locus-tag	class	description
BI314_RS00005	COG4807	Protein conserved in bacteria
BI314_RS00015	COG1643	Atp-dependent helicase
BI314_RS00030	COG1187	pseudouridine synthase activity
BI314_RS00045	COG2130	NADP-dependent
BI314_RS00075	COG1764	response to oxidative stress
BI314_RS00080	COG1846	Transcriptional regulator
BI314_RS00085	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BI314_RS00095	COG0697	spore germination
BI314_RS00105	COG0523	cobalamin synthesis protein
BI314_RS00165	COG1960	acyl-CoA dehydrogenase activity
BI314_RS00170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI314_RS00175	COG4770	biotin carboxylase activity
BI314_RS00205	COG2224	Isocitrate lyase
BI314_RS00210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BI314_RS00215	COG0583	DNA-binding transcription factor activity
BI314_RS00220	COG0475	glutathione-regulated potassium exporter activity
BI314_RS00250	COG0339	signal peptide processing
BI314_RS00275	COG0564	pseudouridine synthase activity
BI314_RS00285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI314_RS00300	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI314_RS00315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI314_RS00320	COG0318	PFAM AMP-dependent synthetase and ligase
BI314_RS00325	COG0727	PFAM Uncharacterised protein family (UPF0153)
BI314_RS00330	COG0596	Alpha beta hydrolase
BI314_RS00340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI314_RS00355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BI314_RS00380	COG2205	protein histidine kinase activity
BI314_RS00385	COG0028	Belongs to the TPP enzyme family
BI314_RS00400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BI314_RS00405	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BI314_RS00410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI314_RS00445	COG0183	Belongs to the thiolase family
BI314_RS00455	COG0346	lactoylglutathione lyase activity
BI314_RS00465	COG2032	superoxide dismutase activity
BI314_RS00470	COG2032	superoxide dismutase activity
BI314_RS00475	COG2204	response regulator
BI314_RS00480	COG3852	Histidine kinase
BI314_RS00485	COG0004	ammonium transporteR
BI314_RS00490	COG0347	Belongs to the P(II) protein family
BI314_RS00495	COG0174	glutamine synthetase
BI314_RS00505	COG1968	undecaprenyl-diphosphatase activity
BI314_RS00550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI314_RS00560	COG2062	phosphohistidine phosphatase, SixA
BI314_RS00565	COG0489	protein tyrosine kinase activity
BI314_RS00590	COG1396	sequence-specific DNA binding
BI314_RS00610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI314_RS00625	COG1125	glycine betaine transport
BI314_RS00640	COG1119	ATPase activity
BI314_RS00650	COG1752	Esterase of the alpha-beta hydrolase superfamily
BI314_RS00660	COG1522	sequence-specific DNA binding
BI314_RS00665	COG3186	Phenylalanine-4-hydroxylase
BI314_RS00680	COG2755	lipolytic protein G-D-S-L family
BI314_RS00690	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS00695	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BI314_RS00705	COG1609	Transcriptional regulator
BI314_RS00710	COG3507	Belongs to the glycosyl hydrolase 43 family
BI314_RS00725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI314_RS00735	COG2755	lipolytic protein G-D-S-L family
BI314_RS00735	COG0657	acetylesterase activity
BI314_RS00760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI314_RS00765	COG0366	Alpha amylase catalytic
BI314_RS00770	COG0366	Alpha amylase catalytic
BI314_RS00855	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BI314_RS00860	COG3710	Transcriptional regulator
BI314_RS00880	COG2197	response regulator
BI314_RS00885	COG4585	Histidine kinase
BI314_RS00900	COG1304	FMN binding
BI314_RS00925	COG1012	belongs to the aldehyde dehydrogenase family
BI314_RS00930	COG0662	Cupin 2, conserved barrel domain protein
BI314_RS00940	COG4772	TonB-dependent receptor
BI314_RS00950	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BI314_RS00980	COG0714	Associated with various cellular activities
BI314_RS01020	COG0477	Major facilitator Superfamily
BI314_RS01030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI314_RS01080	COG3237	CsbD-like
BI314_RS01160	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI314_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS01190	COG0300	oxidoreductase activity
BI314_RS01210	COG1272	protein, Hemolysin III
BI314_RS01215	COG1205	dead DEAH box helicase
BI314_RS01215	COG1111	helicase
BI314_RS01310	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BI314_RS01340	COG1132	(ABC) transporter
BI314_RS01370	COG0367	asparagine synthase
BI314_RS01390	COG0438	transferase activity, transferring glycosyl groups
BI314_RS01390	COG0297	glycogen (starch) synthase activity
BI314_RS01395	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BI314_RS01410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BI314_RS01460	COG0069	glutamate synthase activity
BI314_RS01460	COG0067	glutamate synthase
BI314_RS01460	COG0070	glutamate synthase
BI314_RS01465	COG0493	'glutamate synthase
BI314_RS01475	COG1064	alcohol dehydrogenase
BI314_RS01485	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI314_RS01490	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI314_RS01500	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI314_RS01510	COG2234	aminopeptidase activity
BI314_RS01520	COG4942	peptidase
BI314_RS01525	COG0793	Belongs to the peptidase S41A family
BI314_RS01570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI314_RS01580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BI314_RS01610	COG0501	Belongs to the peptidase M48B family
BI314_RS01620	COG0187	DNA topoisomerase II activity
BI314_RS01625	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BI314_RS01635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BI314_RS01650	COG0594	ribonuclease P activity
BI314_RS01655	COG0706	membrane insertase activity
BI314_RS01660	COG0726	polysaccharide deacetylase
BI314_RS01665	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BI314_RS01680	COG0584	glycerophosphoryl diester phosphodiesterase
BI314_RS01695	COG0861	Integral membrane protein TerC family
BI314_RS01705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BI314_RS01720	COG2271	Major facilitator Superfamily
BI314_RS01725	COG1929	Belongs to the glycerate kinase type-1 family
BI314_RS01730	COG3835	regulator
BI314_RS01735	COG3706	GGDEF domain
BI314_RS01750	COG3537	Alpha-1,2-mannosidase
BI314_RS01755	COG0531	amino acid
BI314_RS01765	COG0625	glutathione transferase activity
BI314_RS01785	COG0604	alcohol dehydrogenase
BI314_RS01790	COG1322	Protein conserved in bacteria
BI314_RS01800	COG0386	Belongs to the glutathione peroxidase family
BI314_RS01810	COG2853	Lipoprotein
BI314_RS01825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI314_RS01830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI314_RS01835	COG1127	ABC transporter
BI314_RS01850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BI314_RS01855	COG1074	ATP-dependent DNA helicase activity
BI314_RS01860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BI314_RS01895	COG0439	Biotin carboxylase
BI314_RS01945	COG0564	pseudouridine synthase activity
BI314_RS01970	COG1487	ribonuclease activity
BI314_RS01975	COG4691	Plasmid stability protein
BI314_RS01995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI314_RS02005	COG0477	Major facilitator Superfamily
BI314_RS02010	COG1289	transmembrane transporter activity
BI314_RS02020	COG1566	PFAM secretion protein HlyD family protein
BI314_RS02035	COG0302	gtp cyclohydrolase
BI314_RS02055	COG0730	response to heat
BI314_RS02060	COG3012	SEC-C Motif Domain Protein
BI314_RS02070	COG0676	glucose-6-phosphate 1-epimerase activity
BI314_RS02090	COG3135	benzoate transporter
BI314_RS02125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BI314_RS02135	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BI314_RS02145	COG1435	thymidine kinase activity
BI314_RS02150	COG0210	DNA helicase
BI314_RS02165	COG3132	Protein of unknown function, DUF480
BI314_RS02175	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BI314_RS02180	COG0284	orotidine-5'-phosphate decarboxylase activity
BI314_RS02210	COG2937	Belongs to the GPAT DAPAT family
BI314_RS02275	COG2211	Major facilitator Superfamily
BI314_RS02290	COG3693	PFAM glycoside hydrolase, family 10
BI314_RS02305	COG1904	glucuronate isomerase
BI314_RS02310	COG3250	beta-galactosidase activity
BI314_RS02320	COG3386	PFAM SMP-30 Gluconolaconase
BI314_RS02395	COG0246	Mannitol dehydrogenase
BI314_RS02400	COG1472	Belongs to the glycosyl hydrolase 3 family
BI314_RS02410	COG4948	Mandelate Racemase Muconate Lactonizing
BI314_RS02420	COG3661	Belongs to the glycosyl hydrolase 67 family
BI314_RS02430	COG2115	Belongs to the xylose isomerase family
BI314_RS02440	COG0037	tRNA processing
BI314_RS02445	COG2974	May be involved in recombination
BI314_RS02470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BI314_RS02480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI314_RS02485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI314_RS02490	COG0805	protein transport
BI314_RS02500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI314_RS02500	COG0519	Catalyzes the synthesis of GMP from XMP
BI314_RS02515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI314_RS02520	COG0752	glycyl-tRNA synthetase alpha subunit
BI314_RS02555	COG0729	surface antigen
BI314_RS02560	COG2911	Protein conserved in bacteria
BI314_RS02580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI314_RS02590	COG3265	gluconokinase activity
BI314_RS02595	COG2211	Major facilitator Superfamily
BI314_RS02600	COG3459	Glycosyltransferase 36 associated
BI314_RS02615	COG2205	protein histidine kinase activity
BI314_RS02620	COG1971	Probably functions as a manganese efflux pump
BI314_RS02625	COG1414	Transcriptional regulator
BI314_RS02630	COG0738	Major facilitator superfamily
BI314_RS02635	COG3254	rhamnose metabolic process
BI314_RS02645	COG4948	Mandelate Racemase Muconate Lactonizing
BI314_RS02655	COG0179	Fumarylacetoacetate (FAA) hydrolase
BI314_RS02660	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS02680	COG3507	Belongs to the glycosyl hydrolase 43 family
BI314_RS02710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI314_RS02720	COG3162	membrane
BI314_RS02725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI314_RS02735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI314_RS02745	COG1940	carbohydrate kinase activity
BI314_RS02745	COG1846	Transcriptional regulator
BI314_RS02750	COG0708	Exodeoxyribonuclease III
BI314_RS02765	COG2091	lysine biosynthetic process via aminoadipic acid
BI314_RS02775	COG3540	Alkaline phosphatase
BI314_RS02780	COG0357	Ribosomal RNA small subunit methyltransferase G
BI314_RS02800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI314_RS02820	COG2159	amidohydrolase
BI314_RS02835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI314_RS02840	COG0583	DNA-binding transcription factor activity
BI314_RS02845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI314_RS02860	COG0210	DNA helicase
BI314_RS03030	COG0631	protein serine/threonine phosphatase activity
BI314_RS03035	COG2815	serine threonine protein kinase
BI314_RS03035	COG0515	serine threonine protein kinase
BI314_RS03075	COG0408	coproporphyrinogen oxidase activity
BI314_RS03095	COG0823	Involved in the tonB-independent uptake of proteins
BI314_RS03095	COG1506	peptidase
BI314_RS03095	COG4946	Tricorn protease homolog
BI314_RS03125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI314_RS03140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI314_RS03180	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS03200	COG0463	Glycosyl transferase, family 2
BI314_RS03210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BI314_RS03215	COG3100	YcgL domain-containing protein
BI314_RS03230	COG3387	PFAM Glycoside hydrolase 15-related
BI314_RS03235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI314_RS03255	COG2239	Acts as a magnesium transporter
BI314_RS03260	COG0045	succinate-CoA ligase (ADP-forming) activity
BI314_RS03260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI314_RS03260	COG1042	CoA-binding domain protein
BI314_RS03275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI314_RS03285	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI314_RS03320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BI314_RS03330	COG0842	Transport permease protein
BI314_RS03335	COG1131	(ABC) transporter
BI314_RS03340	COG0543	2 iron, 2 sulfur cluster binding
BI314_RS03340	COG0633	Ferredoxin
BI314_RS03385	COG1476	TRANSCRIPTIONal
BI314_RS03395	COG4555	ABC transporter
BI314_RS03435	COG0625	glutathione transferase activity
BI314_RS03500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BI314_RS03515	COG1199	ATP-dependent helicase activity
BI314_RS03555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI314_RS03605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BI314_RS03620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BI314_RS03665	COG3237	CsbD-like
BI314_RS03670	COG0180	Tryptophanyl-tRNA synthetase
BI314_RS03675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI314_RS03695	COG0697	spore germination
BI314_RS03720	COG1136	(ABC) transporter
BI314_RS03725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI314_RS03730	COG4585	Histidine kinase
BI314_RS03735	COG2197	response regulator
BI314_RS03750	COG0753	catalase activity
BI314_RS03765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI314_RS03770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI314_RS03795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI314_RS03825	COG0642	Histidine kinase
BI314_RS03835	COG1090	epimerase
BI314_RS03870	COG1690	Belongs to the RtcB family
BI314_RS03910	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BI314_RS03925	COG0606	chelatase, subunit chli
BI314_RS03965	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BI314_RS03970	COG1166	arginine decarboxylase activity
BI314_RS03975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI314_RS03985	COG2755	lipolytic protein G-D-S-L family
BI314_RS03985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI314_RS03990	COG4221	oxidoreductase activity
BI314_RS04005	COG0018	arginyl-trna synthetase
BI314_RS04010	COG2003	Belongs to the UPF0758 family
BI314_RS04015	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BI314_RS04020	COG0756	dUTP diphosphatase activity
BI314_RS04040	COG0463	Glycosyl transferase, family 2
BI314_RS04060	COG1475	DNA binding
BI314_RS04065	COG1192	Involved in chromosome partitioning
BI314_RS04075	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BI314_RS04080	COG0708	Exodeoxyribonuclease III
BI314_RS04085	COG2211	Major facilitator Superfamily
BI314_RS04095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BI314_RS04100	COG0739	heme binding
BI314_RS04105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BI314_RS04150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BI314_RS04165	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BI314_RS04195	COG0109	protoheme IX farnesyltransferase activity
BI314_RS04210	COG0358	DNA primase activity
BI314_RS04215	COG1295	ribonuclease BN
BI314_RS04225	COG1610	YqeY-like protein
BI314_RS04235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BI314_RS04240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BI314_RS04250	COG2133	pyrroloquinoline quinone binding
BI314_RS04255	COG4682	membrane
BI314_RS04270	COG0531	amino acid
BI314_RS04280	COG4948	Mandelate Racemase Muconate Lactonizing
BI314_RS04290	COG3023	N-Acetylmuramoyl-L-alanine amidase
BI314_RS04295	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BI314_RS04340	COG5383	Protein conserved in bacteria
BI314_RS04350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI314_RS04355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI314_RS04360	COG1473	amidohydrolase
BI314_RS04365	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI314_RS04365	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI314_RS04370	COG1652	LysM domain
BI314_RS04380	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BI314_RS04385	COG1518	maintenance of DNA repeat elements
BI314_RS04430	COG0583	DNA-binding transcription factor activity
BI314_RS04435	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BI314_RS04440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BI314_RS04445	COG3118	belongs to the thioredoxin family
BI314_RS04450	COG0513	Belongs to the DEAD box helicase family
BI314_RS04455	COG2884	Cell division ATP-binding protein ftsE
BI314_RS04460	COG2177	Part of the ABC transporter FtsEX involved in
BI314_RS04465	COG3437	response regulator, receiver
BI314_RS04470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BI314_RS04475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI314_RS04480	COG2860	membrane
BI314_RS04485	COG1252	NADH dehydrogenase
BI314_RS04500	COG0625	glutathione transferase activity
BI314_RS04505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BI314_RS04525	COG0534	Mate efflux family protein
BI314_RS04530	COG0616	signal peptide processing
BI314_RS04540	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS04555	COG0009	L-threonylcarbamoyladenylate synthase
BI314_RS04560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI314_RS04560	COG1754	DNA topoisomerase type I activity
BI314_RS04575	COG2922	Belongs to the Smg family
BI314_RS04580	COG0758	DNA mediated transformation
BI314_RS04585	COG1652	LysM domain
BI314_RS04590	COG0242	peptide deformylase activity
BI314_RS04595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BI314_RS04600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BI314_RS04600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI314_RS04655	COG1560	Kdo2-lipid A biosynthetic process
BI314_RS04660	COG1490	D-aminoacyl-tRNA deacylase activity
BI314_RS04665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI314_RS04700	COG0024	Methionine aminopeptidase
BI314_RS04745	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI314_RS04765	COG0840	transmembrane signaling receptor activity
BI314_RS04800	COG0251	oxidation-reduction process
BI314_RS04875	COG1063	alcohol dehydrogenase
BI314_RS04890	COG1132	(ABC) transporter
BI314_RS04910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BI314_RS04915	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS04930	COG1294	oxidase, subunit
BI314_RS04935	COG1271	oxidase subunit
BI314_RS04985	COG3546	catalase activity
BI314_RS04990	COG3685	Protein conserved in bacteria
BI314_RS05015	COG2972	Histidine kinase
BI314_RS05030	COG0531	amino acid
BI314_RS05065	COG0667	Aldo Keto reductase
BI314_RS05075	COG0583	DNA-binding transcription factor activity
BI314_RS05085	COG3384	dioxygenase
BI314_RS05095	COG1573	uracil-dna glycosylase
BI314_RS05100	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BI314_RS05110	COG0025	NhaP-type Na H and K H
BI314_RS05115	COG1131	(ABC) transporter
BI314_RS05120	COG0842	Transport permease protein
BI314_RS05180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI314_RS05185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BI314_RS05205	COG2202	Pas domain
BI314_RS05205	COG2205	protein histidine kinase activity
BI314_RS05225	COG2813	Specifically methylates the guanine in position
BI314_RS05230	COG1187	pseudouridine synthase activity
BI314_RS05235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI314_RS05255	COG2198	Histidine kinase
BI314_RS05255	COG5002	protein histidine kinase activity
BI314_RS05255	COG0784	Response regulator, receiver
BI314_RS05265	COG1666	GTP binding
BI314_RS05270	COG0697	spore germination
BI314_RS05275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI314_RS05280	COG2011	ABC-type metal ion transport system permease component
BI314_RS05320	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI314_RS05330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI314_RS05350	COG0356	it plays a direct role in the translocation of protons across the membrane
BI314_RS05360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BI314_RS05365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BI314_RS05370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BI314_RS05375	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BI314_RS05380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BI314_RS05385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BI314_RS05400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BI314_RS05405	COG4191	Histidine kinase
BI314_RS05420	COG0577	efflux transmembrane transporter activity
BI314_RS05425	COG0577	efflux transmembrane transporter activity
BI314_RS05425	COG1136	(ABC) transporter
BI314_RS05430	COG1136	(ABC) transporter
BI314_RS05430	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI314_RS05435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI314_RS05440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI314_RS05495	COG0339	signal peptide processing
BI314_RS05510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI314_RS05515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI314_RS05530	COG2819	hydrolase of the alpha beta superfamily
BI314_RS05540	COG1956	GAF domain-containing protein
BI314_RS05545	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BI314_RS05555	COG0720	synthase
BI314_RS05565	COG4206	TonB-dependent receptor
BI314_RS05575	COG0513	Belongs to the DEAD box helicase family
BI314_RS05590	COG0625	glutathione transferase activity
BI314_RS05625	COG0626	cystathionine gamma-synthase activity
BI314_RS05645	COG0438	transferase activity, transferring glycosyl groups
BI314_RS05645	COG1216	Glycosyl transferase, family 2
BI314_RS05675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI314_RS05690	COG0277	FAD linked oxidase domain protein
BI314_RS05695	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BI314_RS05695	COG0546	phosphoglycolate phosphatase activity
BI314_RS05710	COG2086	electron transfer activity
BI314_RS05745	COG0662	Cupin 2, conserved barrel domain protein
BI314_RS05745	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BI314_RS05750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI314_RS05785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI314_RS05785	COG3218	ABC-type transport auxiliary lipoprotein component
BI314_RS05790	COG1127	ABC transporter
BI314_RS05795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI314_RS05810	COG0442	prolyl-tRNA aminoacylation
BI314_RS05820	COG1183	phosphatidylcholine synthase activity
BI314_RS05850	COG0525	valine-tRNA ligase activity
BI314_RS05865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI314_RS05875	COG0795	lipopolysaccharide-transporting ATPase activity
BI314_RS05890	COG4974	Belongs to the 'phage' integrase family
BI314_RS05900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI314_RS05915	COG0047	phosphoribosylformylglycinamidine synthase activity
BI314_RS05915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BI314_RS05925	COG5295	Hep Hag repeat protein
BI314_RS05930	COG1404	Belongs to the peptidase S8 family
BI314_RS05935	COG5295	Hep Hag repeat protein
BI314_RS05940	COG1404	Belongs to the peptidase S8 family
BI314_RS05945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI314_RS05955	COG1459	type II secretion system
BI314_RS05960	COG2165	general secretion pathway protein
BI314_RS05965	COG4970	Tfp pilus assembly protein FimT
BI314_RS05970	COG2165	general secretion pathway protein
BI314_RS05975	COG4795	General secretion pathway protein
BI314_RS05980	COG3156	type II secretion system protein K
BI314_RS05985	COG3166	PFAM Fimbrial assembly family protein
BI314_RS06000	COG1450	Type ii and iii secretion system protein
BI314_RS06010	COG2188	Transcriptional regulator
BI314_RS06065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BI314_RS06080	COG1215	transferase activity, transferring glycosyl groups
BI314_RS06085	COG1215	transferase activity, transferring glycosyl groups
BI314_RS06090	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BI314_RS06095	COG0457	Tetratricopeptide repeat
BI314_RS06125	COG0242	peptide deformylase activity
BI314_RS06130	COG1307	EDD domain protein, DegV family
BI314_RS06175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI314_RS06180	COG0726	polysaccharide deacetylase
BI314_RS06185	COG4773	Receptor
BI314_RS06215	COG1162	GTPase activity
BI314_RS06240	COG2211	Major facilitator Superfamily
BI314_RS06245	COG1609	Transcriptional regulator
BI314_RS06250	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS06255	COG2851	Citrate transporter
BI314_RS06275	COG0642	Histidine kinase
BI314_RS06290	COG2197	response regulator
BI314_RS06305	COG0667	Aldo Keto reductase
BI314_RS06315	COG0583	DNA-binding transcription factor activity
BI314_RS06340	COG1301	dicarboxylic acid transport
BI314_RS06345	COG0280	phosphate acetyltransferase
BI314_RS06345	COG0281	malic enzyme
BI314_RS06370	COG1560	Kdo2-lipid A biosynthetic process
BI314_RS06380	COG1519	Transferase
BI314_RS06385	COG1538	Outer membrane efflux protein
BI314_RS06390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI314_RS06410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BI314_RS06415	COG0066	3-isopropylmalate dehydratase activity
BI314_RS06420	COG0473	3-isopropylmalate dehydrogenase activity
BI314_RS06445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BI314_RS06450	COG0405	Gamma-glutamyltransferase
BI314_RS06455	COG0840	transmembrane signaling receptor activity
BI314_RS06470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BI314_RS06475	COG3710	Transcriptional regulator
BI314_RS06495	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BI314_RS06505	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BI314_RS06520	COG0563	adenylate kinase activity
BI314_RS06525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI314_RS06535	COG3781	membrane
BI314_RS06540	COG0671	phosphoesterase, PA-phosphatase related
BI314_RS06550	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS06560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI314_RS06565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BI314_RS06595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI314_RS06610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BI314_RS06625	COG0352	thiamine-phosphate diphosphorylase activity
BI314_RS06630	COG1773	rubredoxin
BI314_RS06635	COG2912	Transglutaminase-like superfamily
BI314_RS06645	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BI314_RS06655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BI314_RS06675	COG3079	Belongs to the UPF0149 family
BI314_RS06680	COG0006	proline dipeptidase activity
BI314_RS06690	COG0006	proline dipeptidase activity
BI314_RS06705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BI314_RS06710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BI314_RS06720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BI314_RS06725	COG1561	YicC-like family, N-terminal region
BI314_RS06730	COG0194	GDP metabolic process
BI314_RS06740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI314_RS06750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI314_RS06775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BI314_RS06830	COG2304	oxidoreductase activity
BI314_RS06845	COG1301	dicarboxylic acid transport
BI314_RS06850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BI314_RS06855	COG0596	Alpha beta hydrolase
BI314_RS06860	COG4773	Receptor
BI314_RS06870	COG0739	heme binding
BI314_RS06875	COG1376	ErfK ybiS ycfS ynhG family protein
BI314_RS06910	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BI314_RS06915	COG4149	molybdate abc transporter
BI314_RS06920	COG0725	ABC transporter, periplasmic molybdate-binding protein
BI314_RS06925	COG3453	Protein conserved in bacteria
BI314_RS06925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI314_RS06935	COG3047	cAMP biosynthetic process
BI314_RS06940	COG3047	cAMP biosynthetic process
BI314_RS06950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BI314_RS06975	COG0126	phosphoglycerate kinase activity
BI314_RS06985	COG0469	pyruvate kinase activity
BI314_RS07000	COG3588	fructose-bisphosphate aldolase
BI314_RS07005	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BI314_RS07020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI314_RS07020	COG1648	precorrin-2 dehydrogenase activity
BI314_RS07040	COG0784	Response regulator, receiver
BI314_RS07040	COG2205	protein histidine kinase activity
BI314_RS07040	COG2198	Histidine kinase
BI314_RS07060	COG0175	sulfate reduction
BI314_RS07065	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI314_RS07070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI314_RS07075	COG0175	sulfate reduction
BI314_RS07080	COG2895	sulfate adenylyltransferase (ATP) activity
BI314_RS07080	COG0529	Catalyzes the synthesis of activated sulfate
BI314_RS07090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI314_RS07130	COG0308	aminopeptidase N
BI314_RS07140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI314_RS07155	COG4948	Mandelate Racemase Muconate Lactonizing
BI314_RS07160	COG3250	beta-galactosidase activity
BI314_RS07170	COG1609	Transcriptional regulator
BI314_RS07180	COG1970	mechanosensitive ion channel activity
BI314_RS07205	COG3273	potassium ion transport
BI314_RS07205	COG0471	metal ion transport
BI314_RS07210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BI314_RS07220	COG2022	thiamine diphosphate biosynthetic process
BI314_RS07250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BI314_RS07375	COG4191	Histidine kinase
BI314_RS07375	COG0784	Response regulator, receiver
BI314_RS07380	COG0784	Response regulator, receiver
BI314_RS07380	COG4191	Histidine kinase
BI314_RS07405	COG2003	Belongs to the UPF0758 family
BI314_RS07490	COG0745	RESPONSE REGULATOR receiver
BI314_RS07495	COG5002	protein histidine kinase activity
BI314_RS07525	COG0237	dephospho-CoA kinase activity
BI314_RS07530	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BI314_RS07565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI314_RS07580	COG0045	succinate-CoA ligase (ADP-forming) activity
BI314_RS07585	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BI314_RS07610	COG2369	cell adhesion
BI314_RS07640	COG2951	lytic endotransglycosylase activity
BI314_RS07670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BI314_RS07670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI314_RS07680	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI314_RS07685	COG0564	pseudouridine synthase activity
BI314_RS07700	COG3011	Protein conserved in bacteria
BI314_RS07705	COG0840	transmembrane signaling receptor activity
BI314_RS07725	COG3387	PFAM Glycoside hydrolase 15-related
BI314_RS07730	COG1877	trehalose-phosphatase activity
BI314_RS07770	COG2827	Endonuclease containing a URI domain
BI314_RS07775	COG4771	TonB-dependent receptor
BI314_RS07780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI314_RS07785	COG0667	Aldo Keto reductase
BI314_RS07790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI314_RS07795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI314_RS07800	COG1116	anion transmembrane transporter activity
BI314_RS07805	COG0542	response to heat
BI314_RS07810	COG4206	TonB-dependent receptor
BI314_RS07830	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI314_RS07840	COG1492	cobalamin metabolic process
BI314_RS07850	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BI314_RS07875	COG0019	diaminopimelate decarboxylase activity
BI314_RS07890	COG4264	IucA IucC family
BI314_RS07900	COG4772	TonB-dependent receptor
BI314_RS07925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI314_RS07925	COG4651	solute:proton antiporter activity
BI314_RS07965	COG0488	(ABC) transporter
BI314_RS08010	COG0477	Major facilitator Superfamily
BI314_RS08025	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BI314_RS08040	COG0217	transcriptional regulatory protein
BI314_RS08045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BI314_RS08050	COG0632	four-way junction helicase activity
BI314_RS08055	COG3158	transport of potassium into the cell
BI314_RS08065	COG2255	four-way junction helicase activity
BI314_RS08070	COG0824	Thioesterase
BI314_RS08080	COG0848	biopolymer transport protein
BI314_RS08090	COG0823	Involved in the tonB-independent uptake of proteins
BI314_RS08095	COG2885	chlorophyll binding
BI314_RS08105	COG0602	queuosine metabolic process
BI314_RS08115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BI314_RS08120	COG3920	Histidine kinase
BI314_RS08140	COG0840	transmembrane signaling receptor activity
BI314_RS08175	COG0514	ATP-dependent DNA helicase (RecQ)
BI314_RS08185	COG0783	Belongs to the Dps family
BI314_RS08190	COG1643	Atp-dependent helicase
BI314_RS08205	COG0837	glucose binding
BI314_RS08225	COG0535	radical SAM domain protein
BI314_RS08230	COG0535	radical SAM domain protein
BI314_RS08235	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BI314_RS08240	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BI314_RS08250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI314_RS08270	COG1215	transferase activity, transferring glycosyl groups
BI314_RS08275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI314_RS08285	COG1199	ATP-dependent helicase activity
BI314_RS08295	COG1397	ADP-ribosylglycohydrolase
BI314_RS08305	COG0189	ligase activity
BI314_RS08320	COG0835	chemotaxis
BI314_RS08325	COG0840	transmembrane signaling receptor activity
BI314_RS08330	COG0643	Histidine kinase
BI314_RS08330	COG0784	Response regulator, receiver
BI314_RS08330	COG2198	Histidine kinase
BI314_RS08365	COG1446	asparaginase
BI314_RS08370	COG3142	Participates in the control of copper homeostasis
BI314_RS08410	COG3537	Alpha-1,2-mannosidase
BI314_RS08420	COG1486	melibiose metabolic process
BI314_RS08430	COG0531	amino acid
BI314_RS08445	COG1472	Belongs to the glycosyl hydrolase 3 family
BI314_RS08460	COG1388	LysM domain
BI314_RS08460	COG3858	chitin binding
BI314_RS08475	COG0837	glucose binding
BI314_RS08480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BI314_RS08490	COG0494	nUDIX hydrolase
BI314_RS08500	COG3956	TIGRFAM MazG family protein
BI314_RS08505	COG1742	UPF0060 membrane protein
BI314_RS08510	COG0330	HflC and HflK could
BI314_RS08520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BI314_RS08525	COG0509	glycine decarboxylation via glycine cleavage system
BI314_RS08550	COG1960	acyl-CoA dehydrogenase activity
BI314_RS08560	COG1309	transcriptional regulator
BI314_RS08570	COG4771	TonB-dependent receptor
BI314_RS08580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BI314_RS08585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI314_RS08590	COG0463	Glycosyl transferase, family 2
BI314_RS08595	COG0517	IMP dehydrogenase activity
BI314_RS08595	COG0516	GMP reductase activity
BI314_RS08600	COG2982	Protein involved in outer membrane biogenesis
BI314_RS08605	COG1272	protein, Hemolysin III
BI314_RS08610	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BI314_RS08615	COG0739	heme binding
BI314_RS08620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI314_RS08625	COG0626	cystathionine gamma-synthase activity
BI314_RS08630	COG0460	homoserine dehydrogenase
BI314_RS08630	COG0527	aspartate kinase activity
BI314_RS08645	COG1760	l-serine dehydratase
BI314_RS08665	COG2353	YceI-like domain
BI314_RS08670	COG2205	protein histidine kinase activity
BI314_RS08670	COG0784	Response regulator, receiver
BI314_RS08670	COG2198	Histidine kinase
BI314_RS08695	COG2814	Major facilitator Superfamily
BI314_RS08770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BI314_RS08780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BI314_RS08785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BI314_RS08790	COG0259	pyridoxamine-phosphate oxidase activity
BI314_RS08800	COG1842	Phage shock protein A
BI314_RS08825	COG0754	glutathionylspermidine amidase activity
BI314_RS08835	COG2814	Major facilitator Superfamily
BI314_RS08880	COG1234	tRNA 3'-trailer cleavage
BI314_RS08915	COG0531	amino acid
BI314_RS08920	COG2197	response regulator
BI314_RS08950	COG1113	amino acid transport
BI314_RS08960	COG1271	oxidase subunit
BI314_RS08965	COG1294	oxidase, subunit
BI314_RS08980	COG2239	Acts as a magnesium transporter
BI314_RS08985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI314_RS08990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI314_RS09000	COG1660	Displays ATPase and GTPase activities
BI314_RS09005	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BI314_RS09010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI314_RS09025	COG1137	ATPase activity
BI314_RS09030	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BI314_RS09040	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BI314_RS09050	COG0271	Belongs to the BolA IbaG family
BI314_RS09055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BI314_RS09075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BI314_RS09085	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BI314_RS09095	COG0628	permease
BI314_RS09105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BI314_RS09110	COG3178	'Phosphotransferase
BI314_RS09120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI314_RS09125	COG1555	photosystem II stabilization
BI314_RS09140	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI314_RS09145	COG1477	protein flavinylation
BI314_RS09170	COG3128	pkhd-type hydroxylase
BI314_RS09175	COG4774	siderophore transport
BI314_RS09180	COG2146	nitrite reductase [NAD(P)H] activity
BI314_RS09190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BI314_RS09195	COG0719	Fe-S assembly protein
BI314_RS09200	COG0396	ATPase activity
BI314_RS09205	COG0719	Fe-S assembly protein
BI314_RS09210	COG1959	2 iron, 2 sulfur cluster binding
BI314_RS09220	COG0693	protein deglycase activity
BI314_RS09240	COG0739	heme binding
BI314_RS09255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BI314_RS09270	COG5297	Belongs to the glycosyl hydrolase family 6
BI314_RS09280	COG0519	Catalyzes the synthesis of GMP from XMP
BI314_RS09290	COG1678	Uncharacterized ACR, COG1678
BI314_RS09295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BI314_RS09300	COG0540	Belongs to the ATCase OTCase family
BI314_RS09305	COG1764	response to oxidative stress
BI314_RS09315	COG0384	phenazine biosynthesis protein PhzF
BI314_RS09320	COG0384	phenazine biosynthesis protein PhzF
BI314_RS09325	COG0527	aspartate kinase activity
BI314_RS09340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BI314_RS09355	COG0142	geranyltranstransferase activity
BI314_RS09360	COG0629	single-stranded DNA binding
BI314_RS09365	COG5001	Diguanylate cyclase
BI314_RS09365	COG4251	negative regulation of phosphorylation
BI314_RS09365	COG3706	GGDEF domain
BI314_RS09365	COG2203	Gaf domain
BI314_RS09375	COG2080	2 iron, 2 sulfur cluster binding
BI314_RS09380	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI314_RS09385	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI314_RS09430	COG2879	small protein
BI314_RS09435	COG1966	Carbon starvation protein
BI314_RS09440	COG1741	Belongs to the pirin family
BI314_RS09455	COG1741	Belongs to the pirin family
BI314_RS09465	COG1515	deoxyribonuclease V activity
BI314_RS09470	COG0588	phosphoglycerate mutase activity
BI314_RS09480	COG3590	peptidase
BI314_RS09485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI314_RS09490	COG2201	protein-glutamate methylesterase activity
BI314_RS09495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI314_RS09500	COG2202	Pas domain
BI314_RS09500	COG2199	diguanylate cyclase activity
BI314_RS09500	COG2200	EAL domain
BI314_RS09505	COG0835	chemotaxis
BI314_RS09510	COG0840	transmembrane signaling receptor activity
BI314_RS09520	COG2198	Histidine kinase
BI314_RS09520	COG0643	Histidine kinase
BI314_RS09555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BI314_RS09565	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BI314_RS09570	COG0745	RESPONSE REGULATOR receiver
BI314_RS09575	COG2205	protein histidine kinase activity
BI314_RS09585	COG4452	Inner membrane protein CreD
BI314_RS09610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI314_RS09615	COG0735	belongs to the Fur family
BI314_RS09640	COG1309	transcriptional regulator
BI314_RS09650	COG2207	Transcriptional regulator
BI314_RS09660	COG0583	DNA-binding transcription factor activity
BI314_RS09665	COG2814	Major facilitator Superfamily
BI314_RS09675	COG0667	Aldo Keto reductase
BI314_RS09795	COG5002	protein histidine kinase activity
BI314_RS09795	COG5001	Diguanylate cyclase
BI314_RS09800	COG1187	pseudouridine synthase activity
BI314_RS09825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI314_RS09835	COG0475	glutathione-regulated potassium exporter activity
BI314_RS09840	COG5000	phosphorelay sensor kinase activity
BI314_RS09840	COG5002	protein histidine kinase activity
BI314_RS09845	COG0745	RESPONSE REGULATOR receiver
BI314_RS09850	COG1538	Outer membrane efflux protein
BI314_RS09880	COG1132	(ABC) transporter
BI314_RS09925	COG2155	Conserved Protein
BI314_RS09955	COG3118	belongs to the thioredoxin family
BI314_RS09965	COG0495	leucyl-tRNA aminoacylation
BI314_RS09980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BI314_RS09995	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BI314_RS10010	COG2968	Membrane
BI314_RS10015	COG0424	maF-like protein
BI314_RS10025	COG3164	Protein of unknown function
BI314_RS10035	COG0312	modulator of DNA gyrase
BI314_RS10040	COG3028	Belongs to the UPF0307 family
BI314_RS10045	COG0312	modulator of DNA gyrase
BI314_RS10055	COG4104	PAAR repeat-containing protein
BI314_RS10060	COG0142	geranyltranstransferase activity
BI314_RS10065	COG1722	exodeoxyribonuclease VII activity
BI314_RS10070	COG0037	tRNA processing
BI314_RS10080	COG1785	Belongs to the alkaline phosphatase family
BI314_RS10085	COG1301	dicarboxylic acid transport
BI314_RS10090	COG4106	trans-aconitate 2-methyltransferase activity
BI314_RS10100	COG0791	NLP P60 protein
BI314_RS10105	COG0791	NLP P60 protein
BI314_RS10110	COG1047	Peptidyl-prolyl cis-trans
BI314_RS10115	COG2311	Membrane
BI314_RS10120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI314_RS10125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI314_RS10145	COG3590	peptidase
BI314_RS10155	COG3590	peptidase
BI314_RS10175	COG0489	protein tyrosine kinase activity
BI314_RS10185	COG0717	Belongs to the dCTP deaminase family
BI314_RS10210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI314_RS10215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI314_RS10235	COG0494	nUDIX hydrolase
BI314_RS10240	COG0433	COG0433 Predicted ATPase
BI314_RS10255	COG0688	phosphatidylethanolamine metabolic process
BI314_RS10265	COG2890	protein-(glutamine-N5) methyltransferase activity
BI314_RS10270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BI314_RS10275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI314_RS10280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BI314_RS10300	COG0101	tRNA pseudouridine synthase activity
BI314_RS10305	COG0135	phosphoribosylanthranilate isomerase activity
BI314_RS10315	COG0133	tryptophan synthase activity
BI314_RS10325	COG0159	tryptophan synthase activity
BI314_RS10330	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BI314_RS10335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI314_RS10365	COG0300	oxidoreductase activity
BI314_RS10370	COG0149	triose-phosphate isomerase activity
BI314_RS10385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI314_RS10390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI314_RS10395	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI314_RS10400	COG0649	NAD binding
BI314_RS10405	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BI314_RS10410	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BI314_RS10420	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BI314_RS10425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI314_RS10450	COG1007	ATP synthesis coupled electron transport
BI314_RS10460	COG0779	Required for maturation of 30S ribosomal subunits
BI314_RS10465	COG0195	Participates in both transcription termination and antitermination
BI314_RS10470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BI314_RS10475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BI314_RS10480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BI314_RS10485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BI314_RS10490	COG1185	polyribonucleotide nucleotidyltransferase activity
BI314_RS10525	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI314_RS10535	COG2095	MarC family integral membrane protein
BI314_RS10550	COG1611	Belongs to the LOG family
BI314_RS10555	COG3275	phosphorelay sensor kinase activity
BI314_RS10655	COG3179	chitinase
BI314_RS10700	COG4695	Portal protein
BI314_RS10815	COG0556	nucleotide-excision repair
BI314_RS10830	COG3505	Type IV secretory pathway VirD4
BI314_RS10850	COG2948	multi-organism process
BI314_RS10870	COG3702	type iv secretory pathway
BI314_RS10935	COG0366	Alpha amylase catalytic
BI314_RS10965	COG1082	Xylose isomerase domain protein TIM barrel
BI314_RS10990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BI314_RS10995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BI314_RS11010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BI314_RS11015	COG0072	phenylalanine-tRNA ligase activity
BI314_RS11015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI314_RS11065	COG0438	transferase activity, transferring glycosyl groups
BI314_RS11070	COG0438	transferase activity, transferring glycosyl groups
BI314_RS11080	COG0438	transferase activity, transferring glycosyl groups
BI314_RS11105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI314_RS11110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI314_RS11115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI314_RS11135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BI314_RS11145	COG1960	acyl-CoA dehydrogenase activity
BI314_RS11160	COG3040	lipid binding
BI314_RS11175	COG0322	excinuclease ABC activity
BI314_RS11190	COG0784	Response regulator, receiver
BI314_RS11190	COG4191	Histidine kinase
BI314_RS11195	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BI314_RS11200	COG1194	a g-specific adenine glycosylase
BI314_RS11210	COG0552	protein localization to endoplasmic reticulum
BI314_RS11220	COG3938	Belongs to the proline racemase family
BI314_RS11225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI314_RS11240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI314_RS11250	COG0006	proline dipeptidase activity
BI314_RS11265	COG0531	amino acid
BI314_RS11345	COG0326	Molecular chaperone. Has ATPase activity
BI314_RS11350	COG0742	ribosomal rna small subunit methyltransferase
BI314_RS11355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BI314_RS11370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BI314_RS11375	COG0405	Gamma-glutamyltransferase
BI314_RS11380	COG3291	Pkd domain containing protein
BI314_RS11385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BI314_RS11420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BI314_RS11425	COG0343	queuine tRNA-ribosyltransferase activity
BI314_RS11430	COG1862	Preprotein translocase
BI314_RS11440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI314_RS11485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI314_RS11485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI314_RS11490	COG1105	Belongs to the carbohydrate kinase PfkB family
BI314_RS11495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI314_RS11495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI314_RS11500	COG1609	Transcriptional regulator
BI314_RS11505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI314_RS11510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI314_RS11520	COG2902	Dehydrogenase
BI314_RS11530	COG0477	Major facilitator Superfamily
BI314_RS11540	COG5002	protein histidine kinase activity
BI314_RS11540	COG2205	protein histidine kinase activity
BI314_RS11540	COG0784	Response regulator, receiver
BI314_RS11545	COG2733	membrane
BI314_RS11555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BI314_RS11570	COG2223	nitrite transmembrane transporter activity
BI314_RS11575	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BI314_RS11580	COG0243	molybdopterin cofactor binding
BI314_RS11590	COG0477	Major facilitator Superfamily
BI314_RS11595	COG2703	oxygen carrier activity
BI314_RS11605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI314_RS11610	COG0174	glutamine synthetase
BI314_RS11615	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BI314_RS11630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BI314_RS11650	COG3842	ATPase activity
BI314_RS11655	COG1176	ABC-type spermidine putrescine transport system, permease component I
BI314_RS11660	COG1177	transmembrane transport
BI314_RS11665	COG1012	belongs to the aldehyde dehydrogenase family
BI314_RS11680	COG4535	Mg2 and Co2 transporter CorC
BI314_RS11690	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BI314_RS11700	COG1702	phosphate starvation-inducible protein PhoH
BI314_RS11705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI314_RS11720	COG0741	lytic transglycosylase activity
BI314_RS11730	COG0723	plastoquinol--plastocyanin reductase activity
BI314_RS11735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BI314_RS11740	COG2857	Cytochrome c1
BI314_RS11745	COG0625	glutathione transferase activity
BI314_RS11750	COG2969	positive regulation of protein catabolic process
BI314_RS11770	COG1201	RNA secondary structure unwinding
BI314_RS11775	COG2094	Belongs to the DNA glycosylase MPG family
BI314_RS11780	COG0840	transmembrane signaling receptor activity
BI314_RS11785	COG0835	chemotaxis
BI314_RS11970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI314_RS11980	COG1570	exodeoxyribonuclease VII activity
BI314_RS11985	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI314_RS11990	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BI314_RS11990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI314_RS11995	COG0802	atpase or kinase
BI314_RS12000	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI314_RS12005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BI314_RS12030	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS12035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI314_RS12040	COG0501	Belongs to the peptidase M48B family
BI314_RS12050	COG2081	HI0933 family
BI314_RS12055	COG4681	YaeQ
BI314_RS12065	COG0625	glutathione transferase activity
BI314_RS12075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BI314_RS12080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI314_RS12085	COG0513	Belongs to the DEAD box helicase family
BI314_RS12090	COG0488	(ABC) transporter
BI314_RS12115	COG0483	inositol monophosphate 1-phosphatase activity
BI314_RS12130	COG3300	MHYT domain
BI314_RS12130	COG5001	Diguanylate cyclase
BI314_RS12135	COG1509	lysine 2,3-aminomutase activity
BI314_RS12140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI314_RS12150	COG0402	S-adenosylhomocysteine deaminase activity
BI314_RS12155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BI314_RS12185	COG2963	transposase activity
BI314_RS12220	COG4302	ethanolamine ammonia-lyase activity
BI314_RS12250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BI314_RS12255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BI314_RS12270	COG2166	iron-sulfur cluster assembly
BI314_RS12275	COG0215	cysteine-tRNA ligase activity
BI314_RS12285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BI314_RS12290	COG0137	argininosuccinate synthase activity
BI314_RS12300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI314_RS12305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BI314_RS12315	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BI314_RS12320	COG0165	Argininosuccinate lyase
BI314_RS12335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BI314_RS12365	COG1294	oxidase, subunit
BI314_RS12375	COG4988	ABC transporter
BI314_RS12380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BI314_RS12385	COG1278	Cold shock
BI314_RS12390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI314_RS12410	COG1138	Cytochrome C-type biogenesis protein
BI314_RS12415	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BI314_RS12435	COG4133	protoheme IX ABC transporter activity
BI314_RS12440	COG0436	Aminotransferase
BI314_RS12460	COG1187	pseudouridine synthase activity
BI314_RS12465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BI314_RS12470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BI314_RS12475	COG2350	Protein conserved in bacteria
BI314_RS12505	COG1175	transmembrane transport
BI314_RS12510	COG0395	ABC-type sugar transport system, permease component
BI314_RS12535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI314_RS12540	COG2957	Belongs to the agmatine deiminase family
BI314_RS12560	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BI314_RS12565	COG0539	negative regulation of cytoplasmic translation
BI314_RS12570	COG0776	regulation of translation
BI314_RS12580	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BI314_RS12585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI314_RS12595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BI314_RS12600	COG0475	glutathione-regulated potassium exporter activity
BI314_RS12600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI314_RS12610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BI314_RS12620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI314_RS12620	COG0519	Catalyzes the synthesis of GMP from XMP
BI314_RS12625	COG0582	viral genome integration into host DNA
BI314_RS12660	COG2003	Belongs to the UPF0758 family
BI314_RS12680	COG2084	Dehydrogenase
BI314_RS12760	COG0210	DNA helicase
BI314_RS12910	COG2207	Transcriptional regulator
BI314_RS12915	COG2807	transmembrane transport
BI314_RS12930	COG3938	Belongs to the proline racemase family
BI314_RS12940	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI314_RS12955	COG5006	permease, DMT superfamily
BI314_RS12970	COG4804	nuclease activity
BI314_RS13020	COG0270	DNA (cytosine-5-)-methyltransferase activity
BI314_RS13075	COG2274	protein secretion by the type I secretion system
BI314_RS13115	COG4206	TonB-dependent receptor
BI314_RS13140	COG2336	PFAM SpoVT AbrB
BI314_RS13160	COG4774	siderophore transport
BI314_RS13175	COG0582	viral genome integration into host DNA
BI314_RS13200	COG2003	Belongs to the UPF0758 family
BI314_RS13205	COG5489	Protein of unknown function (DUF736)
BI314_RS13210	COG1396	sequence-specific DNA binding
BI314_RS13225	COG3002	Belongs to the UPF0753 family
BI314_RS13230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI314_RS13235	COG0583	DNA-binding transcription factor activity
BI314_RS13250	COG2197	response regulator
BI314_RS13265	COG1335	isochorismatase
BI314_RS13280	COG2814	Major facilitator Superfamily
BI314_RS13295	COG1648	precorrin-2 dehydrogenase activity
BI314_RS13295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI314_RS13320	COG3685	Protein conserved in bacteria
BI314_RS13340	COG5001	Diguanylate cyclase
BI314_RS13350	COG4566	intracellular signal transduction
BI314_RS13400	COG3279	Response regulator of the LytR AlgR family
BI314_RS13435	COG1238	metal cluster binding
BI314_RS13520	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS13530	COG1073	alpha beta
BI314_RS13530	COG2226	methyltransferase
BI314_RS13575	COG0316	Belongs to the HesB IscA family
BI314_RS13575	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BI314_RS13580	COG2154	pterin-4-alpha-carbinolamine dehydratase
BI314_RS13590	COG0428	transporter
BI314_RS13595	COG3064	Membrane
BI314_RS13605	COG1530	ribonuclease E activity
BI314_RS13615	COG1054	Belongs to the UPF0176 family
BI314_RS13635	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BI314_RS13645	COG0582	viral genome integration into host DNA
BI314_RS13685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI314_RS13690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI314_RS13710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BI314_RS13715	COG0322	excinuclease ABC activity
BI314_RS13725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI314_RS13730	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BI314_RS13735	COG1663	tetraacyldisaccharide 4'-kinase activity
BI314_RS13740	COG1132	(ABC) transporter
BI314_RS13750	COG0811	peptide transport
BI314_RS13765	COG1136	(ABC) transporter
BI314_RS13770	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI314_RS13780	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BI314_RS13785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BI314_RS13800	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BI314_RS13825	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI314_RS13830	COG0837	glucose binding
BI314_RS13835	COG0363	glucosamine-6-phosphate deaminase activity
BI314_RS13840	COG0129	dihydroxy-acid dehydratase activity
BI314_RS13845	COG0800	Aldolase
BI314_RS13920	COG0784	Response regulator, receiver
BI314_RS13920	COG2205	protein histidine kinase activity
BI314_RS13925	COG2183	response to ionizing radiation
BI314_RS13935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI314_RS13935	COG0723	plastoquinol--plastocyanin reductase activity
BI314_RS13950	COG3243	poly(R)-hydroxyalkanoic acid synthase
BI314_RS13960	COG1183	phosphatidylcholine synthase activity
BI314_RS13965	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS13980	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BI314_RS13990	COG0668	transmembrane transport
BI314_RS13995	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BI314_RS14010	COG1914	H( )-stimulated, divalent metal cation uptake system
BI314_RS14025	COG0746	molybdenum cofactor guanylyltransferase activity
BI314_RS14030	COG0303	'Molybdopterin
BI314_RS14040	COG0708	Exodeoxyribonuclease III
BI314_RS14080	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI314_RS14085	COG0303	'Molybdopterin
BI314_RS14090	COG1160	GTP binding
BI314_RS14095	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI314_RS14105	COG1426	Protein conserved in bacteria
BI314_RS14115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BI314_RS14130	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI314_RS14130	COG1024	Enoyl-CoA hydratase
BI314_RS14135	COG0183	Belongs to the thiolase family
BI314_RS14145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BI314_RS14150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BI314_RS14160	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BI314_RS14170	COG1674	ftsk spoiiie
BI314_RS14175	COG0492	ferredoxin-NADP+ reductase activity
BI314_RS14185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BI314_RS14195	COG0542	response to heat
BI314_RS14210	COG0482	sulfurtransferase activity
BI314_RS14215	COG2915	High frequency lysogenization protein hflD homolog
BI314_RS14245	COG5002	protein histidine kinase activity
BI314_RS14265	COG0784	Response regulator, receiver
BI314_RS14265	COG0835	chemotaxis
BI314_RS14275	COG1558	bacterial-type flagellum-dependent cell motility
BI314_RS14280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BI314_RS14290	COG4787	bacterial-type flagellum-dependent cell motility
BI314_RS14305	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BI314_RS14310	COG1706	bacterial-type flagellum-dependent cell motility
BI314_RS14315	COG1705	Flagellar rod assembly protein muramidase FlgJ
BI314_RS14315	COG3951	Flagellar rod assembly protein muramidase FlgJ
BI314_RS14325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI314_RS14330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI314_RS14335	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BI314_RS14365	COG2201	protein-glutamate methylesterase activity
BI314_RS14385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI314_RS14390	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS14395	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS14425	COG1677	Flagellar hook-basal body complex protein FliE
BI314_RS14475	COG3190	flagellar
BI314_RS14495	COG1684	flagellar biosynthetic protein fliR
BI314_RS14525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI314_RS14555	COG2198	Histidine kinase
BI314_RS14555	COG0784	Response regulator, receiver
BI314_RS14555	COG0643	Histidine kinase
BI314_RS14575	COG0641	radical SAM
BI314_RS14615	COG3002	Belongs to the UPF0753 family
BI314_RS14690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BI314_RS14695	COG1360	Flagellar Motor Protein
BI314_RS14705	COG0835	chemotaxis
BI314_RS14715	COG0745	RESPONSE REGULATOR receiver
BI314_RS14720	COG2198	Histidine kinase
BI314_RS14720	COG0643	Histidine kinase
BI314_RS14740	COG0840	transmembrane signaling receptor activity
BI314_RS14755	COG0840	transmembrane signaling receptor activity
BI314_RS14760	COG0840	transmembrane signaling receptor activity
BI314_RS14765	COG0840	transmembrane signaling receptor activity
BI314_RS14770	COG0840	transmembrane signaling receptor activity
BI314_RS14780	COG0840	transmembrane signaling receptor activity
BI314_RS14795	COG0840	transmembrane signaling receptor activity
BI314_RS14800	COG0840	transmembrane signaling receptor activity
BI314_RS14815	COG0835	chemotaxis
BI314_RS14825	COG0840	transmembrane signaling receptor activity
BI314_RS14835	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BI314_RS14840	COG2201	protein-glutamate methylesterase activity
BI314_RS14850	COG2267	carboxylic ester hydrolase activity
BI314_RS14880	COG0318	PFAM AMP-dependent synthetase and ligase
BI314_RS14885	COG1024	Enoyl-CoA hydratase
BI314_RS14890	COG2205	protein histidine kinase activity
BI314_RS14890	COG2198	Histidine kinase
BI314_RS14890	COG0784	Response regulator, receiver
BI314_RS14900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BI314_RS14905	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BI314_RS14910	COG3279	Response regulator of the LytR AlgR family
BI314_RS14950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BI314_RS14960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI314_RS14965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BI314_RS14975	COG0505	Belongs to the CarA family
BI314_RS14980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BI314_RS14985	COG2258	MOSC domain
BI314_RS14990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI314_RS15035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI314_RS15055	COG0277	FAD linked oxidase domain protein
BI314_RS15060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI314_RS15070	COG0531	amino acid
BI314_RS15075	COG0531	amino acid
BI314_RS15080	COG0235	Class ii aldolase
BI314_RS15085	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BI314_RS15090	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BI314_RS15105	COG0140	phosphoribosyl-ATP diphosphatase activity
BI314_RS15105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BI314_RS15110	COG0107	imidazoleglycerol-phosphate synthase activity
BI314_RS15115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BI314_RS15120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BI314_RS15125	COG0131	Imidazoleglycerol-phosphate dehydratase
BI314_RS15125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BI314_RS15130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI314_RS15135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BI314_RS15140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BI314_RS15150	COG0124	histidyl-tRNA synthetase
BI314_RS15155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI314_RS15205	COG3210	domain, Protein
BI314_RS15215	COG3210	domain, Protein
BI314_RS15230	COG0726	polysaccharide deacetylase
BI314_RS15230	COG1649	PFAM Uncharacterised BCR, COG1649
BI314_RS15235	COG1215	transferase activity, transferring glycosyl groups
BI314_RS15250	COG1012	belongs to the aldehyde dehydrogenase family
BI314_RS15270	COG0167	dihydroorotate dehydrogenase activity
BI314_RS15275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BI314_RS15280	COG0697	spore germination
BI314_RS15285	COG1794	racemase activity, acting on amino acids and derivatives
BI314_RS15300	COG0671	phosphoesterase, PA-phosphatase related
BI314_RS15305	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BI314_RS15320	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BI314_RS15325	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI314_RS15335	COG5001	Diguanylate cyclase
BI314_RS15335	COG3706	GGDEF domain
BI314_RS15335	COG2203	Gaf domain
BI314_RS15335	COG4251	negative regulation of phosphorylation
BI314_RS15350	COG1472	Belongs to the glycosyl hydrolase 3 family
BI314_RS15375	COG0166	Belongs to the GPI family
BI314_RS15380	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BI314_RS15385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BI314_RS15390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BI314_RS15410	COG1469	GTP cyclohydrolase I activity
BI314_RS15415	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI314_RS15435	COG0477	Major facilitator Superfamily
BI314_RS15440	COG2115	Belongs to the xylose isomerase family
BI314_RS15445	COG1070	Carbohydrate kinase
BI314_RS15455	COG1501	Belongs to the glycosyl hydrolase 31 family
BI314_RS15495	COG0800	Aldolase
BI314_RS15500	COG4948	Mandelate Racemase Muconate Lactonizing
BI314_RS15510	COG3734	2-keto-3-deoxy-galactonokinase
BI314_RS15515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BI314_RS15525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI314_RS15540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BI314_RS15545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BI314_RS15560	COG0352	thiamine-phosphate diphosphorylase activity
BI314_RS15560	COG0351	phosphomethylpyrimidine kinase
BI314_RS15585	COG0583	DNA-binding transcription factor activity
BI314_RS15590	COG1741	Belongs to the pirin family
BI314_RS15610	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BI314_RS15615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BI314_RS15620	COG2137	regulation of response to DNA damage stimulus
BI314_RS15630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BI314_RS15635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI314_RS15645	COG1546	Belongs to the CinA family
BI314_RS15650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BI314_RS15660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI314_RS15665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BI314_RS15675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BI314_RS15680	COG1534	Rna-binding protein
BI314_RS15695	COG1238	metal cluster binding
BI314_RS15700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI314_RS15705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BI314_RS15710	COG2840	Smr protein MutS2
BI314_RS15715	COG0585	pseudouridine synthase activity
BI314_RS15720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BI314_RS15725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BI314_RS15730	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BI314_RS15735	COG0148	phosphopyruvate hydratase activity
BI314_RS15745	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BI314_RS15750	COG0504	CTP synthase activity
BI314_RS15775	COG0306	phosphate transporter
BI314_RS15790	COG1253	flavin adenine dinucleotide binding
BI314_RS15805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI314_RS15810	COG0477	Major facilitator Superfamily
BI314_RS15820	COG1136	(ABC) transporter
BI314_RS15835	COG0438	transferase activity, transferring glycosyl groups
BI314_RS15845	COG2264	protein methyltransferase activity
BI314_RS15880	COG2244	polysaccharide biosynthetic process
BI314_RS15935	COG1595	DNA-templated transcription, initiation
BI314_RS15950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI314_RS15960	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BI314_RS15970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI314_RS15985	COG0784	Response regulator, receiver
BI314_RS15985	COG4191	Histidine kinase
BI314_RS15990	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BI314_RS16025	COG0840	transmembrane signaling receptor activity
BI314_RS16085	COG0583	DNA-binding transcription factor activity
BI314_RS16090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI314_RS16095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BI314_RS16110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BI314_RS16115	COG0077	Prephenate dehydratase
BI314_RS16115	COG1605	Chorismate mutase
BI314_RS16120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BI314_RS16125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BI314_RS16130	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BI314_RS16175	COG1228	amidohydrolase
BI314_RS16180	COG2986	histidine ammonia-lyase
BI314_RS16190	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BI314_RS16205	COG4993	Dehydrogenase
BI314_RS16215	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BI314_RS16230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BI314_RS16235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BI314_RS16240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI314_RS16250	COG3115	cell septum assembly
BI314_RS16260	COG0359	binds to the 23S rRNA
BI314_RS16265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BI314_RS16270	COG0360	Binds together with S18 to 16S ribosomal RNA
BI314_RS16275	COG0316	Belongs to the HesB IscA family
BI314_RS16285	COG0017	Asparaginyl-tRNA synthetase
BI314_RS16305	COG2808	Putative FMN-binding domain
BI314_RS16370	COG0288	reversible hydration of carbon dioxide
BI314_RS16375	COG0662	Cupin 2, conserved barrel domain protein
BI314_RS16385	COG3844	kynureninase activity
BI314_RS16390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI314_RS16400	COG2925	Exonuclease
BI314_RS16425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BI314_RS16430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BI314_RS16430	COG0116	Belongs to the methyltransferase superfamily
BI314_RS16440	COG0488	(ABC) transporter
BI314_RS16475	COG0494	nUDIX hydrolase
BI314_RS16485	COG1024	Enoyl-CoA hydratase
BI314_RS16495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BI314_RS16500	COG0659	secondary active sulfate transmembrane transporter activity
BI314_RS16525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BI314_RS16530	COG0573	inorganic phosphate transmembrane transporter activity
BI314_RS16535	COG0581	inorganic phosphate transmembrane transporter activity
BI314_RS16540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BI314_RS16545	COG0704	Plays a role in the regulation of phosphate uptake
BI314_RS16555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI314_RS16565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI314_RS16575	COG0557	exoribonuclease II activity
BI314_RS16595	COG1960	acyl-CoA dehydrogenase activity
BI314_RS16600	COG1960	acyl-CoA dehydrogenase activity
BI314_RS16605	COG1960	acyl-CoA dehydrogenase activity
BI314_RS16610	COG1960	acyl-CoA dehydrogenase activity
BI314_RS16615	COG2226	methyltransferase
BI314_RS16620	COG1410	methionine synthase
BI314_RS16620	COG0646	methionine synthase
BI314_RS16625	COG1410	methionine synthase
BI314_RS16625	COG0646	methionine synthase
BI314_RS16635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI314_RS16660	COG2900	Belongs to the SlyX family
BI314_RS16675	COG0386	Belongs to the glutathione peroxidase family
BI314_RS16685	COG1725	Transcriptional regulator
BI314_RS16690	COG1131	(ABC) transporter
BI314_RS16720	COG1253	flavin adenine dinucleotide binding
BI314_RS16740	COG2850	peptidyl-arginine hydroxylation
BI314_RS16775	COG1132	(ABC) transporter
BI314_RS16780	COG0583	DNA-binding transcription factor activity
BI314_RS16810	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BI314_RS16820	COG0484	heat shock protein binding
BI314_RS16825	COG0443	Heat shock 70 kDa protein
BI314_RS16830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BI314_RS16835	COG1420	regulation of RNA biosynthetic process
BI314_RS16840	COG0497	DNA recombination
BI314_RS16850	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI314_RS16865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BI314_RS16990	COG3706	GGDEF domain
BI314_RS17035	COG0583	DNA-binding transcription factor activity
BI314_RS17060	COG0415	Belongs to the DNA photolyase family
BI314_RS17065	COG0305	Participates in initiation and elongation during chromosome replication
BI314_RS17075	COG0367	asparagine synthase
BI314_RS17095	COG1960	acyl-CoA dehydrogenase activity
BI314_RS17110	COG0084	hydrolase, TatD family'
BI314_RS17115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BI314_RS17170	COG0386	Belongs to the glutathione peroxidase family
BI314_RS17180	COG0339	signal peptide processing
BI314_RS17230	COG2814	Major facilitator Superfamily
BI314_RS17235	COG1566	PFAM secretion protein HlyD family protein
BI314_RS17265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI314_RS17285	COG4774	siderophore transport
BI314_RS17295	COG0367	asparagine synthase
BI314_RS17300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI314_RS17305	COG1393	Belongs to the ArsC family
BI314_RS17315	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BI314_RS17355	COG0052	Belongs to the universal ribosomal protein uS2 family
BI314_RS17360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BI314_RS17370	COG0528	UMP kinase activity
BI314_RS17375	COG0233	cytoplasmic translational termination
BI314_RS17380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BI314_RS17385	COG0575	Belongs to the CDS family
BI314_RS17390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BI314_RS17395	COG0750	zinc metalloprotease
BI314_RS17410	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI314_RS17415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI314_RS17420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI314_RS17425	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI314_RS17430	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BI314_RS17440	COG0825	malonyl-CoA metabolic process
BI314_RS17455	COG1981	membrane
BI314_RS17475	COG1695	Transcriptional regulator
BI314_RS17495	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI314_RS17505	COG2040	homocysteine
BI314_RS17510	COG0833	amino acid
BI314_RS17515	COG0346	lactoylglutathione lyase activity
BI314_RS17520	COG1131	(ABC) transporter
BI314_RS17535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI314_RS17535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI314_RS17545	COG2878	Part of a membrane complex involved in electron transport
BI314_RS17565	COG1595	DNA-templated transcription, initiation
BI314_RS17590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI314_RS17605	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI314_RS17610	COG0251	oxidation-reduction process
BI314_RS17620	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BI314_RS17620	COG0392	lysyltransferase activity
BI314_RS17655	COG2814	Major facilitator Superfamily
BI314_RS17660	COG1902	pentaerythritol trinitrate reductase activity
BI314_RS17670	COG2824	Alkylphosphonate utilization operon protein PhnA
BI314_RS17680	COG1047	Peptidyl-prolyl cis-trans
BI314_RS17685	COG1077	Cell shape determining protein MreB Mrl
BI314_RS17700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BI314_RS17710	COG5487	UPF0391 membrane protein
BI314_RS17715	COG1451	nucleotide metabolic process
BI314_RS17740	COG0183	Belongs to the thiolase family
BI314_RS17775	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BI314_RS17775	COG1793	dna ligase
BI314_RS17785	COG1793	dna ligase
BI314_RS17790	COG1201	RNA secondary structure unwinding
BI314_RS17800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI314_RS17805	COG1278	Cold shock
BI314_RS17810	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BI314_RS17815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BI314_RS17820	COG1472	Belongs to the glycosyl hydrolase 3 family
BI314_RS17825	COG3046	protein related to deoxyribodipyrimidine photolyase
BI314_RS17830	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BI314_RS17835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BI314_RS17840	COG2954	triphosphatase activity
BI314_RS17845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI314_RS17855	COG1381	Involved in DNA repair and RecF pathway recombination
BI314_RS17860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BI314_RS17865	COG0571	ribonuclease III activity
BI314_RS17880	COG0481	GTPase activity
BI314_RS17885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI314_RS17900	COG1024	Enoyl-CoA hydratase
BI314_RS17900	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI314_RS17920	COG1024	Enoyl-CoA hydratase
BI314_RS17925	COG1960	acyl-CoA dehydrogenase activity
BI314_RS17945	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BI314_RS17950	COG3250	beta-galactosidase activity
BI314_RS17975	COG3209	COG3209 Rhs family protein
BI314_RS17995	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BI314_RS18005	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BI314_RS18025	COG0534	Mate efflux family protein
BI314_RS18030	COG0534	Mate efflux family protein
BI314_RS18035	COG0335	large ribosomal subunit rRNA binding
BI314_RS18040	COG0336	Belongs to the RNA methyltransferase TrmD family
BI314_RS18045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BI314_RS18050	COG0228	four-way junction DNA binding
BI314_RS18055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI314_RS18065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BI314_RS18070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI314_RS18095	COG4191	Histidine kinase
BI314_RS18095	COG0784	Response regulator, receiver
BI314_RS18100	COG3850	Histidine kinase
BI314_RS18100	COG3437	response regulator, receiver
BI314_RS18100	COG2205	protein histidine kinase activity
BI314_RS18100	COG4999	Histidine kinase
BI314_RS18105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI314_RS18115	COG2205	protein histidine kinase activity
BI314_RS18120	COG5507	3-demethylubiquinone-9 3-methyltransferase
BI314_RS18130	COG4771	TonB-dependent receptor
BI314_RS18155	COG2172	sigma factor antagonist activity
BI314_RS18160	COG1366	Belongs to the anti-sigma-factor antagonist family
BI314_RS18165	COG1366	Belongs to the anti-sigma-factor antagonist family
BI314_RS18180	COG0326	Molecular chaperone. Has ATPase activity
BI314_RS18185	COG2207	Transcriptional regulator
BI314_RS18195	COG3152	Membrane
BI314_RS18210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BI314_RS18215	COG1845	cytochrome c oxidase, subunit III
BI314_RS18220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BI314_RS18235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BI314_RS18240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BI314_RS18245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BI314_RS18250	COG0196	riboflavin kinase activity
BI314_RS18260	COG0268	Binds directly to 16S ribosomal RNA
BI314_RS18265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BI314_RS18270	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BI314_RS18275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BI314_RS18280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BI314_RS18285	COG0824	Thioesterase
BI314_RS18300	COG1946	Acyl-CoA thioesterase
BI314_RS18320	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BI314_RS18330	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BI314_RS18360	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BI314_RS18375	COG2197	response regulator
BI314_RS18380	COG4585	Histidine kinase
BI314_RS18395	COG0850	regulation of cytokinetic process
BI314_RS18400	COG2894	cell division
BI314_RS18405	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BI314_RS18415	COG0642	Histidine kinase
BI314_RS18420	COG0745	RESPONSE REGULATOR receiver
BI314_RS18435	COG2194	sulfuric ester hydrolase activity
BI314_RS18450	COG2814	Major facilitator Superfamily
BI314_RS18455	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI314_RS18455	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI314_RS18465	COG0656	L-ascorbic acid biosynthetic process
BI314_RS18470	COG0753	catalase activity
BI314_RS18485	COG1917	Cupin 2, conserved barrel domain protein
BI314_RS18485	COG2207	Transcriptional regulator
BI314_RS18505	COG0823	Involved in the tonB-independent uptake of proteins
BI314_RS18505	COG1506	peptidase
BI314_RS18520	COG1297	OPT oligopeptide transporter protein
BI314_RS18540	COG0587	DNA-directed DNA polymerase activity
BI314_RS18555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI314_RS18590	COG2080	2 iron, 2 sulfur cluster binding
BI314_RS18595	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI314_RS18600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI314_RS18625	COG0492	ferredoxin-NADP+ reductase activity
BI314_RS18645	COG3537	Alpha-1,2-mannosidase
BI314_RS18655	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS18660	COG3387	PFAM Glycoside hydrolase 15-related
BI314_RS18670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI314_RS18705	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BI314_RS18750	COG1309	transcriptional regulator
BI314_RS18755	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS18760	COG0308	aminopeptidase N
BI314_RS18765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BI314_RS18780	COG0330	HflC and HflK could
BI314_RS18785	COG0330	HflC and HflK could
BI314_RS18805	COG0678	peroxiredoxin activity
BI314_RS18815	COG4953	penicillin-binding protein 1C
BI314_RS18835	COG2373	Large extracellular alpha-helical protein
BI314_RS18865	COG3609	addiction module antidote protein, CC2985 family
BI314_RS18885	COG3829	transcription factor binding
BI314_RS18910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BI314_RS18915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BI314_RS18930	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS18945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI314_RS18950	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BI314_RS18955	COG1399	metal-binding, possibly nucleic acid-binding protein
BI314_RS18960	COG0424	maF-like protein
BI314_RS18985	COG0714	Associated with various cellular activities
BI314_RS19005	COG0537	adenosine 5'-monophosphoramidase activity
BI314_RS19010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BI314_RS19015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BI314_RS19070	COG0314	molybdopterin synthase activity
BI314_RS19075	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BI314_RS19080	COG0315	cyclic pyranopterin monophosphate synthase activity
BI314_RS19090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BI314_RS19095	COG1234	tRNA 3'-trailer cleavage
BI314_RS19100	COG3642	lipopolysaccharide core region biosynthetic process
BI314_RS19105	COG0859	PFAM glycosyl transferase family 9
BI314_RS19120	COG0631	protein serine/threonine phosphatase activity
BI314_RS19125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI314_RS19130	COG0328	RNA-DNA hybrid ribonuclease activity
BI314_RS19140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI314_RS19150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI314_RS19175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BI314_RS19185	COG0544	peptidyl-prolyl cis-trans isomerase activity
BI314_RS19345	COG0473	3-isopropylmalate dehydrogenase activity
BI314_RS19360	COG4783	chaperone-mediated protein folding
BI314_RS19375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BI314_RS19385	COG0438	transferase activity, transferring glycosyl groups
BI314_RS19390	COG0671	phosphoesterase, PA-phosphatase related
BI314_RS19395	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI314_RS19405	COG3291	Pkd domain containing protein
BI314_RS19415	COG2833	Protein of unknown function (DUF455)
BI314_RS19435	COG0285	dihydrofolate synthase activity
BI314_RS19440	COG0406	alpha-ribazole phosphatase activity
BI314_RS19470	COG1063	alcohol dehydrogenase
BI314_RS19480	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BI314_RS19485	COG4208	sulfate ABC transporter
BI314_RS19490	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BI314_RS19495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BI314_RS19500	COG0156	8-amino-7-oxononanoate synthase activity
BI314_RS19530	COG0604	alcohol dehydrogenase
BI314_RS19535	COG0446	pyridine nucleotide-disulphide oxidoreductase
BI314_RS19535	COG1902	pentaerythritol trinitrate reductase activity
BI314_RS19550	COG0625	glutathione transferase activity
BI314_RS19555	COG0039	L-malate dehydrogenase activity
BI314_RS19560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BI314_RS19565	COG1217	gtp-binding protein TYPA
BI314_RS19575	COG0154	amidase activity
BI314_RS19585	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BI314_RS19605	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BI314_RS19610	COG0203	ribosomal protein L17
BI314_RS19635	COG0201	protein transport
BI314_RS19640	COG0200	Binds to the 23S rRNA
BI314_RS19645	COG1841	ribosomal large subunit assembly
BI314_RS19655	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BI314_RS19660	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BI314_RS19665	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BI314_RS19675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BI314_RS19680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BI314_RS19690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BI314_RS19695	COG0255	Belongs to the universal ribosomal protein uL29 family
BI314_RS19700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BI314_RS19705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BI314_RS19715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BI314_RS19720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BI314_RS19725	COG0089	rRNA binding
BI314_RS19730	COG0088	Forms part of the polypeptide exit tunnel
BI314_RS19735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BI314_RS19740	COG0051	transcription antitermination factor activity, RNA binding
BI314_RS19745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI314_RS19750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BI314_RS19755	COG0049	tRNA binding
BI314_RS19760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BI314_RS19765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BI314_RS19770	COG0085	RNA polymerase activity
BI314_RS19775	COG0222	ribosome binding
BI314_RS19780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BI314_RS19785	COG0081	regulation of translation
BI314_RS19790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BI314_RS19795	COG0250	Participates in transcription elongation, termination and antitermination
BI314_RS19810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI314_RS19830	COG0012	GTP binding
BI314_RS19835	COG0193	aminoacyl-tRNA hydrolase activity
BI314_RS19840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BI314_RS19845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BI314_RS19855	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BI314_RS19860	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BI314_RS19875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BI314_RS19885	COG0521	Mo-molybdopterin cofactor biosynthetic process
BI314_RS19905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI314_RS19910	COG1295	ribonuclease BN
BI314_RS19935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BI314_RS19940	COG1404	Belongs to the peptidase S8 family
BI314_RS19950	COG1404	Belongs to the peptidase S8 family
BI314_RS19955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI314_RS19970	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BI314_RS19995	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BI314_RS20025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI314_RS20025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI314_RS20045	COG2890	protein-(glutamine-N5) methyltransferase activity
BI314_RS20055	COG3634	alkyl hydroperoxide reductase activity
BI314_RS20060	COG0583	DNA-binding transcription factor activity
BI314_RS20070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI314_RS20075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BI314_RS20085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI314_RS20095	COG2197	response regulator
BI314_RS20100	COG0784	Response regulator, receiver
BI314_RS20100	COG2205	protein histidine kinase activity
BI314_RS20100	COG5002	protein histidine kinase activity
BI314_RS20120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI314_RS20130	COG0697	spore germination
BI314_RS20155	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BI314_RS20170	COG3386	PFAM SMP-30 Gluconolaconase
BI314_RS20190	COG1024	Enoyl-CoA hydratase
BI314_RS20205	COG0583	DNA-binding transcription factor activity
BI314_RS20210	COG3384	dioxygenase
BI314_RS20240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI314_RS20245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI314_RS20260	COG2096	Adenosyltransferase
BI314_RS20265	COG0123	including yeast histone deacetylase and acetoin utilization protein
BI314_RS20280	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BI314_RS20285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI314_RS20290	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BI314_RS20295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BI314_RS20300	COG2967	ApaG domain
BI314_RS20305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BI314_RS20315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI314_RS20325	COG0747	negative chemotaxis
BI314_RS20350	COG0431	NADPH-dependent FMN reductase
BI314_RS20355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI314_RS20365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI314_RS20370	COG1116	anion transmembrane transporter activity
BI314_RS20380	COG3829	transcription factor binding
BI314_RS20395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BI314_RS20400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BI314_RS20420	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BI314_RS20430	COG0642	Histidine kinase
BI314_RS20445	COG4181	ATPase activity
BI314_RS20455	COG2175	clavaminate synthase activity
BI314_RS20465	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BI314_RS20470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI314_RS20490	COG4771	TonB-dependent receptor
BI314_RS20500	COG0667	Aldo Keto reductase
BI314_RS20510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI314_RS20515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI314_RS20525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI314_RS20530	COG4106	trans-aconitate 2-methyltransferase activity
BI314_RS20540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BI314_RS20585	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BI314_RS20600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BI314_RS20605	COG2226	methyltransferase
BI314_RS20640	COG0366	Alpha amylase catalytic
BI314_RS20670	COG3321	synthase
BI314_RS20670	COG0604	alcohol dehydrogenase
BI314_RS20670	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS20685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI314_RS20695	COG0494	nUDIX hydrolase
BI314_RS20700	COG0653	protein targeting
BI314_RS20705	COG0739	heme binding
BI314_RS20715	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BI314_RS20730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BI314_RS20735	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI314_RS20740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI314_RS20745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BI314_RS20755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI314_RS20760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BI314_RS20765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BI314_RS20775	COG3116	cell division
BI314_RS20780	COG0275	rRNA processing
BI314_RS20815	COG0792	nuclease activity
BI314_RS20820	COG1988	membrane-bound metal-dependent
BI314_RS20825	COG0277	FAD linked oxidase domain protein
BI314_RS20840	COG0745	RESPONSE REGULATOR receiver
BI314_RS20845	COG2205	protein histidine kinase activity
BI314_RS20850	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BI314_RS20855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BI314_RS20860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BI314_RS20885	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BI314_RS20890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI314_RS20895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BI314_RS20915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI314_RS20915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI314_RS20925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BI314_RS20930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BI314_RS20940	COG0488	(ABC) transporter
BI314_RS20950	COG0697	spore germination
BI314_RS20960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI314_RS20975	COG3791	Glutathione-dependent formaldehyde-activating
BI314_RS21005	COG2205	protein histidine kinase activity
BI314_RS21025	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BI314_RS21030	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BI314_RS21045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI314_RS21060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI314_RS21065	COG1012	belongs to the aldehyde dehydrogenase family
BI314_RS21070	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BI314_RS21075	COG0617	tRNA 3'-terminal CCA addition
BI314_RS21085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BI314_RS21090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI314_RS21095	COG1609	Transcriptional regulator
BI314_RS21105	COG2188	Transcriptional regulator
BI314_RS21170	COG1459	type II secretion system
BI314_RS21230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BI314_RS21235	COG4191	Histidine kinase
BI314_RS21240	COG0784	Response regulator, receiver
BI314_RS21245	COG4251	negative regulation of phosphorylation
BI314_RS21250	COG2823	Periplasmic or secreted lipoprotein
BI314_RS21255	COG0673	inositol 2-dehydrogenase activity
BI314_RS21260	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BI314_RS21295	COG1056	cytidyltransferase-related domain
BI314_RS21295	COG1051	belongs to the nudix hydrolase family
BI314_RS21305	COG0583	DNA-binding transcription factor activity
BI314_RS21320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BI314_RS21325	COG0321	lipoyl(octanoyl) transferase activity
BI314_RS21330	COG2921	Belongs to the UPF0250 family
BI314_RS21340	COG1686	Belongs to the peptidase S11 family
BI314_RS21350	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BI314_RS21355	COG2951	lytic endotransglycosylase activity
BI314_RS21365	COG0772	Belongs to the SEDS family
BI314_RS21380	COG1792	Involved in formation and maintenance of cell shape
BI314_RS21385	COG1077	Cell shape determining protein MreB Mrl
BI314_RS21390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI314_RS21395	COG3284	Transcriptional regulator
BI314_RS21445	COG0308	aminopeptidase N
BI314_RS21450	COG5001	Diguanylate cyclase
BI314_RS21450	COG3300	MHYT domain
BI314_RS21455	COG2226	methyltransferase
BI314_RS21480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BI314_RS21485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BI314_RS21490	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BI314_RS21500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BI314_RS21510	COG2832	Protein of unknown function (DUF454)
BI314_RS21525	COG0436	Aminotransferase
BI314_RS21530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI314_RS21535	COG1505	serine-type exopeptidase activity
BI314_RS21565	COG0181	hydroxymethylbilane synthase activity
BI314_RS21575	COG3275	phosphorelay sensor kinase activity
BI314_RS21585	COG2943	transferase activity, transferring hexosyl groups
BI314_RS21615	COG0659	secondary active sulfate transmembrane transporter activity
BI314_RS21620	COG5297	Belongs to the glycosyl hydrolase family 6
BI314_RS21620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI314_RS21625	COG0840	transmembrane signaling receptor activity
BI314_RS21680	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
BI314_RS21700	COG1113	amino acid transport
BI314_RS21715	COG0697	spore germination
BI314_RS21755	COG0823	Involved in the tonB-independent uptake of proteins
BI314_RS21755	COG1506	peptidase
BI314_RS21765	COG2409	Drug exporters of the RND superfamily
BI314_RS21790	COG0435	Glutathione S-transferase
BI314_RS21800	COG4221	oxidoreductase activity
BI314_RS21815	COG4221	oxidoreductase activity
BI314_RS21875	COG1802	Transcriptional regulator
BI314_RS21885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BI314_RS21910	COG3052	prosthetic group binding
BI314_RS21940	COG2353	YceI-like domain
BI314_RS21945	COG0778	Nitroreductase
BI314_RS21965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI314_RS21970	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BI314_RS21980	COG3386	PFAM SMP-30 Gluconolaconase
BI314_RS21995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BI314_RS22010	COG0459	protein refolding
BI314_RS22025	COG2356	endonuclease I
BI314_RS22030	COG0300	oxidoreductase activity
BI314_RS22060	COG1324	tolerance protein
BI314_RS22070	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BI314_RS22075	COG0511	ligase activity, forming carbon-carbon bonds
BI314_RS22085	COG0439	Biotin carboxylase
BI314_RS22105	COG2264	protein methyltransferase activity
BI314_RS22125	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BI314_RS22130	COG4589	Belongs to the CDS family
BI314_RS22155	COG0671	phosphoesterase, PA-phosphatase related
BI314_RS22155	COG2453	phosphatase
BI314_RS22160	COG2267	carboxylic ester hydrolase activity
BI314_RS22165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BI314_RS22170	COG0138	bifunctional purine biosynthesis protein purh
BI314_RS22180	COG0151	Belongs to the GarS family
BI314_RS22190	COG1289	transmembrane transporter activity
BI314_RS22195	COG2814	Major facilitator Superfamily
BI314_RS22200	COG0583	DNA-binding transcription factor activity
BI314_RS22205	COG2814	Major facilitator Superfamily
BI314_RS22225	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI314_RS22255	COG0316	Belongs to the HesB IscA family
BI314_RS22295	COG1051	belongs to the nudix hydrolase family
BI314_RS22310	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BI314_RS22320	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BI314_RS22330	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BI314_RS22335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI314_RS22345	COG0134	indole-3-glycerol-phosphate synthase activity
BI314_RS22350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BI314_RS22375	COG1597	lipid kinase activity
BI314_RS22380	COG0456	acetyltransferase
BI314_RS22395	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BI314_RS22400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BI314_RS22420	COG3179	chitinase
BI314_RS22445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI314_RS22445	COG2111	Na H antiporter
BI314_RS22450	COG1006	Multisubunit Na H antiporter MnhC subunit
BI314_RS22455	COG0651	ATP synthesis coupled electron transport
BI314_RS22465	COG2212	antiporter activity
BI314_RS22470	COG1320	monovalent cation:proton antiporter activity
BI314_RS22490	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BI314_RS22515	COG3104	oligopeptide transport
BI314_RS22520	COG3483	tryptophan 2,3-dioxygenase activity
BI314_RS22530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BI314_RS22550	COG0513	Belongs to the DEAD box helicase family
BI314_RS22560	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS22565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI314_RS22600	COG1028	Short-chain dehydrogenase reductase Sdr
BI314_RS22605	COG0702	epimerase
BI314_RS22630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI314_RS22635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI314_RS22640	COG0297	glycogen (starch) synthase activity
BI314_RS22650	COG2354	Protein conserved in bacteria
BI314_RS22655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI314_RS22665	COG1368	sulfuric ester hydrolase activity
BI314_RS22670	COG3264	Mechanosensitive ion channel
BI314_RS22670	COG1511	domain protein
BI314_RS22740	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI314_RS22825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BI314_RS22830	COG1040	competence protein
BI314_RS22835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BI314_RS22840	COG0156	8-amino-7-oxononanoate synthase activity
BI314_RS22850	COG2267	carboxylic ester hydrolase activity
BI314_RS22880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BI314_RS22890	COG0445	tRNA wobble uridine modification
BI314_RS22900	COG0657	acetylesterase activity
BI314_RS22910	COG1414	Transcriptional regulator
BI314_RS22920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BI314_RS22925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI314_RS22935	COG3485	protocatechuate 3,4-dioxygenase
BI314_RS22940	COG3485	protocatechuate 3,4-dioxygenase
BI314_RS22950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BI314_RS22955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BI314_RS22980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BI314_RS22985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BI314_RS23040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BI314_RS23055	COG0129	dihydroxy-acid dehydratase activity
BI314_RS23095	COG1733	regulation of RNA biosynthetic process
BI314_RS23100	COG0702	epimerase
BI314_RS23135	COG0583	DNA-binding transcription factor activity
BI314_RS23140	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI314_RS23145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI314_RS23165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI314_RS23170	COG2205	protein histidine kinase activity
BI314_RS23175	COG0745	RESPONSE REGULATOR receiver
BI314_RS23195	COG1902	pentaerythritol trinitrate reductase activity
BI314_RS23200	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BI314_RS23215	COG2814	Major facilitator Superfamily
BI314_RS23220	COG0583	DNA-binding transcription factor activity
BI314_RS23235	COG0084	hydrolase, TatD family'
BI314_RS23260	COG2252	PERMEase
BI314_RS23305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BI314_RS23325	COG2072	flavoprotein involved in K transport
BI314_RS23330	COG2351	hydroxyisourate hydrolase activity
BI314_RS23650	COG1199	ATP-dependent helicase activity
BI314_RS23660	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BI314_RS23670	COG0745	RESPONSE REGULATOR receiver
BI314_RS23820	COG1475	DNA binding
BI314_RS23855	COG0629	single-stranded DNA binding
BI314_RS23880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI314_RS23975	COG4232	protein-disulfide reductase activity
BI314_RS24065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI314_RS24070	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI314_RS24085	COG0010	Belongs to the arginase family
BI314_RS24140	COG2132	Multicopper oxidase
BI314_RS24170	COG0653	protein targeting
BI314_RS24195	COG3318	Belongs to the UPF0149 family
BI314_RS24195	COG3012	SEC-C Motif Domain Protein
BI314_RS24230	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI314_RS24240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BI314_RS24255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI314_RS24265	COG0431	NADPH-dependent FMN reductase
BI314_RS24270	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BI314_RS24315	COG4644	lycopene metabolic process
BI314_RS24340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI314_RS24560	COG3504	Conjugal transfer protein
BI314_RS24565	COG2948	multi-organism process
BI314_RS24690	COG1192	Involved in chromosome partitioning
BI314_RS24730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI314_RS24840	COG2951	lytic endotransglycosylase activity
BI314_RS24885	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI314_RS24905	COG3318	Belongs to the UPF0149 family
BI314_RS24905	COG3012	SEC-C Motif Domain Protein
BI314_RS24970	COG3318	Belongs to the UPF0149 family
BI314_RS24970	COG3012	SEC-C Motif Domain Protein
BI314_RS25005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI314_RS25010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI314_RS25015	COG4456	Virulence-associated protein
BI314_RS25305	COG1525	nuclease