locus-tag	class	description
AMD06_RS00030	COG0187	DNA topoisomerase II activity
AMD06_RS00095	COG0592	DNA-directed DNA polymerase activity
AMD06_RS00360	COG3250	beta-galactosidase activity
AMD06_RS00370	COG3693	PFAM glycoside hydrolase, family 10
AMD06_RS00370	COG2382	esterase
AMD06_RS00400	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AMD06_RS00410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMD06_RS00415	COG0187	DNA topoisomerase II activity
AMD06_RS00425	COG0501	Belongs to the peptidase M48B family
AMD06_RS00455	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMD06_RS00465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD06_RS00510	COG0793	Belongs to the peptidase S41A family
AMD06_RS00515	COG4942	peptidase
AMD06_RS00525	COG2234	aminopeptidase activity
AMD06_RS00535	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD06_RS00540	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD06_RS00575	COG2211	Major facilitator Superfamily
AMD06_RS00590	COG3693	PFAM glycoside hydrolase, family 10
AMD06_RS00605	COG3693	PFAM glycoside hydrolase, family 10
AMD06_RS00610	COG1904	glucuronate isomerase
AMD06_RS00615	COG3250	beta-galactosidase activity
AMD06_RS00625	COG3386	PFAM SMP-30 Gluconolaconase
AMD06_RS00650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMD06_RS00690	COG0246	Mannitol dehydrogenase
AMD06_RS00695	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD06_RS00705	COG4948	Mandelate Racemase Muconate Lactonizing
AMD06_RS00715	COG3661	Belongs to the glycosyl hydrolase 67 family
AMD06_RS00725	COG2115	Belongs to the xylose isomerase family
AMD06_RS00735	COG2974	May be involved in recombination
AMD06_RS00755	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AMD06_RS00765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMD06_RS00770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMD06_RS00775	COG0805	protein transport
AMD06_RS00785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD06_RS00785	COG0519	Catalyzes the synthesis of GMP from XMP
AMD06_RS00795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD06_RS00800	COG0752	glycyl-tRNA synthetase alpha subunit
AMD06_RS00830	COG0729	surface antigen
AMD06_RS00835	COG2911	Protein conserved in bacteria
AMD06_RS00855	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD06_RS00860	COG3265	gluconokinase activity
AMD06_RS00865	COG2211	Major facilitator Superfamily
AMD06_RS00870	COG3459	Glycosyltransferase 36 associated
AMD06_RS00885	COG2205	protein histidine kinase activity
AMD06_RS00890	COG1971	Probably functions as a manganese efflux pump
AMD06_RS00895	COG1414	Transcriptional regulator
AMD06_RS00900	COG0738	Major facilitator superfamily
AMD06_RS00905	COG3254	rhamnose metabolic process
AMD06_RS00915	COG4948	Mandelate Racemase Muconate Lactonizing
AMD06_RS00920	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMD06_RS00925	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS00945	COG3507	Belongs to the glycosyl hydrolase 43 family
AMD06_RS00975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMD06_RS00985	COG3162	membrane
AMD06_RS00990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMD06_RS01000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD06_RS01010	COG1846	Transcriptional regulator
AMD06_RS01010	COG1940	carbohydrate kinase activity
AMD06_RS01015	COG0708	Exodeoxyribonuclease III
AMD06_RS01035	COG2091	lysine biosynthetic process via aminoadipic acid
AMD06_RS01045	COG3540	Alkaline phosphatase
AMD06_RS01050	COG0357	Ribosomal RNA small subunit methyltransferase G
AMD06_RS01070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD06_RS01090	COG2159	amidohydrolase
AMD06_RS01100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMD06_RS01105	COG0583	DNA-binding transcription factor activity
AMD06_RS01110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD06_RS01125	COG0210	DNA helicase
AMD06_RS01285	COG0631	protein serine/threonine phosphatase activity
AMD06_RS01290	COG0515	serine threonine protein kinase
AMD06_RS01290	COG2815	serine threonine protein kinase
AMD06_RS01325	COG0408	coproporphyrinogen oxidase activity
AMD06_RS01340	COG4946	Tricorn protease homolog
AMD06_RS01340	COG1506	peptidase
AMD06_RS01340	COG0823	Involved in the tonB-independent uptake of proteins
AMD06_RS01365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMD06_RS01380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD06_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS01430	COG0463	Glycosyl transferase, family 2
AMD06_RS01440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMD06_RS01445	COG3100	YcgL domain-containing protein
AMD06_RS01460	COG3387	PFAM Glycoside hydrolase 15-related
AMD06_RS01465	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AMD06_RS01475	COG3338	carbonate dehydratase activity
AMD06_RS01480	COG2239	Acts as a magnesium transporter
AMD06_RS01485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMD06_RS01485	COG0045	succinate-CoA ligase (ADP-forming) activity
AMD06_RS01485	COG1042	CoA-binding domain protein
AMD06_RS01495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD06_RS01500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD06_RS01530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMD06_RS01540	COG0842	Transport permease protein
AMD06_RS01545	COG1131	(ABC) transporter
AMD06_RS01550	COG0543	2 iron, 2 sulfur cluster binding
AMD06_RS01550	COG0633	Ferredoxin
AMD06_RS01595	COG1476	TRANSCRIPTIONal
AMD06_RS01605	COG4555	ABC transporter
AMD06_RS01645	COG0625	glutathione transferase activity
AMD06_RS01705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMD06_RS01720	COG1199	ATP-dependent helicase activity
AMD06_RS01740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMD06_RS01785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMD06_RS01800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMD06_RS01840	COG3237	CsbD-like
AMD06_RS01845	COG0180	Tryptophanyl-tRNA synthetase
AMD06_RS01850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD06_RS01865	COG0697	spore germination
AMD06_RS01890	COG1136	(ABC) transporter
AMD06_RS01895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD06_RS01900	COG4585	Histidine kinase
AMD06_RS01905	COG2197	response regulator
AMD06_RS01920	COG0753	catalase activity
AMD06_RS01935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMD06_RS01940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMD06_RS01965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD06_RS01985	COG0642	Histidine kinase
AMD06_RS01995	COG1090	epimerase
AMD06_RS02035	COG1690	Belongs to the RtcB family
AMD06_RS02070	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AMD06_RS02085	COG0606	chelatase, subunit chli
AMD06_RS02125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AMD06_RS02130	COG1166	arginine decarboxylase activity
AMD06_RS02140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD06_RS02150	COG2755	lipolytic protein G-D-S-L family
AMD06_RS02150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMD06_RS02155	COG4221	oxidoreductase activity
AMD06_RS02170	COG0018	arginyl-trna synthetase
AMD06_RS02175	COG2003	Belongs to the UPF0758 family
AMD06_RS02180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMD06_RS02185	COG0756	dUTP diphosphatase activity
AMD06_RS02205	COG0463	Glycosyl transferase, family 2
AMD06_RS02220	COG1475	DNA binding
AMD06_RS02225	COG1192	Involved in chromosome partitioning
AMD06_RS02235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMD06_RS02240	COG0708	Exodeoxyribonuclease III
AMD06_RS02245	COG2223	nitrite transmembrane transporter activity
AMD06_RS02255	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AMD06_RS02260	COG0739	heme binding
AMD06_RS02265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMD06_RS02295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMD06_RS02305	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AMD06_RS02315	COG1435	thymidine kinase activity
AMD06_RS02320	COG0210	DNA helicase
AMD06_RS02340	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AMD06_RS02345	COG0284	orotidine-5'-phosphate decarboxylase activity
AMD06_RS02380	COG2937	Belongs to the GPAT DAPAT family
AMD06_RS02410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD06_RS02415	COG1064	alcohol dehydrogenase
AMD06_RS02420	COG0493	'glutamate synthase
AMD06_RS02425	COG0070	glutamate synthase
AMD06_RS02425	COG0067	glutamate synthase
AMD06_RS02425	COG0069	glutamate synthase activity
AMD06_RS02485	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AMD06_RS02490	COG0438	transferase activity, transferring glycosyl groups
AMD06_RS02490	COG0297	glycogen (starch) synthase activity
AMD06_RS02540	COG1132	(ABC) transporter
AMD06_RS02570	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AMD06_RS02655	COG1205	dead DEAH box helicase
AMD06_RS02655	COG1111	helicase
AMD06_RS02660	COG1272	protein, Hemolysin III
AMD06_RS02675	COG0300	oxidoreductase activity
AMD06_RS02680	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS02700	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMD06_RS02705	COG2963	transposase activity
AMD06_RS02760	COG3237	CsbD-like
AMD06_RS02810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD06_RS02820	COG0477	Major facilitator Superfamily
AMD06_RS02860	COG0714	Associated with various cellular activities
AMD06_RS02890	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AMD06_RS02900	COG4772	TonB-dependent receptor
AMD06_RS02910	COG0662	Cupin 2, conserved barrel domain protein
AMD06_RS02915	COG1012	belongs to the aldehyde dehydrogenase family
AMD06_RS02940	COG1304	FMN binding
AMD06_RS02955	COG4585	Histidine kinase
AMD06_RS02960	COG2197	response regulator
AMD06_RS02980	COG3710	Transcriptional regulator
AMD06_RS02985	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMD06_RS03050	COG2963	transposase activity
AMD06_RS03055	COG2801	Transposase and inactivated derivatives
AMD06_RS03060	COG0366	Alpha amylase catalytic
AMD06_RS03065	COG0366	Alpha amylase catalytic
AMD06_RS03070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMD06_RS03090	COG2755	lipolytic protein G-D-S-L family
AMD06_RS03090	COG0657	acetylesterase activity
AMD06_RS03100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMD06_RS03115	COG3507	Belongs to the glycosyl hydrolase 43 family
AMD06_RS03120	COG1609	Transcriptional regulator
AMD06_RS03125	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AMD06_RS03130	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS03140	COG2755	lipolytic protein G-D-S-L family
AMD06_RS03155	COG3186	Phenylalanine-4-hydroxylase
AMD06_RS03160	COG1522	sequence-specific DNA binding
AMD06_RS03170	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMD06_RS03180	COG1119	ATPase activity
AMD06_RS03195	COG1125	glycine betaine transport
AMD06_RS03210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMD06_RS03230	COG1396	sequence-specific DNA binding
AMD06_RS03255	COG0489	protein tyrosine kinase activity
AMD06_RS03260	COG2062	phosphohistidine phosphatase, SixA
AMD06_RS03270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD06_RS03315	COG1968	undecaprenyl-diphosphatase activity
AMD06_RS03320	COG0174	glutamine synthetase
AMD06_RS03325	COG0347	Belongs to the P(II) protein family
AMD06_RS03330	COG0004	ammonium transporteR
AMD06_RS03335	COG3852	Histidine kinase
AMD06_RS03340	COG2204	response regulator
AMD06_RS03345	COG2032	superoxide dismutase activity
AMD06_RS03350	COG2032	superoxide dismutase activity
AMD06_RS03365	COG0183	Belongs to the thiolase family
AMD06_RS03400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AMD06_RS03405	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AMD06_RS03410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMD06_RS03420	COG0028	Belongs to the TPP enzyme family
AMD06_RS03425	COG2205	protein histidine kinase activity
AMD06_RS03450	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AMD06_RS03465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD06_RS03475	COG0596	Alpha beta hydrolase
AMD06_RS03480	COG0727	PFAM Uncharacterised protein family (UPF0153)
AMD06_RS03485	COG0318	PFAM AMP-dependent synthetase and ligase
AMD06_RS03490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD06_RS03505	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMD06_RS03515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMD06_RS03525	COG0564	pseudouridine synthase activity
AMD06_RS03550	COG0339	signal peptide processing
AMD06_RS03580	COG0475	glutathione-regulated potassium exporter activity
AMD06_RS03585	COG0583	DNA-binding transcription factor activity
AMD06_RS03590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AMD06_RS03625	COG4770	biotin carboxylase activity
AMD06_RS03630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMD06_RS03635	COG1960	acyl-CoA dehydrogenase activity
AMD06_RS03690	COG0523	cobalamin synthesis protein
AMD06_RS03705	COG0697	spore germination
AMD06_RS03715	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AMD06_RS03720	COG1846	Transcriptional regulator
AMD06_RS03725	COG1764	response to oxidative stress
AMD06_RS03755	COG2130	NADP-dependent
AMD06_RS03770	COG1187	pseudouridine synthase activity
AMD06_RS03785	COG1643	Atp-dependent helicase
AMD06_RS03795	COG4807	Protein conserved in bacteria
AMD06_RS03800	COG2351	hydroxyisourate hydrolase activity
AMD06_RS03805	COG2072	flavoprotein involved in K transport
AMD06_RS03825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AMD06_RS03860	COG1957	nucleoside hydrolase
AMD06_RS03870	COG2252	PERMEase
AMD06_RS03895	COG0084	hydrolase, TatD family'
AMD06_RS03910	COG0583	DNA-binding transcription factor activity
AMD06_RS03915	COG2814	Major facilitator Superfamily
AMD06_RS03925	COG2267	carboxylic ester hydrolase activity
AMD06_RS03930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMD06_RS03935	COG1902	pentaerythritol trinitrate reductase activity
AMD06_RS03955	COG0745	RESPONSE REGULATOR receiver
AMD06_RS03960	COG2205	protein histidine kinase activity
AMD06_RS03965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD06_RS03985	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMD06_RS03990	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMD06_RS03995	COG0583	DNA-binding transcription factor activity
AMD06_RS04025	COG0702	epimerase
AMD06_RS04030	COG1733	regulation of RNA biosynthetic process
AMD06_RS04055	COG2801	Transposase and inactivated derivatives
AMD06_RS04060	COG2963	transposase activity
AMD06_RS04070	COG0129	dihydroxy-acid dehydratase activity
AMD06_RS04090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AMD06_RS04145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMD06_RS04150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AMD06_RS04175	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMD06_RS04180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMD06_RS04190	COG3485	protocatechuate 3,4-dioxygenase
AMD06_RS04195	COG3485	protocatechuate 3,4-dioxygenase
AMD06_RS04205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD06_RS04210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMD06_RS04220	COG1414	Transcriptional regulator
AMD06_RS04230	COG0657	acetylesterase activity
AMD06_RS04240	COG0445	tRNA wobble uridine modification
AMD06_RS04250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMD06_RS04280	COG2267	carboxylic ester hydrolase activity
AMD06_RS04290	COG0156	8-amino-7-oxononanoate synthase activity
AMD06_RS04295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AMD06_RS04300	COG1040	competence protein
AMD06_RS04305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMD06_RS04380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AMD06_RS04450	COG3264	Mechanosensitive ion channel
AMD06_RS04450	COG1511	domain protein
AMD06_RS04455	COG1368	sulfuric ester hydrolase activity
AMD06_RS04465	COG2354	Protein conserved in bacteria
AMD06_RS04475	COG0297	glycogen (starch) synthase activity
AMD06_RS04480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMD06_RS04485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMD06_RS04510	COG0702	epimerase
AMD06_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS04550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD06_RS04555	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS04565	COG0513	Belongs to the DEAD box helicase family
AMD06_RS04585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMD06_RS04595	COG3483	tryptophan 2,3-dioxygenase activity
AMD06_RS04600	COG3104	oligopeptide transport
AMD06_RS04620	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AMD06_RS04635	COG1320	monovalent cation:proton antiporter activity
AMD06_RS04640	COG2212	antiporter activity
AMD06_RS04650	COG0651	ATP synthesis coupled electron transport
AMD06_RS04655	COG1006	Multisubunit Na H antiporter MnhC subunit
AMD06_RS04660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMD06_RS04660	COG2111	Na H antiporter
AMD06_RS04680	COG3179	chitinase
AMD06_RS04700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMD06_RS04705	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AMD06_RS04720	COG0456	acetyltransferase
AMD06_RS04725	COG1597	lipid kinase activity
AMD06_RS04750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMD06_RS04755	COG0134	indole-3-glycerol-phosphate synthase activity
AMD06_RS04765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD06_RS04770	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMD06_RS04780	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AMD06_RS04790	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMD06_RS04805	COG1051	belongs to the nudix hydrolase family
AMD06_RS04845	COG0316	Belongs to the HesB IscA family
AMD06_RS04865	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMD06_RS04885	COG2814	Major facilitator Superfamily
AMD06_RS04890	COG0583	DNA-binding transcription factor activity
AMD06_RS04895	COG2814	Major facilitator Superfamily
AMD06_RS04900	COG1289	transmembrane transporter activity
AMD06_RS04910	COG0151	Belongs to the GarS family
AMD06_RS04920	COG0138	bifunctional purine biosynthesis protein purh
AMD06_RS04925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD06_RS04930	COG2267	carboxylic ester hydrolase activity
AMD06_RS04935	COG2453	phosphatase
AMD06_RS04935	COG0671	phosphoesterase, PA-phosphatase related
AMD06_RS04960	COG4589	Belongs to the CDS family
AMD06_RS04965	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AMD06_RS04990	COG2264	protein methyltransferase activity
AMD06_RS05010	COG0439	Biotin carboxylase
AMD06_RS05020	COG0511	ligase activity, forming carbon-carbon bonds
AMD06_RS05025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMD06_RS05035	COG1324	tolerance protein
AMD06_RS05060	COG0300	oxidoreductase activity
AMD06_RS05065	COG2356	endonuclease I
AMD06_RS05075	COG0459	protein refolding
AMD06_RS05090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AMD06_RS05105	COG3386	PFAM SMP-30 Gluconolaconase
AMD06_RS05115	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMD06_RS05120	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AMD06_RS05140	COG0778	Nitroreductase
AMD06_RS05145	COG2353	YceI-like domain
AMD06_RS05175	COG3052	prosthetic group binding
AMD06_RS05200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMD06_RS05210	COG1802	Transcriptional regulator
AMD06_RS05265	COG2963	transposase activity
AMD06_RS05270	COG4221	oxidoreductase activity
AMD06_RS05285	COG4221	oxidoreductase activity
AMD06_RS05295	COG0435	Glutathione S-transferase
AMD06_RS05320	COG2963	transposase activity
AMD06_RS05340	COG0308	aminopeptidase N
AMD06_RS05350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD06_RS05365	COG4948	Mandelate Racemase Muconate Lactonizing
AMD06_RS05370	COG3250	beta-galactosidase activity
AMD06_RS05395	COG1970	mechanosensitive ion channel activity
AMD06_RS05415	COG0471	metal ion transport
AMD06_RS05415	COG3273	potassium ion transport
AMD06_RS05420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMD06_RS05425	COG2022	thiamine diphosphate biosynthetic process
AMD06_RS05520	COG2003	Belongs to the UPF0758 family
AMD06_RS05555	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AMD06_RS05650	COG0745	RESPONSE REGULATOR receiver
AMD06_RS05655	COG5002	protein histidine kinase activity
AMD06_RS05660	COG2801	Transposase and inactivated derivatives
AMD06_RS05665	COG2963	transposase activity
AMD06_RS05680	COG0237	dephospho-CoA kinase activity
AMD06_RS05685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AMD06_RS05725	COG0045	succinate-CoA ligase (ADP-forming) activity
AMD06_RS05730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AMD06_RS05755	COG2369	cell adhesion
AMD06_RS05805	COG2963	transposase activity
AMD06_RS05810	COG2801	Transposase and inactivated derivatives
AMD06_RS05970	COG4191	Histidine kinase
AMD06_RS05970	COG0784	Response regulator, receiver
AMD06_RS06035	COG4695	Portal protein
AMD06_RS06055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMD06_RS06065	COG3852	Histidine kinase
AMD06_RS06075	COG0544	peptidyl-prolyl cis-trans isomerase activity
AMD06_RS06085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMD06_RS06115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD06_RS06125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD06_RS06135	COG0328	RNA-DNA hybrid ribonuclease activity
AMD06_RS06140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD06_RS06145	COG0631	protein serine/threonine phosphatase activity
AMD06_RS06160	COG0859	PFAM glycosyl transferase family 9
AMD06_RS06165	COG3642	lipopolysaccharide core region biosynthetic process
AMD06_RS06170	COG1234	tRNA 3'-trailer cleavage
AMD06_RS06175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMD06_RS06185	COG0315	cyclic pyranopterin monophosphate synthase activity
AMD06_RS06190	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AMD06_RS06195	COG0314	molybdopterin synthase activity
AMD06_RS06205	COG2963	transposase activity
AMD06_RS06210	COG2801	Transposase and inactivated derivatives
AMD06_RS06245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMD06_RS06250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMD06_RS06255	COG0537	adenosine 5'-monophosphoramidase activity
AMD06_RS06275	COG0714	Associated with various cellular activities
AMD06_RS06300	COG0424	maF-like protein
AMD06_RS06305	COG1399	metal-binding, possibly nucleic acid-binding protein
AMD06_RS06310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMD06_RS06315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD06_RS06330	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS06345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMD06_RS06350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMD06_RS06375	COG3829	transcription factor binding
AMD06_RS06395	COG3609	addiction module antidote protein, CC2985 family
AMD06_RS06415	COG2373	Large extracellular alpha-helical protein
AMD06_RS06430	COG4953	penicillin-binding protein 1C
AMD06_RS06440	COG0678	peroxiredoxin activity
AMD06_RS06460	COG0330	HflC and HflK could
AMD06_RS06465	COG0330	HflC and HflK could
AMD06_RS06475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMD06_RS06480	COG0308	aminopeptidase N
AMD06_RS06490	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS06495	COG1309	transcriptional regulator
AMD06_RS06570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMD06_RS06580	COG3387	PFAM Glycoside hydrolase 15-related
AMD06_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS06590	COG3537	Alpha-1,2-mannosidase
AMD06_RS06610	COG0492	ferredoxin-NADP+ reductase activity
AMD06_RS06635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMD06_RS06640	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMD06_RS06645	COG2080	2 iron, 2 sulfur cluster binding
AMD06_RS06680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMD06_RS06695	COG0587	DNA-directed DNA polymerase activity
AMD06_RS06710	COG1297	OPT oligopeptide transporter protein
AMD06_RS06725	COG1506	peptidase
AMD06_RS06725	COG0823	Involved in the tonB-independent uptake of proteins
AMD06_RS06740	COG2207	Transcriptional regulator
AMD06_RS06740	COG1917	Cupin 2, conserved barrel domain protein
AMD06_RS06765	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AMD06_RS06775	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AMD06_RS06780	COG0745	RESPONSE REGULATOR receiver
AMD06_RS06785	COG2205	protein histidine kinase activity
AMD06_RS06795	COG4452	Inner membrane protein CreD
AMD06_RS06820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD06_RS06825	COG0735	belongs to the Fur family
AMD06_RS06840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD06_RS06850	COG1309	transcriptional regulator
AMD06_RS06860	COG2207	Transcriptional regulator
AMD06_RS06870	COG0583	DNA-binding transcription factor activity
AMD06_RS06875	COG2814	Major facilitator Superfamily
AMD06_RS06880	COG0667	Aldo Keto reductase
AMD06_RS06995	COG5001	Diguanylate cyclase
AMD06_RS06995	COG5002	protein histidine kinase activity
AMD06_RS07000	COG1187	pseudouridine synthase activity
AMD06_RS07025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMD06_RS07035	COG0475	glutathione-regulated potassium exporter activity
AMD06_RS07040	COG5002	protein histidine kinase activity
AMD06_RS07040	COG5000	phosphorelay sensor kinase activity
AMD06_RS07045	COG0745	RESPONSE REGULATOR receiver
AMD06_RS07050	COG1538	Outer membrane efflux protein
AMD06_RS07075	COG1132	(ABC) transporter
AMD06_RS07120	COG2155	Conserved Protein
AMD06_RS07145	COG3118	belongs to the thioredoxin family
AMD06_RS07155	COG0495	leucyl-tRNA aminoacylation
AMD06_RS07170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMD06_RS07185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AMD06_RS07200	COG2968	Membrane
AMD06_RS07205	COG0424	maF-like protein
AMD06_RS07215	COG3164	Protein of unknown function
AMD06_RS07225	COG0312	modulator of DNA gyrase
AMD06_RS07230	COG3028	Belongs to the UPF0307 family
AMD06_RS07235	COG0312	modulator of DNA gyrase
AMD06_RS07245	COG4104	PAAR repeat-containing protein
AMD06_RS07250	COG0142	geranyltranstransferase activity
AMD06_RS07255	COG1722	exodeoxyribonuclease VII activity
AMD06_RS07260	COG0037	tRNA processing
AMD06_RS07265	COG1785	Belongs to the alkaline phosphatase family
AMD06_RS07270	COG1301	dicarboxylic acid transport
AMD06_RS07275	COG4106	trans-aconitate 2-methyltransferase activity
AMD06_RS07285	COG0791	NLP P60 protein
AMD06_RS07290	COG0791	NLP P60 protein
AMD06_RS07295	COG1047	Peptidyl-prolyl cis-trans
AMD06_RS07300	COG2311	Membrane
AMD06_RS07305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD06_RS07310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMD06_RS07330	COG3590	peptidase
AMD06_RS07335	COG3590	peptidase
AMD06_RS07355	COG0489	protein tyrosine kinase activity
AMD06_RS07360	COG0717	Belongs to the dCTP deaminase family
AMD06_RS07385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMD06_RS07390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD06_RS07405	COG0494	nUDIX hydrolase
AMD06_RS07410	COG0433	COG0433 Predicted ATPase
AMD06_RS07420	COG0688	phosphatidylethanolamine metabolic process
AMD06_RS07430	COG2890	protein-(glutamine-N5) methyltransferase activity
AMD06_RS07435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AMD06_RS07440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMD06_RS07445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AMD06_RS07465	COG0101	tRNA pseudouridine synthase activity
AMD06_RS07470	COG0135	phosphoribosylanthranilate isomerase activity
AMD06_RS07480	COG0133	tryptophan synthase activity
AMD06_RS07490	COG0159	tryptophan synthase activity
AMD06_RS07495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AMD06_RS07500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD06_RS07535	COG0300	oxidoreductase activity
AMD06_RS07540	COG0149	triose-phosphate isomerase activity
AMD06_RS07555	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD06_RS07560	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD06_RS07565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD06_RS07570	COG0649	NAD binding
AMD06_RS07575	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AMD06_RS07580	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AMD06_RS07590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AMD06_RS07595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD06_RS07620	COG1007	ATP synthesis coupled electron transport
AMD06_RS07630	COG0779	Required for maturation of 30S ribosomal subunits
AMD06_RS07635	COG0195	Participates in both transcription termination and antitermination
AMD06_RS07640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AMD06_RS07645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AMD06_RS07650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMD06_RS07655	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMD06_RS07660	COG1185	polyribonucleotide nucleotidyltransferase activity
AMD06_RS07695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AMD06_RS07705	COG2095	MarC family integral membrane protein
AMD06_RS07715	COG1611	Belongs to the LOG family
AMD06_RS07720	COG3275	phosphorelay sensor kinase activity
AMD06_RS07760	COG2963	transposase activity
AMD06_RS07795	COG2003	Belongs to the UPF0758 family
AMD06_RS07800	COG5489	Protein of unknown function (DUF736)
AMD06_RS07805	COG1396	sequence-specific DNA binding
AMD06_RS07810	COG2963	transposase activity
AMD06_RS07820	COG3002	Belongs to the UPF0753 family
AMD06_RS07825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMD06_RS07830	COG0583	DNA-binding transcription factor activity
AMD06_RS07850	COG2197	response regulator
AMD06_RS07865	COG1335	isochorismatase
AMD06_RS07885	COG2814	Major facilitator Superfamily
AMD06_RS07900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMD06_RS07900	COG1648	precorrin-2 dehydrogenase activity
AMD06_RS07915	COG3685	Protein conserved in bacteria
AMD06_RS07930	COG5001	Diguanylate cyclase
AMD06_RS07940	COG4566	intracellular signal transduction
AMD06_RS07990	COG3279	Response regulator of the LytR AlgR family
AMD06_RS08025	COG1238	metal cluster binding
AMD06_RS08035	COG2963	transposase activity
AMD06_RS08040	COG2801	Transposase and inactivated derivatives
AMD06_RS08100	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS08110	COG1073	alpha beta
AMD06_RS08110	COG2226	methyltransferase
AMD06_RS08155	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AMD06_RS08155	COG0316	Belongs to the HesB IscA family
AMD06_RS08160	COG2154	pterin-4-alpha-carbinolamine dehydratase
AMD06_RS08170	COG0428	transporter
AMD06_RS08175	COG3064	Membrane
AMD06_RS08185	COG1530	ribonuclease E activity
AMD06_RS08195	COG1054	Belongs to the UPF0176 family
AMD06_RS08215	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AMD06_RS08225	COG0582	viral genome integration into host DNA
AMD06_RS08230	COG2963	transposase activity
AMD06_RS08235	COG2801	Transposase and inactivated derivatives
AMD06_RS08250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD06_RS08255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD06_RS08285	COG3039	Transposase
AMD06_RS08325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMD06_RS08340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMD06_RS08405	COG0629	single-stranded DNA binding
AMD06_RS08410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMD06_RS08415	COG0270	DNA (cytosine-5-)-methyltransferase activity
AMD06_RS08460	COG2826	transposase and inactivated derivatives, IS30 family
AMD06_RS08585	COG2003	Belongs to the UPF0758 family
AMD06_RS08675	COG0583	DNA-binding transcription factor activity
AMD06_RS08680	COG1396	sequence-specific DNA binding
AMD06_RS08700	COG0582	viral genome integration into host DNA
AMD06_RS08710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD06_RS08715	COG0322	excinuclease ABC activity
AMD06_RS08725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMD06_RS08730	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AMD06_RS08735	COG1663	tetraacyldisaccharide 4'-kinase activity
AMD06_RS08740	COG1132	(ABC) transporter
AMD06_RS08750	COG0811	peptide transport
AMD06_RS08765	COG1136	(ABC) transporter
AMD06_RS08770	COG4591	ABC-type transport system involved in lipoprotein release permease component
AMD06_RS08780	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AMD06_RS08785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMD06_RS08800	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AMD06_RS08820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AMD06_RS08825	COG0837	glucose binding
AMD06_RS08830	COG0363	glucosamine-6-phosphate deaminase activity
AMD06_RS08835	COG0129	dihydroxy-acid dehydratase activity
AMD06_RS08840	COG0800	Aldolase
AMD06_RS08905	COG0784	Response regulator, receiver
AMD06_RS08905	COG2205	protein histidine kinase activity
AMD06_RS08910	COG2183	response to ionizing radiation
AMD06_RS08920	COG0723	plastoquinol--plastocyanin reductase activity
AMD06_RS08920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD06_RS08935	COG3243	poly(R)-hydroxyalkanoic acid synthase
AMD06_RS08945	COG1183	phosphatidylcholine synthase activity
AMD06_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS08965	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AMD06_RS08975	COG0668	transmembrane transport
AMD06_RS08980	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AMD06_RS08995	COG1914	H( )-stimulated, divalent metal cation uptake system
AMD06_RS09010	COG0746	molybdenum cofactor guanylyltransferase activity
AMD06_RS09015	COG0303	'Molybdopterin
AMD06_RS09025	COG0708	Exodeoxyribonuclease III
AMD06_RS09060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMD06_RS09065	COG0303	'Molybdopterin
AMD06_RS09070	COG1160	GTP binding
AMD06_RS09075	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD06_RS09085	COG1426	Protein conserved in bacteria
AMD06_RS09095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMD06_RS09110	COG1024	Enoyl-CoA hydratase
AMD06_RS09110	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD06_RS09115	COG0183	Belongs to the thiolase family
AMD06_RS09125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMD06_RS09130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AMD06_RS09140	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AMD06_RS09150	COG1674	ftsk spoiiie
AMD06_RS09155	COG0492	ferredoxin-NADP+ reductase activity
AMD06_RS09165	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AMD06_RS09175	COG0542	response to heat
AMD06_RS09190	COG0482	sulfurtransferase activity
AMD06_RS09195	COG2915	High frequency lysogenization protein hflD homolog
AMD06_RS09225	COG5002	protein histidine kinase activity
AMD06_RS09245	COG0835	chemotaxis
AMD06_RS09245	COG0784	Response regulator, receiver
AMD06_RS09255	COG1558	bacterial-type flagellum-dependent cell motility
AMD06_RS09260	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AMD06_RS09270	COG4787	bacterial-type flagellum-dependent cell motility
AMD06_RS09280	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AMD06_RS09285	COG1706	bacterial-type flagellum-dependent cell motility
AMD06_RS09290	COG3951	Flagellar rod assembly protein muramidase FlgJ
AMD06_RS09290	COG1705	Flagellar rod assembly protein muramidase FlgJ
AMD06_RS09300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AMD06_RS09305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AMD06_RS09310	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AMD06_RS09340	COG2201	protein-glutamate methylesterase activity
AMD06_RS09360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD06_RS09365	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS09400	COG1677	Flagellar hook-basal body complex protein FliE
AMD06_RS09450	COG3190	flagellar
AMD06_RS09470	COG1684	flagellar biosynthetic protein fliR
AMD06_RS09500	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AMD06_RS09530	COG0784	Response regulator, receiver
AMD06_RS09530	COG2198	Histidine kinase
AMD06_RS09530	COG0643	Histidine kinase
AMD06_RS09540	COG0641	radical SAM
AMD06_RS09560	COG2963	transposase activity
AMD06_RS09565	COG2801	Transposase and inactivated derivatives
AMD06_RS09610	COG0210	DNA helicase
AMD06_RS09690	COG2084	Dehydrogenase
AMD06_RS09710	COG2003	Belongs to the UPF0758 family
AMD06_RS09745	COG0582	viral genome integration into host DNA
AMD06_RS09750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD06_RS09750	COG0519	Catalyzes the synthesis of GMP from XMP
AMD06_RS09760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMD06_RS09770	COG0475	glutathione-regulated potassium exporter activity
AMD06_RS09770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMD06_RS09775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMD06_RS09785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMD06_RS09790	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AMD06_RS09800	COG0776	regulation of translation
AMD06_RS09805	COG0539	negative regulation of cytoplasmic translation
AMD06_RS09810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AMD06_RS09825	COG2957	Belongs to the agmatine deiminase family
AMD06_RS09830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD06_RS09855	COG0395	ABC-type sugar transport system, permease component
AMD06_RS09860	COG1175	transmembrane transport
AMD06_RS09890	COG2350	Protein conserved in bacteria
AMD06_RS09895	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AMD06_RS09900	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMD06_RS09905	COG1187	pseudouridine synthase activity
AMD06_RS09925	COG0436	Aminotransferase
AMD06_RS09930	COG4133	protoheme IX ABC transporter activity
AMD06_RS09950	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AMD06_RS09955	COG1138	Cytochrome C-type biogenesis protein
AMD06_RS09975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD06_RS09980	COG1278	Cold shock
AMD06_RS09985	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AMD06_RS09990	COG4988	ABC transporter
AMD06_RS10000	COG1294	oxidase, subunit
AMD06_RS10025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AMD06_RS10030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AMD06_RS10040	COG0165	Argininosuccinate lyase
AMD06_RS10045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AMD06_RS10055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMD06_RS10060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMD06_RS10070	COG0137	argininosuccinate synthase activity
AMD06_RS10075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMD06_RS10085	COG0215	cysteine-tRNA ligase activity
AMD06_RS10090	COG2166	iron-sulfur cluster assembly
AMD06_RS10110	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AMD06_RS10115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMD06_RS10140	COG4302	ethanolamine ammonia-lyase activity
AMD06_RS10170	COG2963	transposase activity
AMD06_RS10190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMD06_RS10195	COG0402	S-adenosylhomocysteine deaminase activity
AMD06_RS10205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMD06_RS10210	COG1509	lysine 2,3-aminomutase activity
AMD06_RS10215	COG5001	Diguanylate cyclase
AMD06_RS10215	COG3300	MHYT domain
AMD06_RS10230	COG0483	inositol monophosphate 1-phosphatase activity
AMD06_RS10235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AMD06_RS10250	COG0488	(ABC) transporter
AMD06_RS10255	COG0513	Belongs to the DEAD box helicase family
AMD06_RS10260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMD06_RS10265	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AMD06_RS10275	COG0625	glutathione transferase activity
AMD06_RS10285	COG4681	YaeQ
AMD06_RS10290	COG2081	HI0933 family
AMD06_RS10300	COG0501	Belongs to the peptidase M48B family
AMD06_RS10305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD06_RS10310	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS10330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AMD06_RS10335	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMD06_RS10340	COG0802	atpase or kinase
AMD06_RS10345	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMD06_RS10345	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AMD06_RS10350	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMD06_RS10355	COG1570	exodeoxyribonuclease VII activity
AMD06_RS10365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMD06_RS10545	COG0835	chemotaxis
AMD06_RS10550	COG0840	transmembrane signaling receptor activity
AMD06_RS10555	COG2094	Belongs to the DNA glycosylase MPG family
AMD06_RS10560	COG1201	RNA secondary structure unwinding
AMD06_RS10575	COG2969	positive regulation of protein catabolic process
AMD06_RS10580	COG0625	glutathione transferase activity
AMD06_RS10585	COG2857	Cytochrome c1
AMD06_RS10590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AMD06_RS10595	COG0723	plastoquinol--plastocyanin reductase activity
AMD06_RS10600	COG0741	lytic transglycosylase activity
AMD06_RS10615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMD06_RS10620	COG1702	phosphate starvation-inducible protein PhoH
AMD06_RS10630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMD06_RS10640	COG4535	Mg2 and Co2 transporter CorC
AMD06_RS10655	COG1012	belongs to the aldehyde dehydrogenase family
AMD06_RS10665	COG1177	transmembrane transport
AMD06_RS10670	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMD06_RS10675	COG3842	ATPase activity
AMD06_RS10695	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AMD06_RS10710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMD06_RS10715	COG0174	glutamine synthetase
AMD06_RS10720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD06_RS10730	COG2703	oxygen carrier activity
AMD06_RS10735	COG0477	Major facilitator Superfamily
AMD06_RS10745	COG0243	molybdopterin cofactor binding
AMD06_RS10750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMD06_RS10755	COG2223	nitrite transmembrane transporter activity
AMD06_RS10765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMD06_RS10775	COG2733	membrane
AMD06_RS10780	COG5002	protein histidine kinase activity
AMD06_RS10780	COG2205	protein histidine kinase activity
AMD06_RS10780	COG0784	Response regulator, receiver
AMD06_RS10790	COG0477	Major facilitator Superfamily
AMD06_RS10795	COG2902	Dehydrogenase
AMD06_RS10805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD06_RS10810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD06_RS10815	COG1609	Transcriptional regulator
AMD06_RS10820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD06_RS10820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMD06_RS10825	COG1105	Belongs to the carbohydrate kinase PfkB family
AMD06_RS10830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMD06_RS10830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMD06_RS10865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMD06_RS10875	COG1862	Preprotein translocase
AMD06_RS10880	COG0343	queuine tRNA-ribosyltransferase activity
AMD06_RS10885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMD06_RS10925	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AMD06_RS10930	COG3291	Pkd domain containing protein
AMD06_RS10940	COG0405	Gamma-glutamyltransferase
AMD06_RS10945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMD06_RS10960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMD06_RS10965	COG0742	ribosomal rna small subunit methyltransferase
AMD06_RS10970	COG0326	Molecular chaperone. Has ATPase activity
AMD06_RS11040	COG0531	amino acid
AMD06_RS11055	COG0006	proline dipeptidase activity
AMD06_RS11065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMD06_RS11080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD06_RS11085	COG3938	Belongs to the proline racemase family
AMD06_RS11095	COG0552	protein localization to endoplasmic reticulum
AMD06_RS11100	COG1194	a g-specific adenine glycosylase
AMD06_RS11105	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AMD06_RS11110	COG0784	Response regulator, receiver
AMD06_RS11110	COG4191	Histidine kinase
AMD06_RS11125	COG0322	excinuclease ABC activity
AMD06_RS11140	COG3040	lipid binding
AMD06_RS11150	COG1960	acyl-CoA dehydrogenase activity
AMD06_RS11160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AMD06_RS11180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD06_RS11185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD06_RS11190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD06_RS11215	COG0438	transferase activity, transferring glycosyl groups
AMD06_RS11225	COG0438	transferase activity, transferring glycosyl groups
AMD06_RS11230	COG0438	transferase activity, transferring glycosyl groups
AMD06_RS11280	COG0072	phenylalanine-tRNA ligase activity
AMD06_RS11280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD06_RS11285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMD06_RS11300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AMD06_RS11305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMD06_RS11330	COG1082	Xylose isomerase domain protein TIM barrel
AMD06_RS11345	COG0366	Alpha amylase catalytic
AMD06_RS11350	COG2963	transposase activity
AMD06_RS11355	COG2801	Transposase and inactivated derivatives
AMD06_RS11365	COG0477	Major facilitator Superfamily
AMD06_RS11370	COG2115	Belongs to the xylose isomerase family
AMD06_RS11375	COG1070	Carbohydrate kinase
AMD06_RS11385	COG1501	Belongs to the glycosyl hydrolase 31 family
AMD06_RS11425	COG0800	Aldolase
AMD06_RS11430	COG4948	Mandelate Racemase Muconate Lactonizing
AMD06_RS11440	COG3734	2-keto-3-deoxy-galactonokinase
AMD06_RS11445	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMD06_RS11455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMD06_RS11470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMD06_RS11475	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AMD06_RS11490	COG0352	thiamine-phosphate diphosphorylase activity
AMD06_RS11490	COG0351	phosphomethylpyrimidine kinase
AMD06_RS11515	COG0583	DNA-binding transcription factor activity
AMD06_RS11525	COG1741	Belongs to the pirin family
AMD06_RS11540	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AMD06_RS11545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMD06_RS11550	COG2137	regulation of response to DNA damage stimulus
AMD06_RS11555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMD06_RS11560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMD06_RS11570	COG1546	Belongs to the CinA family
AMD06_RS11575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMD06_RS11585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMD06_RS11590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMD06_RS11600	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AMD06_RS11605	COG1534	Rna-binding protein
AMD06_RS11620	COG1238	metal cluster binding
AMD06_RS11625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMD06_RS11630	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AMD06_RS11635	COG2840	Smr protein MutS2
AMD06_RS11640	COG0585	pseudouridine synthase activity
AMD06_RS11645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMD06_RS11650	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMD06_RS11655	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AMD06_RS11660	COG0148	phosphopyruvate hydratase activity
AMD06_RS11670	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AMD06_RS11675	COG0504	CTP synthase activity
AMD06_RS11700	COG0306	phosphate transporter
AMD06_RS11710	COG1253	flavin adenine dinucleotide binding
AMD06_RS11725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD06_RS11730	COG0477	Major facilitator Superfamily
AMD06_RS11740	COG1136	(ABC) transporter
AMD06_RS11755	COG0438	transferase activity, transferring glycosyl groups
AMD06_RS11765	COG2264	protein methyltransferase activity
AMD06_RS11795	COG2244	polysaccharide biosynthetic process
AMD06_RS11850	COG1595	DNA-templated transcription, initiation
AMD06_RS11865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMD06_RS11875	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AMD06_RS11885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD06_RS11900	COG0784	Response regulator, receiver
AMD06_RS11900	COG4191	Histidine kinase
AMD06_RS11905	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AMD06_RS11940	COG0840	transmembrane signaling receptor activity
AMD06_RS11965	COG2963	transposase activity
AMD06_RS11970	COG1396	sequence-specific DNA binding
AMD06_RS11975	COG5489	Protein of unknown function (DUF736)
AMD06_RS11980	COG2003	Belongs to the UPF0758 family
AMD06_RS12005	COG0582	viral genome integration into host DNA
AMD06_RS12020	COG4774	siderophore transport
AMD06_RS12035	COG2336	PFAM SpoVT AbrB
AMD06_RS12060	COG4206	TonB-dependent receptor
AMD06_RS12080	COG2273	Hydrolase Family 16
AMD06_RS12080	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AMD06_RS12095	COG2274	protein secretion by the type I secretion system
AMD06_RS12150	COG0270	DNA (cytosine-5-)-methyltransferase activity
AMD06_RS12200	COG4804	nuclease activity
AMD06_RS12205	COG2963	transposase activity
AMD06_RS12285	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AMD06_RS12290	COG1360	Flagellar Motor Protein
AMD06_RS12300	COG0835	chemotaxis
AMD06_RS12310	COG0745	RESPONSE REGULATOR receiver
AMD06_RS12315	COG0643	Histidine kinase
AMD06_RS12315	COG2198	Histidine kinase
AMD06_RS12320	COG0840	transmembrane signaling receptor activity
AMD06_RS12335	COG0840	transmembrane signaling receptor activity
AMD06_RS12345	COG0840	transmembrane signaling receptor activity
AMD06_RS12350	COG0840	transmembrane signaling receptor activity
AMD06_RS12355	COG0840	transmembrane signaling receptor activity
AMD06_RS12360	COG0840	transmembrane signaling receptor activity
AMD06_RS12370	COG0840	transmembrane signaling receptor activity
AMD06_RS12375	COG0840	transmembrane signaling receptor activity
AMD06_RS12380	COG0840	transmembrane signaling receptor activity
AMD06_RS12385	COG0840	transmembrane signaling receptor activity
AMD06_RS12390	COG0840	transmembrane signaling receptor activity
AMD06_RS12400	COG0835	chemotaxis
AMD06_RS12410	COG0840	transmembrane signaling receptor activity
AMD06_RS12420	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AMD06_RS12425	COG2201	protein-glutamate methylesterase activity
AMD06_RS12435	COG2267	carboxylic ester hydrolase activity
AMD06_RS12465	COG0318	PFAM AMP-dependent synthetase and ligase
AMD06_RS12470	COG1024	Enoyl-CoA hydratase
AMD06_RS12475	COG0784	Response regulator, receiver
AMD06_RS12475	COG2205	protein histidine kinase activity
AMD06_RS12475	COG2198	Histidine kinase
AMD06_RS12485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMD06_RS12490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMD06_RS12495	COG3279	Response regulator of the LytR AlgR family
AMD06_RS12540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMD06_RS12550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD06_RS12555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AMD06_RS12565	COG0505	Belongs to the CarA family
AMD06_RS12570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMD06_RS12575	COG2258	MOSC domain
AMD06_RS12580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMD06_RS12625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMD06_RS12645	COG0277	FAD linked oxidase domain protein
AMD06_RS12650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMD06_RS12660	COG0531	amino acid
AMD06_RS12665	COG0531	amino acid
AMD06_RS12670	COG0235	Class ii aldolase
AMD06_RS12675	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AMD06_RS12680	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AMD06_RS12695	COG0140	phosphoribosyl-ATP diphosphatase activity
AMD06_RS12695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMD06_RS12700	COG0107	imidazoleglycerol-phosphate synthase activity
AMD06_RS12705	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AMD06_RS12710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMD06_RS12715	COG0131	Imidazoleglycerol-phosphate dehydratase
AMD06_RS12715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AMD06_RS12720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMD06_RS12725	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMD06_RS12730	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMD06_RS12740	COG0124	histidyl-tRNA synthetase
AMD06_RS12745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD06_RS12785	COG3210	domain, Protein
AMD06_RS12790	COG3210	domain, Protein
AMD06_RS12805	COG0726	polysaccharide deacetylase
AMD06_RS12805	COG1649	PFAM Uncharacterised BCR, COG1649
AMD06_RS12810	COG1215	transferase activity, transferring glycosyl groups
AMD06_RS12825	COG1012	belongs to the aldehyde dehydrogenase family
AMD06_RS12840	COG0167	dihydroorotate dehydrogenase activity
AMD06_RS12845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMD06_RS12850	COG0697	spore germination
AMD06_RS12855	COG1794	racemase activity, acting on amino acids and derivatives
AMD06_RS12865	COG0671	phosphoesterase, PA-phosphatase related
AMD06_RS12870	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AMD06_RS12880	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AMD06_RS12885	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD06_RS12890	COG4251	negative regulation of phosphorylation
AMD06_RS12890	COG5001	Diguanylate cyclase
AMD06_RS12890	COG3706	GGDEF domain
AMD06_RS12890	COG2203	Gaf domain
AMD06_RS12900	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD06_RS12920	COG0166	Belongs to the GPI family
AMD06_RS12925	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AMD06_RS12930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AMD06_RS12935	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMD06_RS12955	COG1469	GTP cyclohydrolase I activity
AMD06_RS12960	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMD06_RS12965	COG0366	Alpha amylase catalytic
AMD06_RS12970	COG2963	transposase activity
AMD06_RS12975	COG2801	Transposase and inactivated derivatives
AMD06_RS13035	COG2948	multi-organism process
AMD06_RS13055	COG3505	Type IV secretory pathway VirD4
AMD06_RS13070	COG0556	nucleotide-excision repair
AMD06_RS13105	COG2963	transposase activity
AMD06_RS13145	COG0583	DNA-binding transcription factor activity
AMD06_RS13150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMD06_RS13155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMD06_RS13170	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMD06_RS13175	COG1605	Chorismate mutase
AMD06_RS13175	COG0077	Prephenate dehydratase
AMD06_RS13180	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AMD06_RS13185	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AMD06_RS13190	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AMD06_RS13235	COG1228	amidohydrolase
AMD06_RS13240	COG2986	histidine ammonia-lyase
AMD06_RS13250	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AMD06_RS13265	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMD06_RS13275	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AMD06_RS13280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMD06_RS13285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMD06_RS13295	COG3115	cell septum assembly
AMD06_RS13305	COG0359	binds to the 23S rRNA
AMD06_RS13310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMD06_RS13315	COG0360	Binds together with S18 to 16S ribosomal RNA
AMD06_RS13320	COG0316	Belongs to the HesB IscA family
AMD06_RS13325	COG0017	Asparaginyl-tRNA synthetase
AMD06_RS13345	COG2808	Putative FMN-binding domain
AMD06_RS13405	COG0288	reversible hydration of carbon dioxide
AMD06_RS13410	COG0662	Cupin 2, conserved barrel domain protein
AMD06_RS13420	COG3844	kynureninase activity
AMD06_RS13425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD06_RS13430	COG2925	Exonuclease
AMD06_RS13455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMD06_RS13460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AMD06_RS13460	COG0116	Belongs to the methyltransferase superfamily
AMD06_RS13465	COG0488	(ABC) transporter
AMD06_RS13500	COG0494	nUDIX hydrolase
AMD06_RS13510	COG1024	Enoyl-CoA hydratase
AMD06_RS13520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMD06_RS13525	COG0659	secondary active sulfate transmembrane transporter activity
AMD06_RS13550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AMD06_RS13555	COG0573	inorganic phosphate transmembrane transporter activity
AMD06_RS13560	COG0581	inorganic phosphate transmembrane transporter activity
AMD06_RS13565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMD06_RS13570	COG0704	Plays a role in the regulation of phosphate uptake
AMD06_RS13580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD06_RS13590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD06_RS13600	COG0557	exoribonuclease II activity
AMD06_RS13615	COG1960	acyl-CoA dehydrogenase activity
AMD06_RS13620	COG2226	methyltransferase
AMD06_RS13625	COG1410	methionine synthase
AMD06_RS13625	COG0646	methionine synthase
AMD06_RS13630	COG0646	methionine synthase
AMD06_RS13630	COG1410	methionine synthase
AMD06_RS13640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD06_RS13665	COG2900	Belongs to the SlyX family
AMD06_RS13680	COG0386	Belongs to the glutathione peroxidase family
AMD06_RS13685	COG1725	Transcriptional regulator
AMD06_RS13690	COG1131	(ABC) transporter
AMD06_RS13720	COG1253	flavin adenine dinucleotide binding
AMD06_RS13740	COG2850	peptidyl-arginine hydroxylation
AMD06_RS13775	COG1132	(ABC) transporter
AMD06_RS13780	COG0583	DNA-binding transcription factor activity
AMD06_RS13810	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AMD06_RS13815	COG0484	heat shock protein binding
AMD06_RS13820	COG0443	Heat shock 70 kDa protein
AMD06_RS13825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMD06_RS13830	COG1420	regulation of RNA biosynthetic process
AMD06_RS13835	COG0497	DNA recombination
AMD06_RS13845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD06_RS13860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMD06_RS13970	COG3706	GGDEF domain
AMD06_RS14015	COG0583	DNA-binding transcription factor activity
AMD06_RS14025	COG0415	Belongs to the DNA photolyase family
AMD06_RS14030	COG0305	Participates in initiation and elongation during chromosome replication
AMD06_RS14040	COG0367	asparagine synthase
AMD06_RS14060	COG1960	acyl-CoA dehydrogenase activity
AMD06_RS14075	COG0084	hydrolase, TatD family'
AMD06_RS14080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AMD06_RS14135	COG0386	Belongs to the glutathione peroxidase family
AMD06_RS14140	COG0339	signal peptide processing
AMD06_RS14190	COG2814	Major facilitator Superfamily
AMD06_RS14195	COG1566	PFAM secretion protein HlyD family protein
AMD06_RS14225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMD06_RS14240	COG4774	siderophore transport
AMD06_RS14250	COG0367	asparagine synthase
AMD06_RS14255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMD06_RS14260	COG1393	Belongs to the ArsC family
AMD06_RS14270	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AMD06_RS14310	COG0052	Belongs to the universal ribosomal protein uS2 family
AMD06_RS14315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMD06_RS14325	COG0528	UMP kinase activity
AMD06_RS14330	COG0233	cytoplasmic translational termination
AMD06_RS14335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMD06_RS14340	COG0575	Belongs to the CDS family
AMD06_RS14345	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMD06_RS14350	COG0750	zinc metalloprotease
AMD06_RS14365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD06_RS14370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD06_RS14375	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD06_RS14380	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD06_RS14385	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMD06_RS14395	COG0825	malonyl-CoA metabolic process
AMD06_RS14410	COG1981	membrane
AMD06_RS14430	COG1695	Transcriptional regulator
AMD06_RS14450	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AMD06_RS14460	COG2040	homocysteine
AMD06_RS14465	COG0833	amino acid
AMD06_RS14470	COG0346	lactoylglutathione lyase activity
AMD06_RS14475	COG1131	(ABC) transporter
AMD06_RS14490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD06_RS14490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD06_RS14500	COG2878	Part of a membrane complex involved in electron transport
AMD06_RS14520	COG1595	DNA-templated transcription, initiation
AMD06_RS14545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMD06_RS14560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMD06_RS14565	COG0251	oxidation-reduction process
AMD06_RS14575	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMD06_RS14575	COG0392	lysyltransferase activity
AMD06_RS14610	COG2814	Major facilitator Superfamily
AMD06_RS14615	COG1902	pentaerythritol trinitrate reductase activity
AMD06_RS14620	COG2824	Alkylphosphonate utilization operon protein PhnA
AMD06_RS14630	COG1047	Peptidyl-prolyl cis-trans
AMD06_RS14635	COG1077	Cell shape determining protein MreB Mrl
AMD06_RS14655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AMD06_RS14665	COG5487	UPF0391 membrane protein
AMD06_RS14670	COG1451	nucleotide metabolic process
AMD06_RS14690	COG0183	Belongs to the thiolase family
AMD06_RS14720	COG1793	dna ligase
AMD06_RS14720	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AMD06_RS14730	COG1793	dna ligase
AMD06_RS14735	COG1201	RNA secondary structure unwinding
AMD06_RS14745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD06_RS14750	COG1278	Cold shock
AMD06_RS14755	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AMD06_RS14760	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AMD06_RS14765	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD06_RS14770	COG3046	protein related to deoxyribodipyrimidine photolyase
AMD06_RS14775	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AMD06_RS14780	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMD06_RS14785	COG2954	triphosphatase activity
AMD06_RS14790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMD06_RS14800	COG1381	Involved in DNA repair and RecF pathway recombination
AMD06_RS14805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMD06_RS14810	COG0571	ribonuclease III activity
AMD06_RS14825	COG0481	GTPase activity
AMD06_RS14830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD06_RS14845	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD06_RS14845	COG1024	Enoyl-CoA hydratase
AMD06_RS14865	COG1024	Enoyl-CoA hydratase
AMD06_RS14870	COG1960	acyl-CoA dehydrogenase activity
AMD06_RS14890	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AMD06_RS14895	COG3250	beta-galactosidase activity
AMD06_RS14915	COG3209	COG3209 Rhs family protein
AMD06_RS14925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AMD06_RS14935	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMD06_RS14960	COG0534	Mate efflux family protein
AMD06_RS14965	COG0335	large ribosomal subunit rRNA binding
AMD06_RS14970	COG0336	Belongs to the RNA methyltransferase TrmD family
AMD06_RS14975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AMD06_RS14980	COG0228	four-way junction DNA binding
AMD06_RS14985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMD06_RS14995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMD06_RS15000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMD06_RS15030	COG4191	Histidine kinase
AMD06_RS15030	COG0784	Response regulator, receiver
AMD06_RS15035	COG2205	protein histidine kinase activity
AMD06_RS15035	COG3437	response regulator, receiver
AMD06_RS15035	COG4999	Histidine kinase
AMD06_RS15035	COG3850	Histidine kinase
AMD06_RS15040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AMD06_RS15050	COG2205	protein histidine kinase activity
AMD06_RS15055	COG5507	3-demethylubiquinone-9 3-methyltransferase
AMD06_RS15065	COG4771	TonB-dependent receptor
AMD06_RS15090	COG2172	sigma factor antagonist activity
AMD06_RS15095	COG1366	Belongs to the anti-sigma-factor antagonist family
AMD06_RS15100	COG1366	Belongs to the anti-sigma-factor antagonist family
AMD06_RS15110	COG0326	Molecular chaperone. Has ATPase activity
AMD06_RS15115	COG2207	Transcriptional regulator
AMD06_RS15125	COG3152	Membrane
AMD06_RS15140	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AMD06_RS15145	COG1845	cytochrome c oxidase, subunit III
AMD06_RS15150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMD06_RS15165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMD06_RS15170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMD06_RS15175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMD06_RS15180	COG0196	riboflavin kinase activity
AMD06_RS15190	COG0268	Binds directly to 16S ribosomal RNA
AMD06_RS15195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMD06_RS15200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMD06_RS15205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMD06_RS15210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMD06_RS15215	COG0824	Thioesterase
AMD06_RS15230	COG1946	Acyl-CoA thioesterase
AMD06_RS15250	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AMD06_RS15260	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AMD06_RS15285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AMD06_RS15300	COG2197	response regulator
AMD06_RS15305	COG4585	Histidine kinase
AMD06_RS15320	COG0850	regulation of cytokinetic process
AMD06_RS15325	COG2894	cell division
AMD06_RS15330	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AMD06_RS15340	COG0642	Histidine kinase
AMD06_RS15345	COG0745	RESPONSE REGULATOR receiver
AMD06_RS15360	COG2194	sulfuric ester hydrolase activity
AMD06_RS15375	COG2814	Major facilitator Superfamily
AMD06_RS15380	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMD06_RS15380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMD06_RS15390	COG0656	L-ascorbic acid biosynthetic process
AMD06_RS15395	COG0753	catalase activity
AMD06_RS15425	COG2198	Histidine kinase
AMD06_RS15425	COG0643	Histidine kinase
AMD06_RS15430	COG0840	transmembrane signaling receptor activity
AMD06_RS15435	COG0835	chemotaxis
AMD06_RS15440	COG2199	diguanylate cyclase activity
AMD06_RS15440	COG2202	Pas domain
AMD06_RS15440	COG2200	EAL domain
AMD06_RS15445	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AMD06_RS15450	COG2201	protein-glutamate methylesterase activity
AMD06_RS15455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD06_RS15460	COG3590	peptidase
AMD06_RS15470	COG0588	phosphoglycerate mutase activity
AMD06_RS15475	COG1515	deoxyribonuclease V activity
AMD06_RS15485	COG1741	Belongs to the pirin family
AMD06_RS15500	COG1741	Belongs to the pirin family
AMD06_RS15505	COG1966	Carbon starvation protein
AMD06_RS15510	COG2879	small protein
AMD06_RS15555	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AMD06_RS15560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMD06_RS15565	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMD06_RS15570	COG2080	2 iron, 2 sulfur cluster binding
AMD06_RS15580	COG4251	negative regulation of phosphorylation
AMD06_RS15580	COG3706	GGDEF domain
AMD06_RS15580	COG2203	Gaf domain
AMD06_RS15580	COG5001	Diguanylate cyclase
AMD06_RS15585	COG0629	single-stranded DNA binding
AMD06_RS15590	COG0142	geranyltranstransferase activity
AMD06_RS15600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMD06_RS15615	COG0527	aspartate kinase activity
AMD06_RS15620	COG0384	phenazine biosynthesis protein PhzF
AMD06_RS15625	COG0384	phenazine biosynthesis protein PhzF
AMD06_RS15635	COG1764	response to oxidative stress
AMD06_RS15640	COG0540	Belongs to the ATCase OTCase family
AMD06_RS15645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AMD06_RS15650	COG1678	Uncharacterized ACR, COG1678
AMD06_RS15660	COG0519	Catalyzes the synthesis of GMP from XMP
AMD06_RS15670	COG5297	Belongs to the glycosyl hydrolase family 6
AMD06_RS15685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AMD06_RS15700	COG0739	heme binding
AMD06_RS15720	COG0693	protein deglycase activity
AMD06_RS15730	COG1959	2 iron, 2 sulfur cluster binding
AMD06_RS15735	COG0719	Fe-S assembly protein
AMD06_RS15740	COG0396	ATPase activity
AMD06_RS15745	COG0719	Fe-S assembly protein
AMD06_RS15750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMD06_RS15760	COG2146	nitrite reductase [NAD(P)H] activity
AMD06_RS15765	COG4774	siderophore transport
AMD06_RS15770	COG3128	pkhd-type hydroxylase
AMD06_RS15795	COG1477	protein flavinylation
AMD06_RS15800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AMD06_RS15815	COG1555	photosystem II stabilization
AMD06_RS15820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMD06_RS15830	COG3178	'Phosphotransferase
AMD06_RS15835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMD06_RS15845	COG0628	permease
AMD06_RS15855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMD06_RS15865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AMD06_RS15885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMD06_RS15890	COG0271	Belongs to the BolA IbaG family
AMD06_RS15900	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AMD06_RS15910	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AMD06_RS15915	COG1137	ATPase activity
AMD06_RS15930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD06_RS15935	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AMD06_RS15940	COG1660	Displays ATPase and GTPase activities
AMD06_RS15950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD06_RS15955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMD06_RS15960	COG2239	Acts as a magnesium transporter
AMD06_RS15970	COG1294	oxidase, subunit
AMD06_RS15975	COG1271	oxidase subunit
AMD06_RS15985	COG1113	amino acid transport
AMD06_RS16010	COG2197	response regulator
AMD06_RS16015	COG0531	amino acid
AMD06_RS16035	COG1234	tRNA 3'-trailer cleavage
AMD06_RS16070	COG2814	Major facilitator Superfamily
AMD06_RS16080	COG0754	glutathionylspermidine amidase activity
AMD06_RS16105	COG1842	Phage shock protein A
AMD06_RS16115	COG0259	pyridoxamine-phosphate oxidase activity
AMD06_RS16120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMD06_RS16125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AMD06_RS16135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AMD06_RS16210	COG0477	Major facilitator Superfamily
AMD06_RS16230	COG2198	Histidine kinase
AMD06_RS16230	COG2205	protein histidine kinase activity
AMD06_RS16230	COG0784	Response regulator, receiver
AMD06_RS16235	COG2353	YceI-like domain
AMD06_RS16255	COG1760	l-serine dehydratase
AMD06_RS16265	COG0460	homoserine dehydrogenase
AMD06_RS16265	COG0527	aspartate kinase activity
AMD06_RS16270	COG0626	cystathionine gamma-synthase activity
AMD06_RS16275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD06_RS16280	COG0739	heme binding
AMD06_RS16285	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AMD06_RS16290	COG1272	protein, Hemolysin III
AMD06_RS16295	COG2982	Protein involved in outer membrane biogenesis
AMD06_RS16300	COG0516	GMP reductase activity
AMD06_RS16300	COG0517	IMP dehydrogenase activity
AMD06_RS16305	COG0463	Glycosyl transferase, family 2
AMD06_RS16310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMD06_RS16315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AMD06_RS16325	COG4771	TonB-dependent receptor
AMD06_RS16335	COG1309	transcriptional regulator
AMD06_RS16345	COG1960	acyl-CoA dehydrogenase activity
AMD06_RS16370	COG0509	glycine decarboxylation via glycine cleavage system
AMD06_RS16375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMD06_RS16385	COG0330	HflC and HflK could
AMD06_RS16390	COG1742	UPF0060 membrane protein
AMD06_RS16395	COG3956	TIGRFAM MazG family protein
AMD06_RS16405	COG0494	nUDIX hydrolase
AMD06_RS16415	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AMD06_RS16420	COG0837	glucose binding
AMD06_RS16435	COG3858	chitin binding
AMD06_RS16435	COG1388	LysM domain
AMD06_RS16440	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AMD06_RS16450	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD06_RS16465	COG0531	amino acid
AMD06_RS16475	COG1486	melibiose metabolic process
AMD06_RS16485	COG3537	Alpha-1,2-mannosidase
AMD06_RS16520	COG3142	Participates in the control of copper homeostasis
AMD06_RS16525	COG1446	asparaginase
AMD06_RS16550	COG0643	Histidine kinase
AMD06_RS16550	COG2198	Histidine kinase
AMD06_RS16550	COG0784	Response regulator, receiver
AMD06_RS16555	COG0840	transmembrane signaling receptor activity
AMD06_RS16560	COG0835	chemotaxis
AMD06_RS16575	COG0189	ligase activity
AMD06_RS16585	COG1397	ADP-ribosylglycohydrolase
AMD06_RS16595	COG1199	ATP-dependent helicase activity
AMD06_RS16605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMD06_RS16610	COG1215	transferase activity, transferring glycosyl groups
AMD06_RS16620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD06_RS16625	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMD06_RS16630	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AMD06_RS16635	COG0535	radical SAM domain protein
AMD06_RS16640	COG0535	radical SAM domain protein
AMD06_RS16655	COG0837	glucose binding
AMD06_RS16665	COG1643	Atp-dependent helicase
AMD06_RS16670	COG0783	Belongs to the Dps family
AMD06_RS16675	COG0514	ATP-dependent DNA helicase (RecQ)
AMD06_RS16710	COG0840	transmembrane signaling receptor activity
AMD06_RS16730	COG3920	Histidine kinase
AMD06_RS16735	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AMD06_RS16745	COG0602	queuosine metabolic process
AMD06_RS16755	COG2885	chlorophyll binding
AMD06_RS16760	COG0823	Involved in the tonB-independent uptake of proteins
AMD06_RS16770	COG0848	biopolymer transport protein
AMD06_RS16780	COG0824	Thioesterase
AMD06_RS16785	COG2255	four-way junction helicase activity
AMD06_RS16795	COG3158	transport of potassium into the cell
AMD06_RS16800	COG0632	four-way junction helicase activity
AMD06_RS16805	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMD06_RS16810	COG0217	transcriptional regulatory protein
AMD06_RS16825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMD06_RS16840	COG0477	Major facilitator Superfamily
AMD06_RS16875	COG0488	(ABC) transporter
AMD06_RS16910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMD06_RS16910	COG4651	solute:proton antiporter activity
AMD06_RS16935	COG4772	TonB-dependent receptor
AMD06_RS16945	COG4264	IucA IucC family
AMD06_RS16960	COG0019	diaminopimelate decarboxylase activity
AMD06_RS16985	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AMD06_RS16995	COG1492	cobalamin metabolic process
AMD06_RS17005	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMD06_RS17025	COG4206	TonB-dependent receptor
AMD06_RS17030	COG0542	response to heat
AMD06_RS17035	COG1116	anion transmembrane transporter activity
AMD06_RS17040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD06_RS17045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMD06_RS17050	COG0667	Aldo Keto reductase
AMD06_RS17055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD06_RS17060	COG4771	TonB-dependent receptor
AMD06_RS17065	COG2827	Endonuclease containing a URI domain
AMD06_RS17105	COG1877	trehalose-phosphatase activity
AMD06_RS17110	COG3387	PFAM Glycoside hydrolase 15-related
AMD06_RS17125	COG0840	transmembrane signaling receptor activity
AMD06_RS17130	COG3011	Protein conserved in bacteria
AMD06_RS17145	COG0564	pseudouridine synthase activity
AMD06_RS17150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD06_RS17160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AMD06_RS17160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD06_RS17170	COG2963	transposase activity
AMD06_RS17190	COG2951	lytic endotransglycosylase activity
AMD06_RS17195	COG4644	lycopene metabolic process
AMD06_RS17255	COG2963	transposase activity
AMD06_RS17260	COG2801	Transposase and inactivated derivatives
AMD06_RS17290	COG0473	3-isopropylmalate dehydrogenase activity
AMD06_RS17305	COG4783	chaperone-mediated protein folding
AMD06_RS17320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AMD06_RS17330	COG0438	transferase activity, transferring glycosyl groups
AMD06_RS17335	COG0671	phosphoesterase, PA-phosphatase related
AMD06_RS17340	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD06_RS17350	COG3291	Pkd domain containing protein
AMD06_RS17380	COG0285	dihydrofolate synthase activity
AMD06_RS17385	COG0406	alpha-ribazole phosphatase activity
AMD06_RS17410	COG1063	alcohol dehydrogenase
AMD06_RS17420	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AMD06_RS17425	COG4208	sulfate ABC transporter
AMD06_RS17430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AMD06_RS17435	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AMD06_RS17440	COG0156	8-amino-7-oxononanoate synthase activity
AMD06_RS17470	COG0604	alcohol dehydrogenase
AMD06_RS17475	COG1902	pentaerythritol trinitrate reductase activity
AMD06_RS17475	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMD06_RS17485	COG0625	glutathione transferase activity
AMD06_RS17490	COG0039	L-malate dehydrogenase activity
AMD06_RS17495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMD06_RS17500	COG1217	gtp-binding protein TYPA
AMD06_RS17510	COG0154	amidase activity
AMD06_RS17520	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AMD06_RS17535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AMD06_RS17540	COG0203	ribosomal protein L17
AMD06_RS17565	COG0201	protein transport
AMD06_RS17570	COG0200	Binds to the 23S rRNA
AMD06_RS17575	COG1841	ribosomal large subunit assembly
AMD06_RS17585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AMD06_RS17590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMD06_RS17595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMD06_RS17605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMD06_RS17610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AMD06_RS17620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMD06_RS17625	COG0255	Belongs to the universal ribosomal protein uL29 family
AMD06_RS17630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AMD06_RS17635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMD06_RS17645	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMD06_RS17650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMD06_RS17655	COG0089	rRNA binding
AMD06_RS17660	COG0088	Forms part of the polypeptide exit tunnel
AMD06_RS17665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMD06_RS17670	COG0051	transcription antitermination factor activity, RNA binding
AMD06_RS17675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMD06_RS17680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMD06_RS17685	COG0049	tRNA binding
AMD06_RS17690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMD06_RS17695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMD06_RS17700	COG0085	RNA polymerase activity
AMD06_RS17705	COG0222	ribosome binding
AMD06_RS17710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMD06_RS17715	COG0081	regulation of translation
AMD06_RS17720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMD06_RS17725	COG0250	Participates in transcription elongation, termination and antitermination
AMD06_RS17740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMD06_RS17760	COG0012	GTP binding
AMD06_RS17765	COG0193	aminoacyl-tRNA hydrolase activity
AMD06_RS17770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AMD06_RS17775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AMD06_RS17785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AMD06_RS17790	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AMD06_RS17800	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AMD06_RS17805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMD06_RS17815	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMD06_RS17830	COG1254	Belongs to the acylphosphatase family
AMD06_RS17835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD06_RS17840	COG1295	ribonuclease BN
AMD06_RS17865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMD06_RS17870	COG1404	Belongs to the peptidase S8 family
AMD06_RS17875	COG1404	Belongs to the peptidase S8 family
AMD06_RS17880	COG1404	Belongs to the peptidase S8 family
AMD06_RS17885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMD06_RS17900	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AMD06_RS17925	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AMD06_RS17955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD06_RS17955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD06_RS17975	COG2890	protein-(glutamine-N5) methyltransferase activity
AMD06_RS17985	COG3634	alkyl hydroperoxide reductase activity
AMD06_RS17990	COG0583	DNA-binding transcription factor activity
AMD06_RS17995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD06_RS18000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMD06_RS18010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMD06_RS18020	COG2197	response regulator
AMD06_RS18025	COG0784	Response regulator, receiver
AMD06_RS18025	COG2205	protein histidine kinase activity
AMD06_RS18025	COG5002	protein histidine kinase activity
AMD06_RS18045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD06_RS18055	COG0697	spore germination
AMD06_RS18080	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AMD06_RS18090	COG3386	PFAM SMP-30 Gluconolaconase
AMD06_RS18110	COG1024	Enoyl-CoA hydratase
AMD06_RS18125	COG0583	DNA-binding transcription factor activity
AMD06_RS18130	COG3384	dioxygenase
AMD06_RS18160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD06_RS18165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD06_RS18175	COG2096	Adenosyltransferase
AMD06_RS18180	COG0123	including yeast histone deacetylase and acetoin utilization protein
AMD06_RS18190	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AMD06_RS18195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD06_RS18200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AMD06_RS18205	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMD06_RS18210	COG2967	ApaG domain
AMD06_RS18215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AMD06_RS18225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMD06_RS18235	COG0747	negative chemotaxis
AMD06_RS18260	COG0431	NADPH-dependent FMN reductase
AMD06_RS18265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD06_RS18275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD06_RS18280	COG1116	anion transmembrane transporter activity
AMD06_RS18290	COG3829	transcription factor binding
AMD06_RS18305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AMD06_RS18310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMD06_RS18330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AMD06_RS18340	COG0642	Histidine kinase
AMD06_RS18355	COG4181	ATPase activity
AMD06_RS18365	COG2175	clavaminate synthase activity
AMD06_RS18375	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AMD06_RS18380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD06_RS18400	COG4771	TonB-dependent receptor
AMD06_RS18410	COG0667	Aldo Keto reductase
AMD06_RS18415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AMD06_RS18420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD06_RS18430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMD06_RS18435	COG4106	trans-aconitate 2-methyltransferase activity
AMD06_RS18445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMD06_RS18480	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AMD06_RS18490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AMD06_RS18495	COG2226	methyltransferase
AMD06_RS18525	COG0366	Alpha amylase catalytic
AMD06_RS18545	COG0604	alcohol dehydrogenase
AMD06_RS18545	COG3321	synthase
AMD06_RS18545	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS18565	COG0494	nUDIX hydrolase
AMD06_RS18570	COG0653	protein targeting
AMD06_RS18575	COG0739	heme binding
AMD06_RS18585	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AMD06_RS18600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AMD06_RS18605	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMD06_RS18610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMD06_RS18615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMD06_RS18620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMD06_RS18630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMD06_RS18635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMD06_RS18640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMD06_RS18650	COG3116	cell division
AMD06_RS18655	COG0275	rRNA processing
AMD06_RS18685	COG0792	nuclease activity
AMD06_RS18690	COG1988	membrane-bound metal-dependent
AMD06_RS18695	COG0277	FAD linked oxidase domain protein
AMD06_RS18710	COG0745	RESPONSE REGULATOR receiver
AMD06_RS18715	COG2205	protein histidine kinase activity
AMD06_RS18720	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AMD06_RS18725	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AMD06_RS18730	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AMD06_RS18750	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AMD06_RS18755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMD06_RS18760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMD06_RS18780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMD06_RS18780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMD06_RS18790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMD06_RS18795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMD06_RS18805	COG0488	(ABC) transporter
AMD06_RS18815	COG0697	spore germination
AMD06_RS18825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMD06_RS18840	COG3791	Glutathione-dependent formaldehyde-activating
AMD06_RS18870	COG2205	protein histidine kinase activity
AMD06_RS18885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AMD06_RS18890	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AMD06_RS18905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMD06_RS18915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AMD06_RS18920	COG1012	belongs to the aldehyde dehydrogenase family
AMD06_RS18925	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AMD06_RS18930	COG0617	tRNA 3'-terminal CCA addition
AMD06_RS18940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AMD06_RS18945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMD06_RS18950	COG1609	Transcriptional regulator
AMD06_RS18960	COG2188	Transcriptional regulator
AMD06_RS18975	COG3250	beta-galactosidase activity
AMD06_RS19025	COG1459	type II secretion system
AMD06_RS19080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AMD06_RS19085	COG4191	Histidine kinase
AMD06_RS19090	COG0784	Response regulator, receiver
AMD06_RS19095	COG4251	negative regulation of phosphorylation
AMD06_RS19100	COG2823	Periplasmic or secreted lipoprotein
AMD06_RS19105	COG0673	inositol 2-dehydrogenase activity
AMD06_RS19110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AMD06_RS19145	COG1056	cytidyltransferase-related domain
AMD06_RS19145	COG1051	belongs to the nudix hydrolase family
AMD06_RS19155	COG0583	DNA-binding transcription factor activity
AMD06_RS19170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMD06_RS19175	COG0321	lipoyl(octanoyl) transferase activity
AMD06_RS19180	COG2921	Belongs to the UPF0250 family
AMD06_RS19190	COG1686	Belongs to the peptidase S11 family
AMD06_RS19200	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AMD06_RS19205	COG2951	lytic endotransglycosylase activity
AMD06_RS19215	COG0772	Belongs to the SEDS family
AMD06_RS19230	COG1792	Involved in formation and maintenance of cell shape
AMD06_RS19235	COG1077	Cell shape determining protein MreB Mrl
AMD06_RS19240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD06_RS19245	COG3284	Transcriptional regulator
AMD06_RS19295	COG0308	aminopeptidase N
AMD06_RS19300	COG3300	MHYT domain
AMD06_RS19300	COG5001	Diguanylate cyclase
AMD06_RS19305	COG2226	methyltransferase
AMD06_RS19330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AMD06_RS19335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AMD06_RS19340	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AMD06_RS19350	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AMD06_RS19360	COG2832	Protein of unknown function (DUF454)
AMD06_RS19370	COG0436	Aminotransferase
AMD06_RS19375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMD06_RS19380	COG1505	serine-type exopeptidase activity
AMD06_RS19405	COG0181	hydroxymethylbilane synthase activity
AMD06_RS19415	COG3275	phosphorelay sensor kinase activity
AMD06_RS19425	COG2943	transferase activity, transferring hexosyl groups
AMD06_RS19455	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD06_RS19455	COG5297	Belongs to the glycosyl hydrolase family 6
AMD06_RS19460	COG0840	transmembrane signaling receptor activity
AMD06_RS19465	COG5001	Diguanylate cyclase
AMD06_RS19505	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AMD06_RS19525	COG1113	amino acid transport
AMD06_RS19550	COG0697	spore germination
AMD06_RS19590	COG1506	peptidase
AMD06_RS19590	COG0823	Involved in the tonB-independent uptake of proteins
AMD06_RS19595	COG2409	Drug exporters of the RND superfamily
AMD06_RS19620	COG0435	Glutathione S-transferase
AMD06_RS19645	COG2003	Belongs to the UPF0758 family
AMD06_RS19670	COG0784	Response regulator, receiver
AMD06_RS19670	COG4191	Histidine kinase
AMD06_RS19705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD06_RS19715	COG2895	sulfate adenylyltransferase (ATP) activity
AMD06_RS19715	COG0529	Catalyzes the synthesis of activated sulfate
AMD06_RS19720	COG0175	sulfate reduction
AMD06_RS19725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AMD06_RS19730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMD06_RS19735	COG0175	sulfate reduction
AMD06_RS19755	COG2198	Histidine kinase
AMD06_RS19755	COG0784	Response regulator, receiver
AMD06_RS19755	COG2205	protein histidine kinase activity
AMD06_RS19790	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AMD06_RS19795	COG3588	fructose-bisphosphate aldolase
AMD06_RS19800	COG0469	pyruvate kinase activity
AMD06_RS19810	COG0126	phosphoglycerate kinase activity
AMD06_RS19830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AMD06_RS19840	COG3047	cAMP biosynthetic process
AMD06_RS19845	COG3047	cAMP biosynthetic process
AMD06_RS19855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD06_RS19855	COG3453	Protein conserved in bacteria
AMD06_RS19860	COG0725	ABC transporter, periplasmic molybdate-binding protein
AMD06_RS19865	COG4149	molybdate abc transporter
AMD06_RS19870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AMD06_RS19905	COG1376	ErfK ybiS ycfS ynhG family protein
AMD06_RS19910	COG0739	heme binding
AMD06_RS19920	COG4773	Receptor
AMD06_RS19940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AMD06_RS19945	COG1301	dicarboxylic acid transport
AMD06_RS19955	COG2304	oxidoreductase activity
AMD06_RS19975	COG0714	Associated with various cellular activities
AMD06_RS20005	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AMD06_RS20030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AMD06_RS20040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD06_RS20050	COG0194	GDP metabolic process
AMD06_RS20055	COG1561	YicC-like family, N-terminal region
AMD06_RS20060	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMD06_RS20070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMD06_RS20075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMD06_RS20090	COG0006	proline dipeptidase activity
AMD06_RS20100	COG0006	proline dipeptidase activity
AMD06_RS20105	COG3079	Belongs to the UPF0149 family
AMD06_RS20120	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMD06_RS20130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AMD06_RS20140	COG2912	Transglutaminase-like superfamily
AMD06_RS20145	COG1773	rubredoxin
AMD06_RS20150	COG0352	thiamine-phosphate diphosphorylase activity
AMD06_RS20165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMD06_RS20180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMD06_RS20210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMD06_RS20215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD06_RS20220	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS20230	COG0671	phosphoesterase, PA-phosphatase related
AMD06_RS20235	COG3781	membrane
AMD06_RS20245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMD06_RS20250	COG0563	adenylate kinase activity
AMD06_RS20265	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AMD06_RS20275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMD06_RS20295	COG3710	Transcriptional regulator
AMD06_RS20300	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMD06_RS20310	COG0840	transmembrane signaling receptor activity
AMD06_RS20315	COG0405	Gamma-glutamyltransferase
AMD06_RS20320	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMD06_RS20340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMD06_RS20345	COG0473	3-isopropylmalate dehydrogenase activity
AMD06_RS20350	COG0066	3-isopropylmalate dehydratase activity
AMD06_RS20355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMD06_RS20375	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMD06_RS20380	COG1538	Outer membrane efflux protein
AMD06_RS20385	COG1519	Transferase
AMD06_RS20390	COG1560	Kdo2-lipid A biosynthetic process
AMD06_RS20415	COG0281	malic enzyme
AMD06_RS20415	COG0280	phosphate acetyltransferase
AMD06_RS20420	COG1301	dicarboxylic acid transport
AMD06_RS20445	COG0583	DNA-binding transcription factor activity
AMD06_RS20450	COG0667	Aldo Keto reductase
AMD06_RS20465	COG2197	response regulator
AMD06_RS20475	COG0642	Histidine kinase
AMD06_RS20490	COG2851	Citrate transporter
AMD06_RS20495	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS20500	COG1609	Transcriptional regulator
AMD06_RS20505	COG2211	Major facilitator Superfamily
AMD06_RS20530	COG1162	GTPase activity
AMD06_RS20550	COG4773	Receptor
AMD06_RS20555	COG0726	polysaccharide deacetylase
AMD06_RS20560	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AMD06_RS20575	COG2963	transposase activity
AMD06_RS20580	COG2801	Transposase and inactivated derivatives
AMD06_RS20595	COG1307	EDD domain protein, DegV family
AMD06_RS20600	COG0242	peptide deformylase activity
AMD06_RS20625	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AMD06_RS20630	COG1215	transferase activity, transferring glycosyl groups
AMD06_RS20635	COG1215	transferase activity, transferring glycosyl groups
AMD06_RS20650	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AMD06_RS20705	COG2188	Transcriptional regulator
AMD06_RS20715	COG1450	Type ii and iii secretion system protein
AMD06_RS20730	COG3166	PFAM Fimbrial assembly family protein
AMD06_RS20735	COG3156	type II secretion system protein K
AMD06_RS20740	COG4795	General secretion pathway protein
AMD06_RS20745	COG2165	general secretion pathway protein
AMD06_RS20750	COG4970	Tfp pilus assembly protein FimT
AMD06_RS20755	COG2165	general secretion pathway protein
AMD06_RS20760	COG1459	type II secretion system
AMD06_RS20765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD06_RS20770	COG1404	Belongs to the peptidase S8 family
AMD06_RS20775	COG5295	Hep Hag repeat protein
AMD06_RS20780	COG1404	Belongs to the peptidase S8 family
AMD06_RS20785	COG5295	Hep Hag repeat protein
AMD06_RS20795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMD06_RS20795	COG0047	phosphoribosylformylglycinamidine synthase activity
AMD06_RS20800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMD06_RS20805	COG4974	Belongs to the 'phage' integrase family
AMD06_RS20820	COG0795	lipopolysaccharide-transporting ATPase activity
AMD06_RS20830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMD06_RS20845	COG0525	valine-tRNA ligase activity
AMD06_RS20875	COG1183	phosphatidylcholine synthase activity
AMD06_RS20885	COG0442	prolyl-tRNA aminoacylation
AMD06_RS20900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMD06_RS20905	COG1127	ABC transporter
AMD06_RS20910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMD06_RS20910	COG3218	ABC-type transport auxiliary lipoprotein component
AMD06_RS20945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD06_RS20950	COG0662	Cupin 2, conserved barrel domain protein
AMD06_RS20950	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AMD06_RS20980	COG2086	electron transfer activity
AMD06_RS20995	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMD06_RS20995	COG0546	phosphoglycolate phosphatase activity
AMD06_RS21000	COG0277	FAD linked oxidase domain protein
AMD06_RS21005	COG0300	oxidoreductase activity
AMD06_RS21015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD06_RS21035	COG2226	methyltransferase
AMD06_RS21045	COG3754	Rhamnan synthesis protein F
AMD06_RS21050	COG1216	Glycosyl transferase, family 2
AMD06_RS21050	COG0438	transferase activity, transferring glycosyl groups
AMD06_RS21055	COG0110	maltose O-acetyltransferase activity
AMD06_RS21070	COG0626	cystathionine gamma-synthase activity
AMD06_RS21100	COG0625	glutathione transferase activity
AMD06_RS21110	COG0513	Belongs to the DEAD box helicase family
AMD06_RS21120	COG4206	TonB-dependent receptor
AMD06_RS21125	COG0720	synthase
AMD06_RS21135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AMD06_RS21145	COG1956	GAF domain-containing protein
AMD06_RS21155	COG2819	hydrolase of the alpha beta superfamily
AMD06_RS21170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMD06_RS21175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD06_RS21190	COG0339	signal peptide processing
AMD06_RS21240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMD06_RS21245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD06_RS21250	COG1136	(ABC) transporter
AMD06_RS21250	COG4591	ABC-type transport system involved in lipoprotein release permease component
AMD06_RS21255	COG0577	efflux transmembrane transporter activity
AMD06_RS21260	COG0577	efflux transmembrane transporter activity
AMD06_RS21275	COG4191	Histidine kinase
AMD06_RS21280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMD06_RS21295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AMD06_RS21300	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AMD06_RS21305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AMD06_RS21310	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMD06_RS21315	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMD06_RS21320	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMD06_RS21330	COG0356	it plays a direct role in the translocation of protons across the membrane
AMD06_RS21350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMD06_RS21360	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMD06_RS21405	COG2011	ABC-type metal ion transport system permease component
AMD06_RS21410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMD06_RS21415	COG0697	spore germination
AMD06_RS21420	COG1666	GTP binding
AMD06_RS21430	COG5002	protein histidine kinase activity
AMD06_RS21430	COG0784	Response regulator, receiver
AMD06_RS21430	COG2198	Histidine kinase
AMD06_RS21455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMD06_RS21460	COG1187	pseudouridine synthase activity
AMD06_RS21465	COG2813	Specifically methylates the guanine in position
AMD06_RS21485	COG2202	Pas domain
AMD06_RS21485	COG2205	protein histidine kinase activity
AMD06_RS21505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMD06_RS21510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD06_RS21565	COG0842	Transport permease protein
AMD06_RS21570	COG1131	(ABC) transporter
AMD06_RS21575	COG0025	NhaP-type Na H and K H
AMD06_RS21580	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AMD06_RS21585	COG1573	uracil-dna glycosylase
AMD06_RS21595	COG3384	dioxygenase
AMD06_RS21605	COG0583	DNA-binding transcription factor activity
AMD06_RS21615	COG0667	Aldo Keto reductase
AMD06_RS21625	COG3590	peptidase
AMD06_RS21645	COG0531	amino acid
AMD06_RS21660	COG2972	Histidine kinase
AMD06_RS21675	COG3685	Protein conserved in bacteria
AMD06_RS21680	COG3546	catalase activity
AMD06_RS21725	COG1271	oxidase subunit
AMD06_RS21730	COG1294	oxidase, subunit
AMD06_RS21745	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS21750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMD06_RS21770	COG1132	(ABC) transporter
AMD06_RS21785	COG1063	alcohol dehydrogenase
AMD06_RS21860	COG0251	oxidation-reduction process
AMD06_RS21875	COG0840	transmembrane signaling receptor activity
AMD06_RS21895	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMD06_RS21935	COG0024	Methionine aminopeptidase
AMD06_RS21955	COG2963	transposase activity
AMD06_RS21960	COG2801	Transposase and inactivated derivatives
AMD06_RS21975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMD06_RS22005	COG4695	Portal protein
AMD06_RS22050	COG3179	chitinase
AMD06_RS22230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMD06_RS22235	COG1490	D-aminoacyl-tRNA deacylase activity
AMD06_RS22240	COG1560	Kdo2-lipid A biosynthetic process
AMD06_RS22290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AMD06_RS22290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMD06_RS22295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMD06_RS22300	COG0242	peptide deformylase activity
AMD06_RS22305	COG1652	LysM domain
AMD06_RS22310	COG0758	DNA mediated transformation
AMD06_RS22330	COG1754	DNA topoisomerase type I activity
AMD06_RS22330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMD06_RS22335	COG0009	L-threonylcarbamoyladenylate synthase
AMD06_RS22350	COG1028	Short-chain dehydrogenase reductase Sdr
AMD06_RS22360	COG0616	signal peptide processing
AMD06_RS22365	COG0534	Mate efflux family protein
AMD06_RS22385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AMD06_RS22390	COG0625	glutathione transferase activity
AMD06_RS22405	COG1252	NADH dehydrogenase
AMD06_RS22410	COG2860	membrane
AMD06_RS22415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMD06_RS22420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMD06_RS22425	COG2201	protein-glutamate methylesterase activity
AMD06_RS22430	COG2177	Part of the ABC transporter FtsEX involved in
AMD06_RS22435	COG2884	Cell division ATP-binding protein ftsE
AMD06_RS22440	COG0513	Belongs to the DEAD box helicase family
AMD06_RS22445	COG3118	belongs to the thioredoxin family
AMD06_RS22450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AMD06_RS22455	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AMD06_RS22460	COG0583	DNA-binding transcription factor activity
AMD06_RS22505	COG1518	maintenance of DNA repeat elements
AMD06_RS22530	COG1652	LysM domain
AMD06_RS22535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AMD06_RS22535	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AMD06_RS22540	COG1473	amidohydrolase
AMD06_RS22545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD06_RS22550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD06_RS22560	COG5383	Protein conserved in bacteria
AMD06_RS22600	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AMD06_RS22605	COG3023	N-Acetylmuramoyl-L-alanine amidase
AMD06_RS22615	COG4948	Mandelate Racemase Muconate Lactonizing
AMD06_RS22625	COG0531	amino acid
AMD06_RS22640	COG4682	membrane
AMD06_RS22645	COG2133	pyrroloquinoline quinone binding
AMD06_RS22655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AMD06_RS22660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMD06_RS22670	COG1610	YqeY-like protein
AMD06_RS22675	COG1295	ribonuclease BN
AMD06_RS22680	COG0358	DNA primase activity
AMD06_RS22695	COG0109	protoheme IX farnesyltransferase activity
AMD06_RS22725	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AMD06_RS22780	COG3135	benzoate transporter
AMD06_RS22800	COG0676	glucose-6-phosphate 1-epimerase activity
AMD06_RS22810	COG3012	SEC-C Motif Domain Protein
AMD06_RS22815	COG0730	response to heat
AMD06_RS22835	COG0302	gtp cyclohydrolase
AMD06_RS22850	COG1566	PFAM secretion protein HlyD family protein
AMD06_RS22860	COG1289	transmembrane transporter activity
AMD06_RS22865	COG0477	Major facilitator Superfamily
AMD06_RS22875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD06_RS22895	COG4691	Plasmid stability protein
AMD06_RS22900	COG1487	ribonuclease activity
AMD06_RS22925	COG0564	pseudouridine synthase activity
AMD06_RS22935	COG2963	transposase activity
AMD06_RS22960	COG0439	Biotin carboxylase
AMD06_RS23000	COG1074	ATP-dependent DNA helicase activity
AMD06_RS23005	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AMD06_RS23020	COG1127	ABC transporter
AMD06_RS23025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMD06_RS23030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMD06_RS23045	COG2853	Lipoprotein
AMD06_RS23055	COG0386	Belongs to the glutathione peroxidase family
AMD06_RS23065	COG1322	Protein conserved in bacteria
AMD06_RS23070	COG0604	alcohol dehydrogenase
AMD06_RS23085	COG0625	glutathione transferase activity
AMD06_RS23095	COG0531	amino acid
AMD06_RS23100	COG3537	Alpha-1,2-mannosidase
AMD06_RS23110	COG3706	GGDEF domain
AMD06_RS23115	COG3835	regulator
AMD06_RS23120	COG1929	Belongs to the glycerate kinase type-1 family
AMD06_RS23125	COG2271	Major facilitator Superfamily
AMD06_RS23140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AMD06_RS23145	COG0861	Integral membrane protein TerC family
AMD06_RS23155	COG0584	glycerophosphoryl diester phosphodiesterase
AMD06_RS23170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AMD06_RS23175	COG0726	polysaccharide deacetylase
AMD06_RS23185	COG0706	membrane insertase activity
AMD06_RS23190	COG0594	ribonuclease P activity