locus-tag	class	description
CAI14_RS00005	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAI14_RS00010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CAI14_RS00015	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CAI14_RS00020	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CAI14_RS00025	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CAI14_RS00040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CAI14_RS00045	COG4191	Histidine kinase
CAI14_RS00060	COG0577	efflux transmembrane transporter activity
CAI14_RS00065	COG0577	efflux transmembrane transporter activity
CAI14_RS00070	COG4591	ABC-type transport system involved in lipoprotein release permease component
CAI14_RS00070	COG1136	(ABC) transporter
CAI14_RS00075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI14_RS00080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAI14_RS00120	COG2132	Multicopper oxidase
CAI14_RS00135	COG0339	signal peptide processing
CAI14_RS00150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAI14_RS00155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CAI14_RS00170	COG2819	hydrolase of the alpha beta superfamily
CAI14_RS00180	COG1956	GAF domain-containing protein
CAI14_RS00185	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CAI14_RS00195	COG0720	synthase
CAI14_RS00200	COG4206	TonB-dependent receptor
CAI14_RS00210	COG0513	Belongs to the DEAD box helicase family
CAI14_RS00220	COG0625	glutathione transferase activity
CAI14_RS00250	COG0626	cystathionine gamma-synthase activity
CAI14_RS00270	COG0438	transferase activity, transferring glycosyl groups
CAI14_RS00270	COG1216	Glycosyl transferase, family 2
CAI14_RS00305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAI14_RS00320	COG0277	FAD linked oxidase domain protein
CAI14_RS00325	COG0546	phosphoglycolate phosphatase activity
CAI14_RS00325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CAI14_RS00340	COG2086	electron transfer activity
CAI14_RS00370	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CAI14_RS00370	COG0662	Cupin 2, conserved barrel domain protein
CAI14_RS00375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAI14_RS00410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAI14_RS00410	COG3218	ABC-type transport auxiliary lipoprotein component
CAI14_RS00415	COG1127	ABC transporter
CAI14_RS00420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAI14_RS00435	COG0442	prolyl-tRNA aminoacylation
CAI14_RS00445	COG1183	phosphatidylcholine synthase activity
CAI14_RS00470	COG0741	lytic transglycosylase activity
CAI14_RS00490	COG0525	valine-tRNA ligase activity
CAI14_RS00505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CAI14_RS00515	COG0795	lipopolysaccharide-transporting ATPase activity
CAI14_RS00530	COG4974	Belongs to the 'phage' integrase family
CAI14_RS00535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAI14_RS00540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAI14_RS00540	COG0047	phosphoribosylformylglycinamidine synthase activity
CAI14_RS00550	COG1404	Belongs to the peptidase S8 family
CAI14_RS00555	COG5295	Hep Hag repeat protein
CAI14_RS00560	COG1404	Belongs to the peptidase S8 family
CAI14_RS00565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CAI14_RS00570	COG1459	type II secretion system
CAI14_RS00575	COG2165	general secretion pathway protein
CAI14_RS00580	COG4970	Tfp pilus assembly protein FimT
CAI14_RS00585	COG2165	general secretion pathway protein
CAI14_RS00590	COG4795	General secretion pathway protein
CAI14_RS00595	COG3156	type II secretion system protein K
CAI14_RS00600	COG3166	PFAM Fimbrial assembly family protein
CAI14_RS00615	COG1450	Type ii and iii secretion system protein
CAI14_RS00630	COG2188	Transcriptional regulator
CAI14_RS00685	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CAI14_RS00700	COG1215	transferase activity, transferring glycosyl groups
CAI14_RS00705	COG1215	transferase activity, transferring glycosyl groups
CAI14_RS00710	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CAI14_RS00715	COG0457	Tetratricopeptide repeat
CAI14_RS00735	COG0242	peptide deformylase activity
CAI14_RS00740	COG1307	EDD domain protein, DegV family
CAI14_RS00770	COG0402	S-adenosylhomocysteine deaminase activity
CAI14_RS00775	COG3964	amidohydrolase
CAI14_RS00790	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CAI14_RS00795	COG0726	polysaccharide deacetylase
CAI14_RS00815	COG0436	Aminotransferase
CAI14_RS00835	COG0237	dephospho-CoA kinase activity
CAI14_RS00840	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CAI14_RS00845	COG1459	type II secretion system
CAI14_RS00880	COG0045	succinate-CoA ligase (ADP-forming) activity
CAI14_RS00885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CAI14_RS00895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAI14_RS00895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CAI14_RS00905	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAI14_RS00910	COG0564	pseudouridine synthase activity
CAI14_RS00925	COG3011	Protein conserved in bacteria
CAI14_RS00930	COG0840	transmembrane signaling receptor activity
CAI14_RS00945	COG3387	PFAM Glycoside hydrolase 15-related
CAI14_RS00950	COG1877	trehalose-phosphatase activity
CAI14_RS00990	COG2827	Endonuclease containing a URI domain
CAI14_RS01000	COG4771	TonB-dependent receptor
CAI14_RS01005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAI14_RS01010	COG0667	Aldo Keto reductase
CAI14_RS01015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAI14_RS01020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAI14_RS01025	COG1116	anion transmembrane transporter activity
CAI14_RS01030	COG0542	response to heat
CAI14_RS01035	COG4206	TonB-dependent receptor
CAI14_RS01065	COG1492	cobalamin metabolic process
CAI14_RS01075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CAI14_RS01105	COG0019	diaminopimelate decarboxylase activity
CAI14_RS01120	COG4264	IucA IucC family
CAI14_RS01130	COG4772	TonB-dependent receptor
CAI14_RS01155	COG4651	solute:proton antiporter activity
CAI14_RS01155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAI14_RS01185	COG0488	(ABC) transporter
CAI14_RS01225	COG0477	Major facilitator Superfamily
CAI14_RS01240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CAI14_RS01255	COG0217	transcriptional regulatory protein
CAI14_RS01260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CAI14_RS01265	COG0632	four-way junction helicase activity
CAI14_RS01270	COG3158	transport of potassium into the cell
CAI14_RS01280	COG2255	four-way junction helicase activity
CAI14_RS01285	COG0824	Thioesterase
CAI14_RS01295	COG0848	biopolymer transport protein
CAI14_RS01305	COG0823	Involved in the tonB-independent uptake of proteins
CAI14_RS01310	COG2885	chlorophyll binding
CAI14_RS01320	COG0602	queuosine metabolic process
CAI14_RS01330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CAI14_RS01335	COG3920	Histidine kinase
CAI14_RS01355	COG0840	transmembrane signaling receptor activity
CAI14_RS01385	COG0514	ATP-dependent DNA helicase (RecQ)
CAI14_RS01390	COG0783	Belongs to the Dps family
CAI14_RS01395	COG1643	Atp-dependent helicase
CAI14_RS01420	COG0535	radical SAM domain protein
CAI14_RS01425	COG0535	radical SAM domain protein
CAI14_RS01430	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CAI14_RS01435	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CAI14_RS01445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAI14_RS01455	COG1215	transferase activity, transferring glycosyl groups
CAI14_RS01460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAI14_RS01470	COG1199	ATP-dependent helicase activity
CAI14_RS01480	COG1397	ADP-ribosylglycohydrolase
CAI14_RS01490	COG0189	ligase activity
CAI14_RS01505	COG0835	chemotaxis
CAI14_RS01510	COG0840	transmembrane signaling receptor activity
CAI14_RS01515	COG2198	Histidine kinase
CAI14_RS01515	COG0643	Histidine kinase
CAI14_RS01515	COG0784	Response regulator, receiver
CAI14_RS01535	COG1446	asparaginase
CAI14_RS01540	COG3142	Participates in the control of copper homeostasis
CAI14_RS01575	COG3537	Alpha-1,2-mannosidase
CAI14_RS01610	COG1472	Belongs to the glycosyl hydrolase 3 family
CAI14_RS01620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CAI14_RS01625	COG3858	chitin binding
CAI14_RS01625	COG1388	LysM domain
CAI14_RS01640	COG0837	glucose binding
CAI14_RS01645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CAI14_RS01655	COG0494	nUDIX hydrolase
CAI14_RS01665	COG3956	TIGRFAM MazG family protein
CAI14_RS01670	COG1742	UPF0060 membrane protein
CAI14_RS01685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAI14_RS01690	COG0509	glycine decarboxylation via glycine cleavage system
CAI14_RS01720	COG1960	acyl-CoA dehydrogenase activity
CAI14_RS01730	COG1309	transcriptional regulator
CAI14_RS01745	COG4771	TonB-dependent receptor
CAI14_RS01755	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CAI14_RS01760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAI14_RS01765	COG0463	Glycosyl transferase, family 2
CAI14_RS01770	COG0517	IMP dehydrogenase activity
CAI14_RS01770	COG0516	GMP reductase activity
CAI14_RS01775	COG2982	Protein involved in outer membrane biogenesis
CAI14_RS01780	COG1272	protein, Hemolysin III
CAI14_RS01785	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CAI14_RS01790	COG0739	heme binding
CAI14_RS01795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAI14_RS01800	COG0626	cystathionine gamma-synthase activity
CAI14_RS01805	COG0460	homoserine dehydrogenase
CAI14_RS01805	COG0527	aspartate kinase activity
CAI14_RS01815	COG1760	l-serine dehydratase
CAI14_RS01835	COG2353	YceI-like domain
CAI14_RS01840	COG2198	Histidine kinase
CAI14_RS01840	COG0784	Response regulator, receiver
CAI14_RS01840	COG2205	protein histidine kinase activity
CAI14_RS01860	COG0477	Major facilitator Superfamily
CAI14_RS01865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CAI14_RS01875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CAI14_RS01880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CAI14_RS01885	COG0259	pyridoxamine-phosphate oxidase activity
CAI14_RS01895	COG1842	Phage shock protein A
CAI14_RS01920	COG0754	glutathionylspermidine amidase activity
CAI14_RS01930	COG2814	Major facilitator Superfamily
CAI14_RS01985	COG1234	tRNA 3'-trailer cleavage
CAI14_RS02005	COG0531	amino acid
CAI14_RS02010	COG2197	response regulator
CAI14_RS02030	COG1113	amino acid transport
CAI14_RS02050	COG1271	oxidase subunit
CAI14_RS02055	COG1294	oxidase, subunit
CAI14_RS02070	COG2239	Acts as a magnesium transporter
CAI14_RS02075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAI14_RS02080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAI14_RS02090	COG1660	Displays ATPase and GTPase activities
CAI14_RS02095	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CAI14_RS02100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAI14_RS02115	COG1137	ATPase activity
CAI14_RS02120	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CAI14_RS02130	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CAI14_RS02140	COG0271	Belongs to the BolA IbaG family
CAI14_RS02145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAI14_RS02165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CAI14_RS02175	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CAI14_RS02185	COG0628	permease
CAI14_RS02195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CAI14_RS02200	COG3178	'Phosphotransferase
CAI14_RS02215	COG1555	photosystem II stabilization
CAI14_RS02230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CAI14_RS02235	COG1477	protein flavinylation
CAI14_RS02260	COG3128	pkhd-type hydroxylase
CAI14_RS02265	COG4774	siderophore transport
CAI14_RS02270	COG2146	nitrite reductase [NAD(P)H] activity
CAI14_RS02280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAI14_RS02285	COG0719	Fe-S assembly protein
CAI14_RS02290	COG0396	ATPase activity
CAI14_RS02295	COG0719	Fe-S assembly protein
CAI14_RS02300	COG1959	2 iron, 2 sulfur cluster binding
CAI14_RS02310	COG0693	protein deglycase activity
CAI14_RS02330	COG0739	heme binding
CAI14_RS02345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CAI14_RS02360	COG5297	Belongs to the glycosyl hydrolase family 6
CAI14_RS02375	COG0519	Catalyzes the synthesis of GMP from XMP
CAI14_RS02380	COG1678	Uncharacterized ACR, COG1678
CAI14_RS02385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CAI14_RS02390	COG0540	Belongs to the ATCase OTCase family
CAI14_RS02395	COG1764	response to oxidative stress
CAI14_RS02410	COG0384	phenazine biosynthesis protein PhzF
CAI14_RS02415	COG0527	aspartate kinase activity
CAI14_RS02430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CAI14_RS02445	COG0142	geranyltranstransferase activity
CAI14_RS02450	COG0629	single-stranded DNA binding
CAI14_RS02455	COG5001	Diguanylate cyclase
CAI14_RS02455	COG3706	GGDEF domain
CAI14_RS02455	COG2203	Gaf domain
CAI14_RS02455	COG4251	negative regulation of phosphorylation
CAI14_RS02460	COG3321	synthase
CAI14_RS02460	COG0604	alcohol dehydrogenase
CAI14_RS02460	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS02465	COG2080	2 iron, 2 sulfur cluster binding
CAI14_RS02470	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CAI14_RS02475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAI14_RS02480	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CAI14_RS02515	COG2879	small protein
CAI14_RS02520	COG1966	Carbon starvation protein
CAI14_RS02525	COG1741	Belongs to the pirin family
CAI14_RS02550	COG1515	deoxyribonuclease V activity
CAI14_RS02555	COG0588	phosphoglycerate mutase activity
CAI14_RS02590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CAI14_RS02595	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CAI14_RS02610	COG3829	transcription factor binding
CAI14_RS02620	COG1116	anion transmembrane transporter activity
CAI14_RS02625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAI14_RS02635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAI14_RS02640	COG0431	NADPH-dependent FMN reductase
CAI14_RS02665	COG0747	negative chemotaxis
CAI14_RS02675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAI14_RS02685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CAI14_RS02690	COG2967	ApaG domain
CAI14_RS02695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CAI14_RS02700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CAI14_RS02705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAI14_RS02710	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CAI14_RS02715	COG0123	including yeast histone deacetylase and acetoin utilization protein
CAI14_RS02720	COG2096	Adenosyltransferase
CAI14_RS02730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAI14_RS02735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAI14_RS02765	COG3384	dioxygenase
CAI14_RS02770	COG0583	DNA-binding transcription factor activity
CAI14_RS02775	COG0318	PFAM AMP-dependent synthetase and ligase
CAI14_RS02785	COG1024	Enoyl-CoA hydratase
CAI14_RS02805	COG3386	PFAM SMP-30 Gluconolaconase
CAI14_RS02820	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CAI14_RS02845	COG0697	spore germination
CAI14_RS02850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAI14_RS02885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAI14_RS02895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CAI14_RS02900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAI14_RS02905	COG0583	DNA-binding transcription factor activity
CAI14_RS02910	COG3634	alkyl hydroperoxide reductase activity
CAI14_RS02920	COG2890	protein-(glutamine-N5) methyltransferase activity
CAI14_RS02940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAI14_RS02940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAI14_RS02970	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CAI14_RS02990	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CAI14_RS03010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAI14_RS03015	COG1404	Belongs to the peptidase S8 family
CAI14_RS03020	COG1404	Belongs to the peptidase S8 family
CAI14_RS03025	COG1404	Belongs to the peptidase S8 family
CAI14_RS03030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CAI14_RS03055	COG1295	ribonuclease BN
CAI14_RS03065	COG1254	Belongs to the acylphosphatase family
CAI14_RS03095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CAI14_RS03100	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CAI14_RS03110	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CAI14_RS03115	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CAI14_RS03125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CAI14_RS03130	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CAI14_RS03135	COG0193	aminoacyl-tRNA hydrolase activity
CAI14_RS03140	COG0012	GTP binding
CAI14_RS03160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAI14_RS03175	COG0250	Participates in transcription elongation, termination and antitermination
CAI14_RS03180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CAI14_RS03185	COG0081	regulation of translation
CAI14_RS03190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CAI14_RS03195	COG0222	ribosome binding
CAI14_RS03200	COG0085	RNA polymerase activity
CAI14_RS03205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CAI14_RS03210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CAI14_RS03215	COG0049	tRNA binding
CAI14_RS03220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAI14_RS03225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAI14_RS03230	COG0051	transcription antitermination factor activity, RNA binding
CAI14_RS03235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CAI14_RS03240	COG0088	Forms part of the polypeptide exit tunnel
CAI14_RS03245	COG0089	rRNA binding
CAI14_RS03250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CAI14_RS03255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CAI14_RS03265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CAI14_RS03270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CAI14_RS03275	COG0255	Belongs to the universal ribosomal protein uL29 family
CAI14_RS03280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CAI14_RS03290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CAI14_RS03295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CAI14_RS03305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CAI14_RS03310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CAI14_RS03315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CAI14_RS03325	COG1841	ribosomal large subunit assembly
CAI14_RS03330	COG0200	Binds to the 23S rRNA
CAI14_RS03335	COG0201	protein transport
CAI14_RS03360	COG0203	ribosomal protein L17
CAI14_RS03365	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CAI14_RS03380	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CAI14_RS03390	COG0154	amidase activity
CAI14_RS03400	COG1217	gtp-binding protein TYPA
CAI14_RS03405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CAI14_RS03410	COG0039	L-malate dehydrogenase activity
CAI14_RS03420	COG0625	glutathione transferase activity
CAI14_RS03430	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAI14_RS03430	COG1902	pentaerythritol trinitrate reductase activity
CAI14_RS03460	COG0156	8-amino-7-oxononanoate synthase activity
CAI14_RS03465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CAI14_RS03470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CAI14_RS03475	COG4208	sulfate ABC transporter
CAI14_RS03480	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CAI14_RS03490	COG1063	alcohol dehydrogenase
CAI14_RS03525	COG0406	alpha-ribazole phosphatase activity
CAI14_RS03540	COG0285	dihydrofolate synthase activity
CAI14_RS03560	COG2833	Protein of unknown function (DUF455)
CAI14_RS03575	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAI14_RS03580	COG0671	phosphoesterase, PA-phosphatase related
CAI14_RS03585	COG0438	transferase activity, transferring glycosyl groups
CAI14_RS03595	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CAI14_RS03610	COG4783	chaperone-mediated protein folding
CAI14_RS03625	COG0473	3-isopropylmalate dehydrogenase activity
CAI14_RS03655	COG3852	Histidine kinase
CAI14_RS03665	COG0544	peptidyl-prolyl cis-trans isomerase activity
CAI14_RS03675	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CAI14_RS03700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAI14_RS03710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAI14_RS03720	COG0328	RNA-DNA hybrid ribonuclease activity
CAI14_RS03725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAI14_RS03730	COG0631	protein serine/threonine phosphatase activity
CAI14_RS03745	COG0859	PFAM glycosyl transferase family 9
CAI14_RS03750	COG3642	lipopolysaccharide core region biosynthetic process
CAI14_RS03755	COG1234	tRNA 3'-trailer cleavage
CAI14_RS03760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CAI14_RS03765	COG0315	cyclic pyranopterin monophosphate synthase activity
CAI14_RS03770	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CAI14_RS03775	COG0314	molybdopterin synthase activity
CAI14_RS03795	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CAI14_RS03800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CAI14_RS03805	COG0537	adenosine 5'-monophosphoramidase activity
CAI14_RS03825	COG0714	Associated with various cellular activities
CAI14_RS03855	COG0424	maF-like protein
CAI14_RS03860	COG1399	metal-binding, possibly nucleic acid-binding protein
CAI14_RS03865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CAI14_RS03870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAI14_RS03885	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS03900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CAI14_RS03905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CAI14_RS03930	COG3829	transcription factor binding
CAI14_RS03950	COG3609	addiction module antidote protein, CC2985 family
CAI14_RS03975	COG2373	Large extracellular alpha-helical protein
CAI14_RS03990	COG4953	penicillin-binding protein 1C
CAI14_RS04000	COG0678	peroxiredoxin activity
CAI14_RS04020	COG0330	HflC and HflK could
CAI14_RS04025	COG0330	HflC and HflK could
CAI14_RS04035	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CAI14_RS04040	COG0308	aminopeptidase N
CAI14_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS04050	COG1309	transcriptional regulator
CAI14_RS04080	COG0732	type I restriction modification DNA specificity domain
CAI14_RS04105	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CAI14_RS04135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CAI14_RS04145	COG3387	PFAM Glycoside hydrolase 15-related
CAI14_RS04150	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS04155	COG3537	Alpha-1,2-mannosidase
CAI14_RS04160	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS04170	COG0492	ferredoxin-NADP+ reductase activity
CAI14_RS04230	COG2207	Transcriptional regulator
CAI14_RS04230	COG1917	Cupin 2, conserved barrel domain protein
CAI14_RS04250	COG0753	catalase activity
CAI14_RS04255	COG0656	L-ascorbic acid biosynthetic process
CAI14_RS04265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAI14_RS04265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAI14_RS04270	COG2814	Major facilitator Superfamily
CAI14_RS04285	COG2194	sulfuric ester hydrolase activity
CAI14_RS04300	COG0745	RESPONSE REGULATOR receiver
CAI14_RS04305	COG0642	Histidine kinase
CAI14_RS04315	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CAI14_RS04320	COG2894	cell division
CAI14_RS04325	COG0850	regulation of cytokinetic process
CAI14_RS04335	COG4585	Histidine kinase
CAI14_RS04340	COG2197	response regulator
CAI14_RS04355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CAI14_RS04380	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CAI14_RS04390	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CAI14_RS04435	COG0824	Thioesterase
CAI14_RS04440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CAI14_RS04445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CAI14_RS04450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CAI14_RS04455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CAI14_RS04460	COG0268	Binds directly to 16S ribosomal RNA
CAI14_RS04470	COG0196	riboflavin kinase activity
CAI14_RS04475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CAI14_RS04480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CAI14_RS04485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CAI14_RS04500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAI14_RS04505	COG1845	cytochrome c oxidase, subunit III
CAI14_RS04510	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CAI14_RS04525	COG3152	Membrane
CAI14_RS04535	COG2207	Transcriptional regulator
CAI14_RS04540	COG0326	Molecular chaperone. Has ATPase activity
CAI14_RS04555	COG1366	Belongs to the anti-sigma-factor antagonist family
CAI14_RS04560	COG1366	Belongs to the anti-sigma-factor antagonist family
CAI14_RS04565	COG2172	sigma factor antagonist activity
CAI14_RS04590	COG4771	TonB-dependent receptor
CAI14_RS04600	COG5507	3-demethylubiquinone-9 3-methyltransferase
CAI14_RS04605	COG2205	protein histidine kinase activity
CAI14_RS04615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CAI14_RS04620	COG2205	protein histidine kinase activity
CAI14_RS04620	COG4999	Histidine kinase
CAI14_RS04620	COG3850	Histidine kinase
CAI14_RS04620	COG3437	response regulator, receiver
CAI14_RS04665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAI14_RS04670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CAI14_RS04680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAI14_RS04685	COG0228	four-way junction DNA binding
CAI14_RS04690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CAI14_RS04695	COG0336	Belongs to the RNA methyltransferase TrmD family
CAI14_RS04700	COG0335	large ribosomal subunit rRNA binding
CAI14_RS04705	COG0534	Mate efflux family protein
CAI14_RS04725	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CAI14_RS04735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CAI14_RS04760	COG0489	protein tyrosine kinase activity
CAI14_RS04765	COG0717	Belongs to the dCTP deaminase family
CAI14_RS04970	COG3179	chitinase
CAI14_RS05015	COG4695	Portal protein
CAI14_RS05045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CAI14_RS05060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAI14_RS05065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAI14_RS05080	COG0494	nUDIX hydrolase
CAI14_RS05085	COG0433	COG0433 Predicted ATPase
CAI14_RS05095	COG0688	phosphatidylethanolamine metabolic process
CAI14_RS05105	COG2890	protein-(glutamine-N5) methyltransferase activity
CAI14_RS05110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CAI14_RS05115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAI14_RS05120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CAI14_RS05140	COG0101	tRNA pseudouridine synthase activity
CAI14_RS05145	COG0135	phosphoribosylanthranilate isomerase activity
CAI14_RS05155	COG0133	tryptophan synthase activity
CAI14_RS05165	COG0159	tryptophan synthase activity
CAI14_RS05170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CAI14_RS05175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAI14_RS05205	COG0300	oxidoreductase activity
CAI14_RS05210	COG0149	triose-phosphate isomerase activity
CAI14_RS05225	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI14_RS05230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI14_RS05235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI14_RS05240	COG0649	NAD binding
CAI14_RS05245	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CAI14_RS05250	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CAI14_RS05260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CAI14_RS05265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI14_RS05270	COG0839	Belongs to the complex I subunit 6 family
CAI14_RS05290	COG1007	ATP synthesis coupled electron transport
CAI14_RS05300	COG0779	Required for maturation of 30S ribosomal subunits
CAI14_RS05305	COG0195	Participates in both transcription termination and antitermination
CAI14_RS05310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CAI14_RS05315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CAI14_RS05320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CAI14_RS05325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CAI14_RS05330	COG1185	polyribonucleotide nucleotidyltransferase activity
CAI14_RS05365	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CAI14_RS05375	COG2095	MarC family integral membrane protein
CAI14_RS05385	COG1611	Belongs to the LOG family
CAI14_RS05440	COG0556	nucleotide-excision repair
CAI14_RS05455	COG3505	Type IV secretory pathway VirD4
CAI14_RS05475	COG2948	multi-organism process
CAI14_RS05525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CAI14_RS05530	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CAI14_RS05545	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CAI14_RS05550	COG0072	phenylalanine-tRNA ligase activity
CAI14_RS05550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAI14_RS05605	COG0438	transferase activity, transferring glycosyl groups
CAI14_RS05610	COG0438	transferase activity, transferring glycosyl groups
CAI14_RS05620	COG0438	transferase activity, transferring glycosyl groups
CAI14_RS05645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAI14_RS05650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAI14_RS05655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAI14_RS05675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CAI14_RS05685	COG1960	acyl-CoA dehydrogenase activity
CAI14_RS05700	COG3040	lipid binding
CAI14_RS05740	COG0784	Response regulator, receiver
CAI14_RS05740	COG4191	Histidine kinase
CAI14_RS05745	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CAI14_RS05750	COG1194	a g-specific adenine glycosylase
CAI14_RS05755	COG0552	protein localization to endoplasmic reticulum
CAI14_RS05765	COG3938	Belongs to the proline racemase family
CAI14_RS05770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI14_RS05785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAI14_RS05795	COG0006	proline dipeptidase activity
CAI14_RS05810	COG0531	amino acid
CAI14_RS05945	COG0726	polysaccharide deacetylase
CAI14_RS05945	COG1649	PFAM Uncharacterised BCR, COG1649
CAI14_RS06040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAI14_RS06045	COG0124	histidyl-tRNA synthetase
CAI14_RS06055	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CAI14_RS06060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CAI14_RS06065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAI14_RS06070	COG0131	Imidazoleglycerol-phosphate dehydratase
CAI14_RS06070	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CAI14_RS06075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CAI14_RS06080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CAI14_RS06085	COG0107	imidazoleglycerol-phosphate synthase activity
CAI14_RS06090	COG0140	phosphoribosyl-ATP diphosphatase activity
CAI14_RS06090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CAI14_RS06105	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CAI14_RS06110	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CAI14_RS06115	COG0235	Class ii aldolase
CAI14_RS06120	COG0531	amino acid
CAI14_RS06125	COG0531	amino acid
CAI14_RS06135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAI14_RS06140	COG0277	FAD linked oxidase domain protein
CAI14_RS06160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CAI14_RS06210	COG2258	MOSC domain
CAI14_RS06215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CAI14_RS06220	COG0505	Belongs to the CarA family
CAI14_RS06230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CAI14_RS06235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAI14_RS06245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CAI14_RS06300	COG3279	Response regulator of the LytR AlgR family
CAI14_RS06310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CAI14_RS06320	COG2198	Histidine kinase
CAI14_RS06320	COG0784	Response regulator, receiver
CAI14_RS06320	COG2205	protein histidine kinase activity
CAI14_RS06325	COG1024	Enoyl-CoA hydratase
CAI14_RS06355	COG0318	PFAM AMP-dependent synthetase and ligase
CAI14_RS06385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAI14_RS06395	COG2201	protein-glutamate methylesterase activity
CAI14_RS06400	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CAI14_RS06410	COG0840	transmembrane signaling receptor activity
CAI14_RS06420	COG0835	chemotaxis
CAI14_RS06430	COG0840	transmembrane signaling receptor activity
CAI14_RS06435	COG0840	transmembrane signaling receptor activity
CAI14_RS06440	COG0840	transmembrane signaling receptor activity
CAI14_RS06445	COG0840	transmembrane signaling receptor activity
CAI14_RS06450	COG0840	transmembrane signaling receptor activity
CAI14_RS06460	COG0840	transmembrane signaling receptor activity
CAI14_RS06465	COG0840	transmembrane signaling receptor activity
CAI14_RS06475	COG0840	transmembrane signaling receptor activity
CAI14_RS06480	COG0840	transmembrane signaling receptor activity
CAI14_RS06490	COG0840	transmembrane signaling receptor activity
CAI14_RS06505	COG0840	transmembrane signaling receptor activity
CAI14_RS06510	COG2198	Histidine kinase
CAI14_RS06510	COG0643	Histidine kinase
CAI14_RS06515	COG0745	RESPONSE REGULATOR receiver
CAI14_RS06525	COG0835	chemotaxis
CAI14_RS06535	COG1360	Flagellar Motor Protein
CAI14_RS06540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CAI14_RS06565	COG0641	radical SAM
CAI14_RS06575	COG0643	Histidine kinase
CAI14_RS06575	COG0784	Response regulator, receiver
CAI14_RS06575	COG2198	Histidine kinase
CAI14_RS06605	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAI14_RS06630	COG1684	flagellar biosynthetic protein fliR
CAI14_RS06695	COG1677	Flagellar hook-basal body complex protein FliE
CAI14_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS06745	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS06790	COG2201	protein-glutamate methylesterase activity
CAI14_RS06820	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CAI14_RS06830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAI14_RS06835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAI14_RS06845	COG1705	Flagellar rod assembly protein muramidase FlgJ
CAI14_RS06845	COG3951	Flagellar rod assembly protein muramidase FlgJ
CAI14_RS06850	COG1706	bacterial-type flagellum-dependent cell motility
CAI14_RS06855	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CAI14_RS06865	COG4787	bacterial-type flagellum-dependent cell motility
CAI14_RS06875	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CAI14_RS06880	COG1558	bacterial-type flagellum-dependent cell motility
CAI14_RS06890	COG0784	Response regulator, receiver
CAI14_RS06890	COG0835	chemotaxis
CAI14_RS06910	COG5002	protein histidine kinase activity
CAI14_RS06940	COG2915	High frequency lysogenization protein hflD homolog
CAI14_RS06945	COG0482	sulfurtransferase activity
CAI14_RS06960	COG0542	response to heat
CAI14_RS06970	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CAI14_RS06980	COG0492	ferredoxin-NADP+ reductase activity
CAI14_RS06985	COG1674	ftsk spoiiie
CAI14_RS06995	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CAI14_RS07005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CAI14_RS07010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CAI14_RS07015	COG0183	Belongs to the thiolase family
CAI14_RS07020	COG1024	Enoyl-CoA hydratase
CAI14_RS07020	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAI14_RS07035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CAI14_RS07045	COG1426	Protein conserved in bacteria
CAI14_RS07055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAI14_RS07060	COG1160	GTP binding
CAI14_RS07065	COG0303	'Molybdopterin
CAI14_RS07075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CAI14_RS07110	COG0708	Exodeoxyribonuclease III
CAI14_RS07125	COG0746	molybdenum cofactor guanylyltransferase activity
CAI14_RS07135	COG1648	precorrin-2 dehydrogenase activity
CAI14_RS07135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAI14_RS07170	COG3685	Protein conserved in bacteria
CAI14_RS07200	COG4566	intracellular signal transduction
CAI14_RS07220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI14_RS07245	COG0477	Major facilitator Superfamily
CAI14_RS07255	COG2205	protein histidine kinase activity
CAI14_RS07255	COG0784	Response regulator, receiver
CAI14_RS07255	COG5002	protein histidine kinase activity
CAI14_RS07260	COG2733	membrane
CAI14_RS07270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CAI14_RS07275	COG2223	nitrite transmembrane transporter activity
CAI14_RS07280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CAI14_RS07285	COG0243	molybdopterin cofactor binding
CAI14_RS07295	COG0477	Major facilitator Superfamily
CAI14_RS07300	COG2703	oxygen carrier activity
CAI14_RS07310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI14_RS07315	COG0174	glutamine synthetase
CAI14_RS07320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CAI14_RS07335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CAI14_RS07355	COG3842	ATPase activity
CAI14_RS07360	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAI14_RS07365	COG1177	transmembrane transport
CAI14_RS07370	COG1012	belongs to the aldehyde dehydrogenase family
CAI14_RS07385	COG4535	Mg2 and Co2 transporter CorC
CAI14_RS07395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CAI14_RS07405	COG1702	phosphate starvation-inducible protein PhoH
CAI14_RS07410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAI14_RS07425	COG0741	lytic transglycosylase activity
CAI14_RS07435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CAI14_RS07440	COG2857	Cytochrome c1
CAI14_RS07445	COG0625	glutathione transferase activity
CAI14_RS07450	COG2969	positive regulation of protein catabolic process
CAI14_RS07470	COG1201	RNA secondary structure unwinding
CAI14_RS07475	COG2094	Belongs to the DNA glycosylase MPG family
CAI14_RS07480	COG0840	transmembrane signaling receptor activity
CAI14_RS07485	COG0835	chemotaxis
CAI14_RS07530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAI14_RS07540	COG1570	exodeoxyribonuclease VII activity
CAI14_RS07545	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CAI14_RS07550	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CAI14_RS07550	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CAI14_RS07555	COG0802	atpase or kinase
CAI14_RS07560	COG0860	N-Acetylmuramoyl-L-alanine amidase
CAI14_RS07565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CAI14_RS07595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAI14_RS07605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI14_RS07640	COG2081	HI0933 family
CAI14_RS07645	COG4681	YaeQ
CAI14_RS07655	COG0625	glutathione transferase activity
CAI14_RS07665	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CAI14_RS07670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CAI14_RS07675	COG0513	Belongs to the DEAD box helicase family
CAI14_RS07680	COG0488	(ABC) transporter
CAI14_RS07695	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CAI14_RS07700	COG0483	inositol monophosphate 1-phosphatase activity
CAI14_RS07715	COG5001	Diguanylate cyclase
CAI14_RS07715	COG3300	MHYT domain
CAI14_RS07720	COG1509	lysine 2,3-aminomutase activity
CAI14_RS07725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CAI14_RS07735	COG0402	S-adenosylhomocysteine deaminase activity
CAI14_RS07740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAI14_RS07800	COG4302	ethanolamine ammonia-lyase activity
CAI14_RS07830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAI14_RS07835	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CAI14_RS07850	COG2166	iron-sulfur cluster assembly
CAI14_RS07855	COG0215	cysteine-tRNA ligase activity
CAI14_RS07865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CAI14_RS07870	COG0137	argininosuccinate synthase activity
CAI14_RS07880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAI14_RS07885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CAI14_RS07895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CAI14_RS07900	COG0165	Argininosuccinate lyase
CAI14_RS07910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CAI14_RS07915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CAI14_RS07935	COG3344	reverse transcriptase
CAI14_RS07945	COG1294	oxidase, subunit
CAI14_RS07955	COG4988	ABC transporter
CAI14_RS07960	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CAI14_RS07965	COG1278	Cold shock
CAI14_RS07970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAI14_RS07990	COG1138	Cytochrome C-type biogenesis protein
CAI14_RS07995	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CAI14_RS08015	COG4133	protoheme IX ABC transporter activity
CAI14_RS08020	COG0436	Aminotransferase
CAI14_RS08040	COG1187	pseudouridine synthase activity
CAI14_RS08045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CAI14_RS08050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CAI14_RS08055	COG2350	Protein conserved in bacteria
CAI14_RS08085	COG1175	transmembrane transport
CAI14_RS08090	COG0395	ABC-type sugar transport system, permease component
CAI14_RS08115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAI14_RS08120	COG2957	Belongs to the agmatine deiminase family
CAI14_RS08135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CAI14_RS08140	COG0539	negative regulation of cytoplasmic translation
CAI14_RS08145	COG0776	regulation of translation
CAI14_RS08155	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CAI14_RS08160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAI14_RS08170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CAI14_RS08175	COG0475	glutathione-regulated potassium exporter activity
CAI14_RS08175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAI14_RS08185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CAI14_RS08195	COG0519	Catalyzes the synthesis of GMP from XMP
CAI14_RS08195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAI14_RS08200	COG3002	Belongs to the UPF0753 family
CAI14_RS08205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAI14_RS08210	COG0583	DNA-binding transcription factor activity
CAI14_RS08230	COG2197	response regulator
CAI14_RS08250	COG1335	isochorismatase
CAI14_RS08275	COG2814	Major facilitator Superfamily
CAI14_RS08295	COG1914	H( )-stimulated, divalent metal cation uptake system
CAI14_RS08310	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CAI14_RS08335	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI14_RS08420	COG4456	Virulence-associated protein
CAI14_RS08435	COG0668	transmembrane transport
CAI14_RS08445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CAI14_RS08460	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS08465	COG1183	phosphatidylcholine synthase activity
CAI14_RS08475	COG3243	poly(R)-hydroxyalkanoic acid synthase
CAI14_RS08490	COG0723	plastoquinol--plastocyanin reductase activity
CAI14_RS08490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI14_RS08500	COG2183	response to ionizing radiation
CAI14_RS08505	COG0784	Response regulator, receiver
CAI14_RS08505	COG2205	protein histidine kinase activity
CAI14_RS08570	COG0800	Aldolase
CAI14_RS08575	COG0129	dihydroxy-acid dehydratase activity
CAI14_RS08580	COG0363	glucosamine-6-phosphate deaminase activity
CAI14_RS08585	COG0837	glucose binding
CAI14_RS08590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CAI14_RS08615	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CAI14_RS08635	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CAI14_RS08645	COG4591	ABC-type transport system involved in lipoprotein release permease component
CAI14_RS08650	COG1136	(ABC) transporter
CAI14_RS08665	COG0811	peptide transport
CAI14_RS08675	COG1132	(ABC) transporter
CAI14_RS08680	COG1663	tetraacyldisaccharide 4'-kinase activity
CAI14_RS08685	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CAI14_RS08690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CAI14_RS08700	COG0322	excinuclease ABC activity
CAI14_RS08705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAI14_RS08785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAI14_RS08815	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CAI14_RS08835	COG1054	Belongs to the UPF0176 family
CAI14_RS08845	COG1530	ribonuclease E activity
CAI14_RS08855	COG3064	Membrane
CAI14_RS08860	COG0428	transporter
CAI14_RS08870	COG2154	pterin-4-alpha-carbinolamine dehydratase
CAI14_RS08875	COG0316	Belongs to the HesB IscA family
CAI14_RS08875	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CAI14_RS08960	COG2226	methyltransferase
CAI14_RS08960	COG1073	alpha beta
CAI14_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS09010	COG1238	metal cluster binding
CAI14_RS09045	COG2902	Dehydrogenase
CAI14_RS09055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI14_RS09060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI14_RS09070	COG1609	Transcriptional regulator
CAI14_RS09075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAI14_RS09075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAI14_RS09080	COG1105	Belongs to the carbohydrate kinase PfkB family
CAI14_RS09085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAI14_RS09085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAI14_RS09120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAI14_RS09130	COG1862	Preprotein translocase
CAI14_RS09135	COG0343	queuine tRNA-ribosyltransferase activity
CAI14_RS09140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CAI14_RS09175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CAI14_RS09180	COG3291	Pkd domain containing protein
CAI14_RS09185	COG0405	Gamma-glutamyltransferase
CAI14_RS09190	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CAI14_RS09200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CAI14_RS09205	COG0742	ribosomal rna small subunit methyltransferase
CAI14_RS09210	COG0326	Molecular chaperone. Has ATPase activity
CAI14_RS09240	COG1012	belongs to the aldehyde dehydrogenase family
CAI14_RS09255	COG0167	dihydroorotate dehydrogenase activity
CAI14_RS09260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CAI14_RS09290	COG0671	phosphoesterase, PA-phosphatase related
CAI14_RS09305	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CAI14_RS09310	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI14_RS09315	COG3706	GGDEF domain
CAI14_RS09315	COG2203	Gaf domain
CAI14_RS09315	COG5001	Diguanylate cyclase
CAI14_RS09315	COG4251	negative regulation of phosphorylation
CAI14_RS09325	COG1472	Belongs to the glycosyl hydrolase 3 family
CAI14_RS09350	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CAI14_RS09355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CAI14_RS09360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CAI14_RS09380	COG1469	GTP cyclohydrolase I activity
CAI14_RS09385	COG0860	N-Acetylmuramoyl-L-alanine amidase
CAI14_RS09400	COG0477	Major facilitator Superfamily
CAI14_RS09405	COG2115	Belongs to the xylose isomerase family
CAI14_RS09410	COG1070	Carbohydrate kinase
CAI14_RS09420	COG1501	Belongs to the glycosyl hydrolase 31 family
CAI14_RS09455	COG0800	Aldolase
CAI14_RS09460	COG4948	Mandelate Racemase Muconate Lactonizing
CAI14_RS09470	COG3734	2-keto-3-deoxy-galactonokinase
CAI14_RS09475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CAI14_RS09485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAI14_RS09500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CAI14_RS09505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CAI14_RS09520	COG0351	phosphomethylpyrimidine kinase
CAI14_RS09545	COG0583	DNA-binding transcription factor activity
CAI14_RS09550	COG1741	Belongs to the pirin family
CAI14_RS09565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CAI14_RS09570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CAI14_RS09575	COG2137	regulation of response to DNA damage stimulus
CAI14_RS09580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CAI14_RS09585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CAI14_RS09595	COG1546	Belongs to the CinA family
CAI14_RS09600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CAI14_RS09610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CAI14_RS09615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CAI14_RS09625	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CAI14_RS09630	COG1534	Rna-binding protein
CAI14_RS09645	COG1238	metal cluster binding
CAI14_RS09650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAI14_RS09655	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CAI14_RS09660	COG2840	Smr protein MutS2
CAI14_RS09665	COG0585	pseudouridine synthase activity
CAI14_RS09670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CAI14_RS09675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CAI14_RS09680	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CAI14_RS09685	COG0148	phosphopyruvate hydratase activity
CAI14_RS09695	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CAI14_RS09700	COG0504	CTP synthase activity
CAI14_RS09725	COG0306	phosphate transporter
CAI14_RS09735	COG1253	flavin adenine dinucleotide binding
CAI14_RS09750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAI14_RS09755	COG0477	Major facilitator Superfamily
CAI14_RS09760	COG1132	(ABC) transporter
CAI14_RS09765	COG1136	(ABC) transporter
CAI14_RS09790	COG2264	protein methyltransferase activity
CAI14_RS09820	COG2244	polysaccharide biosynthetic process
CAI14_RS09870	COG1595	DNA-templated transcription, initiation
CAI14_RS09885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAI14_RS09895	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CAI14_RS09905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAI14_RS09920	COG4191	Histidine kinase
CAI14_RS09920	COG0784	Response regulator, receiver
CAI14_RS09925	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CAI14_RS09950	COG0840	transmembrane signaling receptor activity
CAI14_RS09980	COG0583	DNA-binding transcription factor activity
CAI14_RS09985	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAI14_RS09990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CAI14_RS10005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CAI14_RS10010	COG0077	Prephenate dehydratase
CAI14_RS10010	COG1605	Chorismate mutase
CAI14_RS10015	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CAI14_RS10020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAI14_RS10025	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CAI14_RS10065	COG1228	amidohydrolase
CAI14_RS10070	COG2986	histidine ammonia-lyase
CAI14_RS10080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CAI14_RS10090	COG4993	Dehydrogenase
CAI14_RS10100	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CAI14_RS10110	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CAI14_RS10115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CAI14_RS10120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAI14_RS10130	COG3115	cell septum assembly
CAI14_RS10140	COG0359	binds to the 23S rRNA
CAI14_RS10145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CAI14_RS10150	COG0360	Binds together with S18 to 16S ribosomal RNA
CAI14_RS10155	COG0316	Belongs to the HesB IscA family
CAI14_RS10160	COG0017	Asparaginyl-tRNA synthetase
CAI14_RS10180	COG2808	Putative FMN-binding domain
CAI14_RS10245	COG0288	reversible hydration of carbon dioxide
CAI14_RS10250	COG0662	Cupin 2, conserved barrel domain protein
CAI14_RS10260	COG3844	kynureninase activity
CAI14_RS10265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAI14_RS10275	COG2925	Exonuclease
CAI14_RS10300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CAI14_RS10305	COG0116	Belongs to the methyltransferase superfamily
CAI14_RS10305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CAI14_RS10350	COG0494	nUDIX hydrolase
CAI14_RS10360	COG1024	Enoyl-CoA hydratase
CAI14_RS10370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CAI14_RS10375	COG0659	secondary active sulfate transmembrane transporter activity
CAI14_RS10400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CAI14_RS10405	COG0573	inorganic phosphate transmembrane transporter activity
CAI14_RS10410	COG0581	inorganic phosphate transmembrane transporter activity
CAI14_RS10415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAI14_RS10420	COG0704	Plays a role in the regulation of phosphate uptake
CAI14_RS10430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAI14_RS10440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAI14_RS10450	COG0557	exoribonuclease II activity
CAI14_RS10465	COG1960	acyl-CoA dehydrogenase activity
CAI14_RS10470	COG1960	acyl-CoA dehydrogenase activity
CAI14_RS10475	COG2226	methyltransferase
CAI14_RS10480	COG1410	methionine synthase
CAI14_RS10480	COG0646	methionine synthase
CAI14_RS10505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAI14_RS10530	COG2900	Belongs to the SlyX family
CAI14_RS10545	COG0386	Belongs to the glutathione peroxidase family
CAI14_RS10555	COG1725	Transcriptional regulator
CAI14_RS10560	COG1131	(ABC) transporter
CAI14_RS10590	COG1253	flavin adenine dinucleotide binding
CAI14_RS10645	COG1132	(ABC) transporter
CAI14_RS10650	COG0583	DNA-binding transcription factor activity
CAI14_RS10685	COG0484	heat shock protein binding
CAI14_RS10690	COG0443	Heat shock 70 kDa protein
CAI14_RS10695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CAI14_RS10700	COG1420	regulation of RNA biosynthetic process
CAI14_RS10705	COG0497	DNA recombination
CAI14_RS10715	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAI14_RS10730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CAI14_RS10755	COG3706	GGDEF domain
CAI14_RS10800	COG0583	DNA-binding transcription factor activity
CAI14_RS10810	COG0415	Belongs to the DNA photolyase family
CAI14_RS10815	COG0305	Participates in initiation and elongation during chromosome replication
CAI14_RS10825	COG0367	asparagine synthase
CAI14_RS10845	COG1960	acyl-CoA dehydrogenase activity
CAI14_RS10860	COG0084	hydrolase, TatD family'
CAI14_RS10865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CAI14_RS10925	COG0386	Belongs to the glutathione peroxidase family
CAI14_RS10930	COG0339	signal peptide processing
CAI14_RS10985	COG2814	Major facilitator Superfamily
CAI14_RS10990	COG1566	PFAM secretion protein HlyD family protein
CAI14_RS11030	COG4774	siderophore transport
CAI14_RS11040	COG0367	asparagine synthase
CAI14_RS11045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAI14_RS11050	COG1393	Belongs to the ArsC family
CAI14_RS11060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CAI14_RS11100	COG0052	Belongs to the universal ribosomal protein uS2 family
CAI14_RS11105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CAI14_RS11115	COG0528	UMP kinase activity
CAI14_RS11120	COG0233	cytoplasmic translational termination
CAI14_RS11125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAI14_RS11130	COG0575	Belongs to the CDS family
CAI14_RS11135	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CAI14_RS11140	COG0750	zinc metalloprotease
CAI14_RS11155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAI14_RS11160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAI14_RS11165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAI14_RS11170	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAI14_RS11175	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CAI14_RS11185	COG0825	malonyl-CoA metabolic process
CAI14_RS11200	COG1981	membrane
CAI14_RS11220	COG1695	Transcriptional regulator
CAI14_RS11240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CAI14_RS11250	COG2040	homocysteine
CAI14_RS11255	COG0833	amino acid
CAI14_RS11260	COG0346	lactoylglutathione lyase activity
CAI14_RS11265	COG1131	(ABC) transporter
CAI14_RS11280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAI14_RS11280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAI14_RS11290	COG2878	Part of a membrane complex involved in electron transport
CAI14_RS11305	COG1595	DNA-templated transcription, initiation
CAI14_RS11330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAI14_RS11345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAI14_RS11350	COG0251	oxidation-reduction process
CAI14_RS11360	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CAI14_RS11360	COG0392	lysyltransferase activity
CAI14_RS11395	COG2814	Major facilitator Superfamily
CAI14_RS11405	COG2824	Alkylphosphonate utilization operon protein PhnA
CAI14_RS11415	COG1047	Peptidyl-prolyl cis-trans
CAI14_RS11435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CAI14_RS11445	COG5487	UPF0391 membrane protein
CAI14_RS11450	COG1451	nucleotide metabolic process
CAI14_RS11475	COG0183	Belongs to the thiolase family
CAI14_RS11505	COG1793	dna ligase
CAI14_RS11505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CAI14_RS11515	COG1793	dna ligase
CAI14_RS11520	COG1201	RNA secondary structure unwinding
CAI14_RS11535	COG1278	Cold shock
CAI14_RS11545	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CAI14_RS11550	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CAI14_RS11555	COG1472	Belongs to the glycosyl hydrolase 3 family
CAI14_RS11560	COG3046	protein related to deoxyribodipyrimidine photolyase
CAI14_RS11565	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CAI14_RS11570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CAI14_RS11575	COG2954	triphosphatase activity
CAI14_RS11585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAI14_RS11595	COG1381	Involved in DNA repair and RecF pathway recombination
CAI14_RS11600	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CAI14_RS11605	COG0571	ribonuclease III activity
CAI14_RS11620	COG0481	GTPase activity
CAI14_RS11625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAI14_RS11660	COG1024	Enoyl-CoA hydratase
CAI14_RS11665	COG1960	acyl-CoA dehydrogenase activity
CAI14_RS11685	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CAI14_RS11690	COG3250	beta-galactosidase activity
CAI14_RS11740	COG3209	COG3209 Rhs family protein
CAI14_RS11805	COG3590	peptidase
CAI14_RS11810	COG3590	peptidase
CAI14_RS11835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAI14_RS11840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI14_RS11845	COG2311	Membrane
CAI14_RS11850	COG1047	Peptidyl-prolyl cis-trans
CAI14_RS11855	COG0791	NLP P60 protein
CAI14_RS11860	COG0791	NLP P60 protein
CAI14_RS11870	COG4106	trans-aconitate 2-methyltransferase activity
CAI14_RS11875	COG1301	dicarboxylic acid transport
CAI14_RS11880	COG1785	Belongs to the alkaline phosphatase family
CAI14_RS11885	COG0037	tRNA processing
CAI14_RS11890	COG1722	exodeoxyribonuclease VII activity
CAI14_RS11895	COG0142	geranyltranstransferase activity
CAI14_RS11940	COG0312	modulator of DNA gyrase
CAI14_RS11945	COG3028	Belongs to the UPF0307 family
CAI14_RS11950	COG0312	modulator of DNA gyrase
CAI14_RS11960	COG3164	Protein of unknown function
CAI14_RS11970	COG0424	maF-like protein
CAI14_RS11975	COG2968	Membrane
CAI14_RS11995	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CAI14_RS12010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CAI14_RS12025	COG0495	leucyl-tRNA aminoacylation
CAI14_RS12035	COG3118	belongs to the thioredoxin family
CAI14_RS12065	COG2155	Conserved Protein
CAI14_RS12110	COG1132	(ABC) transporter
CAI14_RS12140	COG1538	Outer membrane efflux protein
CAI14_RS12145	COG0745	RESPONSE REGULATOR receiver
CAI14_RS12150	COG5000	phosphorelay sensor kinase activity
CAI14_RS12150	COG5002	protein histidine kinase activity
CAI14_RS12155	COG0475	glutathione-regulated potassium exporter activity
CAI14_RS12165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAI14_RS12185	COG1187	pseudouridine synthase activity
CAI14_RS12190	COG5002	protein histidine kinase activity
CAI14_RS12190	COG5001	Diguanylate cyclase
CAI14_RS12240	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CAI14_RS12325	COG2814	Major facilitator Superfamily
CAI14_RS12360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI14_RS12375	COG0735	belongs to the Fur family
CAI14_RS12380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAI14_RS12405	COG4452	Inner membrane protein CreD
CAI14_RS12415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CAI14_RS12430	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CAI14_RS12440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CAI14_RS12455	COG0643	Histidine kinase
CAI14_RS12455	COG2198	Histidine kinase
CAI14_RS12460	COG0840	transmembrane signaling receptor activity
CAI14_RS12465	COG0835	chemotaxis
CAI14_RS12470	COG2199	diguanylate cyclase activity
CAI14_RS12470	COG2202	Pas domain
CAI14_RS12470	COG2200	EAL domain
CAI14_RS12475	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CAI14_RS12480	COG2201	protein-glutamate methylesterase activity
CAI14_RS12485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI14_RS12500	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CAI14_RS12535	COG4181	ATPase activity
CAI14_RS12545	COG2175	clavaminate synthase activity
CAI14_RS12555	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CAI14_RS12560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAI14_RS12580	COG4771	TonB-dependent receptor
CAI14_RS12590	COG0667	Aldo Keto reductase
CAI14_RS12595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CAI14_RS12600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAI14_RS12610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CAI14_RS12615	COG4106	trans-aconitate 2-methyltransferase activity
CAI14_RS12625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CAI14_RS12675	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CAI14_RS12685	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CAI14_RS12690	COG2226	methyltransferase
CAI14_RS12720	COG0366	Alpha amylase catalytic
CAI14_RS12745	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS12745	COG0604	alcohol dehydrogenase
CAI14_RS12745	COG3321	synthase
CAI14_RS12755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CAI14_RS12765	COG0494	nUDIX hydrolase
CAI14_RS12770	COG0653	protein targeting
CAI14_RS12785	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CAI14_RS12800	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CAI14_RS12805	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAI14_RS12810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CAI14_RS12815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CAI14_RS12825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAI14_RS12830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CAI14_RS12835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CAI14_RS12845	COG3116	cell division
CAI14_RS12850	COG0275	rRNA processing
CAI14_RS12890	COG0792	nuclease activity
CAI14_RS12895	COG1988	membrane-bound metal-dependent
CAI14_RS12900	COG0277	FAD linked oxidase domain protein
CAI14_RS12935	COG0745	RESPONSE REGULATOR receiver
CAI14_RS12940	COG2205	protein histidine kinase activity
CAI14_RS12945	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CAI14_RS12950	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CAI14_RS12955	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CAI14_RS12975	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CAI14_RS12980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAI14_RS12985	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CAI14_RS13005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAI14_RS13005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAI14_RS13015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CAI14_RS13020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CAI14_RS13030	COG0488	(ABC) transporter
CAI14_RS13040	COG0697	spore germination
CAI14_RS13050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAI14_RS13065	COG3791	Glutathione-dependent formaldehyde-activating
CAI14_RS13095	COG2205	protein histidine kinase activity
CAI14_RS13110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CAI14_RS13115	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CAI14_RS13145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CAI14_RS13150	COG1012	belongs to the aldehyde dehydrogenase family
CAI14_RS13155	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CAI14_RS13160	COG0617	tRNA 3'-terminal CCA addition
CAI14_RS13170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CAI14_RS13175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAI14_RS13180	COG1609	Transcriptional regulator
CAI14_RS13190	COG2188	Transcriptional regulator
CAI14_RS13205	COG3250	beta-galactosidase activity
CAI14_RS13235	COG4795	General secretion pathway protein
CAI14_RS13255	COG1459	type II secretion system
CAI14_RS13310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CAI14_RS13315	COG4191	Histidine kinase
CAI14_RS13320	COG0784	Response regulator, receiver
CAI14_RS13325	COG4251	negative regulation of phosphorylation
CAI14_RS13330	COG2823	Periplasmic or secreted lipoprotein
CAI14_RS13335	COG0673	inositol 2-dehydrogenase activity
CAI14_RS13340	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CAI14_RS13375	COG1056	cytidyltransferase-related domain
CAI14_RS13375	COG1051	belongs to the nudix hydrolase family
CAI14_RS13385	COG0583	DNA-binding transcription factor activity
CAI14_RS13400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CAI14_RS13405	COG0321	lipoyl(octanoyl) transferase activity
CAI14_RS13410	COG2921	Belongs to the UPF0250 family
CAI14_RS13420	COG1686	Belongs to the peptidase S11 family
CAI14_RS13425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CAI14_RS13430	COG2951	lytic endotransglycosylase activity
CAI14_RS13440	COG0772	Belongs to the SEDS family
CAI14_RS13455	COG1792	Involved in formation and maintenance of cell shape
CAI14_RS13460	COG1077	Cell shape determining protein MreB Mrl
CAI14_RS13465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAI14_RS13470	COG3284	Transcriptional regulator
CAI14_RS13490	COG2010	Cytochrome c
CAI14_RS13580	COG5002	protein histidine kinase activity
CAI14_RS13585	COG0745	RESPONSE REGULATOR receiver
CAI14_RS13595	COG0189	ligase activity
CAI14_RS13635	COG2022	thiamine diphosphate biosynthetic process
CAI14_RS13640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CAI14_RS13645	COG3273	potassium ion transport
CAI14_RS13645	COG0471	metal ion transport
CAI14_RS13665	COG1970	mechanosensitive ion channel activity
CAI14_RS13675	COG1609	Transcriptional regulator
CAI14_RS13685	COG3250	beta-galactosidase activity
CAI14_RS13690	COG4948	Mandelate Racemase Muconate Lactonizing
CAI14_RS13705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAI14_RS13755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI14_RS13760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI14_RS13765	COG2895	sulfate adenylyltransferase (ATP) activity
CAI14_RS13765	COG0529	Catalyzes the synthesis of activated sulfate
CAI14_RS13770	COG0175	sulfate reduction
CAI14_RS13775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CAI14_RS13780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAI14_RS13785	COG0175	sulfate reduction
CAI14_RS13805	COG0784	Response regulator, receiver
CAI14_RS13805	COG2198	Histidine kinase
CAI14_RS13805	COG2205	protein histidine kinase activity
CAI14_RS13820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAI14_RS13820	COG1648	precorrin-2 dehydrogenase activity
CAI14_RS13835	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CAI14_RS13840	COG3588	fructose-bisphosphate aldolase
CAI14_RS13845	COG0469	pyruvate kinase activity
CAI14_RS13855	COG0126	phosphoglycerate kinase activity
CAI14_RS13875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CAI14_RS13890	COG3047	cAMP biosynthetic process
CAI14_RS13895	COG3047	cAMP biosynthetic process
CAI14_RS13905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAI14_RS13905	COG3453	Protein conserved in bacteria
CAI14_RS13910	COG0725	ABC transporter, periplasmic molybdate-binding protein
CAI14_RS13915	COG4149	molybdate abc transporter
CAI14_RS13920	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CAI14_RS13955	COG1376	ErfK ybiS ycfS ynhG family protein
CAI14_RS13965	COG0739	heme binding
CAI14_RS13975	COG4773	Receptor
CAI14_RS13980	COG0596	Alpha beta hydrolase
CAI14_RS13985	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CAI14_RS13990	COG1301	dicarboxylic acid transport
CAI14_RS14000	COG2304	oxidoreductase activity
CAI14_RS14020	COG0714	Associated with various cellular activities
CAI14_RS14050	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CAI14_RS14080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CAI14_RS14090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAI14_RS14095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAI14_RS14100	COG2390	Transcriptional regulator
CAI14_RS14115	COG3659	wide pore channel activity
CAI14_RS14135	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS14140	COG1070	Carbohydrate kinase
CAI14_RS14150	COG0194	GDP metabolic process
CAI14_RS14155	COG1561	YicC-like family, N-terminal region
CAI14_RS14160	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CAI14_RS14170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CAI14_RS14175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CAI14_RS14190	COG0006	proline dipeptidase activity
CAI14_RS14200	COG0006	proline dipeptidase activity
CAI14_RS14205	COG3079	Belongs to the UPF0149 family
CAI14_RS14225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CAI14_RS14235	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CAI14_RS14245	COG2912	Transglutaminase-like superfamily
CAI14_RS14250	COG1773	rubredoxin
CAI14_RS14255	COG0352	thiamine-phosphate diphosphorylase activity
CAI14_RS14265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CAI14_RS14280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAI14_RS14310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAI14_RS14315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAI14_RS14325	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS14335	COG0671	phosphoesterase, PA-phosphatase related
CAI14_RS14340	COG3781	membrane
CAI14_RS14350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CAI14_RS14355	COG0563	adenylate kinase activity
CAI14_RS14380	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CAI14_RS14390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CAI14_RS14420	COG3710	Transcriptional regulator
CAI14_RS14425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CAI14_RS14435	COG0840	transmembrane signaling receptor activity
CAI14_RS14445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CAI14_RS14465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAI14_RS14470	COG0473	3-isopropylmalate dehydrogenase activity
CAI14_RS14475	COG0066	3-isopropylmalate dehydratase activity
CAI14_RS14480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAI14_RS14500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAI14_RS14505	COG1538	Outer membrane efflux protein
CAI14_RS14510	COG1519	Transferase
CAI14_RS14515	COG1560	Kdo2-lipid A biosynthetic process
CAI14_RS14540	COG0281	malic enzyme
CAI14_RS14540	COG0280	phosphate acetyltransferase
CAI14_RS14545	COG1301	dicarboxylic acid transport
CAI14_RS14575	COG0583	DNA-binding transcription factor activity
CAI14_RS14580	COG0667	Aldo Keto reductase
CAI14_RS14600	COG2197	response regulator
CAI14_RS14610	COG0642	Histidine kinase
CAI14_RS14625	COG2851	Citrate transporter
CAI14_RS14630	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS14635	COG1609	Transcriptional regulator
CAI14_RS14665	COG1162	GTPase activity
CAI14_RS14695	COG0308	aminopeptidase N
CAI14_RS14700	COG5001	Diguanylate cyclase
CAI14_RS14700	COG3300	MHYT domain
CAI14_RS14705	COG2226	methyltransferase
CAI14_RS14730	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CAI14_RS14735	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CAI14_RS14740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CAI14_RS14750	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CAI14_RS14760	COG2832	Protein of unknown function (DUF454)
CAI14_RS14770	COG0436	Aminotransferase
CAI14_RS14780	COG1505	serine-type exopeptidase activity
CAI14_RS14815	COG0181	hydroxymethylbilane synthase activity
CAI14_RS14825	COG3275	phosphorelay sensor kinase activity
CAI14_RS14835	COG2943	transferase activity, transferring hexosyl groups
CAI14_RS14850	COG0659	secondary active sulfate transmembrane transporter activity
CAI14_RS14855	COG5297	Belongs to the glycosyl hydrolase family 6
CAI14_RS14855	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI14_RS14860	COG0840	transmembrane signaling receptor activity
CAI14_RS14870	COG5001	Diguanylate cyclase
CAI14_RS14915	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CAI14_RS14935	COG1113	amino acid transport
CAI14_RS14950	COG0697	spore germination
CAI14_RS14985	COG1506	peptidase
CAI14_RS14985	COG0823	Involved in the tonB-independent uptake of proteins
CAI14_RS14995	COG2409	Drug exporters of the RND superfamily
CAI14_RS15020	COG0435	Glutathione S-transferase
CAI14_RS15030	COG4221	oxidoreductase activity
CAI14_RS15045	COG4221	oxidoreductase activity
CAI14_RS15120	COG1802	Transcriptional regulator
CAI14_RS15155	COG3052	prosthetic group binding
CAI14_RS15185	COG2353	YceI-like domain
CAI14_RS15190	COG0778	Nitroreductase
CAI14_RS15205	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CAI14_RS15210	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CAI14_RS15220	COG3386	PFAM SMP-30 Gluconolaconase
CAI14_RS15235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CAI14_RS15250	COG0459	protein refolding
CAI14_RS15260	COG2356	endonuclease I
CAI14_RS15270	COG0300	oxidoreductase activity
CAI14_RS15295	COG1324	tolerance protein
CAI14_RS15305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CAI14_RS15310	COG0511	ligase activity, forming carbon-carbon bonds
CAI14_RS15320	COG0439	Biotin carboxylase
CAI14_RS15335	COG2264	protein methyltransferase activity
CAI14_RS15355	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CAI14_RS15360	COG4589	Belongs to the CDS family
CAI14_RS15385	COG2453	phosphatase
CAI14_RS15385	COG0671	phosphoesterase, PA-phosphatase related
CAI14_RS15390	COG2267	carboxylic ester hydrolase activity
CAI14_RS15395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAI14_RS15400	COG0138	bifunctional purine biosynthesis protein purh
CAI14_RS15410	COG0151	Belongs to the GarS family
CAI14_RS15420	COG1289	transmembrane transporter activity
CAI14_RS15425	COG2814	Major facilitator Superfamily
CAI14_RS15435	COG2814	Major facilitator Superfamily
CAI14_RS15450	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CAI14_RS15465	COG0316	Belongs to the HesB IscA family
CAI14_RS15505	COG1051	belongs to the nudix hydrolase family
CAI14_RS15520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CAI14_RS15530	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CAI14_RS15540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CAI14_RS15545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAI14_RS15555	COG0134	indole-3-glycerol-phosphate synthase activity
CAI14_RS15560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CAI14_RS15585	COG1597	lipid kinase activity
CAI14_RS15590	COG0456	acetyltransferase
CAI14_RS15605	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CAI14_RS15610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CAI14_RS15630	COG3179	chitinase
CAI14_RS15650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAI14_RS15650	COG2111	Na H antiporter
CAI14_RS15655	COG1006	Multisubunit Na H antiporter MnhC subunit
CAI14_RS15660	COG0651	ATP synthesis coupled electron transport
CAI14_RS15670	COG2212	antiporter activity
CAI14_RS15675	COG1320	monovalent cation:proton antiporter activity
CAI14_RS15690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CAI14_RS15715	COG3104	oligopeptide transport
CAI14_RS15720	COG3483	tryptophan 2,3-dioxygenase activity
CAI14_RS15730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CAI14_RS15750	COG0513	Belongs to the DEAD box helicase family
CAI14_RS15760	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS15765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI14_RS15800	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS15805	COG0702	epimerase
CAI14_RS15830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAI14_RS15835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAI14_RS15840	COG0297	glycogen (starch) synthase activity
CAI14_RS15850	COG2354	Protein conserved in bacteria
CAI14_RS15855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAI14_RS15860	COG1368	sulfuric ester hydrolase activity
CAI14_RS15865	COG1511	domain protein
CAI14_RS15865	COG3264	Mechanosensitive ion channel
CAI14_RS15935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAI14_RS16020	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CAI14_RS16025	COG1040	competence protein
CAI14_RS16030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CAI14_RS16035	COG0156	8-amino-7-oxononanoate synthase activity
CAI14_RS16045	COG2267	carboxylic ester hydrolase activity
CAI14_RS16075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CAI14_RS16085	COG0445	tRNA wobble uridine modification
CAI14_RS16095	COG0657	acetylesterase activity
CAI14_RS16105	COG1414	Transcriptional regulator
CAI14_RS16115	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAI14_RS16120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAI14_RS16135	COG3485	protocatechuate 3,4-dioxygenase
CAI14_RS16145	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CAI14_RS16150	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CAI14_RS16175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CAI14_RS16180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CAI14_RS16235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CAI14_RS16250	COG0129	dihydroxy-acid dehydratase activity
CAI14_RS16295	COG1733	regulation of RNA biosynthetic process
CAI14_RS16300	COG0702	epimerase
CAI14_RS16330	COG0583	DNA-binding transcription factor activity
CAI14_RS16335	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CAI14_RS16360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI14_RS16365	COG2205	protein histidine kinase activity
CAI14_RS16370	COG0745	RESPONSE REGULATOR receiver
CAI14_RS16390	COG1902	pentaerythritol trinitrate reductase activity
CAI14_RS16395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CAI14_RS16410	COG2814	Major facilitator Superfamily
CAI14_RS16415	COG0583	DNA-binding transcription factor activity
CAI14_RS16435	COG0084	hydrolase, TatD family'
CAI14_RS16455	COG2252	PERMEase
CAI14_RS16465	COG1957	nucleoside hydrolase
CAI14_RS16500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CAI14_RS16520	COG2072	flavoprotein involved in K transport
CAI14_RS16525	COG2351	hydroxyisourate hydrolase activity
CAI14_RS16530	COG4807	Protein conserved in bacteria
CAI14_RS16535	COG1643	Atp-dependent helicase
CAI14_RS16550	COG1187	pseudouridine synthase activity
CAI14_RS16565	COG2130	NADP-dependent
CAI14_RS16590	COG1764	response to oxidative stress
CAI14_RS16595	COG1846	Transcriptional regulator
CAI14_RS16600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CAI14_RS16620	COG0523	cobalamin synthesis protein
CAI14_RS16675	COG1309	transcriptional regulator
CAI14_RS16680	COG1960	acyl-CoA dehydrogenase activity
CAI14_RS16685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAI14_RS16690	COG4770	biotin carboxylase activity
CAI14_RS16730	COG2224	Isocitrate lyase
CAI14_RS16735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CAI14_RS16740	COG0583	DNA-binding transcription factor activity
CAI14_RS16745	COG0475	glutathione-regulated potassium exporter activity
CAI14_RS16775	COG0339	signal peptide processing
CAI14_RS16780	COG1446	asparaginase
CAI14_RS16800	COG0564	pseudouridine synthase activity
CAI14_RS16810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAI14_RS16835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAI14_RS16840	COG0318	PFAM AMP-dependent synthetase and ligase
CAI14_RS16845	COG0727	PFAM Uncharacterised protein family (UPF0153)
CAI14_RS16850	COG0596	Alpha beta hydrolase
CAI14_RS16860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAI14_RS16875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CAI14_RS16900	COG2205	protein histidine kinase activity
CAI14_RS16905	COG0028	Belongs to the TPP enzyme family
CAI14_RS16940	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CAI14_RS16960	COG1157	protein secretion by the type III secretion system
CAI14_RS16975	COG1766	The M ring may be actively involved in energy transduction
CAI14_RS16980	COG1677	Flagellar hook-basal body complex protein FliE
CAI14_RS16995	COG1706	bacterial-type flagellum-dependent cell motility
CAI14_RS17000	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CAI14_RS17010	COG4786	Flagellar basal body rod
CAI14_RS17015	COG4786	Flagellar basal body rod
CAI14_RS17020	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAI14_RS17025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAI14_RS17080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CAI14_RS17085	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CAI14_RS17090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAI14_RS17125	COG0183	Belongs to the thiolase family
CAI14_RS17145	COG2032	superoxide dismutase activity
CAI14_RS17150	COG2032	superoxide dismutase activity
CAI14_RS17155	COG2204	response regulator
CAI14_RS17160	COG3852	Histidine kinase
CAI14_RS17165	COG0004	ammonium transporteR
CAI14_RS17170	COG0347	Belongs to the P(II) protein family
CAI14_RS17175	COG0174	glutamine synthetase
CAI14_RS17180	COG1968	undecaprenyl-diphosphatase activity
CAI14_RS17220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI14_RS17230	COG2062	phosphohistidine phosphatase, SixA
CAI14_RS17235	COG0489	protein tyrosine kinase activity
CAI14_RS17285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAI14_RS17300	COG1125	glycine betaine transport
CAI14_RS17315	COG1119	ATPase activity
CAI14_RS17325	COG1752	Esterase of the alpha-beta hydrolase superfamily
CAI14_RS17335	COG1522	sequence-specific DNA binding
CAI14_RS17340	COG3186	Phenylalanine-4-hydroxylase
CAI14_RS17355	COG2755	lipolytic protein G-D-S-L family
CAI14_RS17365	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS17370	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CAI14_RS17375	COG1609	Transcriptional regulator
CAI14_RS17380	COG3507	Belongs to the glycosyl hydrolase 43 family
CAI14_RS17395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAI14_RS17405	COG0657	acetylesterase activity
CAI14_RS17405	COG2755	lipolytic protein G-D-S-L family
CAI14_RS17425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAI14_RS17430	COG0366	Alpha amylase catalytic
CAI14_RS17435	COG0366	Alpha amylase catalytic
CAI14_RS17515	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CAI14_RS17550	COG2937	Belongs to the GPAT DAPAT family
CAI14_RS17580	COG0284	orotidine-5'-phosphate decarboxylase activity
CAI14_RS17585	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CAI14_RS17590	COG3132	Protein of unknown function, DUF480
CAI14_RS17605	COG0210	DNA helicase
CAI14_RS17620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAI14_RS17650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CAI14_RS17655	COG0739	heme binding
CAI14_RS17660	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CAI14_RS17670	COG2211	Major facilitator Superfamily
CAI14_RS17675	COG0708	Exodeoxyribonuclease III
CAI14_RS17680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CAI14_RS17690	COG1192	Involved in chromosome partitioning
CAI14_RS17695	COG1475	DNA binding
CAI14_RS17710	COG0463	Glycosyl transferase, family 2
CAI14_RS17730	COG0756	dUTP diphosphatase activity
CAI14_RS17735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CAI14_RS17740	COG2003	Belongs to the UPF0758 family
CAI14_RS17745	COG0018	arginyl-trna synthetase
CAI14_RS17760	COG4221	oxidoreductase activity
CAI14_RS17765	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CAI14_RS17765	COG2755	lipolytic protein G-D-S-L family
CAI14_RS17775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAI14_RS17780	COG1166	arginine decarboxylase activity
CAI14_RS17785	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CAI14_RS17825	COG2960	long-chain fatty acid transporting porin activity
CAI14_RS17830	COG0606	chelatase, subunit chli
CAI14_RS17845	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CAI14_RS17875	COG1690	Belongs to the RtcB family
CAI14_RS17910	COG1090	epimerase
CAI14_RS17920	COG0642	Histidine kinase
CAI14_RS17945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAI14_RS17970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAI14_RS17975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CAI14_RS17990	COG0753	catalase activity
CAI14_RS18015	COG2197	response regulator
CAI14_RS18020	COG4585	Histidine kinase
CAI14_RS18025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI14_RS18030	COG1136	(ABC) transporter
CAI14_RS18055	COG0697	spore germination
CAI14_RS18070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAI14_RS18075	COG0180	Tryptophanyl-tRNA synthetase
CAI14_RS18080	COG3237	CsbD-like
CAI14_RS18120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CAI14_RS18180	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CAI14_RS18185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CAI14_RS18185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CAI14_RS18225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CAI14_RS18245	COG1199	ATP-dependent helicase activity
CAI14_RS18260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CAI14_RS18330	COG0625	glutathione transferase activity
CAI14_RS18370	COG4555	ABC transporter
CAI14_RS18380	COG1476	TRANSCRIPTIONal
CAI14_RS18425	COG0543	2 iron, 2 sulfur cluster binding
CAI14_RS18425	COG0633	Ferredoxin
CAI14_RS18430	COG1131	(ABC) transporter
CAI14_RS18435	COG0842	Transport permease protein
CAI14_RS18445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAI14_RS18480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAI14_RS18485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAI14_RS18495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAI14_RS18495	COG1042	CoA-binding domain protein
CAI14_RS18495	COG0045	succinate-CoA ligase (ADP-forming) activity
CAI14_RS18520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CAI14_RS18525	COG3387	PFAM Glycoside hydrolase 15-related
CAI14_RS18540	COG3100	YcgL domain-containing protein
CAI14_RS18545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAI14_RS18565	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS18605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAI14_RS18620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAI14_RS18640	COG0823	Involved in the tonB-independent uptake of proteins
CAI14_RS18640	COG1506	peptidase
CAI14_RS18640	COG4946	Tricorn protease homolog
CAI14_RS18655	COG0408	coproporphyrinogen oxidase activity
CAI14_RS18695	COG0631	protein serine/threonine phosphatase activity
CAI14_RS18885	COG0210	DNA helicase
CAI14_RS18895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI14_RS18900	COG0583	DNA-binding transcription factor activity
CAI14_RS18905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAI14_RS18915	COG2159	amidohydrolase
CAI14_RS18940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI14_RS18960	COG0357	Ribosomal RNA small subunit methyltransferase G
CAI14_RS18965	COG3540	Alkaline phosphatase
CAI14_RS18975	COG2091	lysine biosynthetic process via aminoadipic acid
CAI14_RS18990	COG0708	Exodeoxyribonuclease III
CAI14_RS18995	COG1846	Transcriptional regulator
CAI14_RS18995	COG1940	carbohydrate kinase activity
CAI14_RS19005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAI14_RS19015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CAI14_RS19020	COG3162	membrane
CAI14_RS19030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAI14_RS19065	COG3507	Belongs to the glycosyl hydrolase 43 family
CAI14_RS19085	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS19090	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAI14_RS19095	COG4948	Mandelate Racemase Muconate Lactonizing
CAI14_RS19100	COG3254	rhamnose metabolic process
CAI14_RS19105	COG0738	Major facilitator superfamily
CAI14_RS19110	COG1414	Transcriptional regulator
CAI14_RS19115	COG1971	Probably functions as a manganese efflux pump
CAI14_RS19120	COG2205	protein histidine kinase activity
CAI14_RS19130	COG3459	Glycosyltransferase 36 associated
CAI14_RS19135	COG2211	Major facilitator Superfamily
CAI14_RS19140	COG3265	gluconokinase activity
CAI14_RS19145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAI14_RS19165	COG2911	Protein conserved in bacteria
CAI14_RS19170	COG0729	surface antigen
CAI14_RS19235	COG0752	glycyl-tRNA synthetase alpha subunit
CAI14_RS19250	COG0519	Catalyzes the synthesis of GMP from XMP
CAI14_RS19250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAI14_RS19260	COG0805	protein transport
CAI14_RS19265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAI14_RS19270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAI14_RS19280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CAI14_RS19295	COG2974	May be involved in recombination
CAI14_RS19300	COG0037	tRNA processing
CAI14_RS19305	COG2115	Belongs to the xylose isomerase family
CAI14_RS19325	COG4948	Mandelate Racemase Muconate Lactonizing
CAI14_RS19335	COG1472	Belongs to the glycosyl hydrolase 3 family
CAI14_RS19340	COG0246	Mannitol dehydrogenase
CAI14_RS19430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI14_RS19475	COG3318	Belongs to the UPF0149 family
CAI14_RS19475	COG3012	SEC-C Motif Domain Protein
CAI14_RS19495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI14_RS19510	COG0662	Cupin 2, conserved barrel domain protein
CAI14_RS19530	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CAI14_RS19560	COG0714	Associated with various cellular activities
CAI14_RS19600	COG0477	Major facilitator Superfamily
CAI14_RS19605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAI14_RS19655	COG3237	CsbD-like
CAI14_RS19675	COG2249	NAD(P)H dehydrogenase (quinone) activity
CAI14_RS19695	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS19700	COG0300	oxidoreductase activity
CAI14_RS19720	COG1272	protein, Hemolysin III
CAI14_RS19725	COG1111	helicase
CAI14_RS19725	COG1205	dead DEAH box helicase
CAI14_RS19810	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CAI14_RS19845	COG1132	(ABC) transporter
CAI14_RS19895	COG0438	transferase activity, transferring glycosyl groups
CAI14_RS19895	COG0297	glycogen (starch) synthase activity
CAI14_RS19925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAI14_RS19970	COG0070	glutamate synthase
CAI14_RS19970	COG0069	glutamate synthase activity
CAI14_RS19970	COG0067	glutamate synthase
CAI14_RS19975	COG0493	'glutamate synthase
CAI14_RS19980	COG1064	alcohol dehydrogenase
CAI14_RS19985	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI14_RS19995	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI14_RS20005	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI14_RS20015	COG2234	aminopeptidase activity
CAI14_RS20025	COG4942	peptidase
CAI14_RS20030	COG0793	Belongs to the peptidase S41A family
CAI14_RS20085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI14_RS20095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CAI14_RS20125	COG0501	Belongs to the peptidase M48B family
CAI14_RS20135	COG0187	DNA topoisomerase II activity
CAI14_RS20140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CAI14_RS20150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CAI14_RS20160	COG0594	ribonuclease P activity
CAI14_RS20165	COG0706	membrane insertase activity
CAI14_RS20170	COG0726	polysaccharide deacetylase
CAI14_RS20175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CAI14_RS20190	COG0584	glycerophosphoryl diester phosphodiesterase
CAI14_RS20200	COG0861	Integral membrane protein TerC family
CAI14_RS20205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CAI14_RS20250	COG0531	amino acid
CAI14_RS20260	COG0625	glutathione transferase activity
CAI14_RS20270	COG0583	DNA-binding transcription factor activity
CAI14_RS20275	COG0604	alcohol dehydrogenase
CAI14_RS20280	COG1322	Protein conserved in bacteria
CAI14_RS20290	COG0386	Belongs to the glutathione peroxidase family
CAI14_RS20300	COG2853	Lipoprotein
CAI14_RS20315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAI14_RS20320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAI14_RS20325	COG1127	ABC transporter
CAI14_RS20340	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CAI14_RS20345	COG1074	ATP-dependent DNA helicase activity
CAI14_RS20370	COG3039	Transposase
CAI14_RS20445	COG0564	pseudouridine synthase activity
CAI14_RS20480	COG1309	transcriptional regulator
CAI14_RS20490	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS20515	COG1487	ribonuclease activity
CAI14_RS20520	COG4691	Plasmid stability protein
CAI14_RS20540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI14_RS20550	COG0477	Major facilitator Superfamily
CAI14_RS20555	COG1289	transmembrane transporter activity
CAI14_RS20565	COG1566	PFAM secretion protein HlyD family protein
CAI14_RS20580	COG0302	gtp cyclohydrolase
CAI14_RS20605	COG0730	response to heat
CAI14_RS20610	COG3012	SEC-C Motif Domain Protein
CAI14_RS20620	COG0676	glucose-6-phosphate 1-epimerase activity
CAI14_RS20640	COG3135	benzoate transporter
CAI14_RS20680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAI14_RS20695	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CAI14_RS20725	COG0109	protoheme IX farnesyltransferase activity
CAI14_RS20740	COG0358	DNA primase activity
CAI14_RS20745	COG1295	ribonuclease BN
CAI14_RS20750	COG1610	YqeY-like protein
CAI14_RS20760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CAI14_RS20765	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CAI14_RS20775	COG2133	pyrroloquinoline quinone binding
CAI14_RS20780	COG4682	membrane
CAI14_RS20795	COG0531	amino acid
CAI14_RS20805	COG4948	Mandelate Racemase Muconate Lactonizing
CAI14_RS20815	COG3023	N-Acetylmuramoyl-L-alanine amidase
CAI14_RS20820	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CAI14_RS20860	COG5383	Protein conserved in bacteria
CAI14_RS20870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI14_RS20875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI14_RS20880	COG1473	amidohydrolase
CAI14_RS20885	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CAI14_RS20885	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CAI14_RS20890	COG1652	LysM domain
CAI14_RS20900	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CAI14_RS20905	COG1518	maintenance of DNA repeat elements
CAI14_RS20950	COG0583	DNA-binding transcription factor activity
CAI14_RS20955	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CAI14_RS20960	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CAI14_RS20965	COG3118	belongs to the thioredoxin family
CAI14_RS20970	COG0513	Belongs to the DEAD box helicase family
CAI14_RS20975	COG2884	Cell division ATP-binding protein ftsE
CAI14_RS20980	COG2177	Part of the ABC transporter FtsEX involved in
CAI14_RS20985	COG2201	protein-glutamate methylesterase activity
CAI14_RS20990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CAI14_RS20995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAI14_RS21005	COG1252	NADH dehydrogenase
CAI14_RS21020	COG0625	glutathione transferase activity
CAI14_RS21025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CAI14_RS21045	COG0534	Mate efflux family protein
CAI14_RS21050	COG0616	signal peptide processing
CAI14_RS21060	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS21075	COG0009	L-threonylcarbamoyladenylate synthase
CAI14_RS21080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAI14_RS21080	COG1754	DNA topoisomerase type I activity
CAI14_RS21100	COG0758	DNA mediated transformation
CAI14_RS21105	COG1652	LysM domain
CAI14_RS21110	COG0242	peptide deformylase activity
CAI14_RS21115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CAI14_RS21120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CAI14_RS21120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAI14_RS21170	COG1560	Kdo2-lipid A biosynthetic process
CAI14_RS21175	COG1490	D-aminoacyl-tRNA deacylase activity
CAI14_RS21180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAI14_RS21255	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAI14_RS21260	COG0583	DNA-binding transcription factor activity
CAI14_RS21275	COG0840	transmembrane signaling receptor activity
CAI14_RS21290	COG0251	oxidation-reduction process
CAI14_RS21365	COG1063	alcohol dehydrogenase
CAI14_RS21390	COG1132	(ABC) transporter
CAI14_RS21420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CAI14_RS21425	COG1028	Short-chain dehydrogenase reductase Sdr
CAI14_RS21445	COG1294	oxidase, subunit
CAI14_RS21450	COG1271	oxidase subunit
CAI14_RS21495	COG3546	catalase activity
CAI14_RS21500	COG3685	Protein conserved in bacteria
CAI14_RS21515	COG2972	Histidine kinase
CAI14_RS21530	COG0531	amino acid
CAI14_RS21550	COG3590	peptidase
CAI14_RS21560	COG0667	Aldo Keto reductase
CAI14_RS21580	COG3384	dioxygenase
CAI14_RS21590	COG1573	uracil-dna glycosylase
CAI14_RS21595	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CAI14_RS21600	COG0025	NhaP-type Na H and K H
CAI14_RS21605	COG1131	(ABC) transporter
CAI14_RS21610	COG0842	Transport permease protein
CAI14_RS21665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI14_RS21670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CAI14_RS21690	COG2202	Pas domain
CAI14_RS21690	COG2205	protein histidine kinase activity
CAI14_RS21710	COG2813	Specifically methylates the guanine in position
CAI14_RS21715	COG1187	pseudouridine synthase activity
CAI14_RS21720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAI14_RS21740	COG0784	Response regulator, receiver
CAI14_RS21740	COG2198	Histidine kinase
CAI14_RS21740	COG5002	protein histidine kinase activity
CAI14_RS21750	COG1666	GTP binding
CAI14_RS21755	COG0697	spore germination
CAI14_RS21765	COG2011	ABC-type metal ion transport system permease component
CAI14_RS21810	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAI14_RS21820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAI14_RS21840	COG0356	it plays a direct role in the translocation of protons across the membrane
CAI14_RS21850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CAI14_RS21895	COG1192	Involved in chromosome partitioning
CAI14_RS21985	COG3704	protein secretion by the type IV secretion system
CAI14_RS21995	COG3504	Conjugal transfer protein
CAI14_RS22000	COG2948	multi-organism process
CAI14_RS22185	COG4691	Plasmid stability protein
CAI14_RS22190	COG1487	ribonuclease activity
CAI14_RS22250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CAI14_RS22265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAI14_RS22355	COG1192	Involved in chromosome partitioning
CAI14_RS22470	COG3012	SEC-C Motif Domain Protein
CAI14_RS22470	COG3318	Belongs to the UPF0149 family