locus-tag	class	description
AMD11_RS00045	COG0187	DNA topoisomerase II activity
AMD11_RS00085	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMD11_RS00280	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD11_RS00325	COG0493	'glutamate synthase
AMD11_RS00340	COG0070	glutamate synthase
AMD11_RS00340	COG0069	glutamate synthase activity
AMD11_RS00340	COG0067	glutamate synthase
AMD11_RS00350	COG0070	glutamate synthase
AMD11_RS00350	COG0069	glutamate synthase activity
AMD11_RS00350	COG0067	glutamate synthase
AMD11_RS00450	COG0367	asparagine synthase
AMD11_RS00470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AMD11_RS00480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMD11_RS00485	COG0187	DNA topoisomerase II activity
AMD11_RS00495	COG0501	Belongs to the peptidase M48B family
AMD11_RS00525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMD11_RS00535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD11_RS00580	COG0793	Belongs to the peptidase S41A family
AMD11_RS00585	COG4942	peptidase
AMD11_RS00595	COG2234	aminopeptidase activity
AMD11_RS00605	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD11_RS00610	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD11_RS00615	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD11_RS00620	COG1064	alcohol dehydrogenase
AMD11_RS00625	COG0493	'glutamate synthase
AMD11_RS00630	COG0070	glutamate synthase
AMD11_RS00630	COG0069	glutamate synthase activity
AMD11_RS00630	COG0067	glutamate synthase
AMD11_RS00675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AMD11_RS00690	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AMD11_RS00695	COG0297	glycogen (starch) synthase activity
AMD11_RS00695	COG0438	transferase activity, transferring glycosyl groups
AMD11_RS00715	COG0367	asparagine synthase
AMD11_RS00745	COG1132	(ABC) transporter
AMD11_RS00775	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AMD11_RS00855	COG1205	dead DEAH box helicase
AMD11_RS00855	COG1111	helicase
AMD11_RS00860	COG1272	protein, Hemolysin III
AMD11_RS00875	COG0300	oxidoreductase activity
AMD11_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS00900	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMD11_RS00960	COG3237	CsbD-like
AMD11_RS01010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD11_RS01020	COG0477	Major facilitator Superfamily
AMD11_RS01060	COG0714	Associated with various cellular activities
AMD11_RS01090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AMD11_RS01100	COG4772	TonB-dependent receptor
AMD11_RS01110	COG0662	Cupin 2, conserved barrel domain protein
AMD11_RS01115	COG1012	belongs to the aldehyde dehydrogenase family
AMD11_RS01140	COG1304	FMN binding
AMD11_RS01155	COG4585	Histidine kinase
AMD11_RS01160	COG2197	response regulator
AMD11_RS01180	COG3710	Transcriptional regulator
AMD11_RS01185	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMD11_RS01255	COG2801	Transposase and inactivated derivatives
AMD11_RS01260	COG0366	Alpha amylase catalytic
AMD11_RS01265	COG0366	Alpha amylase catalytic
AMD11_RS01270	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMD11_RS01290	COG0657	acetylesterase activity
AMD11_RS01290	COG2755	lipolytic protein G-D-S-L family
AMD11_RS01300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMD11_RS01315	COG3507	Belongs to the glycosyl hydrolase 43 family
AMD11_RS01320	COG1609	Transcriptional regulator
AMD11_RS01325	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AMD11_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS01340	COG2755	lipolytic protein G-D-S-L family
AMD11_RS01355	COG3186	Phenylalanine-4-hydroxylase
AMD11_RS01360	COG1522	sequence-specific DNA binding
AMD11_RS01370	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMD11_RS01380	COG1119	ATPase activity
AMD11_RS01395	COG1125	glycine betaine transport
AMD11_RS01410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMD11_RS01430	COG1396	sequence-specific DNA binding
AMD11_RS01455	COG0489	protein tyrosine kinase activity
AMD11_RS01460	COG2062	phosphohistidine phosphatase, SixA
AMD11_RS01470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD11_RS01515	COG1968	undecaprenyl-diphosphatase activity
AMD11_RS01520	COG0174	glutamine synthetase
AMD11_RS01525	COG0347	Belongs to the P(II) protein family
AMD11_RS01530	COG0004	ammonium transporteR
AMD11_RS01535	COG3852	Histidine kinase
AMD11_RS01540	COG2204	response regulator
AMD11_RS01545	COG2032	superoxide dismutase activity
AMD11_RS01550	COG2032	superoxide dismutase activity
AMD11_RS01555	COG0346	lactoylglutathione lyase activity
AMD11_RS01565	COG0183	Belongs to the thiolase family
AMD11_RS01600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AMD11_RS01605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AMD11_RS01610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMD11_RS01620	COG0028	Belongs to the TPP enzyme family
AMD11_RS01625	COG2205	protein histidine kinase activity
AMD11_RS01650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AMD11_RS01665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD11_RS01675	COG0596	Alpha beta hydrolase
AMD11_RS01680	COG0727	PFAM Uncharacterised protein family (UPF0153)
AMD11_RS01685	COG0318	PFAM AMP-dependent synthetase and ligase
AMD11_RS01690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD11_RS01705	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMD11_RS01715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMD11_RS01725	COG0564	pseudouridine synthase activity
AMD11_RS01750	COG0339	signal peptide processing
AMD11_RS01780	COG0475	glutathione-regulated potassium exporter activity
AMD11_RS01785	COG0583	DNA-binding transcription factor activity
AMD11_RS01790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AMD11_RS01795	COG2224	Isocitrate lyase
AMD11_RS01825	COG4770	biotin carboxylase activity
AMD11_RS01830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMD11_RS01835	COG1960	acyl-CoA dehydrogenase activity
AMD11_RS01890	COG0523	cobalamin synthesis protein
AMD11_RS01905	COG0697	spore germination
AMD11_RS01915	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AMD11_RS01920	COG1846	Transcriptional regulator
AMD11_RS01925	COG1764	response to oxidative stress
AMD11_RS01955	COG2130	NADP-dependent
AMD11_RS01970	COG1187	pseudouridine synthase activity
AMD11_RS01985	COG1643	Atp-dependent helicase
AMD11_RS01995	COG4807	Protein conserved in bacteria
AMD11_RS02000	COG2351	hydroxyisourate hydrolase activity
AMD11_RS02005	COG2072	flavoprotein involved in K transport
AMD11_RS02025	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AMD11_RS02060	COG1957	nucleoside hydrolase
AMD11_RS02070	COG2252	PERMEase
AMD11_RS02095	COG0084	hydrolase, TatD family'
AMD11_RS02110	COG0583	DNA-binding transcription factor activity
AMD11_RS02115	COG2814	Major facilitator Superfamily
AMD11_RS02130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMD11_RS02135	COG1902	pentaerythritol trinitrate reductase activity
AMD11_RS02155	COG0745	RESPONSE REGULATOR receiver
AMD11_RS02160	COG2205	protein histidine kinase activity
AMD11_RS02165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD11_RS02185	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMD11_RS02190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMD11_RS02195	COG0583	DNA-binding transcription factor activity
AMD11_RS02225	COG0702	epimerase
AMD11_RS02230	COG1733	regulation of RNA biosynthetic process
AMD11_RS02255	COG2801	Transposase and inactivated derivatives
AMD11_RS02270	COG0129	dihydroxy-acid dehydratase activity
AMD11_RS02290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AMD11_RS02345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMD11_RS02350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AMD11_RS02375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMD11_RS02380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMD11_RS02390	COG3485	protocatechuate 3,4-dioxygenase
AMD11_RS02395	COG3485	protocatechuate 3,4-dioxygenase
AMD11_RS02405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD11_RS02410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMD11_RS02420	COG1414	Transcriptional regulator
AMD11_RS02430	COG0657	acetylesterase activity
AMD11_RS02440	COG0445	tRNA wobble uridine modification
AMD11_RS02450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMD11_RS02480	COG2267	carboxylic ester hydrolase activity
AMD11_RS02490	COG0156	8-amino-7-oxononanoate synthase activity
AMD11_RS02495	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AMD11_RS02500	COG1040	competence protein
AMD11_RS02505	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMD11_RS02580	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AMD11_RS02650	COG3264	Mechanosensitive ion channel
AMD11_RS02650	COG1511	domain protein
AMD11_RS02655	COG1368	sulfuric ester hydrolase activity
AMD11_RS02660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMD11_RS02665	COG2354	Protein conserved in bacteria
AMD11_RS02675	COG0297	glycogen (starch) synthase activity
AMD11_RS02680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMD11_RS02685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMD11_RS02710	COG0702	epimerase
AMD11_RS02715	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS02750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD11_RS02755	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS02765	COG0513	Belongs to the DEAD box helicase family
AMD11_RS02785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMD11_RS02795	COG3483	tryptophan 2,3-dioxygenase activity
AMD11_RS02800	COG3104	oligopeptide transport
AMD11_RS02820	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AMD11_RS02835	COG1320	monovalent cation:proton antiporter activity
AMD11_RS02840	COG2212	antiporter activity
AMD11_RS02850	COG0651	ATP synthesis coupled electron transport
AMD11_RS02855	COG1006	Multisubunit Na H antiporter MnhC subunit
AMD11_RS02860	COG2111	Na H antiporter
AMD11_RS02860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMD11_RS02880	COG3179	chitinase
AMD11_RS02900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMD11_RS02905	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AMD11_RS02920	COG0456	acetyltransferase
AMD11_RS02925	COG1597	lipid kinase activity
AMD11_RS02950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMD11_RS02955	COG0134	indole-3-glycerol-phosphate synthase activity
AMD11_RS02965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD11_RS02970	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMD11_RS02980	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AMD11_RS02990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMD11_RS03005	COG1051	belongs to the nudix hydrolase family
AMD11_RS03045	COG0316	Belongs to the HesB IscA family
AMD11_RS03070	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMD11_RS03090	COG2814	Major facilitator Superfamily
AMD11_RS03095	COG0583	DNA-binding transcription factor activity
AMD11_RS03100	COG2814	Major facilitator Superfamily
AMD11_RS03105	COG1289	transmembrane transporter activity
AMD11_RS03115	COG0151	Belongs to the GarS family
AMD11_RS03125	COG0138	bifunctional purine biosynthesis protein purh
AMD11_RS03130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD11_RS03135	COG2267	carboxylic ester hydrolase activity
AMD11_RS03140	COG2453	phosphatase
AMD11_RS03140	COG0671	phosphoesterase, PA-phosphatase related
AMD11_RS03165	COG4589	Belongs to the CDS family
AMD11_RS03170	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AMD11_RS03195	COG2264	protein methyltransferase activity
AMD11_RS03210	COG0439	Biotin carboxylase
AMD11_RS03220	COG0511	ligase activity, forming carbon-carbon bonds
AMD11_RS03225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMD11_RS03235	COG1324	tolerance protein
AMD11_RS03260	COG0300	oxidoreductase activity
AMD11_RS03265	COG2356	endonuclease I
AMD11_RS03275	COG0459	protein refolding
AMD11_RS03290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AMD11_RS03305	COG3386	PFAM SMP-30 Gluconolaconase
AMD11_RS03315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMD11_RS03320	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AMD11_RS03340	COG0778	Nitroreductase
AMD11_RS03345	COG2353	YceI-like domain
AMD11_RS03375	COG3052	prosthetic group binding
AMD11_RS03400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMD11_RS03410	COG1802	Transcriptional regulator
AMD11_RS03455	COG2801	Transposase and inactivated derivatives
AMD11_RS03465	COG4221	oxidoreductase activity
AMD11_RS03480	COG4221	oxidoreductase activity
AMD11_RS03490	COG0435	Glutathione S-transferase
AMD11_RS03515	COG2409	Drug exporters of the RND superfamily
AMD11_RS03520	COG0823	Involved in the tonB-independent uptake of proteins
AMD11_RS03520	COG1506	peptidase
AMD11_RS03560	COG0697	spore germination
AMD11_RS03575	COG1113	amino acid transport
AMD11_RS03595	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AMD11_RS03630	COG5001	Diguanylate cyclase
AMD11_RS03635	COG0840	transmembrane signaling receptor activity
AMD11_RS03640	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD11_RS03640	COG5297	Belongs to the glycosyl hydrolase family 6
AMD11_RS03645	COG0659	secondary active sulfate transmembrane transporter activity
AMD11_RS03670	COG2943	transferase activity, transferring hexosyl groups
AMD11_RS03680	COG3275	phosphorelay sensor kinase activity
AMD11_RS03690	COG0181	hydroxymethylbilane synthase activity
AMD11_RS03715	COG1505	serine-type exopeptidase activity
AMD11_RS03720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMD11_RS03725	COG0436	Aminotransferase
AMD11_RS03735	COG2832	Protein of unknown function (DUF454)
AMD11_RS03745	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AMD11_RS03755	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AMD11_RS03760	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AMD11_RS03765	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AMD11_RS03790	COG2226	methyltransferase
AMD11_RS03795	COG5001	Diguanylate cyclase
AMD11_RS03795	COG3300	MHYT domain
AMD11_RS03800	COG0308	aminopeptidase N
AMD11_RS03850	COG3284	Transcriptional regulator
AMD11_RS03855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD11_RS03860	COG1077	Cell shape determining protein MreB Mrl
AMD11_RS03865	COG1792	Involved in formation and maintenance of cell shape
AMD11_RS03880	COG0772	Belongs to the SEDS family
AMD11_RS03890	COG2951	lytic endotransglycosylase activity
AMD11_RS03895	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AMD11_RS03905	COG1686	Belongs to the peptidase S11 family
AMD11_RS03915	COG2921	Belongs to the UPF0250 family
AMD11_RS03920	COG0321	lipoyl(octanoyl) transferase activity
AMD11_RS03925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMD11_RS03940	COG0583	DNA-binding transcription factor activity
AMD11_RS03950	COG1051	belongs to the nudix hydrolase family
AMD11_RS03950	COG1056	cytidyltransferase-related domain
AMD11_RS03985	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AMD11_RS03990	COG0673	inositol 2-dehydrogenase activity
AMD11_RS03995	COG2823	Periplasmic or secreted lipoprotein
AMD11_RS04000	COG4251	negative regulation of phosphorylation
AMD11_RS04005	COG0784	Response regulator, receiver
AMD11_RS04010	COG4191	Histidine kinase
AMD11_RS04015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AMD11_RS04070	COG1459	type II secretion system
AMD11_RS04135	COG2188	Transcriptional regulator
AMD11_RS04145	COG1609	Transcriptional regulator
AMD11_RS04150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMD11_RS04155	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AMD11_RS04165	COG0617	tRNA 3'-terminal CCA addition
AMD11_RS04170	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AMD11_RS04175	COG1012	belongs to the aldehyde dehydrogenase family
AMD11_RS04180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AMD11_RS04190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMD11_RS04205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AMD11_RS04210	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AMD11_RS04225	COG2205	protein histidine kinase activity
AMD11_RS04255	COG3791	Glutathione-dependent formaldehyde-activating
AMD11_RS04270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMD11_RS04280	COG0697	spore germination
AMD11_RS04290	COG0488	(ABC) transporter
AMD11_RS04300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMD11_RS04305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMD11_RS04315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMD11_RS04315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMD11_RS04335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMD11_RS04340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMD11_RS04345	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AMD11_RS04365	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AMD11_RS04370	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AMD11_RS04375	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AMD11_RS04380	COG2205	protein histidine kinase activity
AMD11_RS04385	COG0745	RESPONSE REGULATOR receiver
AMD11_RS04400	COG0277	FAD linked oxidase domain protein
AMD11_RS04405	COG1988	membrane-bound metal-dependent
AMD11_RS04410	COG0792	nuclease activity
AMD11_RS04440	COG0275	rRNA processing
AMD11_RS04445	COG3116	cell division
AMD11_RS04455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMD11_RS04460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMD11_RS04465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMD11_RS04475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMD11_RS04480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMD11_RS04485	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMD11_RS04490	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AMD11_RS04505	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AMD11_RS04515	COG0739	heme binding
AMD11_RS04520	COG0653	protein targeting
AMD11_RS04525	COG0494	nUDIX hydrolase
AMD11_RS04535	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMD11_RS04545	COG3321	synthase
AMD11_RS04545	COG0604	alcohol dehydrogenase
AMD11_RS04545	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS04565	COG0366	Alpha amylase catalytic
AMD11_RS04595	COG2226	methyltransferase
AMD11_RS04600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AMD11_RS04610	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AMD11_RS04645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMD11_RS04655	COG4106	trans-aconitate 2-methyltransferase activity
AMD11_RS04660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMD11_RS04670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD11_RS04675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AMD11_RS04680	COG0667	Aldo Keto reductase
AMD11_RS04690	COG4771	TonB-dependent receptor
AMD11_RS04710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD11_RS04715	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AMD11_RS04725	COG2175	clavaminate synthase activity
AMD11_RS04735	COG4181	ATPase activity
AMD11_RS04750	COG0642	Histidine kinase
AMD11_RS04760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AMD11_RS04780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMD11_RS04785	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AMD11_RS04800	COG3829	transcription factor binding
AMD11_RS04810	COG1116	anion transmembrane transporter activity
AMD11_RS04815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD11_RS04825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD11_RS04830	COG0431	NADPH-dependent FMN reductase
AMD11_RS04855	COG0747	negative chemotaxis
AMD11_RS04865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMD11_RS04875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AMD11_RS04880	COG2967	ApaG domain
AMD11_RS04885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMD11_RS04890	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AMD11_RS04895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD11_RS04900	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AMD11_RS04910	COG0123	including yeast histone deacetylase and acetoin utilization protein
AMD11_RS04915	COG2096	Adenosyltransferase
AMD11_RS04925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD11_RS04930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD11_RS04960	COG3384	dioxygenase
AMD11_RS04965	COG0583	DNA-binding transcription factor activity
AMD11_RS04980	COG1024	Enoyl-CoA hydratase
AMD11_RS05000	COG3386	PFAM SMP-30 Gluconolaconase
AMD11_RS05010	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AMD11_RS05035	COG0697	spore germination
AMD11_RS05045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD11_RS05065	COG5002	protein histidine kinase activity
AMD11_RS05065	COG0784	Response regulator, receiver
AMD11_RS05065	COG2205	protein histidine kinase activity
AMD11_RS05070	COG2197	response regulator
AMD11_RS05080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMD11_RS05090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMD11_RS05095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD11_RS05100	COG0583	DNA-binding transcription factor activity
AMD11_RS05105	COG3634	alkyl hydroperoxide reductase activity
AMD11_RS05115	COG2890	protein-(glutamine-N5) methyltransferase activity
AMD11_RS05135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD11_RS05135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD11_RS05165	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AMD11_RS05195	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AMD11_RS05210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMD11_RS05215	COG1404	Belongs to the peptidase S8 family
AMD11_RS05220	COG1404	Belongs to the peptidase S8 family
AMD11_RS05225	COG1404	Belongs to the peptidase S8 family
AMD11_RS05230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMD11_RS05255	COG1295	ribonuclease BN
AMD11_RS05260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD11_RS05265	COG1254	Belongs to the acylphosphatase family
AMD11_RS05280	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMD11_RS05290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMD11_RS05295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AMD11_RS05305	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AMD11_RS05310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AMD11_RS05320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AMD11_RS05325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AMD11_RS05330	COG0193	aminoacyl-tRNA hydrolase activity
AMD11_RS05335	COG0012	GTP binding
AMD11_RS05355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMD11_RS05370	COG0250	Participates in transcription elongation, termination and antitermination
AMD11_RS05375	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMD11_RS05380	COG0081	regulation of translation
AMD11_RS05385	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMD11_RS05390	COG0222	ribosome binding
AMD11_RS05395	COG0085	RNA polymerase activity
AMD11_RS05400	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMD11_RS05405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMD11_RS05410	COG0049	tRNA binding
AMD11_RS05415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMD11_RS05420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMD11_RS05425	COG0051	transcription antitermination factor activity, RNA binding
AMD11_RS05430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMD11_RS05435	COG0088	Forms part of the polypeptide exit tunnel
AMD11_RS05440	COG0089	rRNA binding
AMD11_RS05445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMD11_RS05450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMD11_RS05460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMD11_RS05465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AMD11_RS05470	COG0255	Belongs to the universal ribosomal protein uL29 family
AMD11_RS05475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMD11_RS05485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AMD11_RS05490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMD11_RS05500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMD11_RS05505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMD11_RS05510	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AMD11_RS05520	COG1841	ribosomal large subunit assembly
AMD11_RS05525	COG0200	Binds to the 23S rRNA
AMD11_RS05530	COG0201	protein transport
AMD11_RS05555	COG0203	ribosomal protein L17
AMD11_RS05560	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AMD11_RS05575	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AMD11_RS05585	COG0154	amidase activity
AMD11_RS05595	COG1217	gtp-binding protein TYPA
AMD11_RS05600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMD11_RS05605	COG0039	L-malate dehydrogenase activity
AMD11_RS05610	COG0625	glutathione transferase activity
AMD11_RS05620	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMD11_RS05620	COG1902	pentaerythritol trinitrate reductase activity
AMD11_RS05625	COG0604	alcohol dehydrogenase
AMD11_RS05650	COG0156	8-amino-7-oxononanoate synthase activity
AMD11_RS05655	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AMD11_RS05660	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AMD11_RS05665	COG4208	sulfate ABC transporter
AMD11_RS05670	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AMD11_RS05680	COG1063	alcohol dehydrogenase
AMD11_RS05710	COG0406	alpha-ribazole phosphatase activity
AMD11_RS05715	COG0285	dihydrofolate synthase activity
AMD11_RS05735	COG2833	Protein of unknown function (DUF455)
AMD11_RS05745	COG3291	Pkd domain containing protein
AMD11_RS05755	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD11_RS05760	COG0671	phosphoesterase, PA-phosphatase related
AMD11_RS05765	COG0438	transferase activity, transferring glycosyl groups
AMD11_RS05775	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AMD11_RS05790	COG4783	chaperone-mediated protein folding
AMD11_RS05805	COG0473	3-isopropylmalate dehydrogenase activity
AMD11_RS05935	COG2801	Transposase and inactivated derivatives
AMD11_RS05950	COG3852	Histidine kinase
AMD11_RS05960	COG0544	peptidyl-prolyl cis-trans isomerase activity
AMD11_RS05970	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMD11_RS06000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD11_RS06010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD11_RS06020	COG0328	RNA-DNA hybrid ribonuclease activity
AMD11_RS06025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD11_RS06030	COG0631	protein serine/threonine phosphatase activity
AMD11_RS06045	COG0859	PFAM glycosyl transferase family 9
AMD11_RS06050	COG3642	lipopolysaccharide core region biosynthetic process
AMD11_RS06055	COG1234	tRNA 3'-trailer cleavage
AMD11_RS06060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMD11_RS06070	COG0315	cyclic pyranopterin monophosphate synthase activity
AMD11_RS06075	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AMD11_RS06080	COG0314	molybdopterin synthase activity
AMD11_RS06135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMD11_RS06140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMD11_RS06145	COG0537	adenosine 5'-monophosphoramidase activity
AMD11_RS06165	COG0714	Associated with various cellular activities
AMD11_RS06185	COG0424	maF-like protein
AMD11_RS06190	COG1399	metal-binding, possibly nucleic acid-binding protein
AMD11_RS06195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMD11_RS06200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD11_RS06215	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS06230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMD11_RS06235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMD11_RS06260	COG3829	transcription factor binding
AMD11_RS06280	COG3609	addiction module antidote protein, CC2985 family
AMD11_RS06300	COG2373	Large extracellular alpha-helical protein
AMD11_RS06315	COG4953	penicillin-binding protein 1C
AMD11_RS06325	COG0678	peroxiredoxin activity
AMD11_RS06345	COG0330	HflC and HflK could
AMD11_RS06350	COG0330	HflC and HflK could
AMD11_RS06360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMD11_RS06365	COG0308	aminopeptidase N
AMD11_RS06375	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS06380	COG1309	transcriptional regulator
AMD11_RS06450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMD11_RS06460	COG3387	PFAM Glycoside hydrolase 15-related
AMD11_RS06465	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS06470	COG3537	Alpha-1,2-mannosidase
AMD11_RS06490	COG0492	ferredoxin-NADP+ reductase activity
AMD11_RS06515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMD11_RS06520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMD11_RS06525	COG2080	2 iron, 2 sulfur cluster binding
AMD11_RS06560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMD11_RS06575	COG0587	DNA-directed DNA polymerase activity
AMD11_RS06590	COG1297	OPT oligopeptide transporter protein
AMD11_RS06605	COG0823	Involved in the tonB-independent uptake of proteins
AMD11_RS06605	COG1506	peptidase
AMD11_RS06620	COG1917	Cupin 2, conserved barrel domain protein
AMD11_RS06620	COG2207	Transcriptional regulator
AMD11_RS06635	COG0753	catalase activity
AMD11_RS06640	COG0656	L-ascorbic acid biosynthetic process
AMD11_RS06650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMD11_RS06650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMD11_RS06655	COG2814	Major facilitator Superfamily
AMD11_RS06670	COG2194	sulfuric ester hydrolase activity
AMD11_RS06685	COG0745	RESPONSE REGULATOR receiver
AMD11_RS06690	COG0642	Histidine kinase
AMD11_RS06700	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AMD11_RS06705	COG2894	cell division
AMD11_RS06710	COG0850	regulation of cytokinetic process
AMD11_RS06725	COG4585	Histidine kinase
AMD11_RS06730	COG2197	response regulator
AMD11_RS06745	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AMD11_RS06770	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AMD11_RS06780	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AMD11_RS06800	COG1946	Acyl-CoA thioesterase
AMD11_RS06815	COG0824	Thioesterase
AMD11_RS06820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMD11_RS06825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMD11_RS06830	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMD11_RS06835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMD11_RS06840	COG0268	Binds directly to 16S ribosomal RNA
AMD11_RS06850	COG0196	riboflavin kinase activity
AMD11_RS06855	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMD11_RS06860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMD11_RS06865	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMD11_RS06880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMD11_RS06885	COG1845	cytochrome c oxidase, subunit III
AMD11_RS06890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AMD11_RS06905	COG3152	Membrane
AMD11_RS06915	COG2207	Transcriptional regulator
AMD11_RS06920	COG0326	Molecular chaperone. Has ATPase activity
AMD11_RS06930	COG1366	Belongs to the anti-sigma-factor antagonist family
AMD11_RS06935	COG1366	Belongs to the anti-sigma-factor antagonist family
AMD11_RS06940	COG2172	sigma factor antagonist activity
AMD11_RS06965	COG4771	TonB-dependent receptor
AMD11_RS06975	COG5507	3-demethylubiquinone-9 3-methyltransferase
AMD11_RS06980	COG2205	protein histidine kinase activity
AMD11_RS06990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AMD11_RS06995	COG2205	protein histidine kinase activity
AMD11_RS06995	COG4999	Histidine kinase
AMD11_RS06995	COG3850	Histidine kinase
AMD11_RS06995	COG3437	response regulator, receiver
AMD11_RS07000	COG0784	Response regulator, receiver
AMD11_RS07000	COG4191	Histidine kinase
AMD11_RS07030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMD11_RS07035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMD11_RS07045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMD11_RS07050	COG0228	four-way junction DNA binding
AMD11_RS07055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AMD11_RS07060	COG0336	Belongs to the RNA methyltransferase TrmD family
AMD11_RS07065	COG0335	large ribosomal subunit rRNA binding
AMD11_RS07095	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMD11_RS07105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AMD11_RS07115	COG3209	COG3209 Rhs family protein
AMD11_RS07135	COG3250	beta-galactosidase activity
AMD11_RS07140	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AMD11_RS07160	COG1960	acyl-CoA dehydrogenase activity
AMD11_RS07165	COG1024	Enoyl-CoA hydratase
AMD11_RS07185	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD11_RS07185	COG1024	Enoyl-CoA hydratase
AMD11_RS07200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD11_RS07205	COG0481	GTPase activity
AMD11_RS07220	COG0571	ribonuclease III activity
AMD11_RS07225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMD11_RS07230	COG1381	Involved in DNA repair and RecF pathway recombination
AMD11_RS07240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMD11_RS07245	COG2954	triphosphatase activity
AMD11_RS07250	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMD11_RS07255	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AMD11_RS07260	COG3046	protein related to deoxyribodipyrimidine photolyase
AMD11_RS07265	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD11_RS07270	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AMD11_RS07275	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AMD11_RS07280	COG1278	Cold shock
AMD11_RS07285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD11_RS07295	COG1201	RNA secondary structure unwinding
AMD11_RS07300	COG1793	dna ligase
AMD11_RS07310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AMD11_RS07310	COG1793	dna ligase
AMD11_RS07340	COG0183	Belongs to the thiolase family
AMD11_RS07360	COG1451	nucleotide metabolic process
AMD11_RS07365	COG5487	UPF0391 membrane protein
AMD11_RS07375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AMD11_RS07395	COG1077	Cell shape determining protein MreB Mrl
AMD11_RS07400	COG1047	Peptidyl-prolyl cis-trans
AMD11_RS07410	COG2824	Alkylphosphonate utilization operon protein PhnA
AMD11_RS07415	COG1902	pentaerythritol trinitrate reductase activity
AMD11_RS07420	COG2814	Major facilitator Superfamily
AMD11_RS07455	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMD11_RS07455	COG0392	lysyltransferase activity
AMD11_RS07465	COG0251	oxidation-reduction process
AMD11_RS07470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMD11_RS07485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMD11_RS07510	COG1595	DNA-templated transcription, initiation
AMD11_RS07530	COG2878	Part of a membrane complex involved in electron transport
AMD11_RS07540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD11_RS07540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD11_RS07555	COG1131	(ABC) transporter
AMD11_RS07560	COG0346	lactoylglutathione lyase activity
AMD11_RS07565	COG0833	amino acid
AMD11_RS07570	COG2040	homocysteine
AMD11_RS07580	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AMD11_RS07600	COG1695	Transcriptional regulator
AMD11_RS07620	COG1981	membrane
AMD11_RS07635	COG0825	malonyl-CoA metabolic process
AMD11_RS07645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMD11_RS07650	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD11_RS07655	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD11_RS07660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD11_RS07665	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD11_RS07680	COG0750	zinc metalloprotease
AMD11_RS07685	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMD11_RS07690	COG0575	Belongs to the CDS family
AMD11_RS07695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMD11_RS07700	COG0233	cytoplasmic translational termination
AMD11_RS07705	COG0528	UMP kinase activity
AMD11_RS07715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMD11_RS07720	COG0052	Belongs to the universal ribosomal protein uS2 family
AMD11_RS07760	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AMD11_RS07770	COG1393	Belongs to the ArsC family
AMD11_RS07775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMD11_RS07780	COG0367	asparagine synthase
AMD11_RS07790	COG4774	siderophore transport
AMD11_RS07810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMD11_RS07840	COG1566	PFAM secretion protein HlyD family protein
AMD11_RS07845	COG2814	Major facilitator Superfamily
AMD11_RS07895	COG0339	signal peptide processing
AMD11_RS07900	COG0386	Belongs to the glutathione peroxidase family
AMD11_RS07955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AMD11_RS07960	COG0084	hydrolase, TatD family'
AMD11_RS07975	COG1960	acyl-CoA dehydrogenase activity
AMD11_RS07995	COG0367	asparagine synthase
AMD11_RS08005	COG0305	Participates in initiation and elongation during chromosome replication
AMD11_RS08010	COG0415	Belongs to the DNA photolyase family
AMD11_RS08020	COG0583	DNA-binding transcription factor activity
AMD11_RS08065	COG3706	GGDEF domain
AMD11_RS08170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMD11_RS08185	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD11_RS08195	COG0497	DNA recombination
AMD11_RS08200	COG1420	regulation of RNA biosynthetic process
AMD11_RS08205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMD11_RS08210	COG0443	Heat shock 70 kDa protein
AMD11_RS08215	COG0484	heat shock protein binding
AMD11_RS08220	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AMD11_RS08250	COG0583	DNA-binding transcription factor activity
AMD11_RS08255	COG1132	(ABC) transporter
AMD11_RS08290	COG2850	peptidyl-arginine hydroxylation
AMD11_RS08310	COG1253	flavin adenine dinucleotide binding
AMD11_RS08340	COG1131	(ABC) transporter
AMD11_RS08345	COG1725	Transcriptional regulator
AMD11_RS08350	COG0386	Belongs to the glutathione peroxidase family
AMD11_RS08365	COG2900	Belongs to the SlyX family
AMD11_RS08390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD11_RS08400	COG1410	methionine synthase
AMD11_RS08400	COG0646	methionine synthase
AMD11_RS08405	COG0646	methionine synthase
AMD11_RS08405	COG1410	methionine synthase
AMD11_RS08410	COG2226	methyltransferase
AMD11_RS08415	COG1960	acyl-CoA dehydrogenase activity
AMD11_RS08430	COG0557	exoribonuclease II activity
AMD11_RS08440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD11_RS08450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD11_RS08460	COG0704	Plays a role in the regulation of phosphate uptake
AMD11_RS08465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMD11_RS08470	COG0581	inorganic phosphate transmembrane transporter activity
AMD11_RS08475	COG0573	inorganic phosphate transmembrane transporter activity
AMD11_RS08480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AMD11_RS08505	COG0659	secondary active sulfate transmembrane transporter activity
AMD11_RS08510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMD11_RS08520	COG1024	Enoyl-CoA hydratase
AMD11_RS08530	COG0494	nUDIX hydrolase
AMD11_RS08565	COG0488	(ABC) transporter
AMD11_RS08570	COG0116	Belongs to the methyltransferase superfamily
AMD11_RS08570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AMD11_RS08575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMD11_RS08600	COG2925	Exonuclease
AMD11_RS08605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD11_RS08610	COG3844	kynureninase activity
AMD11_RS08620	COG0662	Cupin 2, conserved barrel domain protein
AMD11_RS08625	COG0288	reversible hydration of carbon dioxide
AMD11_RS08685	COG2808	Putative FMN-binding domain
AMD11_RS08705	COG0017	Asparaginyl-tRNA synthetase
AMD11_RS08710	COG0316	Belongs to the HesB IscA family
AMD11_RS08715	COG0360	Binds together with S18 to 16S ribosomal RNA
AMD11_RS08720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMD11_RS08725	COG0359	binds to the 23S rRNA
AMD11_RS08735	COG3115	cell septum assembly
AMD11_RS08745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMD11_RS08750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMD11_RS08755	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AMD11_RS08765	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMD11_RS08785	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AMD11_RS08795	COG2986	histidine ammonia-lyase
AMD11_RS08800	COG1228	amidohydrolase
AMD11_RS08845	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AMD11_RS08850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AMD11_RS08855	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AMD11_RS08860	COG0077	Prephenate dehydratase
AMD11_RS08860	COG1605	Chorismate mutase
AMD11_RS08865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMD11_RS08880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMD11_RS08885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMD11_RS08890	COG0583	DNA-binding transcription factor activity
AMD11_RS08925	COG2801	Transposase and inactivated derivatives
AMD11_RS08945	COG0840	transmembrane signaling receptor activity
AMD11_RS08980	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AMD11_RS08985	COG0784	Response regulator, receiver
AMD11_RS08985	COG4191	Histidine kinase
AMD11_RS09000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMD11_RS09010	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AMD11_RS09020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMD11_RS09035	COG1595	DNA-templated transcription, initiation
AMD11_RS09090	COG2244	polysaccharide biosynthetic process
AMD11_RS09120	COG2264	protein methyltransferase activity
AMD11_RS09130	COG0438	transferase activity, transferring glycosyl groups
AMD11_RS09145	COG1136	(ABC) transporter
AMD11_RS09155	COG0477	Major facilitator Superfamily
AMD11_RS09160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD11_RS09175	COG1253	flavin adenine dinucleotide binding
AMD11_RS09185	COG0306	phosphate transporter
AMD11_RS09210	COG0504	CTP synthase activity
AMD11_RS09215	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AMD11_RS09225	COG0148	phosphopyruvate hydratase activity
AMD11_RS09230	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AMD11_RS09235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMD11_RS09240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMD11_RS09245	COG0585	pseudouridine synthase activity
AMD11_RS09250	COG2840	Smr protein MutS2
AMD11_RS09255	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AMD11_RS09260	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMD11_RS09265	COG1238	metal cluster binding
AMD11_RS09280	COG1534	Rna-binding protein
AMD11_RS09285	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AMD11_RS09295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMD11_RS09300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMD11_RS09310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMD11_RS09315	COG1546	Belongs to the CinA family
AMD11_RS09325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMD11_RS09330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMD11_RS09335	COG2137	regulation of response to DNA damage stimulus
AMD11_RS09340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMD11_RS09345	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AMD11_RS09360	COG1741	Belongs to the pirin family
AMD11_RS09370	COG0583	DNA-binding transcription factor activity
AMD11_RS09395	COG0351	phosphomethylpyrimidine kinase
AMD11_RS09395	COG0352	thiamine-phosphate diphosphorylase activity
AMD11_RS09410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AMD11_RS09415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMD11_RS09430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMD11_RS09440	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMD11_RS09445	COG3734	2-keto-3-deoxy-galactonokinase
AMD11_RS09455	COG4948	Mandelate Racemase Muconate Lactonizing
AMD11_RS09460	COG0800	Aldolase
AMD11_RS09500	COG1501	Belongs to the glycosyl hydrolase 31 family
AMD11_RS09510	COG1070	Carbohydrate kinase
AMD11_RS09515	COG2115	Belongs to the xylose isomerase family
AMD11_RS09520	COG0477	Major facilitator Superfamily
AMD11_RS09530	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMD11_RS09535	COG1469	GTP cyclohydrolase I activity
AMD11_RS09555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMD11_RS09560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AMD11_RS09565	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AMD11_RS09570	COG0166	Belongs to the GPI family
AMD11_RS09590	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD11_RS09600	COG2203	Gaf domain
AMD11_RS09600	COG3706	GGDEF domain
AMD11_RS09600	COG4251	negative regulation of phosphorylation
AMD11_RS09600	COG5001	Diguanylate cyclase
AMD11_RS09605	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AMD11_RS09610	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AMD11_RS09620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AMD11_RS09625	COG0671	phosphoesterase, PA-phosphatase related
AMD11_RS09635	COG1794	racemase activity, acting on amino acids and derivatives
AMD11_RS09640	COG0697	spore germination
AMD11_RS09645	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMD11_RS09650	COG0167	dihydroorotate dehydrogenase activity
AMD11_RS09665	COG1012	belongs to the aldehyde dehydrogenase family
AMD11_RS09680	COG1215	transferase activity, transferring glycosyl groups
AMD11_RS09685	COG0726	polysaccharide deacetylase
AMD11_RS09685	COG1649	PFAM Uncharacterised BCR, COG1649
AMD11_RS09700	COG3210	domain, Protein
AMD11_RS09705	COG3210	domain, Protein
AMD11_RS09745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD11_RS09750	COG0124	histidyl-tRNA synthetase
AMD11_RS09760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMD11_RS09765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMD11_RS09770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMD11_RS09775	COG0131	Imidazoleglycerol-phosphate dehydratase
AMD11_RS09775	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AMD11_RS09780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMD11_RS09785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AMD11_RS09790	COG0107	imidazoleglycerol-phosphate synthase activity
AMD11_RS09795	COG0140	phosphoribosyl-ATP diphosphatase activity
AMD11_RS09795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMD11_RS09810	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AMD11_RS09815	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AMD11_RS09820	COG0235	Class ii aldolase
AMD11_RS09825	COG0531	amino acid
AMD11_RS09830	COG0531	amino acid
AMD11_RS09840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMD11_RS09845	COG0277	FAD linked oxidase domain protein
AMD11_RS09865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMD11_RS09910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMD11_RS09915	COG2258	MOSC domain
AMD11_RS09920	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMD11_RS09925	COG0505	Belongs to the CarA family
AMD11_RS09935	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AMD11_RS09940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD11_RS09950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMD11_RS09995	COG3279	Response regulator of the LytR AlgR family
AMD11_RS10000	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMD11_RS10005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMD11_RS10015	COG0784	Response regulator, receiver
AMD11_RS10015	COG2198	Histidine kinase
AMD11_RS10015	COG2205	protein histidine kinase activity
AMD11_RS10020	COG1024	Enoyl-CoA hydratase
AMD11_RS10025	COG0318	PFAM AMP-dependent synthetase and ligase
AMD11_RS10055	COG2267	carboxylic ester hydrolase activity
AMD11_RS10065	COG2201	protein-glutamate methylesterase activity
AMD11_RS10070	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AMD11_RS10080	COG0840	transmembrane signaling receptor activity
AMD11_RS10085	COG0840	transmembrane signaling receptor activity
AMD11_RS10090	COG0840	transmembrane signaling receptor activity
AMD11_RS10100	COG0840	transmembrane signaling receptor activity
AMD11_RS10105	COG0840	transmembrane signaling receptor activity
AMD11_RS10110	COG0840	transmembrane signaling receptor activity
AMD11_RS10115	COG0840	transmembrane signaling receptor activity
AMD11_RS10130	COG0840	transmembrane signaling receptor activity
AMD11_RS10145	COG0840	transmembrane signaling receptor activity
AMD11_RS10150	COG2198	Histidine kinase
AMD11_RS10150	COG0643	Histidine kinase
AMD11_RS10155	COG0745	RESPONSE REGULATOR receiver
AMD11_RS10165	COG0835	chemotaxis
AMD11_RS10175	COG1360	Flagellar Motor Protein
AMD11_RS10180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AMD11_RS10265	COG0641	radical SAM
AMD11_RS10280	COG2198	Histidine kinase
AMD11_RS10280	COG0784	Response regulator, receiver
AMD11_RS10280	COG0643	Histidine kinase
AMD11_RS10310	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AMD11_RS10340	COG1684	flagellar biosynthetic protein fliR
AMD11_RS10355	COG3190	flagellar
AMD11_RS10405	COG1677	Flagellar hook-basal body complex protein FliE
AMD11_RS10435	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS10440	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS10445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD11_RS10465	COG2201	protein-glutamate methylesterase activity
AMD11_RS10495	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AMD11_RS10500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AMD11_RS10505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AMD11_RS10515	COG3951	Flagellar rod assembly protein muramidase FlgJ
AMD11_RS10515	COG1705	Flagellar rod assembly protein muramidase FlgJ
AMD11_RS10520	COG1706	bacterial-type flagellum-dependent cell motility
AMD11_RS10525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AMD11_RS10535	COG4787	bacterial-type flagellum-dependent cell motility
AMD11_RS10545	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AMD11_RS10550	COG1558	bacterial-type flagellum-dependent cell motility
AMD11_RS10560	COG0835	chemotaxis
AMD11_RS10560	COG0784	Response regulator, receiver
AMD11_RS10580	COG5002	protein histidine kinase activity
AMD11_RS10610	COG2915	High frequency lysogenization protein hflD homolog
AMD11_RS10615	COG0482	sulfurtransferase activity
AMD11_RS10630	COG0542	response to heat
AMD11_RS10640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AMD11_RS10650	COG0492	ferredoxin-NADP+ reductase activity
AMD11_RS10655	COG1674	ftsk spoiiie
AMD11_RS10665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AMD11_RS10675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AMD11_RS10680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMD11_RS10690	COG0183	Belongs to the thiolase family
AMD11_RS10695	COG1024	Enoyl-CoA hydratase
AMD11_RS10695	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD11_RS10710	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMD11_RS10720	COG1426	Protein conserved in bacteria
AMD11_RS10730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD11_RS10735	COG1160	GTP binding
AMD11_RS10740	COG0303	'Molybdopterin
AMD11_RS10745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMD11_RS10780	COG0708	Exodeoxyribonuclease III
AMD11_RS10790	COG0303	'Molybdopterin
AMD11_RS10795	COG0746	molybdenum cofactor guanylyltransferase activity
AMD11_RS10810	COG1914	H( )-stimulated, divalent metal cation uptake system
AMD11_RS10825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AMD11_RS10830	COG0668	transmembrane transport
AMD11_RS10840	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AMD11_RS10855	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS10860	COG1183	phosphatidylcholine synthase activity
AMD11_RS10870	COG3243	poly(R)-hydroxyalkanoic acid synthase
AMD11_RS10885	COG0723	plastoquinol--plastocyanin reductase activity
AMD11_RS10885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD11_RS10895	COG2183	response to ionizing radiation
AMD11_RS10900	COG0784	Response regulator, receiver
AMD11_RS10900	COG2205	protein histidine kinase activity
AMD11_RS10965	COG0800	Aldolase
AMD11_RS10970	COG0129	dihydroxy-acid dehydratase activity
AMD11_RS10975	COG0363	glucosamine-6-phosphate deaminase activity
AMD11_RS10980	COG0837	glucose binding
AMD11_RS10985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AMD11_RS11005	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AMD11_RS11020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMD11_RS11025	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AMD11_RS11035	COG4591	ABC-type transport system involved in lipoprotein release permease component
AMD11_RS11040	COG1136	(ABC) transporter
AMD11_RS11055	COG0811	peptide transport
AMD11_RS11065	COG1132	(ABC) transporter
AMD11_RS11070	COG1663	tetraacyldisaccharide 4'-kinase activity
AMD11_RS11075	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AMD11_RS11080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMD11_RS11090	COG0322	excinuclease ABC activity
AMD11_RS11095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD11_RS11115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD11_RS11120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD11_RS11135	COG2801	Transposase and inactivated derivatives
AMD11_RS11145	COG0582	viral genome integration into host DNA
AMD11_RS11155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AMD11_RS11175	COG1054	Belongs to the UPF0176 family
AMD11_RS11185	COG1530	ribonuclease E activity
AMD11_RS11195	COG3064	Membrane
AMD11_RS11200	COG0428	transporter
AMD11_RS11210	COG2154	pterin-4-alpha-carbinolamine dehydratase
AMD11_RS11215	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AMD11_RS11215	COG0316	Belongs to the HesB IscA family
AMD11_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS11305	COG1238	metal cluster binding
AMD11_RS11340	COG3279	Response regulator of the LytR AlgR family
AMD11_RS11385	COG4566	intracellular signal transduction
AMD11_RS11395	COG5001	Diguanylate cyclase
AMD11_RS11410	COG3685	Protein conserved in bacteria
AMD11_RS11425	COG1648	precorrin-2 dehydrogenase activity
AMD11_RS11425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMD11_RS11440	COG2814	Major facilitator Superfamily
AMD11_RS11460	COG1335	isochorismatase
AMD11_RS11475	COG2197	response regulator
AMD11_RS11495	COG0583	DNA-binding transcription factor activity
AMD11_RS11500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMD11_RS11505	COG3002	Belongs to the UPF0753 family
AMD11_RS11520	COG1396	sequence-specific DNA binding
AMD11_RS11525	COG5489	Protein of unknown function (DUF736)
AMD11_RS11530	COG2003	Belongs to the UPF0758 family
AMD11_RS11555	COG0582	viral genome integration into host DNA
AMD11_RS11570	COG4774	siderophore transport
AMD11_RS11585	COG2336	PFAM SpoVT AbrB
AMD11_RS11610	COG4206	TonB-dependent receptor
AMD11_RS11630	COG2273	Hydrolase Family 16
AMD11_RS11630	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AMD11_RS11650	COG2274	protein secretion by the type I secretion system
AMD11_RS11700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMD11_RS11705	COG0270	DNA (cytosine-5-)-methyltransferase activity
AMD11_RS11755	COG4804	nuclease activity
AMD11_RS11775	COG5006	permease, DMT superfamily
AMD11_RS11790	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMD11_RS11800	COG3938	Belongs to the proline racemase family
AMD11_RS11815	COG2807	transmembrane transport
AMD11_RS11820	COG2207	Transcriptional regulator
AMD11_RS11970	COG0210	DNA helicase
AMD11_RS12050	COG2084	Dehydrogenase
AMD11_RS12070	COG2003	Belongs to the UPF0758 family
AMD11_RS12105	COG0582	viral genome integration into host DNA
AMD11_RS12110	COG0519	Catalyzes the synthesis of GMP from XMP
AMD11_RS12110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD11_RS12120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMD11_RS12130	COG0475	glutathione-regulated potassium exporter activity
AMD11_RS12130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMD11_RS12135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMD11_RS12145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMD11_RS12150	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AMD11_RS12160	COG0776	regulation of translation
AMD11_RS12165	COG0539	negative regulation of cytoplasmic translation
AMD11_RS12170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AMD11_RS12185	COG2957	Belongs to the agmatine deiminase family
AMD11_RS12190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD11_RS12215	COG0395	ABC-type sugar transport system, permease component
AMD11_RS12220	COG1175	transmembrane transport
AMD11_RS12250	COG2350	Protein conserved in bacteria
AMD11_RS12255	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AMD11_RS12260	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMD11_RS12265	COG1187	pseudouridine synthase activity
AMD11_RS12285	COG0436	Aminotransferase
AMD11_RS12290	COG4133	protoheme IX ABC transporter activity
AMD11_RS12310	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AMD11_RS12315	COG1138	Cytochrome C-type biogenesis protein
AMD11_RS12335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD11_RS12340	COG1278	Cold shock
AMD11_RS12345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AMD11_RS12350	COG4988	ABC transporter
AMD11_RS12360	COG1294	oxidase, subunit
AMD11_RS12385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AMD11_RS12390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AMD11_RS12400	COG0165	Argininosuccinate lyase
AMD11_RS12405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AMD11_RS12415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMD11_RS12420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMD11_RS12430	COG0137	argininosuccinate synthase activity
AMD11_RS12435	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMD11_RS12445	COG0215	cysteine-tRNA ligase activity
AMD11_RS12450	COG2166	iron-sulfur cluster assembly
AMD11_RS12470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AMD11_RS12475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMD11_RS12500	COG4302	ethanolamine ammonia-lyase activity
AMD11_RS12530	COG2963	transposase activity
AMD11_RS12550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMD11_RS12555	COG0402	S-adenosylhomocysteine deaminase activity
AMD11_RS12565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMD11_RS12570	COG1509	lysine 2,3-aminomutase activity
AMD11_RS12575	COG3300	MHYT domain
AMD11_RS12575	COG5001	Diguanylate cyclase
AMD11_RS12590	COG0483	inositol monophosphate 1-phosphatase activity
AMD11_RS12595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AMD11_RS12610	COG0488	(ABC) transporter
AMD11_RS12615	COG0513	Belongs to the DEAD box helicase family
AMD11_RS12620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMD11_RS12625	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AMD11_RS12635	COG0625	glutathione transferase activity
AMD11_RS12645	COG4681	YaeQ
AMD11_RS12650	COG2081	HI0933 family
AMD11_RS12660	COG0501	Belongs to the peptidase M48B family
AMD11_RS12665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD11_RS12670	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS12690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AMD11_RS12695	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMD11_RS12700	COG0802	atpase or kinase
AMD11_RS12705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AMD11_RS12705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMD11_RS12710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMD11_RS12715	COG1570	exodeoxyribonuclease VII activity
AMD11_RS12725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMD11_RS12905	COG0835	chemotaxis
AMD11_RS12910	COG0840	transmembrane signaling receptor activity
AMD11_RS12915	COG2094	Belongs to the DNA glycosylase MPG family
AMD11_RS12920	COG1201	RNA secondary structure unwinding
AMD11_RS12935	COG2969	positive regulation of protein catabolic process
AMD11_RS12940	COG0625	glutathione transferase activity
AMD11_RS12945	COG2857	Cytochrome c1
AMD11_RS12950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AMD11_RS12955	COG0723	plastoquinol--plastocyanin reductase activity
AMD11_RS12960	COG0741	lytic transglycosylase activity
AMD11_RS12975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMD11_RS12980	COG1702	phosphate starvation-inducible protein PhoH
AMD11_RS12990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMD11_RS13000	COG4535	Mg2 and Co2 transporter CorC
AMD11_RS13015	COG1012	belongs to the aldehyde dehydrogenase family
AMD11_RS13025	COG1177	transmembrane transport
AMD11_RS13030	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMD11_RS13035	COG3842	ATPase activity
AMD11_RS13055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AMD11_RS13070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMD11_RS13075	COG0174	glutamine synthetase
AMD11_RS13080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD11_RS13090	COG2703	oxygen carrier activity
AMD11_RS13095	COG0477	Major facilitator Superfamily
AMD11_RS13105	COG0243	molybdopterin cofactor binding
AMD11_RS13110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMD11_RS13115	COG2223	nitrite transmembrane transporter activity
AMD11_RS13120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMD11_RS13130	COG2733	membrane
AMD11_RS13135	COG5002	protein histidine kinase activity
AMD11_RS13135	COG2205	protein histidine kinase activity
AMD11_RS13135	COG0784	Response regulator, receiver
AMD11_RS13145	COG0477	Major facilitator Superfamily
AMD11_RS13150	COG2902	Dehydrogenase
AMD11_RS13160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD11_RS13165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD11_RS13170	COG1609	Transcriptional regulator
AMD11_RS13175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD11_RS13175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMD11_RS13180	COG1105	Belongs to the carbohydrate kinase PfkB family
AMD11_RS13185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMD11_RS13185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMD11_RS13220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMD11_RS13230	COG1862	Preprotein translocase
AMD11_RS13235	COG0343	queuine tRNA-ribosyltransferase activity
AMD11_RS13240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMD11_RS13280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AMD11_RS13285	COG3291	Pkd domain containing protein
AMD11_RS13295	COG0405	Gamma-glutamyltransferase
AMD11_RS13300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMD11_RS13315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMD11_RS13320	COG0742	ribosomal rna small subunit methyltransferase
AMD11_RS13325	COG0326	Molecular chaperone. Has ATPase activity
AMD11_RS13395	COG0531	amino acid
AMD11_RS13410	COG0006	proline dipeptidase activity
AMD11_RS13420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMD11_RS13435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD11_RS13440	COG3938	Belongs to the proline racemase family
AMD11_RS13450	COG0552	protein localization to endoplasmic reticulum
AMD11_RS13455	COG1194	a g-specific adenine glycosylase
AMD11_RS13460	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AMD11_RS13465	COG0784	Response regulator, receiver
AMD11_RS13465	COG4191	Histidine kinase
AMD11_RS13480	COG0322	excinuclease ABC activity
AMD11_RS13495	COG3040	lipid binding
AMD11_RS13505	COG1960	acyl-CoA dehydrogenase activity
AMD11_RS13515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AMD11_RS13535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD11_RS13540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD11_RS13545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMD11_RS13570	COG0438	transferase activity, transferring glycosyl groups
AMD11_RS13580	COG0438	transferase activity, transferring glycosyl groups
AMD11_RS13585	COG0438	transferase activity, transferring glycosyl groups
AMD11_RS13635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD11_RS13635	COG0072	phenylalanine-tRNA ligase activity
AMD11_RS13640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMD11_RS13655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AMD11_RS13660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMD11_RS13685	COG1082	Xylose isomerase domain protein TIM barrel
AMD11_RS13700	COG0366	Alpha amylase catalytic
AMD11_RS13705	COG2963	transposase activity
AMD11_RS13770	COG2948	multi-organism process
AMD11_RS13790	COG3505	Type IV secretory pathway VirD4
AMD11_RS13805	COG0556	nucleotide-excision repair
AMD11_RS13875	COG4695	Portal protein
AMD11_RS13920	COG3179	chitinase
AMD11_RS14015	COG3275	phosphorelay sensor kinase activity
AMD11_RS14020	COG1611	Belongs to the LOG family
AMD11_RS14030	COG2095	MarC family integral membrane protein
AMD11_RS14040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AMD11_RS14075	COG1185	polyribonucleotide nucleotidyltransferase activity
AMD11_RS14080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMD11_RS14085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMD11_RS14090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AMD11_RS14095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AMD11_RS14100	COG0195	Participates in both transcription termination and antitermination
AMD11_RS14105	COG0779	Required for maturation of 30S ribosomal subunits
AMD11_RS14115	COG1007	ATP synthesis coupled electron transport
AMD11_RS14140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD11_RS14145	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AMD11_RS14155	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AMD11_RS14160	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AMD11_RS14165	COG0649	NAD binding
AMD11_RS14170	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD11_RS14175	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD11_RS14180	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD11_RS14195	COG0149	triose-phosphate isomerase activity
AMD11_RS14200	COG0300	oxidoreductase activity
AMD11_RS14235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD11_RS14240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AMD11_RS14245	COG0159	tryptophan synthase activity
AMD11_RS14255	COG0133	tryptophan synthase activity
AMD11_RS14265	COG0135	phosphoribosylanthranilate isomerase activity
AMD11_RS14270	COG0101	tRNA pseudouridine synthase activity
AMD11_RS14290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AMD11_RS14295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMD11_RS14300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AMD11_RS14305	COG2890	protein-(glutamine-N5) methyltransferase activity
AMD11_RS14315	COG0688	phosphatidylethanolamine metabolic process
AMD11_RS14325	COG0433	COG0433 Predicted ATPase
AMD11_RS14330	COG0494	nUDIX hydrolase
AMD11_RS14345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD11_RS14350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMD11_RS14375	COG0717	Belongs to the dCTP deaminase family
AMD11_RS14380	COG0489	protein tyrosine kinase activity
AMD11_RS14400	COG3590	peptidase
AMD11_RS14405	COG3590	peptidase
AMD11_RS14425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMD11_RS14430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD11_RS14435	COG2311	Membrane
AMD11_RS14440	COG1047	Peptidyl-prolyl cis-trans
AMD11_RS14445	COG0791	NLP P60 protein
AMD11_RS14450	COG0791	NLP P60 protein
AMD11_RS14460	COG4106	trans-aconitate 2-methyltransferase activity
AMD11_RS14465	COG1301	dicarboxylic acid transport
AMD11_RS14470	COG1785	Belongs to the alkaline phosphatase family
AMD11_RS14475	COG0037	tRNA processing
AMD11_RS14480	COG1722	exodeoxyribonuclease VII activity
AMD11_RS14485	COG0142	geranyltranstransferase activity
AMD11_RS14490	COG4104	PAAR repeat-containing protein
AMD11_RS14500	COG0312	modulator of DNA gyrase
AMD11_RS14505	COG3028	Belongs to the UPF0307 family
AMD11_RS14510	COG0312	modulator of DNA gyrase
AMD11_RS14520	COG3164	Protein of unknown function
AMD11_RS14530	COG0424	maF-like protein
AMD11_RS14535	COG2968	Membrane
AMD11_RS14550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AMD11_RS14565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMD11_RS14580	COG0495	leucyl-tRNA aminoacylation
AMD11_RS14590	COG3118	belongs to the thioredoxin family
AMD11_RS14615	COG2155	Conserved Protein
AMD11_RS14660	COG1132	(ABC) transporter
AMD11_RS14685	COG1538	Outer membrane efflux protein
AMD11_RS14690	COG0745	RESPONSE REGULATOR receiver
AMD11_RS14695	COG5002	protein histidine kinase activity
AMD11_RS14695	COG5000	phosphorelay sensor kinase activity
AMD11_RS14700	COG0475	glutathione-regulated potassium exporter activity
AMD11_RS14710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMD11_RS14735	COG1187	pseudouridine synthase activity
AMD11_RS14740	COG5001	Diguanylate cyclase
AMD11_RS14740	COG5002	protein histidine kinase activity
AMD11_RS14855	COG0667	Aldo Keto reductase
AMD11_RS14860	COG2814	Major facilitator Superfamily
AMD11_RS14865	COG0583	DNA-binding transcription factor activity
AMD11_RS14875	COG2207	Transcriptional regulator
AMD11_RS14885	COG1309	transcriptional regulator
AMD11_RS14910	COG0735	belongs to the Fur family
AMD11_RS14915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD11_RS14940	COG4452	Inner membrane protein CreD
AMD11_RS14950	COG2205	protein histidine kinase activity
AMD11_RS14955	COG0745	RESPONSE REGULATOR receiver
AMD11_RS14960	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AMD11_RS14970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AMD11_RS15005	COG2198	Histidine kinase
AMD11_RS15005	COG0643	Histidine kinase
AMD11_RS15010	COG0840	transmembrane signaling receptor activity
AMD11_RS15015	COG0835	chemotaxis
AMD11_RS15020	COG2200	EAL domain
AMD11_RS15020	COG2202	Pas domain
AMD11_RS15020	COG2199	diguanylate cyclase activity
AMD11_RS15025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AMD11_RS15030	COG2201	protein-glutamate methylesterase activity
AMD11_RS15035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD11_RS15040	COG3590	peptidase
AMD11_RS15050	COG0588	phosphoglycerate mutase activity
AMD11_RS15055	COG1515	deoxyribonuclease V activity
AMD11_RS15065	COG1741	Belongs to the pirin family
AMD11_RS15080	COG1741	Belongs to the pirin family
AMD11_RS15085	COG1966	Carbon starvation protein
AMD11_RS15090	COG2879	small protein
AMD11_RS15145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMD11_RS15150	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMD11_RS15155	COG2080	2 iron, 2 sulfur cluster binding
AMD11_RS15165	COG2203	Gaf domain
AMD11_RS15165	COG3706	GGDEF domain
AMD11_RS15165	COG5001	Diguanylate cyclase
AMD11_RS15165	COG4251	negative regulation of phosphorylation
AMD11_RS15205	COG0629	single-stranded DNA binding
AMD11_RS15210	COG0142	geranyltranstransferase activity
AMD11_RS15220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMD11_RS15235	COG0527	aspartate kinase activity
AMD11_RS15240	COG0384	phenazine biosynthesis protein PhzF
AMD11_RS15245	COG0384	phenazine biosynthesis protein PhzF
AMD11_RS15255	COG1764	response to oxidative stress
AMD11_RS15260	COG0540	Belongs to the ATCase OTCase family
AMD11_RS15265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AMD11_RS15270	COG1678	Uncharacterized ACR, COG1678
AMD11_RS15280	COG0519	Catalyzes the synthesis of GMP from XMP
AMD11_RS15290	COG5297	Belongs to the glycosyl hydrolase family 6
AMD11_RS15305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AMD11_RS15320	COG0739	heme binding
AMD11_RS15340	COG0693	protein deglycase activity
AMD11_RS15350	COG1959	2 iron, 2 sulfur cluster binding
AMD11_RS15355	COG0719	Fe-S assembly protein
AMD11_RS15360	COG0396	ATPase activity
AMD11_RS15365	COG0719	Fe-S assembly protein
AMD11_RS15370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMD11_RS15380	COG2146	nitrite reductase [NAD(P)H] activity
AMD11_RS15385	COG4774	siderophore transport
AMD11_RS15390	COG3128	pkhd-type hydroxylase
AMD11_RS15415	COG1477	protein flavinylation
AMD11_RS15420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AMD11_RS15435	COG1555	photosystem II stabilization
AMD11_RS15440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMD11_RS15450	COG3178	'Phosphotransferase
AMD11_RS15455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMD11_RS15465	COG0628	permease
AMD11_RS15475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMD11_RS15485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AMD11_RS15505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMD11_RS15510	COG0271	Belongs to the BolA IbaG family
AMD11_RS15520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AMD11_RS15530	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AMD11_RS15535	COG1137	ATPase activity
AMD11_RS15550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD11_RS15555	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AMD11_RS15560	COG1660	Displays ATPase and GTPase activities
AMD11_RS15570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD11_RS15575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMD11_RS15580	COG2239	Acts as a magnesium transporter
AMD11_RS15590	COG1294	oxidase, subunit
AMD11_RS15595	COG1271	oxidase subunit
AMD11_RS15605	COG1113	amino acid transport
AMD11_RS15625	COG2197	response regulator
AMD11_RS15630	COG0531	amino acid
AMD11_RS15650	COG1234	tRNA 3'-trailer cleavage
AMD11_RS15685	COG2814	Major facilitator Superfamily
AMD11_RS15695	COG0754	glutathionylspermidine amidase activity
AMD11_RS15720	COG1842	Phage shock protein A
AMD11_RS15730	COG0259	pyridoxamine-phosphate oxidase activity
AMD11_RS15735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMD11_RS15740	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AMD11_RS15750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AMD11_RS15825	COG2814	Major facilitator Superfamily
AMD11_RS15845	COG0784	Response regulator, receiver
AMD11_RS15845	COG2205	protein histidine kinase activity
AMD11_RS15845	COG2198	Histidine kinase
AMD11_RS15850	COG2353	YceI-like domain
AMD11_RS15870	COG1760	l-serine dehydratase
AMD11_RS15880	COG0527	aspartate kinase activity
AMD11_RS15880	COG0460	homoserine dehydrogenase
AMD11_RS15885	COG0626	cystathionine gamma-synthase activity
AMD11_RS15890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD11_RS15895	COG0739	heme binding
AMD11_RS15900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AMD11_RS15905	COG1272	protein, Hemolysin III
AMD11_RS15910	COG2982	Protein involved in outer membrane biogenesis
AMD11_RS15915	COG0516	GMP reductase activity
AMD11_RS15915	COG0517	IMP dehydrogenase activity
AMD11_RS15920	COG0463	Glycosyl transferase, family 2
AMD11_RS15925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMD11_RS15930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AMD11_RS15940	COG4771	TonB-dependent receptor
AMD11_RS15950	COG1309	transcriptional regulator
AMD11_RS15960	COG1960	acyl-CoA dehydrogenase activity
AMD11_RS15985	COG0509	glycine decarboxylation via glycine cleavage system
AMD11_RS15990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMD11_RS16000	COG0330	HflC and HflK could
AMD11_RS16005	COG1742	UPF0060 membrane protein
AMD11_RS16010	COG3956	TIGRFAM MazG family protein
AMD11_RS16020	COG0494	nUDIX hydrolase
AMD11_RS16030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AMD11_RS16035	COG0837	glucose binding
AMD11_RS16050	COG3858	chitin binding
AMD11_RS16050	COG1388	LysM domain
AMD11_RS16055	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AMD11_RS16065	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD11_RS16080	COG0531	amino acid
AMD11_RS16090	COG1486	melibiose metabolic process
AMD11_RS16100	COG3537	Alpha-1,2-mannosidase
AMD11_RS16135	COG3142	Participates in the control of copper homeostasis
AMD11_RS16140	COG1446	asparaginase
AMD11_RS16165	COG0784	Response regulator, receiver
AMD11_RS16165	COG2198	Histidine kinase
AMD11_RS16165	COG0643	Histidine kinase
AMD11_RS16170	COG0840	transmembrane signaling receptor activity
AMD11_RS16175	COG0835	chemotaxis
AMD11_RS16190	COG0189	ligase activity
AMD11_RS16200	COG1397	ADP-ribosylglycohydrolase
AMD11_RS16210	COG1199	ATP-dependent helicase activity
AMD11_RS16220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMD11_RS16225	COG1215	transferase activity, transferring glycosyl groups
AMD11_RS16235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD11_RS16240	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMD11_RS16245	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AMD11_RS16250	COG0535	radical SAM domain protein
AMD11_RS16255	COG0535	radical SAM domain protein
AMD11_RS16270	COG0837	glucose binding
AMD11_RS16280	COG1643	Atp-dependent helicase
AMD11_RS16285	COG0783	Belongs to the Dps family
AMD11_RS16290	COG0514	ATP-dependent DNA helicase (RecQ)
AMD11_RS16325	COG0840	transmembrane signaling receptor activity
AMD11_RS16345	COG3920	Histidine kinase
AMD11_RS16350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AMD11_RS16360	COG0602	queuosine metabolic process
AMD11_RS16370	COG2885	chlorophyll binding
AMD11_RS16375	COG0823	Involved in the tonB-independent uptake of proteins
AMD11_RS16385	COG0848	biopolymer transport protein
AMD11_RS16395	COG0824	Thioesterase
AMD11_RS16400	COG2255	four-way junction helicase activity
AMD11_RS16410	COG3158	transport of potassium into the cell
AMD11_RS16415	COG0632	four-way junction helicase activity
AMD11_RS16420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMD11_RS16425	COG0217	transcriptional regulatory protein
AMD11_RS16440	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMD11_RS16455	COG0477	Major facilitator Superfamily
AMD11_RS16490	COG0488	(ABC) transporter
AMD11_RS16525	COG4651	solute:proton antiporter activity
AMD11_RS16525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMD11_RS16550	COG4772	TonB-dependent receptor
AMD11_RS16560	COG4264	IucA IucC family
AMD11_RS16575	COG0019	diaminopimelate decarboxylase activity
AMD11_RS16600	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AMD11_RS16610	COG1492	cobalamin metabolic process
AMD11_RS16620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMD11_RS16640	COG4206	TonB-dependent receptor
AMD11_RS16645	COG0542	response to heat
AMD11_RS16650	COG1116	anion transmembrane transporter activity
AMD11_RS16655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD11_RS16660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMD11_RS16665	COG0667	Aldo Keto reductase
AMD11_RS16670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD11_RS16675	COG4771	TonB-dependent receptor
AMD11_RS16680	COG2827	Endonuclease containing a URI domain
AMD11_RS16720	COG1877	trehalose-phosphatase activity
AMD11_RS16725	COG3387	PFAM Glycoside hydrolase 15-related
AMD11_RS16740	COG0840	transmembrane signaling receptor activity
AMD11_RS16745	COG3011	Protein conserved in bacteria
AMD11_RS16760	COG0564	pseudouridine synthase activity
AMD11_RS16765	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD11_RS16775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD11_RS16775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AMD11_RS16805	COG2951	lytic endotransglycosylase activity
AMD11_RS16810	COG4644	lycopene metabolic process
AMD11_RS16830	COG2369	cell adhesion
AMD11_RS16850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AMD11_RS16855	COG0045	succinate-CoA ligase (ADP-forming) activity
AMD11_RS16870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD11_RS16900	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AMD11_RS16905	COG0237	dephospho-CoA kinase activity
AMD11_RS16925	COG2801	Transposase and inactivated derivatives
AMD11_RS16930	COG5002	protein histidine kinase activity
AMD11_RS16935	COG0745	RESPONSE REGULATOR receiver
AMD11_RS16945	COG0189	ligase activity
AMD11_RS17005	COG2003	Belongs to the UPF0758 family
AMD11_RS17030	COG0784	Response regulator, receiver
AMD11_RS17030	COG4191	Histidine kinase
AMD11_RS17035	COG4191	Histidine kinase
AMD11_RS17035	COG0784	Response regulator, receiver
AMD11_RS17145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMD11_RS17170	COG2022	thiamine diphosphate biosynthetic process
AMD11_RS17175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMD11_RS17180	COG0471	metal ion transport
AMD11_RS17180	COG3273	potassium ion transport
AMD11_RS17200	COG1970	mechanosensitive ion channel activity
AMD11_RS17225	COG3250	beta-galactosidase activity
AMD11_RS17230	COG4948	Mandelate Racemase Muconate Lactonizing
AMD11_RS17245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD11_RS17255	COG0308	aminopeptidase N
AMD11_RS17305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD11_RS17315	COG0529	Catalyzes the synthesis of activated sulfate
AMD11_RS17315	COG2895	sulfate adenylyltransferase (ATP) activity
AMD11_RS17320	COG0175	sulfate reduction
AMD11_RS17325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AMD11_RS17330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMD11_RS17335	COG0175	sulfate reduction
AMD11_RS17355	COG0784	Response regulator, receiver
AMD11_RS17355	COG2205	protein histidine kinase activity
AMD11_RS17355	COG2198	Histidine kinase
AMD11_RS17390	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AMD11_RS17395	COG3588	fructose-bisphosphate aldolase
AMD11_RS17400	COG0469	pyruvate kinase activity
AMD11_RS17410	COG0126	phosphoglycerate kinase activity
AMD11_RS17430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AMD11_RS17440	COG3047	cAMP biosynthetic process
AMD11_RS17445	COG3047	cAMP biosynthetic process
AMD11_RS17455	COG3453	Protein conserved in bacteria
AMD11_RS17455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD11_RS17460	COG0725	ABC transporter, periplasmic molybdate-binding protein
AMD11_RS17465	COG4149	molybdate abc transporter
AMD11_RS17470	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AMD11_RS17505	COG1376	ErfK ybiS ycfS ynhG family protein
AMD11_RS17510	COG0739	heme binding
AMD11_RS17520	COG4773	Receptor
AMD11_RS17535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AMD11_RS17540	COG1301	dicarboxylic acid transport
AMD11_RS17550	COG2304	oxidoreductase activity
AMD11_RS17570	COG0714	Associated with various cellular activities
AMD11_RS17600	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AMD11_RS17625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AMD11_RS17635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD11_RS17645	COG0194	GDP metabolic process
AMD11_RS17650	COG1561	YicC-like family, N-terminal region
AMD11_RS17655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMD11_RS17665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMD11_RS17670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMD11_RS17685	COG0006	proline dipeptidase activity
AMD11_RS17695	COG0006	proline dipeptidase activity
AMD11_RS17700	COG3079	Belongs to the UPF0149 family
AMD11_RS17715	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMD11_RS17725	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AMD11_RS17735	COG2912	Transglutaminase-like superfamily
AMD11_RS17740	COG1773	rubredoxin
AMD11_RS17745	COG0352	thiamine-phosphate diphosphorylase activity
AMD11_RS17760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMD11_RS17775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMD11_RS17805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMD11_RS17810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD11_RS17815	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS17825	COG0671	phosphoesterase, PA-phosphatase related
AMD11_RS17830	COG3781	membrane
AMD11_RS17840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMD11_RS17845	COG0563	adenylate kinase activity
AMD11_RS17860	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AMD11_RS17870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMD11_RS17890	COG3710	Transcriptional regulator
AMD11_RS17895	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMD11_RS17905	COG0840	transmembrane signaling receptor activity
AMD11_RS17910	COG0405	Gamma-glutamyltransferase
AMD11_RS17915	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMD11_RS17935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMD11_RS17940	COG0473	3-isopropylmalate dehydrogenase activity
AMD11_RS17945	COG0066	3-isopropylmalate dehydratase activity
AMD11_RS17950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMD11_RS17970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMD11_RS17975	COG1538	Outer membrane efflux protein
AMD11_RS17980	COG1519	Transferase
AMD11_RS17985	COG1560	Kdo2-lipid A biosynthetic process
AMD11_RS18010	COG0281	malic enzyme
AMD11_RS18010	COG0280	phosphate acetyltransferase
AMD11_RS18015	COG1301	dicarboxylic acid transport
AMD11_RS18040	COG0583	DNA-binding transcription factor activity
AMD11_RS18045	COG0667	Aldo Keto reductase
AMD11_RS18060	COG2197	response regulator
AMD11_RS18070	COG0642	Histidine kinase
AMD11_RS18085	COG2851	Citrate transporter
AMD11_RS18090	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS18095	COG1609	Transcriptional regulator
AMD11_RS18100	COG2211	Major facilitator Superfamily
AMD11_RS18125	COG1162	GTPase activity
AMD11_RS18145	COG4773	Receptor
AMD11_RS18150	COG0726	polysaccharide deacetylase
AMD11_RS18155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AMD11_RS18170	COG2963	transposase activity
AMD11_RS18175	COG2801	Transposase and inactivated derivatives
AMD11_RS18190	COG1307	EDD domain protein, DegV family
AMD11_RS18195	COG0242	peptide deformylase activity
AMD11_RS18215	COG0457	Tetratricopeptide repeat
AMD11_RS18220	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AMD11_RS18225	COG1215	transferase activity, transferring glycosyl groups
AMD11_RS18230	COG1215	transferase activity, transferring glycosyl groups
AMD11_RS18245	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AMD11_RS18300	COG2188	Transcriptional regulator
AMD11_RS18310	COG1450	Type ii and iii secretion system protein
AMD11_RS18325	COG3166	PFAM Fimbrial assembly family protein
AMD11_RS18330	COG3156	type II secretion system protein K
AMD11_RS18335	COG4795	General secretion pathway protein
AMD11_RS18340	COG2165	general secretion pathway protein
AMD11_RS18345	COG4970	Tfp pilus assembly protein FimT
AMD11_RS18350	COG2165	general secretion pathway protein
AMD11_RS18355	COG1459	type II secretion system
AMD11_RS18360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD11_RS18365	COG1404	Belongs to the peptidase S8 family
AMD11_RS18370	COG5295	Hep Hag repeat protein
AMD11_RS18375	COG1404	Belongs to the peptidase S8 family
AMD11_RS18380	COG5295	Hep Hag repeat protein
AMD11_RS18390	COG0047	phosphoribosylformylglycinamidine synthase activity
AMD11_RS18390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMD11_RS18395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMD11_RS18400	COG4974	Belongs to the 'phage' integrase family
AMD11_RS18415	COG0795	lipopolysaccharide-transporting ATPase activity
AMD11_RS18425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMD11_RS18440	COG0525	valine-tRNA ligase activity
AMD11_RS18470	COG1183	phosphatidylcholine synthase activity
AMD11_RS18480	COG0442	prolyl-tRNA aminoacylation
AMD11_RS18495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMD11_RS18500	COG1127	ABC transporter
AMD11_RS18505	COG3218	ABC-type transport auxiliary lipoprotein component
AMD11_RS18505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMD11_RS18540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD11_RS18545	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AMD11_RS18545	COG0662	Cupin 2, conserved barrel domain protein
AMD11_RS18575	COG2086	electron transfer activity
AMD11_RS18590	COG0546	phosphoglycolate phosphatase activity
AMD11_RS18590	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMD11_RS18595	COG0277	FAD linked oxidase domain protein
AMD11_RS18610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD11_RS18640	COG1216	Glycosyl transferase, family 2
AMD11_RS18640	COG0438	transferase activity, transferring glycosyl groups
AMD11_RS18660	COG0626	cystathionine gamma-synthase activity
AMD11_RS18695	COG0625	glutathione transferase activity
AMD11_RS18705	COG0513	Belongs to the DEAD box helicase family
AMD11_RS18715	COG4206	TonB-dependent receptor
AMD11_RS18720	COG0720	synthase
AMD11_RS18730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AMD11_RS18740	COG1956	GAF domain-containing protein
AMD11_RS18750	COG2819	hydrolase of the alpha beta superfamily
AMD11_RS18765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMD11_RS18770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD11_RS18785	COG0339	signal peptide processing
AMD11_RS18835	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMD11_RS18840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD11_RS18845	COG4591	ABC-type transport system involved in lipoprotein release permease component
AMD11_RS18845	COG1136	(ABC) transporter
AMD11_RS18850	COG0577	efflux transmembrane transporter activity
AMD11_RS18850	COG1136	(ABC) transporter
AMD11_RS18855	COG0577	efflux transmembrane transporter activity
AMD11_RS18870	COG4191	Histidine kinase
AMD11_RS18875	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMD11_RS18890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AMD11_RS18895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AMD11_RS18900	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AMD11_RS18905	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMD11_RS18910	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMD11_RS18915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMD11_RS18925	COG0356	it plays a direct role in the translocation of protons across the membrane
AMD11_RS18945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMD11_RS18955	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMD11_RS19000	COG2011	ABC-type metal ion transport system permease component
AMD11_RS19005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMD11_RS19010	COG0697	spore germination
AMD11_RS19015	COG1666	GTP binding
AMD11_RS19025	COG2198	Histidine kinase
AMD11_RS19025	COG0784	Response regulator, receiver
AMD11_RS19025	COG5002	protein histidine kinase activity
AMD11_RS19050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMD11_RS19055	COG1187	pseudouridine synthase activity
AMD11_RS19060	COG2813	Specifically methylates the guanine in position
AMD11_RS19080	COG2205	protein histidine kinase activity
AMD11_RS19080	COG2202	Pas domain
AMD11_RS19100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMD11_RS19105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD11_RS19160	COG0842	Transport permease protein
AMD11_RS19165	COG1131	(ABC) transporter
AMD11_RS19170	COG0025	NhaP-type Na H and K H
AMD11_RS19175	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AMD11_RS19180	COG1573	uracil-dna glycosylase
AMD11_RS19190	COG3384	dioxygenase
AMD11_RS19200	COG0583	DNA-binding transcription factor activity
AMD11_RS19210	COG0667	Aldo Keto reductase
AMD11_RS19220	COG3590	peptidase
AMD11_RS19240	COG0531	amino acid
AMD11_RS19255	COG2972	Histidine kinase
AMD11_RS19270	COG3685	Protein conserved in bacteria
AMD11_RS19275	COG3546	catalase activity
AMD11_RS19320	COG1271	oxidase subunit
AMD11_RS19325	COG1294	oxidase, subunit
AMD11_RS19340	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS19345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMD11_RS19365	COG1132	(ABC) transporter
AMD11_RS19380	COG1063	alcohol dehydrogenase
AMD11_RS19455	COG0251	oxidation-reduction process
AMD11_RS19485	COG0840	transmembrane signaling receptor activity
AMD11_RS19505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMD11_RS19545	COG0024	Methionine aminopeptidase
AMD11_RS19565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMD11_RS19570	COG1490	D-aminoacyl-tRNA deacylase activity
AMD11_RS19575	COG1560	Kdo2-lipid A biosynthetic process
AMD11_RS19625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMD11_RS19625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AMD11_RS19630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMD11_RS19635	COG0242	peptide deformylase activity
AMD11_RS19640	COG1652	LysM domain
AMD11_RS19645	COG0758	DNA mediated transformation
AMD11_RS19650	COG2922	Belongs to the Smg family
AMD11_RS19665	COG1754	DNA topoisomerase type I activity
AMD11_RS19665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMD11_RS19670	COG0009	L-threonylcarbamoyladenylate synthase
AMD11_RS19685	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS19695	COG0616	signal peptide processing
AMD11_RS19700	COG0534	Mate efflux family protein
AMD11_RS19720	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AMD11_RS19725	COG0625	glutathione transferase activity
AMD11_RS19740	COG1252	NADH dehydrogenase
AMD11_RS19745	COG2860	membrane
AMD11_RS19750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMD11_RS19755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMD11_RS19760	COG2201	protein-glutamate methylesterase activity
AMD11_RS19765	COG2177	Part of the ABC transporter FtsEX involved in
AMD11_RS19770	COG2884	Cell division ATP-binding protein ftsE
AMD11_RS19775	COG0513	Belongs to the DEAD box helicase family
AMD11_RS19780	COG3118	belongs to the thioredoxin family
AMD11_RS19785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AMD11_RS19790	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AMD11_RS19795	COG0583	DNA-binding transcription factor activity
AMD11_RS19840	COG1518	maintenance of DNA repeat elements
AMD11_RS19845	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AMD11_RS19855	COG1652	LysM domain
AMD11_RS19860	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AMD11_RS19860	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AMD11_RS19865	COG1473	amidohydrolase
AMD11_RS19870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD11_RS19875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD11_RS19885	COG5383	Protein conserved in bacteria
AMD11_RS19925	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AMD11_RS19930	COG3023	N-Acetylmuramoyl-L-alanine amidase
AMD11_RS19940	COG4948	Mandelate Racemase Muconate Lactonizing
AMD11_RS19950	COG0531	amino acid
AMD11_RS19965	COG4682	membrane
AMD11_RS19970	COG2133	pyrroloquinoline quinone binding
AMD11_RS19980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AMD11_RS19985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMD11_RS19995	COG1610	YqeY-like protein
AMD11_RS20000	COG1295	ribonuclease BN
AMD11_RS20005	COG0358	DNA primase activity
AMD11_RS20020	COG0109	protoheme IX farnesyltransferase activity
AMD11_RS20050	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AMD11_RS20060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AMD11_RS20105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMD11_RS20110	COG0739	heme binding
AMD11_RS20115	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AMD11_RS20125	COG2223	nitrite transmembrane transporter activity
AMD11_RS20130	COG0708	Exodeoxyribonuclease III
AMD11_RS20135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMD11_RS20145	COG1192	Involved in chromosome partitioning
AMD11_RS20150	COG1475	DNA binding
AMD11_RS20165	COG0463	Glycosyl transferase, family 2
AMD11_RS20185	COG0756	dUTP diphosphatase activity
AMD11_RS20190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMD11_RS20195	COG2003	Belongs to the UPF0758 family
AMD11_RS20200	COG0018	arginyl-trna synthetase
AMD11_RS20215	COG4221	oxidoreductase activity
AMD11_RS20220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMD11_RS20220	COG2755	lipolytic protein G-D-S-L family
AMD11_RS20230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD11_RS20240	COG1166	arginine decarboxylase activity
AMD11_RS20245	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AMD11_RS20285	COG0606	chelatase, subunit chli
AMD11_RS20380	COG0606	chelatase, subunit chli
AMD11_RS20395	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AMD11_RS20430	COG1690	Belongs to the RtcB family
AMD11_RS20470	COG1090	epimerase
AMD11_RS20480	COG0642	Histidine kinase
AMD11_RS20500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD11_RS20525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMD11_RS20530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMD11_RS20545	COG0753	catalase activity
AMD11_RS20560	COG2197	response regulator
AMD11_RS20565	COG4585	Histidine kinase
AMD11_RS20570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD11_RS20575	COG1136	(ABC) transporter
AMD11_RS20600	COG0697	spore germination
AMD11_RS20615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD11_RS20620	COG0180	Tryptophanyl-tRNA synthetase
AMD11_RS20625	COG3237	CsbD-like
AMD11_RS20665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMD11_RS20680	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMD11_RS20725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMD11_RS20745	COG1199	ATP-dependent helicase activity
AMD11_RS20760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMD11_RS20820	COG0625	glutathione transferase activity
AMD11_RS20860	COG4555	ABC transporter
AMD11_RS20870	COG1476	TRANSCRIPTIONal
AMD11_RS20915	COG0543	2 iron, 2 sulfur cluster binding
AMD11_RS20915	COG0633	Ferredoxin
AMD11_RS20920	COG1131	(ABC) transporter
AMD11_RS20925	COG0842	Transport permease protein
AMD11_RS20935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMD11_RS20965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD11_RS20970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD11_RS20980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMD11_RS20980	COG0045	succinate-CoA ligase (ADP-forming) activity
AMD11_RS20980	COG1042	CoA-binding domain protein
AMD11_RS20985	COG2239	Acts as a magnesium transporter
AMD11_RS20990	COG3338	carbonate dehydratase activity
AMD11_RS21000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AMD11_RS21005	COG3387	PFAM Glycoside hydrolase 15-related
AMD11_RS21020	COG3100	YcgL domain-containing protein
AMD11_RS21025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMD11_RS21035	COG0463	Glycosyl transferase, family 2
AMD11_RS21050	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS21090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD11_RS21105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMD11_RS21130	COG4946	Tricorn protease homolog
AMD11_RS21130	COG1506	peptidase
AMD11_RS21130	COG0823	Involved in the tonB-independent uptake of proteins
AMD11_RS21145	COG0408	coproporphyrinogen oxidase activity
AMD11_RS21180	COG0515	serine threonine protein kinase
AMD11_RS21180	COG2815	serine threonine protein kinase
AMD11_RS21185	COG0631	protein serine/threonine phosphatase activity
AMD11_RS21345	COG0210	DNA helicase
AMD11_RS21360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD11_RS21365	COG0583	DNA-binding transcription factor activity
AMD11_RS21370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMD11_RS21380	COG2159	amidohydrolase
AMD11_RS21400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD11_RS21420	COG0357	Ribosomal RNA small subunit methyltransferase G
AMD11_RS21425	COG3540	Alkaline phosphatase
AMD11_RS21435	COG2091	lysine biosynthetic process via aminoadipic acid
AMD11_RS21455	COG0708	Exodeoxyribonuclease III
AMD11_RS21460	COG1940	carbohydrate kinase activity
AMD11_RS21460	COG1846	Transcriptional regulator
AMD11_RS21470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD11_RS21480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMD11_RS21485	COG3162	membrane
AMD11_RS21495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMD11_RS21525	COG3507	Belongs to the glycosyl hydrolase 43 family
AMD11_RS21545	COG1028	Short-chain dehydrogenase reductase Sdr
AMD11_RS21550	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMD11_RS21555	COG4948	Mandelate Racemase Muconate Lactonizing
AMD11_RS21565	COG3254	rhamnose metabolic process
AMD11_RS21570	COG0738	Major facilitator superfamily
AMD11_RS21575	COG1414	Transcriptional regulator
AMD11_RS21580	COG1971	Probably functions as a manganese efflux pump
AMD11_RS21585	COG2205	protein histidine kinase activity
AMD11_RS21600	COG3459	Glycosyltransferase 36 associated
AMD11_RS21605	COG2211	Major facilitator Superfamily
AMD11_RS21610	COG3265	gluconokinase activity
AMD11_RS21615	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD11_RS21635	COG2911	Protein conserved in bacteria
AMD11_RS21640	COG0729	surface antigen
AMD11_RS21680	COG0752	glycyl-tRNA synthetase alpha subunit
AMD11_RS21685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD11_RS21695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD11_RS21695	COG0519	Catalyzes the synthesis of GMP from XMP
AMD11_RS21705	COG0805	protein transport
AMD11_RS21710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMD11_RS21715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMD11_RS21725	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AMD11_RS21745	COG2974	May be involved in recombination
AMD11_RS21750	COG0037	tRNA processing
AMD11_RS21755	COG2115	Belongs to the xylose isomerase family
AMD11_RS21765	COG3661	Belongs to the glycosyl hydrolase 67 family
AMD11_RS21775	COG4948	Mandelate Racemase Muconate Lactonizing
AMD11_RS21785	COG1472	Belongs to the glycosyl hydrolase 3 family
AMD11_RS21790	COG0246	Mannitol dehydrogenase
AMD11_RS21865	COG3386	PFAM SMP-30 Gluconolaconase
AMD11_RS21875	COG3250	beta-galactosidase activity
AMD11_RS21880	COG1904	glucuronate isomerase
AMD11_RS21885	COG3693	PFAM glycoside hydrolase, family 10
AMD11_RS21900	COG3693	PFAM glycoside hydrolase, family 10
AMD11_RS21915	COG2211	Major facilitator Superfamily
AMD11_RS21960	COG2937	Belongs to the GPAT DAPAT family
AMD11_RS21995	COG0284	orotidine-5'-phosphate decarboxylase activity
AMD11_RS22000	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AMD11_RS22005	COG3132	Protein of unknown function, DUF480
AMD11_RS22020	COG0210	DNA helicase
AMD11_RS22025	COG1435	thymidine kinase activity
AMD11_RS22035	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AMD11_RS22045	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMD11_RS22080	COG3135	benzoate transporter
AMD11_RS22100	COG0676	glucose-6-phosphate 1-epimerase activity
AMD11_RS22110	COG3012	SEC-C Motif Domain Protein
AMD11_RS22115	COG0730	response to heat
AMD11_RS22135	COG0302	gtp cyclohydrolase
AMD11_RS22150	COG1566	PFAM secretion protein HlyD family protein
AMD11_RS22160	COG1289	transmembrane transporter activity
AMD11_RS22165	COG0477	Major facilitator Superfamily
AMD11_RS22175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD11_RS22195	COG4691	Plasmid stability protein
AMD11_RS22200	COG1487	ribonuclease activity
AMD11_RS22225	COG0564	pseudouridine synthase activity
AMD11_RS22260	COG0439	Biotin carboxylase
AMD11_RS22300	COG1074	ATP-dependent DNA helicase activity
AMD11_RS22305	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AMD11_RS22320	COG1127	ABC transporter
AMD11_RS22325	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMD11_RS22330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMD11_RS22345	COG2853	Lipoprotein
AMD11_RS22355	COG0386	Belongs to the glutathione peroxidase family
AMD11_RS22365	COG1322	Protein conserved in bacteria
AMD11_RS22370	COG0604	alcohol dehydrogenase
AMD11_RS22385	COG0625	glutathione transferase activity
AMD11_RS22395	COG0531	amino acid
AMD11_RS22400	COG3537	Alpha-1,2-mannosidase
AMD11_RS22410	COG3706	GGDEF domain
AMD11_RS22415	COG3835	regulator
AMD11_RS22420	COG1929	Belongs to the glycerate kinase type-1 family
AMD11_RS22425	COG2271	Major facilitator Superfamily
AMD11_RS22440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AMD11_RS22445	COG0861	Integral membrane protein TerC family
AMD11_RS22455	COG0584	glycerophosphoryl diester phosphodiesterase
AMD11_RS22470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AMD11_RS22475	COG0726	polysaccharide deacetylase
AMD11_RS22485	COG0706	membrane insertase activity
AMD11_RS22490	COG0594	ribonuclease P activity