locus-tag	class	description
XCAW_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XCAW_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XCAW_RS00020	COG0187	DNA topoisomerase II activity
XCAW_RS00030	COG0501	Belongs to the peptidase M48B family
XCAW_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XCAW_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCAW_RS00115	COG0793	Belongs to the peptidase S41A family
XCAW_RS00120	COG4942	peptidase
XCAW_RS00130	COG2234	aminopeptidase activity
XCAW_RS00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCAW_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCAW_RS00180	COG2211	Major facilitator Superfamily
XCAW_RS00195	COG3693	PFAM glycoside hydrolase, family 10
XCAW_RS00210	COG3693	PFAM glycoside hydrolase, family 10
XCAW_RS00215	COG1904	glucuronate isomerase
XCAW_RS00220	COG3250	beta-galactosidase activity
XCAW_RS00230	COG3386	PFAM SMP-30 Gluconolaconase
XCAW_RS00255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XCAW_RS00300	COG0246	Mannitol dehydrogenase
XCAW_RS00305	COG1472	Belongs to the glycosyl hydrolase 3 family
XCAW_RS00315	COG4948	Mandelate Racemase Muconate Lactonizing
XCAW_RS00325	COG3661	Belongs to the glycosyl hydrolase 67 family
XCAW_RS00335	COG2115	Belongs to the xylose isomerase family
XCAW_RS00345	COG2974	May be involved in recombination
XCAW_RS00365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XCAW_RS00375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XCAW_RS00380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XCAW_RS00385	COG0805	protein transport
XCAW_RS00395	COG0519	Catalyzes the synthesis of GMP from XMP
XCAW_RS00395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XCAW_RS00405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XCAW_RS00410	COG0752	glycyl-tRNA synthetase alpha subunit
XCAW_RS00440	COG0729	surface antigen
XCAW_RS00445	COG2911	Protein conserved in bacteria
XCAW_RS00465	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCAW_RS00470	COG3265	gluconokinase activity
XCAW_RS00475	COG2211	Major facilitator Superfamily
XCAW_RS00480	COG3459	Glycosyltransferase 36 associated
XCAW_RS00495	COG2205	protein histidine kinase activity
XCAW_RS00500	COG1971	Probably functions as a manganese efflux pump
XCAW_RS00505	COG1414	Transcriptional regulator
XCAW_RS00510	COG0738	Major facilitator superfamily
XCAW_RS00515	COG3254	rhamnose metabolic process
XCAW_RS00525	COG4948	Mandelate Racemase Muconate Lactonizing
XCAW_RS00530	COG0179	Fumarylacetoacetate (FAA) hydrolase
XCAW_RS00535	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS00555	COG3507	Belongs to the glycosyl hydrolase 43 family
XCAW_RS00585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XCAW_RS00595	COG3162	membrane
XCAW_RS00600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XCAW_RS00610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XCAW_RS00620	COG1940	carbohydrate kinase activity
XCAW_RS00620	COG1846	Transcriptional regulator
XCAW_RS00625	COG0708	Exodeoxyribonuclease III
XCAW_RS00645	COG2091	lysine biosynthetic process via aminoadipic acid
XCAW_RS00655	COG3540	Alkaline phosphatase
XCAW_RS00660	COG0357	Ribosomal RNA small subunit methyltransferase G
XCAW_RS00680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCAW_RS00700	COG2159	amidohydrolase
XCAW_RS00710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XCAW_RS00715	COG0583	DNA-binding transcription factor activity
XCAW_RS00720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCAW_RS00735	COG0210	DNA helicase
XCAW_RS00895	COG0631	protein serine/threonine phosphatase activity
XCAW_RS00900	COG2815	serine threonine protein kinase
XCAW_RS00900	COG0515	serine threonine protein kinase
XCAW_RS00935	COG0408	coproporphyrinogen oxidase activity
XCAW_RS00950	COG1506	peptidase
XCAW_RS00950	COG0823	Involved in the tonB-independent uptake of proteins
XCAW_RS00950	COG4946	Tricorn protease homolog
XCAW_RS00975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XCAW_RS00990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XCAW_RS01025	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS01040	COG0463	Glycosyl transferase, family 2
XCAW_RS01050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XCAW_RS01055	COG3100	YcgL domain-containing protein
XCAW_RS01070	COG3387	PFAM Glycoside hydrolase 15-related
XCAW_RS01075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XCAW_RS01085	COG3338	carbonate dehydratase activity
XCAW_RS01090	COG2239	Acts as a magnesium transporter
XCAW_RS01095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XCAW_RS01095	COG1042	CoA-binding domain protein
XCAW_RS01095	COG0045	succinate-CoA ligase (ADP-forming) activity
XCAW_RS01105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XCAW_RS01110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XCAW_RS01140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XCAW_RS01150	COG0842	Transport permease protein
XCAW_RS01155	COG1131	(ABC) transporter
XCAW_RS01160	COG0543	2 iron, 2 sulfur cluster binding
XCAW_RS01160	COG0633	Ferredoxin
XCAW_RS01205	COG1476	TRANSCRIPTIONal
XCAW_RS01215	COG4555	ABC transporter
XCAW_RS01255	COG0625	glutathione transferase activity
XCAW_RS01315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XCAW_RS01330	COG1199	ATP-dependent helicase activity
XCAW_RS01355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XCAW_RS01400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XCAW_RS01415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XCAW_RS01455	COG3237	CsbD-like
XCAW_RS01460	COG0180	Tryptophanyl-tRNA synthetase
XCAW_RS01465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCAW_RS01480	COG0697	spore germination
XCAW_RS01505	COG1136	(ABC) transporter
XCAW_RS01510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCAW_RS01515	COG4585	Histidine kinase
XCAW_RS01520	COG2197	response regulator
XCAW_RS01535	COG0753	catalase activity
XCAW_RS01550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XCAW_RS01555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XCAW_RS01580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XCAW_RS01600	COG0642	Histidine kinase
XCAW_RS01610	COG1090	epimerase
XCAW_RS01650	COG1690	Belongs to the RtcB family
XCAW_RS01685	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XCAW_RS01700	COG0606	chelatase, subunit chli
XCAW_RS01740	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XCAW_RS01745	COG1166	arginine decarboxylase activity
XCAW_RS01755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XCAW_RS01765	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XCAW_RS01765	COG2755	lipolytic protein G-D-S-L family
XCAW_RS01770	COG4221	oxidoreductase activity
XCAW_RS01785	COG0018	arginyl-trna synthetase
XCAW_RS01790	COG2003	Belongs to the UPF0758 family
XCAW_RS01795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XCAW_RS01800	COG0756	dUTP diphosphatase activity
XCAW_RS01820	COG0463	Glycosyl transferase, family 2
XCAW_RS01835	COG1475	DNA binding
XCAW_RS01840	COG1192	Involved in chromosome partitioning
XCAW_RS01850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XCAW_RS01855	COG0708	Exodeoxyribonuclease III
XCAW_RS01860	COG2223	nitrite transmembrane transporter activity
XCAW_RS01870	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XCAW_RS01875	COG0739	heme binding
XCAW_RS01880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XCAW_RS01910	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XCAW_RS01920	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XCAW_RS01930	COG1435	thymidine kinase activity
XCAW_RS01935	COG0210	DNA helicase
XCAW_RS01955	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XCAW_RS01960	COG0284	orotidine-5'-phosphate decarboxylase activity
XCAW_RS01995	COG2937	Belongs to the GPAT DAPAT family
XCAW_RS02030	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCAW_RS02035	COG1064	alcohol dehydrogenase
XCAW_RS02040	COG0493	'glutamate synthase
XCAW_RS02045	COG0067	glutamate synthase
XCAW_RS02045	COG0069	glutamate synthase activity
XCAW_RS02045	COG0070	glutamate synthase
XCAW_RS02105	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XCAW_RS02110	COG0438	transferase activity, transferring glycosyl groups
XCAW_RS02110	COG0297	glycogen (starch) synthase activity
XCAW_RS02160	COG1132	(ABC) transporter
XCAW_RS02190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XCAW_RS02275	COG1205	dead DEAH box helicase
XCAW_RS02275	COG1111	helicase
XCAW_RS02280	COG1272	protein, Hemolysin III
XCAW_RS02295	COG0300	oxidoreductase activity
XCAW_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS02320	COG2249	NAD(P)H dehydrogenase (quinone) activity
XCAW_RS02325	COG2963	transposase activity
XCAW_RS02375	COG3237	CsbD-like
XCAW_RS02425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCAW_RS02435	COG0477	Major facilitator Superfamily
XCAW_RS02475	COG0714	Associated with various cellular activities
XCAW_RS02505	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XCAW_RS02515	COG4772	TonB-dependent receptor
XCAW_RS02525	COG0662	Cupin 2, conserved barrel domain protein
XCAW_RS02530	COG1012	belongs to the aldehyde dehydrogenase family
XCAW_RS02555	COG1304	FMN binding
XCAW_RS02570	COG4585	Histidine kinase
XCAW_RS02575	COG2197	response regulator
XCAW_RS02595	COG3710	Transcriptional regulator
XCAW_RS02600	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XCAW_RS02665	COG2963	transposase activity
XCAW_RS02670	COG2801	Transposase and inactivated derivatives
XCAW_RS02675	COG0366	Alpha amylase catalytic
XCAW_RS02680	COG0366	Alpha amylase catalytic
XCAW_RS02685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCAW_RS02705	COG2755	lipolytic protein G-D-S-L family
XCAW_RS02705	COG0657	acetylesterase activity
XCAW_RS02715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XCAW_RS02730	COG3507	Belongs to the glycosyl hydrolase 43 family
XCAW_RS02735	COG1609	Transcriptional regulator
XCAW_RS02740	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XCAW_RS02745	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS02755	COG2755	lipolytic protein G-D-S-L family
XCAW_RS02770	COG3186	Phenylalanine-4-hydroxylase
XCAW_RS02775	COG1522	sequence-specific DNA binding
XCAW_RS02785	COG1752	Esterase of the alpha-beta hydrolase superfamily
XCAW_RS02795	COG1119	ATPase activity
XCAW_RS02810	COG1125	glycine betaine transport
XCAW_RS02825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XCAW_RS02845	COG1396	sequence-specific DNA binding
XCAW_RS02870	COG0489	protein tyrosine kinase activity
XCAW_RS02875	COG2062	phosphohistidine phosphatase, SixA
XCAW_RS02885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCAW_RS02930	COG1968	undecaprenyl-diphosphatase activity
XCAW_RS02935	COG0174	glutamine synthetase
XCAW_RS02940	COG0347	Belongs to the P(II) protein family
XCAW_RS02945	COG0004	ammonium transporteR
XCAW_RS02950	COG3852	Histidine kinase
XCAW_RS02955	COG2204	response regulator
XCAW_RS02960	COG2032	superoxide dismutase activity
XCAW_RS02965	COG2032	superoxide dismutase activity
XCAW_RS02980	COG0183	Belongs to the thiolase family
XCAW_RS03015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XCAW_RS03020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XCAW_RS03025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XCAW_RS03035	COG0028	Belongs to the TPP enzyme family
XCAW_RS03040	COG2205	protein histidine kinase activity
XCAW_RS03065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XCAW_RS03080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCAW_RS03090	COG0596	Alpha beta hydrolase
XCAW_RS03095	COG0727	PFAM Uncharacterised protein family (UPF0153)
XCAW_RS03100	COG0318	PFAM AMP-dependent synthetase and ligase
XCAW_RS03105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCAW_RS03115	COG1181	Belongs to the D-alanine--D-alanine ligase family
XCAW_RS03125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XCAW_RS03135	COG0564	pseudouridine synthase activity
XCAW_RS03160	COG0339	signal peptide processing
XCAW_RS03190	COG0475	glutathione-regulated potassium exporter activity
XCAW_RS03195	COG0583	DNA-binding transcription factor activity
XCAW_RS03200	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XCAW_RS03235	COG4770	biotin carboxylase activity
XCAW_RS03240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XCAW_RS03245	COG1960	acyl-CoA dehydrogenase activity
XCAW_RS03300	COG0523	cobalamin synthesis protein
XCAW_RS03315	COG0697	spore germination
XCAW_RS03325	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XCAW_RS03330	COG1846	Transcriptional regulator
XCAW_RS03335	COG1764	response to oxidative stress
XCAW_RS03365	COG2130	NADP-dependent
XCAW_RS03380	COG1187	pseudouridine synthase activity
XCAW_RS03395	COG1643	Atp-dependent helicase
XCAW_RS03405	COG4807	Protein conserved in bacteria
XCAW_RS03410	COG2351	hydroxyisourate hydrolase activity
XCAW_RS03415	COG2072	flavoprotein involved in K transport
XCAW_RS03435	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XCAW_RS03470	COG1957	nucleoside hydrolase
XCAW_RS03480	COG2252	PERMEase
XCAW_RS03505	COG0084	hydrolase, TatD family'
XCAW_RS03520	COG0583	DNA-binding transcription factor activity
XCAW_RS03525	COG2814	Major facilitator Superfamily
XCAW_RS03535	COG2267	carboxylic ester hydrolase activity
XCAW_RS03540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XCAW_RS03545	COG1902	pentaerythritol trinitrate reductase activity
XCAW_RS03565	COG0745	RESPONSE REGULATOR receiver
XCAW_RS03570	COG2205	protein histidine kinase activity
XCAW_RS03575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCAW_RS03595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XCAW_RS03600	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XCAW_RS03605	COG0583	DNA-binding transcription factor activity
XCAW_RS03640	COG0702	epimerase
XCAW_RS03645	COG1733	regulation of RNA biosynthetic process
XCAW_RS03670	COG2801	Transposase and inactivated derivatives
XCAW_RS03675	COG2963	transposase activity
XCAW_RS03685	COG0129	dihydroxy-acid dehydratase activity
XCAW_RS03705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XCAW_RS03760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XCAW_RS03765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XCAW_RS03790	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XCAW_RS03795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XCAW_RS03805	COG3485	protocatechuate 3,4-dioxygenase
XCAW_RS03810	COG3485	protocatechuate 3,4-dioxygenase
XCAW_RS03820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCAW_RS03825	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XCAW_RS03835	COG1414	Transcriptional regulator
XCAW_RS03845	COG0657	acetylesterase activity
XCAW_RS03855	COG0445	tRNA wobble uridine modification
XCAW_RS03865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XCAW_RS03895	COG2267	carboxylic ester hydrolase activity
XCAW_RS03905	COG0156	8-amino-7-oxononanoate synthase activity
XCAW_RS03910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XCAW_RS03915	COG1040	competence protein
XCAW_RS03920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XCAW_RS03995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XCAW_RS04065	COG3264	Mechanosensitive ion channel
XCAW_RS04065	COG1511	domain protein
XCAW_RS04070	COG1368	sulfuric ester hydrolase activity
XCAW_RS04080	COG2354	Protein conserved in bacteria
XCAW_RS04090	COG0297	glycogen (starch) synthase activity
XCAW_RS04095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCAW_RS04100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCAW_RS04125	COG0702	epimerase
XCAW_RS04130	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS04165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCAW_RS04170	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS04180	COG0513	Belongs to the DEAD box helicase family
XCAW_RS04200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XCAW_RS04210	COG3483	tryptophan 2,3-dioxygenase activity
XCAW_RS04215	COG3104	oligopeptide transport
XCAW_RS04235	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XCAW_RS04250	COG1320	monovalent cation:proton antiporter activity
XCAW_RS04255	COG2212	antiporter activity
XCAW_RS04265	COG0651	ATP synthesis coupled electron transport
XCAW_RS04270	COG1006	Multisubunit Na H antiporter MnhC subunit
XCAW_RS04275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XCAW_RS04275	COG2111	Na H antiporter
XCAW_RS04295	COG3179	chitinase
XCAW_RS04315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XCAW_RS04320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XCAW_RS04335	COG0456	acetyltransferase
XCAW_RS04340	COG1597	lipid kinase activity
XCAW_RS04365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XCAW_RS04370	COG0134	indole-3-glycerol-phosphate synthase activity
XCAW_RS04380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XCAW_RS04385	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XCAW_RS04395	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XCAW_RS04405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XCAW_RS04420	COG1051	belongs to the nudix hydrolase family
XCAW_RS04460	COG0316	Belongs to the HesB IscA family
XCAW_RS04480	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XCAW_RS04500	COG2814	Major facilitator Superfamily
XCAW_RS04505	COG0583	DNA-binding transcription factor activity
XCAW_RS04510	COG2814	Major facilitator Superfamily
XCAW_RS04515	COG1289	transmembrane transporter activity
XCAW_RS04525	COG0151	Belongs to the GarS family
XCAW_RS04535	COG0138	bifunctional purine biosynthesis protein purh
XCAW_RS04540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XCAW_RS04545	COG2267	carboxylic ester hydrolase activity
XCAW_RS04550	COG2453	phosphatase
XCAW_RS04550	COG0671	phosphoesterase, PA-phosphatase related
XCAW_RS04575	COG4589	Belongs to the CDS family
XCAW_RS04580	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XCAW_RS04605	COG2264	protein methyltransferase activity
XCAW_RS04625	COG0439	Biotin carboxylase
XCAW_RS04635	COG0511	ligase activity, forming carbon-carbon bonds
XCAW_RS04640	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XCAW_RS04650	COG1324	tolerance protein
XCAW_RS04675	COG0300	oxidoreductase activity
XCAW_RS04680	COG2356	endonuclease I
XCAW_RS04690	COG0459	protein refolding
XCAW_RS04705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XCAW_RS04720	COG3386	PFAM SMP-30 Gluconolaconase
XCAW_RS04730	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XCAW_RS04735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XCAW_RS04755	COG0778	Nitroreductase
XCAW_RS04760	COG2353	YceI-like domain
XCAW_RS04790	COG3052	prosthetic group binding
XCAW_RS04815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XCAW_RS04825	COG1802	Transcriptional regulator
XCAW_RS04880	COG2963	transposase activity
XCAW_RS04885	COG4221	oxidoreductase activity
XCAW_RS04900	COG4221	oxidoreductase activity
XCAW_RS04910	COG0435	Glutathione S-transferase
XCAW_RS04940	COG2963	transposase activity
XCAW_RS04960	COG0308	aminopeptidase N
XCAW_RS04970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XCAW_RS04985	COG4948	Mandelate Racemase Muconate Lactonizing
XCAW_RS04990	COG3250	beta-galactosidase activity
XCAW_RS05015	COG1970	mechanosensitive ion channel activity
XCAW_RS05035	COG3273	potassium ion transport
XCAW_RS05035	COG0471	metal ion transport
XCAW_RS05040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XCAW_RS05045	COG2022	thiamine diphosphate biosynthetic process
XCAW_RS05150	COG2003	Belongs to the UPF0758 family
XCAW_RS05190	COG2189	Belongs to the N(4) N(6)-methyltransferase family
XCAW_RS05290	COG0745	RESPONSE REGULATOR receiver
XCAW_RS05295	COG5002	protein histidine kinase activity
XCAW_RS05300	COG2801	Transposase and inactivated derivatives
XCAW_RS05305	COG2963	transposase activity
XCAW_RS05320	COG0237	dephospho-CoA kinase activity
XCAW_RS05325	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XCAW_RS05355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XCAW_RS05370	COG0045	succinate-CoA ligase (ADP-forming) activity
XCAW_RS05375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XCAW_RS05400	COG2369	cell adhesion
XCAW_RS05450	COG2963	transposase activity
XCAW_RS05455	COG2801	Transposase and inactivated derivatives
XCAW_RS05625	COG0784	Response regulator, receiver
XCAW_RS05625	COG4191	Histidine kinase
XCAW_RS05690	COG4695	Portal protein
XCAW_RS05710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XCAW_RS05720	COG3852	Histidine kinase
XCAW_RS05730	COG0544	peptidyl-prolyl cis-trans isomerase activity
XCAW_RS05740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XCAW_RS05770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XCAW_RS05780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCAW_RS05790	COG0328	RNA-DNA hybrid ribonuclease activity
XCAW_RS05795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XCAW_RS05800	COG0631	protein serine/threonine phosphatase activity
XCAW_RS05815	COG0859	PFAM glycosyl transferase family 9
XCAW_RS05820	COG3642	lipopolysaccharide core region biosynthetic process
XCAW_RS05825	COG1234	tRNA 3'-trailer cleavage
XCAW_RS05830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XCAW_RS05840	COG0315	cyclic pyranopterin monophosphate synthase activity
XCAW_RS05845	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XCAW_RS05850	COG0314	molybdopterin synthase activity
XCAW_RS05860	COG2963	transposase activity
XCAW_RS05865	COG2801	Transposase and inactivated derivatives
XCAW_RS05900	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XCAW_RS05905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XCAW_RS05910	COG0537	adenosine 5'-monophosphoramidase activity
XCAW_RS05930	COG0714	Associated with various cellular activities
XCAW_RS05955	COG0424	maF-like protein
XCAW_RS05960	COG1399	metal-binding, possibly nucleic acid-binding protein
XCAW_RS05965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XCAW_RS05970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCAW_RS05985	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS06000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XCAW_RS06005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XCAW_RS06030	COG3829	transcription factor binding
XCAW_RS06050	COG3609	addiction module antidote protein, CC2985 family
XCAW_RS06070	COG2373	Large extracellular alpha-helical protein
XCAW_RS06085	COG4953	penicillin-binding protein 1C
XCAW_RS06095	COG0678	peroxiredoxin activity
XCAW_RS06115	COG0330	HflC and HflK could
XCAW_RS06120	COG0330	HflC and HflK could
XCAW_RS06130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XCAW_RS06135	COG0308	aminopeptidase N
XCAW_RS06145	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS06150	COG1309	transcriptional regulator
XCAW_RS06225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XCAW_RS06235	COG3387	PFAM Glycoside hydrolase 15-related
XCAW_RS06240	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS06245	COG3537	Alpha-1,2-mannosidase
XCAW_RS06265	COG0492	ferredoxin-NADP+ reductase activity
XCAW_RS06290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XCAW_RS06295	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XCAW_RS06300	COG2080	2 iron, 2 sulfur cluster binding
XCAW_RS06335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XCAW_RS06350	COG0587	DNA-directed DNA polymerase activity
XCAW_RS06365	COG1297	OPT oligopeptide transporter protein
XCAW_RS06380	COG1506	peptidase
XCAW_RS06380	COG0823	Involved in the tonB-independent uptake of proteins
XCAW_RS06395	COG2207	Transcriptional regulator
XCAW_RS06395	COG1917	Cupin 2, conserved barrel domain protein
XCAW_RS06420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XCAW_RS06430	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XCAW_RS06435	COG0745	RESPONSE REGULATOR receiver
XCAW_RS06440	COG2205	protein histidine kinase activity
XCAW_RS06450	COG4452	Inner membrane protein CreD
XCAW_RS06475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCAW_RS06480	COG0735	belongs to the Fur family
XCAW_RS06495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCAW_RS06505	COG1309	transcriptional regulator
XCAW_RS06515	COG2207	Transcriptional regulator
XCAW_RS06525	COG0583	DNA-binding transcription factor activity
XCAW_RS06530	COG2814	Major facilitator Superfamily
XCAW_RS06535	COG0667	Aldo Keto reductase
XCAW_RS06650	COG5001	Diguanylate cyclase
XCAW_RS06650	COG5002	protein histidine kinase activity
XCAW_RS06655	COG1187	pseudouridine synthase activity
XCAW_RS06680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XCAW_RS06690	COG0475	glutathione-regulated potassium exporter activity
XCAW_RS06695	COG5002	protein histidine kinase activity
XCAW_RS06695	COG5000	phosphorelay sensor kinase activity
XCAW_RS06700	COG0745	RESPONSE REGULATOR receiver
XCAW_RS06705	COG1538	Outer membrane efflux protein
XCAW_RS06730	COG1132	(ABC) transporter
XCAW_RS06775	COG2155	Conserved Protein
XCAW_RS06800	COG3118	belongs to the thioredoxin family
XCAW_RS06810	COG0495	leucyl-tRNA aminoacylation
XCAW_RS06825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XCAW_RS06840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XCAW_RS06855	COG2968	Membrane
XCAW_RS06860	COG0424	maF-like protein
XCAW_RS06870	COG3164	Protein of unknown function
XCAW_RS06880	COG0312	modulator of DNA gyrase
XCAW_RS06885	COG3028	Belongs to the UPF0307 family
XCAW_RS06890	COG0312	modulator of DNA gyrase
XCAW_RS06900	COG4104	PAAR repeat-containing protein
XCAW_RS06905	COG0142	geranyltranstransferase activity
XCAW_RS06910	COG1722	exodeoxyribonuclease VII activity
XCAW_RS06915	COG0037	tRNA processing
XCAW_RS06920	COG1785	Belongs to the alkaline phosphatase family
XCAW_RS06925	COG1301	dicarboxylic acid transport
XCAW_RS06930	COG4106	trans-aconitate 2-methyltransferase activity
XCAW_RS06940	COG0791	NLP P60 protein
XCAW_RS06945	COG0791	NLP P60 protein
XCAW_RS06950	COG1047	Peptidyl-prolyl cis-trans
XCAW_RS06955	COG2311	Membrane
XCAW_RS06960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCAW_RS06965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XCAW_RS06985	COG3590	peptidase
XCAW_RS06990	COG3590	peptidase
XCAW_RS07010	COG0489	protein tyrosine kinase activity
XCAW_RS07015	COG0717	Belongs to the dCTP deaminase family
XCAW_RS07040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XCAW_RS07045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCAW_RS07060	COG0494	nUDIX hydrolase
XCAW_RS07065	COG0433	COG0433 Predicted ATPase
XCAW_RS07075	COG0688	phosphatidylethanolamine metabolic process
XCAW_RS07085	COG2890	protein-(glutamine-N5) methyltransferase activity
XCAW_RS07090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XCAW_RS07095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XCAW_RS07100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XCAW_RS07120	COG0101	tRNA pseudouridine synthase activity
XCAW_RS07125	COG0135	phosphoribosylanthranilate isomerase activity
XCAW_RS07135	COG0133	tryptophan synthase activity
XCAW_RS07145	COG0159	tryptophan synthase activity
XCAW_RS07150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XCAW_RS07155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XCAW_RS07190	COG0300	oxidoreductase activity
XCAW_RS07195	COG0149	triose-phosphate isomerase activity
XCAW_RS07210	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCAW_RS07215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCAW_RS07220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCAW_RS07225	COG0649	NAD binding
XCAW_RS07230	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XCAW_RS07235	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XCAW_RS07245	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XCAW_RS07250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCAW_RS07275	COG1007	ATP synthesis coupled electron transport
XCAW_RS07285	COG0779	Required for maturation of 30S ribosomal subunits
XCAW_RS07290	COG0195	Participates in both transcription termination and antitermination
XCAW_RS07295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XCAW_RS07300	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XCAW_RS07305	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XCAW_RS07310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XCAW_RS07315	COG1185	polyribonucleotide nucleotidyltransferase activity
XCAW_RS07350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XCAW_RS07360	COG2095	MarC family integral membrane protein
XCAW_RS07370	COG1611	Belongs to the LOG family
XCAW_RS07375	COG3275	phosphorelay sensor kinase activity
XCAW_RS07400	COG2963	transposase activity
XCAW_RS07435	COG2003	Belongs to the UPF0758 family
XCAW_RS07440	COG5489	Protein of unknown function (DUF736)
XCAW_RS07445	COG1396	sequence-specific DNA binding
XCAW_RS07450	COG2963	transposase activity
XCAW_RS07460	COG3002	Belongs to the UPF0753 family
XCAW_RS07465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XCAW_RS07470	COG0583	DNA-binding transcription factor activity
XCAW_RS07490	COG2197	response regulator
XCAW_RS07505	COG1335	isochorismatase
XCAW_RS07520	COG2814	Major facilitator Superfamily
XCAW_RS07535	COG1648	precorrin-2 dehydrogenase activity
XCAW_RS07535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XCAW_RS07555	COG3685	Protein conserved in bacteria
XCAW_RS07570	COG5001	Diguanylate cyclase
XCAW_RS07580	COG4566	intracellular signal transduction
XCAW_RS07630	COG3279	Response regulator of the LytR AlgR family
XCAW_RS07665	COG1238	metal cluster binding
XCAW_RS07675	COG2963	transposase activity
XCAW_RS07680	COG2801	Transposase and inactivated derivatives
XCAW_RS07740	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS07750	COG1073	alpha beta
XCAW_RS07750	COG2226	methyltransferase
XCAW_RS07795	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XCAW_RS07795	COG0316	Belongs to the HesB IscA family
XCAW_RS07800	COG2154	pterin-4-alpha-carbinolamine dehydratase
XCAW_RS07810	COG0428	transporter
XCAW_RS07815	COG3064	Membrane
XCAW_RS07825	COG1530	ribonuclease E activity
XCAW_RS07835	COG1054	Belongs to the UPF0176 family
XCAW_RS07855	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XCAW_RS07865	COG0582	viral genome integration into host DNA
XCAW_RS07870	COG2963	transposase activity
XCAW_RS07875	COG2801	Transposase and inactivated derivatives
XCAW_RS07890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XCAW_RS07895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XCAW_RS07925	COG3039	Transposase
XCAW_RS07965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XCAW_RS07980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XCAW_RS08045	COG0629	single-stranded DNA binding
XCAW_RS08050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XCAW_RS08055	COG0270	DNA (cytosine-5-)-methyltransferase activity
XCAW_RS08100	COG2826	transposase and inactivated derivatives, IS30 family
XCAW_RS08225	COG2003	Belongs to the UPF0758 family
XCAW_RS08310	COG0583	DNA-binding transcription factor activity
XCAW_RS08315	COG1396	sequence-specific DNA binding
XCAW_RS08335	COG0582	viral genome integration into host DNA
XCAW_RS08345	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XCAW_RS08350	COG0322	excinuclease ABC activity
XCAW_RS08360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XCAW_RS08365	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XCAW_RS08370	COG1663	tetraacyldisaccharide 4'-kinase activity
XCAW_RS08375	COG1132	(ABC) transporter
XCAW_RS08385	COG0811	peptide transport
XCAW_RS08400	COG1136	(ABC) transporter
XCAW_RS08405	COG4591	ABC-type transport system involved in lipoprotein release permease component
XCAW_RS08415	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XCAW_RS08420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XCAW_RS08435	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XCAW_RS08455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XCAW_RS08460	COG0837	glucose binding
XCAW_RS08465	COG0363	glucosamine-6-phosphate deaminase activity
XCAW_RS08470	COG0129	dihydroxy-acid dehydratase activity
XCAW_RS08475	COG0800	Aldolase
XCAW_RS08540	COG2205	protein histidine kinase activity
XCAW_RS08540	COG0784	Response regulator, receiver
XCAW_RS08545	COG2183	response to ionizing radiation
XCAW_RS08555	COG0723	plastoquinol--plastocyanin reductase activity
XCAW_RS08555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCAW_RS08570	COG3243	poly(R)-hydroxyalkanoic acid synthase
XCAW_RS08580	COG1183	phosphatidylcholine synthase activity
XCAW_RS08585	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS08600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XCAW_RS08610	COG0668	transmembrane transport
XCAW_RS08615	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XCAW_RS08630	COG1914	H( )-stimulated, divalent metal cation uptake system
XCAW_RS08645	COG0746	molybdenum cofactor guanylyltransferase activity
XCAW_RS08650	COG0303	'Molybdopterin
XCAW_RS08660	COG0708	Exodeoxyribonuclease III
XCAW_RS08695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XCAW_RS08700	COG0303	'Molybdopterin
XCAW_RS08705	COG1160	GTP binding
XCAW_RS08710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCAW_RS08720	COG1426	Protein conserved in bacteria
XCAW_RS08730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XCAW_RS08745	COG1024	Enoyl-CoA hydratase
XCAW_RS08745	COG1250	3-hydroxyacyl-CoA dehydrogenase
XCAW_RS08750	COG0183	Belongs to the thiolase family
XCAW_RS08760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XCAW_RS08765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XCAW_RS08775	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XCAW_RS08785	COG1674	ftsk spoiiie
XCAW_RS08790	COG0492	ferredoxin-NADP+ reductase activity
XCAW_RS08800	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XCAW_RS08810	COG0542	response to heat
XCAW_RS08825	COG0482	sulfurtransferase activity
XCAW_RS08830	COG2915	High frequency lysogenization protein hflD homolog
XCAW_RS08860	COG5002	protein histidine kinase activity
XCAW_RS08880	COG0784	Response regulator, receiver
XCAW_RS08880	COG0835	chemotaxis
XCAW_RS08890	COG1558	bacterial-type flagellum-dependent cell motility
XCAW_RS08895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XCAW_RS08905	COG4787	bacterial-type flagellum-dependent cell motility
XCAW_RS08915	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XCAW_RS08920	COG1706	bacterial-type flagellum-dependent cell motility
XCAW_RS08925	COG1705	Flagellar rod assembly protein muramidase FlgJ
XCAW_RS08925	COG3951	Flagellar rod assembly protein muramidase FlgJ
XCAW_RS08935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XCAW_RS08940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XCAW_RS08945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XCAW_RS08975	COG2201	protein-glutamate methylesterase activity
XCAW_RS08995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCAW_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS09005	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS09035	COG1677	Flagellar hook-basal body complex protein FliE
XCAW_RS09085	COG3190	flagellar
XCAW_RS09100	COG1684	flagellar biosynthetic protein fliR
XCAW_RS09130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XCAW_RS09160	COG0643	Histidine kinase
XCAW_RS09160	COG0784	Response regulator, receiver
XCAW_RS09160	COG2198	Histidine kinase
XCAW_RS09170	COG0641	radical SAM
XCAW_RS09190	COG2963	transposase activity
XCAW_RS09195	COG2801	Transposase and inactivated derivatives
XCAW_RS09240	COG0210	DNA helicase
XCAW_RS09320	COG2084	Dehydrogenase
XCAW_RS09340	COG2003	Belongs to the UPF0758 family
XCAW_RS09375	COG0582	viral genome integration into host DNA
XCAW_RS09380	COG0519	Catalyzes the synthesis of GMP from XMP
XCAW_RS09380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XCAW_RS09390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XCAW_RS09400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XCAW_RS09400	COG0475	glutathione-regulated potassium exporter activity
XCAW_RS09405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XCAW_RS09415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XCAW_RS09420	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XCAW_RS09430	COG0776	regulation of translation
XCAW_RS09435	COG0539	negative regulation of cytoplasmic translation
XCAW_RS09440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XCAW_RS09455	COG2957	Belongs to the agmatine deiminase family
XCAW_RS09460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XCAW_RS09485	COG0395	ABC-type sugar transport system, permease component
XCAW_RS09490	COG1175	transmembrane transport
XCAW_RS09520	COG2350	Protein conserved in bacteria
XCAW_RS09525	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XCAW_RS09530	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XCAW_RS09535	COG1187	pseudouridine synthase activity
XCAW_RS09555	COG0436	Aminotransferase
XCAW_RS09560	COG4133	protoheme IX ABC transporter activity
XCAW_RS09580	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XCAW_RS09585	COG1138	Cytochrome C-type biogenesis protein
XCAW_RS09605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCAW_RS09610	COG1278	Cold shock
XCAW_RS09615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XCAW_RS09620	COG4988	ABC transporter
XCAW_RS09630	COG1294	oxidase, subunit
XCAW_RS09655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XCAW_RS09660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XCAW_RS09670	COG0165	Argininosuccinate lyase
XCAW_RS09675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XCAW_RS09685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XCAW_RS09690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XCAW_RS09700	COG0137	argininosuccinate synthase activity
XCAW_RS09705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XCAW_RS09715	COG0215	cysteine-tRNA ligase activity
XCAW_RS09720	COG2166	iron-sulfur cluster assembly
XCAW_RS09740	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XCAW_RS09745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XCAW_RS09770	COG4302	ethanolamine ammonia-lyase activity
XCAW_RS09800	COG2963	transposase activity
XCAW_RS09820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XCAW_RS09825	COG0402	S-adenosylhomocysteine deaminase activity
XCAW_RS09835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XCAW_RS09840	COG1509	lysine 2,3-aminomutase activity
XCAW_RS09845	COG5001	Diguanylate cyclase
XCAW_RS09845	COG3300	MHYT domain
XCAW_RS09860	COG0483	inositol monophosphate 1-phosphatase activity
XCAW_RS09865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XCAW_RS09880	COG0488	(ABC) transporter
XCAW_RS09885	COG0513	Belongs to the DEAD box helicase family
XCAW_RS09890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XCAW_RS09895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XCAW_RS09905	COG0625	glutathione transferase activity
XCAW_RS09915	COG4681	YaeQ
XCAW_RS09920	COG2081	HI0933 family
XCAW_RS09930	COG0501	Belongs to the peptidase M48B family
XCAW_RS09935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCAW_RS09940	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS09960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XCAW_RS09965	COG0860	N-Acetylmuramoyl-L-alanine amidase
XCAW_RS09970	COG0802	atpase or kinase
XCAW_RS09975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XCAW_RS09975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XCAW_RS09980	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XCAW_RS09985	COG1570	exodeoxyribonuclease VII activity
XCAW_RS09995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XCAW_RS10175	COG0835	chemotaxis
XCAW_RS10180	COG0840	transmembrane signaling receptor activity
XCAW_RS10185	COG2094	Belongs to the DNA glycosylase MPG family
XCAW_RS10190	COG1201	RNA secondary structure unwinding
XCAW_RS10205	COG2969	positive regulation of protein catabolic process
XCAW_RS10210	COG0625	glutathione transferase activity
XCAW_RS10215	COG2857	Cytochrome c1
XCAW_RS10220	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XCAW_RS10225	COG0723	plastoquinol--plastocyanin reductase activity
XCAW_RS10230	COG0741	lytic transglycosylase activity
XCAW_RS10245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XCAW_RS10250	COG1702	phosphate starvation-inducible protein PhoH
XCAW_RS10260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XCAW_RS10270	COG4535	Mg2 and Co2 transporter CorC
XCAW_RS10285	COG1012	belongs to the aldehyde dehydrogenase family
XCAW_RS10295	COG1177	transmembrane transport
XCAW_RS10300	COG1176	ABC-type spermidine putrescine transport system, permease component I
XCAW_RS10305	COG3842	ATPase activity
XCAW_RS10325	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XCAW_RS10340	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XCAW_RS10345	COG0174	glutamine synthetase
XCAW_RS10350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCAW_RS10360	COG2703	oxygen carrier activity
XCAW_RS10365	COG0477	Major facilitator Superfamily
XCAW_RS10375	COG0243	molybdopterin cofactor binding
XCAW_RS10380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XCAW_RS10385	COG2223	nitrite transmembrane transporter activity
XCAW_RS10395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XCAW_RS10405	COG2733	membrane
XCAW_RS10410	COG5002	protein histidine kinase activity
XCAW_RS10410	COG0784	Response regulator, receiver
XCAW_RS10410	COG2205	protein histidine kinase activity
XCAW_RS10420	COG0477	Major facilitator Superfamily
XCAW_RS10425	COG2902	Dehydrogenase
XCAW_RS10435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCAW_RS10440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCAW_RS10445	COG1609	Transcriptional regulator
XCAW_RS10455	COG1105	Belongs to the carbohydrate kinase PfkB family
XCAW_RS10460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XCAW_RS10460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XCAW_RS10505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XCAW_RS10515	COG1862	Preprotein translocase
XCAW_RS10520	COG0343	queuine tRNA-ribosyltransferase activity
XCAW_RS10525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XCAW_RS10565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XCAW_RS10570	COG3291	Pkd domain containing protein
XCAW_RS10580	COG0405	Gamma-glutamyltransferase
XCAW_RS10585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XCAW_RS10600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XCAW_RS10605	COG0742	ribosomal rna small subunit methyltransferase
XCAW_RS10610	COG0326	Molecular chaperone. Has ATPase activity
XCAW_RS10680	COG0531	amino acid
XCAW_RS10695	COG0006	proline dipeptidase activity
XCAW_RS10705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XCAW_RS10720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCAW_RS10725	COG3938	Belongs to the proline racemase family
XCAW_RS10735	COG0552	protein localization to endoplasmic reticulum
XCAW_RS10740	COG1194	a g-specific adenine glycosylase
XCAW_RS10745	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XCAW_RS10750	COG4191	Histidine kinase
XCAW_RS10750	COG0784	Response regulator, receiver
XCAW_RS10765	COG0322	excinuclease ABC activity
XCAW_RS10780	COG3040	lipid binding
XCAW_RS10790	COG1960	acyl-CoA dehydrogenase activity
XCAW_RS10800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XCAW_RS10820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCAW_RS10825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCAW_RS10830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCAW_RS10855	COG0438	transferase activity, transferring glycosyl groups
XCAW_RS10865	COG0438	transferase activity, transferring glycosyl groups
XCAW_RS10870	COG0438	transferase activity, transferring glycosyl groups
XCAW_RS10920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCAW_RS10920	COG0072	phenylalanine-tRNA ligase activity
XCAW_RS10925	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XCAW_RS10940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XCAW_RS10945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XCAW_RS10970	COG1082	Xylose isomerase domain protein TIM barrel
XCAW_RS10985	COG0366	Alpha amylase catalytic
XCAW_RS10990	COG2963	transposase activity
XCAW_RS10995	COG2801	Transposase and inactivated derivatives
XCAW_RS11005	COG0477	Major facilitator Superfamily
XCAW_RS11010	COG2115	Belongs to the xylose isomerase family
XCAW_RS11015	COG1070	Carbohydrate kinase
XCAW_RS11025	COG1501	Belongs to the glycosyl hydrolase 31 family
XCAW_RS11065	COG0800	Aldolase
XCAW_RS11070	COG4948	Mandelate Racemase Muconate Lactonizing
XCAW_RS11080	COG3734	2-keto-3-deoxy-galactonokinase
XCAW_RS11085	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XCAW_RS11095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XCAW_RS11110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XCAW_RS11115	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XCAW_RS11130	COG0352	thiamine-phosphate diphosphorylase activity
XCAW_RS11130	COG0351	phosphomethylpyrimidine kinase
XCAW_RS11155	COG0583	DNA-binding transcription factor activity
XCAW_RS11165	COG1741	Belongs to the pirin family
XCAW_RS11180	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XCAW_RS11185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XCAW_RS11190	COG2137	regulation of response to DNA damage stimulus
XCAW_RS11195	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XCAW_RS11200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XCAW_RS11210	COG1546	Belongs to the CinA family
XCAW_RS11215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XCAW_RS11225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XCAW_RS11230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XCAW_RS11240	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XCAW_RS11245	COG1534	Rna-binding protein
XCAW_RS11260	COG1238	metal cluster binding
XCAW_RS11265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XCAW_RS11270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XCAW_RS11275	COG2840	Smr protein MutS2
XCAW_RS11280	COG0585	pseudouridine synthase activity
XCAW_RS11285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XCAW_RS11290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XCAW_RS11295	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XCAW_RS11300	COG0148	phosphopyruvate hydratase activity
XCAW_RS11310	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XCAW_RS11315	COG0504	CTP synthase activity
XCAW_RS11340	COG0306	phosphate transporter
XCAW_RS11350	COG1253	flavin adenine dinucleotide binding
XCAW_RS11365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCAW_RS11370	COG0477	Major facilitator Superfamily
XCAW_RS11380	COG1136	(ABC) transporter
XCAW_RS11395	COG0438	transferase activity, transferring glycosyl groups
XCAW_RS11405	COG2264	protein methyltransferase activity
XCAW_RS11435	COG2244	polysaccharide biosynthetic process
XCAW_RS11490	COG1595	DNA-templated transcription, initiation
XCAW_RS11505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XCAW_RS11515	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XCAW_RS11525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCAW_RS11540	COG0784	Response regulator, receiver
XCAW_RS11540	COG4191	Histidine kinase
XCAW_RS11545	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XCAW_RS11580	COG0840	transmembrane signaling receptor activity
XCAW_RS11605	COG2963	transposase activity
XCAW_RS11610	COG1396	sequence-specific DNA binding
XCAW_RS11615	COG5489	Protein of unknown function (DUF736)
XCAW_RS11620	COG2003	Belongs to the UPF0758 family
XCAW_RS11645	COG0582	viral genome integration into host DNA
XCAW_RS11660	COG4774	siderophore transport
XCAW_RS11675	COG2336	PFAM SpoVT AbrB
XCAW_RS11700	COG4206	TonB-dependent receptor
XCAW_RS11725	COG2273	Hydrolase Family 16
XCAW_RS11725	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XCAW_RS11740	COG2274	protein secretion by the type I secretion system
XCAW_RS11795	COG0270	DNA (cytosine-5-)-methyltransferase activity
XCAW_RS11845	COG4804	nuclease activity
XCAW_RS11850	COG2963	transposase activity
XCAW_RS11930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XCAW_RS11935	COG1360	Flagellar Motor Protein
XCAW_RS11945	COG0835	chemotaxis
XCAW_RS11955	COG0745	RESPONSE REGULATOR receiver
XCAW_RS11960	COG0643	Histidine kinase
XCAW_RS11960	COG2198	Histidine kinase
XCAW_RS11965	COG0840	transmembrane signaling receptor activity
XCAW_RS11985	COG0840	transmembrane signaling receptor activity
XCAW_RS11995	COG0840	transmembrane signaling receptor activity
XCAW_RS12000	COG0840	transmembrane signaling receptor activity
XCAW_RS12005	COG0840	transmembrane signaling receptor activity
XCAW_RS12010	COG0840	transmembrane signaling receptor activity
XCAW_RS12020	COG0840	transmembrane signaling receptor activity
XCAW_RS12025	COG0840	transmembrane signaling receptor activity
XCAW_RS12030	COG0840	transmembrane signaling receptor activity
XCAW_RS12035	COG0840	transmembrane signaling receptor activity
XCAW_RS12040	COG0840	transmembrane signaling receptor activity
XCAW_RS12050	COG0835	chemotaxis
XCAW_RS12060	COG0840	transmembrane signaling receptor activity
XCAW_RS12070	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XCAW_RS12075	COG2201	protein-glutamate methylesterase activity
XCAW_RS12085	COG2267	carboxylic ester hydrolase activity
XCAW_RS12120	COG0318	PFAM AMP-dependent synthetase and ligase
XCAW_RS12125	COG1024	Enoyl-CoA hydratase
XCAW_RS12130	COG0784	Response regulator, receiver
XCAW_RS12130	COG2198	Histidine kinase
XCAW_RS12130	COG2205	protein histidine kinase activity
XCAW_RS12140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XCAW_RS12145	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XCAW_RS12150	COG3279	Response regulator of the LytR AlgR family
XCAW_RS12195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XCAW_RS12205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCAW_RS12210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XCAW_RS12220	COG0505	Belongs to the CarA family
XCAW_RS12225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XCAW_RS12230	COG2258	MOSC domain
XCAW_RS12235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XCAW_RS12280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XCAW_RS12300	COG0277	FAD linked oxidase domain protein
XCAW_RS12305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XCAW_RS12315	COG0531	amino acid
XCAW_RS12320	COG0531	amino acid
XCAW_RS12325	COG0235	Class ii aldolase
XCAW_RS12330	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XCAW_RS12335	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XCAW_RS12350	COG0140	phosphoribosyl-ATP diphosphatase activity
XCAW_RS12350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XCAW_RS12355	COG0107	imidazoleglycerol-phosphate synthase activity
XCAW_RS12360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XCAW_RS12365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XCAW_RS12370	COG0131	Imidazoleglycerol-phosphate dehydratase
XCAW_RS12370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XCAW_RS12375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCAW_RS12380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XCAW_RS12385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XCAW_RS12395	COG0124	histidyl-tRNA synthetase
XCAW_RS12400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XCAW_RS12440	COG3210	domain, Protein
XCAW_RS12445	COG3210	domain, Protein
XCAW_RS12460	COG0726	polysaccharide deacetylase
XCAW_RS12460	COG1649	PFAM Uncharacterised BCR, COG1649
XCAW_RS12465	COG1215	transferase activity, transferring glycosyl groups
XCAW_RS12480	COG1012	belongs to the aldehyde dehydrogenase family
XCAW_RS12495	COG0167	dihydroorotate dehydrogenase activity
XCAW_RS12500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XCAW_RS12505	COG0697	spore germination
XCAW_RS12510	COG1794	racemase activity, acting on amino acids and derivatives
XCAW_RS12520	COG0671	phosphoesterase, PA-phosphatase related
XCAW_RS12525	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XCAW_RS12535	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XCAW_RS12540	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCAW_RS12545	COG2203	Gaf domain
XCAW_RS12545	COG5001	Diguanylate cyclase
XCAW_RS12545	COG4251	negative regulation of phosphorylation
XCAW_RS12545	COG3706	GGDEF domain
XCAW_RS12555	COG1472	Belongs to the glycosyl hydrolase 3 family
XCAW_RS12575	COG0166	Belongs to the GPI family
XCAW_RS12580	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XCAW_RS12585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XCAW_RS12590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XCAW_RS12610	COG1469	GTP cyclohydrolase I activity
XCAW_RS12615	COG0860	N-Acetylmuramoyl-L-alanine amidase
XCAW_RS12620	COG0366	Alpha amylase catalytic
XCAW_RS12625	COG2963	transposase activity
XCAW_RS12630	COG2801	Transposase and inactivated derivatives
XCAW_RS12695	COG2948	multi-organism process
XCAW_RS12715	COG3505	Type IV secretory pathway VirD4
XCAW_RS12730	COG0556	nucleotide-excision repair
XCAW_RS12765	COG2963	transposase activity
XCAW_RS12805	COG0583	DNA-binding transcription factor activity
XCAW_RS12810	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XCAW_RS12815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XCAW_RS12830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XCAW_RS12835	COG1605	Chorismate mutase
XCAW_RS12835	COG0077	Prephenate dehydratase
XCAW_RS12840	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XCAW_RS12845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XCAW_RS12850	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XCAW_RS12895	COG1228	amidohydrolase
XCAW_RS12900	COG2986	histidine ammonia-lyase
XCAW_RS12910	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XCAW_RS12925	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XCAW_RS12935	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XCAW_RS12940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XCAW_RS12945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCAW_RS12955	COG3115	cell septum assembly
XCAW_RS12965	COG0359	binds to the 23S rRNA
XCAW_RS12970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XCAW_RS12975	COG0360	Binds together with S18 to 16S ribosomal RNA
XCAW_RS12980	COG0316	Belongs to the HesB IscA family
XCAW_RS12985	COG0017	Asparaginyl-tRNA synthetase
XCAW_RS13005	COG2808	Putative FMN-binding domain
XCAW_RS13065	COG0288	reversible hydration of carbon dioxide
XCAW_RS13070	COG0662	Cupin 2, conserved barrel domain protein
XCAW_RS13080	COG3844	kynureninase activity
XCAW_RS13085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCAW_RS13090	COG2925	Exonuclease
XCAW_RS13115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XCAW_RS13125	COG0488	(ABC) transporter
XCAW_RS13160	COG0494	nUDIX hydrolase
XCAW_RS13170	COG1024	Enoyl-CoA hydratase
XCAW_RS13180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XCAW_RS13185	COG0659	secondary active sulfate transmembrane transporter activity
XCAW_RS13210	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XCAW_RS13215	COG0573	inorganic phosphate transmembrane transporter activity
XCAW_RS13220	COG0581	inorganic phosphate transmembrane transporter activity
XCAW_RS13225	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XCAW_RS13230	COG0704	Plays a role in the regulation of phosphate uptake
XCAW_RS13240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XCAW_RS13250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XCAW_RS13260	COG0557	exoribonuclease II activity
XCAW_RS13275	COG1960	acyl-CoA dehydrogenase activity
XCAW_RS13280	COG2226	methyltransferase
XCAW_RS13285	COG1410	methionine synthase
XCAW_RS13285	COG0646	methionine synthase
XCAW_RS13290	COG0646	methionine synthase
XCAW_RS13290	COG1410	methionine synthase
XCAW_RS13300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCAW_RS13325	COG2900	Belongs to the SlyX family
XCAW_RS13340	COG0386	Belongs to the glutathione peroxidase family
XCAW_RS13345	COG1725	Transcriptional regulator
XCAW_RS13350	COG1131	(ABC) transporter
XCAW_RS13380	COG1253	flavin adenine dinucleotide binding
XCAW_RS13400	COG2850	peptidyl-arginine hydroxylation
XCAW_RS13435	COG1132	(ABC) transporter
XCAW_RS13440	COG0583	DNA-binding transcription factor activity
XCAW_RS13470	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XCAW_RS13475	COG0484	heat shock protein binding
XCAW_RS13480	COG0443	Heat shock 70 kDa protein
XCAW_RS13485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XCAW_RS13490	COG1420	regulation of RNA biosynthetic process
XCAW_RS13495	COG0497	DNA recombination
XCAW_RS13505	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCAW_RS13520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XCAW_RS13615	COG3706	GGDEF domain
XCAW_RS13660	COG0583	DNA-binding transcription factor activity
XCAW_RS13670	COG0415	Belongs to the DNA photolyase family
XCAW_RS13675	COG0305	Participates in initiation and elongation during chromosome replication
XCAW_RS13685	COG0367	asparagine synthase
XCAW_RS13705	COG1960	acyl-CoA dehydrogenase activity
XCAW_RS13720	COG0084	hydrolase, TatD family'
XCAW_RS13725	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XCAW_RS13780	COG0386	Belongs to the glutathione peroxidase family
XCAW_RS13785	COG0339	signal peptide processing
XCAW_RS13835	COG2814	Major facilitator Superfamily
XCAW_RS13840	COG1566	PFAM secretion protein HlyD family protein
XCAW_RS13870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XCAW_RS13885	COG4774	siderophore transport
XCAW_RS13895	COG0367	asparagine synthase
XCAW_RS13900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XCAW_RS13905	COG1393	Belongs to the ArsC family
XCAW_RS13915	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XCAW_RS13955	COG0052	Belongs to the universal ribosomal protein uS2 family
XCAW_RS13960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XCAW_RS13970	COG0528	UMP kinase activity
XCAW_RS13975	COG0233	cytoplasmic translational termination
XCAW_RS13980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XCAW_RS13985	COG0575	Belongs to the CDS family
XCAW_RS13990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XCAW_RS13995	COG0750	zinc metalloprotease
XCAW_RS14010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCAW_RS14015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XCAW_RS14020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCAW_RS14025	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCAW_RS14030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XCAW_RS14040	COG0825	malonyl-CoA metabolic process
XCAW_RS14055	COG1981	membrane
XCAW_RS14075	COG1695	Transcriptional regulator
XCAW_RS14095	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XCAW_RS14105	COG2040	homocysteine
XCAW_RS14110	COG0833	amino acid
XCAW_RS14115	COG0346	lactoylglutathione lyase activity
XCAW_RS14120	COG1131	(ABC) transporter
XCAW_RS14135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCAW_RS14135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCAW_RS14145	COG2878	Part of a membrane complex involved in electron transport
XCAW_RS14165	COG1595	DNA-templated transcription, initiation
XCAW_RS14190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XCAW_RS14205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XCAW_RS14210	COG0251	oxidation-reduction process
XCAW_RS14220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XCAW_RS14220	COG0392	lysyltransferase activity
XCAW_RS14255	COG2814	Major facilitator Superfamily
XCAW_RS14260	COG1902	pentaerythritol trinitrate reductase activity
XCAW_RS14265	COG2824	Alkylphosphonate utilization operon protein PhnA
XCAW_RS14275	COG1047	Peptidyl-prolyl cis-trans
XCAW_RS14280	COG1077	Cell shape determining protein MreB Mrl
XCAW_RS14300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XCAW_RS14310	COG5487	UPF0391 membrane protein
XCAW_RS14315	COG1451	nucleotide metabolic process
XCAW_RS14335	COG0183	Belongs to the thiolase family
XCAW_RS14365	COG1793	dna ligase
XCAW_RS14365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XCAW_RS14375	COG1793	dna ligase
XCAW_RS14380	COG1201	RNA secondary structure unwinding
XCAW_RS14390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCAW_RS14395	COG1278	Cold shock
XCAW_RS14400	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XCAW_RS14405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XCAW_RS14410	COG1472	Belongs to the glycosyl hydrolase 3 family
XCAW_RS14415	COG3046	protein related to deoxyribodipyrimidine photolyase
XCAW_RS14420	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
XCAW_RS14425	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XCAW_RS14430	COG2954	triphosphatase activity
XCAW_RS14435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XCAW_RS14445	COG1381	Involved in DNA repair and RecF pathway recombination
XCAW_RS14450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XCAW_RS14455	COG0571	ribonuclease III activity
XCAW_RS14470	COG0481	GTPase activity
XCAW_RS14475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XCAW_RS14490	COG1024	Enoyl-CoA hydratase
XCAW_RS14490	COG1250	3-hydroxyacyl-CoA dehydrogenase
XCAW_RS14510	COG1024	Enoyl-CoA hydratase
XCAW_RS14515	COG1960	acyl-CoA dehydrogenase activity
XCAW_RS14535	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XCAW_RS14540	COG3250	beta-galactosidase activity
XCAW_RS14560	COG3209	COG3209 Rhs family protein
XCAW_RS14570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XCAW_RS14580	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XCAW_RS14605	COG0534	Mate efflux family protein
XCAW_RS14610	COG0335	large ribosomal subunit rRNA binding
XCAW_RS14615	COG0336	Belongs to the RNA methyltransferase TrmD family
XCAW_RS14620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XCAW_RS14625	COG0228	four-way junction DNA binding
XCAW_RS14630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XCAW_RS14645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XCAW_RS14650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XCAW_RS14680	COG4191	Histidine kinase
XCAW_RS14680	COG0784	Response regulator, receiver
XCAW_RS14685	COG3850	Histidine kinase
XCAW_RS14685	COG2205	protein histidine kinase activity
XCAW_RS14685	COG3437	response regulator, receiver
XCAW_RS14685	COG4999	Histidine kinase
XCAW_RS14690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XCAW_RS14700	COG2205	protein histidine kinase activity
XCAW_RS14705	COG5507	3-demethylubiquinone-9 3-methyltransferase
XCAW_RS14715	COG4771	TonB-dependent receptor
XCAW_RS14740	COG2172	sigma factor antagonist activity
XCAW_RS14745	COG1366	Belongs to the anti-sigma-factor antagonist family
XCAW_RS14750	COG1366	Belongs to the anti-sigma-factor antagonist family
XCAW_RS14760	COG0326	Molecular chaperone. Has ATPase activity
XCAW_RS14765	COG2207	Transcriptional regulator
XCAW_RS14775	COG3152	Membrane
XCAW_RS14790	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XCAW_RS14795	COG1845	cytochrome c oxidase, subunit III
XCAW_RS14800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XCAW_RS14815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XCAW_RS14820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XCAW_RS14825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XCAW_RS14830	COG0196	riboflavin kinase activity
XCAW_RS14840	COG0268	Binds directly to 16S ribosomal RNA
XCAW_RS14845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XCAW_RS14850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XCAW_RS14855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XCAW_RS14860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XCAW_RS14865	COG0824	Thioesterase
XCAW_RS14880	COG1946	Acyl-CoA thioesterase
XCAW_RS14900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XCAW_RS14910	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XCAW_RS14935	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XCAW_RS14950	COG2197	response regulator
XCAW_RS14955	COG4585	Histidine kinase
XCAW_RS14970	COG0850	regulation of cytokinetic process
XCAW_RS14975	COG2894	cell division
XCAW_RS14980	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XCAW_RS14990	COG0642	Histidine kinase
XCAW_RS14995	COG0745	RESPONSE REGULATOR receiver
XCAW_RS15010	COG2194	sulfuric ester hydrolase activity
XCAW_RS15025	COG2814	Major facilitator Superfamily
XCAW_RS15030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XCAW_RS15030	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XCAW_RS15040	COG0656	L-ascorbic acid biosynthetic process
XCAW_RS15045	COG0753	catalase activity
XCAW_RS15075	COG0643	Histidine kinase
XCAW_RS15075	COG2198	Histidine kinase
XCAW_RS15080	COG0840	transmembrane signaling receptor activity
XCAW_RS15085	COG0835	chemotaxis
XCAW_RS15090	COG2199	diguanylate cyclase activity
XCAW_RS15090	COG2200	EAL domain
XCAW_RS15090	COG2202	Pas domain
XCAW_RS15095	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XCAW_RS15100	COG2201	protein-glutamate methylesterase activity
XCAW_RS15105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCAW_RS15110	COG3590	peptidase
XCAW_RS15120	COG0588	phosphoglycerate mutase activity
XCAW_RS15125	COG1515	deoxyribonuclease V activity
XCAW_RS15135	COG1741	Belongs to the pirin family
XCAW_RS15150	COG1741	Belongs to the pirin family
XCAW_RS15155	COG1966	Carbon starvation protein
XCAW_RS15160	COG2879	small protein
XCAW_RS15205	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XCAW_RS15210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XCAW_RS15215	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XCAW_RS15220	COG2080	2 iron, 2 sulfur cluster binding
XCAW_RS15230	COG3706	GGDEF domain
XCAW_RS15230	COG5001	Diguanylate cyclase
XCAW_RS15230	COG2203	Gaf domain
XCAW_RS15230	COG4251	negative regulation of phosphorylation
XCAW_RS15235	COG0629	single-stranded DNA binding
XCAW_RS15240	COG0142	geranyltranstransferase activity
XCAW_RS15250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XCAW_RS15265	COG0527	aspartate kinase activity
XCAW_RS15270	COG0384	phenazine biosynthesis protein PhzF
XCAW_RS15275	COG0384	phenazine biosynthesis protein PhzF
XCAW_RS15285	COG1764	response to oxidative stress
XCAW_RS15290	COG0540	Belongs to the ATCase OTCase family
XCAW_RS15295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XCAW_RS15300	COG1678	Uncharacterized ACR, COG1678
XCAW_RS15310	COG0519	Catalyzes the synthesis of GMP from XMP
XCAW_RS15325	COG5297	Belongs to the glycosyl hydrolase family 6
XCAW_RS15340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XCAW_RS15355	COG0739	heme binding
XCAW_RS15375	COG0693	protein deglycase activity
XCAW_RS15385	COG1959	2 iron, 2 sulfur cluster binding
XCAW_RS15390	COG0719	Fe-S assembly protein
XCAW_RS15395	COG0396	ATPase activity
XCAW_RS15400	COG0719	Fe-S assembly protein
XCAW_RS15405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XCAW_RS15415	COG2146	nitrite reductase [NAD(P)H] activity
XCAW_RS15420	COG4774	siderophore transport
XCAW_RS15425	COG3128	pkhd-type hydroxylase
XCAW_RS15450	COG1477	protein flavinylation
XCAW_RS15455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XCAW_RS15470	COG1555	photosystem II stabilization
XCAW_RS15475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XCAW_RS15485	COG3178	'Phosphotransferase
XCAW_RS15490	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XCAW_RS15500	COG0628	permease
XCAW_RS15510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XCAW_RS15520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XCAW_RS15540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XCAW_RS15545	COG0271	Belongs to the BolA IbaG family
XCAW_RS15555	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XCAW_RS15565	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XCAW_RS15570	COG1137	ATPase activity
XCAW_RS15585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCAW_RS15590	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XCAW_RS15595	COG1660	Displays ATPase and GTPase activities
XCAW_RS15605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCAW_RS15610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XCAW_RS15615	COG2239	Acts as a magnesium transporter
XCAW_RS15625	COG1294	oxidase, subunit
XCAW_RS15630	COG1271	oxidase subunit
XCAW_RS15640	COG1113	amino acid transport
XCAW_RS15665	COG2197	response regulator
XCAW_RS15670	COG0531	amino acid
XCAW_RS15690	COG1234	tRNA 3'-trailer cleavage
XCAW_RS15725	COG2814	Major facilitator Superfamily
XCAW_RS15735	COG0754	glutathionylspermidine amidase activity
XCAW_RS15760	COG1842	Phage shock protein A
XCAW_RS15770	COG0259	pyridoxamine-phosphate oxidase activity
XCAW_RS15775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XCAW_RS15780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XCAW_RS15790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XCAW_RS15865	COG0477	Major facilitator Superfamily
XCAW_RS15885	COG2198	Histidine kinase
XCAW_RS15885	COG0784	Response regulator, receiver
XCAW_RS15885	COG2205	protein histidine kinase activity
XCAW_RS15890	COG2353	YceI-like domain
XCAW_RS15910	COG1760	l-serine dehydratase
XCAW_RS15920	COG0460	homoserine dehydrogenase
XCAW_RS15920	COG0527	aspartate kinase activity
XCAW_RS15925	COG0626	cystathionine gamma-synthase activity
XCAW_RS15930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCAW_RS15935	COG0739	heme binding
XCAW_RS15940	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XCAW_RS15945	COG1272	protein, Hemolysin III
XCAW_RS15950	COG2982	Protein involved in outer membrane biogenesis
XCAW_RS15955	COG0516	GMP reductase activity
XCAW_RS15955	COG0517	IMP dehydrogenase activity
XCAW_RS15960	COG0463	Glycosyl transferase, family 2
XCAW_RS15965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XCAW_RS15970	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XCAW_RS15980	COG4771	TonB-dependent receptor
XCAW_RS15990	COG1309	transcriptional regulator
XCAW_RS16000	COG1960	acyl-CoA dehydrogenase activity
XCAW_RS16025	COG0509	glycine decarboxylation via glycine cleavage system
XCAW_RS16030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XCAW_RS16040	COG0330	HflC and HflK could
XCAW_RS16045	COG1742	UPF0060 membrane protein
XCAW_RS16050	COG3956	TIGRFAM MazG family protein
XCAW_RS16060	COG0494	nUDIX hydrolase
XCAW_RS16070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XCAW_RS16075	COG0837	glucose binding
XCAW_RS16090	COG3858	chitin binding
XCAW_RS16090	COG1388	LysM domain
XCAW_RS16095	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XCAW_RS16105	COG1472	Belongs to the glycosyl hydrolase 3 family
XCAW_RS16120	COG0531	amino acid
XCAW_RS16130	COG1486	melibiose metabolic process
XCAW_RS16140	COG3537	Alpha-1,2-mannosidase
XCAW_RS16175	COG3142	Participates in the control of copper homeostasis
XCAW_RS16180	COG1446	asparaginase
XCAW_RS16210	COG0643	Histidine kinase
XCAW_RS16210	COG0784	Response regulator, receiver
XCAW_RS16210	COG2198	Histidine kinase
XCAW_RS16215	COG0840	transmembrane signaling receptor activity
XCAW_RS16220	COG0835	chemotaxis
XCAW_RS16235	COG0189	ligase activity
XCAW_RS16245	COG1397	ADP-ribosylglycohydrolase
XCAW_RS16255	COG1199	ATP-dependent helicase activity
XCAW_RS16265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XCAW_RS16270	COG1215	transferase activity, transferring glycosyl groups
XCAW_RS16280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XCAW_RS16285	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XCAW_RS16290	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XCAW_RS16295	COG0535	radical SAM domain protein
XCAW_RS16300	COG0535	radical SAM domain protein
XCAW_RS16315	COG0837	glucose binding
XCAW_RS16325	COG1643	Atp-dependent helicase
XCAW_RS16330	COG0783	Belongs to the Dps family
XCAW_RS16335	COG0514	ATP-dependent DNA helicase (RecQ)
XCAW_RS16370	COG0840	transmembrane signaling receptor activity
XCAW_RS16390	COG3920	Histidine kinase
XCAW_RS16395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XCAW_RS16405	COG0602	queuosine metabolic process
XCAW_RS16415	COG2885	chlorophyll binding
XCAW_RS16420	COG0823	Involved in the tonB-independent uptake of proteins
XCAW_RS16430	COG0848	biopolymer transport protein
XCAW_RS16440	COG0824	Thioesterase
XCAW_RS16445	COG2255	four-way junction helicase activity
XCAW_RS16455	COG3158	transport of potassium into the cell
XCAW_RS16460	COG0632	four-way junction helicase activity
XCAW_RS16465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XCAW_RS16470	COG0217	transcriptional regulatory protein
XCAW_RS16485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XCAW_RS16500	COG0477	Major facilitator Superfamily
XCAW_RS16535	COG0488	(ABC) transporter
XCAW_RS16570	COG4651	solute:proton antiporter activity
XCAW_RS16570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XCAW_RS16595	COG4772	TonB-dependent receptor
XCAW_RS16605	COG4264	IucA IucC family
XCAW_RS16620	COG0019	diaminopimelate decarboxylase activity
XCAW_RS16645	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XCAW_RS16655	COG1492	cobalamin metabolic process
XCAW_RS16665	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XCAW_RS16685	COG4206	TonB-dependent receptor
XCAW_RS16690	COG0542	response to heat
XCAW_RS16695	COG1116	anion transmembrane transporter activity
XCAW_RS16700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCAW_RS16705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XCAW_RS16710	COG0667	Aldo Keto reductase
XCAW_RS16715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCAW_RS16720	COG4771	TonB-dependent receptor
XCAW_RS16725	COG2827	Endonuclease containing a URI domain
XCAW_RS16765	COG1877	trehalose-phosphatase activity
XCAW_RS16770	COG3387	PFAM Glycoside hydrolase 15-related
XCAW_RS16785	COG0840	transmembrane signaling receptor activity
XCAW_RS16790	COG3011	Protein conserved in bacteria
XCAW_RS16805	COG0564	pseudouridine synthase activity
XCAW_RS16810	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCAW_RS16820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XCAW_RS16820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XCAW_RS16830	COG2963	transposase activity
XCAW_RS16850	COG2951	lytic endotransglycosylase activity
XCAW_RS16855	COG4644	lycopene metabolic process
XCAW_RS16905	COG2963	transposase activity
XCAW_RS16910	COG2801	Transposase and inactivated derivatives
XCAW_RS16940	COG0473	3-isopropylmalate dehydrogenase activity
XCAW_RS16955	COG4783	chaperone-mediated protein folding
XCAW_RS16970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XCAW_RS16980	COG0438	transferase activity, transferring glycosyl groups
XCAW_RS16985	COG0671	phosphoesterase, PA-phosphatase related
XCAW_RS16990	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCAW_RS17000	COG3291	Pkd domain containing protein
XCAW_RS17030	COG0285	dihydrofolate synthase activity
XCAW_RS17035	COG0406	alpha-ribazole phosphatase activity
XCAW_RS17060	COG1063	alcohol dehydrogenase
XCAW_RS17070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XCAW_RS17075	COG4208	sulfate ABC transporter
XCAW_RS17080	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XCAW_RS17085	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XCAW_RS17090	COG0156	8-amino-7-oxononanoate synthase activity
XCAW_RS17120	COG0604	alcohol dehydrogenase
XCAW_RS17125	COG0446	pyridine nucleotide-disulphide oxidoreductase
XCAW_RS17125	COG1902	pentaerythritol trinitrate reductase activity
XCAW_RS17135	COG0625	glutathione transferase activity
XCAW_RS17140	COG0039	L-malate dehydrogenase activity
XCAW_RS17145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XCAW_RS17150	COG1217	gtp-binding protein TYPA
XCAW_RS17160	COG0154	amidase activity
XCAW_RS17170	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XCAW_RS17185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XCAW_RS17190	COG0203	ribosomal protein L17
XCAW_RS17215	COG0201	protein transport
XCAW_RS17220	COG0200	Binds to the 23S rRNA
XCAW_RS17225	COG1841	ribosomal large subunit assembly
XCAW_RS17235	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XCAW_RS17240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XCAW_RS17245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XCAW_RS17255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XCAW_RS17260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XCAW_RS17270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XCAW_RS17275	COG0255	Belongs to the universal ribosomal protein uL29 family
XCAW_RS17280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XCAW_RS17285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XCAW_RS17295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XCAW_RS17300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XCAW_RS17305	COG0089	rRNA binding
XCAW_RS17310	COG0088	Forms part of the polypeptide exit tunnel
XCAW_RS17315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XCAW_RS17320	COG0051	transcription antitermination factor activity, RNA binding
XCAW_RS17325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XCAW_RS17330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XCAW_RS17335	COG0049	tRNA binding
XCAW_RS17340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XCAW_RS17345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XCAW_RS17350	COG0085	RNA polymerase activity
XCAW_RS17355	COG0222	ribosome binding
XCAW_RS17360	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XCAW_RS17365	COG0081	regulation of translation
XCAW_RS17370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XCAW_RS17375	COG0250	Participates in transcription elongation, termination and antitermination
XCAW_RS17390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XCAW_RS17410	COG0012	GTP binding
XCAW_RS17415	COG0193	aminoacyl-tRNA hydrolase activity
XCAW_RS17420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XCAW_RS17425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XCAW_RS17435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XCAW_RS17440	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XCAW_RS17450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XCAW_RS17455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XCAW_RS17465	COG0521	Mo-molybdopterin cofactor biosynthetic process
XCAW_RS17480	COG1254	Belongs to the acylphosphatase family
XCAW_RS17485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCAW_RS17490	COG1295	ribonuclease BN
XCAW_RS17515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XCAW_RS17520	COG1404	Belongs to the peptidase S8 family
XCAW_RS17525	COG1404	Belongs to the peptidase S8 family
XCAW_RS17530	COG1404	Belongs to the peptidase S8 family
XCAW_RS17535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XCAW_RS17550	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XCAW_RS17575	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XCAW_RS17605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XCAW_RS17605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XCAW_RS17625	COG2890	protein-(glutamine-N5) methyltransferase activity
XCAW_RS17635	COG3634	alkyl hydroperoxide reductase activity
XCAW_RS17640	COG0583	DNA-binding transcription factor activity
XCAW_RS17645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCAW_RS17650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XCAW_RS17660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XCAW_RS17670	COG2197	response regulator
XCAW_RS17675	COG5002	protein histidine kinase activity
XCAW_RS17675	COG2205	protein histidine kinase activity
XCAW_RS17675	COG0784	Response regulator, receiver
XCAW_RS17695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCAW_RS17705	COG0697	spore germination
XCAW_RS17730	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XCAW_RS17740	COG3386	PFAM SMP-30 Gluconolaconase
XCAW_RS17760	COG1024	Enoyl-CoA hydratase
XCAW_RS17775	COG0583	DNA-binding transcription factor activity
XCAW_RS17780	COG3384	dioxygenase
XCAW_RS17810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCAW_RS17815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCAW_RS17825	COG2096	Adenosyltransferase
XCAW_RS17830	COG0123	including yeast histone deacetylase and acetoin utilization protein
XCAW_RS17840	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XCAW_RS17845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XCAW_RS17850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XCAW_RS17855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XCAW_RS17860	COG2967	ApaG domain
XCAW_RS17865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XCAW_RS17875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XCAW_RS17885	COG0747	negative chemotaxis
XCAW_RS17910	COG0431	NADPH-dependent FMN reductase
XCAW_RS17915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCAW_RS17925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCAW_RS17930	COG1116	anion transmembrane transporter activity
XCAW_RS17940	COG3829	transcription factor binding
XCAW_RS17955	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XCAW_RS17960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XCAW_RS17980	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XCAW_RS17990	COG0642	Histidine kinase
XCAW_RS18005	COG4181	ATPase activity
XCAW_RS18015	COG2175	clavaminate synthase activity
XCAW_RS18025	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XCAW_RS18030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCAW_RS18050	COG4771	TonB-dependent receptor
XCAW_RS18060	COG0667	Aldo Keto reductase
XCAW_RS18065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XCAW_RS18070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCAW_RS18080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XCAW_RS18085	COG4106	trans-aconitate 2-methyltransferase activity
XCAW_RS18095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XCAW_RS18130	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XCAW_RS18140	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XCAW_RS18145	COG2226	methyltransferase
XCAW_RS18175	COG0366	Alpha amylase catalytic
XCAW_RS18195	COG3321	synthase
XCAW_RS18195	COG0604	alcohol dehydrogenase
XCAW_RS18195	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS18215	COG0494	nUDIX hydrolase
XCAW_RS18220	COG0653	protein targeting
XCAW_RS18225	COG0739	heme binding
XCAW_RS18235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XCAW_RS18250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XCAW_RS18255	COG1181	Belongs to the D-alanine--D-alanine ligase family
XCAW_RS18260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XCAW_RS18265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XCAW_RS18270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XCAW_RS18280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XCAW_RS18285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XCAW_RS18290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XCAW_RS18300	COG3116	cell division
XCAW_RS18305	COG0275	rRNA processing
XCAW_RS18335	COG0792	nuclease activity
XCAW_RS18340	COG1988	membrane-bound metal-dependent
XCAW_RS18345	COG0277	FAD linked oxidase domain protein
XCAW_RS18360	COG0745	RESPONSE REGULATOR receiver
XCAW_RS18365	COG2205	protein histidine kinase activity
XCAW_RS18370	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XCAW_RS18375	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XCAW_RS18380	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XCAW_RS18400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XCAW_RS18405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XCAW_RS18410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XCAW_RS18430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XCAW_RS18430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XCAW_RS18440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XCAW_RS18445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XCAW_RS18455	COG0488	(ABC) transporter
XCAW_RS18465	COG0697	spore germination
XCAW_RS18475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XCAW_RS18490	COG3791	Glutathione-dependent formaldehyde-activating
XCAW_RS18520	COG2205	protein histidine kinase activity
XCAW_RS18535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XCAW_RS18540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XCAW_RS18555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XCAW_RS18565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XCAW_RS18570	COG1012	belongs to the aldehyde dehydrogenase family
XCAW_RS18575	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XCAW_RS18580	COG0617	tRNA 3'-terminal CCA addition
XCAW_RS18590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XCAW_RS18595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XCAW_RS18600	COG1609	Transcriptional regulator
XCAW_RS18610	COG2188	Transcriptional regulator
XCAW_RS18625	COG3250	beta-galactosidase activity
XCAW_RS18675	COG1459	type II secretion system
XCAW_RS18730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XCAW_RS18735	COG4191	Histidine kinase
XCAW_RS18740	COG0784	Response regulator, receiver
XCAW_RS18745	COG4251	negative regulation of phosphorylation
XCAW_RS18750	COG2823	Periplasmic or secreted lipoprotein
XCAW_RS18755	COG0673	inositol 2-dehydrogenase activity
XCAW_RS18760	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XCAW_RS18795	COG1056	cytidyltransferase-related domain
XCAW_RS18795	COG1051	belongs to the nudix hydrolase family
XCAW_RS18805	COG0583	DNA-binding transcription factor activity
XCAW_RS18820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XCAW_RS18825	COG0321	lipoyl(octanoyl) transferase activity
XCAW_RS18830	COG2921	Belongs to the UPF0250 family
XCAW_RS18840	COG1686	Belongs to the peptidase S11 family
XCAW_RS18850	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XCAW_RS18855	COG2951	lytic endotransglycosylase activity
XCAW_RS18865	COG0772	Belongs to the SEDS family
XCAW_RS18880	COG1792	Involved in formation and maintenance of cell shape
XCAW_RS18885	COG1077	Cell shape determining protein MreB Mrl
XCAW_RS18890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCAW_RS18895	COG3284	Transcriptional regulator
XCAW_RS18945	COG0308	aminopeptidase N
XCAW_RS18950	COG5001	Diguanylate cyclase
XCAW_RS18950	COG3300	MHYT domain
XCAW_RS18955	COG2226	methyltransferase
XCAW_RS18980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XCAW_RS18985	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XCAW_RS18990	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XCAW_RS19000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XCAW_RS19010	COG2832	Protein of unknown function (DUF454)
XCAW_RS19020	COG0436	Aminotransferase
XCAW_RS19025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XCAW_RS19030	COG1505	serine-type exopeptidase activity
XCAW_RS19055	COG0181	hydroxymethylbilane synthase activity
XCAW_RS19065	COG3275	phosphorelay sensor kinase activity
XCAW_RS19075	COG2943	transferase activity, transferring hexosyl groups
XCAW_RS19105	COG5297	Belongs to the glycosyl hydrolase family 6
XCAW_RS19105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCAW_RS19110	COG0840	transmembrane signaling receptor activity
XCAW_RS19115	COG5001	Diguanylate cyclase
XCAW_RS19155	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XCAW_RS19175	COG1113	amino acid transport
XCAW_RS19200	COG0697	spore germination
XCAW_RS19240	COG1506	peptidase
XCAW_RS19240	COG0823	Involved in the tonB-independent uptake of proteins
XCAW_RS19245	COG2409	Drug exporters of the RND superfamily
XCAW_RS19270	COG0435	Glutathione S-transferase
XCAW_RS19295	COG2003	Belongs to the UPF0758 family
XCAW_RS19320	COG0784	Response regulator, receiver
XCAW_RS19320	COG4191	Histidine kinase
XCAW_RS19355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCAW_RS19365	COG2895	sulfate adenylyltransferase (ATP) activity
XCAW_RS19365	COG0529	Catalyzes the synthesis of activated sulfate
XCAW_RS19370	COG0175	sulfate reduction
XCAW_RS19375	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XCAW_RS19380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XCAW_RS19385	COG0175	sulfate reduction
XCAW_RS19405	COG2205	protein histidine kinase activity
XCAW_RS19405	COG2198	Histidine kinase
XCAW_RS19405	COG0784	Response regulator, receiver
XCAW_RS19425	COG1648	precorrin-2 dehydrogenase activity
XCAW_RS19425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XCAW_RS19445	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XCAW_RS19450	COG3588	fructose-bisphosphate aldolase
XCAW_RS19455	COG0469	pyruvate kinase activity
XCAW_RS19465	COG0126	phosphoglycerate kinase activity
XCAW_RS19485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XCAW_RS19495	COG3047	cAMP biosynthetic process
XCAW_RS19500	COG3047	cAMP biosynthetic process
XCAW_RS19510	COG3453	Protein conserved in bacteria
XCAW_RS19510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCAW_RS19515	COG0725	ABC transporter, periplasmic molybdate-binding protein
XCAW_RS19520	COG4149	molybdate abc transporter
XCAW_RS19525	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XCAW_RS19560	COG1376	ErfK ybiS ycfS ynhG family protein
XCAW_RS19565	COG0739	heme binding
XCAW_RS19575	COG4773	Receptor
XCAW_RS19595	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XCAW_RS19600	COG1301	dicarboxylic acid transport
XCAW_RS19610	COG2304	oxidoreductase activity
XCAW_RS19630	COG0714	Associated with various cellular activities
XCAW_RS19660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XCAW_RS19685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XCAW_RS19695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XCAW_RS19705	COG0194	GDP metabolic process
XCAW_RS19710	COG1561	YicC-like family, N-terminal region
XCAW_RS19715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XCAW_RS19725	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XCAW_RS19730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XCAW_RS19745	COG0006	proline dipeptidase activity
XCAW_RS19755	COG0006	proline dipeptidase activity
XCAW_RS19760	COG3079	Belongs to the UPF0149 family
XCAW_RS19775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XCAW_RS19785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XCAW_RS19795	COG2912	Transglutaminase-like superfamily
XCAW_RS19800	COG1773	rubredoxin
XCAW_RS19805	COG0352	thiamine-phosphate diphosphorylase activity
XCAW_RS19820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XCAW_RS19835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCAW_RS19865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XCAW_RS19870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XCAW_RS19875	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS19885	COG0671	phosphoesterase, PA-phosphatase related
XCAW_RS19890	COG3781	membrane
XCAW_RS19900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XCAW_RS19905	COG0563	adenylate kinase activity
XCAW_RS19920	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XCAW_RS19930	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XCAW_RS19950	COG3710	Transcriptional regulator
XCAW_RS19955	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XCAW_RS19965	COG0840	transmembrane signaling receptor activity
XCAW_RS19970	COG0405	Gamma-glutamyltransferase
XCAW_RS19975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XCAW_RS19995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XCAW_RS20000	COG0473	3-isopropylmalate dehydrogenase activity
XCAW_RS20005	COG0066	3-isopropylmalate dehydratase activity
XCAW_RS20010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XCAW_RS20030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XCAW_RS20035	COG1538	Outer membrane efflux protein
XCAW_RS20040	COG1519	Transferase
XCAW_RS20045	COG1560	Kdo2-lipid A biosynthetic process
XCAW_RS20070	COG0280	phosphate acetyltransferase
XCAW_RS20070	COG0281	malic enzyme
XCAW_RS20075	COG1301	dicarboxylic acid transport
XCAW_RS20100	COG0583	DNA-binding transcription factor activity
XCAW_RS20105	COG0667	Aldo Keto reductase
XCAW_RS20120	COG2197	response regulator
XCAW_RS20130	COG0642	Histidine kinase
XCAW_RS20145	COG2851	Citrate transporter
XCAW_RS20150	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS20155	COG1609	Transcriptional regulator
XCAW_RS20160	COG2211	Major facilitator Superfamily
XCAW_RS20185	COG1162	GTPase activity
XCAW_RS20205	COG4773	Receptor
XCAW_RS20210	COG0726	polysaccharide deacetylase
XCAW_RS20215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XCAW_RS20230	COG2963	transposase activity
XCAW_RS20235	COG2801	Transposase and inactivated derivatives
XCAW_RS20250	COG1307	EDD domain protein, DegV family
XCAW_RS20255	COG0242	peptide deformylase activity
XCAW_RS20280	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XCAW_RS20285	COG1215	transferase activity, transferring glycosyl groups
XCAW_RS20290	COG1215	transferase activity, transferring glycosyl groups
XCAW_RS20305	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XCAW_RS20360	COG2188	Transcriptional regulator
XCAW_RS20385	COG3166	PFAM Fimbrial assembly family protein
XCAW_RS20390	COG3156	type II secretion system protein K
XCAW_RS20395	COG4795	General secretion pathway protein
XCAW_RS20400	COG2165	general secretion pathway protein
XCAW_RS20405	COG4970	Tfp pilus assembly protein FimT
XCAW_RS20410	COG2165	general secretion pathway protein
XCAW_RS20415	COG1459	type II secretion system
XCAW_RS20420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XCAW_RS20425	COG1404	Belongs to the peptidase S8 family
XCAW_RS20430	COG5295	Hep Hag repeat protein
XCAW_RS20435	COG1404	Belongs to the peptidase S8 family
XCAW_RS20440	COG5295	Hep Hag repeat protein
XCAW_RS20450	COG0047	phosphoribosylformylglycinamidine synthase activity
XCAW_RS20450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XCAW_RS20455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XCAW_RS20460	COG4974	Belongs to the 'phage' integrase family
XCAW_RS20475	COG0795	lipopolysaccharide-transporting ATPase activity
XCAW_RS20485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XCAW_RS20500	COG0525	valine-tRNA ligase activity
XCAW_RS20530	COG1183	phosphatidylcholine synthase activity
XCAW_RS20540	COG0442	prolyl-tRNA aminoacylation
XCAW_RS20555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XCAW_RS20560	COG1127	ABC transporter
XCAW_RS20565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XCAW_RS20565	COG3218	ABC-type transport auxiliary lipoprotein component
XCAW_RS20600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XCAW_RS20605	COG0662	Cupin 2, conserved barrel domain protein
XCAW_RS20605	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XCAW_RS20635	COG2086	electron transfer activity
XCAW_RS20650	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XCAW_RS20650	COG0546	phosphoglycolate phosphatase activity
XCAW_RS20655	COG0277	FAD linked oxidase domain protein
XCAW_RS20660	COG0300	oxidoreductase activity
XCAW_RS20670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCAW_RS20690	COG2226	methyltransferase
XCAW_RS20700	COG3754	Rhamnan synthesis protein F
XCAW_RS20705	COG1216	Glycosyl transferase, family 2
XCAW_RS20705	COG0438	transferase activity, transferring glycosyl groups
XCAW_RS20710	COG0110	maltose O-acetyltransferase activity
XCAW_RS20725	COG0626	cystathionine gamma-synthase activity
XCAW_RS20755	COG0625	glutathione transferase activity
XCAW_RS20765	COG0513	Belongs to the DEAD box helicase family
XCAW_RS20775	COG4206	TonB-dependent receptor
XCAW_RS20780	COG0720	synthase
XCAW_RS20790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XCAW_RS20800	COG1956	GAF domain-containing protein
XCAW_RS20810	COG2819	hydrolase of the alpha beta superfamily
XCAW_RS20825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XCAW_RS20830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XCAW_RS20845	COG0339	signal peptide processing
XCAW_RS20895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XCAW_RS20900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCAW_RS20905	COG1136	(ABC) transporter
XCAW_RS20905	COG4591	ABC-type transport system involved in lipoprotein release permease component
XCAW_RS20910	COG0577	efflux transmembrane transporter activity
XCAW_RS20915	COG0577	efflux transmembrane transporter activity
XCAW_RS20930	COG4191	Histidine kinase
XCAW_RS20935	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XCAW_RS20950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XCAW_RS20955	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XCAW_RS20960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XCAW_RS20965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XCAW_RS20970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XCAW_RS20975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XCAW_RS20985	COG0356	it plays a direct role in the translocation of protons across the membrane
XCAW_RS21005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XCAW_RS21060	COG2011	ABC-type metal ion transport system permease component
XCAW_RS21065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XCAW_RS21070	COG0697	spore germination
XCAW_RS21075	COG1666	GTP binding
XCAW_RS21085	COG5002	protein histidine kinase activity
XCAW_RS21085	COG2198	Histidine kinase
XCAW_RS21085	COG0784	Response regulator, receiver
XCAW_RS21110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XCAW_RS21115	COG1187	pseudouridine synthase activity
XCAW_RS21120	COG2813	Specifically methylates the guanine in position
XCAW_RS21140	COG2202	Pas domain
XCAW_RS21140	COG2205	protein histidine kinase activity
XCAW_RS21160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XCAW_RS21165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCAW_RS21220	COG0842	Transport permease protein
XCAW_RS21225	COG1131	(ABC) transporter
XCAW_RS21230	COG0025	NhaP-type Na H and K H
XCAW_RS21235	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XCAW_RS21240	COG1573	uracil-dna glycosylase
XCAW_RS21250	COG3384	dioxygenase
XCAW_RS21260	COG0583	DNA-binding transcription factor activity
XCAW_RS21270	COG0667	Aldo Keto reductase
XCAW_RS21280	COG3590	peptidase
XCAW_RS21300	COG0531	amino acid
XCAW_RS21315	COG2972	Histidine kinase
XCAW_RS21330	COG3685	Protein conserved in bacteria
XCAW_RS21335	COG3546	catalase activity
XCAW_RS21380	COG1271	oxidase subunit
XCAW_RS21385	COG1294	oxidase, subunit
XCAW_RS21400	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS21405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XCAW_RS21425	COG1132	(ABC) transporter
XCAW_RS21440	COG1063	alcohol dehydrogenase
XCAW_RS21515	COG0251	oxidation-reduction process
XCAW_RS21530	COG0840	transmembrane signaling receptor activity
XCAW_RS21550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XCAW_RS21590	COG0024	Methionine aminopeptidase
XCAW_RS21610	COG2963	transposase activity
XCAW_RS21615	COG2801	Transposase and inactivated derivatives
XCAW_RS21630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XCAW_RS21660	COG4695	Portal protein
XCAW_RS21705	COG3179	chitinase
XCAW_RS21885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XCAW_RS21890	COG1490	D-aminoacyl-tRNA deacylase activity
XCAW_RS21895	COG1560	Kdo2-lipid A biosynthetic process
XCAW_RS21945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XCAW_RS21945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XCAW_RS21950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XCAW_RS21955	COG0242	peptide deformylase activity
XCAW_RS21960	COG1652	LysM domain
XCAW_RS21965	COG0758	DNA mediated transformation
XCAW_RS21985	COG1754	DNA topoisomerase type I activity
XCAW_RS21985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XCAW_RS21990	COG0009	L-threonylcarbamoyladenylate synthase
XCAW_RS22005	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_RS22015	COG0616	signal peptide processing
XCAW_RS22020	COG0534	Mate efflux family protein
XCAW_RS22040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XCAW_RS22045	COG0625	glutathione transferase activity
XCAW_RS22060	COG1252	NADH dehydrogenase
XCAW_RS22065	COG2860	membrane
XCAW_RS22070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XCAW_RS22075	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XCAW_RS22080	COG2201	protein-glutamate methylesterase activity
XCAW_RS22085	COG2177	Part of the ABC transporter FtsEX involved in
XCAW_RS22090	COG2884	Cell division ATP-binding protein ftsE
XCAW_RS22095	COG0513	Belongs to the DEAD box helicase family
XCAW_RS22100	COG3118	belongs to the thioredoxin family
XCAW_RS22105	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XCAW_RS22110	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XCAW_RS22115	COG0583	DNA-binding transcription factor activity
XCAW_RS22160	COG1518	maintenance of DNA repeat elements
XCAW_RS22185	COG1652	LysM domain
XCAW_RS22190	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XCAW_RS22190	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XCAW_RS22195	COG1473	amidohydrolase
XCAW_RS22200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCAW_RS22205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCAW_RS22215	COG5383	Protein conserved in bacteria
XCAW_RS22255	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XCAW_RS22260	COG3023	N-Acetylmuramoyl-L-alanine amidase
XCAW_RS22270	COG4948	Mandelate Racemase Muconate Lactonizing
XCAW_RS22280	COG0531	amino acid
XCAW_RS22295	COG4682	membrane
XCAW_RS22300	COG2133	pyrroloquinoline quinone binding
XCAW_RS22310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XCAW_RS22315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XCAW_RS22325	COG1610	YqeY-like protein
XCAW_RS22330	COG1295	ribonuclease BN
XCAW_RS22335	COG0358	DNA primase activity
XCAW_RS22350	COG0109	protoheme IX farnesyltransferase activity
XCAW_RS22380	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XCAW_RS22395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XCAW_RS22435	COG3135	benzoate transporter
XCAW_RS22455	COG0676	glucose-6-phosphate 1-epimerase activity
XCAW_RS22465	COG3012	SEC-C Motif Domain Protein
XCAW_RS22470	COG0730	response to heat
XCAW_RS22490	COG0302	gtp cyclohydrolase
XCAW_RS22505	COG1566	PFAM secretion protein HlyD family protein
XCAW_RS22515	COG1289	transmembrane transporter activity
XCAW_RS22520	COG0477	Major facilitator Superfamily
XCAW_RS22530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCAW_RS22550	COG4691	Plasmid stability protein
XCAW_RS22555	COG1487	ribonuclease activity
XCAW_RS22580	COG0564	pseudouridine synthase activity
XCAW_RS22590	COG2963	transposase activity
XCAW_RS22615	COG0439	Biotin carboxylase
XCAW_RS22655	COG1074	ATP-dependent DNA helicase activity
XCAW_RS22660	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XCAW_RS22675	COG1127	ABC transporter
XCAW_RS22680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XCAW_RS22685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XCAW_RS22700	COG2853	Lipoprotein
XCAW_RS22710	COG0386	Belongs to the glutathione peroxidase family
XCAW_RS22720	COG1322	Protein conserved in bacteria
XCAW_RS22725	COG0604	alcohol dehydrogenase
XCAW_RS22745	COG0625	glutathione transferase activity
XCAW_RS22755	COG0531	amino acid
XCAW_RS22760	COG3537	Alpha-1,2-mannosidase
XCAW_RS22770	COG3706	GGDEF domain
XCAW_RS22775	COG3835	regulator
XCAW_RS22780	COG1929	Belongs to the glycerate kinase type-1 family
XCAW_RS22785	COG2271	Major facilitator Superfamily
XCAW_RS22800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XCAW_RS22805	COG0861	Integral membrane protein TerC family
XCAW_RS22815	COG0584	glycerophosphoryl diester phosphodiesterase
XCAW_RS22830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XCAW_RS22835	COG0726	polysaccharide deacetylase
XCAW_RS22840	COG0706	membrane insertase activity
XCAW_RS22845	COG0594	ribonuclease P activity
XCAW_RS22885	COG0187	DNA topoisomerase II activity