locus-tag	class	description
AMD12_RS00045	COG0187	DNA topoisomerase II activity
AMD12_RS00085	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMD12_RS00275	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD12_RS00335	COG0069	glutamate synthase activity
AMD12_RS00335	COG0067	glutamate synthase
AMD12_RS00335	COG0070	glutamate synthase
AMD12_RS00345	COG0067	glutamate synthase
AMD12_RS00345	COG0069	glutamate synthase activity
AMD12_RS00345	COG0070	glutamate synthase
AMD12_RS00470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AMD12_RS00480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMD12_RS00485	COG0187	DNA topoisomerase II activity
AMD12_RS00495	COG0501	Belongs to the peptidase M48B family
AMD12_RS00525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMD12_RS00535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD12_RS00580	COG0793	Belongs to the peptidase S41A family
AMD12_RS00585	COG4942	peptidase
AMD12_RS00595	COG2234	aminopeptidase activity
AMD12_RS00605	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD12_RS00610	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD12_RS00615	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD12_RS00620	COG1064	alcohol dehydrogenase
AMD12_RS00625	COG0493	'glutamate synthase
AMD12_RS00630	COG0070	glutamate synthase
AMD12_RS00630	COG0069	glutamate synthase activity
AMD12_RS00630	COG0067	glutamate synthase
AMD12_RS00675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AMD12_RS00690	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AMD12_RS00695	COG0297	glycogen (starch) synthase activity
AMD12_RS00695	COG0438	transferase activity, transferring glycosyl groups
AMD12_RS00715	COG0367	asparagine synthase
AMD12_RS00745	COG1132	(ABC) transporter
AMD12_RS00775	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AMD12_RS00855	COG1205	dead DEAH box helicase
AMD12_RS00855	COG1111	helicase
AMD12_RS00860	COG1272	protein, Hemolysin III
AMD12_RS00875	COG0300	oxidoreductase activity
AMD12_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS00900	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMD12_RS00960	COG3237	CsbD-like
AMD12_RS01010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD12_RS01020	COG0477	Major facilitator Superfamily
AMD12_RS01060	COG0714	Associated with various cellular activities
AMD12_RS01090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AMD12_RS01100	COG4772	TonB-dependent receptor
AMD12_RS01110	COG0662	Cupin 2, conserved barrel domain protein
AMD12_RS01115	COG1012	belongs to the aldehyde dehydrogenase family
AMD12_RS01140	COG1304	FMN binding
AMD12_RS01150	COG4585	Histidine kinase
AMD12_RS01155	COG2197	response regulator
AMD12_RS01175	COG3710	Transcriptional regulator
AMD12_RS01180	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMD12_RS01250	COG2801	Transposase and inactivated derivatives
AMD12_RS01255	COG0366	Alpha amylase catalytic
AMD12_RS01260	COG0366	Alpha amylase catalytic
AMD12_RS01265	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMD12_RS01285	COG2755	lipolytic protein G-D-S-L family
AMD12_RS01285	COG0657	acetylesterase activity
AMD12_RS01295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMD12_RS01310	COG3507	Belongs to the glycosyl hydrolase 43 family
AMD12_RS01315	COG1609	Transcriptional regulator
AMD12_RS01320	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AMD12_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS01335	COG2755	lipolytic protein G-D-S-L family
AMD12_RS01350	COG3186	Phenylalanine-4-hydroxylase
AMD12_RS01355	COG1522	sequence-specific DNA binding
AMD12_RS01365	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMD12_RS01375	COG1119	ATPase activity
AMD12_RS01390	COG1125	glycine betaine transport
AMD12_RS01405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMD12_RS01425	COG1396	sequence-specific DNA binding
AMD12_RS01450	COG0489	protein tyrosine kinase activity
AMD12_RS01455	COG2062	phosphohistidine phosphatase, SixA
AMD12_RS01465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD12_RS01510	COG1968	undecaprenyl-diphosphatase activity
AMD12_RS01515	COG0174	glutamine synthetase
AMD12_RS01520	COG0347	Belongs to the P(II) protein family
AMD12_RS01525	COG0004	ammonium transporteR
AMD12_RS01530	COG3852	Histidine kinase
AMD12_RS01535	COG2204	response regulator
AMD12_RS01540	COG2032	superoxide dismutase activity
AMD12_RS01545	COG2032	superoxide dismutase activity
AMD12_RS01550	COG0346	lactoylglutathione lyase activity
AMD12_RS01560	COG0183	Belongs to the thiolase family
AMD12_RS01595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AMD12_RS01600	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AMD12_RS01605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMD12_RS01615	COG0028	Belongs to the TPP enzyme family
AMD12_RS01620	COG2205	protein histidine kinase activity
AMD12_RS01645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AMD12_RS01660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD12_RS01670	COG0596	Alpha beta hydrolase
AMD12_RS01675	COG0727	PFAM Uncharacterised protein family (UPF0153)
AMD12_RS01680	COG0318	PFAM AMP-dependent synthetase and ligase
AMD12_RS01685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD12_RS01700	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMD12_RS01710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMD12_RS01720	COG0564	pseudouridine synthase activity
AMD12_RS01745	COG0339	signal peptide processing
AMD12_RS01775	COG0475	glutathione-regulated potassium exporter activity
AMD12_RS01780	COG0583	DNA-binding transcription factor activity
AMD12_RS01785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AMD12_RS01790	COG2224	Isocitrate lyase
AMD12_RS01820	COG4770	biotin carboxylase activity
AMD12_RS01825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMD12_RS01830	COG1960	acyl-CoA dehydrogenase activity
AMD12_RS01885	COG0523	cobalamin synthesis protein
AMD12_RS01900	COG0697	spore germination
AMD12_RS01910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AMD12_RS01915	COG1846	Transcriptional regulator
AMD12_RS01920	COG1764	response to oxidative stress
AMD12_RS01950	COG2130	NADP-dependent
AMD12_RS01965	COG1187	pseudouridine synthase activity
AMD12_RS01980	COG1643	Atp-dependent helicase
AMD12_RS01990	COG4807	Protein conserved in bacteria
AMD12_RS01995	COG2351	hydroxyisourate hydrolase activity
AMD12_RS02000	COG2072	flavoprotein involved in K transport
AMD12_RS02020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AMD12_RS02055	COG1957	nucleoside hydrolase
AMD12_RS02065	COG2252	PERMEase
AMD12_RS02090	COG0084	hydrolase, TatD family'
AMD12_RS02105	COG0583	DNA-binding transcription factor activity
AMD12_RS02110	COG2814	Major facilitator Superfamily
AMD12_RS02125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMD12_RS02130	COG1902	pentaerythritol trinitrate reductase activity
AMD12_RS02150	COG0745	RESPONSE REGULATOR receiver
AMD12_RS02155	COG2205	protein histidine kinase activity
AMD12_RS02160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD12_RS02180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMD12_RS02185	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMD12_RS02190	COG0583	DNA-binding transcription factor activity
AMD12_RS02220	COG0702	epimerase
AMD12_RS02225	COG1733	regulation of RNA biosynthetic process
AMD12_RS02250	COG2801	Transposase and inactivated derivatives
AMD12_RS02265	COG0129	dihydroxy-acid dehydratase activity
AMD12_RS02285	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AMD12_RS02340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMD12_RS02345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AMD12_RS02370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMD12_RS02375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMD12_RS02385	COG3485	protocatechuate 3,4-dioxygenase
AMD12_RS02390	COG3485	protocatechuate 3,4-dioxygenase
AMD12_RS02400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD12_RS02405	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMD12_RS02415	COG1414	Transcriptional regulator
AMD12_RS02425	COG0657	acetylesterase activity
AMD12_RS02435	COG0445	tRNA wobble uridine modification
AMD12_RS02445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMD12_RS02475	COG2267	carboxylic ester hydrolase activity
AMD12_RS02485	COG0156	8-amino-7-oxononanoate synthase activity
AMD12_RS02490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AMD12_RS02495	COG1040	competence protein
AMD12_RS02500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMD12_RS02575	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AMD12_RS02645	COG1511	domain protein
AMD12_RS02645	COG3264	Mechanosensitive ion channel
AMD12_RS02650	COG1368	sulfuric ester hydrolase activity
AMD12_RS02655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMD12_RS02660	COG2354	Protein conserved in bacteria
AMD12_RS02670	COG0297	glycogen (starch) synthase activity
AMD12_RS02675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMD12_RS02680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMD12_RS02705	COG0702	epimerase
AMD12_RS02710	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS02745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD12_RS02750	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS02760	COG0513	Belongs to the DEAD box helicase family
AMD12_RS02780	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMD12_RS02790	COG3483	tryptophan 2,3-dioxygenase activity
AMD12_RS02795	COG3104	oligopeptide transport
AMD12_RS02815	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AMD12_RS02830	COG1320	monovalent cation:proton antiporter activity
AMD12_RS02835	COG2212	antiporter activity
AMD12_RS02845	COG0651	ATP synthesis coupled electron transport
AMD12_RS02850	COG1006	Multisubunit Na H antiporter MnhC subunit
AMD12_RS02855	COG2111	Na H antiporter
AMD12_RS02855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMD12_RS02875	COG3179	chitinase
AMD12_RS02895	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMD12_RS02900	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AMD12_RS02915	COG0456	acetyltransferase
AMD12_RS02920	COG1597	lipid kinase activity
AMD12_RS02945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMD12_RS02950	COG0134	indole-3-glycerol-phosphate synthase activity
AMD12_RS02960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD12_RS02965	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMD12_RS02975	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AMD12_RS02985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMD12_RS03000	COG1051	belongs to the nudix hydrolase family
AMD12_RS03040	COG0316	Belongs to the HesB IscA family
AMD12_RS03065	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMD12_RS03085	COG2814	Major facilitator Superfamily
AMD12_RS03090	COG0583	DNA-binding transcription factor activity
AMD12_RS03095	COG2814	Major facilitator Superfamily
AMD12_RS03100	COG1289	transmembrane transporter activity
AMD12_RS03110	COG0151	Belongs to the GarS family
AMD12_RS03120	COG0138	bifunctional purine biosynthesis protein purh
AMD12_RS03125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD12_RS03130	COG2267	carboxylic ester hydrolase activity
AMD12_RS03135	COG2453	phosphatase
AMD12_RS03135	COG0671	phosphoesterase, PA-phosphatase related
AMD12_RS03160	COG4589	Belongs to the CDS family
AMD12_RS03165	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AMD12_RS03190	COG2264	protein methyltransferase activity
AMD12_RS03205	COG0439	Biotin carboxylase
AMD12_RS03215	COG0511	ligase activity, forming carbon-carbon bonds
AMD12_RS03220	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMD12_RS03230	COG1324	tolerance protein
AMD12_RS03255	COG0300	oxidoreductase activity
AMD12_RS03260	COG2356	endonuclease I
AMD12_RS03270	COG0459	protein refolding
AMD12_RS03285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AMD12_RS03300	COG3386	PFAM SMP-30 Gluconolaconase
AMD12_RS03310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMD12_RS03315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AMD12_RS03335	COG0778	Nitroreductase
AMD12_RS03340	COG2353	YceI-like domain
AMD12_RS03370	COG3052	prosthetic group binding
AMD12_RS03395	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMD12_RS03405	COG1802	Transcriptional regulator
AMD12_RS03450	COG2801	Transposase and inactivated derivatives
AMD12_RS03460	COG4221	oxidoreductase activity
AMD12_RS03475	COG4221	oxidoreductase activity
AMD12_RS03485	COG0435	Glutathione S-transferase
AMD12_RS03510	COG2409	Drug exporters of the RND superfamily
AMD12_RS03515	COG1506	peptidase
AMD12_RS03515	COG0823	Involved in the tonB-independent uptake of proteins
AMD12_RS03555	COG0697	spore germination
AMD12_RS03570	COG1113	amino acid transport
AMD12_RS03590	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AMD12_RS03625	COG5001	Diguanylate cyclase
AMD12_RS03630	COG0840	transmembrane signaling receptor activity
AMD12_RS03635	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD12_RS03635	COG5297	Belongs to the glycosyl hydrolase family 6
AMD12_RS03640	COG0659	secondary active sulfate transmembrane transporter activity
AMD12_RS03665	COG2943	transferase activity, transferring hexosyl groups
AMD12_RS03675	COG3275	phosphorelay sensor kinase activity
AMD12_RS03685	COG0181	hydroxymethylbilane synthase activity
AMD12_RS03710	COG1505	serine-type exopeptidase activity
AMD12_RS03715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMD12_RS03720	COG0436	Aminotransferase
AMD12_RS03730	COG2832	Protein of unknown function (DUF454)
AMD12_RS03740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AMD12_RS03750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AMD12_RS03755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AMD12_RS03760	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AMD12_RS03785	COG2226	methyltransferase
AMD12_RS03790	COG5001	Diguanylate cyclase
AMD12_RS03790	COG3300	MHYT domain
AMD12_RS03795	COG0308	aminopeptidase N
AMD12_RS03845	COG3284	Transcriptional regulator
AMD12_RS03850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD12_RS03855	COG1077	Cell shape determining protein MreB Mrl
AMD12_RS03860	COG1792	Involved in formation and maintenance of cell shape
AMD12_RS03875	COG0772	Belongs to the SEDS family
AMD12_RS03885	COG2951	lytic endotransglycosylase activity
AMD12_RS03890	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AMD12_RS03900	COG1686	Belongs to the peptidase S11 family
AMD12_RS03910	COG2921	Belongs to the UPF0250 family
AMD12_RS03915	COG0321	lipoyl(octanoyl) transferase activity
AMD12_RS03920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMD12_RS03935	COG0583	DNA-binding transcription factor activity
AMD12_RS03945	COG1051	belongs to the nudix hydrolase family
AMD12_RS03945	COG1056	cytidyltransferase-related domain
AMD12_RS03980	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AMD12_RS03985	COG0673	inositol 2-dehydrogenase activity
AMD12_RS03990	COG2823	Periplasmic or secreted lipoprotein
AMD12_RS03995	COG4251	negative regulation of phosphorylation
AMD12_RS04000	COG0784	Response regulator, receiver
AMD12_RS04005	COG4191	Histidine kinase
AMD12_RS04010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AMD12_RS04065	COG1459	type II secretion system
AMD12_RS04130	COG2188	Transcriptional regulator
AMD12_RS04140	COG1609	Transcriptional regulator
AMD12_RS04145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMD12_RS04150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AMD12_RS04160	COG0617	tRNA 3'-terminal CCA addition
AMD12_RS04165	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AMD12_RS04170	COG1012	belongs to the aldehyde dehydrogenase family
AMD12_RS04175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AMD12_RS04185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMD12_RS04200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AMD12_RS04205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AMD12_RS04220	COG2205	protein histidine kinase activity
AMD12_RS04250	COG3791	Glutathione-dependent formaldehyde-activating
AMD12_RS04265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMD12_RS04275	COG0697	spore germination
AMD12_RS04285	COG0488	(ABC) transporter
AMD12_RS04295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMD12_RS04300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMD12_RS04310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMD12_RS04310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMD12_RS04330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMD12_RS04335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMD12_RS04340	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AMD12_RS04360	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AMD12_RS04365	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AMD12_RS04370	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AMD12_RS04375	COG2205	protein histidine kinase activity
AMD12_RS04380	COG0745	RESPONSE REGULATOR receiver
AMD12_RS04395	COG0277	FAD linked oxidase domain protein
AMD12_RS04400	COG1988	membrane-bound metal-dependent
AMD12_RS04405	COG0792	nuclease activity
AMD12_RS04435	COG0275	rRNA processing
AMD12_RS04440	COG3116	cell division
AMD12_RS04450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMD12_RS04455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMD12_RS04460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMD12_RS04470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMD12_RS04475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMD12_RS04480	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMD12_RS04485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AMD12_RS04500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AMD12_RS04510	COG0739	heme binding
AMD12_RS04515	COG0653	protein targeting
AMD12_RS04520	COG0494	nUDIX hydrolase
AMD12_RS04530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMD12_RS04540	COG0604	alcohol dehydrogenase
AMD12_RS04540	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS04540	COG3321	synthase
AMD12_RS04560	COG0366	Alpha amylase catalytic
AMD12_RS04590	COG2226	methyltransferase
AMD12_RS04595	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AMD12_RS04605	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AMD12_RS04640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMD12_RS04650	COG4106	trans-aconitate 2-methyltransferase activity
AMD12_RS04655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMD12_RS04665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD12_RS04670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AMD12_RS04675	COG0667	Aldo Keto reductase
AMD12_RS04685	COG4771	TonB-dependent receptor
AMD12_RS04705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD12_RS04710	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AMD12_RS04720	COG2175	clavaminate synthase activity
AMD12_RS04730	COG4181	ATPase activity
AMD12_RS04745	COG0642	Histidine kinase
AMD12_RS04755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AMD12_RS04775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMD12_RS04780	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AMD12_RS04795	COG3829	transcription factor binding
AMD12_RS04805	COG1116	anion transmembrane transporter activity
AMD12_RS04810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD12_RS04820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD12_RS04825	COG0431	NADPH-dependent FMN reductase
AMD12_RS04850	COG0747	negative chemotaxis
AMD12_RS04860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMD12_RS04870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AMD12_RS04875	COG2967	ApaG domain
AMD12_RS04880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMD12_RS04885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AMD12_RS04890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD12_RS04895	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AMD12_RS04905	COG0123	including yeast histone deacetylase and acetoin utilization protein
AMD12_RS04910	COG2096	Adenosyltransferase
AMD12_RS04920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD12_RS04925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD12_RS04955	COG3384	dioxygenase
AMD12_RS04960	COG0583	DNA-binding transcription factor activity
AMD12_RS04975	COG1024	Enoyl-CoA hydratase
AMD12_RS04995	COG3386	PFAM SMP-30 Gluconolaconase
AMD12_RS05005	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AMD12_RS05030	COG0697	spore germination
AMD12_RS05040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD12_RS05060	COG2205	protein histidine kinase activity
AMD12_RS05060	COG0784	Response regulator, receiver
AMD12_RS05060	COG5002	protein histidine kinase activity
AMD12_RS05065	COG2197	response regulator
AMD12_RS05075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMD12_RS05085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMD12_RS05090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD12_RS05095	COG0583	DNA-binding transcription factor activity
AMD12_RS05100	COG3634	alkyl hydroperoxide reductase activity
AMD12_RS05110	COG2890	protein-(glutamine-N5) methyltransferase activity
AMD12_RS05130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD12_RS05130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD12_RS05160	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AMD12_RS05190	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AMD12_RS05205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMD12_RS05210	COG1404	Belongs to the peptidase S8 family
AMD12_RS05215	COG1404	Belongs to the peptidase S8 family
AMD12_RS05220	COG1404	Belongs to the peptidase S8 family
AMD12_RS05225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMD12_RS05250	COG1295	ribonuclease BN
AMD12_RS05255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD12_RS05260	COG1254	Belongs to the acylphosphatase family
AMD12_RS05275	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMD12_RS05285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMD12_RS05290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AMD12_RS05300	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AMD12_RS05305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AMD12_RS05315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AMD12_RS05320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AMD12_RS05325	COG0193	aminoacyl-tRNA hydrolase activity
AMD12_RS05330	COG0012	GTP binding
AMD12_RS05350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMD12_RS05365	COG0250	Participates in transcription elongation, termination and antitermination
AMD12_RS05370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMD12_RS05375	COG0081	regulation of translation
AMD12_RS05380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMD12_RS05385	COG0222	ribosome binding
AMD12_RS05390	COG0085	RNA polymerase activity
AMD12_RS05395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMD12_RS05400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMD12_RS05405	COG0049	tRNA binding
AMD12_RS05410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMD12_RS05415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMD12_RS05420	COG0051	transcription antitermination factor activity, RNA binding
AMD12_RS05425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMD12_RS05430	COG0088	Forms part of the polypeptide exit tunnel
AMD12_RS05435	COG0089	rRNA binding
AMD12_RS05440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMD12_RS05445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMD12_RS05455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMD12_RS05460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AMD12_RS05465	COG0255	Belongs to the universal ribosomal protein uL29 family
AMD12_RS05470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMD12_RS05480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AMD12_RS05485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMD12_RS05495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMD12_RS05500	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMD12_RS05505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AMD12_RS05515	COG1841	ribosomal large subunit assembly
AMD12_RS05520	COG0200	Binds to the 23S rRNA
AMD12_RS05525	COG0201	protein transport
AMD12_RS05550	COG0203	ribosomal protein L17
AMD12_RS05555	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AMD12_RS05570	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AMD12_RS05580	COG0154	amidase activity
AMD12_RS05590	COG1217	gtp-binding protein TYPA
AMD12_RS05595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMD12_RS05600	COG0039	L-malate dehydrogenase activity
AMD12_RS05605	COG0625	glutathione transferase activity
AMD12_RS05615	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMD12_RS05615	COG1902	pentaerythritol trinitrate reductase activity
AMD12_RS05620	COG0604	alcohol dehydrogenase
AMD12_RS05645	COG0156	8-amino-7-oxononanoate synthase activity
AMD12_RS05650	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AMD12_RS05655	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AMD12_RS05660	COG4208	sulfate ABC transporter
AMD12_RS05665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AMD12_RS05675	COG1063	alcohol dehydrogenase
AMD12_RS05705	COG0406	alpha-ribazole phosphatase activity
AMD12_RS05710	COG0285	dihydrofolate synthase activity
AMD12_RS05730	COG2833	Protein of unknown function (DUF455)
AMD12_RS05740	COG3291	Pkd domain containing protein
AMD12_RS05750	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD12_RS05755	COG0671	phosphoesterase, PA-phosphatase related
AMD12_RS05760	COG0438	transferase activity, transferring glycosyl groups
AMD12_RS05770	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AMD12_RS05785	COG4783	chaperone-mediated protein folding
AMD12_RS05800	COG0473	3-isopropylmalate dehydrogenase activity
AMD12_RS05930	COG2801	Transposase and inactivated derivatives
AMD12_RS05945	COG3852	Histidine kinase
AMD12_RS05955	COG0544	peptidyl-prolyl cis-trans isomerase activity
AMD12_RS05965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMD12_RS05995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD12_RS06005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD12_RS06015	COG0328	RNA-DNA hybrid ribonuclease activity
AMD12_RS06020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD12_RS06025	COG0631	protein serine/threonine phosphatase activity
AMD12_RS06040	COG0859	PFAM glycosyl transferase family 9
AMD12_RS06045	COG3642	lipopolysaccharide core region biosynthetic process
AMD12_RS06050	COG1234	tRNA 3'-trailer cleavage
AMD12_RS06055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMD12_RS06065	COG0315	cyclic pyranopterin monophosphate synthase activity
AMD12_RS06070	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AMD12_RS06075	COG0314	molybdopterin synthase activity
AMD12_RS06130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMD12_RS06135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMD12_RS06140	COG0537	adenosine 5'-monophosphoramidase activity
AMD12_RS06160	COG0714	Associated with various cellular activities
AMD12_RS06180	COG0424	maF-like protein
AMD12_RS06185	COG1399	metal-binding, possibly nucleic acid-binding protein
AMD12_RS06190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMD12_RS06195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD12_RS06210	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS06225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMD12_RS06230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMD12_RS06255	COG3829	transcription factor binding
AMD12_RS06275	COG3609	addiction module antidote protein, CC2985 family
AMD12_RS06295	COG2373	Large extracellular alpha-helical protein
AMD12_RS06310	COG4953	penicillin-binding protein 1C
AMD12_RS06320	COG0678	peroxiredoxin activity
AMD12_RS06340	COG0330	HflC and HflK could
AMD12_RS06345	COG0330	HflC and HflK could
AMD12_RS06355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMD12_RS06360	COG0308	aminopeptidase N
AMD12_RS06370	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS06375	COG1309	transcriptional regulator
AMD12_RS06445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMD12_RS06455	COG3387	PFAM Glycoside hydrolase 15-related
AMD12_RS06460	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS06465	COG3537	Alpha-1,2-mannosidase
AMD12_RS06485	COG0492	ferredoxin-NADP+ reductase activity
AMD12_RS06510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMD12_RS06515	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMD12_RS06520	COG2080	2 iron, 2 sulfur cluster binding
AMD12_RS06555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMD12_RS06570	COG0587	DNA-directed DNA polymerase activity
AMD12_RS06585	COG1297	OPT oligopeptide transporter protein
AMD12_RS06600	COG1506	peptidase
AMD12_RS06600	COG0823	Involved in the tonB-independent uptake of proteins
AMD12_RS06615	COG2207	Transcriptional regulator
AMD12_RS06615	COG1917	Cupin 2, conserved barrel domain protein
AMD12_RS06630	COG0753	catalase activity
AMD12_RS06635	COG0656	L-ascorbic acid biosynthetic process
AMD12_RS06645	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMD12_RS06645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMD12_RS06650	COG2814	Major facilitator Superfamily
AMD12_RS06665	COG2194	sulfuric ester hydrolase activity
AMD12_RS06680	COG0745	RESPONSE REGULATOR receiver
AMD12_RS06685	COG0642	Histidine kinase
AMD12_RS06695	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AMD12_RS06700	COG2894	cell division
AMD12_RS06705	COG0850	regulation of cytokinetic process
AMD12_RS06720	COG4585	Histidine kinase
AMD12_RS06725	COG2197	response regulator
AMD12_RS06740	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AMD12_RS06765	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AMD12_RS06775	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AMD12_RS06795	COG1946	Acyl-CoA thioesterase
AMD12_RS06810	COG0824	Thioesterase
AMD12_RS06815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMD12_RS06820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMD12_RS06825	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMD12_RS06830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMD12_RS06835	COG0268	Binds directly to 16S ribosomal RNA
AMD12_RS06845	COG0196	riboflavin kinase activity
AMD12_RS06850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMD12_RS06855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMD12_RS06860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMD12_RS06875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMD12_RS06880	COG1845	cytochrome c oxidase, subunit III
AMD12_RS06885	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AMD12_RS06900	COG3152	Membrane
AMD12_RS06910	COG2207	Transcriptional regulator
AMD12_RS06915	COG0326	Molecular chaperone. Has ATPase activity
AMD12_RS06925	COG1366	Belongs to the anti-sigma-factor antagonist family
AMD12_RS06930	COG1366	Belongs to the anti-sigma-factor antagonist family
AMD12_RS06935	COG2172	sigma factor antagonist activity
AMD12_RS06960	COG4771	TonB-dependent receptor
AMD12_RS06970	COG5507	3-demethylubiquinone-9 3-methyltransferase
AMD12_RS06975	COG2205	protein histidine kinase activity
AMD12_RS06985	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AMD12_RS06990	COG3437	response regulator, receiver
AMD12_RS06990	COG4999	Histidine kinase
AMD12_RS06990	COG2205	protein histidine kinase activity
AMD12_RS06990	COG3850	Histidine kinase
AMD12_RS06995	COG0784	Response regulator, receiver
AMD12_RS06995	COG4191	Histidine kinase
AMD12_RS07025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMD12_RS07030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMD12_RS07040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMD12_RS07045	COG0228	four-way junction DNA binding
AMD12_RS07050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AMD12_RS07055	COG0336	Belongs to the RNA methyltransferase TrmD family
AMD12_RS07060	COG0335	large ribosomal subunit rRNA binding
AMD12_RS07090	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMD12_RS07100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AMD12_RS07110	COG3209	COG3209 Rhs family protein
AMD12_RS07130	COG3250	beta-galactosidase activity
AMD12_RS07135	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AMD12_RS07155	COG1960	acyl-CoA dehydrogenase activity
AMD12_RS07160	COG1024	Enoyl-CoA hydratase
AMD12_RS07180	COG1024	Enoyl-CoA hydratase
AMD12_RS07180	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD12_RS07195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD12_RS07200	COG0481	GTPase activity
AMD12_RS07215	COG0571	ribonuclease III activity
AMD12_RS07220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMD12_RS07225	COG1381	Involved in DNA repair and RecF pathway recombination
AMD12_RS07235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMD12_RS07240	COG2954	triphosphatase activity
AMD12_RS07245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMD12_RS07250	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AMD12_RS07255	COG3046	protein related to deoxyribodipyrimidine photolyase
AMD12_RS07260	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD12_RS07265	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AMD12_RS07270	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AMD12_RS07275	COG1278	Cold shock
AMD12_RS07280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD12_RS07290	COG1201	RNA secondary structure unwinding
AMD12_RS07295	COG1793	dna ligase
AMD12_RS07305	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AMD12_RS07305	COG1793	dna ligase
AMD12_RS07335	COG0183	Belongs to the thiolase family
AMD12_RS07355	COG1451	nucleotide metabolic process
AMD12_RS07360	COG5487	UPF0391 membrane protein
AMD12_RS07370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AMD12_RS07390	COG1077	Cell shape determining protein MreB Mrl
AMD12_RS07395	COG1047	Peptidyl-prolyl cis-trans
AMD12_RS07405	COG2824	Alkylphosphonate utilization operon protein PhnA
AMD12_RS07410	COG1902	pentaerythritol trinitrate reductase activity
AMD12_RS07415	COG2814	Major facilitator Superfamily
AMD12_RS07450	COG0392	lysyltransferase activity
AMD12_RS07450	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMD12_RS07460	COG0251	oxidation-reduction process
AMD12_RS07465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMD12_RS07480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMD12_RS07505	COG1595	DNA-templated transcription, initiation
AMD12_RS07525	COG2878	Part of a membrane complex involved in electron transport
AMD12_RS07535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD12_RS07535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD12_RS07550	COG1131	(ABC) transporter
AMD12_RS07555	COG0346	lactoylglutathione lyase activity
AMD12_RS07560	COG0833	amino acid
AMD12_RS07565	COG2040	homocysteine
AMD12_RS07575	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AMD12_RS07595	COG1695	Transcriptional regulator
AMD12_RS07615	COG1981	membrane
AMD12_RS07630	COG0825	malonyl-CoA metabolic process
AMD12_RS07640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMD12_RS07645	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD12_RS07650	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD12_RS07655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD12_RS07660	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD12_RS07675	COG0750	zinc metalloprotease
AMD12_RS07680	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMD12_RS07685	COG0575	Belongs to the CDS family
AMD12_RS07690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMD12_RS07695	COG0233	cytoplasmic translational termination
AMD12_RS07700	COG0528	UMP kinase activity
AMD12_RS07710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMD12_RS07715	COG0052	Belongs to the universal ribosomal protein uS2 family
AMD12_RS07755	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AMD12_RS07765	COG1393	Belongs to the ArsC family
AMD12_RS07770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMD12_RS07775	COG0367	asparagine synthase
AMD12_RS07785	COG4774	siderophore transport
AMD12_RS07805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMD12_RS07835	COG1566	PFAM secretion protein HlyD family protein
AMD12_RS07840	COG2814	Major facilitator Superfamily
AMD12_RS07890	COG0339	signal peptide processing
AMD12_RS07895	COG0386	Belongs to the glutathione peroxidase family
AMD12_RS07950	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AMD12_RS07955	COG0084	hydrolase, TatD family'
AMD12_RS07970	COG1960	acyl-CoA dehydrogenase activity
AMD12_RS07990	COG0367	asparagine synthase
AMD12_RS08000	COG0305	Participates in initiation and elongation during chromosome replication
AMD12_RS08005	COG0415	Belongs to the DNA photolyase family
AMD12_RS08015	COG0583	DNA-binding transcription factor activity
AMD12_RS08060	COG3706	GGDEF domain
AMD12_RS08165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMD12_RS08180	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD12_RS08190	COG0497	DNA recombination
AMD12_RS08195	COG1420	regulation of RNA biosynthetic process
AMD12_RS08200	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMD12_RS08205	COG0443	Heat shock 70 kDa protein
AMD12_RS08210	COG0484	heat shock protein binding
AMD12_RS08215	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AMD12_RS08245	COG0583	DNA-binding transcription factor activity
AMD12_RS08250	COG1132	(ABC) transporter
AMD12_RS08285	COG2850	peptidyl-arginine hydroxylation
AMD12_RS08305	COG1253	flavin adenine dinucleotide binding
AMD12_RS08335	COG1131	(ABC) transporter
AMD12_RS08340	COG1725	Transcriptional regulator
AMD12_RS08345	COG0386	Belongs to the glutathione peroxidase family
AMD12_RS08360	COG2900	Belongs to the SlyX family
AMD12_RS08385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD12_RS08395	COG1410	methionine synthase
AMD12_RS08395	COG0646	methionine synthase
AMD12_RS08400	COG1410	methionine synthase
AMD12_RS08400	COG0646	methionine synthase
AMD12_RS08405	COG2226	methyltransferase
AMD12_RS08410	COG1960	acyl-CoA dehydrogenase activity
AMD12_RS08425	COG0557	exoribonuclease II activity
AMD12_RS08435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD12_RS08445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD12_RS08455	COG0704	Plays a role in the regulation of phosphate uptake
AMD12_RS08460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMD12_RS08465	COG0581	inorganic phosphate transmembrane transporter activity
AMD12_RS08470	COG0573	inorganic phosphate transmembrane transporter activity
AMD12_RS08475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AMD12_RS08500	COG0659	secondary active sulfate transmembrane transporter activity
AMD12_RS08505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMD12_RS08515	COG1024	Enoyl-CoA hydratase
AMD12_RS08525	COG0494	nUDIX hydrolase
AMD12_RS08560	COG0488	(ABC) transporter
AMD12_RS08565	COG0116	Belongs to the methyltransferase superfamily
AMD12_RS08565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AMD12_RS08570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMD12_RS08595	COG2925	Exonuclease
AMD12_RS08600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD12_RS08605	COG3844	kynureninase activity
AMD12_RS08615	COG0662	Cupin 2, conserved barrel domain protein
AMD12_RS08620	COG0288	reversible hydration of carbon dioxide
AMD12_RS08680	COG2808	Putative FMN-binding domain
AMD12_RS08700	COG0017	Asparaginyl-tRNA synthetase
AMD12_RS08705	COG0316	Belongs to the HesB IscA family
AMD12_RS08710	COG0360	Binds together with S18 to 16S ribosomal RNA
AMD12_RS08715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMD12_RS08720	COG0359	binds to the 23S rRNA
AMD12_RS08730	COG3115	cell septum assembly
AMD12_RS08740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMD12_RS08745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMD12_RS08750	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AMD12_RS08760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMD12_RS08780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AMD12_RS08790	COG2986	histidine ammonia-lyase
AMD12_RS08795	COG1228	amidohydrolase
AMD12_RS08840	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AMD12_RS08845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AMD12_RS08850	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AMD12_RS08855	COG0077	Prephenate dehydratase
AMD12_RS08855	COG1605	Chorismate mutase
AMD12_RS08860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMD12_RS08875	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMD12_RS08880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMD12_RS08885	COG0583	DNA-binding transcription factor activity
AMD12_RS08920	COG2801	Transposase and inactivated derivatives
AMD12_RS08940	COG0840	transmembrane signaling receptor activity
AMD12_RS08975	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AMD12_RS08980	COG4191	Histidine kinase
AMD12_RS08980	COG0784	Response regulator, receiver
AMD12_RS08995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD12_RS09005	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AMD12_RS09015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMD12_RS09030	COG1595	DNA-templated transcription, initiation
AMD12_RS09085	COG2244	polysaccharide biosynthetic process
AMD12_RS09115	COG2264	protein methyltransferase activity
AMD12_RS09125	COG0438	transferase activity, transferring glycosyl groups
AMD12_RS09140	COG1136	(ABC) transporter
AMD12_RS09150	COG0477	Major facilitator Superfamily
AMD12_RS09155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD12_RS09170	COG1253	flavin adenine dinucleotide binding
AMD12_RS09180	COG0306	phosphate transporter
AMD12_RS09205	COG0504	CTP synthase activity
AMD12_RS09210	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AMD12_RS09220	COG0148	phosphopyruvate hydratase activity
AMD12_RS09225	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AMD12_RS09230	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMD12_RS09235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMD12_RS09240	COG0585	pseudouridine synthase activity
AMD12_RS09245	COG2840	Smr protein MutS2
AMD12_RS09250	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AMD12_RS09255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMD12_RS09260	COG1238	metal cluster binding
AMD12_RS09275	COG1534	Rna-binding protein
AMD12_RS09280	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AMD12_RS09290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMD12_RS09295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMD12_RS09305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMD12_RS09310	COG1546	Belongs to the CinA family
AMD12_RS09320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMD12_RS09325	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMD12_RS09330	COG2137	regulation of response to DNA damage stimulus
AMD12_RS09335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMD12_RS09340	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AMD12_RS09355	COG1741	Belongs to the pirin family
AMD12_RS09365	COG0583	DNA-binding transcription factor activity
AMD12_RS09390	COG0351	phosphomethylpyrimidine kinase
AMD12_RS09390	COG0352	thiamine-phosphate diphosphorylase activity
AMD12_RS09405	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AMD12_RS09410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMD12_RS09425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMD12_RS09435	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMD12_RS09440	COG3734	2-keto-3-deoxy-galactonokinase
AMD12_RS09450	COG4948	Mandelate Racemase Muconate Lactonizing
AMD12_RS09455	COG0800	Aldolase
AMD12_RS09495	COG1501	Belongs to the glycosyl hydrolase 31 family
AMD12_RS09505	COG1070	Carbohydrate kinase
AMD12_RS09510	COG2115	Belongs to the xylose isomerase family
AMD12_RS09515	COG0477	Major facilitator Superfamily
AMD12_RS09525	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMD12_RS09530	COG1469	GTP cyclohydrolase I activity
AMD12_RS09550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMD12_RS09555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AMD12_RS09560	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AMD12_RS09565	COG0166	Belongs to the GPI family
AMD12_RS09585	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD12_RS09595	COG5001	Diguanylate cyclase
AMD12_RS09595	COG3706	GGDEF domain
AMD12_RS09595	COG4251	negative regulation of phosphorylation
AMD12_RS09595	COG2203	Gaf domain
AMD12_RS09600	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD12_RS09605	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AMD12_RS09615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AMD12_RS09620	COG0671	phosphoesterase, PA-phosphatase related
AMD12_RS09630	COG1794	racemase activity, acting on amino acids and derivatives
AMD12_RS09635	COG0697	spore germination
AMD12_RS09640	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMD12_RS09645	COG0167	dihydroorotate dehydrogenase activity
AMD12_RS09660	COG1012	belongs to the aldehyde dehydrogenase family
AMD12_RS09675	COG1215	transferase activity, transferring glycosyl groups
AMD12_RS09680	COG1649	PFAM Uncharacterised BCR, COG1649
AMD12_RS09680	COG0726	polysaccharide deacetylase
AMD12_RS09695	COG3210	domain, Protein
AMD12_RS09700	COG3210	domain, Protein
AMD12_RS09740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD12_RS09745	COG0124	histidyl-tRNA synthetase
AMD12_RS09755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMD12_RS09760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMD12_RS09765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMD12_RS09770	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AMD12_RS09770	COG0131	Imidazoleglycerol-phosphate dehydratase
AMD12_RS09775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMD12_RS09780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AMD12_RS09785	COG0107	imidazoleglycerol-phosphate synthase activity
AMD12_RS09790	COG0140	phosphoribosyl-ATP diphosphatase activity
AMD12_RS09790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMD12_RS09805	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AMD12_RS09810	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AMD12_RS09815	COG0235	Class ii aldolase
AMD12_RS09820	COG0531	amino acid
AMD12_RS09825	COG0531	amino acid
AMD12_RS09835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMD12_RS09840	COG0277	FAD linked oxidase domain protein
AMD12_RS09860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMD12_RS09905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMD12_RS09910	COG2258	MOSC domain
AMD12_RS09915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMD12_RS09920	COG0505	Belongs to the CarA family
AMD12_RS09930	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AMD12_RS09935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD12_RS09945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMD12_RS09990	COG3279	Response regulator of the LytR AlgR family
AMD12_RS09995	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMD12_RS10000	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMD12_RS10010	COG0784	Response regulator, receiver
AMD12_RS10010	COG2205	protein histidine kinase activity
AMD12_RS10010	COG2198	Histidine kinase
AMD12_RS10015	COG1024	Enoyl-CoA hydratase
AMD12_RS10020	COG0318	PFAM AMP-dependent synthetase and ligase
AMD12_RS10050	COG2267	carboxylic ester hydrolase activity
AMD12_RS10060	COG2201	protein-glutamate methylesterase activity
AMD12_RS10065	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AMD12_RS10075	COG0840	transmembrane signaling receptor activity
AMD12_RS10080	COG0840	transmembrane signaling receptor activity
AMD12_RS10085	COG0840	transmembrane signaling receptor activity
AMD12_RS10095	COG0840	transmembrane signaling receptor activity
AMD12_RS10100	COG0840	transmembrane signaling receptor activity
AMD12_RS10105	COG0840	transmembrane signaling receptor activity
AMD12_RS10110	COG0840	transmembrane signaling receptor activity
AMD12_RS10125	COG0840	transmembrane signaling receptor activity
AMD12_RS10140	COG0840	transmembrane signaling receptor activity
AMD12_RS10145	COG0643	Histidine kinase
AMD12_RS10145	COG2198	Histidine kinase
AMD12_RS10150	COG0745	RESPONSE REGULATOR receiver
AMD12_RS10160	COG0835	chemotaxis
AMD12_RS10170	COG1360	Flagellar Motor Protein
AMD12_RS10175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AMD12_RS10260	COG0641	radical SAM
AMD12_RS10275	COG0784	Response regulator, receiver
AMD12_RS10275	COG0643	Histidine kinase
AMD12_RS10275	COG2198	Histidine kinase
AMD12_RS10305	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AMD12_RS10335	COG1684	flagellar biosynthetic protein fliR
AMD12_RS10350	COG3190	flagellar
AMD12_RS10400	COG1677	Flagellar hook-basal body complex protein FliE
AMD12_RS10430	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS10435	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS10440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD12_RS10460	COG2201	protein-glutamate methylesterase activity
AMD12_RS10490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AMD12_RS10495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AMD12_RS10500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AMD12_RS10510	COG3951	Flagellar rod assembly protein muramidase FlgJ
AMD12_RS10510	COG1705	Flagellar rod assembly protein muramidase FlgJ
AMD12_RS10515	COG1706	bacterial-type flagellum-dependent cell motility
AMD12_RS10520	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AMD12_RS10530	COG4787	bacterial-type flagellum-dependent cell motility
AMD12_RS10540	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AMD12_RS10545	COG1558	bacterial-type flagellum-dependent cell motility
AMD12_RS10555	COG0784	Response regulator, receiver
AMD12_RS10555	COG0835	chemotaxis
AMD12_RS10575	COG5002	protein histidine kinase activity
AMD12_RS10605	COG2915	High frequency lysogenization protein hflD homolog
AMD12_RS10610	COG0482	sulfurtransferase activity
AMD12_RS10625	COG0542	response to heat
AMD12_RS10635	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AMD12_RS10645	COG0492	ferredoxin-NADP+ reductase activity
AMD12_RS10650	COG1674	ftsk spoiiie
AMD12_RS10660	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AMD12_RS10670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AMD12_RS10675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMD12_RS10685	COG0183	Belongs to the thiolase family
AMD12_RS10690	COG1024	Enoyl-CoA hydratase
AMD12_RS10690	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD12_RS10705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMD12_RS10715	COG1426	Protein conserved in bacteria
AMD12_RS10725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD12_RS10730	COG1160	GTP binding
AMD12_RS10735	COG0303	'Molybdopterin
AMD12_RS10740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMD12_RS10775	COG0708	Exodeoxyribonuclease III
AMD12_RS10785	COG0303	'Molybdopterin
AMD12_RS10790	COG0746	molybdenum cofactor guanylyltransferase activity
AMD12_RS10805	COG1914	H( )-stimulated, divalent metal cation uptake system
AMD12_RS10820	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AMD12_RS10825	COG0668	transmembrane transport
AMD12_RS10835	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AMD12_RS10850	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS10855	COG1183	phosphatidylcholine synthase activity
AMD12_RS10865	COG3243	poly(R)-hydroxyalkanoic acid synthase
AMD12_RS10880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD12_RS10880	COG0723	plastoquinol--plastocyanin reductase activity
AMD12_RS10890	COG2183	response to ionizing radiation
AMD12_RS10895	COG2205	protein histidine kinase activity
AMD12_RS10895	COG0784	Response regulator, receiver
AMD12_RS10960	COG0800	Aldolase
AMD12_RS10965	COG0129	dihydroxy-acid dehydratase activity
AMD12_RS10970	COG0363	glucosamine-6-phosphate deaminase activity
AMD12_RS10975	COG0837	glucose binding
AMD12_RS10980	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AMD12_RS11000	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AMD12_RS11015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMD12_RS11020	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AMD12_RS11030	COG4591	ABC-type transport system involved in lipoprotein release permease component
AMD12_RS11035	COG1136	(ABC) transporter
AMD12_RS11050	COG0811	peptide transport
AMD12_RS11060	COG1132	(ABC) transporter
AMD12_RS11065	COG1663	tetraacyldisaccharide 4'-kinase activity
AMD12_RS11070	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AMD12_RS11075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMD12_RS11085	COG0322	excinuclease ABC activity
AMD12_RS11090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD12_RS11110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD12_RS11115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD12_RS11130	COG2801	Transposase and inactivated derivatives
AMD12_RS11140	COG0582	viral genome integration into host DNA
AMD12_RS11150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AMD12_RS11170	COG1054	Belongs to the UPF0176 family
AMD12_RS11180	COG1530	ribonuclease E activity
AMD12_RS11190	COG3064	Membrane
AMD12_RS11195	COG0428	transporter
AMD12_RS11205	COG2154	pterin-4-alpha-carbinolamine dehydratase
AMD12_RS11210	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AMD12_RS11210	COG0316	Belongs to the HesB IscA family
AMD12_RS11265	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS11300	COG1238	metal cluster binding
AMD12_RS11335	COG3279	Response regulator of the LytR AlgR family
AMD12_RS11380	COG4566	intracellular signal transduction
AMD12_RS11390	COG5001	Diguanylate cyclase
AMD12_RS11405	COG3685	Protein conserved in bacteria
AMD12_RS11420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMD12_RS11420	COG1648	precorrin-2 dehydrogenase activity
AMD12_RS11435	COG2814	Major facilitator Superfamily
AMD12_RS11455	COG1335	isochorismatase
AMD12_RS11470	COG2197	response regulator
AMD12_RS11490	COG0583	DNA-binding transcription factor activity
AMD12_RS11495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMD12_RS11500	COG3002	Belongs to the UPF0753 family
AMD12_RS11515	COG1396	sequence-specific DNA binding
AMD12_RS11520	COG5489	Protein of unknown function (DUF736)
AMD12_RS11525	COG2003	Belongs to the UPF0758 family
AMD12_RS11550	COG0582	viral genome integration into host DNA
AMD12_RS11565	COG4774	siderophore transport
AMD12_RS11580	COG2336	PFAM SpoVT AbrB
AMD12_RS11605	COG4206	TonB-dependent receptor
AMD12_RS11625	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AMD12_RS11625	COG2273	Hydrolase Family 16
AMD12_RS11645	COG2274	protein secretion by the type I secretion system
AMD12_RS11700	COG0270	DNA (cytosine-5-)-methyltransferase activity
AMD12_RS11750	COG4804	nuclease activity
AMD12_RS11770	COG5006	permease, DMT superfamily
AMD12_RS11785	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMD12_RS11795	COG3938	Belongs to the proline racemase family
AMD12_RS11810	COG2807	transmembrane transport
AMD12_RS11815	COG2207	Transcriptional regulator
AMD12_RS11965	COG0210	DNA helicase
AMD12_RS12045	COG2084	Dehydrogenase
AMD12_RS12065	COG2003	Belongs to the UPF0758 family
AMD12_RS12100	COG0582	viral genome integration into host DNA
AMD12_RS12105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD12_RS12105	COG0519	Catalyzes the synthesis of GMP from XMP
AMD12_RS12115	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMD12_RS12125	COG0475	glutathione-regulated potassium exporter activity
AMD12_RS12125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMD12_RS12130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMD12_RS12140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMD12_RS12145	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AMD12_RS12155	COG0776	regulation of translation
AMD12_RS12160	COG0539	negative regulation of cytoplasmic translation
AMD12_RS12165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AMD12_RS12180	COG2957	Belongs to the agmatine deiminase family
AMD12_RS12185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD12_RS12210	COG0395	ABC-type sugar transport system, permease component
AMD12_RS12215	COG1175	transmembrane transport
AMD12_RS12245	COG2350	Protein conserved in bacteria
AMD12_RS12250	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AMD12_RS12255	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMD12_RS12260	COG1187	pseudouridine synthase activity
AMD12_RS12280	COG0436	Aminotransferase
AMD12_RS12285	COG4133	protoheme IX ABC transporter activity
AMD12_RS12305	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AMD12_RS12310	COG1138	Cytochrome C-type biogenesis protein
AMD12_RS12330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD12_RS12335	COG1278	Cold shock
AMD12_RS12340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AMD12_RS12345	COG4988	ABC transporter
AMD12_RS12355	COG1294	oxidase, subunit
AMD12_RS12380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AMD12_RS12385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AMD12_RS12395	COG0165	Argininosuccinate lyase
AMD12_RS12400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AMD12_RS12410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMD12_RS12415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMD12_RS12425	COG0137	argininosuccinate synthase activity
AMD12_RS12430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMD12_RS12440	COG0215	cysteine-tRNA ligase activity
AMD12_RS12445	COG2166	iron-sulfur cluster assembly
AMD12_RS12465	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AMD12_RS12470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMD12_RS12495	COG4302	ethanolamine ammonia-lyase activity
AMD12_RS12525	COG2963	transposase activity
AMD12_RS12545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMD12_RS12550	COG0402	S-adenosylhomocysteine deaminase activity
AMD12_RS12560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMD12_RS12565	COG1509	lysine 2,3-aminomutase activity
AMD12_RS12570	COG3300	MHYT domain
AMD12_RS12570	COG5001	Diguanylate cyclase
AMD12_RS12585	COG0483	inositol monophosphate 1-phosphatase activity
AMD12_RS12590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AMD12_RS12605	COG0488	(ABC) transporter
AMD12_RS12610	COG0513	Belongs to the DEAD box helicase family
AMD12_RS12615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMD12_RS12620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AMD12_RS12630	COG0625	glutathione transferase activity
AMD12_RS12640	COG4681	YaeQ
AMD12_RS12645	COG2081	HI0933 family
AMD12_RS12655	COG0501	Belongs to the peptidase M48B family
AMD12_RS12660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD12_RS12665	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS12685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AMD12_RS12690	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMD12_RS12695	COG0802	atpase or kinase
AMD12_RS12700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMD12_RS12700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AMD12_RS12705	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMD12_RS12710	COG1570	exodeoxyribonuclease VII activity
AMD12_RS12720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMD12_RS12900	COG0835	chemotaxis
AMD12_RS12905	COG0840	transmembrane signaling receptor activity
AMD12_RS12910	COG2094	Belongs to the DNA glycosylase MPG family
AMD12_RS12915	COG1201	RNA secondary structure unwinding
AMD12_RS12930	COG2969	positive regulation of protein catabolic process
AMD12_RS12935	COG0625	glutathione transferase activity
AMD12_RS12940	COG2857	Cytochrome c1
AMD12_RS12945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AMD12_RS12950	COG0723	plastoquinol--plastocyanin reductase activity
AMD12_RS12955	COG0741	lytic transglycosylase activity
AMD12_RS12970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMD12_RS12975	COG1702	phosphate starvation-inducible protein PhoH
AMD12_RS12985	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMD12_RS12995	COG4535	Mg2 and Co2 transporter CorC
AMD12_RS13010	COG1012	belongs to the aldehyde dehydrogenase family
AMD12_RS13020	COG1177	transmembrane transport
AMD12_RS13025	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMD12_RS13030	COG3842	ATPase activity
AMD12_RS13050	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AMD12_RS13065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMD12_RS13070	COG0174	glutamine synthetase
AMD12_RS13075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD12_RS13085	COG2703	oxygen carrier activity
AMD12_RS13090	COG0477	Major facilitator Superfamily
AMD12_RS13100	COG0243	molybdopterin cofactor binding
AMD12_RS13105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMD12_RS13110	COG2223	nitrite transmembrane transporter activity
AMD12_RS13120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMD12_RS13130	COG2733	membrane
AMD12_RS13135	COG5002	protein histidine kinase activity
AMD12_RS13135	COG2205	protein histidine kinase activity
AMD12_RS13135	COG0784	Response regulator, receiver
AMD12_RS13145	COG0477	Major facilitator Superfamily
AMD12_RS13150	COG2902	Dehydrogenase
AMD12_RS13160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD12_RS13165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD12_RS13170	COG1609	Transcriptional regulator
AMD12_RS13175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD12_RS13175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMD12_RS13180	COG1105	Belongs to the carbohydrate kinase PfkB family
AMD12_RS13185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMD12_RS13185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMD12_RS13220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMD12_RS13230	COG1862	Preprotein translocase
AMD12_RS13235	COG0343	queuine tRNA-ribosyltransferase activity
AMD12_RS13240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMD12_RS13280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AMD12_RS13285	COG3291	Pkd domain containing protein
AMD12_RS13295	COG0405	Gamma-glutamyltransferase
AMD12_RS13300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMD12_RS13315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMD12_RS13320	COG0742	ribosomal rna small subunit methyltransferase
AMD12_RS13325	COG0326	Molecular chaperone. Has ATPase activity
AMD12_RS13395	COG0531	amino acid
AMD12_RS13410	COG0006	proline dipeptidase activity
AMD12_RS13420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMD12_RS13435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD12_RS13440	COG3938	Belongs to the proline racemase family
AMD12_RS13450	COG0552	protein localization to endoplasmic reticulum
AMD12_RS13455	COG1194	a g-specific adenine glycosylase
AMD12_RS13460	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AMD12_RS13465	COG0784	Response regulator, receiver
AMD12_RS13465	COG4191	Histidine kinase
AMD12_RS13480	COG0322	excinuclease ABC activity
AMD12_RS13495	COG3040	lipid binding
AMD12_RS13505	COG1960	acyl-CoA dehydrogenase activity
AMD12_RS13515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AMD12_RS13535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD12_RS13540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD12_RS13545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD12_RS13570	COG0438	transferase activity, transferring glycosyl groups
AMD12_RS13580	COG0438	transferase activity, transferring glycosyl groups
AMD12_RS13585	COG0438	transferase activity, transferring glycosyl groups
AMD12_RS13635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD12_RS13635	COG0072	phenylalanine-tRNA ligase activity
AMD12_RS13640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMD12_RS13655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AMD12_RS13660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMD12_RS13685	COG1082	Xylose isomerase domain protein TIM barrel
AMD12_RS13700	COG0366	Alpha amylase catalytic
AMD12_RS13705	COG2963	transposase activity
AMD12_RS13770	COG2948	multi-organism process
AMD12_RS13790	COG3505	Type IV secretory pathway VirD4
AMD12_RS13805	COG0556	nucleotide-excision repair
AMD12_RS13875	COG4695	Portal protein
AMD12_RS13920	COG3179	chitinase
AMD12_RS14015	COG3275	phosphorelay sensor kinase activity
AMD12_RS14020	COG1611	Belongs to the LOG family
AMD12_RS14030	COG2095	MarC family integral membrane protein
AMD12_RS14040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AMD12_RS14075	COG1185	polyribonucleotide nucleotidyltransferase activity
AMD12_RS14080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMD12_RS14085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMD12_RS14090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AMD12_RS14095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AMD12_RS14100	COG0195	Participates in both transcription termination and antitermination
AMD12_RS14105	COG0779	Required for maturation of 30S ribosomal subunits
AMD12_RS14115	COG1007	ATP synthesis coupled electron transport
AMD12_RS14140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD12_RS14145	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AMD12_RS14155	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AMD12_RS14160	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AMD12_RS14165	COG0649	NAD binding
AMD12_RS14170	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD12_RS14175	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD12_RS14180	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD12_RS14195	COG0149	triose-phosphate isomerase activity
AMD12_RS14200	COG0300	oxidoreductase activity
AMD12_RS14235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD12_RS14240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AMD12_RS14245	COG0159	tryptophan synthase activity
AMD12_RS14255	COG0133	tryptophan synthase activity
AMD12_RS14265	COG0135	phosphoribosylanthranilate isomerase activity
AMD12_RS14270	COG0101	tRNA pseudouridine synthase activity
AMD12_RS14290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AMD12_RS14295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMD12_RS14300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AMD12_RS14305	COG2890	protein-(glutamine-N5) methyltransferase activity
AMD12_RS14315	COG0688	phosphatidylethanolamine metabolic process
AMD12_RS14325	COG0433	COG0433 Predicted ATPase
AMD12_RS14330	COG0494	nUDIX hydrolase
AMD12_RS14345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD12_RS14350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMD12_RS14375	COG0717	Belongs to the dCTP deaminase family
AMD12_RS14380	COG0489	protein tyrosine kinase activity
AMD12_RS14400	COG3590	peptidase
AMD12_RS14405	COG3590	peptidase
AMD12_RS14425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMD12_RS14430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD12_RS14435	COG2311	Membrane
AMD12_RS14440	COG1047	Peptidyl-prolyl cis-trans
AMD12_RS14445	COG0791	NLP P60 protein
AMD12_RS14450	COG0791	NLP P60 protein
AMD12_RS14460	COG4106	trans-aconitate 2-methyltransferase activity
AMD12_RS14465	COG1301	dicarboxylic acid transport
AMD12_RS14470	COG1785	Belongs to the alkaline phosphatase family
AMD12_RS14475	COG0037	tRNA processing
AMD12_RS14480	COG1722	exodeoxyribonuclease VII activity
AMD12_RS14485	COG0142	geranyltranstransferase activity
AMD12_RS14490	COG4104	PAAR repeat-containing protein
AMD12_RS14500	COG0312	modulator of DNA gyrase
AMD12_RS14505	COG3028	Belongs to the UPF0307 family
AMD12_RS14510	COG0312	modulator of DNA gyrase
AMD12_RS14520	COG3164	Protein of unknown function
AMD12_RS14530	COG0424	maF-like protein
AMD12_RS14535	COG2968	Membrane
AMD12_RS14550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AMD12_RS14565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMD12_RS14580	COG0495	leucyl-tRNA aminoacylation
AMD12_RS14590	COG3118	belongs to the thioredoxin family
AMD12_RS14615	COG2155	Conserved Protein
AMD12_RS14660	COG1132	(ABC) transporter
AMD12_RS14685	COG1538	Outer membrane efflux protein
AMD12_RS14690	COG0745	RESPONSE REGULATOR receiver
AMD12_RS14695	COG5002	protein histidine kinase activity
AMD12_RS14695	COG5000	phosphorelay sensor kinase activity
AMD12_RS14700	COG0475	glutathione-regulated potassium exporter activity
AMD12_RS14710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMD12_RS14735	COG1187	pseudouridine synthase activity
AMD12_RS14740	COG5002	protein histidine kinase activity
AMD12_RS14740	COG5001	Diguanylate cyclase
AMD12_RS14855	COG0667	Aldo Keto reductase
AMD12_RS14860	COG2814	Major facilitator Superfamily
AMD12_RS14865	COG0583	DNA-binding transcription factor activity
AMD12_RS14875	COG2207	Transcriptional regulator
AMD12_RS14885	COG1309	transcriptional regulator
AMD12_RS14910	COG0735	belongs to the Fur family
AMD12_RS14915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD12_RS14940	COG4452	Inner membrane protein CreD
AMD12_RS14950	COG2205	protein histidine kinase activity
AMD12_RS14955	COG0745	RESPONSE REGULATOR receiver
AMD12_RS14960	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AMD12_RS14970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AMD12_RS15005	COG2198	Histidine kinase
AMD12_RS15005	COG0643	Histidine kinase
AMD12_RS15010	COG0840	transmembrane signaling receptor activity
AMD12_RS15015	COG0835	chemotaxis
AMD12_RS15020	COG2199	diguanylate cyclase activity
AMD12_RS15020	COG2200	EAL domain
AMD12_RS15020	COG2202	Pas domain
AMD12_RS15025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AMD12_RS15030	COG2201	protein-glutamate methylesterase activity
AMD12_RS15035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD12_RS15040	COG3590	peptidase
AMD12_RS15050	COG0588	phosphoglycerate mutase activity
AMD12_RS15055	COG1515	deoxyribonuclease V activity
AMD12_RS15065	COG1741	Belongs to the pirin family
AMD12_RS15080	COG1741	Belongs to the pirin family
AMD12_RS15085	COG1966	Carbon starvation protein
AMD12_RS15090	COG2879	small protein
AMD12_RS15145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMD12_RS15150	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMD12_RS15155	COG2080	2 iron, 2 sulfur cluster binding
AMD12_RS15165	COG5001	Diguanylate cyclase
AMD12_RS15165	COG3706	GGDEF domain
AMD12_RS15165	COG2203	Gaf domain
AMD12_RS15165	COG4251	negative regulation of phosphorylation
AMD12_RS15205	COG0629	single-stranded DNA binding
AMD12_RS15210	COG0142	geranyltranstransferase activity
AMD12_RS15220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMD12_RS15235	COG0527	aspartate kinase activity
AMD12_RS15240	COG0384	phenazine biosynthesis protein PhzF
AMD12_RS15245	COG0384	phenazine biosynthesis protein PhzF
AMD12_RS15255	COG1764	response to oxidative stress
AMD12_RS15260	COG0540	Belongs to the ATCase OTCase family
AMD12_RS15265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AMD12_RS15270	COG1678	Uncharacterized ACR, COG1678
AMD12_RS15280	COG0519	Catalyzes the synthesis of GMP from XMP
AMD12_RS15290	COG5297	Belongs to the glycosyl hydrolase family 6
AMD12_RS15305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AMD12_RS15320	COG0739	heme binding
AMD12_RS15340	COG0693	protein deglycase activity
AMD12_RS15350	COG1959	2 iron, 2 sulfur cluster binding
AMD12_RS15355	COG0719	Fe-S assembly protein
AMD12_RS15360	COG0396	ATPase activity
AMD12_RS15365	COG0719	Fe-S assembly protein
AMD12_RS15370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMD12_RS15380	COG2146	nitrite reductase [NAD(P)H] activity
AMD12_RS15385	COG4774	siderophore transport
AMD12_RS15390	COG3128	pkhd-type hydroxylase
AMD12_RS15415	COG1477	protein flavinylation
AMD12_RS15420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AMD12_RS15435	COG1555	photosystem II stabilization
AMD12_RS15440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMD12_RS15450	COG3178	'Phosphotransferase
AMD12_RS15455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMD12_RS15465	COG0628	permease
AMD12_RS15475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMD12_RS15485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AMD12_RS15505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMD12_RS15510	COG0271	Belongs to the BolA IbaG family
AMD12_RS15520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AMD12_RS15530	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AMD12_RS15535	COG1137	ATPase activity
AMD12_RS15550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD12_RS15555	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AMD12_RS15560	COG1660	Displays ATPase and GTPase activities
AMD12_RS15570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD12_RS15575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMD12_RS15580	COG2239	Acts as a magnesium transporter
AMD12_RS15590	COG1294	oxidase, subunit
AMD12_RS15595	COG1271	oxidase subunit
AMD12_RS15605	COG1113	amino acid transport
AMD12_RS15625	COG2197	response regulator
AMD12_RS15630	COG0531	amino acid
AMD12_RS15650	COG1234	tRNA 3'-trailer cleavage
AMD12_RS15685	COG2814	Major facilitator Superfamily
AMD12_RS15695	COG0754	glutathionylspermidine amidase activity
AMD12_RS15720	COG1842	Phage shock protein A
AMD12_RS15730	COG0259	pyridoxamine-phosphate oxidase activity
AMD12_RS15735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMD12_RS15740	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AMD12_RS15750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AMD12_RS15825	COG2814	Major facilitator Superfamily
AMD12_RS15845	COG2198	Histidine kinase
AMD12_RS15845	COG2205	protein histidine kinase activity
AMD12_RS15845	COG0784	Response regulator, receiver
AMD12_RS15850	COG2353	YceI-like domain
AMD12_RS15870	COG1760	l-serine dehydratase
AMD12_RS15880	COG0527	aspartate kinase activity
AMD12_RS15880	COG0460	homoserine dehydrogenase
AMD12_RS15885	COG0626	cystathionine gamma-synthase activity
AMD12_RS15890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD12_RS15895	COG0739	heme binding
AMD12_RS15900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AMD12_RS15905	COG1272	protein, Hemolysin III
AMD12_RS15910	COG2982	Protein involved in outer membrane biogenesis
AMD12_RS15915	COG0516	GMP reductase activity
AMD12_RS15915	COG0517	IMP dehydrogenase activity
AMD12_RS15920	COG0463	Glycosyl transferase, family 2
AMD12_RS15925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMD12_RS15930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AMD12_RS15940	COG4771	TonB-dependent receptor
AMD12_RS15950	COG1309	transcriptional regulator
AMD12_RS15960	COG1960	acyl-CoA dehydrogenase activity
AMD12_RS15985	COG0509	glycine decarboxylation via glycine cleavage system
AMD12_RS15990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMD12_RS16000	COG0330	HflC and HflK could
AMD12_RS16005	COG1742	UPF0060 membrane protein
AMD12_RS16010	COG3956	TIGRFAM MazG family protein
AMD12_RS16020	COG0494	nUDIX hydrolase
AMD12_RS16030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AMD12_RS16035	COG0837	glucose binding
AMD12_RS16050	COG1388	LysM domain
AMD12_RS16050	COG3858	chitin binding
AMD12_RS16055	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AMD12_RS16065	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD12_RS16080	COG0531	amino acid
AMD12_RS16090	COG1486	melibiose metabolic process
AMD12_RS16100	COG3537	Alpha-1,2-mannosidase
AMD12_RS16135	COG3142	Participates in the control of copper homeostasis
AMD12_RS16140	COG1446	asparaginase
AMD12_RS16165	COG0643	Histidine kinase
AMD12_RS16165	COG0784	Response regulator, receiver
AMD12_RS16165	COG2198	Histidine kinase
AMD12_RS16170	COG0840	transmembrane signaling receptor activity
AMD12_RS16175	COG0835	chemotaxis
AMD12_RS16190	COG0189	ligase activity
AMD12_RS16200	COG1397	ADP-ribosylglycohydrolase
AMD12_RS16210	COG1199	ATP-dependent helicase activity
AMD12_RS16220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMD12_RS16225	COG1215	transferase activity, transferring glycosyl groups
AMD12_RS16235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD12_RS16240	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMD12_RS16245	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AMD12_RS16250	COG0535	radical SAM domain protein
AMD12_RS16255	COG0535	radical SAM domain protein
AMD12_RS16270	COG0837	glucose binding
AMD12_RS16280	COG1643	Atp-dependent helicase
AMD12_RS16285	COG0783	Belongs to the Dps family
AMD12_RS16290	COG0514	ATP-dependent DNA helicase (RecQ)
AMD12_RS16325	COG0840	transmembrane signaling receptor activity
AMD12_RS16345	COG3920	Histidine kinase
AMD12_RS16350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AMD12_RS16360	COG0602	queuosine metabolic process
AMD12_RS16370	COG2885	chlorophyll binding
AMD12_RS16375	COG0823	Involved in the tonB-independent uptake of proteins
AMD12_RS16385	COG0848	biopolymer transport protein
AMD12_RS16395	COG0824	Thioesterase
AMD12_RS16400	COG2255	four-way junction helicase activity
AMD12_RS16410	COG3158	transport of potassium into the cell
AMD12_RS16415	COG0632	four-way junction helicase activity
AMD12_RS16420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMD12_RS16425	COG0217	transcriptional regulatory protein
AMD12_RS16440	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMD12_RS16455	COG0477	Major facilitator Superfamily
AMD12_RS16490	COG0488	(ABC) transporter
AMD12_RS16525	COG4651	solute:proton antiporter activity
AMD12_RS16525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMD12_RS16550	COG4772	TonB-dependent receptor
AMD12_RS16560	COG4264	IucA IucC family
AMD12_RS16575	COG0019	diaminopimelate decarboxylase activity
AMD12_RS16600	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AMD12_RS16610	COG1492	cobalamin metabolic process
AMD12_RS16620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMD12_RS16640	COG4206	TonB-dependent receptor
AMD12_RS16645	COG0542	response to heat
AMD12_RS16650	COG1116	anion transmembrane transporter activity
AMD12_RS16655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD12_RS16660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMD12_RS16665	COG0667	Aldo Keto reductase
AMD12_RS16670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD12_RS16675	COG4771	TonB-dependent receptor
AMD12_RS16680	COG2827	Endonuclease containing a URI domain
AMD12_RS16720	COG1877	trehalose-phosphatase activity
AMD12_RS16725	COG3387	PFAM Glycoside hydrolase 15-related
AMD12_RS16740	COG0840	transmembrane signaling receptor activity
AMD12_RS16745	COG3011	Protein conserved in bacteria
AMD12_RS16760	COG0564	pseudouridine synthase activity
AMD12_RS16765	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD12_RS16775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AMD12_RS16775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD12_RS16805	COG2951	lytic endotransglycosylase activity
AMD12_RS16810	COG4644	lycopene metabolic process
AMD12_RS16830	COG2369	cell adhesion
AMD12_RS16855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AMD12_RS16860	COG0045	succinate-CoA ligase (ADP-forming) activity
AMD12_RS16875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD12_RS16905	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AMD12_RS16910	COG0237	dephospho-CoA kinase activity
AMD12_RS16930	COG2801	Transposase and inactivated derivatives
AMD12_RS16935	COG5002	protein histidine kinase activity
AMD12_RS16940	COG0745	RESPONSE REGULATOR receiver
AMD12_RS16950	COG0189	ligase activity
AMD12_RS17010	COG2003	Belongs to the UPF0758 family
AMD12_RS17035	COG4191	Histidine kinase
AMD12_RS17035	COG0784	Response regulator, receiver
AMD12_RS17040	COG0784	Response regulator, receiver
AMD12_RS17040	COG4191	Histidine kinase
AMD12_RS17150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMD12_RS17175	COG2022	thiamine diphosphate biosynthetic process
AMD12_RS17180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMD12_RS17185	COG0471	metal ion transport
AMD12_RS17185	COG3273	potassium ion transport
AMD12_RS17205	COG1970	mechanosensitive ion channel activity
AMD12_RS17230	COG3250	beta-galactosidase activity
AMD12_RS17235	COG4948	Mandelate Racemase Muconate Lactonizing
AMD12_RS17250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD12_RS17260	COG0308	aminopeptidase N
AMD12_RS17310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD12_RS17320	COG0529	Catalyzes the synthesis of activated sulfate
AMD12_RS17320	COG2895	sulfate adenylyltransferase (ATP) activity
AMD12_RS17325	COG0175	sulfate reduction
AMD12_RS17330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AMD12_RS17335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMD12_RS17340	COG0175	sulfate reduction
AMD12_RS17360	COG2198	Histidine kinase
AMD12_RS17360	COG0784	Response regulator, receiver
AMD12_RS17360	COG2205	protein histidine kinase activity
AMD12_RS17395	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AMD12_RS17400	COG3588	fructose-bisphosphate aldolase
AMD12_RS17405	COG0469	pyruvate kinase activity
AMD12_RS17415	COG0126	phosphoglycerate kinase activity
AMD12_RS17435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AMD12_RS17445	COG3047	cAMP biosynthetic process
AMD12_RS17450	COG3047	cAMP biosynthetic process
AMD12_RS17460	COG3453	Protein conserved in bacteria
AMD12_RS17460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD12_RS17465	COG0725	ABC transporter, periplasmic molybdate-binding protein
AMD12_RS17470	COG4149	molybdate abc transporter
AMD12_RS17475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AMD12_RS17510	COG1376	ErfK ybiS ycfS ynhG family protein
AMD12_RS17515	COG0739	heme binding
AMD12_RS17525	COG4773	Receptor
AMD12_RS17540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AMD12_RS17545	COG1301	dicarboxylic acid transport
AMD12_RS17555	COG2304	oxidoreductase activity
AMD12_RS17575	COG0714	Associated with various cellular activities
AMD12_RS17605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AMD12_RS17630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AMD12_RS17640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD12_RS17650	COG0194	GDP metabolic process
AMD12_RS17655	COG1561	YicC-like family, N-terminal region
AMD12_RS17660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMD12_RS17670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMD12_RS17675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMD12_RS17690	COG0006	proline dipeptidase activity
AMD12_RS17700	COG0006	proline dipeptidase activity
AMD12_RS17705	COG3079	Belongs to the UPF0149 family
AMD12_RS17720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMD12_RS17730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AMD12_RS17740	COG2912	Transglutaminase-like superfamily
AMD12_RS17745	COG1773	rubredoxin
AMD12_RS17750	COG0352	thiamine-phosphate diphosphorylase activity
AMD12_RS17765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMD12_RS17780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMD12_RS17810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMD12_RS17815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD12_RS17820	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS17830	COG0671	phosphoesterase, PA-phosphatase related
AMD12_RS17835	COG3781	membrane
AMD12_RS17845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMD12_RS17850	COG0563	adenylate kinase activity
AMD12_RS17865	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AMD12_RS17875	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMD12_RS17895	COG3710	Transcriptional regulator
AMD12_RS17900	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMD12_RS17910	COG0840	transmembrane signaling receptor activity
AMD12_RS17915	COG0405	Gamma-glutamyltransferase
AMD12_RS17920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMD12_RS17940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMD12_RS17945	COG0473	3-isopropylmalate dehydrogenase activity
AMD12_RS17950	COG0066	3-isopropylmalate dehydratase activity
AMD12_RS17955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMD12_RS17975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMD12_RS17980	COG1538	Outer membrane efflux protein
AMD12_RS17985	COG1519	Transferase
AMD12_RS17990	COG1560	Kdo2-lipid A biosynthetic process
AMD12_RS18015	COG0280	phosphate acetyltransferase
AMD12_RS18015	COG0281	malic enzyme
AMD12_RS18020	COG1301	dicarboxylic acid transport
AMD12_RS18045	COG0583	DNA-binding transcription factor activity
AMD12_RS18050	COG0667	Aldo Keto reductase
AMD12_RS18065	COG2197	response regulator
AMD12_RS18075	COG0642	Histidine kinase
AMD12_RS18090	COG2851	Citrate transporter
AMD12_RS18095	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS18100	COG1609	Transcriptional regulator
AMD12_RS18105	COG2211	Major facilitator Superfamily
AMD12_RS18130	COG1162	GTPase activity
AMD12_RS18150	COG4773	Receptor
AMD12_RS18155	COG0726	polysaccharide deacetylase
AMD12_RS18160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AMD12_RS18175	COG2963	transposase activity
AMD12_RS18180	COG2801	Transposase and inactivated derivatives
AMD12_RS18195	COG1307	EDD domain protein, DegV family
AMD12_RS18200	COG0242	peptide deformylase activity
AMD12_RS18220	COG0457	Tetratricopeptide repeat
AMD12_RS18225	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AMD12_RS18230	COG1215	transferase activity, transferring glycosyl groups
AMD12_RS18235	COG1215	transferase activity, transferring glycosyl groups
AMD12_RS18250	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AMD12_RS18305	COG2188	Transcriptional regulator
AMD12_RS18315	COG1450	Type ii and iii secretion system protein
AMD12_RS18330	COG3166	PFAM Fimbrial assembly family protein
AMD12_RS18335	COG3156	type II secretion system protein K
AMD12_RS18340	COG4795	General secretion pathway protein
AMD12_RS18345	COG2165	general secretion pathway protein
AMD12_RS18350	COG4970	Tfp pilus assembly protein FimT
AMD12_RS18355	COG2165	general secretion pathway protein
AMD12_RS18360	COG1459	type II secretion system
AMD12_RS18365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD12_RS18370	COG1404	Belongs to the peptidase S8 family
AMD12_RS18375	COG5295	Hep Hag repeat protein
AMD12_RS18380	COG1404	Belongs to the peptidase S8 family
AMD12_RS18385	COG5295	Hep Hag repeat protein
AMD12_RS18395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMD12_RS18395	COG0047	phosphoribosylformylglycinamidine synthase activity
AMD12_RS18400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMD12_RS18405	COG4974	Belongs to the 'phage' integrase family
AMD12_RS18420	COG0795	lipopolysaccharide-transporting ATPase activity
AMD12_RS18430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMD12_RS18445	COG0525	valine-tRNA ligase activity
AMD12_RS18475	COG1183	phosphatidylcholine synthase activity
AMD12_RS18485	COG0442	prolyl-tRNA aminoacylation
AMD12_RS18500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMD12_RS18505	COG1127	ABC transporter
AMD12_RS18510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMD12_RS18510	COG3218	ABC-type transport auxiliary lipoprotein component
AMD12_RS18545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD12_RS18550	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AMD12_RS18550	COG0662	Cupin 2, conserved barrel domain protein
AMD12_RS18580	COG2086	electron transfer activity
AMD12_RS18595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMD12_RS18595	COG0546	phosphoglycolate phosphatase activity
AMD12_RS18600	COG0277	FAD linked oxidase domain protein
AMD12_RS18615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD12_RS18645	COG1216	Glycosyl transferase, family 2
AMD12_RS18645	COG0438	transferase activity, transferring glycosyl groups
AMD12_RS18665	COG0626	cystathionine gamma-synthase activity
AMD12_RS18700	COG0625	glutathione transferase activity
AMD12_RS18710	COG0513	Belongs to the DEAD box helicase family
AMD12_RS18720	COG4206	TonB-dependent receptor
AMD12_RS18725	COG0720	synthase
AMD12_RS18735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AMD12_RS18745	COG1956	GAF domain-containing protein
AMD12_RS18755	COG2819	hydrolase of the alpha beta superfamily
AMD12_RS18770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMD12_RS18775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD12_RS18790	COG0339	signal peptide processing
AMD12_RS18840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMD12_RS18845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD12_RS18850	COG1136	(ABC) transporter
AMD12_RS18850	COG4591	ABC-type transport system involved in lipoprotein release permease component
AMD12_RS18855	COG1136	(ABC) transporter
AMD12_RS18855	COG0577	efflux transmembrane transporter activity
AMD12_RS18860	COG0577	efflux transmembrane transporter activity
AMD12_RS18875	COG4191	Histidine kinase
AMD12_RS18880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMD12_RS18895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AMD12_RS18900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AMD12_RS18905	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AMD12_RS18910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMD12_RS18915	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMD12_RS18920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMD12_RS18930	COG0356	it plays a direct role in the translocation of protons across the membrane
AMD12_RS18950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMD12_RS18960	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMD12_RS19005	COG2011	ABC-type metal ion transport system permease component
AMD12_RS19010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMD12_RS19015	COG0697	spore germination
AMD12_RS19020	COG1666	GTP binding
AMD12_RS19030	COG5002	protein histidine kinase activity
AMD12_RS19030	COG2198	Histidine kinase
AMD12_RS19030	COG0784	Response regulator, receiver
AMD12_RS19055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMD12_RS19060	COG1187	pseudouridine synthase activity
AMD12_RS19065	COG2813	Specifically methylates the guanine in position
AMD12_RS19085	COG2202	Pas domain
AMD12_RS19085	COG2205	protein histidine kinase activity
AMD12_RS19105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMD12_RS19110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD12_RS19165	COG0842	Transport permease protein
AMD12_RS19170	COG1131	(ABC) transporter
AMD12_RS19175	COG0025	NhaP-type Na H and K H
AMD12_RS19180	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AMD12_RS19185	COG1573	uracil-dna glycosylase
AMD12_RS19195	COG3384	dioxygenase
AMD12_RS19205	COG0583	DNA-binding transcription factor activity
AMD12_RS19215	COG0667	Aldo Keto reductase
AMD12_RS19225	COG3590	peptidase
AMD12_RS19245	COG0531	amino acid
AMD12_RS19260	COG2972	Histidine kinase
AMD12_RS19275	COG3685	Protein conserved in bacteria
AMD12_RS19280	COG3546	catalase activity
AMD12_RS19325	COG1271	oxidase subunit
AMD12_RS19330	COG1294	oxidase, subunit
AMD12_RS19345	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS19350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMD12_RS19370	COG1132	(ABC) transporter
AMD12_RS19385	COG1063	alcohol dehydrogenase
AMD12_RS19460	COG0251	oxidation-reduction process
AMD12_RS19490	COG0840	transmembrane signaling receptor activity
AMD12_RS19510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMD12_RS19550	COG0024	Methionine aminopeptidase
AMD12_RS19570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMD12_RS19575	COG1490	D-aminoacyl-tRNA deacylase activity
AMD12_RS19580	COG1560	Kdo2-lipid A biosynthetic process
AMD12_RS19630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AMD12_RS19630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMD12_RS19635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMD12_RS19640	COG0242	peptide deformylase activity
AMD12_RS19645	COG1652	LysM domain
AMD12_RS19650	COG0758	DNA mediated transformation
AMD12_RS19655	COG2922	Belongs to the Smg family
AMD12_RS19670	COG1754	DNA topoisomerase type I activity
AMD12_RS19670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMD12_RS19675	COG0009	L-threonylcarbamoyladenylate synthase
AMD12_RS19690	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS19700	COG0616	signal peptide processing
AMD12_RS19705	COG0534	Mate efflux family protein
AMD12_RS19725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AMD12_RS19730	COG0625	glutathione transferase activity
AMD12_RS19745	COG1252	NADH dehydrogenase
AMD12_RS19750	COG2860	membrane
AMD12_RS19755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMD12_RS19760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMD12_RS19765	COG2201	protein-glutamate methylesterase activity
AMD12_RS19770	COG2177	Part of the ABC transporter FtsEX involved in
AMD12_RS19775	COG2884	Cell division ATP-binding protein ftsE
AMD12_RS19780	COG0513	Belongs to the DEAD box helicase family
AMD12_RS19785	COG3118	belongs to the thioredoxin family
AMD12_RS19790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AMD12_RS19795	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AMD12_RS19800	COG0583	DNA-binding transcription factor activity
AMD12_RS19845	COG1518	maintenance of DNA repeat elements
AMD12_RS19850	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AMD12_RS19860	COG1652	LysM domain
AMD12_RS19865	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AMD12_RS19865	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AMD12_RS19870	COG1473	amidohydrolase
AMD12_RS19875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD12_RS19880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD12_RS19890	COG5383	Protein conserved in bacteria
AMD12_RS19930	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AMD12_RS19935	COG3023	N-Acetylmuramoyl-L-alanine amidase
AMD12_RS19945	COG4948	Mandelate Racemase Muconate Lactonizing
AMD12_RS19955	COG0531	amino acid
AMD12_RS19970	COG4682	membrane
AMD12_RS19975	COG2133	pyrroloquinoline quinone binding
AMD12_RS19985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AMD12_RS19990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMD12_RS20000	COG1610	YqeY-like protein
AMD12_RS20005	COG1295	ribonuclease BN
AMD12_RS20010	COG0358	DNA primase activity
AMD12_RS20025	COG0109	protoheme IX farnesyltransferase activity
AMD12_RS20055	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AMD12_RS20065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AMD12_RS20110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMD12_RS20115	COG0739	heme binding
AMD12_RS20120	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AMD12_RS20130	COG2223	nitrite transmembrane transporter activity
AMD12_RS20135	COG0708	Exodeoxyribonuclease III
AMD12_RS20140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMD12_RS20150	COG1192	Involved in chromosome partitioning
AMD12_RS20155	COG1475	DNA binding
AMD12_RS20170	COG0463	Glycosyl transferase, family 2
AMD12_RS20190	COG0756	dUTP diphosphatase activity
AMD12_RS20195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMD12_RS20200	COG2003	Belongs to the UPF0758 family
AMD12_RS20205	COG0018	arginyl-trna synthetase
AMD12_RS20220	COG4221	oxidoreductase activity
AMD12_RS20225	COG2755	lipolytic protein G-D-S-L family
AMD12_RS20225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMD12_RS20235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD12_RS20245	COG1166	arginine decarboxylase activity
AMD12_RS20250	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AMD12_RS20290	COG0606	chelatase, subunit chli
AMD12_RS20385	COG0606	chelatase, subunit chli
AMD12_RS20400	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AMD12_RS20435	COG1690	Belongs to the RtcB family
AMD12_RS20475	COG1090	epimerase
AMD12_RS20485	COG0642	Histidine kinase
AMD12_RS20505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD12_RS20530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMD12_RS20535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMD12_RS20550	COG0753	catalase activity
AMD12_RS20565	COG2197	response regulator
AMD12_RS20570	COG4585	Histidine kinase
AMD12_RS20575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD12_RS20580	COG1136	(ABC) transporter
AMD12_RS20605	COG0697	spore germination
AMD12_RS20620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD12_RS20625	COG0180	Tryptophanyl-tRNA synthetase
AMD12_RS20630	COG3237	CsbD-like
AMD12_RS20670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMD12_RS20685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMD12_RS20730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMD12_RS20750	COG1199	ATP-dependent helicase activity
AMD12_RS20765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMD12_RS20825	COG0625	glutathione transferase activity
AMD12_RS20865	COG4555	ABC transporter
AMD12_RS20875	COG1476	TRANSCRIPTIONal
AMD12_RS20920	COG0543	2 iron, 2 sulfur cluster binding
AMD12_RS20920	COG0633	Ferredoxin
AMD12_RS20925	COG1131	(ABC) transporter
AMD12_RS20930	COG0842	Transport permease protein
AMD12_RS20940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMD12_RS20970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD12_RS20975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD12_RS20985	COG0045	succinate-CoA ligase (ADP-forming) activity
AMD12_RS20985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMD12_RS20985	COG1042	CoA-binding domain protein
AMD12_RS20990	COG2239	Acts as a magnesium transporter
AMD12_RS20995	COG3338	carbonate dehydratase activity
AMD12_RS21005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AMD12_RS21010	COG3387	PFAM Glycoside hydrolase 15-related
AMD12_RS21025	COG3100	YcgL domain-containing protein
AMD12_RS21030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMD12_RS21040	COG0463	Glycosyl transferase, family 2
AMD12_RS21055	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS21095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD12_RS21110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMD12_RS21135	COG4946	Tricorn protease homolog
AMD12_RS21135	COG0823	Involved in the tonB-independent uptake of proteins
AMD12_RS21135	COG1506	peptidase
AMD12_RS21150	COG0408	coproporphyrinogen oxidase activity
AMD12_RS21185	COG2815	serine threonine protein kinase
AMD12_RS21185	COG0515	serine threonine protein kinase
AMD12_RS21190	COG0631	protein serine/threonine phosphatase activity
AMD12_RS21350	COG0210	DNA helicase
AMD12_RS21365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD12_RS21370	COG0583	DNA-binding transcription factor activity
AMD12_RS21375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMD12_RS21385	COG2159	amidohydrolase
AMD12_RS21405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD12_RS21425	COG0357	Ribosomal RNA small subunit methyltransferase G
AMD12_RS21430	COG3540	Alkaline phosphatase
AMD12_RS21440	COG2091	lysine biosynthetic process via aminoadipic acid
AMD12_RS21460	COG0708	Exodeoxyribonuclease III
AMD12_RS21465	COG1846	Transcriptional regulator
AMD12_RS21465	COG1940	carbohydrate kinase activity
AMD12_RS21475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD12_RS21485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMD12_RS21490	COG3162	membrane
AMD12_RS21500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMD12_RS21530	COG3507	Belongs to the glycosyl hydrolase 43 family
AMD12_RS21550	COG1028	Short-chain dehydrogenase reductase Sdr
AMD12_RS21555	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMD12_RS21560	COG4948	Mandelate Racemase Muconate Lactonizing
AMD12_RS21570	COG3254	rhamnose metabolic process
AMD12_RS21575	COG0738	Major facilitator superfamily
AMD12_RS21580	COG1414	Transcriptional regulator
AMD12_RS21585	COG1971	Probably functions as a manganese efflux pump
AMD12_RS21590	COG2205	protein histidine kinase activity
AMD12_RS21605	COG3459	Glycosyltransferase 36 associated
AMD12_RS21610	COG2211	Major facilitator Superfamily
AMD12_RS21615	COG3265	gluconokinase activity
AMD12_RS21620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD12_RS21640	COG2911	Protein conserved in bacteria
AMD12_RS21645	COG0729	surface antigen
AMD12_RS21685	COG0752	glycyl-tRNA synthetase alpha subunit
AMD12_RS21690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD12_RS21700	COG0519	Catalyzes the synthesis of GMP from XMP
AMD12_RS21700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD12_RS21710	COG0805	protein transport
AMD12_RS21715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMD12_RS21720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMD12_RS21730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AMD12_RS21750	COG2974	May be involved in recombination
AMD12_RS21755	COG0037	tRNA processing
AMD12_RS21760	COG2115	Belongs to the xylose isomerase family
AMD12_RS21770	COG3661	Belongs to the glycosyl hydrolase 67 family
AMD12_RS21780	COG4948	Mandelate Racemase Muconate Lactonizing
AMD12_RS21790	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD12_RS21795	COG0246	Mannitol dehydrogenase
AMD12_RS21870	COG3386	PFAM SMP-30 Gluconolaconase
AMD12_RS21880	COG3250	beta-galactosidase activity
AMD12_RS21885	COG1904	glucuronate isomerase
AMD12_RS21890	COG3693	PFAM glycoside hydrolase, family 10
AMD12_RS21905	COG3693	PFAM glycoside hydrolase, family 10
AMD12_RS21920	COG2211	Major facilitator Superfamily
AMD12_RS21965	COG2937	Belongs to the GPAT DAPAT family
AMD12_RS22000	COG0284	orotidine-5'-phosphate decarboxylase activity
AMD12_RS22005	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AMD12_RS22010	COG3132	Protein of unknown function, DUF480
AMD12_RS22025	COG0210	DNA helicase
AMD12_RS22030	COG1435	thymidine kinase activity
AMD12_RS22040	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AMD12_RS22050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMD12_RS22085	COG3135	benzoate transporter
AMD12_RS22105	COG0676	glucose-6-phosphate 1-epimerase activity
AMD12_RS22115	COG3012	SEC-C Motif Domain Protein
AMD12_RS22120	COG0730	response to heat
AMD12_RS22140	COG0302	gtp cyclohydrolase
AMD12_RS22155	COG1566	PFAM secretion protein HlyD family protein
AMD12_RS22165	COG1289	transmembrane transporter activity
AMD12_RS22170	COG0477	Major facilitator Superfamily
AMD12_RS22180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD12_RS22200	COG4691	Plasmid stability protein
AMD12_RS22205	COG1487	ribonuclease activity
AMD12_RS22230	COG0564	pseudouridine synthase activity
AMD12_RS22265	COG0439	Biotin carboxylase
AMD12_RS22305	COG1074	ATP-dependent DNA helicase activity
AMD12_RS22310	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AMD12_RS22325	COG1127	ABC transporter
AMD12_RS22330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMD12_RS22335	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMD12_RS22350	COG2853	Lipoprotein
AMD12_RS22360	COG0386	Belongs to the glutathione peroxidase family
AMD12_RS22370	COG1322	Protein conserved in bacteria
AMD12_RS22375	COG0604	alcohol dehydrogenase
AMD12_RS22390	COG0625	glutathione transferase activity
AMD12_RS22400	COG0531	amino acid
AMD12_RS22405	COG3537	Alpha-1,2-mannosidase
AMD12_RS22415	COG3706	GGDEF domain
AMD12_RS22420	COG3835	regulator
AMD12_RS22425	COG1929	Belongs to the glycerate kinase type-1 family
AMD12_RS22430	COG2271	Major facilitator Superfamily
AMD12_RS22445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AMD12_RS22450	COG0861	Integral membrane protein TerC family
AMD12_RS22460	COG0584	glycerophosphoryl diester phosphodiesterase
AMD12_RS22475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AMD12_RS22480	COG0726	polysaccharide deacetylase
AMD12_RS22490	COG0706	membrane insertase activity
AMD12_RS22495	COG0594	ribonuclease P activity