locus-tag	class	description
XapA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XapA_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XapA_RS00020	COG0187	DNA topoisomerase II activity
XapA_RS00030	COG0501	Belongs to the peptidase M48B family
XapA_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XapA_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapA_RS00125	COG0793	Belongs to the peptidase S41A family
XapA_RS00130	COG4942	peptidase
XapA_RS00140	COG2234	aminopeptidase activity
XapA_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapA_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapA_RS00170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapA_RS00180	COG1064	alcohol dehydrogenase
XapA_RS00185	COG0493	'glutamate synthase
XapA_RS00190	COG0069	glutamate synthase activity
XapA_RS00190	COG0070	glutamate synthase
XapA_RS00190	COG0067	glutamate synthase
XapA_RS00240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
XapA_RS00270	COG0297	glycogen (starch) synthase activity
XapA_RS00270	COG0438	transferase activity, transferring glycosyl groups
XapA_RS00320	COG1132	(ABC) transporter
XapA_RS00350	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XapA_RS00450	COG1111	helicase
XapA_RS00450	COG1205	dead DEAH box helicase
XapA_RS00455	COG1272	protein, Hemolysin III
XapA_RS00475	COG0300	oxidoreductase activity
XapA_RS00480	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS00495	COG2249	NAD(P)H dehydrogenase (quinone) activity
XapA_RS00510	COG1487	ribonuclease activity
XapA_RS00515	COG4691	Plasmid stability protein
XapA_RS00535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapA_RS00545	COG0477	Major facilitator Superfamily
XapA_RS00550	COG1289	transmembrane transporter activity
XapA_RS00560	COG1566	PFAM secretion protein HlyD family protein
XapA_RS00575	COG0302	gtp cyclohydrolase
XapA_RS00595	COG0730	response to heat
XapA_RS00600	COG3012	SEC-C Motif Domain Protein
XapA_RS00610	COG0676	glucose-6-phosphate 1-epimerase activity
XapA_RS00635	COG3135	benzoate transporter
XapA_RS00665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XapA_RS00685	COG0210	DNA helicase
XapA_RS00700	COG3132	Protein of unknown function, DUF480
XapA_RS00710	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XapA_RS00715	COG0284	orotidine-5'-phosphate decarboxylase activity
XapA_RS00750	COG2937	Belongs to the GPAT DAPAT family
XapA_RS00785	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XapA_RS00870	COG0366	Alpha amylase catalytic
XapA_RS00875	COG0366	Alpha amylase catalytic
XapA_RS00880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XapA_RS00900	COG0657	acetylesterase activity
XapA_RS00900	COG2755	lipolytic protein G-D-S-L family
XapA_RS00910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XapA_RS00925	COG3507	Belongs to the glycosyl hydrolase 43 family
XapA_RS00930	COG1609	Transcriptional regulator
XapA_RS00940	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XapA_RS00945	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS00955	COG2755	lipolytic protein G-D-S-L family
XapA_RS00970	COG3186	Phenylalanine-4-hydroxylase
XapA_RS00975	COG1522	sequence-specific DNA binding
XapA_RS00985	COG1752	Esterase of the alpha-beta hydrolase superfamily
XapA_RS00995	COG1119	ATPase activity
XapA_RS01010	COG1125	glycine betaine transport
XapA_RS01025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XapA_RS01080	COG0489	protein tyrosine kinase activity
XapA_RS01085	COG2062	phosphohistidine phosphatase, SixA
XapA_RS01095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapA_RS01145	COG1968	undecaprenyl-diphosphatase activity
XapA_RS01155	COG0174	glutamine synthetase
XapA_RS01160	COG0347	Belongs to the P(II) protein family
XapA_RS01165	COG0004	ammonium transporteR
XapA_RS01170	COG3852	Histidine kinase
XapA_RS01175	COG2204	response regulator
XapA_RS01180	COG2032	superoxide dismutase activity
XapA_RS01185	COG2032	superoxide dismutase activity
XapA_RS01200	COG0183	Belongs to the thiolase family
XapA_RS01235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XapA_RS01240	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XapA_RS01245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XapA_RS01300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XapA_RS01305	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XapA_RS01310	COG4786	Flagellar basal body rod
XapA_RS01315	COG4786	Flagellar basal body rod
XapA_RS01330	COG1706	bacterial-type flagellum-dependent cell motility
XapA_RS01345	COG1677	Flagellar hook-basal body complex protein FliE
XapA_RS01350	COG1766	The M ring may be actively involved in energy transduction
XapA_RS01365	COG1157	protein secretion by the type III secretion system
XapA_RS01390	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XapA_RS01425	COG0028	Belongs to the TPP enzyme family
XapA_RS01430	COG2205	protein histidine kinase activity
XapA_RS01455	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XapA_RS01470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XapA_RS01480	COG0596	Alpha beta hydrolase
XapA_RS01485	COG0727	PFAM Uncharacterised protein family (UPF0153)
XapA_RS01490	COG0318	PFAM AMP-dependent synthetase and ligase
XapA_RS01495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XapA_RS01510	COG1181	Belongs to the D-alanine--D-alanine ligase family
XapA_RS01520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XapA_RS01530	COG0564	pseudouridine synthase activity
XapA_RS01550	COG1446	asparaginase
XapA_RS01555	COG0339	signal peptide processing
XapA_RS01585	COG0475	glutathione-regulated potassium exporter activity
XapA_RS01590	COG0583	DNA-binding transcription factor activity
XapA_RS01595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XapA_RS01600	COG2224	Isocitrate lyase
XapA_RS01605	COG3706	GGDEF domain
XapA_RS01640	COG4770	biotin carboxylase activity
XapA_RS01645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XapA_RS01650	COG1960	acyl-CoA dehydrogenase activity
XapA_RS01655	COG1309	transcriptional regulator
XapA_RS01710	COG0523	cobalamin synthesis protein
XapA_RS01730	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XapA_RS01735	COG1846	Transcriptional regulator
XapA_RS01740	COG1764	response to oxidative stress
XapA_RS01770	COG2130	NADP-dependent
XapA_RS01785	COG1187	pseudouridine synthase activity
XapA_RS01800	COG1643	Atp-dependent helicase
XapA_RS01805	COG4807	Protein conserved in bacteria
XapA_RS01810	COG2351	hydroxyisourate hydrolase activity
XapA_RS01815	COG2072	flavoprotein involved in K transport
XapA_RS01835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XapA_RS01870	COG1957	nucleoside hydrolase
XapA_RS01880	COG2252	PERMEase
XapA_RS01905	COG0084	hydrolase, TatD family'
XapA_RS01925	COG0583	DNA-binding transcription factor activity
XapA_RS01930	COG2814	Major facilitator Superfamily
XapA_RS01945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XapA_RS01950	COG1902	pentaerythritol trinitrate reductase activity
XapA_RS01970	COG0745	RESPONSE REGULATOR receiver
XapA_RS01975	COG2205	protein histidine kinase activity
XapA_RS01980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_RS02005	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XapA_RS02010	COG0583	DNA-binding transcription factor activity
XapA_RS02045	COG0702	epimerase
XapA_RS02050	COG1733	regulation of RNA biosynthetic process
XapA_RS02095	COG0129	dihydroxy-acid dehydratase activity
XapA_RS02110	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XapA_RS02170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XapA_RS02175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XapA_RS02205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XapA_RS02210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XapA_RS02220	COG3485	protocatechuate 3,4-dioxygenase
XapA_RS02235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XapA_RS02240	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XapA_RS02250	COG1414	Transcriptional regulator
XapA_RS02270	COG0445	tRNA wobble uridine modification
XapA_RS02310	COG2267	carboxylic ester hydrolase activity
XapA_RS02320	COG0156	8-amino-7-oxononanoate synthase activity
XapA_RS02325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XapA_RS02330	COG1040	competence protein
XapA_RS02335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XapA_RS02430	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XapA_RS02500	COG1511	domain protein
XapA_RS02500	COG3264	Mechanosensitive ion channel
XapA_RS02505	COG1368	sulfuric ester hydrolase activity
XapA_RS02515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XapA_RS02520	COG2354	Protein conserved in bacteria
XapA_RS02530	COG0297	glycogen (starch) synthase activity
XapA_RS02535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XapA_RS02540	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XapA_RS02565	COG0702	epimerase
XapA_RS02570	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS02605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapA_RS02610	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS02625	COG0513	Belongs to the DEAD box helicase family
XapA_RS02645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XapA_RS02660	COG3483	tryptophan 2,3-dioxygenase activity
XapA_RS02665	COG3104	oligopeptide transport
XapA_RS02690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XapA_RS02710	COG1320	monovalent cation:proton antiporter activity
XapA_RS02715	COG2212	antiporter activity
XapA_RS02725	COG0651	ATP synthesis coupled electron transport
XapA_RS02730	COG1006	Multisubunit Na H antiporter MnhC subunit
XapA_RS02735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XapA_RS02735	COG2111	Na H antiporter
XapA_RS02760	COG3179	chitinase
XapA_RS02780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XapA_RS02785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XapA_RS02800	COG0456	acetyltransferase
XapA_RS02805	COG1597	lipid kinase activity
XapA_RS02830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XapA_RS02835	COG0134	indole-3-glycerol-phosphate synthase activity
XapA_RS02845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XapA_RS02850	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XapA_RS02860	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XapA_RS02870	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XapA_RS02885	COG1051	belongs to the nudix hydrolase family
XapA_RS02925	COG0316	Belongs to the HesB IscA family
XapA_RS02945	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XapA_RS02960	COG2814	Major facilitator Superfamily
XapA_RS02970	COG2814	Major facilitator Superfamily
XapA_RS02975	COG1289	transmembrane transporter activity
XapA_RS02985	COG0151	Belongs to the GarS family
XapA_RS02995	COG0138	bifunctional purine biosynthesis protein purh
XapA_RS03000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XapA_RS03005	COG2267	carboxylic ester hydrolase activity
XapA_RS03010	COG2453	phosphatase
XapA_RS03010	COG0671	phosphoesterase, PA-phosphatase related
XapA_RS03035	COG4589	Belongs to the CDS family
XapA_RS03040	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XapA_RS03065	COG2264	protein methyltransferase activity
XapA_RS03085	COG0439	Biotin carboxylase
XapA_RS03095	COG0511	ligase activity, forming carbon-carbon bonds
XapA_RS03100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XapA_RS03110	COG1324	tolerance protein
XapA_RS03140	COG0300	oxidoreductase activity
XapA_RS03150	COG2356	endonuclease I
XapA_RS03160	COG0459	protein refolding
XapA_RS03175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XapA_RS03190	COG3386	PFAM SMP-30 Gluconolaconase
XapA_RS03200	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XapA_RS03205	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XapA_RS03225	COG0778	Nitroreductase
XapA_RS03230	COG2353	YceI-like domain
XapA_RS03260	COG3052	prosthetic group binding
XapA_RS03295	COG1802	Transcriptional regulator
XapA_RS03375	COG4221	oxidoreductase activity
XapA_RS03390	COG4221	oxidoreductase activity
XapA_RS03400	COG0435	Glutathione S-transferase
XapA_RS03425	COG2409	Drug exporters of the RND superfamily
XapA_RS03435	COG0823	Involved in the tonB-independent uptake of proteins
XapA_RS03435	COG1506	peptidase
XapA_RS03455	COG3706	GGDEF domain
XapA_RS03480	COG0697	spore germination
XapA_RS03495	COG1113	amino acid transport
XapA_RS03515	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XapA_RS03565	COG5001	Diguanylate cyclase
XapA_RS03575	COG0840	transmembrane signaling receptor activity
XapA_RS03580	COG5297	Belongs to the glycosyl hydrolase family 6
XapA_RS03580	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapA_RS03585	COG0659	secondary active sulfate transmembrane transporter activity
XapA_RS03595	COG3706	GGDEF domain
XapA_RS03615	COG2943	transferase activity, transferring hexosyl groups
XapA_RS03625	COG3275	phosphorelay sensor kinase activity
XapA_RS03635	COG0181	hydroxymethylbilane synthase activity
XapA_RS03675	COG1505	serine-type exopeptidase activity
XapA_RS03695	COG2832	Protein of unknown function (DUF454)
XapA_RS03705	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XapA_RS03715	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XapA_RS03720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XapA_RS03725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XapA_RS03750	COG2226	methyltransferase
XapA_RS03755	COG2199	diguanylate cyclase activity
XapA_RS03760	COG0308	aminopeptidase N
XapA_RS03795	COG1162	GTPase activity
XapA_RS03820	COG2211	Major facilitator Superfamily
XapA_RS03825	COG1609	Transcriptional regulator
XapA_RS03830	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS03835	COG2851	Citrate transporter
XapA_RS03855	COG0642	Histidine kinase
XapA_RS03870	COG2197	response regulator
XapA_RS03890	COG0667	Aldo Keto reductase
XapA_RS03900	COG0583	DNA-binding transcription factor activity
XapA_RS03930	COG1301	dicarboxylic acid transport
XapA_RS03935	COG0280	phosphate acetyltransferase
XapA_RS03935	COG0281	malic enzyme
XapA_RS03960	COG1560	Kdo2-lipid A biosynthetic process
XapA_RS03965	COG1519	Transferase
XapA_RS03970	COG1538	Outer membrane efflux protein
XapA_RS03975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XapA_RS03995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XapA_RS04000	COG0066	3-isopropylmalate dehydratase activity
XapA_RS04005	COG0473	3-isopropylmalate dehydrogenase activity
XapA_RS04010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XapA_RS04030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XapA_RS04040	COG0840	transmembrane signaling receptor activity
XapA_RS04055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XapA_RS04060	COG3710	Transcriptional regulator
XapA_RS04090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XapA_RS04100	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XapA_RS04125	COG0563	adenylate kinase activity
XapA_RS04130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XapA_RS04140	COG3781	membrane
XapA_RS04145	COG0671	phosphoesterase, PA-phosphatase related
XapA_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS04165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XapA_RS04170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XapA_RS04200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XapA_RS04215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XapA_RS04230	COG0352	thiamine-phosphate diphosphorylase activity
XapA_RS04235	COG1773	rubredoxin
XapA_RS04240	COG2912	Transglutaminase-like superfamily
XapA_RS04250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XapA_RS04260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XapA_RS04280	COG3079	Belongs to the UPF0149 family
XapA_RS04285	COG0006	proline dipeptidase activity
XapA_RS04295	COG0006	proline dipeptidase activity
XapA_RS04310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XapA_RS04315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XapA_RS04325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XapA_RS04330	COG1561	YicC-like family, N-terminal region
XapA_RS04335	COG0194	GDP metabolic process
XapA_RS04345	COG1070	Carbohydrate kinase
XapA_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS04370	COG3659	wide pore channel activity
XapA_RS04385	COG2390	Transcriptional regulator
XapA_RS04390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XapA_RS04395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XapA_RS04405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XapA_RS04435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XapA_RS04465	COG0714	Associated with various cellular activities
XapA_RS04485	COG2304	oxidoreductase activity
XapA_RS04495	COG1301	dicarboxylic acid transport
XapA_RS04500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XapA_RS04505	COG0596	Alpha beta hydrolase
XapA_RS04510	COG4773	Receptor
XapA_RS04520	COG0739	heme binding
XapA_RS04530	COG1376	ErfK ybiS ycfS ynhG family protein
XapA_RS04565	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XapA_RS04570	COG4149	molybdate abc transporter
XapA_RS04575	COG0725	ABC transporter, periplasmic molybdate-binding protein
XapA_RS04580	COG3453	Protein conserved in bacteria
XapA_RS04580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XapA_RS04590	COG3047	cAMP biosynthetic process
XapA_RS04595	COG3047	cAMP biosynthetic process
XapA_RS04610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XapA_RS04635	COG0126	phosphoglycerate kinase activity
XapA_RS04645	COG0469	pyruvate kinase activity
XapA_RS04650	COG3588	fructose-bisphosphate aldolase
XapA_RS04655	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XapA_RS04670	COG1648	precorrin-2 dehydrogenase activity
XapA_RS04670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XapA_RS04690	COG0784	Response regulator, receiver
XapA_RS04690	COG2205	protein histidine kinase activity
XapA_RS04690	COG2198	Histidine kinase
XapA_RS04710	COG0175	sulfate reduction
XapA_RS04715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XapA_RS04720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XapA_RS04725	COG0175	sulfate reduction
XapA_RS04730	COG0529	Catalyzes the synthesis of activated sulfate
XapA_RS04730	COG2895	sulfate adenylyltransferase (ATP) activity
XapA_RS04735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_RS04740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapA_RS04790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XapA_RS04805	COG4948	Mandelate Racemase Muconate Lactonizing
XapA_RS04810	COG3250	beta-galactosidase activity
XapA_RS04820	COG1609	Transcriptional regulator
XapA_RS04830	COG1970	mechanosensitive ion channel activity
XapA_RS04855	COG3273	potassium ion transport
XapA_RS04855	COG0471	metal ion transport
XapA_RS04860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XapA_RS04870	COG2022	thiamine diphosphate biosynthetic process
XapA_RS04915	COG0189	ligase activity
XapA_RS04925	COG0745	RESPONSE REGULATOR receiver
XapA_RS04930	COG5002	protein histidine kinase activity
XapA_RS05045	COG2010	Cytochrome c
XapA_RS05065	COG3284	Transcriptional regulator
XapA_RS05070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XapA_RS05075	COG1077	Cell shape determining protein MreB Mrl
XapA_RS05080	COG1792	Involved in formation and maintenance of cell shape
XapA_RS05095	COG0772	Belongs to the SEDS family
XapA_RS05105	COG2951	lytic endotransglycosylase activity
XapA_RS05110	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XapA_RS05120	COG1686	Belongs to the peptidase S11 family
XapA_RS05130	COG2921	Belongs to the UPF0250 family
XapA_RS05135	COG0321	lipoyl(octanoyl) transferase activity
XapA_RS05140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XapA_RS05155	COG0583	DNA-binding transcription factor activity
XapA_RS05165	COG1056	cytidyltransferase-related domain
XapA_RS05165	COG1051	belongs to the nudix hydrolase family
XapA_RS05200	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XapA_RS05205	COG0673	inositol 2-dehydrogenase activity
XapA_RS05210	COG2823	Periplasmic or secreted lipoprotein
XapA_RS05215	COG4251	negative regulation of phosphorylation
XapA_RS05220	COG0784	Response regulator, receiver
XapA_RS05225	COG4191	Histidine kinase
XapA_RS05230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XapA_RS05290	COG1459	type II secretion system
XapA_RS05310	COG4795	General secretion pathway protein
XapA_RS05340	COG3250	beta-galactosidase activity
XapA_RS05355	COG2188	Transcriptional regulator
XapA_RS05365	COG1609	Transcriptional regulator
XapA_RS05370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XapA_RS05375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XapA_RS05385	COG0617	tRNA 3'-terminal CCA addition
XapA_RS05390	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XapA_RS05395	COG1012	belongs to the aldehyde dehydrogenase family
XapA_RS05400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XapA_RS05415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XapA_RS05430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XapA_RS05435	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XapA_RS05455	COG2205	protein histidine kinase activity
XapA_RS05460	COG0745	RESPONSE REGULATOR receiver
XapA_RS05485	COG3791	Glutathione-dependent formaldehyde-activating
XapA_RS05500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XapA_RS05510	COG0697	spore germination
XapA_RS05520	COG0488	(ABC) transporter
XapA_RS05530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XapA_RS05535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XapA_RS05545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XapA_RS05545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XapA_RS05565	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XapA_RS05570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XapA_RS05575	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XapA_RS05600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XapA_RS05605	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XapA_RS05610	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XapA_RS05615	COG2205	protein histidine kinase activity
XapA_RS05620	COG0745	RESPONSE REGULATOR receiver
XapA_RS05660	COG0277	FAD linked oxidase domain protein
XapA_RS05665	COG1988	membrane-bound metal-dependent
XapA_RS05670	COG0792	nuclease activity
XapA_RS05710	COG0275	rRNA processing
XapA_RS05715	COG3116	cell division
XapA_RS05725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XapA_RS05730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XapA_RS05735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XapA_RS05745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XapA_RS05750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XapA_RS05755	COG1181	Belongs to the D-alanine--D-alanine ligase family
XapA_RS05760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XapA_RS05775	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XapA_RS05790	COG0653	protein targeting
XapA_RS05795	COG0494	nUDIX hydrolase
XapA_RS05805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XapA_RS05820	COG3321	synthase
XapA_RS05820	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS05820	COG0604	alcohol dehydrogenase
XapA_RS05855	COG0366	Alpha amylase catalytic
XapA_RS05890	COG2226	methyltransferase
XapA_RS05895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XapA_RS05905	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XapA_RS05955	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XapA_RS05965	COG4106	trans-aconitate 2-methyltransferase activity
XapA_RS05970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XapA_RS05980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XapA_RS05985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XapA_RS05995	COG0667	Aldo Keto reductase
XapA_RS06005	COG4771	TonB-dependent receptor
XapA_RS06025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XapA_RS06030	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XapA_RS06040	COG2175	clavaminate synthase activity
XapA_RS06050	COG4181	ATPase activity
XapA_RS06065	COG0642	Histidine kinase
XapA_RS06085	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XapA_RS06100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapA_RS06105	COG2201	protein-glutamate methylesterase activity
XapA_RS06110	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XapA_RS06115	COG2199	diguanylate cyclase activity
XapA_RS06115	COG2200	EAL domain
XapA_RS06115	COG2202	Pas domain
XapA_RS06120	COG0835	chemotaxis
XapA_RS06125	COG0840	transmembrane signaling receptor activity
XapA_RS06130	COG2198	Histidine kinase
XapA_RS06130	COG0643	Histidine kinase
XapA_RS06140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XapA_RS06150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XapA_RS06160	COG2205	protein histidine kinase activity
XapA_RS06165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XapA_RS06175	COG4452	Inner membrane protein CreD
XapA_RS06200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XapA_RS06205	COG0735	belongs to the Fur family
XapA_RS06220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapA_RS06240	COG2207	Transcriptional regulator
XapA_RS06250	COG0583	DNA-binding transcription factor activity
XapA_RS06255	COG2814	Major facilitator Superfamily
XapA_RS06340	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XapA_RS06390	COG5002	protein histidine kinase activity
XapA_RS06390	COG5001	Diguanylate cyclase
XapA_RS06395	COG1187	pseudouridine synthase activity
XapA_RS06420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XapA_RS06430	COG0475	glutathione-regulated potassium exporter activity
XapA_RS06435	COG5000	phosphorelay sensor kinase activity
XapA_RS06435	COG5002	protein histidine kinase activity
XapA_RS06440	COG0745	RESPONSE REGULATOR receiver
XapA_RS06445	COG1538	Outer membrane efflux protein
XapA_RS06475	COG1132	(ABC) transporter
XapA_RS06520	COG2155	Conserved Protein
XapA_RS06555	COG3118	belongs to the thioredoxin family
XapA_RS06565	COG0495	leucyl-tRNA aminoacylation
XapA_RS06580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XapA_RS06595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XapA_RS06615	COG2968	Membrane
XapA_RS06620	COG0424	maF-like protein
XapA_RS06625	COG1530	ribonuclease E activity
XapA_RS06630	COG3164	Protein of unknown function
XapA_RS06640	COG0312	modulator of DNA gyrase
XapA_RS06645	COG3028	Belongs to the UPF0307 family
XapA_RS06650	COG0312	modulator of DNA gyrase
XapA_RS06665	COG3318	Belongs to the UPF0149 family
XapA_RS06665	COG3012	SEC-C Motif Domain Protein
XapA_RS06685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapA_RS06695	COG0142	geranyltranstransferase activity
XapA_RS06700	COG1722	exodeoxyribonuclease VII activity
XapA_RS06705	COG0037	tRNA processing
XapA_RS06715	COG1785	Belongs to the alkaline phosphatase family
XapA_RS06720	COG1301	dicarboxylic acid transport
XapA_RS06725	COG4106	trans-aconitate 2-methyltransferase activity
XapA_RS06735	COG0791	NLP P60 protein
XapA_RS06740	COG0791	NLP P60 protein
XapA_RS06745	COG1047	Peptidyl-prolyl cis-trans
XapA_RS06750	COG2311	Membrane
XapA_RS06755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapA_RS06760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XapA_RS06785	COG3590	peptidase
XapA_RS06795	COG3590	peptidase
XapA_RS06860	COG3209	COG3209 Rhs family protein
XapA_RS06915	COG3250	beta-galactosidase activity
XapA_RS06920	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XapA_RS06940	COG1960	acyl-CoA dehydrogenase activity
XapA_RS06945	COG1024	Enoyl-CoA hydratase
XapA_RS06980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XapA_RS06985	COG0481	GTPase activity
XapA_RS07000	COG0571	ribonuclease III activity
XapA_RS07005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XapA_RS07020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XapA_RS07030	COG2954	triphosphatase activity
XapA_RS07035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XapA_RS07040	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
XapA_RS07045	COG3046	protein related to deoxyribodipyrimidine photolyase
XapA_RS07050	COG1472	Belongs to the glycosyl hydrolase 3 family
XapA_RS07060	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XapA_RS07070	COG1278	Cold shock
XapA_RS07085	COG1201	RNA secondary structure unwinding
XapA_RS07090	COG1793	dna ligase
XapA_RS07100	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XapA_RS07100	COG1793	dna ligase
XapA_RS07135	COG0183	Belongs to the thiolase family
XapA_RS07160	COG1451	nucleotide metabolic process
XapA_RS07165	COG5487	UPF0391 membrane protein
XapA_RS07175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XapA_RS07195	COG1047	Peptidyl-prolyl cis-trans
XapA_RS07205	COG2824	Alkylphosphonate utilization operon protein PhnA
XapA_RS07220	COG2814	Major facilitator Superfamily
XapA_RS07250	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XapA_RS07250	COG0392	lysyltransferase activity
XapA_RS07260	COG0251	oxidation-reduction process
XapA_RS07265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XapA_RS07280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XapA_RS07305	COG1595	DNA-templated transcription, initiation
XapA_RS07325	COG2878	Part of a membrane complex involved in electron transport
XapA_RS07335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XapA_RS07335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XapA_RS07350	COG1131	(ABC) transporter
XapA_RS07355	COG0346	lactoylglutathione lyase activity
XapA_RS07360	COG0833	amino acid
XapA_RS07365	COG2040	homocysteine
XapA_RS07375	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XapA_RS07395	COG1695	Transcriptional regulator
XapA_RS07430	COG0825	malonyl-CoA metabolic process
XapA_RS07440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XapA_RS07445	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XapA_RS07450	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XapA_RS07455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XapA_RS07460	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XapA_RS07475	COG0750	zinc metalloprotease
XapA_RS07480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XapA_RS07485	COG0575	Belongs to the CDS family
XapA_RS07490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XapA_RS07495	COG0233	cytoplasmic translational termination
XapA_RS07500	COG0528	UMP kinase activity
XapA_RS07510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XapA_RS07515	COG0052	Belongs to the universal ribosomal protein uS2 family
XapA_RS07555	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XapA_RS07565	COG1393	Belongs to the ArsC family
XapA_RS07570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XapA_RS07575	COG0367	asparagine synthase
XapA_RS07585	COG4774	siderophore transport
XapA_RS07630	COG1566	PFAM secretion protein HlyD family protein
XapA_RS07635	COG2814	Major facilitator Superfamily
XapA_RS07660	COG3104	oligopeptide transport
XapA_RS07690	COG0339	signal peptide processing
XapA_RS07700	COG0386	Belongs to the glutathione peroxidase family
XapA_RS07760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XapA_RS07765	COG0084	hydrolase, TatD family'
XapA_RS07780	COG1960	acyl-CoA dehydrogenase activity
XapA_RS07800	COG0367	asparagine synthase
XapA_RS07810	COG0305	Participates in initiation and elongation during chromosome replication
XapA_RS07815	COG0415	Belongs to the DNA photolyase family
XapA_RS07835	COG0583	DNA-binding transcription factor activity
XapA_RS07870	COG3706	GGDEF domain
XapA_RS07880	COG3706	GGDEF domain
XapA_RS07910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XapA_RS07925	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XapA_RS07935	COG0497	DNA recombination
XapA_RS07940	COG1420	regulation of RNA biosynthetic process
XapA_RS07945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XapA_RS07950	COG0443	Heat shock 70 kDa protein
XapA_RS07955	COG0484	heat shock protein binding
XapA_RS07995	COG0583	DNA-binding transcription factor activity
XapA_RS08000	COG1132	(ABC) transporter
XapA_RS08035	COG2850	peptidyl-arginine hydroxylation
XapA_RS08055	COG1253	flavin adenine dinucleotide binding
XapA_RS08085	COG1131	(ABC) transporter
XapA_RS08090	COG1725	Transcriptional regulator
XapA_RS08100	COG0386	Belongs to the glutathione peroxidase family
XapA_RS08115	COG2900	Belongs to the SlyX family
XapA_RS08140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XapA_RS08165	COG0646	methionine synthase
XapA_RS08165	COG1410	methionine synthase
XapA_RS08170	COG2226	methyltransferase
XapA_RS08175	COG1960	acyl-CoA dehydrogenase activity
XapA_RS08180	COG1960	acyl-CoA dehydrogenase activity
XapA_RS08200	COG0557	exoribonuclease II activity
XapA_RS08210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XapA_RS08215	COG3706	GGDEF domain
XapA_RS08220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XapA_RS08230	COG0704	Plays a role in the regulation of phosphate uptake
XapA_RS08235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XapA_RS08240	COG0581	inorganic phosphate transmembrane transporter activity
XapA_RS08245	COG0573	inorganic phosphate transmembrane transporter activity
XapA_RS08250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XapA_RS08275	COG0659	secondary active sulfate transmembrane transporter activity
XapA_RS08280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XapA_RS08290	COG1024	Enoyl-CoA hydratase
XapA_RS08300	COG0494	nUDIX hydrolase
XapA_RS08350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XapA_RS08375	COG2925	Exonuclease
XapA_RS08385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XapA_RS08390	COG3844	kynureninase activity
XapA_RS08400	COG0662	Cupin 2, conserved barrel domain protein
XapA_RS08405	COG0288	reversible hydration of carbon dioxide
XapA_RS08470	COG2808	Putative FMN-binding domain
XapA_RS08490	COG0017	Asparaginyl-tRNA synthetase
XapA_RS08500	COG0316	Belongs to the HesB IscA family
XapA_RS08505	COG0360	Binds together with S18 to 16S ribosomal RNA
XapA_RS08510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XapA_RS08515	COG0359	binds to the 23S rRNA
XapA_RS08525	COG3115	cell septum assembly
XapA_RS08535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XapA_RS08540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XapA_RS08545	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XapA_RS08560	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XapA_RS08570	COG4993	Dehydrogenase
XapA_RS08580	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XapA_RS08590	COG2986	histidine ammonia-lyase
XapA_RS08595	COG1228	amidohydrolase
XapA_RS08635	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XapA_RS08640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XapA_RS08645	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XapA_RS08650	COG1605	Chorismate mutase
XapA_RS08650	COG0077	Prephenate dehydratase
XapA_RS08655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XapA_RS08670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XapA_RS08675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XapA_RS08680	COG0583	DNA-binding transcription factor activity
XapA_RS08705	COG0840	transmembrane signaling receptor activity
XapA_RS08740	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XapA_RS08745	COG4191	Histidine kinase
XapA_RS08745	COG0784	Response regulator, receiver
XapA_RS08760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XapA_RS08770	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XapA_RS08780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XapA_RS08795	COG1595	DNA-templated transcription, initiation
XapA_RS08850	COG2244	polysaccharide biosynthetic process
XapA_RS08885	COG2264	protein methyltransferase activity
XapA_RS08910	COG1136	(ABC) transporter
XapA_RS08915	COG1132	(ABC) transporter
XapA_RS08920	COG0477	Major facilitator Superfamily
XapA_RS08925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XapA_RS08940	COG1253	flavin adenine dinucleotide binding
XapA_RS08955	COG0306	phosphate transporter
XapA_RS08980	COG0504	CTP synthase activity
XapA_RS08985	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XapA_RS08995	COG0148	phosphopyruvate hydratase activity
XapA_RS09000	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XapA_RS09005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XapA_RS09010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XapA_RS09015	COG0585	pseudouridine synthase activity
XapA_RS09020	COG2840	Smr protein MutS2
XapA_RS09025	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XapA_RS09030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XapA_RS09035	COG1238	metal cluster binding
XapA_RS09050	COG1534	Rna-binding protein
XapA_RS09055	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XapA_RS09065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XapA_RS09070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XapA_RS09080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XapA_RS09085	COG1546	Belongs to the CinA family
XapA_RS09095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XapA_RS09100	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XapA_RS09110	COG2137	regulation of response to DNA damage stimulus
XapA_RS09115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XapA_RS09120	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XapA_RS09140	COG1741	Belongs to the pirin family
XapA_RS09145	COG0583	DNA-binding transcription factor activity
XapA_RS09170	COG0351	phosphomethylpyrimidine kinase
XapA_RS09185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XapA_RS09190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XapA_RS09205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XapA_RS09215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XapA_RS09220	COG3734	2-keto-3-deoxy-galactonokinase
XapA_RS09230	COG4948	Mandelate Racemase Muconate Lactonizing
XapA_RS09235	COG0800	Aldolase
XapA_RS09275	COG1501	Belongs to the glycosyl hydrolase 31 family
XapA_RS09285	COG1070	Carbohydrate kinase
XapA_RS09290	COG2115	Belongs to the xylose isomerase family
XapA_RS09295	COG0477	Major facilitator Superfamily
XapA_RS09315	COG0860	N-Acetylmuramoyl-L-alanine amidase
XapA_RS09320	COG1469	GTP cyclohydrolase I activity
XapA_RS09340	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XapA_RS09345	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XapA_RS09350	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XapA_RS09355	COG0166	Belongs to the GPI family
XapA_RS09380	COG1472	Belongs to the glycosyl hydrolase 3 family
XapA_RS09395	COG3706	GGDEF domain
XapA_RS09395	COG2203	Gaf domain
XapA_RS09395	COG5001	Diguanylate cyclase
XapA_RS09395	COG4251	negative regulation of phosphorylation
XapA_RS09400	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapA_RS09405	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XapA_RS09420	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XapA_RS09425	COG0671	phosphoesterase, PA-phosphatase related
XapA_RS09455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XapA_RS09460	COG0167	dihydroorotate dehydrogenase activity
XapA_RS09480	COG1012	belongs to the aldehyde dehydrogenase family
XapA_RS09510	COG0326	Molecular chaperone. Has ATPase activity
XapA_RS09515	COG0742	ribosomal rna small subunit methyltransferase
XapA_RS09520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XapA_RS09535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XapA_RS09540	COG0405	Gamma-glutamyltransferase
XapA_RS09545	COG3291	Pkd domain containing protein
XapA_RS09550	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XapA_RS09590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XapA_RS09595	COG0343	queuine tRNA-ribosyltransferase activity
XapA_RS09600	COG1862	Preprotein translocase
XapA_RS09610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XapA_RS09650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XapA_RS09650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XapA_RS09655	COG1105	Belongs to the carbohydrate kinase PfkB family
XapA_RS09660	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XapA_RS09660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XapA_RS09665	COG1609	Transcriptional regulator
XapA_RS09675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapA_RS09680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_RS09690	COG2902	Dehydrogenase
XapA_RS09725	COG1238	metal cluster binding
XapA_RS09745	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS09780	COG2226	methyltransferase
XapA_RS09780	COG1073	alpha beta
XapA_RS09880	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XapA_RS09880	COG0316	Belongs to the HesB IscA family
XapA_RS09885	COG2154	pterin-4-alpha-carbinolamine dehydratase
XapA_RS09895	COG0428	transporter
XapA_RS09900	COG3064	Membrane
XapA_RS09910	COG1530	ribonuclease E activity
XapA_RS09940	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XapA_RS09965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XapA_RS10050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XapA_RS10055	COG0322	excinuclease ABC activity
XapA_RS10065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XapA_RS10070	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XapA_RS10075	COG1663	tetraacyldisaccharide 4'-kinase activity
XapA_RS10080	COG1132	(ABC) transporter
XapA_RS10090	COG0811	peptide transport
XapA_RS10105	COG1136	(ABC) transporter
XapA_RS10110	COG4591	ABC-type transport system involved in lipoprotein release permease component
XapA_RS10120	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XapA_RS10140	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XapA_RS10165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XapA_RS10170	COG0837	glucose binding
XapA_RS10175	COG0363	glucosamine-6-phosphate deaminase activity
XapA_RS10180	COG0129	dihydroxy-acid dehydratase activity
XapA_RS10185	COG0800	Aldolase
XapA_RS10255	COG0784	Response regulator, receiver
XapA_RS10255	COG2205	protein histidine kinase activity
XapA_RS10260	COG2183	response to ionizing radiation
XapA_RS10270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapA_RS10270	COG0723	plastoquinol--plastocyanin reductase activity
XapA_RS10285	COG3243	poly(R)-hydroxyalkanoic acid synthase
XapA_RS10295	COG1183	phosphatidylcholine synthase activity
XapA_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS10315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XapA_RS10325	COG0668	transmembrane transport
XapA_RS10345	COG4456	Virulence-associated protein
XapA_RS10410	COG3318	Belongs to the UPF0149 family
XapA_RS10410	COG3012	SEC-C Motif Domain Protein
XapA_RS10430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapA_RS10460	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XapA_RS10475	COG1914	H( )-stimulated, divalent metal cation uptake system
XapA_RS10495	COG2814	Major facilitator Superfamily
XapA_RS10520	COG1335	isochorismatase
XapA_RS10535	COG2197	response regulator
XapA_RS10555	COG0583	DNA-binding transcription factor activity
XapA_RS10560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XapA_RS10565	COG3002	Belongs to the UPF0753 family
XapA_RS10570	COG0519	Catalyzes the synthesis of GMP from XMP
XapA_RS10570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XapA_RS10580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XapA_RS10590	COG0475	glutathione-regulated potassium exporter activity
XapA_RS10590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XapA_RS10600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XapA_RS10610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XapA_RS10615	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XapA_RS10625	COG0776	regulation of translation
XapA_RS10630	COG0539	negative regulation of cytoplasmic translation
XapA_RS10635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XapA_RS10655	COG2957	Belongs to the agmatine deiminase family
XapA_RS10660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XapA_RS10685	COG0395	ABC-type sugar transport system, permease component
XapA_RS10690	COG1175	transmembrane transport
XapA_RS10720	COG2350	Protein conserved in bacteria
XapA_RS10725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XapA_RS10730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XapA_RS10735	COG1187	pseudouridine synthase activity
XapA_RS10755	COG0436	Aminotransferase
XapA_RS10760	COG4133	protoheme IX ABC transporter activity
XapA_RS10780	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XapA_RS10785	COG1138	Cytochrome C-type biogenesis protein
XapA_RS10805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XapA_RS10810	COG1278	Cold shock
XapA_RS10815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XapA_RS10820	COG4988	ABC transporter
XapA_RS10830	COG1294	oxidase, subunit
XapA_RS10840	COG3344	reverse transcriptase
XapA_RS10865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XapA_RS10870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XapA_RS10880	COG0165	Argininosuccinate lyase
XapA_RS10885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XapA_RS10895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XapA_RS10900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XapA_RS10910	COG0137	argininosuccinate synthase activity
XapA_RS10915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XapA_RS10925	COG0215	cysteine-tRNA ligase activity
XapA_RS10930	COG2166	iron-sulfur cluster assembly
XapA_RS10945	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XapA_RS10950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XapA_RS10980	COG4302	ethanolamine ammonia-lyase activity
XapA_RS11050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XapA_RS11055	COG0402	S-adenosylhomocysteine deaminase activity
XapA_RS11065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XapA_RS11070	COG1509	lysine 2,3-aminomutase activity
XapA_RS11075	COG5001	Diguanylate cyclase
XapA_RS11075	COG3300	MHYT domain
XapA_RS11090	COG0483	inositol monophosphate 1-phosphatase activity
XapA_RS11095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XapA_RS11120	COG0513	Belongs to the DEAD box helicase family
XapA_RS11125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XapA_RS11130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XapA_RS11140	COG0625	glutathione transferase activity
XapA_RS11150	COG4681	YaeQ
XapA_RS11155	COG2081	HI0933 family
XapA_RS11190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapA_RS11200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XapA_RS11205	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS11230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XapA_RS11235	COG0860	N-Acetylmuramoyl-L-alanine amidase
XapA_RS11240	COG0802	atpase or kinase
XapA_RS11245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XapA_RS11245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XapA_RS11250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XapA_RS11255	COG1570	exodeoxyribonuclease VII activity
XapA_RS11270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XapA_RS11310	COG0835	chemotaxis
XapA_RS11315	COG0840	transmembrane signaling receptor activity
XapA_RS11320	COG2094	Belongs to the DNA glycosylase MPG family
XapA_RS11325	COG1201	RNA secondary structure unwinding
XapA_RS11345	COG2969	positive regulation of protein catabolic process
XapA_RS11350	COG0625	glutathione transferase activity
XapA_RS11355	COG2857	Cytochrome c1
XapA_RS11360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XapA_RS11375	COG0741	lytic transglycosylase activity
XapA_RS11390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XapA_RS11400	COG1702	phosphate starvation-inducible protein PhoH
XapA_RS11410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XapA_RS11420	COG4535	Mg2 and Co2 transporter CorC
XapA_RS11435	COG1012	belongs to the aldehyde dehydrogenase family
XapA_RS11440	COG1177	transmembrane transport
XapA_RS11445	COG1176	ABC-type spermidine putrescine transport system, permease component I
XapA_RS11450	COG3842	ATPase activity
XapA_RS11470	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XapA_RS11485	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XapA_RS11490	COG0174	glutamine synthetase
XapA_RS11495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapA_RS11505	COG2703	oxygen carrier activity
XapA_RS11520	COG0243	molybdopterin cofactor binding
XapA_RS11525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XapA_RS11530	COG2223	nitrite transmembrane transporter activity
XapA_RS11555	COG2733	membrane
XapA_RS11560	COG0784	Response regulator, receiver
XapA_RS11560	COG2205	protein histidine kinase activity
XapA_RS11560	COG5002	protein histidine kinase activity
XapA_RS11570	COG0477	Major facilitator Superfamily
XapA_RS11600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_RS11620	COG4566	intracellular signal transduction
XapA_RS11650	COG3685	Protein conserved in bacteria
XapA_RS11690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XapA_RS11690	COG1648	precorrin-2 dehydrogenase activity
XapA_RS11700	COG0746	molybdenum cofactor guanylyltransferase activity
XapA_RS11715	COG0708	Exodeoxyribonuclease III
XapA_RS11755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XapA_RS11765	COG0303	'Molybdopterin
XapA_RS11770	COG1160	GTP binding
XapA_RS11775	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XapA_RS11785	COG1426	Protein conserved in bacteria
XapA_RS11795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XapA_RS11810	COG1250	3-hydroxyacyl-CoA dehydrogenase
XapA_RS11810	COG1024	Enoyl-CoA hydratase
XapA_RS11815	COG0183	Belongs to the thiolase family
XapA_RS11825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XapA_RS11830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XapA_RS11840	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XapA_RS11850	COG1674	ftsk spoiiie
XapA_RS11855	COG0492	ferredoxin-NADP+ reductase activity
XapA_RS11865	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XapA_RS11875	COG0542	response to heat
XapA_RS11890	COG0482	sulfurtransferase activity
XapA_RS11895	COG2915	High frequency lysogenization protein hflD homolog
XapA_RS11925	COG5002	protein histidine kinase activity
XapA_RS11945	COG0835	chemotaxis
XapA_RS11945	COG0784	Response regulator, receiver
XapA_RS11955	COG1558	bacterial-type flagellum-dependent cell motility
XapA_RS11960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XapA_RS11975	COG4787	bacterial-type flagellum-dependent cell motility
XapA_RS11990	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XapA_RS11995	COG1706	bacterial-type flagellum-dependent cell motility
XapA_RS12000	COG3951	Flagellar rod assembly protein muramidase FlgJ
XapA_RS12000	COG1705	Flagellar rod assembly protein muramidase FlgJ
XapA_RS12010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XapA_RS12015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XapA_RS12025	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XapA_RS12055	COG2201	protein-glutamate methylesterase activity
XapA_RS12100	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS12105	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS12150	COG1677	Flagellar hook-basal body complex protein FliE
XapA_RS12200	COG3190	flagellar
XapA_RS12220	COG1684	flagellar biosynthetic protein fliR
XapA_RS12225	COG3300	MHYT domain
XapA_RS12225	COG5001	Diguanylate cyclase
XapA_RS12250	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XapA_RS12280	COG2198	Histidine kinase
XapA_RS12280	COG0784	Response regulator, receiver
XapA_RS12280	COG0643	Histidine kinase
XapA_RS12295	COG0641	radical SAM
XapA_RS12330	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XapA_RS12335	COG1360	Flagellar Motor Protein
XapA_RS12345	COG0835	chemotaxis
XapA_RS12355	COG0745	RESPONSE REGULATOR receiver
XapA_RS12360	COG0643	Histidine kinase
XapA_RS12360	COG2198	Histidine kinase
XapA_RS12365	COG0840	transmembrane signaling receptor activity
XapA_RS12380	COG0840	transmembrane signaling receptor activity
XapA_RS12395	COG0840	transmembrane signaling receptor activity
XapA_RS12400	COG0840	transmembrane signaling receptor activity
XapA_RS12410	COG0840	transmembrane signaling receptor activity
XapA_RS12415	COG0840	transmembrane signaling receptor activity
XapA_RS12425	COG0840	transmembrane signaling receptor activity
XapA_RS12430	COG0840	transmembrane signaling receptor activity
XapA_RS12435	COG0840	transmembrane signaling receptor activity
XapA_RS12440	COG0840	transmembrane signaling receptor activity
XapA_RS12445	COG0840	transmembrane signaling receptor activity
XapA_RS12460	COG0835	chemotaxis
XapA_RS12470	COG0840	transmembrane signaling receptor activity
XapA_RS12480	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XapA_RS12485	COG2201	protein-glutamate methylesterase activity
XapA_RS12495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XapA_RS12525	COG0318	PFAM AMP-dependent synthetase and ligase
XapA_RS12560	COG1024	Enoyl-CoA hydratase
XapA_RS12565	COG2205	protein histidine kinase activity
XapA_RS12565	COG2198	Histidine kinase
XapA_RS12565	COG0784	Response regulator, receiver
XapA_RS12575	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XapA_RS12585	COG3279	Response regulator of the LytR AlgR family
XapA_RS12640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XapA_RS12650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XapA_RS12655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XapA_RS12665	COG0505	Belongs to the CarA family
XapA_RS12670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XapA_RS12675	COG2258	MOSC domain
XapA_RS12725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XapA_RS12745	COG0277	FAD linked oxidase domain protein
XapA_RS12750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XapA_RS12760	COG0531	amino acid
XapA_RS12770	COG2188	Transcriptional regulator
XapA_RS12825	COG0531	amino acid
XapA_RS12830	COG0235	Class ii aldolase
XapA_RS12835	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XapA_RS12840	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XapA_RS12855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XapA_RS12855	COG0140	phosphoribosyl-ATP diphosphatase activity
XapA_RS12860	COG0107	imidazoleglycerol-phosphate synthase activity
XapA_RS12865	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XapA_RS12870	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XapA_RS12875	COG0131	Imidazoleglycerol-phosphate dehydratase
XapA_RS12875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XapA_RS12880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XapA_RS12885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XapA_RS12890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XapA_RS12900	COG0124	histidyl-tRNA synthetase
XapA_RS12905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XapA_RS13000	COG0726	polysaccharide deacetylase
XapA_RS13000	COG1649	PFAM Uncharacterised BCR, COG1649
XapA_RS13150	COG0531	amino acid
XapA_RS13165	COG0006	proline dipeptidase activity
XapA_RS13175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XapA_RS13190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapA_RS13195	COG3938	Belongs to the proline racemase family
XapA_RS13205	COG0552	protein localization to endoplasmic reticulum
XapA_RS13215	COG1194	a g-specific adenine glycosylase
XapA_RS13220	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XapA_RS13225	COG0784	Response regulator, receiver
XapA_RS13225	COG4191	Histidine kinase
XapA_RS13270	COG3040	lipid binding
XapA_RS13285	COG1960	acyl-CoA dehydrogenase activity
XapA_RS13295	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XapA_RS13315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XapA_RS13320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XapA_RS13325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XapA_RS13350	COG0438	transferase activity, transferring glycosyl groups
XapA_RS13360	COG0438	transferase activity, transferring glycosyl groups
XapA_RS13365	COG0438	transferase activity, transferring glycosyl groups
XapA_RS13415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XapA_RS13415	COG0072	phenylalanine-tRNA ligase activity
XapA_RS13420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XapA_RS13435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XapA_RS13440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XapA_RS13490	COG2948	multi-organism process
XapA_RS13510	COG3505	Type IV secretory pathway VirD4
XapA_RS13525	COG0556	nucleotide-excision repair
XapA_RS13580	COG1611	Belongs to the LOG family
XapA_RS13595	COG2095	MarC family integral membrane protein
XapA_RS13605	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XapA_RS13640	COG1185	polyribonucleotide nucleotidyltransferase activity
XapA_RS13645	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XapA_RS13650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XapA_RS13655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XapA_RS13660	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XapA_RS13665	COG0195	Participates in both transcription termination and antitermination
XapA_RS13670	COG0779	Required for maturation of 30S ribosomal subunits
XapA_RS13680	COG1007	ATP synthesis coupled electron transport
XapA_RS13700	COG0839	Belongs to the complex I subunit 6 family
XapA_RS13705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XapA_RS13710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XapA_RS13720	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XapA_RS13725	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XapA_RS13730	COG0649	NAD binding
XapA_RS13735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XapA_RS13740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XapA_RS13745	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XapA_RS13760	COG0149	triose-phosphate isomerase activity
XapA_RS13765	COG0300	oxidoreductase activity
XapA_RS13795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XapA_RS13800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XapA_RS13805	COG0159	tryptophan synthase activity
XapA_RS13815	COG0133	tryptophan synthase activity
XapA_RS13825	COG0135	phosphoribosylanthranilate isomerase activity
XapA_RS13830	COG0101	tRNA pseudouridine synthase activity
XapA_RS13850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XapA_RS13855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XapA_RS13860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XapA_RS13865	COG2890	protein-(glutamine-N5) methyltransferase activity
XapA_RS13875	COG0688	phosphatidylethanolamine metabolic process
XapA_RS13890	COG0433	COG0433 Predicted ATPase
XapA_RS13895	COG0494	nUDIX hydrolase
XapA_RS13915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XapA_RS13920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XapA_RS13935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XapA_RS13965	COG4695	Portal protein
XapA_RS14010	COG3179	chitinase
XapA_RS14210	COG0717	Belongs to the dCTP deaminase family
XapA_RS14220	COG0489	protein tyrosine kinase activity
XapA_RS14245	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XapA_RS14255	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XapA_RS14275	COG0534	Mate efflux family protein
XapA_RS14280	COG0335	large ribosomal subunit rRNA binding
XapA_RS14285	COG0336	Belongs to the RNA methyltransferase TrmD family
XapA_RS14290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XapA_RS14295	COG0228	four-way junction DNA binding
XapA_RS14300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XapA_RS14310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XapA_RS14315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XapA_RS14355	COG4999	Histidine kinase
XapA_RS14355	COG3437	response regulator, receiver
XapA_RS14355	COG3850	Histidine kinase
XapA_RS14355	COG2205	protein histidine kinase activity
XapA_RS14360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XapA_RS14370	COG2205	protein histidine kinase activity
XapA_RS14375	COG5507	3-demethylubiquinone-9 3-methyltransferase
XapA_RS14385	COG4771	TonB-dependent receptor
XapA_RS14410	COG2172	sigma factor antagonist activity
XapA_RS14415	COG1366	Belongs to the anti-sigma-factor antagonist family
XapA_RS14420	COG1366	Belongs to the anti-sigma-factor antagonist family
XapA_RS14430	COG0326	Molecular chaperone. Has ATPase activity
XapA_RS14435	COG2207	Transcriptional regulator
XapA_RS14445	COG3152	Membrane
XapA_RS14460	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XapA_RS14465	COG1845	cytochrome c oxidase, subunit III
XapA_RS14470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XapA_RS14485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XapA_RS14490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XapA_RS14495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XapA_RS14500	COG0196	riboflavin kinase activity
XapA_RS14510	COG0268	Binds directly to 16S ribosomal RNA
XapA_RS14515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XapA_RS14520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XapA_RS14525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XapA_RS14530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XapA_RS14535	COG0824	Thioesterase
XapA_RS14580	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XapA_RS14590	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XapA_RS14620	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XapA_RS14635	COG2197	response regulator
XapA_RS14640	COG4585	Histidine kinase
XapA_RS14655	COG0850	regulation of cytokinetic process
XapA_RS14660	COG2894	cell division
XapA_RS14665	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XapA_RS14675	COG0642	Histidine kinase
XapA_RS14680	COG0745	RESPONSE REGULATOR receiver
XapA_RS14695	COG2194	sulfuric ester hydrolase activity
XapA_RS14710	COG2814	Major facilitator Superfamily
XapA_RS14715	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XapA_RS14715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XapA_RS14725	COG0656	L-ascorbic acid biosynthetic process
XapA_RS14730	COG0753	catalase activity
XapA_RS14755	COG2207	Transcriptional regulator
XapA_RS14755	COG1917	Cupin 2, conserved barrel domain protein
XapA_RS14815	COG0492	ferredoxin-NADP+ reductase activity
XapA_RS14825	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS14830	COG3537	Alpha-1,2-mannosidase
XapA_RS14840	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS14845	COG3387	PFAM Glycoside hydrolase 15-related
XapA_RS14855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XapA_RS14895	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
XapA_RS14950	COG1309	transcriptional regulator
XapA_RS14955	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS14960	COG0308	aminopeptidase N
XapA_RS14965	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XapA_RS14975	COG0330	HflC and HflK could
XapA_RS14980	COG0330	HflC and HflK could
XapA_RS15000	COG0678	peroxiredoxin activity
XapA_RS15010	COG4953	penicillin-binding protein 1C
XapA_RS15030	COG2373	Large extracellular alpha-helical protein
XapA_RS15065	COG3609	addiction module antidote protein, CC2985 family
XapA_RS15085	COG3829	transcription factor binding
XapA_RS15110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XapA_RS15115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XapA_RS15130	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS15145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XapA_RS15150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XapA_RS15155	COG1399	metal-binding, possibly nucleic acid-binding protein
XapA_RS15160	COG0424	maF-like protein
XapA_RS15190	COG0714	Associated with various cellular activities
XapA_RS15210	COG0537	adenosine 5'-monophosphoramidase activity
XapA_RS15215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XapA_RS15220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XapA_RS15240	COG0314	molybdopterin synthase activity
XapA_RS15245	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XapA_RS15250	COG0315	cyclic pyranopterin monophosphate synthase activity
XapA_RS15255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XapA_RS15260	COG1234	tRNA 3'-trailer cleavage
XapA_RS15265	COG3642	lipopolysaccharide core region biosynthetic process
XapA_RS15270	COG0859	PFAM glycosyl transferase family 9
XapA_RS15285	COG0631	protein serine/threonine phosphatase activity
XapA_RS15290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XapA_RS15295	COG0328	RNA-DNA hybrid ribonuclease activity
XapA_RS15305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XapA_RS15315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XapA_RS15340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XapA_RS15350	COG0544	peptidyl-prolyl cis-trans isomerase activity
XapA_RS15360	COG3852	Histidine kinase
XapA_RS15390	COG0473	3-isopropylmalate dehydrogenase activity
XapA_RS15405	COG4783	chaperone-mediated protein folding
XapA_RS15420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XapA_RS15430	COG0438	transferase activity, transferring glycosyl groups
XapA_RS15435	COG0671	phosphoesterase, PA-phosphatase related
XapA_RS15440	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XapA_RS15460	COG2833	Protein of unknown function (DUF455)
XapA_RS15480	COG0285	dihydrofolate synthase activity
XapA_RS15495	COG0406	alpha-ribazole phosphatase activity
XapA_RS15525	COG1063	alcohol dehydrogenase
XapA_RS15535	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XapA_RS15540	COG4208	sulfate ABC transporter
XapA_RS15545	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XapA_RS15550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XapA_RS15555	COG0156	8-amino-7-oxononanoate synthase activity
XapA_RS15590	COG0446	pyridine nucleotide-disulphide oxidoreductase
XapA_RS15590	COG1902	pentaerythritol trinitrate reductase activity
XapA_RS15610	COG0625	glutathione transferase activity
XapA_RS15620	COG0039	L-malate dehydrogenase activity
XapA_RS15625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XapA_RS15640	COG0154	amidase activity
XapA_RS15650	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XapA_RS15670	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XapA_RS15675	COG0203	ribosomal protein L17
XapA_RS15700	COG0201	protein transport
XapA_RS15705	COG0200	Binds to the 23S rRNA
XapA_RS15710	COG1841	ribosomal large subunit assembly
XapA_RS15720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XapA_RS15725	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XapA_RS15730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XapA_RS15740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XapA_RS15745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XapA_RS15755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XapA_RS15760	COG0255	Belongs to the universal ribosomal protein uL29 family
XapA_RS15765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XapA_RS15770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XapA_RS15780	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XapA_RS15785	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XapA_RS15790	COG0089	rRNA binding
XapA_RS15795	COG0088	Forms part of the polypeptide exit tunnel
XapA_RS15800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XapA_RS15805	COG0051	transcription antitermination factor activity, RNA binding
XapA_RS15810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XapA_RS15815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XapA_RS15820	COG0049	tRNA binding
XapA_RS15825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XapA_RS15830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XapA_RS15835	COG0085	RNA polymerase activity
XapA_RS15840	COG0222	ribosome binding
XapA_RS15845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XapA_RS15850	COG0081	regulation of translation
XapA_RS15855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XapA_RS15860	COG0250	Participates in transcription elongation, termination and antitermination
XapA_RS15875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XapA_RS15895	COG0012	GTP binding
XapA_RS15900	COG0193	aminoacyl-tRNA hydrolase activity
XapA_RS15905	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XapA_RS15910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XapA_RS15920	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XapA_RS15925	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XapA_RS15935	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XapA_RS15940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XapA_RS15970	COG1254	Belongs to the acylphosphatase family
XapA_RS15980	COG1295	ribonuclease BN
XapA_RS16005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XapA_RS16010	COG1404	Belongs to the peptidase S8 family
XapA_RS16020	COG1404	Belongs to the peptidase S8 family
XapA_RS16030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XapA_RS16050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XapA_RS16070	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XapA_RS16100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XapA_RS16100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XapA_RS16120	COG2890	protein-(glutamine-N5) methyltransferase activity
XapA_RS16130	COG3634	alkyl hydroperoxide reductase activity
XapA_RS16135	COG0583	DNA-binding transcription factor activity
XapA_RS16145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XapA_RS16150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XapA_RS16160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XapA_RS16195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XapA_RS16205	COG0697	spore germination
XapA_RS16225	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XapA_RS16240	COG3386	PFAM SMP-30 Gluconolaconase
XapA_RS16260	COG1024	Enoyl-CoA hydratase
XapA_RS16270	COG0318	PFAM AMP-dependent synthetase and ligase
XapA_RS16275	COG0583	DNA-binding transcription factor activity
XapA_RS16280	COG3384	dioxygenase
XapA_RS16310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XapA_RS16315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XapA_RS16330	COG2096	Adenosyltransferase
XapA_RS16335	COG0123	including yeast histone deacetylase and acetoin utilization protein
XapA_RS16340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XapA_RS16345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XapA_RS16350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XapA_RS16355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XapA_RS16360	COG2967	ApaG domain
XapA_RS16365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XapA_RS16385	COG0747	negative chemotaxis
XapA_RS16410	COG0431	NADPH-dependent FMN reductase
XapA_RS16415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XapA_RS16425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XapA_RS16430	COG1116	anion transmembrane transporter activity
XapA_RS16440	COG3829	transcription factor binding
XapA_RS16455	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XapA_RS16460	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XapA_RS16495	COG0588	phosphoglycerate mutase activity
XapA_RS16500	COG1515	deoxyribonuclease V activity
XapA_RS16510	COG1741	Belongs to the pirin family
XapA_RS16525	COG1741	Belongs to the pirin family
XapA_RS16530	COG1966	Carbon starvation protein
XapA_RS16535	COG2879	small protein
XapA_RS16585	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XapA_RS16590	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XapA_RS16595	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XapA_RS16600	COG2080	2 iron, 2 sulfur cluster binding
XapA_RS16605	COG0604	alcohol dehydrogenase
XapA_RS16605	COG3321	synthase
XapA_RS16605	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS16610	COG2203	Gaf domain
XapA_RS16610	COG3706	GGDEF domain
XapA_RS16610	COG5001	Diguanylate cyclase
XapA_RS16610	COG4251	negative regulation of phosphorylation
XapA_RS16615	COG0629	single-stranded DNA binding
XapA_RS16620	COG0142	geranyltranstransferase activity
XapA_RS16635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XapA_RS16650	COG0527	aspartate kinase activity
XapA_RS16655	COG0384	phenazine biosynthesis protein PhzF
XapA_RS16670	COG1764	response to oxidative stress
XapA_RS16675	COG0540	Belongs to the ATCase OTCase family
XapA_RS16680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XapA_RS16685	COG1678	Uncharacterized ACR, COG1678
XapA_RS16695	COG0519	Catalyzes the synthesis of GMP from XMP
XapA_RS16705	COG5297	Belongs to the glycosyl hydrolase family 6
XapA_RS16720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XapA_RS16735	COG0739	heme binding
XapA_RS16755	COG0693	protein deglycase activity
XapA_RS16765	COG1959	2 iron, 2 sulfur cluster binding
XapA_RS16770	COG0719	Fe-S assembly protein
XapA_RS16775	COG0396	ATPase activity
XapA_RS16780	COG0719	Fe-S assembly protein
XapA_RS16785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XapA_RS16795	COG2146	nitrite reductase [NAD(P)H] activity
XapA_RS16800	COG4774	siderophore transport
XapA_RS16805	COG3128	pkhd-type hydroxylase
XapA_RS16830	COG1477	protein flavinylation
XapA_RS16835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XapA_RS16850	COG1555	photosystem II stabilization
XapA_RS16865	COG3178	'Phosphotransferase
XapA_RS16870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XapA_RS16880	COG0628	permease
XapA_RS16890	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XapA_RS16900	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XapA_RS16920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XapA_RS16925	COG0271	Belongs to the BolA IbaG family
XapA_RS16935	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XapA_RS16945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XapA_RS16950	COG1137	ATPase activity
XapA_RS16965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XapA_RS16970	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XapA_RS16975	COG1660	Displays ATPase and GTPase activities
XapA_RS16985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XapA_RS16990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XapA_RS17000	COG2239	Acts as a magnesium transporter
XapA_RS17015	COG1294	oxidase, subunit
XapA_RS17020	COG1271	oxidase subunit
XapA_RS17040	COG1113	amino acid transport
XapA_RS17070	COG2197	response regulator
XapA_RS17075	COG0531	amino acid
XapA_RS17105	COG1234	tRNA 3'-trailer cleavage
XapA_RS17175	COG2814	Major facilitator Superfamily
XapA_RS17185	COG0754	glutathionylspermidine amidase activity
XapA_RS17210	COG1842	Phage shock protein A
XapA_RS17220	COG0259	pyridoxamine-phosphate oxidase activity
XapA_RS17225	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XapA_RS17230	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XapA_RS17240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XapA_RS17245	COG0477	Major facilitator Superfamily
XapA_RS17265	COG0784	Response regulator, receiver
XapA_RS17265	COG2205	protein histidine kinase activity
XapA_RS17265	COG2198	Histidine kinase
XapA_RS17270	COG2353	YceI-like domain
XapA_RS17290	COG1760	l-serine dehydratase
XapA_RS17305	COG0527	aspartate kinase activity
XapA_RS17305	COG0460	homoserine dehydrogenase
XapA_RS17310	COG0626	cystathionine gamma-synthase activity
XapA_RS17315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XapA_RS17320	COG0739	heme binding
XapA_RS17325	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XapA_RS17330	COG1272	protein, Hemolysin III
XapA_RS17335	COG2982	Protein involved in outer membrane biogenesis
XapA_RS17340	COG0516	GMP reductase activity
XapA_RS17340	COG0517	IMP dehydrogenase activity
XapA_RS17345	COG0463	Glycosyl transferase, family 2
XapA_RS17350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XapA_RS17355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XapA_RS17365	COG4771	TonB-dependent receptor
XapA_RS17380	COG1309	transcriptional regulator
XapA_RS17390	COG1960	acyl-CoA dehydrogenase activity
XapA_RS17420	COG0509	glycine decarboxylation via glycine cleavage system
XapA_RS17425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XapA_RS17445	COG1742	UPF0060 membrane protein
XapA_RS17450	COG3956	TIGRFAM MazG family protein
XapA_RS17460	COG0494	nUDIX hydrolase
XapA_RS17470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XapA_RS17475	COG0837	glucose binding
XapA_RS17490	COG1388	LysM domain
XapA_RS17490	COG3858	chitin binding
XapA_RS17505	COG1472	Belongs to the glycosyl hydrolase 3 family
XapA_RS17545	COG3537	Alpha-1,2-mannosidase
XapA_RS17585	COG3142	Participates in the control of copper homeostasis
XapA_RS17590	COG1446	asparaginase
XapA_RS17620	COG0643	Histidine kinase
XapA_RS17620	COG0784	Response regulator, receiver
XapA_RS17620	COG2198	Histidine kinase
XapA_RS17625	COG0840	transmembrane signaling receptor activity
XapA_RS17630	COG0835	chemotaxis
XapA_RS17645	COG0189	ligase activity
XapA_RS17655	COG1397	ADP-ribosylglycohydrolase
XapA_RS17665	COG1199	ATP-dependent helicase activity
XapA_RS17675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XapA_RS17680	COG1215	transferase activity, transferring glycosyl groups
XapA_RS17695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XapA_RS17705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XapA_RS17710	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XapA_RS17715	COG0535	radical SAM domain protein
XapA_RS17720	COG0535	radical SAM domain protein
XapA_RS17750	COG1643	Atp-dependent helicase
XapA_RS17755	COG0783	Belongs to the Dps family
XapA_RS17765	COG0514	ATP-dependent DNA helicase (RecQ)
XapA_RS17800	COG0840	transmembrane signaling receptor activity
XapA_RS17820	COG3920	Histidine kinase
XapA_RS17825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XapA_RS17835	COG0602	queuosine metabolic process
XapA_RS17845	COG2885	chlorophyll binding
XapA_RS17850	COG0823	Involved in the tonB-independent uptake of proteins
XapA_RS17860	COG0848	biopolymer transport protein
XapA_RS17870	COG0824	Thioesterase
XapA_RS17875	COG2255	four-way junction helicase activity
XapA_RS17885	COG3158	transport of potassium into the cell
XapA_RS17890	COG0632	four-way junction helicase activity
XapA_RS17895	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XapA_RS17900	COG0217	transcriptional regulatory protein
XapA_RS17915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XapA_RS17930	COG0477	Major facilitator Superfamily
XapA_RS17970	COG0488	(ABC) transporter
XapA_RS18010	COG4651	solute:proton antiporter activity
XapA_RS18010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XapA_RS18035	COG4772	TonB-dependent receptor
XapA_RS18045	COG4264	IucA IucC family
XapA_RS18060	COG0019	diaminopimelate decarboxylase activity
XapA_RS18090	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XapA_RS18100	COG1492	cobalamin metabolic process
XapA_RS18130	COG4206	TonB-dependent receptor
XapA_RS18135	COG0542	response to heat
XapA_RS18140	COG1116	anion transmembrane transporter activity
XapA_RS18145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XapA_RS18150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XapA_RS18155	COG0667	Aldo Keto reductase
XapA_RS18160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XapA_RS18165	COG4771	TonB-dependent receptor
XapA_RS18180	COG2827	Endonuclease containing a URI domain
XapA_RS18225	COG1877	trehalose-phosphatase activity
XapA_RS18230	COG3387	PFAM Glycoside hydrolase 15-related
XapA_RS18250	COG0840	transmembrane signaling receptor activity
XapA_RS18255	COG3011	Protein conserved in bacteria
XapA_RS18270	COG0564	pseudouridine synthase activity
XapA_RS18275	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XapA_RS18285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XapA_RS18285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XapA_RS18295	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XapA_RS18300	COG0045	succinate-CoA ligase (ADP-forming) activity
XapA_RS18345	COG1459	type II secretion system
XapA_RS18350	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XapA_RS18355	COG0237	dephospho-CoA kinase activity
XapA_RS18375	COG0436	Aminotransferase
XapA_RS18405	COG0726	polysaccharide deacetylase
XapA_RS18410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XapA_RS18425	COG3964	amidohydrolase
XapA_RS18430	COG0402	S-adenosylhomocysteine deaminase activity
XapA_RS18465	COG1307	EDD domain protein, DegV family
XapA_RS18470	COG0242	peptide deformylase activity
XapA_RS18500	COG0457	Tetratricopeptide repeat
XapA_RS18505	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XapA_RS18510	COG1215	transferase activity, transferring glycosyl groups
XapA_RS18515	COG1215	transferase activity, transferring glycosyl groups
XapA_RS18530	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XapA_RS18595	COG2188	Transcriptional regulator
XapA_RS18610	COG1450	Type ii and iii secretion system protein
XapA_RS18625	COG3166	PFAM Fimbrial assembly family protein
XapA_RS18630	COG3156	type II secretion system protein K
XapA_RS18635	COG4795	General secretion pathway protein
XapA_RS18640	COG2165	general secretion pathway protein
XapA_RS18645	COG4970	Tfp pilus assembly protein FimT
XapA_RS18650	COG2165	general secretion pathway protein
XapA_RS18655	COG1459	type II secretion system
XapA_RS18665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XapA_RS18670	COG1404	Belongs to the peptidase S8 family
XapA_RS18675	COG5295	Hep Hag repeat protein
XapA_RS18680	COG1404	Belongs to the peptidase S8 family
XapA_RS18685	COG5295	Hep Hag repeat protein
XapA_RS18690	COG0047	phosphoribosylformylglycinamidine synthase activity
XapA_RS18690	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XapA_RS18700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XapA_RS18710	COG4974	Belongs to the 'phage' integrase family
XapA_RS18725	COG0795	lipopolysaccharide-transporting ATPase activity
XapA_RS18735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XapA_RS18750	COG0525	valine-tRNA ligase activity
XapA_RS18770	COG0741	lytic transglycosylase activity
XapA_RS18790	COG1183	phosphatidylcholine synthase activity
XapA_RS18800	COG0442	prolyl-tRNA aminoacylation
XapA_RS18815	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XapA_RS18820	COG1127	ABC transporter
XapA_RS18825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XapA_RS18825	COG3218	ABC-type transport auxiliary lipoprotein component
XapA_RS18860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XapA_RS18865	COG0662	Cupin 2, conserved barrel domain protein
XapA_RS18865	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XapA_RS18895	COG2086	electron transfer activity
XapA_RS18910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XapA_RS18910	COG0546	phosphoglycolate phosphatase activity
XapA_RS18915	COG0277	FAD linked oxidase domain protein
XapA_RS18930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XapA_RS18965	COG1216	Glycosyl transferase, family 2
XapA_RS18965	COG0438	transferase activity, transferring glycosyl groups
XapA_RS18985	COG0626	cystathionine gamma-synthase activity
XapA_RS19015	COG0625	glutathione transferase activity
XapA_RS19030	COG0513	Belongs to the DEAD box helicase family
XapA_RS19040	COG4206	TonB-dependent receptor
XapA_RS19050	COG0720	synthase
XapA_RS19060	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XapA_RS19070	COG1956	GAF domain-containing protein
XapA_RS19080	COG2819	hydrolase of the alpha beta superfamily
XapA_RS19095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XapA_RS19100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XapA_RS19115	COG0339	signal peptide processing
XapA_RS19130	COG2132	Multicopper oxidase
XapA_RS19170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XapA_RS19175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_RS19180	COG1136	(ABC) transporter
XapA_RS19180	COG4591	ABC-type transport system involved in lipoprotein release permease component
XapA_RS19185	COG0577	efflux transmembrane transporter activity
XapA_RS19190	COG0577	efflux transmembrane transporter activity
XapA_RS19205	COG4191	Histidine kinase
XapA_RS19210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XapA_RS19225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XapA_RS19230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XapA_RS19235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XapA_RS19240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XapA_RS19245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XapA_RS19250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XapA_RS19260	COG0356	it plays a direct role in the translocation of protons across the membrane
XapA_RS19280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XapA_RS19290	COG0508	dehydrogenase complex catalyzes the overall conversion of
XapA_RS19335	COG2011	ABC-type metal ion transport system permease component
XapA_RS19340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XapA_RS19345	COG0697	spore germination
XapA_RS19350	COG1666	GTP binding
XapA_RS19360	COG5002	protein histidine kinase activity
XapA_RS19360	COG0784	Response regulator, receiver
XapA_RS19360	COG2198	Histidine kinase
XapA_RS19385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XapA_RS19390	COG1187	pseudouridine synthase activity
XapA_RS19395	COG2813	Specifically methylates the guanine in position
XapA_RS19415	COG2205	protein histidine kinase activity
XapA_RS19415	COG2202	Pas domain
XapA_RS19435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XapA_RS19440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapA_RS19500	COG0842	Transport permease protein
XapA_RS19510	COG0025	NhaP-type Na H and K H
XapA_RS19520	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XapA_RS19525	COG1573	uracil-dna glycosylase
XapA_RS19535	COG3384	dioxygenase
XapA_RS19555	COG0667	Aldo Keto reductase
XapA_RS19570	COG3590	peptidase
XapA_RS19590	COG0531	amino acid
XapA_RS19605	COG2972	Histidine kinase
XapA_RS19630	COG3685	Protein conserved in bacteria
XapA_RS19635	COG3546	catalase activity
XapA_RS19685	COG1271	oxidase subunit
XapA_RS19690	COG1294	oxidase, subunit
XapA_RS19710	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS19715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XapA_RS19745	COG1132	(ABC) transporter
XapA_RS19770	COG1063	alcohol dehydrogenase
XapA_RS19845	COG0251	oxidation-reduction process
XapA_RS19860	COG0840	transmembrane signaling receptor activity
XapA_RS19875	COG0583	DNA-binding transcription factor activity
XapA_RS19880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XapA_RS19955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XapA_RS19960	COG1490	D-aminoacyl-tRNA deacylase activity
XapA_RS19965	COG1560	Kdo2-lipid A biosynthetic process
XapA_RS20020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XapA_RS20020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XapA_RS20025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XapA_RS20030	COG0242	peptide deformylase activity
XapA_RS20035	COG1652	LysM domain
XapA_RS20040	COG0758	DNA mediated transformation
XapA_RS20060	COG1754	DNA topoisomerase type I activity
XapA_RS20060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XapA_RS20065	COG0009	L-threonylcarbamoyladenylate synthase
XapA_RS20080	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS20095	COG0616	signal peptide processing
XapA_RS20100	COG0534	Mate efflux family protein
XapA_RS20120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XapA_RS20125	COG0625	glutathione transferase activity
XapA_RS20140	COG1252	NADH dehydrogenase
XapA_RS20150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XapA_RS20155	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XapA_RS20160	COG3437	response regulator, receiver
XapA_RS20165	COG2177	Part of the ABC transporter FtsEX involved in
XapA_RS20170	COG2884	Cell division ATP-binding protein ftsE
XapA_RS20175	COG0513	Belongs to the DEAD box helicase family
XapA_RS20180	COG3118	belongs to the thioredoxin family
XapA_RS20185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XapA_RS20190	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XapA_RS20195	COG0583	DNA-binding transcription factor activity
XapA_RS20240	COG1518	maintenance of DNA repeat elements
XapA_RS20245	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
XapA_RS20255	COG1652	LysM domain
XapA_RS20260	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XapA_RS20260	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XapA_RS20265	COG1473	amidohydrolase
XapA_RS20270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_RS20275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapA_RS20285	COG5383	Protein conserved in bacteria
XapA_RS20335	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XapA_RS20340	COG3023	N-Acetylmuramoyl-L-alanine amidase
XapA_RS20350	COG4948	Mandelate Racemase Muconate Lactonizing
XapA_RS20360	COG0531	amino acid
XapA_RS20375	COG4682	membrane
XapA_RS20380	COG2133	pyrroloquinoline quinone binding
XapA_RS20390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XapA_RS20395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XapA_RS20405	COG1610	YqeY-like protein
XapA_RS20415	COG1295	ribonuclease BN
XapA_RS20420	COG0358	DNA primase activity
XapA_RS20435	COG0109	protoheme IX farnesyltransferase activity
XapA_RS20465	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XapA_RS20480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XapA_RS20520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XapA_RS20525	COG0739	heme binding
XapA_RS20530	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XapA_RS20540	COG2211	Major facilitator Superfamily
XapA_RS20545	COG0708	Exodeoxyribonuclease III
XapA_RS20550	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XapA_RS20560	COG1192	Involved in chromosome partitioning
XapA_RS20565	COG1475	DNA binding
XapA_RS20585	COG0463	Glycosyl transferase, family 2
XapA_RS20605	COG0756	dUTP diphosphatase activity
XapA_RS20610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XapA_RS20615	COG2003	Belongs to the UPF0758 family
XapA_RS20620	COG0018	arginyl-trna synthetase
XapA_RS20635	COG4221	oxidoreductase activity
XapA_RS20640	COG2755	lipolytic protein G-D-S-L family
XapA_RS20640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XapA_RS20650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XapA_RS20655	COG1166	arginine decarboxylase activity
XapA_RS20660	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XapA_RS20705	COG2960	long-chain fatty acid transporting porin activity
XapA_RS20710	COG0606	chelatase, subunit chli
XapA_RS20725	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XapA_RS20760	COG1690	Belongs to the RtcB family
XapA_RS20795	COG1090	epimerase
XapA_RS20800	COG0745	RESPONSE REGULATOR receiver
XapA_RS20805	COG0642	Histidine kinase
XapA_RS20835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XapA_RS20860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XapA_RS20865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XapA_RS20880	COG0753	catalase activity
XapA_RS20905	COG2197	response regulator
XapA_RS20910	COG4585	Histidine kinase
XapA_RS20915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_RS20920	COG1136	(ABC) transporter
XapA_RS20945	COG0697	spore germination
XapA_RS20965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XapA_RS20970	COG0180	Tryptophanyl-tRNA synthetase
XapA_RS20975	COG3237	CsbD-like
XapA_RS21020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XapA_RS21075	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XapA_RS21080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XapA_RS21080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XapA_RS21110	COG2205	protein histidine kinase activity
XapA_RS21115	COG0745	RESPONSE REGULATOR receiver
XapA_RS21125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XapA_RS21155	COG1199	ATP-dependent helicase activity
XapA_RS21170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XapA_RS21240	COG0625	glutathione transferase activity
XapA_RS21280	COG4555	ABC transporter
XapA_RS21290	COG1476	TRANSCRIPTIONal
XapA_RS21335	COG0633	Ferredoxin
XapA_RS21335	COG0543	2 iron, 2 sulfur cluster binding
XapA_RS21340	COG1131	(ABC) transporter
XapA_RS21345	COG0842	Transport permease protein
XapA_RS21355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XapA_RS21390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XapA_RS21400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XapA_RS21415	COG0045	succinate-CoA ligase (ADP-forming) activity
XapA_RS21415	COG1042	CoA-binding domain protein
XapA_RS21415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XapA_RS21420	COG2239	Acts as a magnesium transporter
XapA_RS21440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XapA_RS21445	COG3387	PFAM Glycoside hydrolase 15-related
XapA_RS21460	COG3100	YcgL domain-containing protein
XapA_RS21465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XapA_RS21475	COG0463	Glycosyl transferase, family 2
XapA_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS21525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XapA_RS21540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XapA_RS21570	COG0823	Involved in the tonB-independent uptake of proteins
XapA_RS21570	COG1506	peptidase
XapA_RS21570	COG4946	Tricorn protease homolog
XapA_RS21590	COG0408	coproporphyrinogen oxidase activity
XapA_RS21630	COG0515	serine threonine protein kinase
XapA_RS21635	COG0631	protein serine/threonine phosphatase activity
XapA_RS21670	COG3501	Rhs element vgr protein
XapA_RS21835	COG0210	DNA helicase
XapA_RS21850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapA_RS21855	COG0583	DNA-binding transcription factor activity
XapA_RS21860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XapA_RS21875	COG2159	amidohydrolase
XapA_RS21905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_RS21925	COG0357	Ribosomal RNA small subunit methyltransferase G
XapA_RS21930	COG3540	Alkaline phosphatase
XapA_RS21940	COG2091	lysine biosynthetic process via aminoadipic acid
XapA_RS21955	COG0708	Exodeoxyribonuclease III
XapA_RS21960	COG1846	Transcriptional regulator
XapA_RS21960	COG1940	carbohydrate kinase activity
XapA_RS21970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XapA_RS21980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XapA_RS21985	COG3162	membrane
XapA_RS21995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XapA_RS22035	COG3507	Belongs to the glycosyl hydrolase 43 family
XapA_RS22055	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS22060	COG0179	Fumarylacetoacetate (FAA) hydrolase
XapA_RS22070	COG4948	Mandelate Racemase Muconate Lactonizing
XapA_RS22075	COG3254	rhamnose metabolic process
XapA_RS22080	COG0738	Major facilitator superfamily
XapA_RS22085	COG1414	Transcriptional regulator
XapA_RS22095	COG1971	Probably functions as a manganese efflux pump
XapA_RS22100	COG2205	protein histidine kinase activity
XapA_RS22115	COG3459	Glycosyltransferase 36 associated
XapA_RS22120	COG2211	Major facilitator Superfamily
XapA_RS22125	COG3265	gluconokinase activity
XapA_RS22135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XapA_RS22155	COG2911	Protein conserved in bacteria
XapA_RS22160	COG0729	surface antigen
XapA_RS22220	COG0752	glycyl-tRNA synthetase alpha subunit
XapA_RS22240	COG0519	Catalyzes the synthesis of GMP from XMP
XapA_RS22240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XapA_RS22250	COG0805	protein transport
XapA_RS22255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XapA_RS22260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XapA_RS22270	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XapA_RS22295	COG2974	May be involved in recombination
XapA_RS22300	COG0037	tRNA processing
XapA_RS22310	COG2115	Belongs to the xylose isomerase family
XapA_RS22330	COG4948	Mandelate Racemase Muconate Lactonizing
XapA_RS22340	COG1472	Belongs to the glycosyl hydrolase 3 family
XapA_RS22345	COG0246	Mannitol dehydrogenase
XapA_RS22390	COG3002	Belongs to the UPF0753 family
XapA_RS22445	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapA_RS22495	COG3318	Belongs to the UPF0149 family
XapA_RS22495	COG3012	SEC-C Motif Domain Protein
XapA_RS22515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapA_RS22535	COG0662	Cupin 2, conserved barrel domain protein
XapA_RS22555	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XapA_RS22585	COG0714	Associated with various cellular activities
XapA_RS22625	COG0477	Major facilitator Superfamily
XapA_RS22635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XapA_RS22680	COG3237	CsbD-like
XapA_RS22740	COG0564	pseudouridine synthase activity
XapA_RS22780	COG1309	transcriptional regulator
XapA_RS22790	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_RS22845	COG3039	Transposase
XapA_RS22865	COG1074	ATP-dependent DNA helicase activity
XapA_RS22870	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XapA_RS22885	COG1127	ABC transporter
XapA_RS22890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XapA_RS22895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XapA_RS22910	COG2853	Lipoprotein
XapA_RS22920	COG0386	Belongs to the glutathione peroxidase family
XapA_RS22930	COG1322	Protein conserved in bacteria
XapA_RS22935	COG0604	alcohol dehydrogenase
XapA_RS22940	COG0583	DNA-binding transcription factor activity
XapA_RS22955	COG0625	glutathione transferase activity
XapA_RS22965	COG0531	amino acid
XapA_RS23020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XapA_RS23030	COG0861	Integral membrane protein TerC family
XapA_RS23045	COG0584	glycerophosphoryl diester phosphodiesterase
XapA_RS23060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XapA_RS23065	COG0726	polysaccharide deacetylase
XapA_RS23070	COG0706	membrane insertase activity
XapA_RS23075	COG0594	ribonuclease P activity
XapA_RS23170	COG1192	Involved in chromosome partitioning
XapA_RS23410	COG1192	Involved in chromosome partitioning
XapA_RS23525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XapA_RS23540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XapA_RS23600	COG1487	ribonuclease activity
XapA_RS23605	COG4691	Plasmid stability protein
XapA_RS23820	COG2948	multi-organism process
XapA_RS23825	COG3504	Conjugal transfer protein
XapA_RS23835	COG3704	protein secretion by the type IV secretion system