locus-tag	class	description
CAI18_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CAI18_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CAI18_RS00020	COG0187	DNA topoisomerase II activity
CAI18_RS00030	COG0501	Belongs to the peptidase M48B family
CAI18_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CAI18_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI18_RS00125	COG0793	Belongs to the peptidase S41A family
CAI18_RS00130	COG4942	peptidase
CAI18_RS00140	COG2234	aminopeptidase activity
CAI18_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI18_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI18_RS00170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI18_RS00175	COG1064	alcohol dehydrogenase
CAI18_RS00180	COG0493	'glutamate synthase
CAI18_RS00185	COG0069	glutamate synthase activity
CAI18_RS00185	COG0070	glutamate synthase
CAI18_RS00185	COG0067	glutamate synthase
CAI18_RS00230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAI18_RS00260	COG0438	transferase activity, transferring glycosyl groups
CAI18_RS00260	COG0297	glycogen (starch) synthase activity
CAI18_RS00310	COG1132	(ABC) transporter
CAI18_RS00340	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CAI18_RS00425	COG1111	helicase
CAI18_RS00425	COG1205	dead DEAH box helicase
CAI18_RS00430	COG1272	protein, Hemolysin III
CAI18_RS00450	COG0300	oxidoreductase activity
CAI18_RS00455	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS00475	COG2249	NAD(P)H dehydrogenase (quinone) activity
CAI18_RS00495	COG3237	CsbD-like
CAI18_RS00545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAI18_RS00550	COG0477	Major facilitator Superfamily
CAI18_RS00590	COG0714	Associated with various cellular activities
CAI18_RS00620	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CAI18_RS00640	COG0662	Cupin 2, conserved barrel domain protein
CAI18_RS00655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI18_RS00675	COG3012	SEC-C Motif Domain Protein
CAI18_RS00675	COG3318	Belongs to the UPF0149 family
CAI18_RS00720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI18_RS00810	COG0246	Mannitol dehydrogenase
CAI18_RS00815	COG1472	Belongs to the glycosyl hydrolase 3 family
CAI18_RS00825	COG4948	Mandelate Racemase Muconate Lactonizing
CAI18_RS00845	COG2115	Belongs to the xylose isomerase family
CAI18_RS00850	COG0037	tRNA processing
CAI18_RS00855	COG2974	May be involved in recombination
CAI18_RS00870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CAI18_RS00880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAI18_RS00885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAI18_RS00890	COG0805	protein transport
CAI18_RS00900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAI18_RS00900	COG0519	Catalyzes the synthesis of GMP from XMP
CAI18_RS00915	COG0752	glycyl-tRNA synthetase alpha subunit
CAI18_RS00980	COG0729	surface antigen
CAI18_RS00985	COG2911	Protein conserved in bacteria
CAI18_RS01005	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAI18_RS01010	COG3265	gluconokinase activity
CAI18_RS01015	COG2211	Major facilitator Superfamily
CAI18_RS01020	COG3459	Glycosyltransferase 36 associated
CAI18_RS01030	COG2205	protein histidine kinase activity
CAI18_RS01035	COG1971	Probably functions as a manganese efflux pump
CAI18_RS01040	COG1414	Transcriptional regulator
CAI18_RS01045	COG0738	Major facilitator superfamily
CAI18_RS01050	COG3254	rhamnose metabolic process
CAI18_RS01055	COG4948	Mandelate Racemase Muconate Lactonizing
CAI18_RS01060	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAI18_RS01065	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS01085	COG3507	Belongs to the glycosyl hydrolase 43 family
CAI18_RS01120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAI18_RS01130	COG3162	membrane
CAI18_RS01135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CAI18_RS01145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAI18_RS01155	COG1846	Transcriptional regulator
CAI18_RS01155	COG1940	carbohydrate kinase activity
CAI18_RS01160	COG0708	Exodeoxyribonuclease III
CAI18_RS01175	COG2091	lysine biosynthetic process via aminoadipic acid
CAI18_RS01185	COG3540	Alkaline phosphatase
CAI18_RS01190	COG0357	Ribosomal RNA small subunit methyltransferase G
CAI18_RS01210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI18_RS01235	COG2159	amidohydrolase
CAI18_RS01245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAI18_RS01250	COG0583	DNA-binding transcription factor activity
CAI18_RS01255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI18_RS01265	COG0210	DNA helicase
CAI18_RS01420	COG3501	Rhs element vgr protein
CAI18_RS01455	COG0631	protein serine/threonine phosphatase activity
CAI18_RS01460	COG0515	serine threonine protein kinase
CAI18_RS01495	COG0408	coproporphyrinogen oxidase activity
CAI18_RS01510	COG0823	Involved in the tonB-independent uptake of proteins
CAI18_RS01510	COG1506	peptidase
CAI18_RS01510	COG4946	Tricorn protease homolog
CAI18_RS01530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAI18_RS01545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAI18_RS01585	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS01595	COG0463	Glycosyl transferase, family 2
CAI18_RS01605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAI18_RS01610	COG3100	YcgL domain-containing protein
CAI18_RS01625	COG3387	PFAM Glycoside hydrolase 15-related
CAI18_RS01630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CAI18_RS01650	COG2239	Acts as a magnesium transporter
CAI18_RS01655	COG0045	succinate-CoA ligase (ADP-forming) activity
CAI18_RS01655	COG1042	CoA-binding domain protein
CAI18_RS01655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAI18_RS01665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAI18_RS01670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAI18_RS01705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAI18_RS01715	COG0842	Transport permease protein
CAI18_RS01720	COG1131	(ABC) transporter
CAI18_RS01725	COG0633	Ferredoxin
CAI18_RS01725	COG0543	2 iron, 2 sulfur cluster binding
CAI18_RS01770	COG1476	TRANSCRIPTIONal
CAI18_RS01780	COG4555	ABC transporter
CAI18_RS01820	COG0625	glutathione transferase activity
CAI18_RS01890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CAI18_RS01905	COG1199	ATP-dependent helicase activity
CAI18_RS01925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CAI18_RS01935	COG0745	RESPONSE REGULATOR receiver
CAI18_RS01940	COG2205	protein histidine kinase activity
CAI18_RS01965	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CAI18_RS01965	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CAI18_RS01970	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CAI18_RS02030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CAI18_RS02070	COG3237	CsbD-like
CAI18_RS02075	COG0180	Tryptophanyl-tRNA synthetase
CAI18_RS02080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAI18_RS02095	COG0697	spore germination
CAI18_RS02120	COG1136	(ABC) transporter
CAI18_RS02125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI18_RS02130	COG4585	Histidine kinase
CAI18_RS02135	COG2197	response regulator
CAI18_RS02160	COG0753	catalase activity
CAI18_RS02175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CAI18_RS02180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAI18_RS02205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAI18_RS02230	COG0642	Histidine kinase
CAI18_RS02235	COG0745	RESPONSE REGULATOR receiver
CAI18_RS02240	COG1090	epimerase
CAI18_RS02275	COG1690	Belongs to the RtcB family
CAI18_RS02305	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CAI18_RS02320	COG0606	chelatase, subunit chli
CAI18_RS02325	COG2960	long-chain fatty acid transporting porin activity
CAI18_RS02365	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CAI18_RS02370	COG1166	arginine decarboxylase activity
CAI18_RS02375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAI18_RS02385	COG2755	lipolytic protein G-D-S-L family
CAI18_RS02385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CAI18_RS02390	COG4221	oxidoreductase activity
CAI18_RS02405	COG0018	arginyl-trna synthetase
CAI18_RS02410	COG2003	Belongs to the UPF0758 family
CAI18_RS02415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CAI18_RS02420	COG0756	dUTP diphosphatase activity
CAI18_RS02440	COG0463	Glycosyl transferase, family 2
CAI18_RS02455	COG1475	DNA binding
CAI18_RS02460	COG1192	Involved in chromosome partitioning
CAI18_RS02470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CAI18_RS02475	COG0708	Exodeoxyribonuclease III
CAI18_RS02480	COG2211	Major facilitator Superfamily
CAI18_RS02490	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CAI18_RS02495	COG0739	heme binding
CAI18_RS02500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CAI18_RS02530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAI18_RS02545	COG0210	DNA helicase
CAI18_RS02560	COG3132	Protein of unknown function, DUF480
CAI18_RS02565	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CAI18_RS02570	COG0284	orotidine-5'-phosphate decarboxylase activity
CAI18_RS02600	COG2937	Belongs to the GPAT DAPAT family
CAI18_RS02635	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CAI18_RS02715	COG0366	Alpha amylase catalytic
CAI18_RS02720	COG0366	Alpha amylase catalytic
CAI18_RS02725	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAI18_RS02745	COG2755	lipolytic protein G-D-S-L family
CAI18_RS02745	COG0657	acetylesterase activity
CAI18_RS02755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAI18_RS02770	COG3507	Belongs to the glycosyl hydrolase 43 family
CAI18_RS02775	COG1609	Transcriptional regulator
CAI18_RS02780	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CAI18_RS02785	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS02795	COG2755	lipolytic protein G-D-S-L family
CAI18_RS02810	COG3186	Phenylalanine-4-hydroxylase
CAI18_RS02815	COG1522	sequence-specific DNA binding
CAI18_RS02825	COG1752	Esterase of the alpha-beta hydrolase superfamily
CAI18_RS02835	COG1119	ATPase activity
CAI18_RS02850	COG1125	glycine betaine transport
CAI18_RS02865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAI18_RS02915	COG0489	protein tyrosine kinase activity
CAI18_RS02920	COG2062	phosphohistidine phosphatase, SixA
CAI18_RS02930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI18_RS02970	COG1968	undecaprenyl-diphosphatase activity
CAI18_RS02975	COG0174	glutamine synthetase
CAI18_RS02980	COG0347	Belongs to the P(II) protein family
CAI18_RS02985	COG0004	ammonium transporteR
CAI18_RS02990	COG3852	Histidine kinase
CAI18_RS02995	COG2204	response regulator
CAI18_RS03000	COG2032	superoxide dismutase activity
CAI18_RS03005	COG2032	superoxide dismutase activity
CAI18_RS03025	COG0183	Belongs to the thiolase family
CAI18_RS03060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAI18_RS03065	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CAI18_RS03070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CAI18_RS03125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAI18_RS03130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAI18_RS03135	COG4786	Flagellar basal body rod
CAI18_RS03140	COG4786	Flagellar basal body rod
CAI18_RS03155	COG1706	bacterial-type flagellum-dependent cell motility
CAI18_RS03170	COG1677	Flagellar hook-basal body complex protein FliE
CAI18_RS03175	COG1766	The M ring may be actively involved in energy transduction
CAI18_RS03190	COG1157	protein secretion by the type III secretion system
CAI18_RS03210	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CAI18_RS03245	COG0028	Belongs to the TPP enzyme family
CAI18_RS03250	COG2205	protein histidine kinase activity
CAI18_RS03275	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CAI18_RS03290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAI18_RS03300	COG0596	Alpha beta hydrolase
CAI18_RS03305	COG0727	PFAM Uncharacterised protein family (UPF0153)
CAI18_RS03310	COG0318	PFAM AMP-dependent synthetase and ligase
CAI18_RS03315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAI18_RS03340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAI18_RS03350	COG0564	pseudouridine synthase activity
CAI18_RS03370	COG1446	asparaginase
CAI18_RS03375	COG0339	signal peptide processing
CAI18_RS03405	COG0475	glutathione-regulated potassium exporter activity
CAI18_RS03410	COG0583	DNA-binding transcription factor activity
CAI18_RS03415	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CAI18_RS03420	COG2224	Isocitrate lyase
CAI18_RS03425	COG3706	GGDEF domain
CAI18_RS03460	COG4770	biotin carboxylase activity
CAI18_RS03465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAI18_RS03470	COG1960	acyl-CoA dehydrogenase activity
CAI18_RS03475	COG1309	transcriptional regulator
CAI18_RS03530	COG0523	cobalamin synthesis protein
CAI18_RS03550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CAI18_RS03555	COG1846	Transcriptional regulator
CAI18_RS03560	COG1764	response to oxidative stress
CAI18_RS03585	COG2130	NADP-dependent
CAI18_RS03600	COG1187	pseudouridine synthase activity
CAI18_RS03615	COG1643	Atp-dependent helicase
CAI18_RS03620	COG4807	Protein conserved in bacteria
CAI18_RS03625	COG2351	hydroxyisourate hydrolase activity
CAI18_RS03630	COG2072	flavoprotein involved in K transport
CAI18_RS03650	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CAI18_RS03685	COG1957	nucleoside hydrolase
CAI18_RS03695	COG2252	PERMEase
CAI18_RS03715	COG0084	hydrolase, TatD family'
CAI18_RS03735	COG0583	DNA-binding transcription factor activity
CAI18_RS03740	COG2814	Major facilitator Superfamily
CAI18_RS03755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CAI18_RS03760	COG1902	pentaerythritol trinitrate reductase activity
CAI18_RS03780	COG0745	RESPONSE REGULATOR receiver
CAI18_RS03785	COG2205	protein histidine kinase activity
CAI18_RS03790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI18_RS03815	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CAI18_RS03820	COG0583	DNA-binding transcription factor activity
CAI18_RS03850	COG0702	epimerase
CAI18_RS03855	COG1733	regulation of RNA biosynthetic process
CAI18_RS03900	COG0129	dihydroxy-acid dehydratase activity
CAI18_RS03915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CAI18_RS03970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CAI18_RS03975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CAI18_RS04000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CAI18_RS04005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CAI18_RS04015	COG3485	protocatechuate 3,4-dioxygenase
CAI18_RS04030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAI18_RS04035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAI18_RS04045	COG1414	Transcriptional regulator
CAI18_RS04065	COG0445	tRNA wobble uridine modification
CAI18_RS04105	COG2267	carboxylic ester hydrolase activity
CAI18_RS04115	COG0156	8-amino-7-oxononanoate synthase activity
CAI18_RS04120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CAI18_RS04125	COG1040	competence protein
CAI18_RS04130	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CAI18_RS04215	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAI18_RS04285	COG3264	Mechanosensitive ion channel
CAI18_RS04285	COG1511	domain protein
CAI18_RS04290	COG1368	sulfuric ester hydrolase activity
CAI18_RS04295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAI18_RS04300	COG2354	Protein conserved in bacteria
CAI18_RS04310	COG0297	glycogen (starch) synthase activity
CAI18_RS04315	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAI18_RS04320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAI18_RS04345	COG0702	epimerase
CAI18_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS04385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI18_RS04390	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS04400	COG0513	Belongs to the DEAD box helicase family
CAI18_RS04425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CAI18_RS04435	COG3483	tryptophan 2,3-dioxygenase activity
CAI18_RS04440	COG3104	oligopeptide transport
CAI18_RS04465	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CAI18_RS04480	COG1320	monovalent cation:proton antiporter activity
CAI18_RS04485	COG2212	antiporter activity
CAI18_RS04495	COG0651	ATP synthesis coupled electron transport
CAI18_RS04500	COG1006	Multisubunit Na H antiporter MnhC subunit
CAI18_RS04505	COG2111	Na H antiporter
CAI18_RS04505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAI18_RS04525	COG3179	chitinase
CAI18_RS04545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CAI18_RS04550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CAI18_RS04565	COG0456	acetyltransferase
CAI18_RS04570	COG1597	lipid kinase activity
CAI18_RS04595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CAI18_RS04600	COG0134	indole-3-glycerol-phosphate synthase activity
CAI18_RS04610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAI18_RS04615	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CAI18_RS04625	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CAI18_RS04635	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CAI18_RS04650	COG1051	belongs to the nudix hydrolase family
CAI18_RS04690	COG0316	Belongs to the HesB IscA family
CAI18_RS04705	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CAI18_RS04720	COG2814	Major facilitator Superfamily
CAI18_RS04730	COG2814	Major facilitator Superfamily
CAI18_RS04735	COG1289	transmembrane transporter activity
CAI18_RS04745	COG0151	Belongs to the GarS family
CAI18_RS04755	COG0138	bifunctional purine biosynthesis protein purh
CAI18_RS04760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAI18_RS04765	COG2267	carboxylic ester hydrolase activity
CAI18_RS04770	COG2453	phosphatase
CAI18_RS04770	COG0671	phosphoesterase, PA-phosphatase related
CAI18_RS04795	COG4589	Belongs to the CDS family
CAI18_RS04800	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CAI18_RS04820	COG2264	protein methyltransferase activity
CAI18_RS04835	COG0439	Biotin carboxylase
CAI18_RS04845	COG0511	ligase activity, forming carbon-carbon bonds
CAI18_RS04850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CAI18_RS04860	COG1324	tolerance protein
CAI18_RS04885	COG0300	oxidoreductase activity
CAI18_RS04895	COG2356	endonuclease I
CAI18_RS04905	COG0459	protein refolding
CAI18_RS04920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CAI18_RS04935	COG3386	PFAM SMP-30 Gluconolaconase
CAI18_RS04945	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CAI18_RS04950	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CAI18_RS04965	COG0778	Nitroreductase
CAI18_RS04970	COG2353	YceI-like domain
CAI18_RS05000	COG3052	prosthetic group binding
CAI18_RS05035	COG1802	Transcriptional regulator
CAI18_RS05110	COG4221	oxidoreductase activity
CAI18_RS05125	COG4221	oxidoreductase activity
CAI18_RS05135	COG0435	Glutathione S-transferase
CAI18_RS05160	COG2409	Drug exporters of the RND superfamily
CAI18_RS05170	COG1506	peptidase
CAI18_RS05170	COG0823	Involved in the tonB-independent uptake of proteins
CAI18_RS05180	COG3706	GGDEF domain
CAI18_RS05205	COG0697	spore germination
CAI18_RS05220	COG1113	amino acid transport
CAI18_RS05240	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CAI18_RS05285	COG5001	Diguanylate cyclase
CAI18_RS05295	COG0840	transmembrane signaling receptor activity
CAI18_RS05300	COG5297	Belongs to the glycosyl hydrolase family 6
CAI18_RS05300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI18_RS05305	COG0659	secondary active sulfate transmembrane transporter activity
CAI18_RS05310	COG3706	GGDEF domain
CAI18_RS05320	COG2943	transferase activity, transferring hexosyl groups
CAI18_RS05330	COG3275	phosphorelay sensor kinase activity
CAI18_RS05340	COG0181	hydroxymethylbilane synthase activity
CAI18_RS05375	COG1505	serine-type exopeptidase activity
CAI18_RS05395	COG2832	Protein of unknown function (DUF454)
CAI18_RS05405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CAI18_RS05415	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CAI18_RS05420	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CAI18_RS05425	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CAI18_RS05450	COG2226	methyltransferase
CAI18_RS05455	COG5001	Diguanylate cyclase
CAI18_RS05455	COG3300	MHYT domain
CAI18_RS05460	COG0308	aminopeptidase N
CAI18_RS05490	COG1162	GTPase activity
CAI18_RS05520	COG1609	Transcriptional regulator
CAI18_RS05525	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS05530	COG2851	Citrate transporter
CAI18_RS05545	COG0642	Histidine kinase
CAI18_RS05555	COG2197	response regulator
CAI18_RS05575	COG0667	Aldo Keto reductase
CAI18_RS05580	COG0583	DNA-binding transcription factor activity
CAI18_RS05610	COG1301	dicarboxylic acid transport
CAI18_RS05615	COG0281	malic enzyme
CAI18_RS05615	COG0280	phosphate acetyltransferase
CAI18_RS05640	COG1560	Kdo2-lipid A biosynthetic process
CAI18_RS05645	COG1519	Transferase
CAI18_RS05650	COG1538	Outer membrane efflux protein
CAI18_RS05655	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAI18_RS05675	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAI18_RS05680	COG0066	3-isopropylmalate dehydratase activity
CAI18_RS05685	COG0473	3-isopropylmalate dehydrogenase activity
CAI18_RS05690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAI18_RS05710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CAI18_RS05720	COG0840	transmembrane signaling receptor activity
CAI18_RS05730	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CAI18_RS05735	COG3710	Transcriptional regulator
CAI18_RS05765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CAI18_RS05775	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CAI18_RS05800	COG0563	adenylate kinase activity
CAI18_RS05815	COG3781	membrane
CAI18_RS05820	COG0671	phosphoesterase, PA-phosphatase related
CAI18_RS05830	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS05840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAI18_RS05845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAI18_RS05875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAI18_RS05890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CAI18_RS05900	COG0352	thiamine-phosphate diphosphorylase activity
CAI18_RS05905	COG1773	rubredoxin
CAI18_RS05910	COG2912	Transglutaminase-like superfamily
CAI18_RS05920	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CAI18_RS05930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CAI18_RS05950	COG3079	Belongs to the UPF0149 family
CAI18_RS05955	COG0006	proline dipeptidase activity
CAI18_RS05965	COG0006	proline dipeptidase activity
CAI18_RS05980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CAI18_RS05985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CAI18_RS05995	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CAI18_RS06000	COG1561	YicC-like family, N-terminal region
CAI18_RS06005	COG0194	GDP metabolic process
CAI18_RS06015	COG1070	Carbohydrate kinase
CAI18_RS06020	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS06040	COG3659	wide pore channel activity
CAI18_RS06055	COG2390	Transcriptional regulator
CAI18_RS06060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAI18_RS06065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAI18_RS06075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CAI18_RS06105	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CAI18_RS06135	COG0714	Associated with various cellular activities
CAI18_RS06155	COG2304	oxidoreductase activity
CAI18_RS06165	COG1301	dicarboxylic acid transport
CAI18_RS06170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CAI18_RS06175	COG0596	Alpha beta hydrolase
CAI18_RS06180	COG4773	Receptor
CAI18_RS06190	COG0739	heme binding
CAI18_RS06200	COG1376	ErfK ybiS ycfS ynhG family protein
CAI18_RS06235	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CAI18_RS06240	COG4149	molybdate abc transporter
CAI18_RS06245	COG0725	ABC transporter, periplasmic molybdate-binding protein
CAI18_RS06250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAI18_RS06250	COG3453	Protein conserved in bacteria
CAI18_RS06260	COG3047	cAMP biosynthetic process
CAI18_RS06265	COG3047	cAMP biosynthetic process
CAI18_RS06280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CAI18_RS06300	COG0126	phosphoglycerate kinase activity
CAI18_RS06310	COG0469	pyruvate kinase activity
CAI18_RS06315	COG3588	fructose-bisphosphate aldolase
CAI18_RS06320	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CAI18_RS06335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAI18_RS06335	COG1648	precorrin-2 dehydrogenase activity
CAI18_RS06350	COG2205	protein histidine kinase activity
CAI18_RS06350	COG2198	Histidine kinase
CAI18_RS06350	COG0784	Response regulator, receiver
CAI18_RS06370	COG0175	sulfate reduction
CAI18_RS06375	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAI18_RS06380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CAI18_RS06385	COG0175	sulfate reduction
CAI18_RS06390	COG2895	sulfate adenylyltransferase (ATP) activity
CAI18_RS06390	COG0529	Catalyzes the synthesis of activated sulfate
CAI18_RS06395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI18_RS06400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI18_RS06450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAI18_RS06465	COG4948	Mandelate Racemase Muconate Lactonizing
CAI18_RS06470	COG3250	beta-galactosidase activity
CAI18_RS06480	COG1609	Transcriptional regulator
CAI18_RS06490	COG1970	mechanosensitive ion channel activity
CAI18_RS06510	COG0471	metal ion transport
CAI18_RS06510	COG3273	potassium ion transport
CAI18_RS06515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CAI18_RS06520	COG2022	thiamine diphosphate biosynthetic process
CAI18_RS06565	COG0189	ligase activity
CAI18_RS06575	COG0745	RESPONSE REGULATOR receiver
CAI18_RS06580	COG5002	protein histidine kinase activity
CAI18_RS06675	COG2010	Cytochrome c
CAI18_RS06695	COG3284	Transcriptional regulator
CAI18_RS06700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAI18_RS06705	COG1077	Cell shape determining protein MreB Mrl
CAI18_RS06710	COG1792	Involved in formation and maintenance of cell shape
CAI18_RS06725	COG0772	Belongs to the SEDS family
CAI18_RS06735	COG2951	lytic endotransglycosylase activity
CAI18_RS06740	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CAI18_RS06745	COG1686	Belongs to the peptidase S11 family
CAI18_RS06755	COG2921	Belongs to the UPF0250 family
CAI18_RS06760	COG0321	lipoyl(octanoyl) transferase activity
CAI18_RS06765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CAI18_RS06780	COG0583	DNA-binding transcription factor activity
CAI18_RS06790	COG1051	belongs to the nudix hydrolase family
CAI18_RS06790	COG1056	cytidyltransferase-related domain
CAI18_RS06825	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CAI18_RS06830	COG0673	inositol 2-dehydrogenase activity
CAI18_RS06835	COG2823	Periplasmic or secreted lipoprotein
CAI18_RS06840	COG4251	negative regulation of phosphorylation
CAI18_RS06845	COG0784	Response regulator, receiver
CAI18_RS06850	COG4191	Histidine kinase
CAI18_RS06855	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CAI18_RS06910	COG1459	type II secretion system
CAI18_RS06930	COG4795	General secretion pathway protein
CAI18_RS06960	COG3250	beta-galactosidase activity
CAI18_RS06975	COG2188	Transcriptional regulator
CAI18_RS06985	COG1609	Transcriptional regulator
CAI18_RS06990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAI18_RS06995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CAI18_RS07005	COG0617	tRNA 3'-terminal CCA addition
CAI18_RS07010	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CAI18_RS07015	COG1012	belongs to the aldehyde dehydrogenase family
CAI18_RS07020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CAI18_RS07050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CAI18_RS07055	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CAI18_RS07070	COG2205	protein histidine kinase activity
CAI18_RS07075	COG0745	RESPONSE REGULATOR receiver
CAI18_RS07100	COG3791	Glutathione-dependent formaldehyde-activating
CAI18_RS07115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAI18_RS07125	COG0697	spore germination
CAI18_RS07135	COG0488	(ABC) transporter
CAI18_RS07145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CAI18_RS07150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CAI18_RS07160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAI18_RS07160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAI18_RS07180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CAI18_RS07185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAI18_RS07190	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CAI18_RS07210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CAI18_RS07215	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CAI18_RS07220	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CAI18_RS07225	COG2205	protein histidine kinase activity
CAI18_RS07230	COG0745	RESPONSE REGULATOR receiver
CAI18_RS07265	COG0277	FAD linked oxidase domain protein
CAI18_RS07270	COG1988	membrane-bound metal-dependent
CAI18_RS07275	COG0792	nuclease activity
CAI18_RS07315	COG0275	rRNA processing
CAI18_RS07320	COG3116	cell division
CAI18_RS07330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CAI18_RS07335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CAI18_RS07340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAI18_RS07350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CAI18_RS07355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CAI18_RS07360	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAI18_RS07365	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CAI18_RS07380	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CAI18_RS07395	COG0653	protein targeting
CAI18_RS07400	COG0494	nUDIX hydrolase
CAI18_RS07410	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CAI18_RS07420	COG0604	alcohol dehydrogenase
CAI18_RS07420	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS07420	COG3321	synthase
CAI18_RS07445	COG0366	Alpha amylase catalytic
CAI18_RS07475	COG2226	methyltransferase
CAI18_RS07480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CAI18_RS07490	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CAI18_RS07540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CAI18_RS07550	COG4106	trans-aconitate 2-methyltransferase activity
CAI18_RS07555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CAI18_RS07565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAI18_RS07570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CAI18_RS07575	COG0667	Aldo Keto reductase
CAI18_RS07585	COG4771	TonB-dependent receptor
CAI18_RS07605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAI18_RS07610	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CAI18_RS07620	COG2175	clavaminate synthase activity
CAI18_RS07630	COG4181	ATPase activity
CAI18_RS07645	COG0642	Histidine kinase
CAI18_RS07665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CAI18_RS07680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI18_RS07685	COG2201	protein-glutamate methylesterase activity
CAI18_RS07690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CAI18_RS07695	COG2200	EAL domain
CAI18_RS07695	COG2199	diguanylate cyclase activity
CAI18_RS07695	COG2202	Pas domain
CAI18_RS07700	COG0835	chemotaxis
CAI18_RS07705	COG0840	transmembrane signaling receptor activity
CAI18_RS07710	COG2198	Histidine kinase
CAI18_RS07710	COG0643	Histidine kinase
CAI18_RS07725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CAI18_RS07735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CAI18_RS07745	COG2205	protein histidine kinase activity
CAI18_RS07750	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CAI18_RS07760	COG4452	Inner membrane protein CreD
CAI18_RS07785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAI18_RS07790	COG0735	belongs to the Fur family
CAI18_RS07805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI18_RS07835	COG0583	DNA-binding transcription factor activity
CAI18_RS07840	COG2814	Major facilitator Superfamily
CAI18_RS07975	COG5001	Diguanylate cyclase
CAI18_RS07975	COG5002	protein histidine kinase activity
CAI18_RS07980	COG1187	pseudouridine synthase activity
CAI18_RS08000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAI18_RS08010	COG0475	glutathione-regulated potassium exporter activity
CAI18_RS08015	COG5000	phosphorelay sensor kinase activity
CAI18_RS08015	COG5002	protein histidine kinase activity
CAI18_RS08020	COG0745	RESPONSE REGULATOR receiver
CAI18_RS08025	COG1538	Outer membrane efflux protein
CAI18_RS08055	COG1132	(ABC) transporter
CAI18_RS08100	COG2155	Conserved Protein
CAI18_RS08130	COG3118	belongs to the thioredoxin family
CAI18_RS08140	COG0495	leucyl-tRNA aminoacylation
CAI18_RS08155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CAI18_RS08170	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CAI18_RS08190	COG2968	Membrane
CAI18_RS08195	COG0424	maF-like protein
CAI18_RS08200	COG1530	ribonuclease E activity
CAI18_RS08205	COG3164	Protein of unknown function
CAI18_RS08215	COG0312	modulator of DNA gyrase
CAI18_RS08220	COG3028	Belongs to the UPF0307 family
CAI18_RS08225	COG0312	modulator of DNA gyrase
CAI18_RS08240	COG3318	Belongs to the UPF0149 family
CAI18_RS08240	COG3012	SEC-C Motif Domain Protein
CAI18_RS08260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI18_RS08270	COG0142	geranyltranstransferase activity
CAI18_RS08275	COG1722	exodeoxyribonuclease VII activity
CAI18_RS08280	COG0037	tRNA processing
CAI18_RS08285	COG1785	Belongs to the alkaline phosphatase family
CAI18_RS08290	COG1301	dicarboxylic acid transport
CAI18_RS08295	COG4106	trans-aconitate 2-methyltransferase activity
CAI18_RS08305	COG0791	NLP P60 protein
CAI18_RS08310	COG0791	NLP P60 protein
CAI18_RS08315	COG1047	Peptidyl-prolyl cis-trans
CAI18_RS08320	COG2311	Membrane
CAI18_RS08325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI18_RS08330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAI18_RS08355	COG3590	peptidase
CAI18_RS08360	COG3590	peptidase
CAI18_RS08425	COG3209	COG3209 Rhs family protein
CAI18_RS08475	COG3250	beta-galactosidase activity
CAI18_RS08480	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CAI18_RS08500	COG1960	acyl-CoA dehydrogenase activity
CAI18_RS08505	COG1024	Enoyl-CoA hydratase
CAI18_RS08540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAI18_RS08545	COG0481	GTPase activity
CAI18_RS08560	COG0571	ribonuclease III activity
CAI18_RS08565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CAI18_RS08580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAI18_RS08590	COG2954	triphosphatase activity
CAI18_RS08595	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CAI18_RS08600	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CAI18_RS08605	COG3046	protein related to deoxyribodipyrimidine photolyase
CAI18_RS08610	COG1472	Belongs to the glycosyl hydrolase 3 family
CAI18_RS08620	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CAI18_RS08630	COG1278	Cold shock
CAI18_RS08645	COG1201	RNA secondary structure unwinding
CAI18_RS08650	COG1793	dna ligase
CAI18_RS08660	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CAI18_RS08660	COG1793	dna ligase
CAI18_RS08690	COG0183	Belongs to the thiolase family
CAI18_RS08715	COG1451	nucleotide metabolic process
CAI18_RS08720	COG5487	UPF0391 membrane protein
CAI18_RS08730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CAI18_RS08750	COG1047	Peptidyl-prolyl cis-trans
CAI18_RS08760	COG2824	Alkylphosphonate utilization operon protein PhnA
CAI18_RS08770	COG2814	Major facilitator Superfamily
CAI18_RS08805	COG0392	lysyltransferase activity
CAI18_RS08805	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CAI18_RS08815	COG0251	oxidation-reduction process
CAI18_RS08820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAI18_RS08835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAI18_RS08860	COG1595	DNA-templated transcription, initiation
CAI18_RS08875	COG2878	Part of a membrane complex involved in electron transport
CAI18_RS08885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAI18_RS08885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAI18_RS08900	COG1131	(ABC) transporter
CAI18_RS08905	COG0346	lactoylglutathione lyase activity
CAI18_RS08910	COG0833	amino acid
CAI18_RS08915	COG2040	homocysteine
CAI18_RS08925	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CAI18_RS08945	COG1695	Transcriptional regulator
CAI18_RS08980	COG0825	malonyl-CoA metabolic process
CAI18_RS08990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CAI18_RS08995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAI18_RS09000	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAI18_RS09005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAI18_RS09010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAI18_RS09025	COG0750	zinc metalloprotease
CAI18_RS09030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CAI18_RS09035	COG0575	Belongs to the CDS family
CAI18_RS09040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAI18_RS09045	COG0233	cytoplasmic translational termination
CAI18_RS09050	COG0528	UMP kinase activity
CAI18_RS09060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CAI18_RS09065	COG0052	Belongs to the universal ribosomal protein uS2 family
CAI18_RS09115	COG1393	Belongs to the ArsC family
CAI18_RS09120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAI18_RS09125	COG0367	asparagine synthase
CAI18_RS09135	COG4774	siderophore transport
CAI18_RS09175	COG1566	PFAM secretion protein HlyD family protein
CAI18_RS09180	COG2814	Major facilitator Superfamily
CAI18_RS09205	COG3104	oligopeptide transport
CAI18_RS09235	COG0339	signal peptide processing
CAI18_RS09240	COG0386	Belongs to the glutathione peroxidase family
CAI18_RS09300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CAI18_RS09305	COG0084	hydrolase, TatD family'
CAI18_RS09320	COG1960	acyl-CoA dehydrogenase activity
CAI18_RS09340	COG0367	asparagine synthase
CAI18_RS09350	COG0305	Participates in initiation and elongation during chromosome replication
CAI18_RS09355	COG0415	Belongs to the DNA photolyase family
CAI18_RS09365	COG0583	DNA-binding transcription factor activity
CAI18_RS09400	COG3706	GGDEF domain
CAI18_RS09410	COG3706	GGDEF domain
CAI18_RS09435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CAI18_RS09450	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAI18_RS09460	COG0497	DNA recombination
CAI18_RS09465	COG1420	regulation of RNA biosynthetic process
CAI18_RS09470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CAI18_RS09475	COG0443	Heat shock 70 kDa protein
CAI18_RS09480	COG0484	heat shock protein binding
CAI18_RS09515	COG0583	DNA-binding transcription factor activity
CAI18_RS09520	COG1132	(ABC) transporter
CAI18_RS09555	COG2850	peptidyl-arginine hydroxylation
CAI18_RS09575	COG1253	flavin adenine dinucleotide binding
CAI18_RS09605	COG1131	(ABC) transporter
CAI18_RS09610	COG1725	Transcriptional regulator
CAI18_RS09620	COG0386	Belongs to the glutathione peroxidase family
CAI18_RS09635	COG2900	Belongs to the SlyX family
CAI18_RS09660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAI18_RS09685	COG1410	methionine synthase
CAI18_RS09685	COG0646	methionine synthase
CAI18_RS09690	COG2226	methyltransferase
CAI18_RS09695	COG1960	acyl-CoA dehydrogenase activity
CAI18_RS09700	COG1960	acyl-CoA dehydrogenase activity
CAI18_RS09715	COG0557	exoribonuclease II activity
CAI18_RS09725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAI18_RS09730	COG3706	GGDEF domain
CAI18_RS09735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAI18_RS09745	COG0704	Plays a role in the regulation of phosphate uptake
CAI18_RS09750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAI18_RS09755	COG0581	inorganic phosphate transmembrane transporter activity
CAI18_RS09760	COG0573	inorganic phosphate transmembrane transporter activity
CAI18_RS09765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CAI18_RS09790	COG0659	secondary active sulfate transmembrane transporter activity
CAI18_RS09795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CAI18_RS09805	COG1024	Enoyl-CoA hydratase
CAI18_RS09815	COG0494	nUDIX hydrolase
CAI18_RS09860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CAI18_RS09860	COG0116	Belongs to the methyltransferase superfamily
CAI18_RS09865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CAI18_RS09890	COG2925	Exonuclease
CAI18_RS09900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAI18_RS09905	COG3844	kynureninase activity
CAI18_RS09915	COG0662	Cupin 2, conserved barrel domain protein
CAI18_RS09920	COG0288	reversible hydration of carbon dioxide
CAI18_RS09985	COG2808	Putative FMN-binding domain
CAI18_RS10005	COG0017	Asparaginyl-tRNA synthetase
CAI18_RS10010	COG0316	Belongs to the HesB IscA family
CAI18_RS10015	COG0360	Binds together with S18 to 16S ribosomal RNA
CAI18_RS10020	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CAI18_RS10025	COG0359	binds to the 23S rRNA
CAI18_RS10035	COG3115	cell septum assembly
CAI18_RS10045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAI18_RS10050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CAI18_RS10055	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CAI18_RS10065	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CAI18_RS10075	COG4993	Dehydrogenase
CAI18_RS10085	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CAI18_RS10095	COG2986	histidine ammonia-lyase
CAI18_RS10100	COG1228	amidohydrolase
CAI18_RS10140	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CAI18_RS10145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAI18_RS10150	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CAI18_RS10155	COG1605	Chorismate mutase
CAI18_RS10155	COG0077	Prephenate dehydratase
CAI18_RS10160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CAI18_RS10175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CAI18_RS10180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAI18_RS10185	COG0583	DNA-binding transcription factor activity
CAI18_RS10215	COG0840	transmembrane signaling receptor activity
CAI18_RS10240	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CAI18_RS10245	COG4191	Histidine kinase
CAI18_RS10245	COG0784	Response regulator, receiver
CAI18_RS10260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAI18_RS10270	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CAI18_RS10280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAI18_RS10295	COG1595	DNA-templated transcription, initiation
CAI18_RS10345	COG2244	polysaccharide biosynthetic process
CAI18_RS10375	COG2264	protein methyltransferase activity
CAI18_RS10400	COG1136	(ABC) transporter
CAI18_RS10405	COG1132	(ABC) transporter
CAI18_RS10410	COG0477	Major facilitator Superfamily
CAI18_RS10415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAI18_RS10430	COG1253	flavin adenine dinucleotide binding
CAI18_RS10440	COG0306	phosphate transporter
CAI18_RS10465	COG0504	CTP synthase activity
CAI18_RS10470	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CAI18_RS10480	COG0148	phosphopyruvate hydratase activity
CAI18_RS10485	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CAI18_RS10490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CAI18_RS10495	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CAI18_RS10500	COG0585	pseudouridine synthase activity
CAI18_RS10505	COG2840	Smr protein MutS2
CAI18_RS10510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CAI18_RS10515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAI18_RS10520	COG1238	metal cluster binding
CAI18_RS10535	COG1534	Rna-binding protein
CAI18_RS10540	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CAI18_RS10550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CAI18_RS10555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CAI18_RS10565	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CAI18_RS10570	COG1546	Belongs to the CinA family
CAI18_RS10580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CAI18_RS10585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CAI18_RS10590	COG2137	regulation of response to DNA damage stimulus
CAI18_RS10595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CAI18_RS10600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CAI18_RS10615	COG1741	Belongs to the pirin family
CAI18_RS10620	COG0583	DNA-binding transcription factor activity
CAI18_RS10645	COG0351	phosphomethylpyrimidine kinase
CAI18_RS10660	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CAI18_RS10665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CAI18_RS10680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAI18_RS10690	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CAI18_RS10695	COG3734	2-keto-3-deoxy-galactonokinase
CAI18_RS10705	COG4948	Mandelate Racemase Muconate Lactonizing
CAI18_RS10710	COG0800	Aldolase
CAI18_RS10745	COG1501	Belongs to the glycosyl hydrolase 31 family
CAI18_RS10755	COG1070	Carbohydrate kinase
CAI18_RS10760	COG2115	Belongs to the xylose isomerase family
CAI18_RS10765	COG0477	Major facilitator Superfamily
CAI18_RS10780	COG0860	N-Acetylmuramoyl-L-alanine amidase
CAI18_RS10785	COG1469	GTP cyclohydrolase I activity
CAI18_RS10805	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CAI18_RS10810	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CAI18_RS10815	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CAI18_RS10820	COG0166	Belongs to the GPI family
CAI18_RS10840	COG1472	Belongs to the glycosyl hydrolase 3 family
CAI18_RS10850	COG2203	Gaf domain
CAI18_RS10850	COG3706	GGDEF domain
CAI18_RS10850	COG4251	negative regulation of phosphorylation
CAI18_RS10850	COG5001	Diguanylate cyclase
CAI18_RS10855	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI18_RS10860	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CAI18_RS10870	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CAI18_RS10875	COG0671	phosphoesterase, PA-phosphatase related
CAI18_RS10905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CAI18_RS10910	COG0167	dihydroorotate dehydrogenase activity
CAI18_RS10925	COG1012	belongs to the aldehyde dehydrogenase family
CAI18_RS10955	COG0326	Molecular chaperone. Has ATPase activity
CAI18_RS10960	COG0742	ribosomal rna small subunit methyltransferase
CAI18_RS10965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CAI18_RS10975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CAI18_RS10980	COG0405	Gamma-glutamyltransferase
CAI18_RS10985	COG3291	Pkd domain containing protein
CAI18_RS10990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CAI18_RS11025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CAI18_RS11030	COG0343	queuine tRNA-ribosyltransferase activity
CAI18_RS11035	COG1862	Preprotein translocase
CAI18_RS11045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAI18_RS11080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAI18_RS11080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAI18_RS11085	COG1105	Belongs to the carbohydrate kinase PfkB family
CAI18_RS11090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAI18_RS11090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAI18_RS11095	COG1609	Transcriptional regulator
CAI18_RS11105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI18_RS11110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI18_RS11120	COG2902	Dehydrogenase
CAI18_RS11155	COG1238	metal cluster binding
CAI18_RS11175	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS11205	COG2226	methyltransferase
CAI18_RS11205	COG1073	alpha beta
CAI18_RS11290	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CAI18_RS11290	COG0316	Belongs to the HesB IscA family
CAI18_RS11295	COG2154	pterin-4-alpha-carbinolamine dehydratase
CAI18_RS11305	COG0428	transporter
CAI18_RS11310	COG3064	Membrane
CAI18_RS11320	COG1530	ribonuclease E activity
CAI18_RS11350	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CAI18_RS11375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAI18_RS11455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAI18_RS11460	COG0322	excinuclease ABC activity
CAI18_RS11470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CAI18_RS11475	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CAI18_RS11480	COG1663	tetraacyldisaccharide 4'-kinase activity
CAI18_RS11485	COG1132	(ABC) transporter
CAI18_RS11495	COG0811	peptide transport
CAI18_RS11510	COG1136	(ABC) transporter
CAI18_RS11515	COG4591	ABC-type transport system involved in lipoprotein release permease component
CAI18_RS11525	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CAI18_RS11545	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CAI18_RS11570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CAI18_RS11575	COG0837	glucose binding
CAI18_RS11580	COG0363	glucosamine-6-phosphate deaminase activity
CAI18_RS11585	COG0129	dihydroxy-acid dehydratase activity
CAI18_RS11590	COG0800	Aldolase
CAI18_RS11655	COG2205	protein histidine kinase activity
CAI18_RS11655	COG0784	Response regulator, receiver
CAI18_RS11660	COG2183	response to ionizing radiation
CAI18_RS11670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI18_RS11670	COG0723	plastoquinol--plastocyanin reductase activity
CAI18_RS11685	COG3243	poly(R)-hydroxyalkanoic acid synthase
CAI18_RS11695	COG1183	phosphatidylcholine synthase activity
CAI18_RS11700	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS11715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CAI18_RS11725	COG0668	transmembrane transport
CAI18_RS11740	COG4456	Virulence-associated protein
CAI18_RS11825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI18_RS11855	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CAI18_RS11870	COG1914	H( )-stimulated, divalent metal cation uptake system
CAI18_RS11890	COG2814	Major facilitator Superfamily
CAI18_RS11915	COG1335	isochorismatase
CAI18_RS11935	COG2197	response regulator
CAI18_RS11955	COG0583	DNA-binding transcription factor activity
CAI18_RS11960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAI18_RS11965	COG3002	Belongs to the UPF0753 family
CAI18_RS11970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAI18_RS11970	COG0519	Catalyzes the synthesis of GMP from XMP
CAI18_RS11980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CAI18_RS11990	COG0475	glutathione-regulated potassium exporter activity
CAI18_RS11990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAI18_RS11995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CAI18_RS12005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAI18_RS12010	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CAI18_RS12020	COG0776	regulation of translation
CAI18_RS12025	COG0539	negative regulation of cytoplasmic translation
CAI18_RS12030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CAI18_RS12050	COG2957	Belongs to the agmatine deiminase family
CAI18_RS12055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAI18_RS12080	COG0395	ABC-type sugar transport system, permease component
CAI18_RS12085	COG1175	transmembrane transport
CAI18_RS12115	COG2350	Protein conserved in bacteria
CAI18_RS12120	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CAI18_RS12125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CAI18_RS12130	COG1187	pseudouridine synthase activity
CAI18_RS12150	COG0436	Aminotransferase
CAI18_RS12155	COG4133	protoheme IX ABC transporter activity
CAI18_RS12175	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CAI18_RS12180	COG1138	Cytochrome C-type biogenesis protein
CAI18_RS12200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAI18_RS12205	COG1278	Cold shock
CAI18_RS12210	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CAI18_RS12215	COG4988	ABC transporter
CAI18_RS12225	COG1294	oxidase, subunit
CAI18_RS12235	COG3344	reverse transcriptase
CAI18_RS12255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CAI18_RS12260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CAI18_RS12270	COG0165	Argininosuccinate lyase
CAI18_RS12275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CAI18_RS12285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CAI18_RS12290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAI18_RS12300	COG0137	argininosuccinate synthase activity
CAI18_RS12305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CAI18_RS12315	COG0215	cysteine-tRNA ligase activity
CAI18_RS12320	COG2166	iron-sulfur cluster assembly
CAI18_RS12335	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CAI18_RS12340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAI18_RS12370	COG4302	ethanolamine ammonia-lyase activity
CAI18_RS12430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAI18_RS12435	COG0402	S-adenosylhomocysteine deaminase activity
CAI18_RS12445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CAI18_RS12450	COG1509	lysine 2,3-aminomutase activity
CAI18_RS12455	COG5001	Diguanylate cyclase
CAI18_RS12455	COG3300	MHYT domain
CAI18_RS12470	COG0483	inositol monophosphate 1-phosphatase activity
CAI18_RS12475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CAI18_RS12495	COG0513	Belongs to the DEAD box helicase family
CAI18_RS12500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CAI18_RS12505	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CAI18_RS12515	COG0625	glutathione transferase activity
CAI18_RS12525	COG4681	YaeQ
CAI18_RS12530	COG2081	HI0933 family
CAI18_RS12565	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI18_RS12575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAI18_RS12605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CAI18_RS12610	COG0860	N-Acetylmuramoyl-L-alanine amidase
CAI18_RS12615	COG0802	atpase or kinase
CAI18_RS12620	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CAI18_RS12620	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CAI18_RS12625	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CAI18_RS12630	COG1570	exodeoxyribonuclease VII activity
CAI18_RS12640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAI18_RS12685	COG0835	chemotaxis
CAI18_RS12690	COG0840	transmembrane signaling receptor activity
CAI18_RS12695	COG2094	Belongs to the DNA glycosylase MPG family
CAI18_RS12700	COG1201	RNA secondary structure unwinding
CAI18_RS12720	COG2969	positive regulation of protein catabolic process
CAI18_RS12725	COG0625	glutathione transferase activity
CAI18_RS12730	COG2857	Cytochrome c1
CAI18_RS12735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CAI18_RS12745	COG0741	lytic transglycosylase activity
CAI18_RS12760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAI18_RS12765	COG1702	phosphate starvation-inducible protein PhoH
CAI18_RS12775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CAI18_RS12785	COG4535	Mg2 and Co2 transporter CorC
CAI18_RS12800	COG1012	belongs to the aldehyde dehydrogenase family
CAI18_RS12805	COG1177	transmembrane transport
CAI18_RS12810	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAI18_RS12815	COG3842	ATPase activity
CAI18_RS12835	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CAI18_RS12850	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CAI18_RS12855	COG0174	glutamine synthetase
CAI18_RS12860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI18_RS12870	COG2703	oxygen carrier activity
CAI18_RS12875	COG0477	Major facilitator Superfamily
CAI18_RS12885	COG0243	molybdopterin cofactor binding
CAI18_RS12890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CAI18_RS12895	COG2223	nitrite transmembrane transporter activity
CAI18_RS12910	COG2733	membrane
CAI18_RS12915	COG0784	Response regulator, receiver
CAI18_RS12915	COG2205	protein histidine kinase activity
CAI18_RS12915	COG5002	protein histidine kinase activity
CAI18_RS12925	COG0477	Major facilitator Superfamily
CAI18_RS12950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI18_RS12970	COG4566	intracellular signal transduction
CAI18_RS13000	COG3685	Protein conserved in bacteria
CAI18_RS13035	COG1648	precorrin-2 dehydrogenase activity
CAI18_RS13035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAI18_RS13045	COG0746	molybdenum cofactor guanylyltransferase activity
CAI18_RS13060	COG0708	Exodeoxyribonuclease III
CAI18_RS13095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CAI18_RS13105	COG0303	'Molybdopterin
CAI18_RS13110	COG1160	GTP binding
CAI18_RS13115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAI18_RS13125	COG1426	Protein conserved in bacteria
CAI18_RS13135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CAI18_RS13150	COG1024	Enoyl-CoA hydratase
CAI18_RS13150	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAI18_RS13155	COG0183	Belongs to the thiolase family
CAI18_RS13160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CAI18_RS13165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CAI18_RS13175	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CAI18_RS13185	COG1674	ftsk spoiiie
CAI18_RS13190	COG0492	ferredoxin-NADP+ reductase activity
CAI18_RS13210	COG0542	response to heat
CAI18_RS13225	COG0482	sulfurtransferase activity
CAI18_RS13230	COG2915	High frequency lysogenization protein hflD homolog
CAI18_RS13260	COG5002	protein histidine kinase activity
CAI18_RS13280	COG0835	chemotaxis
CAI18_RS13280	COG0784	Response regulator, receiver
CAI18_RS13290	COG1558	bacterial-type flagellum-dependent cell motility
CAI18_RS13295	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CAI18_RS13305	COG4787	bacterial-type flagellum-dependent cell motility
CAI18_RS13315	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CAI18_RS13320	COG1706	bacterial-type flagellum-dependent cell motility
CAI18_RS13335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAI18_RS13340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAI18_RS13350	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CAI18_RS13380	COG2201	protein-glutamate methylesterase activity
CAI18_RS13425	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS13430	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS13475	COG1677	Flagellar hook-basal body complex protein FliE
CAI18_RS13540	COG1684	flagellar biosynthetic protein fliR
CAI18_RS13545	COG3300	MHYT domain
CAI18_RS13545	COG5001	Diguanylate cyclase
CAI18_RS13565	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAI18_RS13595	COG0784	Response regulator, receiver
CAI18_RS13595	COG2198	Histidine kinase
CAI18_RS13595	COG0643	Histidine kinase
CAI18_RS13605	COG0641	radical SAM
CAI18_RS13630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CAI18_RS13635	COG1360	Flagellar Motor Protein
CAI18_RS13645	COG0835	chemotaxis
CAI18_RS13655	COG0745	RESPONSE REGULATOR receiver
CAI18_RS13660	COG2198	Histidine kinase
CAI18_RS13660	COG0643	Histidine kinase
CAI18_RS13665	COG0840	transmembrane signaling receptor activity
CAI18_RS13680	COG0840	transmembrane signaling receptor activity
CAI18_RS13690	COG0840	transmembrane signaling receptor activity
CAI18_RS13695	COG0840	transmembrane signaling receptor activity
CAI18_RS13705	COG0840	transmembrane signaling receptor activity
CAI18_RS13710	COG0840	transmembrane signaling receptor activity
CAI18_RS13720	COG0840	transmembrane signaling receptor activity
CAI18_RS13725	COG0840	transmembrane signaling receptor activity
CAI18_RS13730	COG0840	transmembrane signaling receptor activity
CAI18_RS13735	COG0840	transmembrane signaling receptor activity
CAI18_RS13740	COG0840	transmembrane signaling receptor activity
CAI18_RS13750	COG0835	chemotaxis
CAI18_RS13760	COG0840	transmembrane signaling receptor activity
CAI18_RS13770	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CAI18_RS13775	COG2201	protein-glutamate methylesterase activity
CAI18_RS13785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAI18_RS13815	COG0318	PFAM AMP-dependent synthetase and ligase
CAI18_RS13845	COG1024	Enoyl-CoA hydratase
CAI18_RS13850	COG2198	Histidine kinase
CAI18_RS13850	COG0784	Response regulator, receiver
CAI18_RS13850	COG2205	protein histidine kinase activity
CAI18_RS13860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CAI18_RS13870	COG3279	Response regulator of the LytR AlgR family
CAI18_RS13925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CAI18_RS13935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAI18_RS13940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CAI18_RS13950	COG0505	Belongs to the CarA family
CAI18_RS13955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CAI18_RS13960	COG2258	MOSC domain
CAI18_RS14010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CAI18_RS14030	COG0277	FAD linked oxidase domain protein
CAI18_RS14035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAI18_RS14045	COG0531	amino acid
CAI18_RS14050	COG0531	amino acid
CAI18_RS14055	COG0235	Class ii aldolase
CAI18_RS14060	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CAI18_RS14065	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CAI18_RS14080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CAI18_RS14080	COG0140	phosphoribosyl-ATP diphosphatase activity
CAI18_RS14085	COG0107	imidazoleglycerol-phosphate synthase activity
CAI18_RS14090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CAI18_RS14095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CAI18_RS14100	COG0131	Imidazoleglycerol-phosphate dehydratase
CAI18_RS14100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CAI18_RS14105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAI18_RS14110	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CAI18_RS14115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CAI18_RS14125	COG0124	histidyl-tRNA synthetase
CAI18_RS14130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAI18_RS14225	COG0726	polysaccharide deacetylase
CAI18_RS14225	COG1649	PFAM Uncharacterised BCR, COG1649
CAI18_RS14360	COG0531	amino acid
CAI18_RS14375	COG0006	proline dipeptidase activity
CAI18_RS14385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAI18_RS14400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI18_RS14405	COG3938	Belongs to the proline racemase family
CAI18_RS14415	COG0552	protein localization to endoplasmic reticulum
CAI18_RS14420	COG1194	a g-specific adenine glycosylase
CAI18_RS14425	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CAI18_RS14430	COG0784	Response regulator, receiver
CAI18_RS14430	COG4191	Histidine kinase
CAI18_RS14470	COG3040	lipid binding
CAI18_RS14485	COG1960	acyl-CoA dehydrogenase activity
CAI18_RS14495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CAI18_RS14515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAI18_RS14520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAI18_RS14525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAI18_RS14550	COG0438	transferase activity, transferring glycosyl groups
CAI18_RS14560	COG0438	transferase activity, transferring glycosyl groups
CAI18_RS14565	COG0438	transferase activity, transferring glycosyl groups
CAI18_RS14620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAI18_RS14620	COG0072	phenylalanine-tRNA ligase activity
CAI18_RS14625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CAI18_RS14640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CAI18_RS14645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CAI18_RS14695	COG2948	multi-organism process
CAI18_RS14715	COG3505	Type IV secretory pathway VirD4
CAI18_RS14730	COG0556	nucleotide-excision repair
CAI18_RS14785	COG1611	Belongs to the LOG family
CAI18_RS14795	COG2095	MarC family integral membrane protein
CAI18_RS14805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CAI18_RS14840	COG1185	polyribonucleotide nucleotidyltransferase activity
CAI18_RS14845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CAI18_RS14850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CAI18_RS14855	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CAI18_RS14860	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CAI18_RS14865	COG0195	Participates in both transcription termination and antitermination
CAI18_RS14870	COG0779	Required for maturation of 30S ribosomal subunits
CAI18_RS14880	COG1007	ATP synthesis coupled electron transport
CAI18_RS14900	COG0839	Belongs to the complex I subunit 6 family
CAI18_RS14905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI18_RS14910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CAI18_RS14920	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CAI18_RS14925	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CAI18_RS14930	COG0649	NAD binding
CAI18_RS14935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI18_RS14940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI18_RS14945	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI18_RS14960	COG0149	triose-phosphate isomerase activity
CAI18_RS14965	COG0300	oxidoreductase activity
CAI18_RS14995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAI18_RS15000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CAI18_RS15005	COG0159	tryptophan synthase activity
CAI18_RS15015	COG0133	tryptophan synthase activity
CAI18_RS15025	COG0135	phosphoribosylanthranilate isomerase activity
CAI18_RS15030	COG0101	tRNA pseudouridine synthase activity
CAI18_RS15055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAI18_RS15060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CAI18_RS15065	COG2890	protein-(glutamine-N5) methyltransferase activity
CAI18_RS15075	COG0688	phosphatidylethanolamine metabolic process
CAI18_RS15085	COG0433	COG0433 Predicted ATPase
CAI18_RS15090	COG0494	nUDIX hydrolase
CAI18_RS15105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAI18_RS15110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAI18_RS15125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CAI18_RS15155	COG4695	Portal protein
CAI18_RS15200	COG3179	chitinase
CAI18_RS15400	COG0717	Belongs to the dCTP deaminase family
CAI18_RS15405	COG0489	protein tyrosine kinase activity
CAI18_RS15430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CAI18_RS15440	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CAI18_RS15460	COG0534	Mate efflux family protein
CAI18_RS15465	COG0335	large ribosomal subunit rRNA binding
CAI18_RS15470	COG0336	Belongs to the RNA methyltransferase TrmD family
CAI18_RS15475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CAI18_RS15480	COG0228	four-way junction DNA binding
CAI18_RS15485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAI18_RS15495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CAI18_RS15500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAI18_RS15545	COG4999	Histidine kinase
CAI18_RS15545	COG3850	Histidine kinase
CAI18_RS15545	COG2205	protein histidine kinase activity
CAI18_RS15545	COG3437	response regulator, receiver
CAI18_RS15550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CAI18_RS15560	COG2205	protein histidine kinase activity
CAI18_RS15565	COG5507	3-demethylubiquinone-9 3-methyltransferase
CAI18_RS15575	COG4771	TonB-dependent receptor
CAI18_RS15600	COG2172	sigma factor antagonist activity
CAI18_RS15605	COG1366	Belongs to the anti-sigma-factor antagonist family
CAI18_RS15610	COG1366	Belongs to the anti-sigma-factor antagonist family
CAI18_RS15625	COG0326	Molecular chaperone. Has ATPase activity
CAI18_RS15630	COG2207	Transcriptional regulator
CAI18_RS15640	COG3152	Membrane
CAI18_RS15655	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CAI18_RS15660	COG1845	cytochrome c oxidase, subunit III
CAI18_RS15665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAI18_RS15680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CAI18_RS15685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CAI18_RS15690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CAI18_RS15695	COG0196	riboflavin kinase activity
CAI18_RS15705	COG0268	Binds directly to 16S ribosomal RNA
CAI18_RS15710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CAI18_RS15715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CAI18_RS15720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CAI18_RS15725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CAI18_RS15730	COG0824	Thioesterase
CAI18_RS15775	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CAI18_RS15785	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CAI18_RS15810	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CAI18_RS15825	COG2197	response regulator
CAI18_RS15830	COG4585	Histidine kinase
CAI18_RS15840	COG0850	regulation of cytokinetic process
CAI18_RS15845	COG2894	cell division
CAI18_RS15850	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CAI18_RS15860	COG0642	Histidine kinase
CAI18_RS15865	COG0745	RESPONSE REGULATOR receiver
CAI18_RS15880	COG2194	sulfuric ester hydrolase activity
CAI18_RS15895	COG2814	Major facilitator Superfamily
CAI18_RS15900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAI18_RS15900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAI18_RS15910	COG0656	L-ascorbic acid biosynthetic process
CAI18_RS15915	COG0753	catalase activity
CAI18_RS15935	COG1917	Cupin 2, conserved barrel domain protein
CAI18_RS15935	COG2207	Transcriptional regulator
CAI18_RS15995	COG0492	ferredoxin-NADP+ reductase activity
CAI18_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS16010	COG3537	Alpha-1,2-mannosidase
CAI18_RS16015	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS16020	COG3387	PFAM Glycoside hydrolase 15-related
CAI18_RS16030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CAI18_RS16060	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CAI18_RS16085	COG0732	type I restriction modification DNA specificity domain
CAI18_RS16115	COG1309	transcriptional regulator
CAI18_RS16120	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS16125	COG0308	aminopeptidase N
CAI18_RS16130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CAI18_RS16140	COG0330	HflC and HflK could
CAI18_RS16145	COG0330	HflC and HflK could
CAI18_RS16165	COG0678	peroxiredoxin activity
CAI18_RS16175	COG4953	penicillin-binding protein 1C
CAI18_RS16190	COG2373	Large extracellular alpha-helical protein
CAI18_RS16215	COG3609	addiction module antidote protein, CC2985 family
CAI18_RS16235	COG3829	transcription factor binding
CAI18_RS16260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CAI18_RS16265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CAI18_RS16280	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS16295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAI18_RS16300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CAI18_RS16305	COG1399	metal-binding, possibly nucleic acid-binding protein
CAI18_RS16310	COG0424	maF-like protein
CAI18_RS16340	COG0714	Associated with various cellular activities
CAI18_RS16360	COG0537	adenosine 5'-monophosphoramidase activity
CAI18_RS16365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CAI18_RS16370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CAI18_RS16390	COG0314	molybdopterin synthase activity
CAI18_RS16395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CAI18_RS16400	COG0315	cyclic pyranopterin monophosphate synthase activity
CAI18_RS16405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CAI18_RS16410	COG1234	tRNA 3'-trailer cleavage
CAI18_RS16415	COG3642	lipopolysaccharide core region biosynthetic process
CAI18_RS16420	COG0859	PFAM glycosyl transferase family 9
CAI18_RS16435	COG0631	protein serine/threonine phosphatase activity
CAI18_RS16440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAI18_RS16445	COG0328	RNA-DNA hybrid ribonuclease activity
CAI18_RS16455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAI18_RS16465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAI18_RS16490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CAI18_RS16500	COG0544	peptidyl-prolyl cis-trans isomerase activity
CAI18_RS16510	COG3852	Histidine kinase
CAI18_RS16540	COG0473	3-isopropylmalate dehydrogenase activity
CAI18_RS16555	COG4783	chaperone-mediated protein folding
CAI18_RS16570	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CAI18_RS16580	COG0438	transferase activity, transferring glycosyl groups
CAI18_RS16585	COG0671	phosphoesterase, PA-phosphatase related
CAI18_RS16590	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAI18_RS16605	COG2833	Protein of unknown function (DUF455)
CAI18_RS16625	COG0285	dihydrofolate synthase activity
CAI18_RS16640	COG0406	alpha-ribazole phosphatase activity
CAI18_RS16670	COG1063	alcohol dehydrogenase
CAI18_RS16680	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CAI18_RS16685	COG4208	sulfate ABC transporter
CAI18_RS16690	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CAI18_RS16695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CAI18_RS16700	COG0156	8-amino-7-oxononanoate synthase activity
CAI18_RS16730	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAI18_RS16730	COG1902	pentaerythritol trinitrate reductase activity
CAI18_RS16740	COG0625	glutathione transferase activity
CAI18_RS16750	COG0039	L-malate dehydrogenase activity
CAI18_RS16755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CAI18_RS16770	COG0154	amidase activity
CAI18_RS16780	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CAI18_RS16795	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CAI18_RS16800	COG0203	ribosomal protein L17
CAI18_RS16825	COG0201	protein transport
CAI18_RS16830	COG0200	Binds to the 23S rRNA
CAI18_RS16835	COG1841	ribosomal large subunit assembly
CAI18_RS16845	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CAI18_RS16850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CAI18_RS16855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CAI18_RS16865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CAI18_RS16870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CAI18_RS16880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CAI18_RS16885	COG0255	Belongs to the universal ribosomal protein uL29 family
CAI18_RS16890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CAI18_RS16895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CAI18_RS16905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CAI18_RS16910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CAI18_RS16915	COG0089	rRNA binding
CAI18_RS16920	COG0088	Forms part of the polypeptide exit tunnel
CAI18_RS16925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CAI18_RS16930	COG0051	transcription antitermination factor activity, RNA binding
CAI18_RS16935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAI18_RS16940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAI18_RS16945	COG0049	tRNA binding
CAI18_RS16950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CAI18_RS16955	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CAI18_RS16960	COG0085	RNA polymerase activity
CAI18_RS16965	COG0222	ribosome binding
CAI18_RS16970	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CAI18_RS16975	COG0081	regulation of translation
CAI18_RS16980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CAI18_RS16985	COG0250	Participates in transcription elongation, termination and antitermination
CAI18_RS17000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAI18_RS17020	COG0012	GTP binding
CAI18_RS17025	COG0193	aminoacyl-tRNA hydrolase activity
CAI18_RS17030	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CAI18_RS17035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CAI18_RS17045	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CAI18_RS17050	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CAI18_RS17060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CAI18_RS17065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CAI18_RS17095	COG1254	Belongs to the acylphosphatase family
CAI18_RS17105	COG1295	ribonuclease BN
CAI18_RS17130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CAI18_RS17135	COG1404	Belongs to the peptidase S8 family
CAI18_RS17140	COG1404	Belongs to the peptidase S8 family
CAI18_RS17145	COG1404	Belongs to the peptidase S8 family
CAI18_RS17150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAI18_RS17170	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CAI18_RS17190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CAI18_RS17220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAI18_RS17220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAI18_RS17240	COG2890	protein-(glutamine-N5) methyltransferase activity
CAI18_RS17250	COG3634	alkyl hydroperoxide reductase activity
CAI18_RS17255	COG0583	DNA-binding transcription factor activity
CAI18_RS17260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAI18_RS17265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CAI18_RS17275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAI18_RS17310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAI18_RS17315	COG0697	spore germination
CAI18_RS17340	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CAI18_RS17355	COG3386	PFAM SMP-30 Gluconolaconase
CAI18_RS17375	COG1024	Enoyl-CoA hydratase
CAI18_RS17385	COG0318	PFAM AMP-dependent synthetase and ligase
CAI18_RS17390	COG0583	DNA-binding transcription factor activity
CAI18_RS17395	COG3384	dioxygenase
CAI18_RS17425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAI18_RS17430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAI18_RS17440	COG2096	Adenosyltransferase
CAI18_RS17445	COG0123	including yeast histone deacetylase and acetoin utilization protein
CAI18_RS17450	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CAI18_RS17455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAI18_RS17460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CAI18_RS17465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CAI18_RS17470	COG2967	ApaG domain
CAI18_RS17475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CAI18_RS17495	COG0747	negative chemotaxis
CAI18_RS17520	COG0431	NADPH-dependent FMN reductase
CAI18_RS17525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAI18_RS17535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAI18_RS17540	COG1116	anion transmembrane transporter activity
CAI18_RS17550	COG3829	transcription factor binding
CAI18_RS17565	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CAI18_RS17570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CAI18_RS17605	COG0588	phosphoglycerate mutase activity
CAI18_RS17610	COG1515	deoxyribonuclease V activity
CAI18_RS17620	COG1741	Belongs to the pirin family
CAI18_RS17635	COG1741	Belongs to the pirin family
CAI18_RS17640	COG1966	Carbon starvation protein
CAI18_RS17645	COG2879	small protein
CAI18_RS17680	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CAI18_RS17685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAI18_RS17690	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CAI18_RS17695	COG2080	2 iron, 2 sulfur cluster binding
CAI18_RS17700	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS17700	COG0604	alcohol dehydrogenase
CAI18_RS17700	COG3321	synthase
CAI18_RS17705	COG2203	Gaf domain
CAI18_RS17705	COG5001	Diguanylate cyclase
CAI18_RS17705	COG3706	GGDEF domain
CAI18_RS17705	COG4251	negative regulation of phosphorylation
CAI18_RS17710	COG0629	single-stranded DNA binding
CAI18_RS17715	COG0142	geranyltranstransferase activity
CAI18_RS17730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CAI18_RS17745	COG0527	aspartate kinase activity
CAI18_RS17750	COG0384	phenazine biosynthesis protein PhzF
CAI18_RS17765	COG1764	response to oxidative stress
CAI18_RS17770	COG0540	Belongs to the ATCase OTCase family
CAI18_RS17775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CAI18_RS17780	COG1678	Uncharacterized ACR, COG1678
CAI18_RS17785	COG0519	Catalyzes the synthesis of GMP from XMP
CAI18_RS17800	COG5297	Belongs to the glycosyl hydrolase family 6
CAI18_RS17815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CAI18_RS17830	COG0739	heme binding
CAI18_RS17850	COG0693	protein deglycase activity
CAI18_RS17860	COG1959	2 iron, 2 sulfur cluster binding
CAI18_RS17865	COG0719	Fe-S assembly protein
CAI18_RS17870	COG0396	ATPase activity
CAI18_RS17875	COG0719	Fe-S assembly protein
CAI18_RS17880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAI18_RS17890	COG2146	nitrite reductase [NAD(P)H] activity
CAI18_RS17895	COG4774	siderophore transport
CAI18_RS17900	COG3128	pkhd-type hydroxylase
CAI18_RS17925	COG1477	protein flavinylation
CAI18_RS17930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CAI18_RS17945	COG1555	photosystem II stabilization
CAI18_RS17960	COG3178	'Phosphotransferase
CAI18_RS17965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CAI18_RS17975	COG0628	permease
CAI18_RS17985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CAI18_RS17995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CAI18_RS18015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAI18_RS18020	COG0271	Belongs to the BolA IbaG family
CAI18_RS18030	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CAI18_RS18040	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CAI18_RS18045	COG1137	ATPase activity
CAI18_RS18060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAI18_RS18065	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CAI18_RS18070	COG1660	Displays ATPase and GTPase activities
CAI18_RS18080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAI18_RS18085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAI18_RS18090	COG2239	Acts as a magnesium transporter
CAI18_RS18105	COG1294	oxidase, subunit
CAI18_RS18110	COG1271	oxidase subunit
CAI18_RS18130	COG1113	amino acid transport
CAI18_RS18150	COG2197	response regulator
CAI18_RS18155	COG0531	amino acid
CAI18_RS18175	COG1234	tRNA 3'-trailer cleavage
CAI18_RS18230	COG2814	Major facilitator Superfamily
CAI18_RS18240	COG0754	glutathionylspermidine amidase activity
CAI18_RS18265	COG1842	Phage shock protein A
CAI18_RS18275	COG0259	pyridoxamine-phosphate oxidase activity
CAI18_RS18280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CAI18_RS18285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CAI18_RS18295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CAI18_RS18300	COG0477	Major facilitator Superfamily
CAI18_RS18320	COG2205	protein histidine kinase activity
CAI18_RS18320	COG2198	Histidine kinase
CAI18_RS18320	COG0784	Response regulator, receiver
CAI18_RS18325	COG2353	YceI-like domain
CAI18_RS18345	COG1760	l-serine dehydratase
CAI18_RS18355	COG0527	aspartate kinase activity
CAI18_RS18355	COG0460	homoserine dehydrogenase
CAI18_RS18360	COG0626	cystathionine gamma-synthase activity
CAI18_RS18365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAI18_RS18370	COG0739	heme binding
CAI18_RS18375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CAI18_RS18380	COG1272	protein, Hemolysin III
CAI18_RS18385	COG2982	Protein involved in outer membrane biogenesis
CAI18_RS18390	COG0516	GMP reductase activity
CAI18_RS18390	COG0517	IMP dehydrogenase activity
CAI18_RS18395	COG0463	Glycosyl transferase, family 2
CAI18_RS18400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAI18_RS18405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CAI18_RS18430	COG1309	transcriptional regulator
CAI18_RS18440	COG1960	acyl-CoA dehydrogenase activity
CAI18_RS18470	COG0509	glycine decarboxylation via glycine cleavage system
CAI18_RS18475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAI18_RS18490	COG1742	UPF0060 membrane protein
CAI18_RS18495	COG3956	TIGRFAM MazG family protein
CAI18_RS18505	COG0494	nUDIX hydrolase
CAI18_RS18515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CAI18_RS18520	COG0837	glucose binding
CAI18_RS18535	COG1388	LysM domain
CAI18_RS18535	COG3858	chitin binding
CAI18_RS18540	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CAI18_RS18550	COG1472	Belongs to the glycosyl hydrolase 3 family
CAI18_RS18585	COG3537	Alpha-1,2-mannosidase
CAI18_RS18620	COG3142	Participates in the control of copper homeostasis
CAI18_RS18625	COG1446	asparaginase
CAI18_RS18645	COG0643	Histidine kinase
CAI18_RS18645	COG2198	Histidine kinase
CAI18_RS18645	COG0784	Response regulator, receiver
CAI18_RS18650	COG0840	transmembrane signaling receptor activity
CAI18_RS18655	COG0835	chemotaxis
CAI18_RS18670	COG0189	ligase activity
CAI18_RS18680	COG1397	ADP-ribosylglycohydrolase
CAI18_RS18690	COG1199	ATP-dependent helicase activity
CAI18_RS18700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAI18_RS18705	COG1215	transferase activity, transferring glycosyl groups
CAI18_RS18725	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CAI18_RS18730	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CAI18_RS18735	COG0535	radical SAM domain protein
CAI18_RS18740	COG0535	radical SAM domain protein
CAI18_RS18765	COG1643	Atp-dependent helicase
CAI18_RS18770	COG0783	Belongs to the Dps family
CAI18_RS18775	COG0514	ATP-dependent DNA helicase (RecQ)
CAI18_RS18805	COG0840	transmembrane signaling receptor activity
CAI18_RS18825	COG3920	Histidine kinase
CAI18_RS18830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CAI18_RS18840	COG0602	queuosine metabolic process
CAI18_RS18850	COG2885	chlorophyll binding
CAI18_RS18855	COG0823	Involved in the tonB-independent uptake of proteins
CAI18_RS18865	COG0848	biopolymer transport protein
CAI18_RS18875	COG0824	Thioesterase
CAI18_RS18880	COG2255	four-way junction helicase activity
CAI18_RS18890	COG3158	transport of potassium into the cell
CAI18_RS18895	COG0632	four-way junction helicase activity
CAI18_RS18900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CAI18_RS18905	COG0217	transcriptional regulatory protein
CAI18_RS18920	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CAI18_RS18935	COG0477	Major facilitator Superfamily
CAI18_RS18975	COG0488	(ABC) transporter
CAI18_RS19005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAI18_RS19005	COG4651	solute:proton antiporter activity
CAI18_RS19030	COG4772	TonB-dependent receptor
CAI18_RS19040	COG4264	IucA IucC family
CAI18_RS19055	COG0019	diaminopimelate decarboxylase activity
CAI18_RS19085	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CAI18_RS19095	COG1492	cobalamin metabolic process
CAI18_RS19125	COG4206	TonB-dependent receptor
CAI18_RS19130	COG0542	response to heat
CAI18_RS19135	COG1116	anion transmembrane transporter activity
CAI18_RS19140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAI18_RS19145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAI18_RS19150	COG0667	Aldo Keto reductase
CAI18_RS19155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAI18_RS19160	COG4771	TonB-dependent receptor
CAI18_RS19170	COG2827	Endonuclease containing a URI domain
CAI18_RS19210	COG1877	trehalose-phosphatase activity
CAI18_RS19215	COG3387	PFAM Glycoside hydrolase 15-related
CAI18_RS19230	COG0840	transmembrane signaling receptor activity
CAI18_RS19235	COG3011	Protein conserved in bacteria
CAI18_RS19250	COG0564	pseudouridine synthase activity
CAI18_RS19255	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAI18_RS19265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAI18_RS19265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CAI18_RS19275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CAI18_RS19280	COG0045	succinate-CoA ligase (ADP-forming) activity
CAI18_RS19315	COG1459	type II secretion system
CAI18_RS19320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CAI18_RS19325	COG0237	dephospho-CoA kinase activity
CAI18_RS19345	COG0436	Aminotransferase
CAI18_RS19365	COG0726	polysaccharide deacetylase
CAI18_RS19370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CAI18_RS19385	COG3964	amidohydrolase
CAI18_RS19390	COG0402	S-adenosylhomocysteine deaminase activity
CAI18_RS19420	COG1307	EDD domain protein, DegV family
CAI18_RS19425	COG0242	peptide deformylase activity
CAI18_RS19445	COG0457	Tetratricopeptide repeat
CAI18_RS19450	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CAI18_RS19455	COG1215	transferase activity, transferring glycosyl groups
CAI18_RS19460	COG1215	transferase activity, transferring glycosyl groups
CAI18_RS19475	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CAI18_RS19530	COG2188	Transcriptional regulator
CAI18_RS19545	COG1450	Type ii and iii secretion system protein
CAI18_RS19560	COG3166	PFAM Fimbrial assembly family protein
CAI18_RS19565	COG3156	type II secretion system protein K
CAI18_RS19570	COG4795	General secretion pathway protein
CAI18_RS19575	COG2165	general secretion pathway protein
CAI18_RS19580	COG4970	Tfp pilus assembly protein FimT
CAI18_RS19585	COG2165	general secretion pathway protein
CAI18_RS19590	COG1459	type II secretion system
CAI18_RS19595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CAI18_RS19600	COG1404	Belongs to the peptidase S8 family
CAI18_RS19605	COG5295	Hep Hag repeat protein
CAI18_RS19610	COG1404	Belongs to the peptidase S8 family
CAI18_RS19615	COG5295	Hep Hag repeat protein
CAI18_RS19620	COG0047	phosphoribosylformylglycinamidine synthase activity
CAI18_RS19620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAI18_RS19625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAI18_RS19630	COG4974	Belongs to the 'phage' integrase family
CAI18_RS19645	COG0795	lipopolysaccharide-transporting ATPase activity
CAI18_RS19655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CAI18_RS19670	COG0525	valine-tRNA ligase activity
CAI18_RS19690	COG0741	lytic transglycosylase activity
CAI18_RS19715	COG1183	phosphatidylcholine synthase activity
CAI18_RS19725	COG0442	prolyl-tRNA aminoacylation
CAI18_RS19740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAI18_RS19745	COG1127	ABC transporter
CAI18_RS19750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAI18_RS19750	COG3218	ABC-type transport auxiliary lipoprotein component
CAI18_RS19785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAI18_RS19790	COG0662	Cupin 2, conserved barrel domain protein
CAI18_RS19790	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CAI18_RS19820	COG2086	electron transfer activity
CAI18_RS19835	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CAI18_RS19835	COG0546	phosphoglycolate phosphatase activity
CAI18_RS19840	COG0277	FAD linked oxidase domain protein
CAI18_RS19855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAI18_RS19890	COG1216	Glycosyl transferase, family 2
CAI18_RS19890	COG0438	transferase activity, transferring glycosyl groups
CAI18_RS19910	COG0626	cystathionine gamma-synthase activity
CAI18_RS19940	COG0625	glutathione transferase activity
CAI18_RS19950	COG0513	Belongs to the DEAD box helicase family
CAI18_RS19960	COG4206	TonB-dependent receptor
CAI18_RS19965	COG0720	synthase
CAI18_RS19975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CAI18_RS19980	COG1956	GAF domain-containing protein
CAI18_RS19990	COG2819	hydrolase of the alpha beta superfamily
CAI18_RS20005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CAI18_RS20010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAI18_RS20025	COG0339	signal peptide processing
CAI18_RS20040	COG2132	Multicopper oxidase
CAI18_RS20080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAI18_RS20085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI18_RS20090	COG1136	(ABC) transporter
CAI18_RS20090	COG4591	ABC-type transport system involved in lipoprotein release permease component
CAI18_RS20095	COG0577	efflux transmembrane transporter activity
CAI18_RS20100	COG0577	efflux transmembrane transporter activity
CAI18_RS20115	COG4191	Histidine kinase
CAI18_RS20120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CAI18_RS20135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CAI18_RS20140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CAI18_RS20145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CAI18_RS20150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CAI18_RS20155	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAI18_RS20160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CAI18_RS20170	COG0356	it plays a direct role in the translocation of protons across the membrane
CAI18_RS20190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAI18_RS20200	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAI18_RS20245	COG2011	ABC-type metal ion transport system permease component
CAI18_RS20250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAI18_RS20255	COG0697	spore germination
CAI18_RS20260	COG1666	GTP binding
CAI18_RS20270	COG2198	Histidine kinase
CAI18_RS20270	COG0784	Response regulator, receiver
CAI18_RS20270	COG5002	protein histidine kinase activity
CAI18_RS20290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAI18_RS20295	COG1187	pseudouridine synthase activity
CAI18_RS20300	COG2813	Specifically methylates the guanine in position
CAI18_RS20320	COG2205	protein histidine kinase activity
CAI18_RS20320	COG2202	Pas domain
CAI18_RS20340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CAI18_RS20345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI18_RS20400	COG0842	Transport permease protein
CAI18_RS20405	COG1131	(ABC) transporter
CAI18_RS20410	COG0025	NhaP-type Na H and K H
CAI18_RS20415	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CAI18_RS20420	COG1573	uracil-dna glycosylase
CAI18_RS20430	COG3384	dioxygenase
CAI18_RS20450	COG0667	Aldo Keto reductase
CAI18_RS20460	COG3590	peptidase
CAI18_RS20480	COG0531	amino acid
CAI18_RS20495	COG2972	Histidine kinase
CAI18_RS20510	COG3685	Protein conserved in bacteria
CAI18_RS20515	COG3546	catalase activity
CAI18_RS20560	COG1271	oxidase subunit
CAI18_RS20565	COG1294	oxidase, subunit
CAI18_RS20585	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS20590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CAI18_RS20620	COG1132	(ABC) transporter
CAI18_RS20645	COG1063	alcohol dehydrogenase
CAI18_RS20720	COG0251	oxidation-reduction process
CAI18_RS20735	COG0840	transmembrane signaling receptor activity
CAI18_RS20750	COG0583	DNA-binding transcription factor activity
CAI18_RS20755	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAI18_RS20830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAI18_RS20835	COG1490	D-aminoacyl-tRNA deacylase activity
CAI18_RS20840	COG1560	Kdo2-lipid A biosynthetic process
CAI18_RS20890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAI18_RS20890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CAI18_RS20895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CAI18_RS20900	COG0242	peptide deformylase activity
CAI18_RS20905	COG1652	LysM domain
CAI18_RS20910	COG0758	DNA mediated transformation
CAI18_RS20930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAI18_RS20930	COG1754	DNA topoisomerase type I activity
CAI18_RS20935	COG0009	L-threonylcarbamoyladenylate synthase
CAI18_RS20950	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS20960	COG0616	signal peptide processing
CAI18_RS20965	COG0534	Mate efflux family protein
CAI18_RS20985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CAI18_RS20990	COG0625	glutathione transferase activity
CAI18_RS21005	COG1252	NADH dehydrogenase
CAI18_RS21015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAI18_RS21020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CAI18_RS21025	COG2201	protein-glutamate methylesterase activity
CAI18_RS21030	COG2177	Part of the ABC transporter FtsEX involved in
CAI18_RS21035	COG2884	Cell division ATP-binding protein ftsE
CAI18_RS21040	COG0513	Belongs to the DEAD box helicase family
CAI18_RS21045	COG3118	belongs to the thioredoxin family
CAI18_RS21050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CAI18_RS21055	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CAI18_RS21060	COG0583	DNA-binding transcription factor activity
CAI18_RS21105	COG1518	maintenance of DNA repeat elements
CAI18_RS21110	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CAI18_RS21120	COG1652	LysM domain
CAI18_RS21125	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CAI18_RS21125	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CAI18_RS21130	COG1473	amidohydrolase
CAI18_RS21135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI18_RS21140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI18_RS21150	COG5383	Protein conserved in bacteria
CAI18_RS21190	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CAI18_RS21195	COG3023	N-Acetylmuramoyl-L-alanine amidase
CAI18_RS21205	COG4948	Mandelate Racemase Muconate Lactonizing
CAI18_RS21215	COG0531	amino acid
CAI18_RS21230	COG4682	membrane
CAI18_RS21235	COG2133	pyrroloquinoline quinone binding
CAI18_RS21245	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CAI18_RS21250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CAI18_RS21260	COG1610	YqeY-like protein
CAI18_RS21265	COG1295	ribonuclease BN
CAI18_RS21270	COG0358	DNA primase activity
CAI18_RS21285	COG0109	protoheme IX farnesyltransferase activity
CAI18_RS21315	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CAI18_RS21330	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAI18_RS21370	COG3135	benzoate transporter
CAI18_RS21390	COG0676	glucose-6-phosphate 1-epimerase activity
CAI18_RS21400	COG3012	SEC-C Motif Domain Protein
CAI18_RS21405	COG0730	response to heat
CAI18_RS21430	COG0302	gtp cyclohydrolase
CAI18_RS21445	COG1566	PFAM secretion protein HlyD family protein
CAI18_RS21455	COG1289	transmembrane transporter activity
CAI18_RS21460	COG0477	Major facilitator Superfamily
CAI18_RS21470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI18_RS21490	COG4691	Plasmid stability protein
CAI18_RS21495	COG1487	ribonuclease activity
CAI18_RS21520	COG1028	Short-chain dehydrogenase reductase Sdr
CAI18_RS21530	COG1309	transcriptional regulator
CAI18_RS21565	COG0564	pseudouridine synthase activity
CAI18_RS21640	COG3039	Transposase
CAI18_RS21665	COG1074	ATP-dependent DNA helicase activity
CAI18_RS21670	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CAI18_RS21685	COG1127	ABC transporter
CAI18_RS21690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAI18_RS21695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAI18_RS21710	COG2853	Lipoprotein
CAI18_RS21720	COG0386	Belongs to the glutathione peroxidase family
CAI18_RS21730	COG1322	Protein conserved in bacteria
CAI18_RS21735	COG0604	alcohol dehydrogenase
CAI18_RS21740	COG0583	DNA-binding transcription factor activity
CAI18_RS21750	COG0625	glutathione transferase activity
CAI18_RS21760	COG0531	amino acid
CAI18_RS21805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CAI18_RS21810	COG0861	Integral membrane protein TerC family
CAI18_RS21820	COG0584	glycerophosphoryl diester phosphodiesterase
CAI18_RS21835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CAI18_RS21840	COG0726	polysaccharide deacetylase
CAI18_RS21845	COG0706	membrane insertase activity
CAI18_RS21850	COG0594	ribonuclease P activity
CAI18_RS21860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CAI18_RS21905	COG3012	SEC-C Motif Domain Protein
CAI18_RS21905	COG3318	Belongs to the UPF0149 family
CAI18_RS21915	COG1487	ribonuclease activity
CAI18_RS21920	COG4691	Plasmid stability protein
CAI18_RS22105	COG2948	multi-organism process
CAI18_RS22110	COG3504	Conjugal transfer protein
CAI18_RS22120	COG3704	protein secretion by the type IV secretion system
CAI18_RS22210	COG1192	Involved in chromosome partitioning
CAI18_RS22300	COG3318	Belongs to the UPF0149 family
CAI18_RS22300	COG3012	SEC-C Motif Domain Protein
CAI18_RS22415	COG1192	Involved in chromosome partitioning
CAI18_RS22505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain