS06045	COG0028	Belongs to the TPP enzyme family
GH913_RS06050	COG2205	protein histidine kinase activity
GH913_RS06075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GH913_RS06090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH913_RS06100	COG0596	Alpha beta hydrolase
GH913_RS06105	COG0727	PFAM Uncharacterised protein family (UPF0153)
GH913_RS06110	COG0318	PFAM AMP-dependent synthetase and ligase
GH913_RS06120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH913_RS06130	COG1181	Belongs to the D-alanine--D-alanine ligase family
GH913_RS06140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH913_RS06150	COG0564	pseudouridine synthase activity
GH913_RS06170	COG1446	asparaginase
GH913_RS06175	COG0339	signal peptide processing
GH913_RS06200	COG0475	glutathione-regulated potassium exporter activity
GH913_RS06205	COG0583	DNA-binding transcription factor activity
GH913_RS06210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GH913_RS06215	COG2224	Isocitrate lyase
GH913_RS06245	COG4770	biotin carboxylase activity
GH913_RS06250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH913_RS06255	COG1960	acyl-CoA dehydrogenase activity
GH913_RS06325	COG0697	spore germination
GH913_RS06335	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GH913_RS06340	COG1846	Transcriptional regulator
GH913_RS06345	COG1764	response to oxidative stress
GH913_RS06375	COG2130	NADP-dependent
GH913_RS06390	COG1187	pseudouridine synthase activity
GH913_RS06405	COG1643	Atp-dependent helicase
GH913_RS06410	COG4807	Protein conserved in bacteria
GH913_RS06415	COG2351	hydroxyisourate hydrolase activity
GH913_RS06420	COG2072	flavoprotein involved in K transport
GH913_RS06440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GH913_RS06475	COG1957	nucleoside hydrolase
GH913_RS06485	COG2252	PERMEase
GH913_RS06505	COG0084	hydrolase, TatD family'
GH913_RS06535	COG2814	Major facilitator Superfamily
GH913_RS06550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GH913_RS06555	COG1902	pentaerythritol trinitrate reductase activity
GH913_RS06575	COG0745	RESPONSE REGULATOR receiver
GH913_RS06580	COG2205	protein histidine kinase activity
GH913_RS06585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_RS06610	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GH913_RS06615	COG0583	DNA-binding transcription factor activity
GH913_RS06645	COG0702	epimerase
GH913_RS06650	COG1733	regulation of RNA biosynthetic process
GH913_RS06710	COG0129	dihydroxy-acid dehydratase activity
GH913_RS06725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GH913_RS06775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GH913_RS06780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GH913_RS06805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GH913_RS06810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GH913_RS06825	COG3485	protocatechuate 3,4-dioxygenase
GH913_RS06835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GH913_RS06840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GH913_RS06850	COG1414	Transcriptional regulator
GH913_RS06870	COG0445	tRNA wobble uridine modification
GH913_RS06880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GH913_RS06910	COG2267	carboxylic ester hydrolase activity
GH913_RS06920	COG0156	8-amino-7-oxononanoate synthase activity
GH913_RS06925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GH913_RS06930	COG1040	competence protein
GH913_RS06935	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GH913_RS07005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GH913_RS07075	COG1511	domain protein
GH913_RS07075	COG3264	Mechanosensitive ion channel
GH913_RS07080	COG1368	sulfuric ester hydrolase activity
GH913_RS07085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH913_RS07090	COG2354	Protein conserved in bacteria
GH913_RS07100	COG0297	glycogen (starch) synthase activity
GH913_RS07105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GH913_RS07110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GH913_RS07135	COG0702	epimerase
GH913_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS07170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH913_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS07185	COG0513	Belongs to the DEAD box helicase family
GH913_RS07190	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH913_RS07205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GH913_RS07215	COG3483	tryptophan 2,3-dioxygenase activity
GH913_RS07220	COG3104	oligopeptide transport
GH913_RS07240	COG2852	Protein conserved in bacteria
GH913_RS07245	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GH913_RS07260	COG1320	monovalent cation:proton antiporter activity
GH913_RS07265	COG2212	antiporter activity
GH913_RS07275	COG0651	ATP synthesis coupled electron transport
GH913_RS07280	COG1006	Multisubunit Na H antiporter MnhC subunit
GH913_RS07285	COG2111	Na H antiporter
GH913_RS07285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GH913_RS07305	COG3179	chitinase
GH913_RS07325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GH913_RS07330	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GH913_RS07345	COG0456	acetyltransferase
GH913_RS07350	COG1597	lipid kinase activity
GH913_RS07375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GH913_RS07380	COG0134	indole-3-glycerol-phosphate synthase activity
GH913_RS07390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH913_RS07395	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GH913_RS07405	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GH913_RS07415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GH913_RS07430	COG1051	belongs to the nudix hydrolase family
GH913_RS07470	COG0316	Belongs to the HesB IscA family
GH913_RS07485	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GH913_RS07500	COG2814	Major facilitator Superfamily
GH913_RS07510	COG2814	Major facilitator Superfamily
GH913_RS07515	COG1289	transmembrane transporter activity
GH913_RS07525	COG0151	Belongs to the GarS family
GH913_RS07535	COG0138	bifunctional purine biosynthesis protein purh
GH913_RS07540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GH913_RS07545	COG2267	carboxylic ester hydrolase activity
GH913_RS07550	COG0671	phosphoesterase, PA-phosphatase related
GH913_RS07550	COG2453	phosphatase
GH913_RS07575	COG4589	Belongs to the CDS family
GH913_RS07580	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GH913_RS07605	COG2264	protein methyltransferase activity
GH913_RS07630	COG0439	Biotin carboxylase
GH913_RS07640	COG0511	ligase activity, forming carbon-carbon bonds
GH913_RS07645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GH913_RS07655	COG1324	tolerance protein
GH913_RS07680	COG0300	oxidoreductase activity
GH913_RS07685	COG2356	endonuclease I
GH913_RS07700	COG0459	protein refolding
GH913_RS07720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GH913_RS07735	COG3386	PFAM SMP-30 Gluconolaconase
GH913_RS07745	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GH913_RS07750	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GH913_RS07765	COG0778	Nitroreductase
GH913_RS07770	COG2353	YceI-like domain
GH913_RS07795	COG3052	prosthetic group binding
GH913_RS07825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GH913_RS07835	COG1802	Transcriptional regulator
GH913_RS07840	COG0546	phosphoglycolate phosphatase activity
GH913_RS07930	COG4221	oxidoreductase activity
GH913_RS07945	COG4221	oxidoreductase activity
GH913_RS07955	COG0435	Glutathione S-transferase
GH913_RS07985	COG2409	Drug exporters of the RND superfamily
GH913_RS07990	COG0823	Involved in the tonB-independent uptake of proteins
GH913_RS07990	COG1506	peptidase
GH913_RS08025	COG0697	spore germination
GH913_RS08040	COG1113	amino acid transport
GH913_RS08060	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GH913_RS08100	COG5001	Diguanylate cyclase
GH913_RS08105	COG0840	transmembrane signaling receptor activity
GH913_RS08110	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GH913_RS08110	COG5297	Belongs to the glycosyl hydrolase family 6
GH913_RS08115	COG0659	secondary active sulfate transmembrane transporter activity
GH913_RS08135	COG2943	transferase activity, transferring hexosyl groups
GH913_RS08145	COG3275	phosphorelay sensor kinase activity
GH913_RS08155	COG0181	hydroxymethylbilane synthase activity
GH913_RS08180	COG1505	serine-type exopeptidase activity
GH913_RS08190	COG0436	Aminotransferase
GH913_RS08200	COG2832	Protein of unknown function (DUF454)
GH913_RS08210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GH913_RS08220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GH913_RS08225	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GH913_RS08230	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GH913_RS08255	COG2226	methyltransferase
GH913_RS08260	COG5001	Diguanylate cyclase
GH913_RS08260	COG3300	MHYT domain
GH913_RS08265	COG0308	aminopeptidase N
GH913_RS08300	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GH913_RS08310	COG3284	Transcriptional regulator
GH913_RS08315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH913_RS08320	COG1077	Cell shape determining protein MreB Mrl
GH913_RS08325	COG1792	Involved in formation and maintenance of cell shape
GH913_RS08340	COG0772	Belongs to the SEDS family
GH913_RS08350	COG2951	lytic endotransglycosylase activity
GH913_RS08355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GH913_RS08360	COG1686	Belongs to the peptidase S11 family
GH913_RS08370	COG2921	Belongs to the UPF0250 family
GH913_RS08375	COG0321	lipoyl(octanoyl) transferase activity
GH913_RS08380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GH913_RS08395	COG0583	DNA-binding transcription factor activity
GH913_RS08405	COG1056	cytidyltransferase-related domain
GH913_RS08405	COG1051	belongs to the nudix hydrolase family
GH913_RS08440	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GH913_RS08445	COG0673	inositol 2-dehydrogenase activity
GH913_RS08450	COG2823	Periplasmic or secreted lipoprotein
GH913_RS08455	COG4251	negative regulation of phosphorylation
GH913_RS08460	COG0784	Response regulator, receiver
GH913_RS08465	COG4191	Histidine kinase
GH913_RS08470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GH913_RS08525	COG1459	type II secretion system
GH913_RS08545	COG4795	General secretion pathway protein
GH913_RS08575	COG3250	beta-galactosidase activity
GH913_RS08590	COG2188	Transcriptional regulator
GH913_RS08600	COG1609	Transcriptional regulator
GH913_RS08605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GH913_RS08610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GH913_RS08620	COG0617	tRNA 3'-terminal CCA addition
GH913_RS08625	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GH913_RS08630	COG1012	belongs to the aldehyde dehydrogenase family
GH913_RS08635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GH913_RS08650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GH913_RS08665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GH913_RS08685	COG2205	protein histidine kinase activity
GH913_RS08715	COG3791	Glutathione-dependent formaldehyde-activating
GH913_RS08730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH913_RS08740	COG0697	spore germination
GH913_RS08750	COG0488	(ABC) transporter
GH913_RS08760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GH913_RS08765	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GH913_RS08775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH913_RS08775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH913_RS08800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GH913_RS08805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GH913_RS08810	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GH913_RS08830	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GH913_RS08835	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GH913_RS08840	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GH913_RS08860	COG0745	RESPONSE REGULATOR receiver
GH913_RS08870	COG0277	FAD linked oxidase domain protein
GH913_RS08875	COG1988	membrane-bound metal-dependent
GH913_RS08880	COG0792	nuclease activity
GH913_RS08920	COG0275	rRNA processing
GH913_RS08925	COG3116	cell division
GH913_RS08935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GH913_RS08940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GH913_RS08945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GH913_RS08955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GH913_RS08960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GH913_RS08965	COG1181	Belongs to the D-alanine--D-alanine ligase family
GH913_RS08970	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GH913_RS08985	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GH913_RS08995	COG0739	heme binding
GH913_RS09000	COG0653	protein targeting
GH913_RS09005	COG0494	nUDIX hydrolase
GH913_RS09015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GH913_RS09025	COG0604	alcohol dehydrogenase
GH913_RS09025	COG3321	synthase
GH913_RS09025	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS09045	COG0366	Alpha amylase catalytic
GH913_RS09075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GH913_RS09085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GH913_RS09125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GH913_RS09135	COG4106	trans-aconitate 2-methyltransferase activity
GH913_RS09140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GH913_RS09150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH913_RS09155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GH913_RS09160	COG0667	Aldo Keto reductase
GH913_RS09170	COG4771	TonB-dependent receptor
GH913_RS09190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH913_RS09195	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GH913_RS09205	COG2175	clavaminate synthase activity
GH913_RS09215	COG4181	ATPase activity
GH913_RS09240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GH913_RS09260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GH913_RS09265	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GH913_RS09280	COG3829	transcription factor binding
GH913_RS09290	COG1116	anion transmembrane transporter activity
GH913_RS09295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH913_RS09305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH913_RS09310	COG0431	NADPH-dependent FMN reductase
GH913_RS09335	COG0747	negative chemotaxis
GH913_RS09355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GH913_RS09360	COG2967	ApaG domain
GH913_RS09365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GH913_RS09370	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GH913_RS09375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GH913_RS09380	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GH913_RS09395	COG0123	including yeast histone deacetylase and acetoin utilization protein
GH913_RS09400	COG2096	Adenosyltransferase
GH913_RS09415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH913_RS09420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH913_RS09450	COG3384	dioxygenase
GH913_RS09455	COG0583	DNA-binding transcription factor activity
GH913_RS09460	COG0318	PFAM AMP-dependent synthetase and ligase
GH913_RS09470	COG1024	Enoyl-CoA hydratase
GH913_RS09490	COG3386	PFAM SMP-30 Gluconolaconase
GH913_RS09525	COG0697	spore germination
GH913_RS09530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GH913_RS09555	COG2197	response regulator
GH913_RS09565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH913_RS09575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GH913_RS09580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GH913_RS09585	COG0583	DNA-binding transcription factor activity
GH913_RS09590	COG3634	alkyl hydroperoxide reductase activity
GH913_RS09600	COG2890	protein-(glutamine-N5) methyltransferase activity
GH913_RS09620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GH913_RS09620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GH913_RS09650	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GH913_RS09675	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GH913_RS09690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GH913_RS09705	COG1404	Belongs to the peptidase S8 family
GH913_RS09710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GH913_RS09735	COG1295	ribonuclease BN
GH913_RS09740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH913_RS09745	COG1254	Belongs to the acylphosphatase family
GH913_RS09760	COG0521	Mo-molybdopterin cofactor biosynthetic process
GH913_RS09770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GH913_RS09775	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GH913_RS09785	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GH913_RS09790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GH913_RS09800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GH913_RS09805	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GH913_RS09810	COG0193	aminoacyl-tRNA hydrolase activity
GH913_RS09815	COG0012	GTP binding
GH913_RS09835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GH913_RS09850	COG0250	Participates in transcription elongation, termination and antitermination
GH913_RS09855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GH913_RS09860	COG0081	regulation of translation
GH913_RS09865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GH913_RS09870	COG0222	ribosome binding
GH913_RS09875	COG0085	RNA polymerase activity
GH913_RS09880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GH913_RS09885	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GH913_RS09890	COG0049	tRNA binding
GH913_RS09895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GH913_RS09900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GH913_RS09905	COG0051	transcription antitermination factor activity, RNA binding
GH913_RS09910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GH913_RS09915	COG0088	Forms part of the polypeptide exit tunnel
GH913_RS09920	COG0089	rRNA binding
GH913_RS09925	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GH913_RS09930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GH913_RS09940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GH913_RS09945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GH913_RS09950	COG0255	Belongs to the universal ribosomal protein uL29 family
GH913_RS09955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GH913_RS09965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GH913_RS09970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GH913_RS09980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GH913_RS09985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GH913_RS09990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GH913_RS10000	COG1841	ribosomal large subunit assembly
GH913_RS10005	COG0200	Binds to the 23S rRNA
GH913_RS10010	COG0201	protein transport
GH913_RS10035	COG0203	ribosomal protein L17
GH913_RS10040	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GH913_RS10050	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GH913_RS10070	COG1217	gtp-binding protein TYPA
GH913_RS10075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GH913_RS10080	COG0039	L-malate dehydrogenase activity
GH913_RS10085	COG0625	glutathione transferase activity
GH913_RS10095	COG1902	pentaerythritol trinitrate reductase activity
GH913_RS10095	COG0446	pyridine nucleotide-disulphide oxidoreductase
GH913_RS10100	COG0604	alcohol dehydrogenase
GH913_RS10125	COG0156	8-amino-7-oxononanoate synthase activity
GH913_RS10130	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GH913_RS10135	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GH913_RS10140	COG4208	sulfate ABC transporter
GH913_RS10145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GH913_RS10155	COG1063	alcohol dehydrogenase
GH913_RS10185	COG0406	alpha-ribazole phosphatase activity
GH913_RS10195	COG0285	dihydrofolate synthase activity
GH913_RS10230	COG3291	Pkd domain containing protein
GH913_RS10240	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH913_RS10245	COG0671	phosphoesterase, PA-phosphatase related
GH913_RS10260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GH913_RS10275	COG4783	chaperone-mediated protein folding
GH913_RS10290	COG0473	3-isopropylmalate dehydrogenase activity
GH913_RS10325	COG3852	Histidine kinase
GH913_RS10335	COG0544	peptidyl-prolyl cis-trans isomerase activity
GH913_RS10345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GH913_RS10375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GH913_RS10385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH913_RS10395	COG0328	RNA-DNA hybrid ribonuclease activity
GH913_RS10400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GH913_RS10405	COG0631	protein serine/threonine phosphatase activity
GH913_RS10420	COG0859	PFAM glycosyl transferase family 9
GH913_RS10425	COG3642	lipopolysaccharide core region biosynthetic process
GH913_RS10430	COG1234	tRNA 3'-trailer cleavage
GH913_RS10435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GH913_RS10440	COG0315	cyclic pyranopterin monophosphate synthase activity
GH913_RS10445	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GH913_RS10450	COG0314	molybdopterin synthase activity
GH913_RS10580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GH913_RS10585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GH913_RS10590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GH913_RS10595	COG0537	adenosine 5'-monophosphoramidase activity
GH913_RS10615	COG0714	Associated with various cellular activities
GH913_RS10635	COG0424	maF-like protein
GH913_RS10640	COG1399	metal-binding, possibly nucleic acid-binding protein
GH913_RS10645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GH913_RS10650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH913_RS10665	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS10680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GH913_RS10685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GH913_RS10710	COG3829	transcription factor binding
GH913_RS10755	COG2373	Large extracellular alpha-helical protein
GH913_RS10770	COG4953	penicillin-binding protein 1C
GH913_RS10780	COG0678	peroxiredoxin activity
GH913_RS10800	COG0330	HflC and HflK could
GH913_RS10805	COG0330	HflC and HflK could
GH913_RS10815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GH913_RS10820	COG0308	aminopeptidase N
GH913_RS10825	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS10830	COG1309	transcriptional regulator
GH913_RS10875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GH913_RS10880	COG1196	nuclear chromosome segregation
GH913_RS10890	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GH913_RS10910	COG1309	transcriptional regulator
GH913_RS10920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GH913_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS10940	COG3537	Alpha-1,2-mannosidase
GH913_RS10945	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS10955	COG0492	ferredoxin-NADP+ reductase activity
GH913_RS10965	COG3287	FIST C domain
GH913_RS10965	COG2199	diguanylate cyclase activity
GH913_RS10965	COG2200	EAL domain
GH913_RS10980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GH913_RS10985	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GH913_RS10990	COG2080	2 iron, 2 sulfur cluster binding
GH913_RS11025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GH913_RS11040	COG0587	DNA-directed DNA polymerase activity
GH913_RS11060	COG1297	OPT oligopeptide transporter protein
GH913_RS11075	COG1506	peptidase
GH913_RS11075	COG0823	Involved in the tonB-independent uptake of proteins
GH913_RS11100	COG2207	Transcriptional regulator
GH913_RS11100	COG1917	Cupin 2, conserved barrel domain protein
GH913_RS11130	COG0753	catalase activity
GH913_RS11135	COG0656	L-ascorbic acid biosynthetic process
GH913_RS11145	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GH913_RS11145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GH913_RS11150	COG2814	Major facilitator Superfamily
GH913_RS11165	COG2194	sulfuric ester hydrolase activity
GH913_RS11180	COG0745	RESPONSE REGULATOR receiver
GH913_RS11185	COG0642	Histidine kinase
GH913_RS11195	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GH913_RS11200	COG2894	cell division
GH913_RS11205	COG0850	regulation of cytokinetic process
GH913_RS11215	COG4585	Histidine kinase
GH913_RS11220	COG2197	response regulator
GH913_RS11235	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GH913_RS11265	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GH913_RS11275	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GH913_RS11295	COG1946	Acyl-CoA thioesterase
GH913_RS11310	COG0824	Thioesterase
GH913_RS11315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GH913_RS11320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GH913_RS11325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GH913_RS11330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GH913_RS11335	COG0268	Binds directly to 16S ribosomal RNA
GH913_RS11340	COG0728	peptidoglycan biosynthetic process
GH913_RS11345	COG0196	riboflavin kinase activity
GH913_RS11350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GH913_RS11355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GH913_RS11360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GH913_RS11510	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GH913_RS11510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_RS11565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GH913_RS11570	COG1845	cytochrome c oxidase, subunit III
GH913_RS11575	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GH913_RS11590	COG3152	Membrane
GH913_RS11600	COG2207	Transcriptional regulator
GH913_RS11605	COG0326	Molecular chaperone. Has ATPase activity
GH913_RS11615	COG1366	Belongs to the anti-sigma-factor antagonist family
GH913_RS11620	COG1366	Belongs to the anti-sigma-factor antagonist family
GH913_RS11625	COG2172	sigma factor antagonist activity
GH913_RS11650	COG4771	TonB-dependent receptor
GH913_RS11660	COG5507	3-demethylubiquinone-9 3-methyltransferase
GH913_RS11675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GH913_RS11680	COG4999	Histidine kinase
GH913_RS11680	COG3850	Histidine kinase
GH913_RS11680	COG3437	response regulator, receiver
GH913_RS11680	COG2205	protein histidine kinase activity
GH913_RS11685	COG4191	Histidine kinase
GH913_RS11685	COG0784	Response regulator, receiver
GH913_RS11715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GH913_RS11720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GH913_RS11730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GH913_RS11735	COG0228	four-way junction DNA binding
GH913_RS11740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GH913_RS11745	COG0336	Belongs to the RNA methyltransferase TrmD family
GH913_RS11750	COG0335	large ribosomal subunit rRNA binding
GH913_RS11755	COG0534	Mate efflux family protein
GH913_RS11775	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GH913_RS11785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GH913_RS11840	COG3250	beta-galactosidase activity
GH913_RS11845	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GH913_RS11865	COG1960	acyl-CoA dehydrogenase activity
GH913_RS11890	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH913_RS11890	COG1024	Enoyl-CoA hydratase
GH913_RS11905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GH913_RS11910	COG0481	GTPase activity
GH913_RS11925	COG0571	ribonuclease III activity
GH913_RS11930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GH913_RS11935	COG1381	Involved in DNA repair and RecF pathway recombination
GH913_RS11945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GH913_RS11955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GH913_RS11960	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
GH913_RS11965	COG3046	protein related to deoxyribodipyrimidine photolyase
GH913_RS11970	COG1472	Belongs to the glycosyl hydrolase 3 family
GH913_RS11975	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GH913_RS11980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GH913_RS11985	COG1278	Cold shock
GH913_RS11990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH913_RS12000	COG1201	RNA secondary structure unwinding
GH913_RS12005	COG1793	dna ligase
GH913_RS12015	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GH913_RS12015	COG1793	dna ligase
GH913_RS12045	COG0183	Belongs to the thiolase family
GH913_RS12070	COG1451	nucleotide metabolic process
GH913_RS12075	COG5487	UPF0391 membrane protein
GH913_RS12085	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GH913_RS12100	COG1077	Cell shape determining protein MreB Mrl
GH913_RS12105	COG1047	Peptidyl-prolyl cis-trans
GH913_RS12115	COG2824	Alkylphosphonate utilization operon protein PhnA
GH913_RS12125	COG2814	Major facilitator Superfamily
GH913_RS12160	COG0392	lysyltransferase activity
GH913_RS12160	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GH913_RS12170	COG0251	oxidation-reduction process
GH913_RS12175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GH913_RS12190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GH913_RS12215	COG1595	DNA-templated transcription, initiation
GH913_RS12230	COG2878	Part of a membrane complex involved in electron transport
GH913_RS12240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH913_RS12240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH913_RS12255	COG1131	(ABC) transporter
GH913_RS12260	COG0346	lactoylglutathione lyase activity
GH913_RS12265	COG0833	amino acid
GH913_RS12270	COG2040	homocysteine
GH913_RS12280	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GH913_RS12300	COG1695	Transcriptional regulator
GH913_RS12320	COG1981	membrane
GH913_RS12335	COG0825	malonyl-CoA metabolic process
GH913_RS12345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GH913_RS12350	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH913_RS12355	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH913_RS12360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH913_RS12365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH913_RS12380	COG0750	zinc metalloprotease
GH913_RS12385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GH913_RS12390	COG0575	Belongs to the CDS family
GH913_RS12395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GH913_RS12400	COG0233	cytoplasmic translational termination
GH913_RS12405	COG0528	UMP kinase activity
GH913_RS12415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GH913_RS12420	COG0052	Belongs to the universal ribosomal protein uS2 family
GH913_RS12460	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GH913_RS12470	COG1393	Belongs to the ArsC family
GH913_RS12475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH913_RS12480	COG0367	asparagine synthase
GH913_RS12490	COG4774	siderophore transport
GH913_RS12505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GH913_RS12530	COG1566	PFAM secretion protein HlyD family protein
GH913_RS12535	COG2814	Major facilitator Superfamily
GH913_RS12585	COG0339	signal peptide processing
GH913_RS12590	COG0386	Belongs to the glutathione peroxidase family
GH913_RS12655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GH913_RS12660	COG0084	hydrolase, TatD family'
GH913_RS12675	COG1960	acyl-CoA dehydrogenase activity
GH913_RS12695	COG0367	asparagine synthase
GH913_RS12705	COG0305	Participates in initiation and elongation during chromosome replication
GH913_RS12710	COG0415	Belongs to the DNA photolyase family
GH913_RS12725	COG0583	DNA-binding transcription factor activity
GH913_RS12770	COG3706	GGDEF domain
GH913_RS12830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GH913_RS12845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH913_RS12855	COG0497	DNA recombination
GH913_RS12860	COG1420	regulation of RNA biosynthetic process
GH913_RS12865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GH913_RS12870	COG0443	Heat shock 70 kDa protein
GH913_RS12875	COG0484	heat shock protein binding
GH913_RS12915	COG0583	DNA-binding transcription factor activity
GH913_RS12920	COG1132	(ABC) transporter
GH913_RS12955	COG2850	peptidyl-arginine hydroxylation
GH913_RS12975	COG1253	flavin adenine dinucleotide binding
GH913_RS13005	COG1131	(ABC) transporter
GH913_RS13010	COG1725	Transcriptional regulator
GH913_RS13020	COG0386	Belongs to the glutathione peroxidase family
GH913_RS13035	COG2900	Belongs to the SlyX family
GH913_RS13060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH913_RS13070	COG0646	methionine synthase
GH913_RS13070	COG1410	methionine synthase
GH913_RS13075	COG0646	methionine synthase
GH913_RS13075	COG1410	methionine synthase
GH913_RS13080	COG2226	methyltransferase
GH913_RS13085	COG1960	acyl-CoA dehydrogenase activity
GH913_RS13090	COG1960	acyl-CoA dehydrogenase activity
GH913_RS13095	COG1960	acyl-CoA dehydrogenase activity
GH913_RS13110	COG0557	exoribonuclease II activity
GH913_RS13120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GH913_RS13130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GH913_RS13140	COG0704	Plays a role in the regulation of phosphate uptake
GH913_RS13145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GH913_RS13150	COG0581	inorganic phosphate transmembrane transporter activity
GH913_RS13155	COG0573	inorganic phosphate transmembrane transporter activity
GH913_RS13160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GH913_RS13185	COG0659	secondary active sulfate transmembrane transporter activity
GH913_RS13190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GH913_RS13200	COG1024	Enoyl-CoA hydratase
GH913_RS13210	COG0494	nUDIX hydrolase
GH913_RS13245	COG0488	(ABC) transporter
GH913_RS13255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GH913_RS13255	COG0116	Belongs to the methyltransferase superfamily
GH913_RS13260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GH913_RS13285	COG2925	Exonuclease
GH913_RS13290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH913_RS13295	COG3844	kynureninase activity
GH913_RS13305	COG0662	Cupin 2, conserved barrel domain protein
GH913_RS13310	COG0288	reversible hydration of carbon dioxide
GH913_RS13380	COG2808	Putative FMN-binding domain
GH913_RS13400	COG0017	Asparaginyl-tRNA synthetase
GH913_RS13405	COG0316	Belongs to the HesB IscA family
GH913_RS13410	COG0360	Binds together with S18 to 16S ribosomal RNA
GH913_RS13415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GH913_RS13420	COG0359	binds to the 23S rRNA
GH913_RS13430	COG3115	cell septum assembly
GH913_RS13445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GH913_RS13450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GH913_RS13455	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GH913_RS13465	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GH913_RS13475	COG4993	Dehydrogenase
GH913_RS13485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GH913_RS13495	COG2986	histidine ammonia-lyase
GH913_RS13500	COG1228	amidohydrolase
GH913_RS13535	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GH913_RS13540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GH913_RS13545	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GH913_RS13550	COG0077	Prephenate dehydratase
GH913_RS13550	COG1605	Chorismate mutase
GH913_RS13555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GH913_RS13570	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GH913_RS13575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GH913_RS13580	COG0583	DNA-binding transcription factor activity
GH913_RS13595	COG0840	transmembrane signaling receptor activity
GH913_RS13630	COG4191	Histidine kinase
GH913_RS13630	COG0784	Response regulator, receiver
GH913_RS13645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH913_RS13655	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GH913_RS13665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GH913_RS13680	COG1595	DNA-templated transcription, initiation
GH913_RS13715	COG2951	lytic endotransglycosylase activity
GH913_RS13785	COG2244	polysaccharide biosynthetic process
GH913_RS13815	COG2264	protein methyltransferase activity
GH913_RS13840	COG1136	(ABC) transporter
GH913_RS13845	COG1132	(ABC) transporter
GH913_RS13850	COG0477	Major facilitator Superfamily
GH913_RS13855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH913_RS13870	COG1253	flavin adenine dinucleotide binding
GH913_RS13880	COG0306	phosphate transporter
GH913_RS13905	COG0504	CTP synthase activity
GH913_RS13910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GH913_RS13920	COG0148	phosphopyruvate hydratase activity
GH913_RS13925	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GH913_RS13930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GH913_RS13935	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GH913_RS13940	COG0585	pseudouridine synthase activity
GH913_RS13950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GH913_RS13955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GH913_RS13960	COG1238	metal cluster binding
GH913_RS13975	COG1534	Rna-binding protein
GH913_RS13980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GH913_RS13990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GH913_RS13995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GH913_RS14005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GH913_RS14010	COG1546	Belongs to the CinA family
GH913_RS14020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GH913_RS14025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GH913_RS14030	COG2137	regulation of response to DNA damage stimulus
GH913_RS14035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GH913_RS14040	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GH913_RS14055	COG1741	Belongs to the pirin family
GH913_RS14060	COG0583	DNA-binding transcription factor activity
GH913_RS14085	COG0351	phosphomethylpyrimidine kinase
GH913_RS14100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GH913_RS14105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GH913_RS14120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH913_RS14130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GH913_RS14135	COG3734	2-keto-3-deoxy-galactonokinase
GH913_RS14145	COG4948	Mandelate Racemase Muconate Lactonizing
GH913_RS14150	COG0800	Aldolase
GH913_RS14185	COG1501	Belongs to the glycosyl hydrolase 31 family
GH913_RS14195	COG1070	Carbohydrate kinase
GH913_RS14200	COG2115	Belongs to the xylose isomerase family
GH913_RS14205	COG0477	Major facilitator Superfamily
GH913_RS14225	COG0860	N-Acetylmuramoyl-L-alanine amidase
GH913_RS14230	COG1469	GTP cyclohydrolase I activity
GH913_RS14250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GH913_RS14255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GH913_RS14260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GH913_RS14265	COG0166	Belongs to the GPI family
GH913_RS14285	COG1472	Belongs to the glycosyl hydrolase 3 family
GH913_RS14295	COG4251	negative regulation of phosphorylation
GH913_RS14295	COG3706	GGDEF domain
GH913_RS14295	COG2203	Gaf domain
GH913_RS14295	COG5001	Diguanylate cyclase
GH913_RS14300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GH913_RS14305	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GH913_RS14315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GH913_RS14320	COG0671	phosphoesterase, PA-phosphatase related
GH913_RS14335	COG1794	racemase activity, acting on amino acids and derivatives
GH913_RS14340	COG0697	spore germination
GH913_RS14345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GH913_RS14350	COG0167	dihydroorotate dehydrogenase activity
GH913_RS14365	COG1012	belongs to the aldehyde dehydrogenase family
GH913_RS14380	COG1215	transferase activity, transferring glycosyl groups
GH913_RS14385	COG0726	polysaccharide deacetylase
GH913_RS14385	COG1649	PFAM Uncharacterised BCR, COG1649
GH913_RS14435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GH913_RS14445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH913_RS14450	COG0124	histidyl-tRNA synthetase
GH913_RS14460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GH913_RS14465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GH913_RS14470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GH913_RS14475	COG0131	Imidazoleglycerol-phosphate dehydratase
GH913_RS14475	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GH913_RS14480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GH913_RS14485	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GH913_RS14490	COG0107	imidazoleglycerol-phosphate synthase activity
GH913_RS14495	COG0140	phosphoribosyl-ATP diphosphatase activity
GH913_RS14495	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GH913_RS14510	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GH913_RS14515	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GH913_RS14520	COG0235	Class ii aldolase
GH913_RS14525	COG0531	amino acid
GH913_RS14530	COG0531	amino acid
GH913_RS14540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GH913_RS14545	COG0277	FAD linked oxidase domain protein
GH913_RS14565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GH913_RS14610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH913_RS14615	COG2258	MOSC domain
GH913_RS14620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GH913_RS14625	COG0505	Belongs to the CarA family
GH913_RS14635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GH913_RS14640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GH913_RS14650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GH913_RS14685	COG3279	Response regulator of the LytR AlgR family
GH913_RS14695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GH913_RS14705	COG2205	protein histidine kinase activity
GH913_RS14705	COG0784	Response regulator, receiver
GH913_RS14705	COG2198	Histidine kinase
GH913_RS14710	COG1024	Enoyl-CoA hydratase
GH913_RS14715	COG0318	PFAM AMP-dependent synthetase and ligase
GH913_RS14745	COG2267	carboxylic ester hydrolase activity
GH913_RS14755	COG2201	protein-glutamate methylesterase activity
GH913_RS14760	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GH913_RS14770	COG0840	transmembrane signaling receptor activity
GH913_RS14780	COG0835	chemotaxis
GH913_RS14795	COG0840	transmembrane signaling receptor activity
GH913_RS14800	COG0840	transmembrane signaling receptor activity
GH913_RS14805	COG0840	transmembrane signaling receptor activity
GH913_RS14810	COG0840	transmembrane signaling receptor activity
GH913_RS14820	COG0840	transmembrane signaling receptor activity
GH913_RS14825	COG0840	transmembrane signaling receptor activity
GH913_RS14830	COG0840	transmembrane signaling receptor activity
GH913_RS14840	COG0840	transmembrane signaling receptor activity
GH913_RS14860	COG0840	transmembrane signaling receptor activity
GH913_RS14870	COG0745	RESPONSE REGULATOR receiver
GH913_RS14880	COG0835	chemotaxis
GH913_RS14890	COG1360	Flagellar Motor Protein
GH913_RS14895	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GH913_RS14910	COG1192	Involved in chromosome partitioning
GH913_RS14980	COG0643	Histidine kinase
GH913_RS14980	COG0784	Response regulator, receiver
GH913_RS14980	COG2198	Histidine kinase
GH913_RS15010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GH913_RS15035	COG1684	flagellar biosynthetic protein fliR
GH913_RS15050	COG3190	flagellar
GH913_RS15100	COG1677	Flagellar hook-basal body complex protein FliE
GH913_RS15145	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS15150	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS15155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH913_RS15175	COG2201	protein-glutamate methylesterase activity
GH913_RS15205	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GH913_RS15215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GH913_RS15220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GH913_RS15230	COG1705	Flagellar rod assembly protein muramidase FlgJ
GH913_RS15230	COG3951	Flagellar rod assembly protein muramidase FlgJ
GH913_RS15235	COG1706	bacterial-type flagellum-dependent cell motility
GH913_RS15240	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GH913_RS15250	COG4787	bacterial-type flagellum-dependent cell motility
GH913_RS15260	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GH913_RS15265	COG1558	bacterial-type flagellum-dependent cell motility
GH913_RS15275	COG0784	Response regulator, receiver
GH913_RS15275	COG0835	chemotaxis
GH913_RS15295	COG5002	protein histidine kinase activity
GH913_RS15325	COG2915	High frequency lysogenization protein hflD homolog
GH913_RS15330	COG0482	sulfurtransferase activity
GH913_RS15345	COG0542	response to heat
GH913_RS15355	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GH913_RS15365	COG0492	ferredoxin-NADP+ reductase activity
GH913_RS15370	COG1674	ftsk spoiiie
GH913_RS15380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GH913_RS15390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GH913_RS15395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GH913_RS15400	COG0183	Belongs to the thiolase family
GH913_RS15405	COG1024	Enoyl-CoA hydratase
GH913_RS15405	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH913_RS15420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GH913_RS15430	COG1426	Protein conserved in bacteria
GH913_RS15440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH913_RS15445	COG1160	GTP binding
GH913_RS15450	COG0303	'Molybdopterin
GH913_RS15455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GH913_RS15645	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GH913_RS15680	COG4644	lycopene metabolic process
GH913_RS15780	COG0708	Exodeoxyribonuclease III
GH913_RS15790	COG0303	'Molybdopterin
GH913_RS15795	COG0746	molybdenum cofactor guanylyltransferase activity
GH913_RS15805	COG1648	precorrin-2 dehydrogenase activity
GH913_RS15805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GH913_RS15830	COG3685	Protein conserved in bacteria
GH913_RS15850	COG3706	GGDEF domain
GH913_RS15850	COG5001	Diguanylate cyclase
GH913_RS15850	COG2203	Gaf domain
GH913_RS15850	COG4251	negative regulation of phosphorylation
GH913_RS15870	COG4566	intracellular signal transduction
GH913_RS15890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_RS15910	COG3279	Response regulator of the LytR AlgR family
GH913_RS15945	COG1238	metal cluster binding
GH913_RS16065	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GH913_RS16065	COG0316	Belongs to the HesB IscA family
GH913_RS16070	COG2154	pterin-4-alpha-carbinolamine dehydratase
GH913_RS16080	COG0428	transporter
GH913_RS16085	COG3064	Membrane
GH913_RS16095	COG1530	ribonuclease E activity
GH913_RS16105	COG1054	Belongs to the UPF0176 family
GH913_RS16125	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GH913_RS16375	COG0583	DNA-binding transcription factor activity
GH913_RS16380	COG0477	Major facilitator Superfamily
GH913_RS16395	COG1960	acyl-CoA dehydrogenase activity
GH913_RS16405	COG2816	NAD+ diphosphatase activity
GH913_RS16415	COG2814	Major facilitator Superfamily
GH913_RS16540	COG3593	DNA synthesis involved in DNA repair
GH913_RS16560	COG0583	DNA-binding transcription factor activity
GH913_RS16575	COG0582	viral genome integration into host DNA
GH913_RS16595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GH913_RS16600	COG0322	excinuclease ABC activity
GH913_RS16610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GH913_RS16615	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GH913_RS16620	COG1663	tetraacyldisaccharide 4'-kinase activity
GH913_RS16625	COG1132	(ABC) transporter
GH913_RS16635	COG0811	peptide transport
GH913_RS16650	COG1136	(ABC) transporter
GH913_RS16655	COG4591	ABC-type transport system involved in lipoprotein release permease component
GH913_RS16665	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GH913_RS16670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GH913_RS16685	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GH913_RS16710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GH913_RS16715	COG0837	glucose binding
GH913_RS16720	COG0363	glucosamine-6-phosphate deaminase activity
GH913_RS16725	COG0129	dihydroxy-acid dehydratase activity
GH913_RS16730	COG0800	Aldolase
GH913_RS16805	COG2205	protein histidine kinase activity
GH913_RS16805	COG0784	Response regulator, receiver
GH913_RS16815	COG2183	response to ionizing radiation
GH913_RS16825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH913_RS16825	COG0723	plastoquinol--plastocyanin reductase activity
GH913_RS16840	COG3243	poly(R)-hydroxyalkanoic acid synthase
GH913_RS16850	COG1183	phosphatidylcholine synthase activity
GH913_RS16855	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS16870	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GH913_RS16880	COG0668	transmembrane transport
GH913_RS16890	COG2814	Major facilitator Superfamily
GH913_RS16910	COG1914	H( )-stimulated, divalent metal cation uptake system
GH913_RS16925	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GH913_RS16935	COG1335	isochorismatase
GH913_RS16955	COG2197	response regulator
GH913_RS16975	COG0583	DNA-binding transcription factor activity
GH913_RS16980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GH913_RS16985	COG3002	Belongs to the UPF0753 family
GH913_RS17010	COG3846	protein secretion by the type IV secretion system
GH913_RS17025	COG3451	type IV secretory pathway VirB4
GH913_RS17070	COG0667	Aldo Keto reductase
GH913_RS17115	COG0582	viral genome integration into host DNA
GH913_RS17120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GH913_RS17120	COG0519	Catalyzes the synthesis of GMP from XMP
GH913_RS17130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GH913_RS17140	COG0475	glutathione-regulated potassium exporter activity
GH913_RS17140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GH913_RS17145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GH913_RS17155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GH913_RS17160	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GH913_RS17170	COG0776	regulation of translation
GH913_RS17175	COG0539	negative regulation of cytoplasmic translation
GH913_RS17180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GH913_RS17195	COG2957	Belongs to the agmatine deiminase family
GH913_RS17200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH913_RS17225	COG0395	ABC-type sugar transport system, permease component
GH913_RS17230	COG1175	transmembrane transport
GH913_RS17260	COG2350	Protein conserved in bacteria
GH913_RS17265	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GH913_RS17270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GH913_RS17275	COG1187	pseudouridine synthase activity
GH913_RS17295	COG0436	Aminotransferase
GH913_RS17300	COG4133	protoheme IX ABC transporter activity
GH913_RS17320	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GH913_RS17325	COG1138	Cytochrome C-type biogenesis protein
GH913_RS17345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GH913_RS17350	COG1278	Cold shock
GH913_RS17355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GH913_RS17360	COG4988	ABC transporter
GH913_RS17370	COG1294	oxidase, subunit
GH913_RS17395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GH913_RS17400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GH913_RS17410	COG0165	Argininosuccinate lyase
GH913_RS17415	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GH913_RS17425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GH913_RS17430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH913_RS17440	COG0137	argininosuccinate synthase activity
GH913_RS17445	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GH913_RS17455	COG0215	cysteine-tRNA ligase activity
GH913_RS17460	COG2166	iron-sulfur cluster assembly
GH913_RS17475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GH913_RS17480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GH913_RS17505	COG4302	ethanolamine ammonia-lyase activity
GH913_RS17565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GH913_RS17570	COG0402	S-adenosylhomocysteine deaminase activity
GH913_RS17580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GH913_RS17585	COG1509	lysine 2,3-aminomutase activity
GH913_RS17590	COG5001	Diguanylate cyclase
GH913_RS17590	COG3300	MHYT domain
GH913_RS17605	COG0483	inositol monophosphate 1-phosphatase activity
GH913_RS17610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GH913_RS17625	COG0488	(ABC) transporter
GH913_RS17630	COG0513	Belongs to the DEAD box helicase family
GH913_RS17635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GH913_RS17640	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GH913_RS17650	COG0625	glutathione transferase activity
GH913_RS17660	COG4681	YaeQ
GH913_RS17665	COG2081	HI0933 family
GH913_RS17675	COG0501	Belongs to the peptidase M48B family
GH913_RS17680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GH913_RS17685	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS17710	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GH913_RS17715	COG0860	N-Acetylmuramoyl-L-alanine amidase
GH913_RS17720	COG0802	atpase or kinase
GH913_RS17725	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GH913_RS17725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GH913_RS17730	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GH913_RS17735	COG1570	exodeoxyribonuclease VII activity
GH913_RS17745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GH913_RS17865	COG0835	chemotaxis
GH913_RS17870	COG0840	transmembrane signaling receptor activity
GH913_RS17875	COG2094	Belongs to the DNA glycosylase MPG family
GH913_RS17880	COG1201	RNA secondary structure unwinding
GH913_RS17900	COG2969	positive regulation of protein catabolic process
GH913_RS17905	COG0625	glutathione transferase activity
GH913_RS17910	COG2857	Cytochrome c1
GH913_RS17915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GH913_RS17920	COG0723	plastoquinol--plastocyanin reductase activity
GH913_RS17925	COG0741	lytic transglycosylase activity
GH913_RS17940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GH913_RS17945	COG1702	phosphate starvation-inducible protein PhoH
GH913_RS17955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GH913_RS17965	COG4535	Mg2 and Co2 transporter CorC
GH913_RS17980	COG1012	belongs to the aldehyde dehydrogenase family
GH913_RS17985	COG1177	transmembrane transport
GH913_RS17990	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH913_RS17995	COG3842	ATPase activity
GH913_RS18015	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GH913_RS18030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GH913_RS18035	COG0174	glutamine synthetase
GH913_RS18040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH913_RS18050	COG2703	oxygen carrier activity
GH913_RS18055	COG0477	Major facilitator Superfamily
GH913_RS18065	COG0243	molybdopterin cofactor binding
GH913_RS18070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GH913_RS18075	COG2223	nitrite transmembrane transporter activity
GH913_RS18085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GH913_RS18095	COG2733	membrane
GH913_RS18100	COG0784	Response regulator, receiver
GH913_RS18100	COG2205	protein histidine kinase activity
GH913_RS18100	COG5002	protein histidine kinase activity
GH913_RS18110	COG0477	Major facilitator Superfamily
GH913_RS18120	COG2902	Dehydrogenase
GH913_RS18130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_RS18135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH913_RS18140	COG1609	Transcriptional regulator
GH913_RS18145	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH913_RS18145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GH913_RS18150	COG1105	Belongs to the carbohydrate kinase PfkB family
GH913_RS18155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GH913_RS18155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GH913_RS18205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GH913_RS18215	COG1862	Preprotein translocase
GH913_RS18220	COG0343	queuine tRNA-ribosyltransferase activity
GH913_RS18225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GH913_RS18270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GH913_RS18275	COG3291	Pkd domain containing protein
GH913_RS18280	COG0405	Gamma-glutamyltransferase
GH913_RS18285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GH913_RS18295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GH913_RS18300	COG0742	ribosomal rna small subunit methyltransferase
GH913_RS18305	COG0326	Molecular chaperone. Has ATPase activity
GH913_RS18340	COG4206	TonB-dependent receptor
GH913_RS18405	COG0531	amino acid
GH913_RS18420	COG0006	proline dipeptidase activity
GH913_RS18430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH913_RS18445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH913_RS18450	COG3938	Belongs to the proline racemase family
GH913_RS18460	COG0552	protein localization to endoplasmic reticulum
GH913_RS18465	COG1194	a g-specific adenine glycosylase
GH913_RS18470	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GH913_RS18475	COG4191	Histidine kinase
GH913_RS18475	COG0784	Response regulator, receiver
GH913_RS18490	COG0322	excinuclease ABC activity
GH913_RS18505	COG3040	lipid binding
GH913_RS18520	COG1960	acyl-CoA dehydrogenase activity
GH913_RS18530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GH913_RS18550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH913_RS18555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH913_RS18560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH913_RS18585	COG0438	transferase activity, transferring glycosyl groups
GH913_RS18595	COG0438	transferase activity, transferring glycosyl groups
GH913_RS18600	COG0438	transferase activity, transferring glycosyl groups
GH913_RS18650	COG0072	phenylalanine-tRNA ligase activity
GH913_RS18650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH913_RS18655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GH913_RS18670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GH913_RS18675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GH913_RS18700	COG1082	Xylose isomerase domain protein TIM barrel
GH913_RS18765	COG3702	type iv secretory pathway
GH913_RS18785	COG2948	multi-organism process
GH913_RS18805	COG3505	Type IV secretory pathway VirD4
GH913_RS18820	COG0556	nucleotide-excision repair
GH913_RS18865	COG1611	Belongs to the LOG family
GH913_RS18875	COG2095	MarC family integral membrane protein
GH913_RS18885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GH913_RS18920	COG1185	polyribonucleotide nucleotidyltransferase activity
GH913_RS18925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GH913_RS18930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GH913_RS18935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GH913_RS18940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GH913_RS18945	COG0195	Participates in both transcription termination and antitermination
GH913_RS18950	COG0779	Required for maturation of 30S ribosomal subunits
GH913_RS18960	COG1007	ATP synthesis coupled electron transport
GH913_RS18985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH913_RS18990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GH913_RS19000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GH913_RS19005	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GH913_RS19010	COG0649	NAD binding
GH913_RS19015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH913_RS19020	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH913_RS19025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH913_RS19040	COG0149	triose-phosphate isomerase activity
GH913_RS19045	COG0300	oxidoreductase activity
GH913_RS19075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GH913_RS19080	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GH913_RS19085	COG0159	tryptophan synthase activity
GH913_RS19095	COG0133	tryptophan synthase activity
GH913_RS19105	COG0135	phosphoribosylanthranilate isomerase activity
GH913_RS19110	COG0101	tRNA pseudouridine synthase activity
GH913_RS19130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GH913_RS19135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GH913_RS19140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GH913_RS19145	COG2890	protein-(glutamine-N5) methyltransferase activity
GH913_RS19155	COG0688	phosphatidylethanolamine metabolic process
GH913_RS19175	COG0494	nUDIX hydrolase
GH913_RS19195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GH913_RS19200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GH913_RS19210	COG2336	PFAM SpoVT AbrB
GH913_RS19220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GH913_RS19225	COG1404	Belongs to the peptidase S8 family
GH913_RS19265	COG0717	Belongs to the dCTP deaminase family
GH913_RS19270	COG0489	protein tyrosine kinase activity
GH913_RS19290	COG3590	peptidase
GH913_RS19295	COG3590	peptidase
GH913_RS19315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GH913_RS19320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH913_RS19325	COG2311	Membrane
GH913_RS19330	COG1047	Peptidyl-prolyl cis-trans
GH913_RS19335	COG0791	NLP P60 protein
GH913_RS19340	COG0791	NLP P60 protein
GH913_RS19350	COG4106	trans-aconitate 2-methyltransferase activity
GH913_RS19355	COG1301	dicarboxylic acid transport
GH913_RS19360	COG1785	Belongs to the alkaline phosphatase family
GH913_RS19365	COG0037	tRNA processing
GH913_RS19370	COG1722	exodeoxyribonuclease VII activity
GH913_RS19375	COG0142	geranyltranstransferase activity
GH913_RS19385	COG4104	PAAR repeat-containing protein
GH913_RS19395	COG0312	modulator of DNA gyrase
GH913_RS19400	COG3028	Belongs to the UPF0307 family
GH913_RS19405	COG0312	modulator of DNA gyrase
GH913_RS19415	COG3164	Protein of unknown function
GH913_RS19425	COG0424	maF-like protein
GH913_RS19430	COG2968	Membrane
GH913_RS19445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GH913_RS19460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GH913_RS19475	COG0495	leucyl-tRNA aminoacylation
GH913_RS19485	COG3118	belongs to the thioredoxin family
GH913_RS19510	COG2155	Conserved Protein
GH913_RS19560	COG1132	(ABC) transporter
GH913_RS19590	COG1538	Outer membrane efflux protein
GH913_RS19595	COG0745	RESPONSE REGULATOR receiver
GH913_RS19605	COG0475	glutathione-regulated potassium exporter activity
GH913_RS19615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GH913_RS19635	COG1187	pseudouridine synthase activity
GH913_RS19640	COG5001	Diguanylate cyclase
GH913_RS19640	COG5002	protein histidine kinase activity
GH913_RS19765	COG2814	Major facilitator Superfamily
GH913_RS19770	COG0583	DNA-binding transcription factor activity
GH913_RS19780	COG2207	Transcriptional regulator
GH913_RS19795	COG0667	Aldo Keto reductase
GH913_RS19800	COG1309	transcriptional regulator
GH913_RS19810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH913_RS19825	COG0735	belongs to the Fur family
GH913_RS19830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GH913_RS19855	COG4452	Inner membrane protein CreD
GH913_RS19875	COG2205	protein histidine kinase activity
GH913_RS19880	COG0745	RESPONSE REGULATOR receiver
GH913_RS19885	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GH913_RS19895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GH913_RS19930	COG2198	Histidine kinase
GH913_RS19930	COG0643	Histidine kinase
GH913_RS19935	COG0840	transmembrane signaling receptor activity
GH913_RS19940	COG0835	chemotaxis
GH913_RS19945	COG2200	EAL domain
GH913_RS19945	COG2202	Pas domain
GH913_RS19945	COG2199	diguanylate cyclase activity
GH913_RS19950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GH913_RS19955	COG2201	protein-glutamate methylesterase activity
GH913_RS19960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_RS19965	COG3590	peptidase
GH913_RS19975	COG0588	phosphoglycerate mutase activity
GH913_RS19980	COG1515	deoxyribonuclease V activity
GH913_RS19990	COG1741	Belongs to the pirin family
GH913_RS20005	COG1741	Belongs to the pirin family
GH913_RS20010	COG1966	Carbon starvation protein
GH913_RS20015	COG2879	small protein
GH913_RS20050	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GH913_RS20055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GH913_RS20060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GH913_RS20065	COG2080	2 iron, 2 sulfur cluster binding
GH913_RS20070	COG3321	synthase
GH913_RS20070	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS20070	COG0604	alcohol dehydrogenase
GH913_RS20080	COG0629	single-stranded DNA binding
GH913_RS20085	COG0142	geranyltranstransferase activity
GH913_RS20100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GH913_RS20115	COG0527	aspartate kinase activity
GH913_RS20120	COG0384	phenazine biosynthesis protein PhzF
GH913_RS20125	COG0384	phenazine biosynthesis protein PhzF
GH913_RS20135	COG1764	response to oxidative stress
GH913_RS20140	COG0540	Belongs to the ATCase OTCase family
GH913_RS20145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GH913_RS20150	COG1678	Uncharacterized ACR, COG1678
GH913_RS20155	COG0519	Catalyzes the synthesis of GMP from XMP
GH913_RS20180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GH913_RS20195	COG0739	heme binding
GH913_RS20215	COG0693	protein deglycase activity
GH913_RS20225	COG1959	2 iron, 2 sulfur cluster binding
GH913_RS20230	COG0719	Fe-S assembly protein
GH913_RS20235	COG0396	ATPase activity
GH913_RS20240	COG0719	Fe-S assembly protein
GH913_RS20245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GH913_RS20255	COG2146	nitrite reductase [NAD(P)H] activity
GH913_RS20260	COG4774	siderophore transport
GH913_RS20265	COG3128	pkhd-type hydroxylase
GH913_RS20290	COG1477	protein flavinylation
GH913_RS20295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GH913_RS20310	COG1555	photosystem II stabilization
GH913_RS20325	COG3178	'Phosphotransferase
GH913_RS20330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GH913_RS20340	COG0628	permease
GH913_RS20350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GH913_RS20365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GH913_RS20385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GH913_RS20390	COG0271	Belongs to the BolA IbaG family
GH913_RS20400	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GH913_RS20410	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GH913_RS20415	COG1137	ATPase activity
GH913_RS20430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH913_RS20435	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GH913_RS20440	COG1660	Displays ATPase and GTPase activities
GH913_RS20450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH913_RS20455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GH913_RS20460	COG2239	Acts as a magnesium transporter
GH913_RS20475	COG1294	oxidase, subunit
GH913_RS20480	COG1271	oxidase subunit
GH913_RS20490	COG1113	amino acid transport
GH913_RS20520	COG2197	response regulator
GH913_RS20525	COG0531	amino acid
GH913_RS20615	COG0754	glutathionylspermidine amidase activity
GH913_RS20640	COG1842	Phage shock protein A
GH913_RS20650	COG0259	pyridoxamine-phosphate oxidase activity
GH913_RS20655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GH913_RS20660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GH913_RS20670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GH913_RS20695	COG0784	Response regulator, receiver
GH913_RS20695	COG2198	Histidine kinase
GH913_RS20695	COG2205	protein histidine kinase activity
GH913_RS20700	COG2353	YceI-like domain
GH913_RS20720	COG1760	l-serine dehydratase
GH913_RS20730	COG0460	homoserine dehydrogenase
GH913_RS20730	COG0527	aspartate kinase activity
GH913_RS20735	COG0626	cystathionine gamma-synthase activity
GH913_RS20740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GH913_RS20745	COG0739	heme binding
GH913_RS20750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GH913_RS20755	COG1272	protein, Hemolysin III
GH913_RS20760	COG2982	Protein involved in outer membrane biogenesis
GH913_RS20765	COG0516	GMP reductase activity
GH913_RS20765	COG0517	IMP dehydrogenase activity
GH913_RS20770	COG0463	Glycosyl transferase, family 2
GH913_RS20775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GH913_RS20780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GH913_RS20790	COG4771	TonB-dependent receptor
GH913_RS20820	COG1309	transcriptional regulator
GH913_RS20830	COG1960	acyl-CoA dehydrogenase activity
GH913_RS20860	COG0509	glycine decarboxylation via glycine cleavage system
GH913_RS20865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GH913_RS20880	COG1742	UPF0060 membrane protein
GH913_RS20885	COG3956	TIGRFAM MazG family protein
GH913_RS20895	COG0494	nUDIX hydrolase
GH913_RS20905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GH913_RS20910	COG0837	glucose binding
GH913_RS20925	COG3858	chitin binding
GH913_RS20925	COG1388	LysM domain
GH913_RS20940	COG1472	Belongs to the glycosyl hydrolase 3 family
GH913_RS20995	COG3537	Alpha-1,2-mannosidase
GH913_RS21030	COG3142	Participates in the control of copper homeostasis
GH913_RS21035	COG1446	asparaginase
GH913_RS21055	COG0643	Histidine kinase
GH913_RS21055	COG0784	Response regulator, receiver
GH913_RS21055	COG2198	Histidine kinase
GH913_RS21060	COG0840	transmembrane signaling receptor activity
GH913_RS21065	COG0835	chemotaxis
GH913_RS21080	COG0189	ligase activity
GH913_RS21090	COG1397	ADP-ribosylglycohydrolase
GH913_RS21100	COG1199	ATP-dependent helicase activity
GH913_RS21110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GH913_RS21115	COG1215	transferase activity, transferring glycosyl groups
GH913_RS21125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GH913_RS21135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GH913_RS21140	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GH913_RS21145	COG0535	radical SAM domain protein
GH913_RS21150	COG0535	radical SAM domain protein
GH913_RS21165	COG0837	glucose binding
GH913_RS21180	COG1643	Atp-dependent helicase
GH913_RS21185	COG0783	Belongs to the Dps family
GH913_RS21190	COG0514	ATP-dependent DNA helicase (RecQ)
GH913_RS21225	COG0840	transmembrane signaling receptor activity
GH913_RS21245	COG3920	Histidine kinase
GH913_RS21250	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GH913_RS21260	COG0602	queuosine metabolic process
GH913_RS21270	COG2885	chlorophyll binding
GH913_RS21275	COG0823	Involved in the tonB-independent uptake of proteins
GH913_RS21285	COG0848	biopolymer transport protein
GH913_RS21295	COG0824	Thioesterase
GH913_RS21300	COG2255	four-way junction helicase activity
GH913_RS21310	COG3158	transport of potassium into the cell
GH913_RS21315	COG0632	four-way junction helicase activity
GH913_RS21320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GH913_RS21325	COG0217	transcriptional regulatory protein
GH913_RS21340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GH913_RS21355	COG0477	Major facilitator Superfamily
GH913_RS21395	COG0488	(ABC) transporter
GH913_RS21425	COG4651	solute:proton antiporter activity
GH913_RS21425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GH913_RS21450	COG4772	TonB-dependent receptor
GH913_RS21460	COG4264	IucA IucC family
GH913_RS21475	COG0019	diaminopimelate decarboxylase activity
GH913_RS21495	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GH913_RS21505	COG1492	cobalamin metabolic process
GH913_RS21515	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GH913_RS21535	COG4206	TonB-dependent receptor
GH913_RS21540	COG0542	response to heat
GH913_RS21545	COG1116	anion transmembrane transporter activity
GH913_RS21550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH913_RS21555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GH913_RS21560	COG0667	Aldo Keto reductase
GH913_RS21570	COG4771	TonB-dependent receptor
GH913_RS21575	COG2827	Endonuclease containing a URI domain
GH913_RS21615	COG1877	trehalose-phosphatase activity
GH913_RS21620	COG3387	PFAM Glycoside hydrolase 15-related
GH913_RS21635	COG0840	transmembrane signaling receptor activity
GH913_RS21640	COG3011	Protein conserved in bacteria
GH913_RS21655	COG0564	pseudouridine synthase activity
GH913_RS21660	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH913_RS21670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH913_RS21670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GH913_RS21685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GH913_RS21690	COG0045	succinate-CoA ligase (ADP-forming) activity
GH913_RS21715	COG4969	Belongs to the N-Me-Phe pilin family
GH913_RS21730	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GH913_RS21735	COG0237	dephospho-CoA kinase activity
GH913_RS21770	COG5002	protein histidine kinase activity
GH913_RS21775	COG0745	RESPONSE REGULATOR receiver
GH913_RS21785	COG0189	ligase activity
GH913_RS21900	COG1752	Esterase of the alpha-beta hydrolase superfamily
GH913_RS21925	COG2022	thiamine diphosphate biosynthetic process
GH913_RS21930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GH913_RS21935	COG0471	metal ion transport
GH913_RS21935	COG3273	potassium ion transport
GH913_RS21955	COG1970	mechanosensitive ion channel activity
GH913_RS21965	COG1609	Transcriptional regulator
GH913_RS21975	COG3250	beta-galactosidase activity
GH913_RS21980	COG4948	Mandelate Racemase Muconate Lactonizing
GH913_RS21995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GH913_RS22005	COG0308	aminopeptidase N
GH913_RS22030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH913_RS22040	COG2895	sulfate adenylyltransferase (ATP) activity
GH913_RS22040	COG0529	Catalyzes the synthesis of activated sulfate
GH913_RS22045	COG0175	sulfate reduction
GH913_RS22050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GH913_RS22055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GH913_RS22060	COG0175	sulfate reduction
GH913_RS22080	COG0784	Response regulator, receiver
GH913_RS22080	COG2198	Histidine kinase
GH913_RS22080	COG2205	protein histidine kinase activity
GH913_RS22095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GH913_RS22095	COG1648	precorrin-2 dehydrogenase activity
GH913_RS22110	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GH913_RS22115	COG3588	fructose-bisphosphate aldolase
GH913_RS22120	COG0469	pyruvate kinase activity
GH913_RS22130	COG0126	phosphoglycerate kinase activity
GH913_RS22150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GH913_RS22160	COG3047	cAMP biosynthetic process
GH913_RS22165	COG3047	cAMP biosynthetic process
GH913_RS22175	COG3453	Protein conserved in bacteria
GH913_RS22175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH913_RS22180	COG0725	ABC transporter, periplasmic molybdate-binding protein
GH913_RS22185	COG4149	molybdate abc transporter
GH913_RS22190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GH913_RS22230	COG0739	heme binding
GH913_RS22240	COG4773	Receptor
GH913_RS22250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GH913_RS22255	COG1301	dicarboxylic acid transport
GH913_RS22265	COG2304	oxidoreductase activity
GH913_RS22285	COG0714	Associated with various cellular activities
GH913_RS22315	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GH913_RS22340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GH913_RS22350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GH913_RS22360	COG0194	GDP metabolic process
GH913_RS22365	COG1561	YicC-like family, N-terminal region
GH913_RS22370	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GH913_RS22380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GH913_RS22385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GH913_RS22400	COG0006	proline dipeptidase activity
GH913_RS22410	COG0006	proline dipeptidase activity
GH913_RS22415	COG3079	Belongs to the UPF0149 family
GH913_RS22435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GH913_RS22445	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GH913_RS22455	COG2912	Transglutaminase-like superfamily
GH913_RS22460	COG1773	rubredoxin
GH913_RS22465	COG0352	thiamine-phosphate diphosphorylase activity
GH913_RS22475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GH913_RS22490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GH913_RS22520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GH913_RS22525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH913_RS22530	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_RS22540	COG0671	phosphoesterase, PA-phosphatase related
GH913_RS22545	COG3781	membrane
GH913_RS22555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GH913_RS22560	COG0563	adenylate kinase activity
GH913_RS22580	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GH913_RS22590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GH913_RS22610	COG3710	Transcriptional regulator
GH913_RS22615	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GH913_RS22625	COG0840	transmembrane signaling receptor activity
GH913_RS22630	COG0405	Gamma-glutamyltransferase
GH913_RS22635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GH913_RS22725	COG1192	Involved in chromosome partitioning
GH913_RS22750	COG4644	lycopene metabolic process
GH913_RS22785	COG4456	Virulence-associated protein
GH913_RS22805	COG2951	lytic endotransglycosylase activity
GH913_RS22840	COG1192	Involved in chromosome partitioning
GH913_RS22950	COG1192	Involved in chromosome partitioning
GH913_RS23010	COG3012	SEC-C Motif Domain Protein
GH913_RS23010	COG3318	Belongs to the UPF0149 family
GH913_RS23030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs