locus-tag	class	description
DOO79_RS00055	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DOO79_RS00055	COG0546	phosphoglycolate phosphatase activity
DOO79_RS00075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOO79_RS00110	COG0438	transferase activity, transferring glycosyl groups
DOO79_RS00110	COG1216	Glycosyl transferase, family 2
DOO79_RS00130	COG0626	cystathionine gamma-synthase activity
DOO79_RS00160	COG0625	glutathione transferase activity
DOO79_RS00170	COG0513	Belongs to the DEAD box helicase family
DOO79_RS00180	COG4206	TonB-dependent receptor
DOO79_RS00185	COG0720	synthase
DOO79_RS00195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DOO79_RS00200	COG1956	GAF domain-containing protein
DOO79_RS00210	COG2819	hydrolase of the alpha beta superfamily
DOO79_RS00225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DOO79_RS00230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DOO79_RS00245	COG0339	signal peptide processing
DOO79_RS00260	COG2132	Multicopper oxidase
DOO79_RS00300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DOO79_RS00305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DOO79_RS00310	COG1136	(ABC) transporter
DOO79_RS00310	COG4591	ABC-type transport system involved in lipoprotein release permease component
DOO79_RS00315	COG0577	efflux transmembrane transporter activity
DOO79_RS00320	COG0577	efflux transmembrane transporter activity
DOO79_RS00335	COG4191	Histidine kinase
DOO79_RS00340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DOO79_RS00355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DOO79_RS00360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DOO79_RS00365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DOO79_RS00370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DOO79_RS00375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DOO79_RS00380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DOO79_RS00390	COG0356	it plays a direct role in the translocation of protons across the membrane
DOO79_RS00410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DOO79_RS00420	COG0508	dehydrogenase complex catalyzes the overall conversion of
DOO79_RS00465	COG2011	ABC-type metal ion transport system permease component
DOO79_RS00470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DOO79_RS00475	COG0697	spore germination
DOO79_RS00480	COG1666	GTP binding
DOO79_RS00490	COG2198	Histidine kinase
DOO79_RS00490	COG5002	protein histidine kinase activity
DOO79_RS00490	COG0784	Response regulator, receiver
DOO79_RS00510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOO79_RS00515	COG1187	pseudouridine synthase activity
DOO79_RS00520	COG2813	Specifically methylates the guanine in position
DOO79_RS00540	COG2205	protein histidine kinase activity
DOO79_RS00540	COG2202	Pas domain
DOO79_RS00560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DOO79_RS00565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DOO79_RS00620	COG0842	Transport permease protein
DOO79_RS00630	COG0025	NhaP-type Na H and K H
DOO79_RS00635	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DOO79_RS00640	COG1573	uracil-dna glycosylase
DOO79_RS00650	COG3384	dioxygenase
DOO79_RS00670	COG0667	Aldo Keto reductase
DOO79_RS00680	COG3590	peptidase
DOO79_RS00700	COG0531	amino acid
DOO79_RS00715	COG2972	Histidine kinase
DOO79_RS00730	COG3685	Protein conserved in bacteria
DOO79_RS00735	COG3546	catalase activity
DOO79_RS00780	COG1271	oxidase subunit
DOO79_RS00785	COG1294	oxidase, subunit
DOO79_RS00805	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS00810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DOO79_RS00840	COG1132	(ABC) transporter
DOO79_RS00865	COG1063	alcohol dehydrogenase
DOO79_RS00940	COG0251	oxidation-reduction process
DOO79_RS00955	COG0840	transmembrane signaling receptor activity
DOO79_RS00970	COG0583	DNA-binding transcription factor activity
DOO79_RS00975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DOO79_RS01050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DOO79_RS01055	COG1490	D-aminoacyl-tRNA deacylase activity
DOO79_RS01060	COG1560	Kdo2-lipid A biosynthetic process
DOO79_RS01110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DOO79_RS01110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DOO79_RS01115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DOO79_RS01120	COG0242	peptide deformylase activity
DOO79_RS01125	COG1652	LysM domain
DOO79_RS01130	COG0758	DNA mediated transformation
DOO79_RS01150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DOO79_RS01150	COG1754	DNA topoisomerase type I activity
DOO79_RS01155	COG0009	L-threonylcarbamoyladenylate synthase
DOO79_RS01170	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS01180	COG0616	signal peptide processing
DOO79_RS01185	COG0534	Mate efflux family protein
DOO79_RS01205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DOO79_RS01210	COG0625	glutathione transferase activity
DOO79_RS01225	COG1252	NADH dehydrogenase
DOO79_RS01235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DOO79_RS01240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DOO79_RS01245	COG2201	protein-glutamate methylesterase activity
DOO79_RS01250	COG2177	Part of the ABC transporter FtsEX involved in
DOO79_RS01255	COG2884	Cell division ATP-binding protein ftsE
DOO79_RS01260	COG0513	Belongs to the DEAD box helicase family
DOO79_RS01265	COG3118	belongs to the thioredoxin family
DOO79_RS01270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DOO79_RS01275	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DOO79_RS01280	COG0583	DNA-binding transcription factor activity
DOO79_RS01325	COG1518	maintenance of DNA repeat elements
DOO79_RS01330	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DOO79_RS01340	COG1652	LysM domain
DOO79_RS01345	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DOO79_RS01345	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DOO79_RS01350	COG1473	amidohydrolase
DOO79_RS01355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DOO79_RS01360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DOO79_RS01370	COG5383	Protein conserved in bacteria
DOO79_RS01410	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DOO79_RS01415	COG3023	N-Acetylmuramoyl-L-alanine amidase
DOO79_RS01425	COG4948	Mandelate Racemase Muconate Lactonizing
DOO79_RS01435	COG0531	amino acid
DOO79_RS01450	COG4682	membrane
DOO79_RS01455	COG2133	pyrroloquinoline quinone binding
DOO79_RS01465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DOO79_RS01470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DOO79_RS01480	COG1610	YqeY-like protein
DOO79_RS01485	COG1295	ribonuclease BN
DOO79_RS01490	COG0358	DNA primase activity
DOO79_RS01505	COG0109	protoheme IX farnesyltransferase activity
DOO79_RS01535	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DOO79_RS01550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DOO79_RS01590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DOO79_RS01595	COG0739	heme binding
DOO79_RS01600	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DOO79_RS01610	COG2211	Major facilitator Superfamily
DOO79_RS01615	COG0708	Exodeoxyribonuclease III
DOO79_RS01620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DOO79_RS01630	COG1192	Involved in chromosome partitioning
DOO79_RS01635	COG1475	DNA binding
DOO79_RS01650	COG0463	Glycosyl transferase, family 2
DOO79_RS01670	COG0756	dUTP diphosphatase activity
DOO79_RS01675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DOO79_RS01680	COG2003	Belongs to the UPF0758 family
DOO79_RS01685	COG0018	arginyl-trna synthetase
DOO79_RS01700	COG4221	oxidoreductase activity
DOO79_RS01705	COG2755	lipolytic protein G-D-S-L family
DOO79_RS01705	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DOO79_RS01715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DOO79_RS01720	COG1166	arginine decarboxylase activity
DOO79_RS01725	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DOO79_RS01765	COG2960	long-chain fatty acid transporting porin activity
DOO79_RS01770	COG0606	chelatase, subunit chli
DOO79_RS01785	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DOO79_RS01815	COG1690	Belongs to the RtcB family
DOO79_RS01850	COG1090	epimerase
DOO79_RS01860	COG0642	Histidine kinase
DOO79_RS01885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOO79_RS01910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOO79_RS01915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DOO79_RS01930	COG0753	catalase activity
DOO79_RS01955	COG2197	response regulator
DOO79_RS01960	COG4585	Histidine kinase
DOO79_RS01965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DOO79_RS01970	COG1136	(ABC) transporter
DOO79_RS01995	COG0697	spore germination
DOO79_RS02010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOO79_RS02015	COG0180	Tryptophanyl-tRNA synthetase
DOO79_RS02020	COG3237	CsbD-like
DOO79_RS02060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DOO79_RS02120	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DOO79_RS02125	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DOO79_RS02125	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DOO79_RS02165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DOO79_RS02185	COG1199	ATP-dependent helicase activity
DOO79_RS02200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DOO79_RS02270	COG0625	glutathione transferase activity
DOO79_RS02310	COG4555	ABC transporter
DOO79_RS02320	COG1476	TRANSCRIPTIONal
DOO79_RS02365	COG0633	Ferredoxin
DOO79_RS02365	COG0543	2 iron, 2 sulfur cluster binding
DOO79_RS02370	COG1131	(ABC) transporter
DOO79_RS02375	COG0842	Transport permease protein
DOO79_RS02385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DOO79_RS02420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOO79_RS02425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOO79_RS02435	COG1042	CoA-binding domain protein
DOO79_RS02435	COG0045	succinate-CoA ligase (ADP-forming) activity
DOO79_RS02435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DOO79_RS02440	COG2239	Acts as a magnesium transporter
DOO79_RS02460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DOO79_RS02465	COG3387	PFAM Glycoside hydrolase 15-related
DOO79_RS02480	COG3100	YcgL domain-containing protein
DOO79_RS02485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DOO79_RS02495	COG0463	Glycosyl transferase, family 2
DOO79_RS02505	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS02545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DOO79_RS02560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DOO79_RS02580	COG4946	Tricorn protease homolog
DOO79_RS02580	COG1506	peptidase
DOO79_RS02580	COG0823	Involved in the tonB-independent uptake of proteins
DOO79_RS02595	COG0408	coproporphyrinogen oxidase activity
DOO79_RS02635	COG0631	protein serine/threonine phosphatase activity
DOO79_RS02825	COG0210	DNA helicase
DOO79_RS02835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOO79_RS02840	COG0583	DNA-binding transcription factor activity
DOO79_RS02845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DOO79_RS02855	COG2159	amidohydrolase
DOO79_RS02880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DOO79_RS02900	COG0357	Ribosomal RNA small subunit methyltransferase G
DOO79_RS02905	COG3540	Alkaline phosphatase
DOO79_RS02915	COG2091	lysine biosynthetic process via aminoadipic acid
DOO79_RS02930	COG0708	Exodeoxyribonuclease III
DOO79_RS02935	COG1846	Transcriptional regulator
DOO79_RS02935	COG1940	carbohydrate kinase activity
DOO79_RS02945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOO79_RS02955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DOO79_RS02960	COG3162	membrane
DOO79_RS02970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DOO79_RS03005	COG3507	Belongs to the glycosyl hydrolase 43 family
DOO79_RS03025	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS03030	COG0179	Fumarylacetoacetate (FAA) hydrolase
DOO79_RS03035	COG4948	Mandelate Racemase Muconate Lactonizing
DOO79_RS03040	COG3254	rhamnose metabolic process
DOO79_RS03045	COG0738	Major facilitator superfamily
DOO79_RS03050	COG1414	Transcriptional regulator
DOO79_RS03055	COG1971	Probably functions as a manganese efflux pump
DOO79_RS03060	COG2205	protein histidine kinase activity
DOO79_RS03070	COG3459	Glycosyltransferase 36 associated
DOO79_RS03075	COG2211	Major facilitator Superfamily
DOO79_RS03080	COG3265	gluconokinase activity
DOO79_RS03105	COG2911	Protein conserved in bacteria
DOO79_RS03110	COG0729	surface antigen
DOO79_RS03170	COG0752	glycyl-tRNA synthetase alpha subunit
DOO79_RS03185	COG0519	Catalyzes the synthesis of GMP from XMP
DOO79_RS03185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DOO79_RS03195	COG0805	protein transport
DOO79_RS03200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DOO79_RS03205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DOO79_RS03215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DOO79_RS03230	COG2974	May be involved in recombination
DOO79_RS03235	COG0037	tRNA processing
DOO79_RS03240	COG2115	Belongs to the xylose isomerase family
DOO79_RS03260	COG4948	Mandelate Racemase Muconate Lactonizing
DOO79_RS03270	COG1472	Belongs to the glycosyl hydrolase 3 family
DOO79_RS03275	COG0246	Mannitol dehydrogenase
DOO79_RS03360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DOO79_RS03405	COG3012	SEC-C Motif Domain Protein
DOO79_RS03405	COG3318	Belongs to the UPF0149 family
DOO79_RS03440	COG0662	Cupin 2, conserved barrel domain protein
DOO79_RS03460	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DOO79_RS03490	COG0714	Associated with various cellular activities
DOO79_RS03530	COG0477	Major facilitator Superfamily
DOO79_RS03535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOO79_RS03585	COG3237	CsbD-like
DOO79_RS03640	COG0564	pseudouridine synthase activity
DOO79_RS03675	COG1309	transcriptional regulator
DOO79_RS03685	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS03735	COG3039	Transposase
DOO79_RS03765	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DOO79_RS03780	COG1127	ABC transporter
DOO79_RS03785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DOO79_RS03790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DOO79_RS03805	COG2853	Lipoprotein
DOO79_RS03815	COG0386	Belongs to the glutathione peroxidase family
DOO79_RS03825	COG1322	Protein conserved in bacteria
DOO79_RS03830	COG0604	alcohol dehydrogenase
DOO79_RS03835	COG0583	DNA-binding transcription factor activity
DOO79_RS03845	COG0625	glutathione transferase activity
DOO79_RS03855	COG0531	amino acid
DOO79_RS03900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DOO79_RS03905	COG0861	Integral membrane protein TerC family
DOO79_RS03915	COG0584	glycerophosphoryl diester phosphodiesterase
DOO79_RS03930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DOO79_RS03935	COG0726	polysaccharide deacetylase
DOO79_RS03940	COG0706	membrane insertase activity
DOO79_RS03945	COG0594	ribonuclease P activity
DOO79_RS03955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DOO79_RS03965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DOO79_RS03970	COG0187	DNA topoisomerase II activity
DOO79_RS03980	COG0501	Belongs to the peptidase M48B family
DOO79_RS04010	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DOO79_RS04020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOO79_RS04075	COG0793	Belongs to the peptidase S41A family
DOO79_RS04080	COG4942	peptidase
DOO79_RS04090	COG2234	aminopeptidase activity
DOO79_RS04100	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DOO79_RS04110	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DOO79_RS04120	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DOO79_RS04125	COG1064	alcohol dehydrogenase
DOO79_RS04130	COG0493	'glutamate synthase
DOO79_RS04135	COG0070	glutamate synthase
DOO79_RS04135	COG0069	glutamate synthase activity
DOO79_RS04135	COG0067	glutamate synthase
DOO79_RS04180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DOO79_RS04210	COG0297	glycogen (starch) synthase activity
DOO79_RS04210	COG0438	transferase activity, transferring glycosyl groups
DOO79_RS04260	COG1132	(ABC) transporter
DOO79_RS04290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DOO79_RS04375	COG1111	helicase
DOO79_RS04375	COG1205	dead DEAH box helicase
DOO79_RS04380	COG1272	protein, Hemolysin III
DOO79_RS04400	COG0300	oxidoreductase activity
DOO79_RS04405	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS04425	COG2249	NAD(P)H dehydrogenase (quinone) activity
DOO79_RS04440	COG1487	ribonuclease activity
DOO79_RS04445	COG4691	Plasmid stability protein
DOO79_RS04465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOO79_RS04475	COG0477	Major facilitator Superfamily
DOO79_RS04480	COG1289	transmembrane transporter activity
DOO79_RS04490	COG1566	PFAM secretion protein HlyD family protein
DOO79_RS04505	COG0302	gtp cyclohydrolase
DOO79_RS04535	COG3012	SEC-C Motif Domain Protein
DOO79_RS04545	COG0676	glucose-6-phosphate 1-epimerase activity
DOO79_RS04565	COG3135	benzoate transporter
DOO79_RS04595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DOO79_RS04610	COG0210	DNA helicase
DOO79_RS04625	COG3132	Protein of unknown function, DUF480
DOO79_RS04630	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DOO79_RS04635	COG0284	orotidine-5'-phosphate decarboxylase activity
DOO79_RS04665	COG2937	Belongs to the GPAT DAPAT family
DOO79_RS04700	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DOO79_RS04780	COG0366	Alpha amylase catalytic
DOO79_RS04785	COG0366	Alpha amylase catalytic
DOO79_RS04790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DOO79_RS04810	COG0657	acetylesterase activity
DOO79_RS04810	COG2755	lipolytic protein G-D-S-L family
DOO79_RS04820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DOO79_RS04835	COG3507	Belongs to the glycosyl hydrolase 43 family
DOO79_RS04840	COG1609	Transcriptional regulator
DOO79_RS04845	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DOO79_RS04850	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS04860	COG2755	lipolytic protein G-D-S-L family
DOO79_RS04875	COG3186	Phenylalanine-4-hydroxylase
DOO79_RS04880	COG1522	sequence-specific DNA binding
DOO79_RS04890	COG1752	Esterase of the alpha-beta hydrolase superfamily
DOO79_RS04900	COG1119	ATPase activity
DOO79_RS04915	COG1125	glycine betaine transport
DOO79_RS04930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DOO79_RS04980	COG0489	protein tyrosine kinase activity
DOO79_RS04985	COG2062	phosphohistidine phosphatase, SixA
DOO79_RS04995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOO79_RS05035	COG1968	undecaprenyl-diphosphatase activity
DOO79_RS05040	COG0174	glutamine synthetase
DOO79_RS05045	COG0347	Belongs to the P(II) protein family
DOO79_RS05050	COG0004	ammonium transporteR
DOO79_RS05055	COG3852	Histidine kinase
DOO79_RS05060	COG2204	response regulator
DOO79_RS05065	COG2032	superoxide dismutase activity
DOO79_RS05070	COG2032	superoxide dismutase activity
DOO79_RS05090	COG0183	Belongs to the thiolase family
DOO79_RS05125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DOO79_RS05130	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DOO79_RS05135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DOO79_RS05190	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DOO79_RS05195	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DOO79_RS05200	COG4786	Flagellar basal body rod
DOO79_RS05205	COG4786	Flagellar basal body rod
DOO79_RS05215	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DOO79_RS05220	COG1706	bacterial-type flagellum-dependent cell motility
DOO79_RS05235	COG1677	Flagellar hook-basal body complex protein FliE
DOO79_RS05240	COG1766	The M ring may be actively involved in energy transduction
DOO79_RS05255	COG1157	protein secretion by the type III secretion system
DOO79_RS05275	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DOO79_RS05310	COG0028	Belongs to the TPP enzyme family
DOO79_RS05315	COG2205	protein histidine kinase activity
DOO79_RS05340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DOO79_RS05355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DOO79_RS05365	COG0596	Alpha beta hydrolase
DOO79_RS05370	COG0727	PFAM Uncharacterised protein family (UPF0153)
DOO79_RS05375	COG0318	PFAM AMP-dependent synthetase and ligase
DOO79_RS05380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOO79_RS05390	COG1181	Belongs to the D-alanine--D-alanine ligase family
DOO79_RS05400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DOO79_RS05410	COG0564	pseudouridine synthase activity
DOO79_RS05435	COG1446	asparaginase
DOO79_RS05440	COG0339	signal peptide processing
DOO79_RS05470	COG0475	glutathione-regulated potassium exporter activity
DOO79_RS05475	COG0583	DNA-binding transcription factor activity
DOO79_RS05480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DOO79_RS05485	COG2224	Isocitrate lyase
DOO79_RS05525	COG4770	biotin carboxylase activity
DOO79_RS05530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DOO79_RS05535	COG1960	acyl-CoA dehydrogenase activity
DOO79_RS05540	COG1309	transcriptional regulator
DOO79_RS05595	COG0523	cobalamin synthesis protein
DOO79_RS05615	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DOO79_RS05620	COG1846	Transcriptional regulator
DOO79_RS05625	COG1764	response to oxidative stress
DOO79_RS05650	COG2130	NADP-dependent
DOO79_RS05665	COG1187	pseudouridine synthase activity
DOO79_RS05680	COG1643	Atp-dependent helicase
DOO79_RS05685	COG4807	Protein conserved in bacteria
DOO79_RS05690	COG2351	hydroxyisourate hydrolase activity
DOO79_RS05695	COG2072	flavoprotein involved in K transport
DOO79_RS05715	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DOO79_RS05750	COG1957	nucleoside hydrolase
DOO79_RS05760	COG2252	PERMEase
DOO79_RS05780	COG0084	hydrolase, TatD family'
DOO79_RS05805	COG2814	Major facilitator Superfamily
DOO79_RS05820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DOO79_RS05825	COG1902	pentaerythritol trinitrate reductase activity
DOO79_RS05845	COG0745	RESPONSE REGULATOR receiver
DOO79_RS05850	COG2205	protein histidine kinase activity
DOO79_RS05855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DOO79_RS05880	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DOO79_RS05885	COG0583	DNA-binding transcription factor activity
DOO79_RS05915	COG0702	epimerase
DOO79_RS05920	COG1733	regulation of RNA biosynthetic process
DOO79_RS06040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DOO79_RS06045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DOO79_RS06070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DOO79_RS06075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DOO79_RS06085	COG3485	protocatechuate 3,4-dioxygenase
DOO79_RS06100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DOO79_RS06105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DOO79_RS06115	COG1414	Transcriptional regulator
DOO79_RS06125	COG0657	acetylesterase activity
DOO79_RS06135	COG0445	tRNA wobble uridine modification
DOO79_RS06145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DOO79_RS06175	COG2267	carboxylic ester hydrolase activity
DOO79_RS06185	COG0156	8-amino-7-oxononanoate synthase activity
DOO79_RS06190	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DOO79_RS06195	COG1040	competence protein
DOO79_RS06200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DOO79_RS06285	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DOO79_RS06355	COG3264	Mechanosensitive ion channel
DOO79_RS06355	COG1511	domain protein
DOO79_RS06360	COG1368	sulfuric ester hydrolase activity
DOO79_RS06365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DOO79_RS06370	COG2354	Protein conserved in bacteria
DOO79_RS06380	COG0297	glycogen (starch) synthase activity
DOO79_RS06385	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DOO79_RS06390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DOO79_RS06415	COG0702	epimerase
DOO79_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS06455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DOO79_RS06460	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS06470	COG0513	Belongs to the DEAD box helicase family
DOO79_RS06495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DOO79_RS06505	COG3483	tryptophan 2,3-dioxygenase activity
DOO79_RS06510	COG3104	oligopeptide transport
DOO79_RS06535	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DOO79_RS06550	COG1320	monovalent cation:proton antiporter activity
DOO79_RS06555	COG2212	antiporter activity
DOO79_RS06565	COG0651	ATP synthesis coupled electron transport
DOO79_RS06570	COG1006	Multisubunit Na H antiporter MnhC subunit
DOO79_RS06575	COG2111	Na H antiporter
DOO79_RS06575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DOO79_RS06595	COG3179	chitinase
DOO79_RS06615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DOO79_RS06620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DOO79_RS06635	COG0456	acetyltransferase
DOO79_RS06640	COG1597	lipid kinase activity
DOO79_RS06665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DOO79_RS06670	COG0134	indole-3-glycerol-phosphate synthase activity
DOO79_RS06680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOO79_RS06685	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DOO79_RS06695	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DOO79_RS06705	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DOO79_RS06720	COG1051	belongs to the nudix hydrolase family
DOO79_RS06760	COG0316	Belongs to the HesB IscA family
DOO79_RS06775	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DOO79_RS06790	COG2814	Major facilitator Superfamily
DOO79_RS06800	COG2814	Major facilitator Superfamily
DOO79_RS06805	COG1289	transmembrane transporter activity
DOO79_RS06815	COG0151	Belongs to the GarS family
DOO79_RS06825	COG0138	bifunctional purine biosynthesis protein purh
DOO79_RS06830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DOO79_RS06835	COG2267	carboxylic ester hydrolase activity
DOO79_RS06840	COG2453	phosphatase
DOO79_RS06840	COG0671	phosphoesterase, PA-phosphatase related
DOO79_RS06865	COG4589	Belongs to the CDS family
DOO79_RS06870	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DOO79_RS06890	COG2264	protein methyltransferase activity
DOO79_RS06905	COG0439	Biotin carboxylase
DOO79_RS06915	COG0511	ligase activity, forming carbon-carbon bonds
DOO79_RS06920	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DOO79_RS06930	COG1324	tolerance protein
DOO79_RS06955	COG0300	oxidoreductase activity
DOO79_RS06965	COG2356	endonuclease I
DOO79_RS06975	COG0459	protein refolding
DOO79_RS06990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DOO79_RS07005	COG3386	PFAM SMP-30 Gluconolaconase
DOO79_RS07020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DOO79_RS07035	COG0778	Nitroreductase
DOO79_RS07040	COG2353	YceI-like domain
DOO79_RS07070	COG3052	prosthetic group binding
DOO79_RS07105	COG1802	Transcriptional regulator
DOO79_RS07180	COG4221	oxidoreductase activity
DOO79_RS07195	COG4221	oxidoreductase activity
DOO79_RS07205	COG0435	Glutathione S-transferase
DOO79_RS07230	COG2409	Drug exporters of the RND superfamily
DOO79_RS07240	COG1506	peptidase
DOO79_RS07240	COG0823	Involved in the tonB-independent uptake of proteins
DOO79_RS07275	COG0697	spore germination
DOO79_RS07290	COG1113	amino acid transport
DOO79_RS07310	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DOO79_RS07355	COG5001	Diguanylate cyclase
DOO79_RS07365	COG0840	transmembrane signaling receptor activity
DOO79_RS07370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DOO79_RS07370	COG5297	Belongs to the glycosyl hydrolase family 6
DOO79_RS07375	COG0659	secondary active sulfate transmembrane transporter activity
DOO79_RS07390	COG2943	transferase activity, transferring hexosyl groups
DOO79_RS07400	COG3275	phosphorelay sensor kinase activity
DOO79_RS07410	COG0181	hydroxymethylbilane synthase activity
DOO79_RS07445	COG1505	serine-type exopeptidase activity
DOO79_RS07455	COG0436	Aminotransferase
DOO79_RS07465	COG2832	Protein of unknown function (DUF454)
DOO79_RS07475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DOO79_RS07485	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DOO79_RS07490	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DOO79_RS07495	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DOO79_RS07520	COG2226	methyltransferase
DOO79_RS07525	COG5001	Diguanylate cyclase
DOO79_RS07525	COG3300	MHYT domain
DOO79_RS07530	COG0308	aminopeptidase N
DOO79_RS07560	COG1162	GTPase activity
DOO79_RS07585	COG2211	Major facilitator Superfamily
DOO79_RS07590	COG1609	Transcriptional regulator
DOO79_RS07595	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS07600	COG2851	Citrate transporter
DOO79_RS07615	COG0642	Histidine kinase
DOO79_RS07625	COG2197	response regulator
DOO79_RS07645	COG0667	Aldo Keto reductase
DOO79_RS07650	COG0583	DNA-binding transcription factor activity
DOO79_RS07680	COG1301	dicarboxylic acid transport
DOO79_RS07685	COG0281	malic enzyme
DOO79_RS07685	COG0280	phosphate acetyltransferase
DOO79_RS07710	COG1560	Kdo2-lipid A biosynthetic process
DOO79_RS07715	COG1519	Transferase
DOO79_RS07720	COG1538	Outer membrane efflux protein
DOO79_RS07725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DOO79_RS07745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DOO79_RS07750	COG0066	3-isopropylmalate dehydratase activity
DOO79_RS07755	COG0473	3-isopropylmalate dehydrogenase activity
DOO79_RS07760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DOO79_RS07780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DOO79_RS07790	COG0840	transmembrane signaling receptor activity
DOO79_RS07800	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DOO79_RS07805	COG3710	Transcriptional regulator
DOO79_RS07835	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DOO79_RS07845	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DOO79_RS07870	COG0563	adenylate kinase activity
DOO79_RS07875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DOO79_RS07885	COG3781	membrane
DOO79_RS07890	COG0671	phosphoesterase, PA-phosphatase related
DOO79_RS07900	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS07910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOO79_RS07915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DOO79_RS07945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DOO79_RS07960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DOO79_RS07970	COG0352	thiamine-phosphate diphosphorylase activity
DOO79_RS07975	COG1773	rubredoxin
DOO79_RS07980	COG2912	Transglutaminase-like superfamily
DOO79_RS07990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DOO79_RS08000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DOO79_RS08020	COG3079	Belongs to the UPF0149 family
DOO79_RS08025	COG0006	proline dipeptidase activity
DOO79_RS08035	COG0006	proline dipeptidase activity
DOO79_RS08050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DOO79_RS08055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DOO79_RS08065	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DOO79_RS08070	COG1561	YicC-like family, N-terminal region
DOO79_RS08075	COG0194	GDP metabolic process
DOO79_RS08085	COG1070	Carbohydrate kinase
DOO79_RS08090	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS08110	COG3659	wide pore channel activity
DOO79_RS08125	COG2390	Transcriptional regulator
DOO79_RS08130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOO79_RS08135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DOO79_RS08145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DOO79_RS08175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DOO79_RS08205	COG0714	Associated with various cellular activities
DOO79_RS08225	COG2304	oxidoreductase activity
DOO79_RS08235	COG1301	dicarboxylic acid transport
DOO79_RS08240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DOO79_RS08245	COG0596	Alpha beta hydrolase
DOO79_RS08250	COG4773	Receptor
DOO79_RS08260	COG0739	heme binding
DOO79_RS08270	COG1376	ErfK ybiS ycfS ynhG family protein
DOO79_RS08305	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DOO79_RS08310	COG4149	molybdate abc transporter
DOO79_RS08315	COG0725	ABC transporter, periplasmic molybdate-binding protein
DOO79_RS08320	COG3453	Protein conserved in bacteria
DOO79_RS08320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOO79_RS08330	COG3047	cAMP biosynthetic process
DOO79_RS08335	COG3047	cAMP biosynthetic process
DOO79_RS08350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DOO79_RS08370	COG0126	phosphoglycerate kinase activity
DOO79_RS08380	COG0469	pyruvate kinase activity
DOO79_RS08385	COG3588	fructose-bisphosphate aldolase
DOO79_RS08390	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DOO79_RS08420	COG2198	Histidine kinase
DOO79_RS08420	COG2205	protein histidine kinase activity
DOO79_RS08420	COG0784	Response regulator, receiver
DOO79_RS08440	COG0175	sulfate reduction
DOO79_RS08445	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DOO79_RS08450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DOO79_RS08455	COG0175	sulfate reduction
DOO79_RS08460	COG2895	sulfate adenylyltransferase (ATP) activity
DOO79_RS08460	COG0529	Catalyzes the synthesis of activated sulfate
DOO79_RS08465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DOO79_RS08470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DOO79_RS08520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DOO79_RS08535	COG4948	Mandelate Racemase Muconate Lactonizing
DOO79_RS08540	COG3250	beta-galactosidase activity
DOO79_RS08550	COG1609	Transcriptional regulator
DOO79_RS08560	COG1970	mechanosensitive ion channel activity
DOO79_RS08580	COG3273	potassium ion transport
DOO79_RS08580	COG0471	metal ion transport
DOO79_RS08585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DOO79_RS08590	COG2022	thiamine diphosphate biosynthetic process
DOO79_RS08635	COG0189	ligase activity
DOO79_RS08645	COG0745	RESPONSE REGULATOR receiver
DOO79_RS08650	COG5002	protein histidine kinase activity
DOO79_RS08760	COG2010	Cytochrome c
DOO79_RS08780	COG3284	Transcriptional regulator
DOO79_RS08785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOO79_RS08790	COG1077	Cell shape determining protein MreB Mrl
DOO79_RS08795	COG1792	Involved in formation and maintenance of cell shape
DOO79_RS08810	COG0772	Belongs to the SEDS family
DOO79_RS08820	COG2951	lytic endotransglycosylase activity
DOO79_RS08825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DOO79_RS08830	COG1686	Belongs to the peptidase S11 family
DOO79_RS08840	COG2921	Belongs to the UPF0250 family
DOO79_RS08845	COG0321	lipoyl(octanoyl) transferase activity
DOO79_RS08850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DOO79_RS08865	COG0583	DNA-binding transcription factor activity
DOO79_RS08875	COG1051	belongs to the nudix hydrolase family
DOO79_RS08875	COG1056	cytidyltransferase-related domain
DOO79_RS08910	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DOO79_RS08915	COG0673	inositol 2-dehydrogenase activity
DOO79_RS08920	COG2823	Periplasmic or secreted lipoprotein
DOO79_RS08925	COG4251	negative regulation of phosphorylation
DOO79_RS08930	COG0784	Response regulator, receiver
DOO79_RS08935	COG4191	Histidine kinase
DOO79_RS08940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DOO79_RS08995	COG1459	type II secretion system
DOO79_RS09015	COG4795	General secretion pathway protein
DOO79_RS09045	COG3250	beta-galactosidase activity
DOO79_RS09060	COG2188	Transcriptional regulator
DOO79_RS09070	COG1609	Transcriptional regulator
DOO79_RS09075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DOO79_RS09080	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DOO79_RS09090	COG0617	tRNA 3'-terminal CCA addition
DOO79_RS09095	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DOO79_RS09100	COG1012	belongs to the aldehyde dehydrogenase family
DOO79_RS09105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DOO79_RS09120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DOO79_RS09135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DOO79_RS09140	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DOO79_RS09155	COG2205	protein histidine kinase activity
DOO79_RS09180	COG3791	Glutathione-dependent formaldehyde-activating
DOO79_RS09195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DOO79_RS09205	COG0697	spore germination
DOO79_RS09215	COG0488	(ABC) transporter
DOO79_RS09225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DOO79_RS09230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DOO79_RS09240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DOO79_RS09240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DOO79_RS09260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DOO79_RS09265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DOO79_RS09270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DOO79_RS09290	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DOO79_RS09295	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DOO79_RS09300	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DOO79_RS09305	COG2205	protein histidine kinase activity
DOO79_RS09310	COG0745	RESPONSE REGULATOR receiver
DOO79_RS09345	COG0277	FAD linked oxidase domain protein
DOO79_RS09350	COG1988	membrane-bound metal-dependent
DOO79_RS09355	COG0792	nuclease activity
DOO79_RS09395	COG0275	rRNA processing
DOO79_RS09400	COG3116	cell division
DOO79_RS09410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DOO79_RS09415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DOO79_RS09420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DOO79_RS09430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DOO79_RS09435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DOO79_RS09440	COG1181	Belongs to the D-alanine--D-alanine ligase family
DOO79_RS09445	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DOO79_RS09460	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DOO79_RS09475	COG0653	protein targeting
DOO79_RS09480	COG0494	nUDIX hydrolase
DOO79_RS09490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DOO79_RS09500	COG0604	alcohol dehydrogenase
DOO79_RS09500	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS09500	COG3321	synthase
DOO79_RS09525	COG0366	Alpha amylase catalytic
DOO79_RS09555	COG2226	methyltransferase
DOO79_RS09560	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DOO79_RS09570	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DOO79_RS09620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DOO79_RS09630	COG4106	trans-aconitate 2-methyltransferase activity
DOO79_RS09635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DOO79_RS09645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOO79_RS09650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DOO79_RS09655	COG0667	Aldo Keto reductase
DOO79_RS09665	COG4771	TonB-dependent receptor
DOO79_RS09685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOO79_RS09690	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DOO79_RS09700	COG2175	clavaminate synthase activity
DOO79_RS09710	COG4181	ATPase activity
DOO79_RS09725	COG0642	Histidine kinase
DOO79_RS09745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DOO79_RS09760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOO79_RS09765	COG2201	protein-glutamate methylesterase activity
DOO79_RS09770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DOO79_RS09775	COG2202	Pas domain
DOO79_RS09775	COG2199	diguanylate cyclase activity
DOO79_RS09775	COG2200	EAL domain
DOO79_RS09780	COG0835	chemotaxis
DOO79_RS09785	COG0840	transmembrane signaling receptor activity
DOO79_RS09790	COG2198	Histidine kinase
DOO79_RS09790	COG0643	Histidine kinase
DOO79_RS09800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DOO79_RS09810	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DOO79_RS09820	COG2205	protein histidine kinase activity
DOO79_RS09825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DOO79_RS09835	COG4452	Inner membrane protein CreD
DOO79_RS09860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DOO79_RS09865	COG0735	belongs to the Fur family
DOO79_RS09880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DOO79_RS09900	COG2207	Transcriptional regulator
DOO79_RS09910	COG0583	DNA-binding transcription factor activity
DOO79_RS09915	COG2814	Major facilitator Superfamily
DOO79_RS10000	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DOO79_RS10050	COG5001	Diguanylate cyclase
DOO79_RS10050	COG5002	protein histidine kinase activity
DOO79_RS10055	COG1187	pseudouridine synthase activity
DOO79_RS10075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DOO79_RS10085	COG0475	glutathione-regulated potassium exporter activity
DOO79_RS10090	COG5002	protein histidine kinase activity
DOO79_RS10090	COG5000	phosphorelay sensor kinase activity
DOO79_RS10095	COG0745	RESPONSE REGULATOR receiver
DOO79_RS10100	COG1538	Outer membrane efflux protein
DOO79_RS10130	COG1132	(ABC) transporter
DOO79_RS10175	COG2155	Conserved Protein
DOO79_RS10205	COG3118	belongs to the thioredoxin family
DOO79_RS10230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DOO79_RS10245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DOO79_RS10265	COG2968	Membrane
DOO79_RS10270	COG0424	maF-like protein
DOO79_RS10280	COG3164	Protein of unknown function
DOO79_RS10290	COG0312	modulator of DNA gyrase
DOO79_RS10295	COG3028	Belongs to the UPF0307 family
DOO79_RS10300	COG0312	modulator of DNA gyrase
DOO79_RS10315	COG3012	SEC-C Motif Domain Protein
DOO79_RS10315	COG3318	Belongs to the UPF0149 family
DOO79_RS10345	COG0142	geranyltranstransferase activity
DOO79_RS10350	COG1722	exodeoxyribonuclease VII activity
DOO79_RS10355	COG0037	tRNA processing
DOO79_RS10360	COG1785	Belongs to the alkaline phosphatase family
DOO79_RS10365	COG1301	dicarboxylic acid transport
DOO79_RS10370	COG4106	trans-aconitate 2-methyltransferase activity
DOO79_RS10380	COG0791	NLP P60 protein
DOO79_RS10385	COG0791	NLP P60 protein
DOO79_RS10390	COG1047	Peptidyl-prolyl cis-trans
DOO79_RS10395	COG2311	Membrane
DOO79_RS10400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DOO79_RS10405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DOO79_RS10430	COG3590	peptidase
DOO79_RS10435	COG3590	peptidase
DOO79_RS10500	COG3209	COG3209 Rhs family protein
DOO79_RS10555	COG3250	beta-galactosidase activity
DOO79_RS10560	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DOO79_RS10580	COG1960	acyl-CoA dehydrogenase activity
DOO79_RS10585	COG1024	Enoyl-CoA hydratase
DOO79_RS10620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOO79_RS10625	COG0481	GTPase activity
DOO79_RS10640	COG0571	ribonuclease III activity
DOO79_RS10645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DOO79_RS10650	COG1381	Involved in DNA repair and RecF pathway recombination
DOO79_RS10660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DOO79_RS10670	COG2954	triphosphatase activity
DOO79_RS10675	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DOO79_RS10680	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DOO79_RS10685	COG3046	protein related to deoxyribodipyrimidine photolyase
DOO79_RS10690	COG1472	Belongs to the glycosyl hydrolase 3 family
DOO79_RS10695	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DOO79_RS10700	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DOO79_RS10710	COG1278	Cold shock
DOO79_RS10725	COG1201	RNA secondary structure unwinding
DOO79_RS10730	COG1793	dna ligase
DOO79_RS10740	COG1793	dna ligase
DOO79_RS10740	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DOO79_RS10770	COG0183	Belongs to the thiolase family
DOO79_RS10795	COG1451	nucleotide metabolic process
DOO79_RS10800	COG5487	UPF0391 membrane protein
DOO79_RS10810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DOO79_RS10830	COG1047	Peptidyl-prolyl cis-trans
DOO79_RS10840	COG2824	Alkylphosphonate utilization operon protein PhnA
DOO79_RS10850	COG2814	Major facilitator Superfamily
DOO79_RS10885	COG0392	lysyltransferase activity
DOO79_RS10885	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DOO79_RS10895	COG0251	oxidation-reduction process
DOO79_RS10900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DOO79_RS10915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DOO79_RS10940	COG1595	DNA-templated transcription, initiation
DOO79_RS10955	COG2878	Part of a membrane complex involved in electron transport
DOO79_RS10965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOO79_RS10965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOO79_RS10980	COG1131	(ABC) transporter
DOO79_RS10985	COG0346	lactoylglutathione lyase activity
DOO79_RS10990	COG0833	amino acid
DOO79_RS10995	COG2040	homocysteine
DOO79_RS11005	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DOO79_RS11025	COG1695	Transcriptional regulator
DOO79_RS11045	COG1981	membrane
DOO79_RS11060	COG0825	malonyl-CoA metabolic process
DOO79_RS11070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DOO79_RS11075	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DOO79_RS11080	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DOO79_RS11085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DOO79_RS11090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DOO79_RS11105	COG0750	zinc metalloprotease
DOO79_RS11110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DOO79_RS11115	COG0575	Belongs to the CDS family
DOO79_RS11120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DOO79_RS11125	COG0233	cytoplasmic translational termination
DOO79_RS11130	COG0528	UMP kinase activity
DOO79_RS11140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DOO79_RS11145	COG0052	Belongs to the universal ribosomal protein uS2 family
DOO79_RS11185	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DOO79_RS11195	COG1393	Belongs to the ArsC family
DOO79_RS11200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DOO79_RS11205	COG0367	asparagine synthase
DOO79_RS11215	COG4774	siderophore transport
DOO79_RS11255	COG1566	PFAM secretion protein HlyD family protein
DOO79_RS11260	COG2814	Major facilitator Superfamily
DOO79_RS11315	COG0339	signal peptide processing
DOO79_RS11320	COG0386	Belongs to the glutathione peroxidase family
DOO79_RS11380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DOO79_RS11385	COG0084	hydrolase, TatD family'
DOO79_RS11400	COG1960	acyl-CoA dehydrogenase activity
DOO79_RS11420	COG0367	asparagine synthase
DOO79_RS11430	COG0305	Participates in initiation and elongation during chromosome replication
DOO79_RS11435	COG0415	Belongs to the DNA photolyase family
DOO79_RS11445	COG0583	DNA-binding transcription factor activity
DOO79_RS11490	COG3706	GGDEF domain
DOO79_RS11515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DOO79_RS11530	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DOO79_RS11540	COG0497	DNA recombination
DOO79_RS11545	COG1420	regulation of RNA biosynthetic process
DOO79_RS11550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DOO79_RS11555	COG0443	Heat shock 70 kDa protein
DOO79_RS11560	COG0484	heat shock protein binding
DOO79_RS11600	COG0583	DNA-binding transcription factor activity
DOO79_RS11605	COG1132	(ABC) transporter
DOO79_RS11640	COG2850	peptidyl-arginine hydroxylation
DOO79_RS11660	COG1253	flavin adenine dinucleotide binding
DOO79_RS11690	COG1131	(ABC) transporter
DOO79_RS11695	COG1725	Transcriptional regulator
DOO79_RS11705	COG0386	Belongs to the glutathione peroxidase family
DOO79_RS11720	COG2900	Belongs to the SlyX family
DOO79_RS11745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOO79_RS11770	COG0646	methionine synthase
DOO79_RS11770	COG1410	methionine synthase
DOO79_RS11775	COG2226	methyltransferase
DOO79_RS11780	COG1960	acyl-CoA dehydrogenase activity
DOO79_RS11785	COG1960	acyl-CoA dehydrogenase activity
DOO79_RS11800	COG0557	exoribonuclease II activity
DOO79_RS11810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DOO79_RS11820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DOO79_RS11830	COG0704	Plays a role in the regulation of phosphate uptake
DOO79_RS11835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DOO79_RS11840	COG0581	inorganic phosphate transmembrane transporter activity
DOO79_RS11845	COG0573	inorganic phosphate transmembrane transporter activity
DOO79_RS11850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DOO79_RS11875	COG0659	secondary active sulfate transmembrane transporter activity
DOO79_RS11880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DOO79_RS11890	COG1024	Enoyl-CoA hydratase
DOO79_RS11900	COG0494	nUDIX hydrolase
DOO79_RS11950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DOO79_RS11975	COG2925	Exonuclease
DOO79_RS11985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DOO79_RS11990	COG3844	kynureninase activity
DOO79_RS12000	COG0662	Cupin 2, conserved barrel domain protein
DOO79_RS12005	COG0288	reversible hydration of carbon dioxide
DOO79_RS12070	COG2808	Putative FMN-binding domain
DOO79_RS12090	COG0017	Asparaginyl-tRNA synthetase
DOO79_RS12095	COG0316	Belongs to the HesB IscA family
DOO79_RS12100	COG0360	Binds together with S18 to 16S ribosomal RNA
DOO79_RS12105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DOO79_RS12110	COG0359	binds to the 23S rRNA
DOO79_RS12120	COG3115	cell septum assembly
DOO79_RS12130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DOO79_RS12135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DOO79_RS12140	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DOO79_RS12150	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DOO79_RS12160	COG4993	Dehydrogenase
DOO79_RS12170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DOO79_RS12180	COG2986	histidine ammonia-lyase
DOO79_RS12185	COG1228	amidohydrolase
DOO79_RS12225	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DOO79_RS12230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DOO79_RS12235	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DOO79_RS12240	COG0077	Prephenate dehydratase
DOO79_RS12240	COG1605	Chorismate mutase
DOO79_RS12245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DOO79_RS12260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DOO79_RS12265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DOO79_RS12270	COG0583	DNA-binding transcription factor activity
DOO79_RS12300	COG0840	transmembrane signaling receptor activity
DOO79_RS12325	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DOO79_RS12330	COG0784	Response regulator, receiver
DOO79_RS12330	COG4191	Histidine kinase
DOO79_RS12345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOO79_RS12355	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DOO79_RS12365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DOO79_RS12380	COG1595	DNA-templated transcription, initiation
DOO79_RS12430	COG2244	polysaccharide biosynthetic process
DOO79_RS12460	COG2264	protein methyltransferase activity
DOO79_RS12485	COG1136	(ABC) transporter
DOO79_RS12490	COG1132	(ABC) transporter
DOO79_RS12495	COG0477	Major facilitator Superfamily
DOO79_RS12500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DOO79_RS12515	COG1253	flavin adenine dinucleotide binding
DOO79_RS12525	COG0306	phosphate transporter
DOO79_RS12550	COG0504	CTP synthase activity
DOO79_RS12555	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DOO79_RS12565	COG0148	phosphopyruvate hydratase activity
DOO79_RS12570	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DOO79_RS12575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DOO79_RS12580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DOO79_RS12585	COG0585	pseudouridine synthase activity
DOO79_RS12590	COG2840	Smr protein MutS2
DOO79_RS12595	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DOO79_RS12600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DOO79_RS12605	COG1238	metal cluster binding
DOO79_RS12620	COG1534	Rna-binding protein
DOO79_RS12625	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DOO79_RS12635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DOO79_RS12640	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DOO79_RS12650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DOO79_RS12655	COG1546	Belongs to the CinA family
DOO79_RS12665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DOO79_RS12670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DOO79_RS12675	COG2137	regulation of response to DNA damage stimulus
DOO79_RS12680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DOO79_RS12685	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DOO79_RS12700	COG1741	Belongs to the pirin family
DOO79_RS12705	COG0583	DNA-binding transcription factor activity
DOO79_RS12730	COG0351	phosphomethylpyrimidine kinase
DOO79_RS12745	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DOO79_RS12750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DOO79_RS12765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DOO79_RS12775	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DOO79_RS12780	COG3734	2-keto-3-deoxy-galactonokinase
DOO79_RS12790	COG4948	Mandelate Racemase Muconate Lactonizing
DOO79_RS12795	COG0800	Aldolase
DOO79_RS12830	COG1501	Belongs to the glycosyl hydrolase 31 family
DOO79_RS12840	COG1070	Carbohydrate kinase
DOO79_RS12845	COG2115	Belongs to the xylose isomerase family
DOO79_RS12850	COG0477	Major facilitator Superfamily
DOO79_RS12865	COG0860	N-Acetylmuramoyl-L-alanine amidase
DOO79_RS12870	COG1469	GTP cyclohydrolase I activity
DOO79_RS12890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DOO79_RS12895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DOO79_RS12900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DOO79_RS12905	COG0166	Belongs to the GPI family
DOO79_RS12925	COG1472	Belongs to the glycosyl hydrolase 3 family
DOO79_RS12935	COG3706	GGDEF domain
DOO79_RS12935	COG4251	negative regulation of phosphorylation
DOO79_RS12935	COG5001	Diguanylate cyclase
DOO79_RS12935	COG2203	Gaf domain
DOO79_RS12940	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DOO79_RS12945	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DOO79_RS12960	COG0671	phosphoesterase, PA-phosphatase related
DOO79_RS12990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DOO79_RS12995	COG0167	dihydroorotate dehydrogenase activity
DOO79_RS13010	COG1012	belongs to the aldehyde dehydrogenase family
DOO79_RS13040	COG0326	Molecular chaperone. Has ATPase activity
DOO79_RS13045	COG0742	ribosomal rna small subunit methyltransferase
DOO79_RS13050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DOO79_RS13060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DOO79_RS13065	COG0405	Gamma-glutamyltransferase
DOO79_RS13070	COG3291	Pkd domain containing protein
DOO79_RS13075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DOO79_RS13110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DOO79_RS13115	COG0343	queuine tRNA-ribosyltransferase activity
DOO79_RS13120	COG1862	Preprotein translocase
DOO79_RS13130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DOO79_RS13165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DOO79_RS13165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DOO79_RS13170	COG1105	Belongs to the carbohydrate kinase PfkB family
DOO79_RS13175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DOO79_RS13175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOO79_RS13180	COG1609	Transcriptional regulator
DOO79_RS13190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DOO79_RS13195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DOO79_RS13205	COG2902	Dehydrogenase
DOO79_RS13240	COG1238	metal cluster binding
DOO79_RS13260	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS13290	COG2226	methyltransferase
DOO79_RS13290	COG1073	alpha beta
DOO79_RS13380	COG0316	Belongs to the HesB IscA family
DOO79_RS13380	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DOO79_RS13385	COG2154	pterin-4-alpha-carbinolamine dehydratase
DOO79_RS13395	COG0428	transporter
DOO79_RS13400	COG3064	Membrane
DOO79_RS13410	COG1530	ribonuclease E activity
DOO79_RS13420	COG1054	Belongs to the UPF0176 family
DOO79_RS13440	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DOO79_RS13470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DOO79_RS13550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DOO79_RS13555	COG0322	excinuclease ABC activity
DOO79_RS13565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DOO79_RS13570	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DOO79_RS13575	COG1663	tetraacyldisaccharide 4'-kinase activity
DOO79_RS13580	COG1132	(ABC) transporter
DOO79_RS13590	COG0811	peptide transport
DOO79_RS13605	COG1136	(ABC) transporter
DOO79_RS13610	COG4591	ABC-type transport system involved in lipoprotein release permease component
DOO79_RS13620	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DOO79_RS13640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DOO79_RS13665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DOO79_RS13670	COG0837	glucose binding
DOO79_RS13675	COG0363	glucosamine-6-phosphate deaminase activity
DOO79_RS13680	COG0129	dihydroxy-acid dehydratase activity
DOO79_RS13685	COG0800	Aldolase
DOO79_RS13750	COG2205	protein histidine kinase activity
DOO79_RS13750	COG0784	Response regulator, receiver
DOO79_RS13755	COG2183	response to ionizing radiation
DOO79_RS13765	COG0723	plastoquinol--plastocyanin reductase activity
DOO79_RS13765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DOO79_RS13780	COG3243	poly(R)-hydroxyalkanoic acid synthase
DOO79_RS13790	COG1183	phosphatidylcholine synthase activity
DOO79_RS13795	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS13810	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DOO79_RS13820	COG0668	transmembrane transport
DOO79_RS13835	COG4456	Virulence-associated protein
DOO79_RS13900	COG3318	Belongs to the UPF0149 family
DOO79_RS13900	COG3012	SEC-C Motif Domain Protein
DOO79_RS13920	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DOO79_RS13945	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DOO79_RS13960	COG1914	H( )-stimulated, divalent metal cation uptake system
DOO79_RS13980	COG2814	Major facilitator Superfamily
DOO79_RS14005	COG1335	isochorismatase
DOO79_RS14025	COG2197	response regulator
DOO79_RS14045	COG0583	DNA-binding transcription factor activity
DOO79_RS14050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DOO79_RS14055	COG3002	Belongs to the UPF0753 family
DOO79_RS14060	COG0519	Catalyzes the synthesis of GMP from XMP
DOO79_RS14060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DOO79_RS14070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DOO79_RS14080	COG0475	glutathione-regulated potassium exporter activity
DOO79_RS14080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DOO79_RS14085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DOO79_RS14095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DOO79_RS14100	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DOO79_RS14110	COG0776	regulation of translation
DOO79_RS14115	COG0539	negative regulation of cytoplasmic translation
DOO79_RS14120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DOO79_RS14135	COG2957	Belongs to the agmatine deiminase family
DOO79_RS14140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DOO79_RS14165	COG0395	ABC-type sugar transport system, permease component
DOO79_RS14170	COG1175	transmembrane transport
DOO79_RS14200	COG2350	Protein conserved in bacteria
DOO79_RS14205	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DOO79_RS14210	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DOO79_RS14215	COG1187	pseudouridine synthase activity
DOO79_RS14235	COG0436	Aminotransferase
DOO79_RS14240	COG4133	protoheme IX ABC transporter activity
DOO79_RS14260	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DOO79_RS14265	COG1138	Cytochrome C-type biogenesis protein
DOO79_RS14285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DOO79_RS14290	COG1278	Cold shock
DOO79_RS14295	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DOO79_RS14300	COG4988	ABC transporter
DOO79_RS14310	COG1294	oxidase, subunit
DOO79_RS14320	COG3344	reverse transcriptase
DOO79_RS14340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DOO79_RS14345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DOO79_RS14355	COG0165	Argininosuccinate lyase
DOO79_RS14360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DOO79_RS14370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DOO79_RS14375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DOO79_RS14385	COG0137	argininosuccinate synthase activity
DOO79_RS14390	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DOO79_RS14400	COG0215	cysteine-tRNA ligase activity
DOO79_RS14405	COG2166	iron-sulfur cluster assembly
DOO79_RS14420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DOO79_RS14425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DOO79_RS14455	COG4302	ethanolamine ammonia-lyase activity
DOO79_RS14515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DOO79_RS14520	COG0402	S-adenosylhomocysteine deaminase activity
DOO79_RS14530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DOO79_RS14535	COG1509	lysine 2,3-aminomutase activity
DOO79_RS14540	COG5001	Diguanylate cyclase
DOO79_RS14540	COG3300	MHYT domain
DOO79_RS14555	COG0483	inositol monophosphate 1-phosphatase activity
DOO79_RS14560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DOO79_RS14575	COG0488	(ABC) transporter
DOO79_RS14580	COG0513	Belongs to the DEAD box helicase family
DOO79_RS14585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DOO79_RS14590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DOO79_RS14600	COG0625	glutathione transferase activity
DOO79_RS14610	COG4681	YaeQ
DOO79_RS14615	COG2081	HI0933 family
DOO79_RS14660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DOO79_RS14665	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS14690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DOO79_RS14695	COG0860	N-Acetylmuramoyl-L-alanine amidase
DOO79_RS14700	COG0802	atpase or kinase
DOO79_RS14705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DOO79_RS14705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DOO79_RS14710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DOO79_RS14715	COG1570	exodeoxyribonuclease VII activity
DOO79_RS14725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DOO79_RS14770	COG0835	chemotaxis
DOO79_RS14775	COG0840	transmembrane signaling receptor activity
DOO79_RS14780	COG2094	Belongs to the DNA glycosylase MPG family
DOO79_RS14785	COG1201	RNA secondary structure unwinding
DOO79_RS14805	COG2969	positive regulation of protein catabolic process
DOO79_RS14810	COG0625	glutathione transferase activity
DOO79_RS14815	COG2857	Cytochrome c1
DOO79_RS14820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DOO79_RS14830	COG0741	lytic transglycosylase activity
DOO79_RS14845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DOO79_RS14850	COG1702	phosphate starvation-inducible protein PhoH
DOO79_RS14860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DOO79_RS14870	COG4535	Mg2 and Co2 transporter CorC
DOO79_RS14885	COG1012	belongs to the aldehyde dehydrogenase family
DOO79_RS14890	COG1177	transmembrane transport
DOO79_RS14895	COG1176	ABC-type spermidine putrescine transport system, permease component I
DOO79_RS14900	COG3842	ATPase activity
DOO79_RS14920	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DOO79_RS14935	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DOO79_RS14940	COG0174	glutamine synthetase
DOO79_RS14945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DOO79_RS14955	COG2703	oxygen carrier activity
DOO79_RS14960	COG0477	Major facilitator Superfamily
DOO79_RS14970	COG0243	molybdopterin cofactor binding
DOO79_RS14975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DOO79_RS14980	COG2223	nitrite transmembrane transporter activity
DOO79_RS14985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DOO79_RS14995	COG2733	membrane
DOO79_RS15000	COG2205	protein histidine kinase activity
DOO79_RS15000	COG0784	Response regulator, receiver
DOO79_RS15000	COG5002	protein histidine kinase activity
DOO79_RS15010	COG0477	Major facilitator Superfamily
DOO79_RS15035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DOO79_RS15055	COG4566	intracellular signal transduction
DOO79_RS15085	COG3685	Protein conserved in bacteria
DOO79_RS15120	COG1648	precorrin-2 dehydrogenase activity
DOO79_RS15120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DOO79_RS15130	COG0746	molybdenum cofactor guanylyltransferase activity
DOO79_RS15145	COG0708	Exodeoxyribonuclease III
DOO79_RS15180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DOO79_RS15190	COG0303	'Molybdopterin
DOO79_RS15195	COG1160	GTP binding
DOO79_RS15200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DOO79_RS15210	COG1426	Protein conserved in bacteria
DOO79_RS15220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DOO79_RS15235	COG1024	Enoyl-CoA hydratase
DOO79_RS15235	COG1250	3-hydroxyacyl-CoA dehydrogenase
DOO79_RS15240	COG0183	Belongs to the thiolase family
DOO79_RS15245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DOO79_RS15250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DOO79_RS15260	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DOO79_RS15270	COG1674	ftsk spoiiie
DOO79_RS15275	COG0492	ferredoxin-NADP+ reductase activity
DOO79_RS15295	COG0542	response to heat
DOO79_RS15310	COG0482	sulfurtransferase activity
DOO79_RS15315	COG2915	High frequency lysogenization protein hflD homolog
DOO79_RS15345	COG5002	protein histidine kinase activity
DOO79_RS15365	COG0784	Response regulator, receiver
DOO79_RS15365	COG0835	chemotaxis
DOO79_RS15375	COG1558	bacterial-type flagellum-dependent cell motility
DOO79_RS15380	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DOO79_RS15390	COG4787	bacterial-type flagellum-dependent cell motility
DOO79_RS15400	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DOO79_RS15405	COG1706	bacterial-type flagellum-dependent cell motility
DOO79_RS15410	COG1705	Flagellar rod assembly protein muramidase FlgJ
DOO79_RS15410	COG3951	Flagellar rod assembly protein muramidase FlgJ
DOO79_RS15420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOO79_RS15425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOO79_RS15435	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DOO79_RS15465	COG2201	protein-glutamate methylesterase activity
DOO79_RS15510	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS15515	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS15560	COG1677	Flagellar hook-basal body complex protein FliE
DOO79_RS15610	COG3190	flagellar
DOO79_RS15625	COG1684	flagellar biosynthetic protein fliR
DOO79_RS15650	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DOO79_RS15680	COG0643	Histidine kinase
DOO79_RS15680	COG0784	Response regulator, receiver
DOO79_RS15680	COG2198	Histidine kinase
DOO79_RS15690	COG0641	radical SAM
DOO79_RS15715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DOO79_RS15720	COG1360	Flagellar Motor Protein
DOO79_RS15740	COG0745	RESPONSE REGULATOR receiver
DOO79_RS15745	COG0643	Histidine kinase
DOO79_RS15745	COG2198	Histidine kinase
DOO79_RS15750	COG0840	transmembrane signaling receptor activity
DOO79_RS15765	COG0840	transmembrane signaling receptor activity
DOO79_RS15775	COG0840	transmembrane signaling receptor activity
DOO79_RS15780	COG0840	transmembrane signaling receptor activity
DOO79_RS15790	COG0840	transmembrane signaling receptor activity
DOO79_RS15795	COG0840	transmembrane signaling receptor activity
DOO79_RS15805	COG0840	transmembrane signaling receptor activity
DOO79_RS15810	COG0840	transmembrane signaling receptor activity
DOO79_RS15815	COG0840	transmembrane signaling receptor activity
DOO79_RS15820	COG0840	transmembrane signaling receptor activity
DOO79_RS15825	COG0840	transmembrane signaling receptor activity
DOO79_RS15835	COG0835	chemotaxis
DOO79_RS15845	COG0840	transmembrane signaling receptor activity
DOO79_RS15855	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DOO79_RS15860	COG2201	protein-glutamate methylesterase activity
DOO79_RS15870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DOO79_RS15900	COG0318	PFAM AMP-dependent synthetase and ligase
DOO79_RS15930	COG1024	Enoyl-CoA hydratase
DOO79_RS15935	COG2205	protein histidine kinase activity
DOO79_RS15935	COG2198	Histidine kinase
DOO79_RS15935	COG0784	Response regulator, receiver
DOO79_RS15945	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DOO79_RS15955	COG3279	Response regulator of the LytR AlgR family
DOO79_RS16010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DOO79_RS16020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DOO79_RS16025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DOO79_RS16035	COG0505	Belongs to the CarA family
DOO79_RS16040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DOO79_RS16045	COG2258	MOSC domain
DOO79_RS16095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DOO79_RS16115	COG0277	FAD linked oxidase domain protein
DOO79_RS16120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DOO79_RS16130	COG0531	amino acid
DOO79_RS16140	COG2188	Transcriptional regulator
DOO79_RS16205	COG0531	amino acid
DOO79_RS16210	COG0235	Class ii aldolase
DOO79_RS16215	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DOO79_RS16220	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DOO79_RS16235	COG0140	phosphoribosyl-ATP diphosphatase activity
DOO79_RS16235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DOO79_RS16240	COG0107	imidazoleglycerol-phosphate synthase activity
DOO79_RS16245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DOO79_RS16250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DOO79_RS16255	COG0131	Imidazoleglycerol-phosphate dehydratase
DOO79_RS16255	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DOO79_RS16260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DOO79_RS16265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DOO79_RS16270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DOO79_RS16280	COG0124	histidyl-tRNA synthetase
DOO79_RS16285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOO79_RS16380	COG0726	polysaccharide deacetylase
DOO79_RS16380	COG1649	PFAM Uncharacterised BCR, COG1649
DOO79_RS16515	COG0531	amino acid
DOO79_RS16530	COG0006	proline dipeptidase activity
DOO79_RS16540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DOO79_RS16555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DOO79_RS16560	COG3938	Belongs to the proline racemase family
DOO79_RS16570	COG0552	protein localization to endoplasmic reticulum
DOO79_RS16575	COG1194	a g-specific adenine glycosylase
DOO79_RS16580	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DOO79_RS16585	COG0784	Response regulator, receiver
DOO79_RS16585	COG4191	Histidine kinase
DOO79_RS16625	COG3040	lipid binding
DOO79_RS16640	COG1960	acyl-CoA dehydrogenase activity
DOO79_RS16650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DOO79_RS16670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOO79_RS16675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOO79_RS16680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DOO79_RS16705	COG0438	transferase activity, transferring glycosyl groups
DOO79_RS16715	COG0438	transferase activity, transferring glycosyl groups
DOO79_RS16720	COG0438	transferase activity, transferring glycosyl groups
DOO79_RS16775	COG0072	phenylalanine-tRNA ligase activity
DOO79_RS16775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOO79_RS16780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DOO79_RS16795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DOO79_RS16800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DOO79_RS16850	COG2948	multi-organism process
DOO79_RS16870	COG3505	Type IV secretory pathway VirD4
DOO79_RS16885	COG0556	nucleotide-excision repair
DOO79_RS16940	COG1611	Belongs to the LOG family
DOO79_RS16950	COG2095	MarC family integral membrane protein
DOO79_RS16960	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DOO79_RS16995	COG1185	polyribonucleotide nucleotidyltransferase activity
DOO79_RS17000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DOO79_RS17005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DOO79_RS17010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DOO79_RS17015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DOO79_RS17020	COG0195	Participates in both transcription termination and antitermination
DOO79_RS17025	COG0779	Required for maturation of 30S ribosomal subunits
DOO79_RS17035	COG1007	ATP synthesis coupled electron transport
DOO79_RS17055	COG0839	Belongs to the complex I subunit 6 family
DOO79_RS17060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOO79_RS17065	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DOO79_RS17075	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DOO79_RS17080	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DOO79_RS17085	COG0649	NAD binding
DOO79_RS17090	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOO79_RS17095	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOO79_RS17100	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOO79_RS17115	COG0149	triose-phosphate isomerase activity
DOO79_RS17120	COG0300	oxidoreductase activity
DOO79_RS17150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DOO79_RS17155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DOO79_RS17160	COG0159	tryptophan synthase activity
DOO79_RS17170	COG0133	tryptophan synthase activity
DOO79_RS17180	COG0135	phosphoribosylanthranilate isomerase activity
DOO79_RS17185	COG0101	tRNA pseudouridine synthase activity
DOO79_RS17205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DOO79_RS17210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DOO79_RS17215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DOO79_RS17220	COG2890	protein-(glutamine-N5) methyltransferase activity
DOO79_RS17230	COG0688	phosphatidylethanolamine metabolic process
DOO79_RS17240	COG0433	COG0433 Predicted ATPase
DOO79_RS17245	COG0494	nUDIX hydrolase
DOO79_RS17260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DOO79_RS17265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DOO79_RS17280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DOO79_RS17310	COG4695	Portal protein
DOO79_RS17355	COG3179	chitinase
DOO79_RS17555	COG0717	Belongs to the dCTP deaminase family
DOO79_RS17560	COG0489	protein tyrosine kinase activity
DOO79_RS17585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DOO79_RS17595	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DOO79_RS17615	COG0534	Mate efflux family protein
DOO79_RS17620	COG0335	large ribosomal subunit rRNA binding
DOO79_RS17625	COG0336	Belongs to the RNA methyltransferase TrmD family
DOO79_RS17630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DOO79_RS17635	COG0228	four-way junction DNA binding
DOO79_RS17640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DOO79_RS17650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DOO79_RS17655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DOO79_RS17700	COG2205	protein histidine kinase activity
DOO79_RS17700	COG3437	response regulator, receiver
DOO79_RS17700	COG3850	Histidine kinase
DOO79_RS17700	COG4999	Histidine kinase
DOO79_RS17705	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DOO79_RS17715	COG2205	protein histidine kinase activity
DOO79_RS17720	COG5507	3-demethylubiquinone-9 3-methyltransferase
DOO79_RS17730	COG4771	TonB-dependent receptor
DOO79_RS17755	COG2172	sigma factor antagonist activity
DOO79_RS17760	COG1366	Belongs to the anti-sigma-factor antagonist family
DOO79_RS17765	COG1366	Belongs to the anti-sigma-factor antagonist family
DOO79_RS17780	COG0326	Molecular chaperone. Has ATPase activity
DOO79_RS17785	COG2207	Transcriptional regulator
DOO79_RS17795	COG3152	Membrane
DOO79_RS17810	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DOO79_RS17815	COG1845	cytochrome c oxidase, subunit III
DOO79_RS17820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DOO79_RS17835	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DOO79_RS17840	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DOO79_RS17845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DOO79_RS17850	COG0196	riboflavin kinase activity
DOO79_RS17860	COG0268	Binds directly to 16S ribosomal RNA
DOO79_RS17865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DOO79_RS17870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DOO79_RS17875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DOO79_RS17880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DOO79_RS17885	COG0824	Thioesterase
DOO79_RS17930	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DOO79_RS17940	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DOO79_RS17965	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DOO79_RS17980	COG2197	response regulator
DOO79_RS17985	COG4585	Histidine kinase
DOO79_RS17995	COG0850	regulation of cytokinetic process
DOO79_RS18000	COG2894	cell division
DOO79_RS18005	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DOO79_RS18015	COG0642	Histidine kinase
DOO79_RS18020	COG0745	RESPONSE REGULATOR receiver
DOO79_RS18035	COG2194	sulfuric ester hydrolase activity
DOO79_RS18050	COG2814	Major facilitator Superfamily
DOO79_RS18055	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DOO79_RS18055	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DOO79_RS18065	COG0656	L-ascorbic acid biosynthetic process
DOO79_RS18070	COG0753	catalase activity
DOO79_RS18090	COG2207	Transcriptional regulator
DOO79_RS18090	COG1917	Cupin 2, conserved barrel domain protein
DOO79_RS18150	COG0492	ferredoxin-NADP+ reductase activity
DOO79_RS18160	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS18165	COG3537	Alpha-1,2-mannosidase
DOO79_RS18170	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS18175	COG3387	PFAM Glycoside hydrolase 15-related
DOO79_RS18185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DOO79_RS18215	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DOO79_RS18240	COG0732	type I restriction modification DNA specificity domain
DOO79_RS18270	COG1309	transcriptional regulator
DOO79_RS18275	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS18280	COG0308	aminopeptidase N
DOO79_RS18285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DOO79_RS18295	COG0330	HflC and HflK could
DOO79_RS18300	COG0330	HflC and HflK could
DOO79_RS18320	COG0678	peroxiredoxin activity
DOO79_RS18330	COG4953	penicillin-binding protein 1C
DOO79_RS18345	COG2373	Large extracellular alpha-helical protein
DOO79_RS18370	COG3609	addiction module antidote protein, CC2985 family
DOO79_RS18390	COG3829	transcription factor binding
DOO79_RS18415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DOO79_RS18420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DOO79_RS18435	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS18450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DOO79_RS18455	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DOO79_RS18460	COG1399	metal-binding, possibly nucleic acid-binding protein
DOO79_RS18465	COG0424	maF-like protein
DOO79_RS18495	COG0714	Associated with various cellular activities
DOO79_RS18515	COG0537	adenosine 5'-monophosphoramidase activity
DOO79_RS18520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DOO79_RS18525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DOO79_RS18545	COG0314	molybdopterin synthase activity
DOO79_RS18550	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DOO79_RS18555	COG0315	cyclic pyranopterin monophosphate synthase activity
DOO79_RS18560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DOO79_RS18565	COG1234	tRNA 3'-trailer cleavage
DOO79_RS18570	COG3642	lipopolysaccharide core region biosynthetic process
DOO79_RS18575	COG0859	PFAM glycosyl transferase family 9
DOO79_RS18590	COG0631	protein serine/threonine phosphatase activity
DOO79_RS18595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DOO79_RS18600	COG0328	RNA-DNA hybrid ribonuclease activity
DOO79_RS18610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOO79_RS18620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOO79_RS18645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DOO79_RS18655	COG0544	peptidyl-prolyl cis-trans isomerase activity
DOO79_RS18665	COG3852	Histidine kinase
DOO79_RS18695	COG0473	3-isopropylmalate dehydrogenase activity
DOO79_RS18710	COG4783	chaperone-mediated protein folding
DOO79_RS18725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DOO79_RS18735	COG0438	transferase activity, transferring glycosyl groups
DOO79_RS18740	COG0671	phosphoesterase, PA-phosphatase related
DOO79_RS18745	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DOO79_RS18760	COG2833	Protein of unknown function (DUF455)
DOO79_RS18780	COG0285	dihydrofolate synthase activity
DOO79_RS18795	COG0406	alpha-ribazole phosphatase activity
DOO79_RS18825	COG1063	alcohol dehydrogenase
DOO79_RS18835	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DOO79_RS18840	COG4208	sulfate ABC transporter
DOO79_RS18845	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DOO79_RS18850	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DOO79_RS18855	COG0156	8-amino-7-oxononanoate synthase activity
DOO79_RS18885	COG1902	pentaerythritol trinitrate reductase activity
DOO79_RS18885	COG0446	pyridine nucleotide-disulphide oxidoreductase
DOO79_RS18895	COG0625	glutathione transferase activity
DOO79_RS18905	COG0039	L-malate dehydrogenase activity
DOO79_RS18910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DOO79_RS18915	COG1217	gtp-binding protein TYPA
DOO79_RS18925	COG0154	amidase activity
DOO79_RS18935	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DOO79_RS18950	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DOO79_RS18955	COG0203	ribosomal protein L17
DOO79_RS18980	COG0201	protein transport
DOO79_RS18985	COG0200	Binds to the 23S rRNA
DOO79_RS18990	COG1841	ribosomal large subunit assembly
DOO79_RS19000	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DOO79_RS19005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DOO79_RS19010	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DOO79_RS19020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DOO79_RS19025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DOO79_RS19035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DOO79_RS19040	COG0255	Belongs to the universal ribosomal protein uL29 family
DOO79_RS19045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DOO79_RS19050	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DOO79_RS19060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DOO79_RS19065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DOO79_RS19070	COG0089	rRNA binding
DOO79_RS19075	COG0088	Forms part of the polypeptide exit tunnel
DOO79_RS19080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DOO79_RS19085	COG0051	transcription antitermination factor activity, RNA binding
DOO79_RS19090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DOO79_RS19095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DOO79_RS19100	COG0049	tRNA binding
DOO79_RS19105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DOO79_RS19110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DOO79_RS19115	COG0085	RNA polymerase activity
DOO79_RS19120	COG0222	ribosome binding
DOO79_RS19125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DOO79_RS19130	COG0081	regulation of translation
DOO79_RS19135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DOO79_RS19140	COG0250	Participates in transcription elongation, termination and antitermination
DOO79_RS19155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DOO79_RS19175	COG0012	GTP binding
DOO79_RS19180	COG0193	aminoacyl-tRNA hydrolase activity
DOO79_RS19185	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DOO79_RS19190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DOO79_RS19200	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DOO79_RS19205	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DOO79_RS19215	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DOO79_RS19220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DOO79_RS19250	COG1254	Belongs to the acylphosphatase family
DOO79_RS19260	COG1295	ribonuclease BN
DOO79_RS19285	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DOO79_RS19290	COG1404	Belongs to the peptidase S8 family
DOO79_RS19295	COG1404	Belongs to the peptidase S8 family
DOO79_RS19300	COG1404	Belongs to the peptidase S8 family
DOO79_RS19305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DOO79_RS19325	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DOO79_RS19345	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DOO79_RS19375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOO79_RS19375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOO79_RS19395	COG2890	protein-(glutamine-N5) methyltransferase activity
DOO79_RS19405	COG3634	alkyl hydroperoxide reductase activity
DOO79_RS19410	COG0583	DNA-binding transcription factor activity
DOO79_RS19415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DOO79_RS19420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DOO79_RS19430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOO79_RS19465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DOO79_RS19470	COG0697	spore germination
DOO79_RS19495	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DOO79_RS19510	COG3386	PFAM SMP-30 Gluconolaconase
DOO79_RS19530	COG1024	Enoyl-CoA hydratase
DOO79_RS19540	COG0318	PFAM AMP-dependent synthetase and ligase
DOO79_RS19545	COG0583	DNA-binding transcription factor activity
DOO79_RS19550	COG3384	dioxygenase
DOO79_RS19580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DOO79_RS19585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DOO79_RS19595	COG2096	Adenosyltransferase
DOO79_RS19600	COG0123	including yeast histone deacetylase and acetoin utilization protein
DOO79_RS19605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DOO79_RS19610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOO79_RS19615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DOO79_RS19620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DOO79_RS19625	COG2967	ApaG domain
DOO79_RS19630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DOO79_RS19640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DOO79_RS19650	COG0747	negative chemotaxis
DOO79_RS19675	COG0431	NADPH-dependent FMN reductase
DOO79_RS19680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DOO79_RS19690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOO79_RS19695	COG1116	anion transmembrane transporter activity
DOO79_RS19705	COG3829	transcription factor binding
DOO79_RS19720	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DOO79_RS19725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DOO79_RS19760	COG0588	phosphoglycerate mutase activity
DOO79_RS19765	COG1515	deoxyribonuclease V activity
DOO79_RS19775	COG1741	Belongs to the pirin family
DOO79_RS19790	COG1741	Belongs to the pirin family
DOO79_RS19795	COG1966	Carbon starvation protein
DOO79_RS19800	COG2879	small protein
DOO79_RS19835	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DOO79_RS19840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DOO79_RS19845	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DOO79_RS19850	COG2080	2 iron, 2 sulfur cluster binding
DOO79_RS19855	COG1028	Short-chain dehydrogenase reductase Sdr
DOO79_RS19855	COG0604	alcohol dehydrogenase
DOO79_RS19855	COG3321	synthase
DOO79_RS19860	COG4251	negative regulation of phosphorylation
DOO79_RS19860	COG5001	Diguanylate cyclase
DOO79_RS19860	COG3706	GGDEF domain
DOO79_RS19860	COG2203	Gaf domain
DOO79_RS19865	COG0629	single-stranded DNA binding
DOO79_RS19870	COG0142	geranyltranstransferase activity
DOO79_RS19885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DOO79_RS19900	COG0527	aspartate kinase activity
DOO79_RS19905	COG0384	phenazine biosynthesis protein PhzF
DOO79_RS19920	COG1764	response to oxidative stress
DOO79_RS19925	COG0540	Belongs to the ATCase OTCase family
DOO79_RS19930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DOO79_RS19935	COG1678	Uncharacterized ACR, COG1678
DOO79_RS19940	COG0519	Catalyzes the synthesis of GMP from XMP
DOO79_RS19955	COG5297	Belongs to the glycosyl hydrolase family 6
DOO79_RS19970	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DOO79_RS19985	COG0739	heme binding
DOO79_RS20005	COG0693	protein deglycase activity
DOO79_RS20015	COG1959	2 iron, 2 sulfur cluster binding
DOO79_RS20020	COG0719	Fe-S assembly protein
DOO79_RS20025	COG0396	ATPase activity
DOO79_RS20030	COG0719	Fe-S assembly protein
DOO79_RS20035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DOO79_RS20045	COG2146	nitrite reductase [NAD(P)H] activity
DOO79_RS20050	COG4774	siderophore transport
DOO79_RS20055	COG3128	pkhd-type hydroxylase
DOO79_RS20080	COG1477	protein flavinylation
DOO79_RS20085	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DOO79_RS20100	COG1555	photosystem II stabilization
DOO79_RS20115	COG3178	'Phosphotransferase
DOO79_RS20120	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DOO79_RS20130	COG0628	permease
DOO79_RS20140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DOO79_RS20150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DOO79_RS20170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DOO79_RS20175	COG0271	Belongs to the BolA IbaG family
DOO79_RS20185	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DOO79_RS20195	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DOO79_RS20200	COG1137	ATPase activity
DOO79_RS20215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOO79_RS20220	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DOO79_RS20225	COG1660	Displays ATPase and GTPase activities
DOO79_RS20235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOO79_RS20240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DOO79_RS20245	COG2239	Acts as a magnesium transporter
DOO79_RS20260	COG1294	oxidase, subunit
DOO79_RS20265	COG1271	oxidase subunit
DOO79_RS20285	COG1113	amino acid transport
DOO79_RS20305	COG2197	response regulator
DOO79_RS20310	COG0531	amino acid
DOO79_RS20330	COG1234	tRNA 3'-trailer cleavage
DOO79_RS20385	COG2814	Major facilitator Superfamily
DOO79_RS20395	COG0754	glutathionylspermidine amidase activity
DOO79_RS20420	COG1842	Phage shock protein A
DOO79_RS20430	COG0259	pyridoxamine-phosphate oxidase activity
DOO79_RS20435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DOO79_RS20440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DOO79_RS20450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DOO79_RS20455	COG0477	Major facilitator Superfamily
DOO79_RS20475	COG2198	Histidine kinase
DOO79_RS20475	COG0784	Response regulator, receiver
DOO79_RS20475	COG2205	protein histidine kinase activity
DOO79_RS20480	COG2353	YceI-like domain
DOO79_RS20500	COG1760	l-serine dehydratase
DOO79_RS20510	COG0527	aspartate kinase activity
DOO79_RS20510	COG0460	homoserine dehydrogenase
DOO79_RS20515	COG0626	cystathionine gamma-synthase activity
DOO79_RS20520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DOO79_RS20525	COG0739	heme binding
DOO79_RS20530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DOO79_RS20535	COG1272	protein, Hemolysin III
DOO79_RS20540	COG2982	Protein involved in outer membrane biogenesis
DOO79_RS20545	COG0517	IMP dehydrogenase activity
DOO79_RS20545	COG0516	GMP reductase activity
DOO79_RS20550	COG0463	Glycosyl transferase, family 2
DOO79_RS20555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOO79_RS20560	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DOO79_RS20570	COG4771	TonB-dependent receptor
DOO79_RS20585	COG1309	transcriptional regulator
DOO79_RS20595	COG1960	acyl-CoA dehydrogenase activity
DOO79_RS20630	COG0509	glycine decarboxylation via glycine cleavage system
DOO79_RS20635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DOO79_RS20650	COG1742	UPF0060 membrane protein
DOO79_RS20655	COG3956	TIGRFAM MazG family protein
DOO79_RS20665	COG0494	nUDIX hydrolase
DOO79_RS20675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DOO79_RS20680	COG0837	glucose binding
DOO79_RS20695	COG3858	chitin binding
DOO79_RS20695	COG1388	LysM domain
DOO79_RS20700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DOO79_RS20710	COG1472	Belongs to the glycosyl hydrolase 3 family
DOO79_RS20745	COG3537	Alpha-1,2-mannosidase
DOO79_RS20780	COG3142	Participates in the control of copper homeostasis
DOO79_RS20785	COG1446	asparaginase
DOO79_RS20805	COG2198	Histidine kinase
DOO79_RS20805	COG0643	Histidine kinase
DOO79_RS20805	COG0784	Response regulator, receiver
DOO79_RS20810	COG0840	transmembrane signaling receptor activity
DOO79_RS20815	COG0835	chemotaxis
DOO79_RS20830	COG0189	ligase activity
DOO79_RS20840	COG1397	ADP-ribosylglycohydrolase
DOO79_RS20850	COG1199	ATP-dependent helicase activity
DOO79_RS20860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOO79_RS20865	COG1215	transferase activity, transferring glycosyl groups
DOO79_RS20875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DOO79_RS20885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DOO79_RS20890	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DOO79_RS20895	COG0535	radical SAM domain protein
DOO79_RS20900	COG0535	radical SAM domain protein
DOO79_RS20925	COG1643	Atp-dependent helicase
DOO79_RS20930	COG0783	Belongs to the Dps family
DOO79_RS20935	COG0514	ATP-dependent DNA helicase (RecQ)
DOO79_RS20965	COG0840	transmembrane signaling receptor activity
DOO79_RS20985	COG3920	Histidine kinase
DOO79_RS20990	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DOO79_RS21000	COG0602	queuosine metabolic process
DOO79_RS21010	COG2885	chlorophyll binding
DOO79_RS21015	COG0823	Involved in the tonB-independent uptake of proteins
DOO79_RS21025	COG0848	biopolymer transport protein
DOO79_RS21035	COG0824	Thioesterase
DOO79_RS21040	COG2255	four-way junction helicase activity
DOO79_RS21050	COG3158	transport of potassium into the cell
DOO79_RS21055	COG0632	four-way junction helicase activity
DOO79_RS21060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DOO79_RS21065	COG0217	transcriptional regulatory protein
DOO79_RS21080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DOO79_RS21095	COG0477	Major facilitator Superfamily
DOO79_RS21135	COG0488	(ABC) transporter
DOO79_RS21165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DOO79_RS21165	COG4651	solute:proton antiporter activity
DOO79_RS21190	COG4772	TonB-dependent receptor
DOO79_RS21200	COG4264	IucA IucC family
DOO79_RS21215	COG0019	diaminopimelate decarboxylase activity
DOO79_RS21245	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DOO79_RS21255	COG1492	cobalamin metabolic process
DOO79_RS21285	COG4206	TonB-dependent receptor
DOO79_RS21290	COG0542	response to heat
DOO79_RS21295	COG1116	anion transmembrane transporter activity
DOO79_RS21300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOO79_RS21305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DOO79_RS21310	COG0667	Aldo Keto reductase
DOO79_RS21315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DOO79_RS21320	COG4771	TonB-dependent receptor
DOO79_RS21330	COG2827	Endonuclease containing a URI domain
DOO79_RS21370	COG1877	trehalose-phosphatase activity
DOO79_RS21375	COG3387	PFAM Glycoside hydrolase 15-related
DOO79_RS21390	COG0840	transmembrane signaling receptor activity
DOO79_RS21395	COG3011	Protein conserved in bacteria
DOO79_RS21410	COG0564	pseudouridine synthase activity
DOO79_RS21415	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DOO79_RS21425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DOO79_RS21425	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DOO79_RS21435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DOO79_RS21440	COG0045	succinate-CoA ligase (ADP-forming) activity
DOO79_RS21475	COG1459	type II secretion system
DOO79_RS21480	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DOO79_RS21485	COG0237	dephospho-CoA kinase activity
DOO79_RS21505	COG0436	Aminotransferase
DOO79_RS21525	COG0726	polysaccharide deacetylase
DOO79_RS21530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DOO79_RS21545	COG3964	amidohydrolase
DOO79_RS21550	COG0402	S-adenosylhomocysteine deaminase activity
DOO79_RS21580	COG1307	EDD domain protein, DegV family
DOO79_RS21585	COG0242	peptide deformylase activity
DOO79_RS21605	COG0457	Tetratricopeptide repeat
DOO79_RS21610	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DOO79_RS21615	COG1215	transferase activity, transferring glycosyl groups
DOO79_RS21620	COG1215	transferase activity, transferring glycosyl groups
DOO79_RS21635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DOO79_RS21690	COG2188	Transcriptional regulator
DOO79_RS21705	COG1450	Type ii and iii secretion system protein
DOO79_RS21720	COG3166	PFAM Fimbrial assembly family protein
DOO79_RS21725	COG3156	type II secretion system protein K
DOO79_RS21730	COG4795	General secretion pathway protein
DOO79_RS21735	COG2165	general secretion pathway protein
DOO79_RS21740	COG4970	Tfp pilus assembly protein FimT
DOO79_RS21745	COG2165	general secretion pathway protein
DOO79_RS21750	COG1459	type II secretion system
DOO79_RS21755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DOO79_RS21760	COG1404	Belongs to the peptidase S8 family
DOO79_RS21765	COG5295	Hep Hag repeat protein
DOO79_RS21770	COG1404	Belongs to the peptidase S8 family
DOO79_RS21775	COG5295	Hep Hag repeat protein
DOO79_RS21780	COG0047	phosphoribosylformylglycinamidine synthase activity
DOO79_RS21780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DOO79_RS21785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DOO79_RS21790	COG4974	Belongs to the 'phage' integrase family
DOO79_RS21805	COG0795	lipopolysaccharide-transporting ATPase activity
DOO79_RS21815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DOO79_RS21830	COG0525	valine-tRNA ligase activity
DOO79_RS21850	COG0741	lytic transglycosylase activity
DOO79_RS21875	COG1183	phosphatidylcholine synthase activity
DOO79_RS21885	COG0442	prolyl-tRNA aminoacylation
DOO79_RS21900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DOO79_RS21905	COG1127	ABC transporter
DOO79_RS21910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DOO79_RS21910	COG3218	ABC-type transport auxiliary lipoprotein component
DOO79_RS21945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DOO79_RS21950	COG0662	Cupin 2, conserved barrel domain protein
DOO79_RS21950	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DOO79_RS21980	COG2086	electron transfer activity
DOO79_RS21995	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DOO79_RS21995	COG0546	phosphoglycolate phosphatase activity
DOO79_RS22000	COG0277	FAD linked oxidase domain protein
DOO79_RS22015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOO79_RS22130	COG4691	Plasmid stability protein
DOO79_RS22145	COG3318	Belongs to the UPF0149 family
DOO79_RS22145	COG3012	SEC-C Motif Domain Protein
DOO79_RS22200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DOO79_RS22215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOO79_RS22305	COG1192	Involved in chromosome partitioning
DOO79_RS22420	COG3318	Belongs to the UPF0149 family
DOO79_RS22420	COG3012	SEC-C Motif Domain Protein
DOO79_RS22590	COG3704	protein secretion by the type IV secretion system
DOO79_RS22600	COG3504	Conjugal transfer protein
DOO79_RS22605	COG2948	multi-organism process
DOO79_RS22735	COG1192	Involved in chromosome partitioning
DOO79_RS22800	COG4691	Plasmid stability protein
DOO79_RS22805	COG1487	ribonuclease activity
DOO79_RS22815	COG3012	SEC-C Motif Domain Protein
DOO79_RS22815	COG3318	Belongs to the UPF0149 family