locus-tag	class	description
BI316_RS00075	COG0210	DNA helicase
BI316_RS00090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI316_RS00095	COG0583	DNA-binding transcription factor activity
BI316_RS00100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI316_RS00115	COG2159	amidohydrolase
BI316_RS00135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI316_RS00155	COG0357	Ribosomal RNA small subunit methyltransferase G
BI316_RS00160	COG3540	Alkaline phosphatase
BI316_RS00170	COG2091	lysine biosynthetic process via aminoadipic acid
BI316_RS00185	COG0708	Exodeoxyribonuclease III
BI316_RS00190	COG1846	Transcriptional regulator
BI316_RS00190	COG1940	carbohydrate kinase activity
BI316_RS00200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI316_RS00210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI316_RS00215	COG3162	membrane
BI316_RS00225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI316_RS00255	COG3507	Belongs to the glycosyl hydrolase 43 family
BI316_RS00275	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS00280	COG0179	Fumarylacetoacetate (FAA) hydrolase
BI316_RS00290	COG4948	Mandelate Racemase Muconate Lactonizing
BI316_RS00300	COG3254	rhamnose metabolic process
BI316_RS00305	COG0738	Major facilitator superfamily
BI316_RS00310	COG1414	Transcriptional regulator
BI316_RS00315	COG1971	Probably functions as a manganese efflux pump
BI316_RS00320	COG2205	protein histidine kinase activity
BI316_RS00335	COG3459	Glycosyltransferase 36 associated
BI316_RS00340	COG2211	Major facilitator Superfamily
BI316_RS00345	COG3265	gluconokinase activity
BI316_RS00355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI316_RS00375	COG2911	Protein conserved in bacteria
BI316_RS00380	COG0729	surface antigen
BI316_RS00415	COG0752	glycyl-tRNA synthetase alpha subunit
BI316_RS00420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI316_RS00435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI316_RS00435	COG0519	Catalyzes the synthesis of GMP from XMP
BI316_RS00445	COG0805	protein transport
BI316_RS00450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI316_RS00455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI316_RS00465	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BI316_RS00490	COG2974	May be involved in recombination
BI316_RS00495	COG0037	tRNA processing
BI316_RS00505	COG2115	Belongs to the xylose isomerase family
BI316_RS00515	COG3661	Belongs to the glycosyl hydrolase 67 family
BI316_RS00525	COG4948	Mandelate Racemase Muconate Lactonizing
BI316_RS00535	COG1472	Belongs to the glycosyl hydrolase 3 family
BI316_RS00540	COG0246	Mannitol dehydrogenase
BI316_RS00615	COG3386	PFAM SMP-30 Gluconolaconase
BI316_RS00625	COG3250	beta-galactosidase activity
BI316_RS00630	COG1904	glucuronate isomerase
BI316_RS00645	COG3693	PFAM glycoside hydrolase, family 10
BI316_RS00660	COG2211	Major facilitator Superfamily
BI316_RS00725	COG2937	Belongs to the GPAT DAPAT family
BI316_RS00760	COG0284	orotidine-5'-phosphate decarboxylase activity
BI316_RS00765	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BI316_RS00775	COG3132	Protein of unknown function, DUF480
BI316_RS00790	COG0210	DNA helicase
BI316_RS00795	COG1435	thymidine kinase activity
BI316_RS00805	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BI316_RS00815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BI316_RS00850	COG3135	benzoate transporter
BI316_RS00870	COG0676	glucose-6-phosphate 1-epimerase activity
BI316_RS00880	COG3012	SEC-C Motif Domain Protein
BI316_RS00885	COG0730	response to heat
BI316_RS00905	COG0302	gtp cyclohydrolase
BI316_RS00920	COG1566	PFAM secretion protein HlyD family protein
BI316_RS00930	COG1289	transmembrane transporter activity
BI316_RS00935	COG0477	Major facilitator Superfamily
BI316_RS00945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI316_RS00965	COG4691	Plasmid stability protein
BI316_RS00970	COG1487	ribonuclease activity
BI316_RS00995	COG0564	pseudouridine synthase activity
BI316_RS01045	COG0439	Biotin carboxylase
BI316_RS01085	COG1074	ATP-dependent DNA helicase activity
BI316_RS01090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BI316_RS01105	COG1127	ABC transporter
BI316_RS01110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI316_RS01115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI316_RS01130	COG2853	Lipoprotein
BI316_RS01140	COG0386	Belongs to the glutathione peroxidase family
BI316_RS01150	COG1322	Protein conserved in bacteria
BI316_RS01155	COG0604	alcohol dehydrogenase
BI316_RS01175	COG0625	glutathione transferase activity
BI316_RS01185	COG0531	amino acid
BI316_RS01190	COG3537	Alpha-1,2-mannosidase
BI316_RS01205	COG3706	GGDEF domain
BI316_RS01210	COG3835	regulator
BI316_RS01215	COG1929	Belongs to the glycerate kinase type-1 family
BI316_RS01220	COG2271	Major facilitator Superfamily
BI316_RS01235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BI316_RS01245	COG0861	Integral membrane protein TerC family
BI316_RS01260	COG0584	glycerophosphoryl diester phosphodiesterase
BI316_RS01275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BI316_RS01280	COG0726	polysaccharide deacetylase
BI316_RS01285	COG0706	membrane insertase activity
BI316_RS01290	COG0594	ribonuclease P activity
BI316_RS01305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BI316_RS01315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BI316_RS01320	COG0187	DNA topoisomerase II activity
BI316_RS01330	COG0501	Belongs to the peptidase M48B family
BI316_RS01360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BI316_RS01370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI316_RS01415	COG0793	Belongs to the peptidase S41A family
BI316_RS01420	COG4942	peptidase
BI316_RS01430	COG2234	aminopeptidase activity
BI316_RS01440	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI316_RS01450	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI316_RS01455	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI316_RS01465	COG1064	alcohol dehydrogenase
BI316_RS01475	COG0493	'glutamate synthase
BI316_RS01480	COG0067	glutamate synthase
BI316_RS01480	COG0069	glutamate synthase activity
BI316_RS01480	COG0070	glutamate synthase
BI316_RS01530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BI316_RS01545	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BI316_RS01550	COG0438	transferase activity, transferring glycosyl groups
BI316_RS01550	COG0297	glycogen (starch) synthase activity
BI316_RS01570	COG0367	asparagine synthase
BI316_RS01600	COG1132	(ABC) transporter
BI316_RS01630	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BI316_RS01725	COG1205	dead DEAH box helicase
BI316_RS01725	COG1111	helicase
BI316_RS01730	COG1272	protein, Hemolysin III
BI316_RS01750	COG0300	oxidoreductase activity
BI316_RS01755	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS01780	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI316_RS01850	COG3237	CsbD-like
BI316_RS01900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI316_RS01910	COG0477	Major facilitator Superfamily
BI316_RS01950	COG0714	Associated with various cellular activities
BI316_RS01980	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BI316_RS01990	COG4772	TonB-dependent receptor
BI316_RS02000	COG0662	Cupin 2, conserved barrel domain protein
BI316_RS02005	COG1012	belongs to the aldehyde dehydrogenase family
BI316_RS02030	COG1304	FMN binding
BI316_RS02045	COG4585	Histidine kinase
BI316_RS02050	COG2197	response regulator
BI316_RS02070	COG3710	Transcriptional regulator
BI316_RS02075	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BI316_RS02160	COG0366	Alpha amylase catalytic
BI316_RS02165	COG0366	Alpha amylase catalytic
BI316_RS02170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI316_RS02195	COG0657	acetylesterase activity
BI316_RS02195	COG2755	lipolytic protein G-D-S-L family
BI316_RS02205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI316_RS02220	COG3507	Belongs to the glycosyl hydrolase 43 family
BI316_RS02225	COG1609	Transcriptional regulator
BI316_RS02235	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BI316_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS02250	COG2755	lipolytic protein G-D-S-L family
BI316_RS02265	COG3186	Phenylalanine-4-hydroxylase
BI316_RS02270	COG1522	sequence-specific DNA binding
BI316_RS02280	COG1752	Esterase of the alpha-beta hydrolase superfamily
BI316_RS02290	COG1119	ATPase activity
BI316_RS02305	COG1125	glycine betaine transport
BI316_RS02320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI316_RS02340	COG1396	sequence-specific DNA binding
BI316_RS02365	COG0489	protein tyrosine kinase activity
BI316_RS02370	COG2062	phosphohistidine phosphatase, SixA
BI316_RS02380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI316_RS02430	COG1968	undecaprenyl-diphosphatase activity
BI316_RS02440	COG0174	glutamine synthetase
BI316_RS02445	COG0347	Belongs to the P(II) protein family
BI316_RS02450	COG0004	ammonium transporteR
BI316_RS02455	COG3852	Histidine kinase
BI316_RS02460	COG2204	response regulator
BI316_RS02465	COG2032	superoxide dismutase activity
BI316_RS02470	COG2032	superoxide dismutase activity
BI316_RS02480	COG0346	lactoylglutathione lyase activity
BI316_RS02490	COG0183	Belongs to the thiolase family
BI316_RS02525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI316_RS02530	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BI316_RS02535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BI316_RS02550	COG0028	Belongs to the TPP enzyme family
BI316_RS02555	COG2205	protein histidine kinase activity
BI316_RS02580	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BI316_RS02595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI316_RS02605	COG0596	Alpha beta hydrolase
BI316_RS02610	COG0727	PFAM Uncharacterised protein family (UPF0153)
BI316_RS02615	COG0318	PFAM AMP-dependent synthetase and ligase
BI316_RS02620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI316_RS02635	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI316_RS02650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI316_RS02660	COG0564	pseudouridine synthase activity
BI316_RS02685	COG0339	signal peptide processing
BI316_RS02715	COG0475	glutathione-regulated potassium exporter activity
BI316_RS02720	COG0583	DNA-binding transcription factor activity
BI316_RS02725	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BI316_RS02730	COG2224	Isocitrate lyase
BI316_RS02760	COG4770	biotin carboxylase activity
BI316_RS02765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI316_RS02770	COG1960	acyl-CoA dehydrogenase activity
BI316_RS02830	COG0523	cobalamin synthesis protein
BI316_RS02840	COG0697	spore germination
BI316_RS02850	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BI316_RS02855	COG1846	Transcriptional regulator
BI316_RS02860	COG1764	response to oxidative stress
BI316_RS02890	COG2130	NADP-dependent
BI316_RS02905	COG1187	pseudouridine synthase activity
BI316_RS02920	COG1643	Atp-dependent helicase
BI316_RS02930	COG4807	Protein conserved in bacteria
BI316_RS02935	COG2351	hydroxyisourate hydrolase activity
BI316_RS02940	COG2072	flavoprotein involved in K transport
BI316_RS02960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BI316_RS03005	COG2252	PERMEase
BI316_RS03030	COG0084	hydrolase, TatD family'
BI316_RS03045	COG0583	DNA-binding transcription factor activity
BI316_RS03050	COG2814	Major facilitator Superfamily
BI316_RS03065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BI316_RS03070	COG1902	pentaerythritol trinitrate reductase activity
BI316_RS03090	COG0745	RESPONSE REGULATOR receiver
BI316_RS03095	COG2205	protein histidine kinase activity
BI316_RS03100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI316_RS03120	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI316_RS03125	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI316_RS03130	COG0583	DNA-binding transcription factor activity
BI316_RS03165	COG0702	epimerase
BI316_RS03170	COG1733	regulation of RNA biosynthetic process
BI316_RS03210	COG0129	dihydroxy-acid dehydratase activity
BI316_RS03225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BI316_RS03280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BI316_RS03285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BI316_RS03310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BI316_RS03315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BI316_RS03325	COG3485	protocatechuate 3,4-dioxygenase
BI316_RS03330	COG3485	protocatechuate 3,4-dioxygenase
BI316_RS03340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI316_RS03345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BI316_RS03355	COG1414	Transcriptional regulator
BI316_RS03365	COG0657	acetylesterase activity
BI316_RS03375	COG0445	tRNA wobble uridine modification
BI316_RS03385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BI316_RS03415	COG2267	carboxylic ester hydrolase activity
BI316_RS03425	COG0156	8-amino-7-oxononanoate synthase activity
BI316_RS03430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BI316_RS03435	COG1040	competence protein
BI316_RS03440	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BI316_RS03525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI316_RS03600	COG1511	domain protein
BI316_RS03600	COG3264	Mechanosensitive ion channel
BI316_RS03605	COG1368	sulfuric ester hydrolase activity
BI316_RS03615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI316_RS03620	COG2354	Protein conserved in bacteria
BI316_RS03630	COG0297	glycogen (starch) synthase activity
BI316_RS03635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI316_RS03640	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI316_RS03665	COG0702	epimerase
BI316_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS03705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI316_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS03720	COG0513	Belongs to the DEAD box helicase family
BI316_RS03740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BI316_RS03750	COG3483	tryptophan 2,3-dioxygenase activity
BI316_RS03755	COG3104	oligopeptide transport
BI316_RS03780	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BI316_RS03800	COG1320	monovalent cation:proton antiporter activity
BI316_RS03805	COG2212	antiporter activity
BI316_RS03815	COG0651	ATP synthesis coupled electron transport
BI316_RS03820	COG1006	Multisubunit Na H antiporter MnhC subunit
BI316_RS03825	COG2111	Na H antiporter
BI316_RS03825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI316_RS03850	COG3179	chitinase
BI316_RS03870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BI316_RS03875	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BI316_RS03890	COG0456	acetyltransferase
BI316_RS03895	COG1597	lipid kinase activity
BI316_RS03920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BI316_RS03925	COG0134	indole-3-glycerol-phosphate synthase activity
BI316_RS03935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI316_RS03940	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BI316_RS03950	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BI316_RS03960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BI316_RS03975	COG1051	belongs to the nudix hydrolase family
BI316_RS04015	COG0316	Belongs to the HesB IscA family
BI316_RS04045	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI316_RS04065	COG2814	Major facilitator Superfamily
BI316_RS04070	COG0583	DNA-binding transcription factor activity
BI316_RS04075	COG2814	Major facilitator Superfamily
BI316_RS04080	COG1289	transmembrane transporter activity
BI316_RS04090	COG0151	Belongs to the GarS family
BI316_RS04100	COG0138	bifunctional purine biosynthesis protein purh
BI316_RS04105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BI316_RS04110	COG2267	carboxylic ester hydrolase activity
BI316_RS04115	COG0671	phosphoesterase, PA-phosphatase related
BI316_RS04115	COG2453	phosphatase
BI316_RS04140	COG4589	Belongs to the CDS family
BI316_RS04145	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BI316_RS04165	COG2264	protein methyltransferase activity
BI316_RS04185	COG0439	Biotin carboxylase
BI316_RS04195	COG0511	ligase activity, forming carbon-carbon bonds
BI316_RS04200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BI316_RS04210	COG1324	tolerance protein
BI316_RS04240	COG0300	oxidoreductase activity
BI316_RS04245	COG2356	endonuclease I
BI316_RS04260	COG0459	protein refolding
BI316_RS04275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BI316_RS04290	COG3386	PFAM SMP-30 Gluconolaconase
BI316_RS04300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BI316_RS04305	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI316_RS04325	COG0778	Nitroreductase
BI316_RS04330	COG2353	YceI-like domain
BI316_RS04360	COG3052	prosthetic group binding
BI316_RS04385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BI316_RS04395	COG1802	Transcriptional regulator
BI316_RS04455	COG4221	oxidoreductase activity
BI316_RS04470	COG4221	oxidoreductase activity
BI316_RS04480	COG0435	Glutathione S-transferase
BI316_RS04505	COG2409	Drug exporters of the RND superfamily
BI316_RS04515	COG1506	peptidase
BI316_RS04515	COG0823	Involved in the tonB-independent uptake of proteins
BI316_RS04555	COG0697	spore germination
BI316_RS04570	COG1113	amino acid transport
BI316_RS04590	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
BI316_RS04640	COG0840	transmembrane signaling receptor activity
BI316_RS04645	COG5297	Belongs to the glycosyl hydrolase family 6
BI316_RS04645	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI316_RS04650	COG0659	secondary active sulfate transmembrane transporter activity
BI316_RS04680	COG2943	transferase activity, transferring hexosyl groups
BI316_RS04690	COG3275	phosphorelay sensor kinase activity
BI316_RS04700	COG0181	hydroxymethylbilane synthase activity
BI316_RS04730	COG1505	serine-type exopeptidase activity
BI316_RS04735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI316_RS04740	COG0436	Aminotransferase
BI316_RS04755	COG2832	Protein of unknown function (DUF454)
BI316_RS04765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BI316_RS04775	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BI316_RS04780	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BI316_RS04785	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BI316_RS04810	COG2226	methyltransferase
BI316_RS04815	COG5001	Diguanylate cyclase
BI316_RS04815	COG3300	MHYT domain
BI316_RS04820	COG0308	aminopeptidase N
BI316_RS04870	COG3284	Transcriptional regulator
BI316_RS04875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI316_RS04880	COG1077	Cell shape determining protein MreB Mrl
BI316_RS04885	COG1792	Involved in formation and maintenance of cell shape
BI316_RS04900	COG0772	Belongs to the SEDS family
BI316_RS04910	COG2951	lytic endotransglycosylase activity
BI316_RS04915	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BI316_RS04925	COG1686	Belongs to the peptidase S11 family
BI316_RS04935	COG2921	Belongs to the UPF0250 family
BI316_RS04940	COG0321	lipoyl(octanoyl) transferase activity
BI316_RS04945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BI316_RS04960	COG0583	DNA-binding transcription factor activity
BI316_RS04970	COG1051	belongs to the nudix hydrolase family
BI316_RS04970	COG1056	cytidyltransferase-related domain
BI316_RS05005	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BI316_RS05010	COG0673	inositol 2-dehydrogenase activity
BI316_RS05015	COG2823	Periplasmic or secreted lipoprotein
BI316_RS05020	COG4251	negative regulation of phosphorylation
BI316_RS05025	COG0784	Response regulator, receiver
BI316_RS05030	COG4191	Histidine kinase
BI316_RS05035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BI316_RS05095	COG1459	type II secretion system
BI316_RS05160	COG2188	Transcriptional regulator
BI316_RS05170	COG1609	Transcriptional regulator
BI316_RS05175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI316_RS05180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BI316_RS05190	COG0617	tRNA 3'-terminal CCA addition
BI316_RS05195	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BI316_RS05200	COG1012	belongs to the aldehyde dehydrogenase family
BI316_RS05205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI316_RS05220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI316_RS05235	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BI316_RS05240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BI316_RS05260	COG2205	protein histidine kinase activity
BI316_RS05290	COG3791	Glutathione-dependent formaldehyde-activating
BI316_RS05305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI316_RS05315	COG0697	spore germination
BI316_RS05325	COG0488	(ABC) transporter
BI316_RS05335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BI316_RS05340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BI316_RS05350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI316_RS05350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI316_RS05370	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BI316_RS05375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI316_RS05380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BI316_RS05405	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BI316_RS05410	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BI316_RS05415	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BI316_RS05420	COG2205	protein histidine kinase activity
BI316_RS05425	COG0745	RESPONSE REGULATOR receiver
BI316_RS05465	COG0277	FAD linked oxidase domain protein
BI316_RS05470	COG1988	membrane-bound metal-dependent
BI316_RS05475	COG0792	nuclease activity
BI316_RS05510	COG0275	rRNA processing
BI316_RS05515	COG3116	cell division
BI316_RS05525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BI316_RS05530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BI316_RS05535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI316_RS05545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BI316_RS05550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI316_RS05555	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI316_RS05560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BI316_RS05575	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BI316_RS05585	COG0739	heme binding
BI316_RS05590	COG0653	protein targeting
BI316_RS05595	COG0494	nUDIX hydrolase
BI316_RS05605	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI316_RS05620	COG3321	synthase
BI316_RS05620	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS05620	COG0604	alcohol dehydrogenase
BI316_RS05650	COG0366	Alpha amylase catalytic
BI316_RS05685	COG2226	methyltransferase
BI316_RS05690	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BI316_RS05705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BI316_RS05750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BI316_RS05760	COG4106	trans-aconitate 2-methyltransferase activity
BI316_RS05765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI316_RS05775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI316_RS05780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI316_RS05790	COG0667	Aldo Keto reductase
BI316_RS05800	COG4771	TonB-dependent receptor
BI316_RS05820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI316_RS05825	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BI316_RS05835	COG2175	clavaminate synthase activity
BI316_RS05845	COG4181	ATPase activity
BI316_RS05860	COG0642	Histidine kinase
BI316_RS05875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BI316_RS05895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BI316_RS05900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BI316_RS05915	COG3829	transcription factor binding
BI316_RS05925	COG1116	anion transmembrane transporter activity
BI316_RS05930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI316_RS05940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI316_RS05945	COG0431	NADPH-dependent FMN reductase
BI316_RS05970	COG0747	negative chemotaxis
BI316_RS05980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI316_RS05990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BI316_RS05995	COG2967	ApaG domain
BI316_RS06000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BI316_RS06005	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BI316_RS06010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI316_RS06015	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BI316_RS06030	COG0123	including yeast histone deacetylase and acetoin utilization protein
BI316_RS06035	COG2096	Adenosyltransferase
BI316_RS06050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI316_RS06055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI316_RS06085	COG3384	dioxygenase
BI316_RS06090	COG0583	DNA-binding transcription factor activity
BI316_RS06105	COG1024	Enoyl-CoA hydratase
BI316_RS06125	COG3386	PFAM SMP-30 Gluconolaconase
BI316_RS06140	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BI316_RS06165	COG0697	spore germination
BI316_RS06175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI316_RS06195	COG2205	protein histidine kinase activity
BI316_RS06195	COG5002	protein histidine kinase activity
BI316_RS06195	COG0784	Response regulator, receiver
BI316_RS06200	COG2197	response regulator
BI316_RS06210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI316_RS06220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BI316_RS06225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI316_RS06235	COG0583	DNA-binding transcription factor activity
BI316_RS06240	COG3634	alkyl hydroperoxide reductase activity
BI316_RS06250	COG2890	protein-(glutamine-N5) methyltransferase activity
BI316_RS06270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI316_RS06270	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI316_RS06300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BI316_RS06330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BI316_RS06345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI316_RS06350	COG1404	Belongs to the peptidase S8 family
BI316_RS06360	COG1404	Belongs to the peptidase S8 family
BI316_RS06365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BI316_RS06390	COG1295	ribonuclease BN
BI316_RS06395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI316_RS06415	COG0521	Mo-molybdopterin cofactor biosynthetic process
BI316_RS06425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BI316_RS06440	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BI316_RS06445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BI316_RS06455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BI316_RS06460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BI316_RS06465	COG0193	aminoacyl-tRNA hydrolase activity
BI316_RS06470	COG0012	GTP binding
BI316_RS06490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI316_RS06505	COG0250	Participates in transcription elongation, termination and antitermination
BI316_RS06510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BI316_RS06515	COG0081	regulation of translation
BI316_RS06520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BI316_RS06525	COG0222	ribosome binding
BI316_RS06530	COG0085	RNA polymerase activity
BI316_RS06535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BI316_RS06540	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BI316_RS06545	COG0049	tRNA binding
BI316_RS06550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BI316_RS06555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI316_RS06560	COG0051	transcription antitermination factor activity, RNA binding
BI316_RS06565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BI316_RS06570	COG0088	Forms part of the polypeptide exit tunnel
BI316_RS06575	COG0089	rRNA binding
BI316_RS06580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BI316_RS06585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BI316_RS06595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BI316_RS06600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BI316_RS06605	COG0255	Belongs to the universal ribosomal protein uL29 family
BI316_RS06610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BI316_RS06620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BI316_RS06625	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BI316_RS06635	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BI316_RS06640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BI316_RS06645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BI316_RS06655	COG1841	ribosomal large subunit assembly
BI316_RS06660	COG0200	Binds to the 23S rRNA
BI316_RS06665	COG0201	protein transport
BI316_RS06690	COG0203	ribosomal protein L17
BI316_RS06695	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BI316_RS06715	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BI316_RS06725	COG0154	amidase activity
BI316_RS06735	COG1217	gtp-binding protein TYPA
BI316_RS06740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BI316_RS06745	COG0039	L-malate dehydrogenase activity
BI316_RS06750	COG0625	glutathione transferase activity
BI316_RS06765	COG1902	pentaerythritol trinitrate reductase activity
BI316_RS06765	COG0446	pyridine nucleotide-disulphide oxidoreductase
BI316_RS06770	COG0604	alcohol dehydrogenase
BI316_RS06800	COG0156	8-amino-7-oxononanoate synthase activity
BI316_RS06805	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BI316_RS06810	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BI316_RS06815	COG4208	sulfate ABC transporter
BI316_RS06820	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BI316_RS06830	COG1063	alcohol dehydrogenase
BI316_RS06860	COG0406	alpha-ribazole phosphatase activity
BI316_RS06865	COG0285	dihydrofolate synthase activity
BI316_RS06885	COG2833	Protein of unknown function (DUF455)
BI316_RS06895	COG3291	Pkd domain containing protein
BI316_RS06905	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI316_RS06910	COG0671	phosphoesterase, PA-phosphatase related
BI316_RS06915	COG0438	transferase activity, transferring glycosyl groups
BI316_RS06925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BI316_RS06940	COG4783	chaperone-mediated protein folding
BI316_RS06955	COG0473	3-isopropylmalate dehydrogenase activity
BI316_RS07115	COG0544	peptidyl-prolyl cis-trans isomerase activity
BI316_RS07125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BI316_RS07150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI316_RS07160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI316_RS07170	COG0328	RNA-DNA hybrid ribonuclease activity
BI316_RS07175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI316_RS07180	COG0631	protein serine/threonine phosphatase activity
BI316_RS07195	COG0859	PFAM glycosyl transferase family 9
BI316_RS07200	COG3642	lipopolysaccharide core region biosynthetic process
BI316_RS07205	COG1234	tRNA 3'-trailer cleavage
BI316_RS07210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BI316_RS07220	COG0315	cyclic pyranopterin monophosphate synthase activity
BI316_RS07225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BI316_RS07230	COG0314	molybdopterin synthase activity
BI316_RS07285	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BI316_RS07290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BI316_RS07295	COG0537	adenosine 5'-monophosphoramidase activity
BI316_RS07315	COG0714	Associated with various cellular activities
BI316_RS07340	COG0424	maF-like protein
BI316_RS07345	COG1399	metal-binding, possibly nucleic acid-binding protein
BI316_RS07350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BI316_RS07355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI316_RS07370	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS07385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BI316_RS07390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BI316_RS07415	COG3829	transcription factor binding
BI316_RS07435	COG3609	addiction module antidote protein, CC2985 family
BI316_RS07465	COG2373	Large extracellular alpha-helical protein
BI316_RS07485	COG4953	penicillin-binding protein 1C
BI316_RS07495	COG0678	peroxiredoxin activity
BI316_RS07515	COG0330	HflC and HflK could
BI316_RS07520	COG0330	HflC and HflK could
BI316_RS07535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BI316_RS07540	COG0308	aminopeptidase N
BI316_RS07545	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS07550	COG1309	transcriptional regulator
BI316_RS07595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BI316_RS07630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI316_RS07640	COG3387	PFAM Glycoside hydrolase 15-related
BI316_RS07645	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS07655	COG3537	Alpha-1,2-mannosidase
BI316_RS07675	COG0492	ferredoxin-NADP+ reductase activity
BI316_RS07700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI316_RS07705	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI316_RS07710	COG2080	2 iron, 2 sulfur cluster binding
BI316_RS07745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI316_RS07760	COG0587	DNA-directed DNA polymerase activity
BI316_RS07780	COG1297	OPT oligopeptide transporter protein
BI316_RS07795	COG1506	peptidase
BI316_RS07795	COG0823	Involved in the tonB-independent uptake of proteins
BI316_RS07815	COG1917	Cupin 2, conserved barrel domain protein
BI316_RS07815	COG2207	Transcriptional regulator
BI316_RS07830	COG0753	catalase activity
BI316_RS07835	COG0656	L-ascorbic acid biosynthetic process
BI316_RS07845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI316_RS07845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI316_RS07850	COG2814	Major facilitator Superfamily
BI316_RS07865	COG2194	sulfuric ester hydrolase activity
BI316_RS07880	COG0745	RESPONSE REGULATOR receiver
BI316_RS07885	COG0642	Histidine kinase
BI316_RS07895	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BI316_RS07900	COG2894	cell division
BI316_RS07905	COG0850	regulation of cytokinetic process
BI316_RS07920	COG4585	Histidine kinase
BI316_RS07925	COG2197	response regulator
BI316_RS07940	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BI316_RS07970	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BI316_RS07980	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BI316_RS08000	COG1946	Acyl-CoA thioesterase
BI316_RS08015	COG0824	Thioesterase
BI316_RS08020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BI316_RS08025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BI316_RS08030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BI316_RS08035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BI316_RS08040	COG0268	Binds directly to 16S ribosomal RNA
BI316_RS08050	COG0196	riboflavin kinase activity
BI316_RS08055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BI316_RS08060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BI316_RS08065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BI316_RS08080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BI316_RS08085	COG1845	cytochrome c oxidase, subunit III
BI316_RS08090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BI316_RS08105	COG3152	Membrane
BI316_RS08115	COG2207	Transcriptional regulator
BI316_RS08120	COG0326	Molecular chaperone. Has ATPase activity
BI316_RS08135	COG1366	Belongs to the anti-sigma-factor antagonist family
BI316_RS08140	COG1366	Belongs to the anti-sigma-factor antagonist family
BI316_RS08145	COG2172	sigma factor antagonist activity
BI316_RS08170	COG4771	TonB-dependent receptor
BI316_RS08180	COG5507	3-demethylubiquinone-9 3-methyltransferase
BI316_RS08185	COG2205	protein histidine kinase activity
BI316_RS08195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI316_RS08200	COG4999	Histidine kinase
BI316_RS08200	COG3850	Histidine kinase
BI316_RS08200	COG2205	protein histidine kinase activity
BI316_RS08200	COG3437	response regulator, receiver
BI316_RS08205	COG0784	Response regulator, receiver
BI316_RS08205	COG4191	Histidine kinase
BI316_RS08230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI316_RS08235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BI316_RS08245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI316_RS08250	COG0228	four-way junction DNA binding
BI316_RS08255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BI316_RS08260	COG0336	Belongs to the RNA methyltransferase TrmD family
BI316_RS08265	COG0335	large ribosomal subunit rRNA binding
BI316_RS08290	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BI316_RS08300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BI316_RS08320	COG3209	COG3209 Rhs family protein
BI316_RS08345	COG3250	beta-galactosidase activity
BI316_RS08350	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BI316_RS08370	COG1960	acyl-CoA dehydrogenase activity
BI316_RS08375	COG1024	Enoyl-CoA hydratase
BI316_RS08395	COG1024	Enoyl-CoA hydratase
BI316_RS08395	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI316_RS08410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI316_RS08415	COG0481	GTPase activity
BI316_RS08430	COG0571	ribonuclease III activity
BI316_RS08435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BI316_RS08440	COG1381	Involved in DNA repair and RecF pathway recombination
BI316_RS08450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI316_RS08455	COG2954	triphosphatase activity
BI316_RS08460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BI316_RS08465	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BI316_RS08470	COG3046	protein related to deoxyribodipyrimidine photolyase
BI316_RS08475	COG1472	Belongs to the glycosyl hydrolase 3 family
BI316_RS08480	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BI316_RS08485	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BI316_RS08490	COG1278	Cold shock
BI316_RS08495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI316_RS08505	COG1201	RNA secondary structure unwinding
BI316_RS08510	COG1793	dna ligase
BI316_RS08520	COG1793	dna ligase
BI316_RS08520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BI316_RS08555	COG0183	Belongs to the thiolase family
BI316_RS08580	COG1451	nucleotide metabolic process
BI316_RS08585	COG5487	UPF0391 membrane protein
BI316_RS08595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BI316_RS08610	COG1077	Cell shape determining protein MreB Mrl
BI316_RS08615	COG1047	Peptidyl-prolyl cis-trans
BI316_RS08625	COG2824	Alkylphosphonate utilization operon protein PhnA
BI316_RS08635	COG1902	pentaerythritol trinitrate reductase activity
BI316_RS08640	COG2814	Major facilitator Superfamily
BI316_RS08675	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BI316_RS08675	COG0392	lysyltransferase activity
BI316_RS08685	COG0251	oxidation-reduction process
BI316_RS08690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI316_RS08705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI316_RS08730	COG1595	DNA-templated transcription, initiation
BI316_RS08750	COG2878	Part of a membrane complex involved in electron transport
BI316_RS08760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI316_RS08760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI316_RS08775	COG1131	(ABC) transporter
BI316_RS08780	COG0346	lactoylglutathione lyase activity
BI316_RS08785	COG0833	amino acid
BI316_RS08790	COG2040	homocysteine
BI316_RS08800	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI316_RS08820	COG1695	Transcriptional regulator
BI316_RS08840	COG1981	membrane
BI316_RS08855	COG0825	malonyl-CoA metabolic process
BI316_RS08865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BI316_RS08870	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI316_RS08875	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI316_RS08880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI316_RS08885	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI316_RS08900	COG0750	zinc metalloprotease
BI316_RS08905	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BI316_RS08910	COG0575	Belongs to the CDS family
BI316_RS08915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BI316_RS08920	COG0233	cytoplasmic translational termination
BI316_RS08925	COG0528	UMP kinase activity
BI316_RS08935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BI316_RS08940	COG0052	Belongs to the universal ribosomal protein uS2 family
BI316_RS08980	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BI316_RS08990	COG1393	Belongs to the ArsC family
BI316_RS08995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI316_RS09000	COG0367	asparagine synthase
BI316_RS09010	COG4774	siderophore transport
BI316_RS09030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI316_RS09060	COG1566	PFAM secretion protein HlyD family protein
BI316_RS09065	COG2814	Major facilitator Superfamily
BI316_RS09115	COG0339	signal peptide processing
BI316_RS09125	COG0386	Belongs to the glutathione peroxidase family
BI316_RS09180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BI316_RS09185	COG0084	hydrolase, TatD family'
BI316_RS09200	COG1960	acyl-CoA dehydrogenase activity
BI316_RS09220	COG0367	asparagine synthase
BI316_RS09230	COG0305	Participates in initiation and elongation during chromosome replication
BI316_RS09235	COG0415	Belongs to the DNA photolyase family
BI316_RS09260	COG0583	DNA-binding transcription factor activity
BI316_RS09305	COG3706	GGDEF domain
BI316_RS09430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BI316_RS09445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI316_RS09455	COG0497	DNA recombination
BI316_RS09460	COG1420	regulation of RNA biosynthetic process
BI316_RS09465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BI316_RS09470	COG0443	Heat shock 70 kDa protein
BI316_RS09475	COG0484	heat shock protein binding
BI316_RS09485	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BI316_RS09515	COG0583	DNA-binding transcription factor activity
BI316_RS09520	COG1132	(ABC) transporter
BI316_RS09555	COG2850	peptidyl-arginine hydroxylation
BI316_RS09575	COG1253	flavin adenine dinucleotide binding
BI316_RS09605	COG1131	(ABC) transporter
BI316_RS09610	COG1725	Transcriptional regulator
BI316_RS09620	COG0386	Belongs to the glutathione peroxidase family
BI316_RS09635	COG2900	Belongs to the SlyX family
BI316_RS09660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI316_RS09670	COG0646	methionine synthase
BI316_RS09670	COG1410	methionine synthase
BI316_RS09675	COG1410	methionine synthase
BI316_RS09675	COG0646	methionine synthase
BI316_RS09680	COG2226	methyltransferase
BI316_RS09685	COG1960	acyl-CoA dehydrogenase activity
BI316_RS09690	COG1960	acyl-CoA dehydrogenase activity
BI316_RS09695	COG1960	acyl-CoA dehydrogenase activity
BI316_RS09700	COG1960	acyl-CoA dehydrogenase activity
BI316_RS09720	COG0557	exoribonuclease II activity
BI316_RS09730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI316_RS09740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI316_RS09750	COG0704	Plays a role in the regulation of phosphate uptake
BI316_RS09755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BI316_RS09760	COG0581	inorganic phosphate transmembrane transporter activity
BI316_RS09765	COG0573	inorganic phosphate transmembrane transporter activity
BI316_RS09770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BI316_RS09795	COG0659	secondary active sulfate transmembrane transporter activity
BI316_RS09800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BI316_RS09810	COG1024	Enoyl-CoA hydratase
BI316_RS09820	COG0494	nUDIX hydrolase
BI316_RS09855	COG0488	(ABC) transporter
BI316_RS09870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BI316_RS09895	COG2925	Exonuclease
BI316_RS09905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI316_RS09910	COG3844	kynureninase activity
BI316_RS09920	COG0662	Cupin 2, conserved barrel domain protein
BI316_RS09925	COG0288	reversible hydration of carbon dioxide
BI316_RS09990	COG2808	Putative FMN-binding domain
BI316_RS10010	COG0017	Asparaginyl-tRNA synthetase
BI316_RS10020	COG0316	Belongs to the HesB IscA family
BI316_RS10025	COG0360	Binds together with S18 to 16S ribosomal RNA
BI316_RS10030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BI316_RS10035	COG0359	binds to the 23S rRNA
BI316_RS10045	COG3115	cell septum assembly
BI316_RS10055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI316_RS10060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BI316_RS10065	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BI316_RS10080	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BI316_RS10090	COG4993	Dehydrogenase
BI316_RS10105	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BI316_RS10115	COG2986	histidine ammonia-lyase
BI316_RS10120	COG1228	amidohydrolase
BI316_RS10165	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BI316_RS10170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BI316_RS10175	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BI316_RS10180	COG0077	Prephenate dehydratase
BI316_RS10180	COG1605	Chorismate mutase
BI316_RS10185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BI316_RS10200	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BI316_RS10205	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI316_RS10210	COG0583	DNA-binding transcription factor activity
BI316_RS10270	COG0840	transmembrane signaling receptor activity
BI316_RS10305	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BI316_RS10310	COG4191	Histidine kinase
BI316_RS10310	COG0784	Response regulator, receiver
BI316_RS10325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI316_RS10335	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BI316_RS10345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI316_RS10360	COG1595	DNA-templated transcription, initiation
BI316_RS10415	COG2244	polysaccharide biosynthetic process
BI316_RS10450	COG2264	protein methyltransferase activity
BI316_RS10460	COG0438	transferase activity, transferring glycosyl groups
BI316_RS10475	COG1136	(ABC) transporter
BI316_RS10485	COG0477	Major facilitator Superfamily
BI316_RS10490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI316_RS10505	COG1253	flavin adenine dinucleotide binding
BI316_RS10520	COG0306	phosphate transporter
BI316_RS10545	COG0504	CTP synthase activity
BI316_RS10550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BI316_RS10560	COG0148	phosphopyruvate hydratase activity
BI316_RS10565	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BI316_RS10570	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BI316_RS10575	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BI316_RS10580	COG0585	pseudouridine synthase activity
BI316_RS10585	COG2840	Smr protein MutS2
BI316_RS10590	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BI316_RS10595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI316_RS10600	COG1238	metal cluster binding
BI316_RS10615	COG1534	Rna-binding protein
BI316_RS10620	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BI316_RS10630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BI316_RS10635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI316_RS10645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BI316_RS10650	COG1546	Belongs to the CinA family
BI316_RS10660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI316_RS10665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BI316_RS10675	COG2137	regulation of response to DNA damage stimulus
BI316_RS10680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BI316_RS10685	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BI316_RS10705	COG1741	Belongs to the pirin family
BI316_RS10710	COG0583	DNA-binding transcription factor activity
BI316_RS10735	COG0352	thiamine-phosphate diphosphorylase activity
BI316_RS10735	COG0351	phosphomethylpyrimidine kinase
BI316_RS10750	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BI316_RS10755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BI316_RS10770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI316_RS10780	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BI316_RS10785	COG3734	2-keto-3-deoxy-galactonokinase
BI316_RS10795	COG4948	Mandelate Racemase Muconate Lactonizing
BI316_RS10800	COG0800	Aldolase
BI316_RS10840	COG1501	Belongs to the glycosyl hydrolase 31 family
BI316_RS10850	COG1070	Carbohydrate kinase
BI316_RS10855	COG2115	Belongs to the xylose isomerase family
BI316_RS10860	COG0477	Major facilitator Superfamily
BI316_RS10885	COG1469	GTP cyclohydrolase I activity
BI316_RS10905	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BI316_RS10910	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BI316_RS10915	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BI316_RS10920	COG0166	Belongs to the GPI family
BI316_RS10945	COG1472	Belongs to the glycosyl hydrolase 3 family
BI316_RS10960	COG5001	Diguanylate cyclase
BI316_RS10960	COG2203	Gaf domain
BI316_RS10960	COG4251	negative regulation of phosphorylation
BI316_RS10960	COG3706	GGDEF domain
BI316_RS10970	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI316_RS10975	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BI316_RS10990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BI316_RS10995	COG0671	phosphoesterase, PA-phosphatase related
BI316_RS11010	COG1794	racemase activity, acting on amino acids and derivatives
BI316_RS11015	COG0697	spore germination
BI316_RS11020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BI316_RS11025	COG0167	dihydroorotate dehydrogenase activity
BI316_RS11045	COG1012	belongs to the aldehyde dehydrogenase family
BI316_RS11060	COG1215	transferase activity, transferring glycosyl groups
BI316_RS11065	COG1649	PFAM Uncharacterised BCR, COG1649
BI316_RS11065	COG0726	polysaccharide deacetylase
BI316_RS11080	COG3210	domain, Protein
BI316_RS11090	COG3210	domain, Protein
BI316_RS11135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI316_RS11140	COG0124	histidyl-tRNA synthetase
BI316_RS11150	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BI316_RS11155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BI316_RS11160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI316_RS11165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BI316_RS11165	COG0131	Imidazoleglycerol-phosphate dehydratase
BI316_RS11170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BI316_RS11175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BI316_RS11180	COG0107	imidazoleglycerol-phosphate synthase activity
BI316_RS11185	COG0140	phosphoribosyl-ATP diphosphatase activity
BI316_RS11185	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BI316_RS11200	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BI316_RS11205	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BI316_RS11210	COG0235	Class ii aldolase
BI316_RS11215	COG0531	amino acid
BI316_RS11220	COG0531	amino acid
BI316_RS11230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI316_RS11235	COG0277	FAD linked oxidase domain protein
BI316_RS11255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI316_RS11300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI316_RS11305	COG2258	MOSC domain
BI316_RS11310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BI316_RS11315	COG0505	Belongs to the CarA family
BI316_RS11325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BI316_RS11330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI316_RS11340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BI316_RS11380	COG3279	Response regulator of the LytR AlgR family
BI316_RS11385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BI316_RS11390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BI316_RS11400	COG2198	Histidine kinase
BI316_RS11400	COG2205	protein histidine kinase activity
BI316_RS11400	COG0784	Response regulator, receiver
BI316_RS11405	COG1024	Enoyl-CoA hydratase
BI316_RS11410	COG0318	PFAM AMP-dependent synthetase and ligase
BI316_RS11440	COG2267	carboxylic ester hydrolase activity
BI316_RS11450	COG2201	protein-glutamate methylesterase activity
BI316_RS11455	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BI316_RS11465	COG0840	transmembrane signaling receptor activity
BI316_RS11475	COG0835	chemotaxis
BI316_RS11490	COG0840	transmembrane signaling receptor activity
BI316_RS11495	COG0840	transmembrane signaling receptor activity
BI316_RS11510	COG0840	transmembrane signaling receptor activity
BI316_RS11520	COG0840	transmembrane signaling receptor activity
BI316_RS11525	COG0840	transmembrane signaling receptor activity
BI316_RS11530	COG0840	transmembrane signaling receptor activity
BI316_RS11535	COG0840	transmembrane signaling receptor activity
BI316_RS11550	COG0840	transmembrane signaling receptor activity
BI316_RS11570	COG2198	Histidine kinase
BI316_RS11570	COG0643	Histidine kinase
BI316_RS11575	COG0745	RESPONSE REGULATOR receiver
BI316_RS11585	COG0835	chemotaxis
BI316_RS11595	COG1360	Flagellar Motor Protein
BI316_RS11600	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BI316_RS11675	COG3002	Belongs to the UPF0753 family
BI316_RS11715	COG0641	radical SAM
BI316_RS11735	COG0784	Response regulator, receiver
BI316_RS11735	COG2198	Histidine kinase
BI316_RS11735	COG0643	Histidine kinase
BI316_RS11765	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI316_RS11795	COG1684	flagellar biosynthetic protein fliR
BI316_RS11815	COG3190	flagellar
BI316_RS11865	COG1677	Flagellar hook-basal body complex protein FliE
BI316_RS11895	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS11905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI316_RS11925	COG2201	protein-glutamate methylesterase activity
BI316_RS11955	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BI316_RS11960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI316_RS11965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI316_RS11975	COG1705	Flagellar rod assembly protein muramidase FlgJ
BI316_RS11975	COG3951	Flagellar rod assembly protein muramidase FlgJ
BI316_RS11980	COG1706	bacterial-type flagellum-dependent cell motility
BI316_RS11985	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BI316_RS12000	COG4787	bacterial-type flagellum-dependent cell motility
BI316_RS12010	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BI316_RS12015	COG1558	bacterial-type flagellum-dependent cell motility
BI316_RS12025	COG0784	Response regulator, receiver
BI316_RS12025	COG0835	chemotaxis
BI316_RS12045	COG5002	protein histidine kinase activity
BI316_RS12075	COG2915	High frequency lysogenization protein hflD homolog
BI316_RS12080	COG0482	sulfurtransferase activity
BI316_RS12105	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BI316_RS12115	COG0492	ferredoxin-NADP+ reductase activity
BI316_RS12120	COG1674	ftsk spoiiie
BI316_RS12130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BI316_RS12140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BI316_RS12145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BI316_RS12155	COG0183	Belongs to the thiolase family
BI316_RS12160	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI316_RS12160	COG1024	Enoyl-CoA hydratase
BI316_RS12175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BI316_RS12185	COG1426	Protein conserved in bacteria
BI316_RS12195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI316_RS12200	COG1160	GTP binding
BI316_RS12205	COG0303	'Molybdopterin
BI316_RS12210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI316_RS12250	COG0708	Exodeoxyribonuclease III
BI316_RS12260	COG0303	'Molybdopterin
BI316_RS12265	COG0746	molybdenum cofactor guanylyltransferase activity
BI316_RS12280	COG1914	H( )-stimulated, divalent metal cation uptake system
BI316_RS12295	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BI316_RS12300	COG0668	transmembrane transport
BI316_RS12310	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BI316_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS12330	COG1183	phosphatidylcholine synthase activity
BI316_RS12340	COG3243	poly(R)-hydroxyalkanoic acid synthase
BI316_RS12355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI316_RS12355	COG0723	plastoquinol--plastocyanin reductase activity
BI316_RS12365	COG2183	response to ionizing radiation
BI316_RS12370	COG0784	Response regulator, receiver
BI316_RS12370	COG2205	protein histidine kinase activity
BI316_RS12450	COG0800	Aldolase
BI316_RS12455	COG0129	dihydroxy-acid dehydratase activity
BI316_RS12460	COG0363	glucosamine-6-phosphate deaminase activity
BI316_RS12465	COG0837	glucose binding
BI316_RS12470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI316_RS12495	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BI316_RS12510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BI316_RS12515	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BI316_RS12525	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI316_RS12530	COG1136	(ABC) transporter
BI316_RS12545	COG0811	peptide transport
BI316_RS12555	COG1132	(ABC) transporter
BI316_RS12560	COG1663	tetraacyldisaccharide 4'-kinase activity
BI316_RS12565	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BI316_RS12570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI316_RS12580	COG0322	excinuclease ABC activity
BI316_RS12585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BI316_RS12605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI316_RS12610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI316_RS12650	COG0582	viral genome integration into host DNA
BI316_RS12660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BI316_RS12680	COG1054	Belongs to the UPF0176 family
BI316_RS12690	COG1530	ribonuclease E activity
BI316_RS12700	COG3064	Membrane
BI316_RS12705	COG0428	transporter
BI316_RS12715	COG2154	pterin-4-alpha-carbinolamine dehydratase
BI316_RS12720	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BI316_RS12720	COG0316	Belongs to the HesB IscA family
BI316_RS12765	COG1073	alpha beta
BI316_RS12765	COG2226	methyltransferase
BI316_RS12775	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS12860	COG1238	metal cluster binding
BI316_RS12895	COG3279	Response regulator of the LytR AlgR family
BI316_RS12945	COG4566	intracellular signal transduction
BI316_RS12955	COG5001	Diguanylate cyclase
BI316_RS12975	COG3685	Protein conserved in bacteria
BI316_RS13000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI316_RS13000	COG1648	precorrin-2 dehydrogenase activity
BI316_RS13015	COG2814	Major facilitator Superfamily
BI316_RS13030	COG1335	isochorismatase
BI316_RS13045	COG2197	response regulator
BI316_RS13060	COG0583	DNA-binding transcription factor activity
BI316_RS13065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI316_RS13070	COG3002	Belongs to the UPF0753 family
BI316_RS13085	COG1396	sequence-specific DNA binding
BI316_RS13090	COG5489	Protein of unknown function (DUF736)
BI316_RS13095	COG2003	Belongs to the UPF0758 family
BI316_RS13120	COG0582	viral genome integration into host DNA
BI316_RS13135	COG4774	siderophore transport
BI316_RS13155	COG2336	PFAM SpoVT AbrB
BI316_RS13180	COG4206	TonB-dependent receptor
BI316_RS13220	COG2274	protein secretion by the type I secretion system
BI316_RS13275	COG0270	DNA (cytosine-5-)-methyltransferase activity
BI316_RS13325	COG4804	nuclease activity
BI316_RS13340	COG5006	permease, DMT superfamily
BI316_RS13355	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI316_RS13365	COG3938	Belongs to the proline racemase family
BI316_RS13380	COG2807	transmembrane transport
BI316_RS13385	COG2207	Transcriptional regulator
BI316_RS13535	COG0210	DNA helicase
BI316_RS13615	COG2084	Dehydrogenase
BI316_RS13635	COG2003	Belongs to the UPF0758 family
BI316_RS13670	COG0582	viral genome integration into host DNA
BI316_RS13675	COG0519	Catalyzes the synthesis of GMP from XMP
BI316_RS13675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI316_RS13685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BI316_RS13695	COG0475	glutathione-regulated potassium exporter activity
BI316_RS13695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI316_RS13700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BI316_RS13710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI316_RS13715	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BI316_RS13725	COG0776	regulation of translation
BI316_RS13730	COG0539	negative regulation of cytoplasmic translation
BI316_RS13735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BI316_RS13755	COG2957	Belongs to the agmatine deiminase family
BI316_RS13760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI316_RS13785	COG0395	ABC-type sugar transport system, permease component
BI316_RS13790	COG1175	transmembrane transport
BI316_RS13820	COG2350	Protein conserved in bacteria
BI316_RS13825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BI316_RS13830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BI316_RS13835	COG1187	pseudouridine synthase activity
BI316_RS13855	COG0436	Aminotransferase
BI316_RS13860	COG4133	protoheme IX ABC transporter activity
BI316_RS13880	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BI316_RS13885	COG1138	Cytochrome C-type biogenesis protein
BI316_RS13905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI316_RS13910	COG1278	Cold shock
BI316_RS13915	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BI316_RS13920	COG4988	ABC transporter
BI316_RS13930	COG1294	oxidase, subunit
BI316_RS13960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BI316_RS13975	COG0165	Argininosuccinate lyase
BI316_RS13980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BI316_RS13990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BI316_RS13995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI316_RS14005	COG0137	argininosuccinate synthase activity
BI316_RS14010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BI316_RS14020	COG0215	cysteine-tRNA ligase activity
BI316_RS14025	COG2166	iron-sulfur cluster assembly
BI316_RS14040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BI316_RS14045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BI316_RS14075	COG4302	ethanolamine ammonia-lyase activity
BI316_RS14110	COG2963	transposase activity
BI316_RS14140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BI316_RS14145	COG0402	S-adenosylhomocysteine deaminase activity
BI316_RS14155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI316_RS14160	COG1509	lysine 2,3-aminomutase activity
BI316_RS14165	COG3300	MHYT domain
BI316_RS14165	COG5001	Diguanylate cyclase
BI316_RS14180	COG0483	inositol monophosphate 1-phosphatase activity
BI316_RS14205	COG0488	(ABC) transporter
BI316_RS14210	COG0513	Belongs to the DEAD box helicase family
BI316_RS14215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI316_RS14220	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BI316_RS14230	COG0625	glutathione transferase activity
BI316_RS14240	COG4681	YaeQ
BI316_RS14245	COG2081	HI0933 family
BI316_RS14255	COG0501	Belongs to the peptidase M48B family
BI316_RS14260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI316_RS14265	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS14290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BI316_RS14295	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI316_RS14300	COG0802	atpase or kinase
BI316_RS14305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI316_RS14305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BI316_RS14310	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI316_RS14315	COG1570	exodeoxyribonuclease VII activity
BI316_RS14325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI316_RS14510	COG0835	chemotaxis
BI316_RS14515	COG0840	transmembrane signaling receptor activity
BI316_RS14520	COG2094	Belongs to the DNA glycosylase MPG family
BI316_RS14525	COG1201	RNA secondary structure unwinding
BI316_RS14545	COG2969	positive regulation of protein catabolic process
BI316_RS14550	COG0625	glutathione transferase activity
BI316_RS14555	COG2857	Cytochrome c1
BI316_RS14560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BI316_RS14565	COG0723	plastoquinol--plastocyanin reductase activity
BI316_RS14575	COG0741	lytic transglycosylase activity
BI316_RS14590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI316_RS14595	COG1702	phosphate starvation-inducible protein PhoH
BI316_RS14605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BI316_RS14615	COG4535	Mg2 and Co2 transporter CorC
BI316_RS14630	COG1012	belongs to the aldehyde dehydrogenase family
BI316_RS14635	COG1177	transmembrane transport
BI316_RS14640	COG1176	ABC-type spermidine putrescine transport system, permease component I
BI316_RS14645	COG3842	ATPase activity
BI316_RS14665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BI316_RS14680	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BI316_RS14685	COG0174	glutamine synthetase
BI316_RS14690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI316_RS14700	COG2703	oxygen carrier activity
BI316_RS14705	COG0477	Major facilitator Superfamily
BI316_RS14715	COG0243	molybdopterin cofactor binding
BI316_RS14720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BI316_RS14725	COG2223	nitrite transmembrane transporter activity
BI316_RS14740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BI316_RS14750	COG2733	membrane
BI316_RS14755	COG0784	Response regulator, receiver
BI316_RS14755	COG2205	protein histidine kinase activity
BI316_RS14755	COG5002	protein histidine kinase activity
BI316_RS14765	COG0477	Major facilitator Superfamily
BI316_RS14775	COG2902	Dehydrogenase
BI316_RS14785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI316_RS14790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI316_RS14795	COG1609	Transcriptional regulator
BI316_RS14800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI316_RS14800	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI316_RS14805	COG1105	Belongs to the carbohydrate kinase PfkB family
BI316_RS14810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI316_RS14810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI316_RS14855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI316_RS14865	COG1862	Preprotein translocase
BI316_RS14870	COG0343	queuine tRNA-ribosyltransferase activity
BI316_RS14875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BI316_RS14910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BI316_RS14915	COG3291	Pkd domain containing protein
BI316_RS14920	COG0405	Gamma-glutamyltransferase
BI316_RS14925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BI316_RS14940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BI316_RS14945	COG0742	ribosomal rna small subunit methyltransferase
BI316_RS14950	COG0326	Molecular chaperone. Has ATPase activity
BI316_RS15030	COG0531	amino acid
BI316_RS15045	COG0006	proline dipeptidase activity
BI316_RS15055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI316_RS15070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI316_RS15075	COG3938	Belongs to the proline racemase family
BI316_RS15085	COG0552	protein localization to endoplasmic reticulum
BI316_RS15095	COG1194	a g-specific adenine glycosylase
BI316_RS15100	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BI316_RS15105	COG0784	Response regulator, receiver
BI316_RS15105	COG4191	Histidine kinase
BI316_RS15120	COG0322	excinuclease ABC activity
BI316_RS15135	COG3040	lipid binding
BI316_RS15150	COG1960	acyl-CoA dehydrogenase activity
BI316_RS15160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BI316_RS15180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI316_RS15185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI316_RS15190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI316_RS15215	COG0438	transferase activity, transferring glycosyl groups
BI316_RS15225	COG0438	transferase activity, transferring glycosyl groups
BI316_RS15230	COG0438	transferase activity, transferring glycosyl groups
BI316_RS15280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI316_RS15280	COG0072	phenylalanine-tRNA ligase activity
BI316_RS15285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BI316_RS15300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BI316_RS15305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BI316_RS15330	COG1082	Xylose isomerase domain protein TIM barrel
BI316_RS15360	COG0366	Alpha amylase catalytic
BI316_RS15425	COG3702	type iv secretory pathway
BI316_RS15445	COG2948	multi-organism process
BI316_RS15465	COG3505	Type IV secretory pathway VirD4
BI316_RS15480	COG0556	nucleotide-excision repair
BI316_RS15595	COG4695	Portal protein
BI316_RS15640	COG3179	chitinase
BI316_RS15740	COG3275	phosphorelay sensor kinase activity
BI316_RS15745	COG1611	Belongs to the LOG family
BI316_RS15760	COG2095	MarC family integral membrane protein
BI316_RS15770	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI316_RS15805	COG1185	polyribonucleotide nucleotidyltransferase activity
BI316_RS15810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BI316_RS15815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BI316_RS15820	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BI316_RS15825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BI316_RS15830	COG0195	Participates in both transcription termination and antitermination
BI316_RS15835	COG0779	Required for maturation of 30S ribosomal subunits
BI316_RS15845	COG1007	ATP synthesis coupled electron transport
BI316_RS15870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI316_RS15875	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BI316_RS15885	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BI316_RS15890	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BI316_RS15895	COG0649	NAD binding
BI316_RS15900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI316_RS15905	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI316_RS15910	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI316_RS15925	COG0149	triose-phosphate isomerase activity
BI316_RS15930	COG0300	oxidoreductase activity
BI316_RS15960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI316_RS15965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BI316_RS15970	COG0159	tryptophan synthase activity
BI316_RS15980	COG0133	tryptophan synthase activity
BI316_RS15990	COG0135	phosphoribosylanthranilate isomerase activity
BI316_RS15995	COG0101	tRNA pseudouridine synthase activity
BI316_RS16020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BI316_RS16025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI316_RS16030	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BI316_RS16035	COG2890	protein-(glutamine-N5) methyltransferase activity
BI316_RS16045	COG0688	phosphatidylethanolamine metabolic process
BI316_RS16060	COG0433	COG0433 Predicted ATPase
BI316_RS16065	COG0494	nUDIX hydrolase
BI316_RS16085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI316_RS16090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI316_RS16115	COG0717	Belongs to the dCTP deaminase family
BI316_RS16125	COG0489	protein tyrosine kinase activity
BI316_RS16145	COG3590	peptidase
BI316_RS16155	COG3590	peptidase
BI316_RS16175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI316_RS16180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI316_RS16185	COG2311	Membrane
BI316_RS16190	COG1047	Peptidyl-prolyl cis-trans
BI316_RS16195	COG0791	NLP P60 protein
BI316_RS16200	COG0791	NLP P60 protein
BI316_RS16210	COG4106	trans-aconitate 2-methyltransferase activity
BI316_RS16215	COG1301	dicarboxylic acid transport
BI316_RS16220	COG1785	Belongs to the alkaline phosphatase family
BI316_RS16230	COG0037	tRNA processing
BI316_RS16235	COG1722	exodeoxyribonuclease VII activity
BI316_RS16240	COG0142	geranyltranstransferase activity
BI316_RS16245	COG4104	PAAR repeat-containing protein
BI316_RS16255	COG0312	modulator of DNA gyrase
BI316_RS16260	COG3028	Belongs to the UPF0307 family
BI316_RS16265	COG0312	modulator of DNA gyrase
BI316_RS16275	COG3164	Protein of unknown function
BI316_RS16285	COG0424	maF-like protein
BI316_RS16290	COG2968	Membrane
BI316_RS16305	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BI316_RS16320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BI316_RS16335	COG0495	leucyl-tRNA aminoacylation
BI316_RS16345	COG3118	belongs to the thioredoxin family
BI316_RS16375	COG2155	Conserved Protein
BI316_RS16420	COG1132	(ABC) transporter
BI316_RS16450	COG1538	Outer membrane efflux protein
BI316_RS16455	COG0745	RESPONSE REGULATOR receiver
BI316_RS16460	COG5000	phosphorelay sensor kinase activity
BI316_RS16460	COG5002	protein histidine kinase activity
BI316_RS16465	COG0475	glutathione-regulated potassium exporter activity
BI316_RS16475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI316_RS16500	COG1187	pseudouridine synthase activity
BI316_RS16505	COG5002	protein histidine kinase activity
BI316_RS16505	COG5001	Diguanylate cyclase
BI316_RS16625	COG0667	Aldo Keto reductase
BI316_RS16635	COG2814	Major facilitator Superfamily
BI316_RS16640	COG0583	DNA-binding transcription factor activity
BI316_RS16650	COG2207	Transcriptional regulator
BI316_RS16660	COG1309	transcriptional regulator
BI316_RS16685	COG0735	belongs to the Fur family
BI316_RS16690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI316_RS16715	COG4452	Inner membrane protein CreD
BI316_RS16725	COG2205	protein histidine kinase activity
BI316_RS16730	COG0745	RESPONSE REGULATOR receiver
BI316_RS16735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BI316_RS16745	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BI316_RS16780	COG0643	Histidine kinase
BI316_RS16780	COG2198	Histidine kinase
BI316_RS16790	COG0840	transmembrane signaling receptor activity
BI316_RS16795	COG0835	chemotaxis
BI316_RS16800	COG2199	diguanylate cyclase activity
BI316_RS16800	COG2200	EAL domain
BI316_RS16800	COG2202	Pas domain
BI316_RS16805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI316_RS16810	COG2201	protein-glutamate methylesterase activity
BI316_RS16815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI316_RS16820	COG3590	peptidase
BI316_RS16830	COG0588	phosphoglycerate mutase activity
BI316_RS16835	COG1515	deoxyribonuclease V activity
BI316_RS16845	COG1741	Belongs to the pirin family
BI316_RS16860	COG1741	Belongs to the pirin family
BI316_RS16865	COG1966	Carbon starvation protein
BI316_RS16870	COG2879	small protein
BI316_RS16915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI316_RS16920	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI316_RS16925	COG2080	2 iron, 2 sulfur cluster binding
BI316_RS16935	COG2203	Gaf domain
BI316_RS16935	COG3706	GGDEF domain
BI316_RS16935	COG4251	negative regulation of phosphorylation
BI316_RS16935	COG5001	Diguanylate cyclase
BI316_RS16940	COG0629	single-stranded DNA binding
BI316_RS16945	COG0142	geranyltranstransferase activity
BI316_RS16960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BI316_RS16975	COG0527	aspartate kinase activity
BI316_RS16980	COG0384	phenazine biosynthesis protein PhzF
BI316_RS16985	COG0384	phenazine biosynthesis protein PhzF
BI316_RS16995	COG1764	response to oxidative stress
BI316_RS17000	COG0540	Belongs to the ATCase OTCase family
BI316_RS17005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BI316_RS17010	COG1678	Uncharacterized ACR, COG1678
BI316_RS17020	COG0519	Catalyzes the synthesis of GMP from XMP
BI316_RS17030	COG5297	Belongs to the glycosyl hydrolase family 6
BI316_RS17045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BI316_RS17060	COG0739	heme binding
BI316_RS17080	COG0693	protein deglycase activity
BI316_RS17090	COG1959	2 iron, 2 sulfur cluster binding
BI316_RS17095	COG0719	Fe-S assembly protein
BI316_RS17100	COG0396	ATPase activity
BI316_RS17105	COG0719	Fe-S assembly protein
BI316_RS17110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BI316_RS17120	COG2146	nitrite reductase [NAD(P)H] activity
BI316_RS17125	COG4774	siderophore transport
BI316_RS17130	COG3128	pkhd-type hydroxylase
BI316_RS17155	COG1477	protein flavinylation
BI316_RS17160	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI316_RS17175	COG1555	photosystem II stabilization
BI316_RS17180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI316_RS17190	COG3178	'Phosphotransferase
BI316_RS17195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BI316_RS17205	COG0628	permease
BI316_RS17215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BI316_RS17225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BI316_RS17245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BI316_RS17250	COG0271	Belongs to the BolA IbaG family
BI316_RS17260	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BI316_RS17270	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BI316_RS17275	COG1137	ATPase activity
BI316_RS17290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI316_RS17295	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BI316_RS17300	COG1660	Displays ATPase and GTPase activities
BI316_RS17310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI316_RS17315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI316_RS17320	COG2239	Acts as a magnesium transporter
BI316_RS17335	COG1294	oxidase, subunit
BI316_RS17340	COG1271	oxidase subunit
BI316_RS17350	COG1113	amino acid transport
BI316_RS17380	COG2197	response regulator
BI316_RS17385	COG0531	amino acid
BI316_RS17420	COG1234	tRNA 3'-trailer cleavage
BI316_RS17465	COG2814	Major facilitator Superfamily
BI316_RS17475	COG0754	glutathionylspermidine amidase activity
BI316_RS17500	COG1842	Phage shock protein A
BI316_RS17510	COG0259	pyridoxamine-phosphate oxidase activity
BI316_RS17515	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BI316_RS17520	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BI316_RS17530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BI316_RS17605	COG2814	Major facilitator Superfamily
BI316_RS17630	COG0784	Response regulator, receiver
BI316_RS17630	COG2205	protein histidine kinase activity
BI316_RS17630	COG2198	Histidine kinase
BI316_RS17635	COG2353	YceI-like domain
BI316_RS17655	COG1760	l-serine dehydratase
BI316_RS17670	COG0527	aspartate kinase activity
BI316_RS17670	COG0460	homoserine dehydrogenase
BI316_RS17675	COG0626	cystathionine gamma-synthase activity
BI316_RS17680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI316_RS17685	COG0739	heme binding
BI316_RS17690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BI316_RS17695	COG1272	protein, Hemolysin III
BI316_RS17700	COG2982	Protein involved in outer membrane biogenesis
BI316_RS17705	COG0516	GMP reductase activity
BI316_RS17705	COG0517	IMP dehydrogenase activity
BI316_RS17710	COG0463	Glycosyl transferase, family 2
BI316_RS17715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI316_RS17720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BI316_RS17730	COG4771	TonB-dependent receptor
BI316_RS17740	COG1309	transcriptional regulator
BI316_RS17750	COG1960	acyl-CoA dehydrogenase activity
BI316_RS17775	COG0509	glycine decarboxylation via glycine cleavage system
BI316_RS17780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BI316_RS17790	COG0330	HflC and HflK could
BI316_RS17795	COG1742	UPF0060 membrane protein
BI316_RS17800	COG3956	TIGRFAM MazG family protein
BI316_RS17810	COG0494	nUDIX hydrolase
BI316_RS17820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BI316_RS17825	COG0837	glucose binding
BI316_RS17840	COG3858	chitin binding
BI316_RS17840	COG1388	LysM domain
BI316_RS17855	COG1472	Belongs to the glycosyl hydrolase 3 family
BI316_RS17870	COG0531	amino acid
BI316_RS17880	COG1486	melibiose metabolic process
BI316_RS17890	COG3537	Alpha-1,2-mannosidase
BI316_RS17930	COG3142	Participates in the control of copper homeostasis
BI316_RS17935	COG1446	asparaginase
BI316_RS17970	COG2198	Histidine kinase
BI316_RS17970	COG0784	Response regulator, receiver
BI316_RS17970	COG0643	Histidine kinase
BI316_RS17975	COG0840	transmembrane signaling receptor activity
BI316_RS17980	COG0835	chemotaxis
BI316_RS17995	COG0189	ligase activity
BI316_RS18005	COG1397	ADP-ribosylglycohydrolase
BI316_RS18015	COG1199	ATP-dependent helicase activity
BI316_RS18025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI316_RS18030	COG1215	transferase activity, transferring glycosyl groups
BI316_RS18045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI316_RS18055	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BI316_RS18060	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BI316_RS18065	COG0535	radical SAM domain protein
BI316_RS18070	COG0535	radical SAM domain protein
BI316_RS18085	COG0837	glucose binding
BI316_RS18100	COG1643	Atp-dependent helicase
BI316_RS18105	COG0783	Belongs to the Dps family
BI316_RS18115	COG0514	ATP-dependent DNA helicase (RecQ)
BI316_RS18150	COG0840	transmembrane signaling receptor activity
BI316_RS18170	COG3920	Histidine kinase
BI316_RS18175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BI316_RS18185	COG0602	queuosine metabolic process
BI316_RS18195	COG2885	chlorophyll binding
BI316_RS18200	COG0823	Involved in the tonB-independent uptake of proteins
BI316_RS18210	COG0848	biopolymer transport protein
BI316_RS18220	COG0824	Thioesterase
BI316_RS18225	COG2255	four-way junction helicase activity
BI316_RS18235	COG3158	transport of potassium into the cell
BI316_RS18240	COG0632	four-way junction helicase activity
BI316_RS18245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BI316_RS18250	COG0217	transcriptional regulatory protein
BI316_RS18265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BI316_RS18280	COG0477	Major facilitator Superfamily
BI316_RS18325	COG0488	(ABC) transporter
BI316_RS18365	COG4651	solute:proton antiporter activity
BI316_RS18365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI316_RS18390	COG4772	TonB-dependent receptor
BI316_RS18400	COG4264	IucA IucC family
BI316_RS18415	COG0019	diaminopimelate decarboxylase activity
BI316_RS18440	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BI316_RS18450	COG1492	cobalamin metabolic process
BI316_RS18460	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI316_RS18480	COG4206	TonB-dependent receptor
BI316_RS18485	COG0542	response to heat
BI316_RS18490	COG1116	anion transmembrane transporter activity
BI316_RS18495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI316_RS18500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI316_RS18505	COG0667	Aldo Keto reductase
BI316_RS18510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI316_RS18515	COG4771	TonB-dependent receptor
BI316_RS18520	COG2827	Endonuclease containing a URI domain
BI316_RS18560	COG1877	trehalose-phosphatase activity
BI316_RS18565	COG3387	PFAM Glycoside hydrolase 15-related
BI316_RS18585	COG0840	transmembrane signaling receptor activity
BI316_RS18590	COG3011	Protein conserved in bacteria
BI316_RS18605	COG0564	pseudouridine synthase activity
BI316_RS18610	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI316_RS18620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI316_RS18620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BI316_RS18650	COG2951	lytic endotransglycosylase activity
BI316_RS18680	COG2369	cell adhesion
BI316_RS18705	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BI316_RS18710	COG0045	succinate-CoA ligase (ADP-forming) activity
BI316_RS18725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI316_RS18760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BI316_RS18765	COG0237	dephospho-CoA kinase activity
BI316_RS18795	COG5002	protein histidine kinase activity
BI316_RS18800	COG0745	RESPONSE REGULATOR receiver
BI316_RS18885	COG2003	Belongs to the UPF0758 family
BI316_RS18910	COG4191	Histidine kinase
BI316_RS18910	COG0784	Response regulator, receiver
BI316_RS18915	COG0784	Response regulator, receiver
BI316_RS18915	COG4191	Histidine kinase
BI316_RS19040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BI316_RS19070	COG2022	thiamine diphosphate biosynthetic process
BI316_RS19080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BI316_RS19085	COG0471	metal ion transport
BI316_RS19085	COG3273	potassium ion transport
BI316_RS19110	COG1970	mechanosensitive ion channel activity
BI316_RS19120	COG1609	Transcriptional regulator
BI316_RS19130	COG3250	beta-galactosidase activity
BI316_RS19135	COG4948	Mandelate Racemase Muconate Lactonizing
BI316_RS19150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI316_RS19160	COG0308	aminopeptidase N
BI316_RS19200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI316_RS19210	COG0529	Catalyzes the synthesis of activated sulfate
BI316_RS19210	COG2895	sulfate adenylyltransferase (ATP) activity
BI316_RS19215	COG0175	sulfate reduction
BI316_RS19220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI316_RS19225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI316_RS19230	COG0175	sulfate reduction
BI316_RS19250	COG2198	Histidine kinase
BI316_RS19250	COG2205	protein histidine kinase activity
BI316_RS19250	COG0784	Response regulator, receiver
BI316_RS19270	COG1648	precorrin-2 dehydrogenase activity
BI316_RS19270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI316_RS19285	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BI316_RS19290	COG3588	fructose-bisphosphate aldolase
BI316_RS19305	COG0469	pyruvate kinase activity
BI316_RS19315	COG0126	phosphoglycerate kinase activity
BI316_RS19340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BI316_RS19350	COG3047	cAMP biosynthetic process
BI316_RS19355	COG3047	cAMP biosynthetic process
BI316_RS19365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI316_RS19365	COG3453	Protein conserved in bacteria
BI316_RS19370	COG0725	ABC transporter, periplasmic molybdate-binding protein
BI316_RS19375	COG4149	molybdate abc transporter
BI316_RS19380	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BI316_RS19415	COG1376	ErfK ybiS ycfS ynhG family protein
BI316_RS19430	COG4773	Receptor
BI316_RS19435	COG0596	Alpha beta hydrolase
BI316_RS19440	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BI316_RS19445	COG1301	dicarboxylic acid transport
BI316_RS19460	COG2304	oxidoreductase activity
BI316_RS19480	COG0714	Associated with various cellular activities
BI316_RS19515	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BI316_RS19540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI316_RS19550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI316_RS19560	COG0194	GDP metabolic process
BI316_RS19565	COG1561	YicC-like family, N-terminal region
BI316_RS19570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BI316_RS19580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BI316_RS19585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BI316_RS19600	COG0006	proline dipeptidase activity
BI316_RS19610	COG0006	proline dipeptidase activity
BI316_RS19615	COG3079	Belongs to the UPF0149 family
BI316_RS19635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BI316_RS19645	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BI316_RS19655	COG2912	Transglutaminase-like superfamily
BI316_RS19660	COG1773	rubredoxin
BI316_RS19665	COG0352	thiamine-phosphate diphosphorylase activity
BI316_RS19680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BI316_RS19695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI316_RS19725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BI316_RS19730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI316_RS19740	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS19750	COG0671	phosphoesterase, PA-phosphatase related
BI316_RS19755	COG3781	membrane
BI316_RS19765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI316_RS19770	COG0563	adenylate kinase activity
BI316_RS19785	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BI316_RS19795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BI316_RS19815	COG3710	Transcriptional regulator
BI316_RS19820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BI316_RS19835	COG0840	transmembrane signaling receptor activity
BI316_RS19840	COG0405	Gamma-glutamyltransferase
BI316_RS19845	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BI316_RS19870	COG0473	3-isopropylmalate dehydrogenase activity
BI316_RS19875	COG0066	3-isopropylmalate dehydratase activity
BI316_RS19880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BI316_RS19900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI316_RS19905	COG1538	Outer membrane efflux protein
BI316_RS19910	COG1519	Transferase
BI316_RS19920	COG1560	Kdo2-lipid A biosynthetic process
BI316_RS19945	COG0281	malic enzyme
BI316_RS19945	COG0280	phosphate acetyltransferase
BI316_RS19950	COG1301	dicarboxylic acid transport
BI316_RS19975	COG0583	DNA-binding transcription factor activity
BI316_RS19985	COG0667	Aldo Keto reductase
BI316_RS20000	COG2197	response regulator
BI316_RS20015	COG0642	Histidine kinase
BI316_RS20035	COG2851	Citrate transporter
BI316_RS20040	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS20045	COG1609	Transcriptional regulator
BI316_RS20050	COG2211	Major facilitator Superfamily
BI316_RS20075	COG1162	GTPase activity
BI316_RS20105	COG4773	Receptor
BI316_RS20110	COG0726	polysaccharide deacetylase
BI316_RS20115	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI316_RS20160	COG1307	EDD domain protein, DegV family
BI316_RS20165	COG0242	peptide deformylase activity
BI316_RS20195	COG0457	Tetratricopeptide repeat
BI316_RS20200	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BI316_RS20205	COG1215	transferase activity, transferring glycosyl groups
BI316_RS20210	COG1215	transferase activity, transferring glycosyl groups
BI316_RS20225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BI316_RS20280	COG2188	Transcriptional regulator
BI316_RS20290	COG1450	Type ii and iii secretion system protein
BI316_RS20305	COG3166	PFAM Fimbrial assembly family protein
BI316_RS20310	COG3156	type II secretion system protein K
BI316_RS20315	COG4795	General secretion pathway protein
BI316_RS20320	COG2165	general secretion pathway protein
BI316_RS20325	COG4970	Tfp pilus assembly protein FimT
BI316_RS20330	COG2165	general secretion pathway protein
BI316_RS20335	COG1459	type II secretion system
BI316_RS20345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI316_RS20350	COG1404	Belongs to the peptidase S8 family
BI316_RS20355	COG5295	Hep Hag repeat protein
BI316_RS20360	COG1404	Belongs to the peptidase S8 family
BI316_RS20365	COG5295	Hep Hag repeat protein
BI316_RS20375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BI316_RS20375	COG0047	phosphoribosylformylglycinamidine synthase activity
BI316_RS20390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI316_RS20400	COG4974	Belongs to the 'phage' integrase family
BI316_RS20415	COG0795	lipopolysaccharide-transporting ATPase activity
BI316_RS20425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI316_RS20440	COG0525	valine-tRNA ligase activity
BI316_RS20470	COG1183	phosphatidylcholine synthase activity
BI316_RS20480	COG0442	prolyl-tRNA aminoacylation
BI316_RS20495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI316_RS20500	COG1127	ABC transporter
BI316_RS20505	COG3218	ABC-type transport auxiliary lipoprotein component
BI316_RS20505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI316_RS20540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI316_RS20545	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BI316_RS20545	COG0662	Cupin 2, conserved barrel domain protein
BI316_RS20580	COG2086	electron transfer activity
BI316_RS20595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BI316_RS20595	COG0546	phosphoglycolate phosphatase activity
BI316_RS20600	COG0277	FAD linked oxidase domain protein
BI316_RS20615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI316_RS20645	COG0438	transferase activity, transferring glycosyl groups
BI316_RS20645	COG1216	Glycosyl transferase, family 2
BI316_RS20665	COG0626	cystathionine gamma-synthase activity
BI316_RS20700	COG0625	glutathione transferase activity
BI316_RS20715	COG0513	Belongs to the DEAD box helicase family
BI316_RS20725	COG4206	TonB-dependent receptor
BI316_RS20735	COG0720	synthase
BI316_RS20745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BI316_RS20750	COG1956	GAF domain-containing protein
BI316_RS20760	COG2819	hydrolase of the alpha beta superfamily
BI316_RS20775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI316_RS20780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI316_RS20795	COG0339	signal peptide processing
BI316_RS20850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI316_RS20855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI316_RS20860	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI316_RS20860	COG1136	(ABC) transporter
BI316_RS20865	COG0577	efflux transmembrane transporter activity
BI316_RS20865	COG1136	(ABC) transporter
BI316_RS20870	COG0577	efflux transmembrane transporter activity
BI316_RS20885	COG4191	Histidine kinase
BI316_RS20890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BI316_RS20905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BI316_RS20910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BI316_RS20915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BI316_RS20920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BI316_RS20925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BI316_RS20930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BI316_RS20940	COG0356	it plays a direct role in the translocation of protons across the membrane
BI316_RS20960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI316_RS20970	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI316_RS21010	COG2011	ABC-type metal ion transport system permease component
BI316_RS21015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI316_RS21020	COG0697	spore germination
BI316_RS21025	COG1666	GTP binding
BI316_RS21035	COG5002	protein histidine kinase activity
BI316_RS21035	COG0784	Response regulator, receiver
BI316_RS21035	COG2198	Histidine kinase
BI316_RS21055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI316_RS21060	COG1187	pseudouridine synthase activity
BI316_RS21065	COG2813	Specifically methylates the guanine in position
BI316_RS21085	COG2205	protein histidine kinase activity
BI316_RS21085	COG2202	Pas domain
BI316_RS21105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BI316_RS21110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI316_RS21170	COG0842	Transport permease protein
BI316_RS21175	COG1131	(ABC) transporter
BI316_RS21180	COG0025	NhaP-type Na H and K H
BI316_RS21190	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BI316_RS21195	COG1573	uracil-dna glycosylase
BI316_RS21205	COG3384	dioxygenase
BI316_RS21215	COG0583	DNA-binding transcription factor activity
BI316_RS21225	COG0667	Aldo Keto reductase
BI316_RS21260	COG0531	amino acid
BI316_RS21275	COG2972	Histidine kinase
BI316_RS21300	COG3685	Protein conserved in bacteria
BI316_RS21305	COG3546	catalase activity
BI316_RS21355	COG1271	oxidase subunit
BI316_RS21360	COG1294	oxidase, subunit
BI316_RS21375	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS21380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BI316_RS21400	COG1132	(ABC) transporter
BI316_RS21415	COG1063	alcohol dehydrogenase
BI316_RS21490	COG0251	oxidation-reduction process
BI316_RS21525	COG0840	transmembrane signaling receptor activity
BI316_RS21545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI316_RS21590	COG0024	Methionine aminopeptidase
BI316_RS21625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI316_RS21630	COG1490	D-aminoacyl-tRNA deacylase activity
BI316_RS21635	COG1560	Kdo2-lipid A biosynthetic process
BI316_RS21690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BI316_RS21690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI316_RS21695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BI316_RS21700	COG0242	peptide deformylase activity
BI316_RS21705	COG1652	LysM domain
BI316_RS21710	COG0758	DNA mediated transformation
BI316_RS21715	COG2922	Belongs to the Smg family
BI316_RS21730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI316_RS21730	COG1754	DNA topoisomerase type I activity
BI316_RS21735	COG0009	L-threonylcarbamoyladenylate synthase
BI316_RS21750	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS21760	COG0616	signal peptide processing
BI316_RS21765	COG0534	Mate efflux family protein
BI316_RS21785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BI316_RS21790	COG0625	glutathione transferase activity
BI316_RS21805	COG1252	NADH dehydrogenase
BI316_RS21810	COG2860	membrane
BI316_RS21815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI316_RS21820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BI316_RS21825	COG3437	response regulator, receiver
BI316_RS21830	COG2177	Part of the ABC transporter FtsEX involved in
BI316_RS21835	COG2884	Cell division ATP-binding protein ftsE
BI316_RS21840	COG0513	Belongs to the DEAD box helicase family
BI316_RS21845	COG3118	belongs to the thioredoxin family
BI316_RS21850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BI316_RS21855	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BI316_RS21860	COG0583	DNA-binding transcription factor activity
BI316_RS21905	COG1518	maintenance of DNA repeat elements
BI316_RS21910	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BI316_RS21920	COG1652	LysM domain
BI316_RS21925	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI316_RS21925	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI316_RS21930	COG1473	amidohydrolase
BI316_RS21935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI316_RS21940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI316_RS21950	COG5383	Protein conserved in bacteria
BI316_RS21995	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BI316_RS22000	COG3023	N-Acetylmuramoyl-L-alanine amidase
BI316_RS22010	COG4948	Mandelate Racemase Muconate Lactonizing
BI316_RS22020	COG0531	amino acid
BI316_RS22035	COG4682	membrane
BI316_RS22040	COG2133	pyrroloquinoline quinone binding
BI316_RS22050	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BI316_RS22055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BI316_RS22065	COG1610	YqeY-like protein
BI316_RS22075	COG1295	ribonuclease BN
BI316_RS22080	COG0358	DNA primase activity
BI316_RS22095	COG0109	protoheme IX farnesyltransferase activity
BI316_RS22125	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BI316_RS22140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BI316_RS22185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BI316_RS22190	COG0739	heme binding
BI316_RS22195	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BI316_RS22205	COG2211	Major facilitator Superfamily
BI316_RS22210	COG0708	Exodeoxyribonuclease III
BI316_RS22215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BI316_RS22225	COG1192	Involved in chromosome partitioning
BI316_RS22230	COG1475	DNA binding
BI316_RS22250	COG0463	Glycosyl transferase, family 2
BI316_RS22270	COG0756	dUTP diphosphatase activity
BI316_RS22275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BI316_RS22280	COG2003	Belongs to the UPF0758 family
BI316_RS22285	COG0018	arginyl-trna synthetase
BI316_RS22300	COG4221	oxidoreductase activity
BI316_RS22305	COG2755	lipolytic protein G-D-S-L family
BI316_RS22305	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI316_RS22315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI316_RS22320	COG1166	arginine decarboxylase activity
BI316_RS22325	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BI316_RS22365	COG0606	chelatase, subunit chli
BI316_RS22380	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BI316_RS22420	COG1690	Belongs to the RtcB family
BI316_RS22455	COG1090	epimerase
BI316_RS22465	COG0642	Histidine kinase
BI316_RS22495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI316_RS22520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI316_RS22525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI316_RS22540	COG0753	catalase activity
BI316_RS22555	COG2197	response regulator
BI316_RS22560	COG4585	Histidine kinase
BI316_RS22565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI316_RS22570	COG1136	(ABC) transporter
BI316_RS22595	COG0697	spore germination
BI316_RS22615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI316_RS22620	COG0180	Tryptophanyl-tRNA synthetase
BI316_RS22625	COG3237	CsbD-like
BI316_RS22670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BI316_RS22685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BI316_RS22735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI316_RS22775	COG1199	ATP-dependent helicase activity
BI316_RS22790	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BI316_RS22855	COG0625	glutathione transferase activity
BI316_RS22900	COG4555	ABC transporter
BI316_RS22910	COG1476	TRANSCRIPTIONal
BI316_RS22955	COG0633	Ferredoxin
BI316_RS22955	COG0543	2 iron, 2 sulfur cluster binding
BI316_RS22960	COG1131	(ABC) transporter
BI316_RS22965	COG0842	Transport permease protein
BI316_RS22975	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BI316_RS23010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI316_RS23020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI316_RS23035	COG1042	CoA-binding domain protein
BI316_RS23035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI316_RS23035	COG0045	succinate-CoA ligase (ADP-forming) activity
BI316_RS23040	COG2239	Acts as a magnesium transporter
BI316_RS23060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI316_RS23065	COG3387	PFAM Glycoside hydrolase 15-related
BI316_RS23080	COG3100	YcgL domain-containing protein
BI316_RS23085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BI316_RS23095	COG0463	Glycosyl transferase, family 2
BI316_RS23115	COG1028	Short-chain dehydrogenase reductase Sdr
BI316_RS23155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI316_RS23170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI316_RS23200	COG1506	peptidase
BI316_RS23200	COG4946	Tricorn protease homolog
BI316_RS23200	COG0823	Involved in the tonB-independent uptake of proteins
BI316_RS23220	COG0408	coproporphyrinogen oxidase activity
BI316_RS23260	COG0515	serine threonine protein kinase
BI316_RS23260	COG2815	serine threonine protein kinase
BI316_RS23265	COG0631	protein serine/threonine phosphatase activity
BI316_RS23630	COG1199	ATP-dependent helicase activity
BI316_RS23640	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BI316_RS23650	COG0745	RESPONSE REGULATOR receiver
BI316_RS23785	COG1475	DNA binding
BI316_RS23820	COG0629	single-stranded DNA binding
BI316_RS23845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI316_RS23940	COG4232	protein-disulfide reductase activity
BI316_RS24030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI316_RS24035	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI316_RS24050	COG0010	Belongs to the arginase family
BI316_RS24105	COG2132	Multicopper oxidase
BI316_RS24135	COG0653	protein targeting
BI316_RS24160	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BI316_RS24175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI316_RS24185	COG0431	NADPH-dependent FMN reductase
BI316_RS24190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BI316_RS24235	COG4644	lycopene metabolic process
BI316_RS24260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI316_RS24540	COG2951	lytic endotransglycosylase activity
BI316_RS24585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI316_RS24605	COG3318	Belongs to the UPF0149 family
BI316_RS24605	COG3012	SEC-C Motif Domain Protein
BI316_RS24670	COG3012	SEC-C Motif Domain Protein
BI316_RS24670	COG3318	Belongs to the UPF0149 family
BI316_RS24705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI316_RS24710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI316_RS24715	COG4456	Virulence-associated protein
BI316_RS24830	COG3504	Conjugal transfer protein
BI316_RS24835	COG2948	multi-organism process
BI316_RS24870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI316_RS24970	COG1475	DNA binding
BI316_RS25050	COG1192	Involved in chromosome partitioning
BI316_RS25070	COG3012	SEC-C Motif Domain Protein
BI316_RS25070	COG3318	Belongs to the UPF0149 family
BI316_RS25090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI316_RS25415	COG1525	nuclease