locus-tag	class	description
B7L65_RS00020	COG0367	asparagine synthase
B7L65_RS00040	COG0297	glycogen (starch) synthase activity
B7L65_RS00040	COG0438	transferase activity, transferring glycosyl groups
B7L65_RS00045	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B7L65_RS00110	COG0070	glutamate synthase
B7L65_RS00110	COG0067	glutamate synthase
B7L65_RS00110	COG0069	glutamate synthase activity
B7L65_RS00115	COG0493	'glutamate synthase
B7L65_RS00120	COG1064	alcohol dehydrogenase
B7L65_RS00130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L65_RS00175	COG2937	Belongs to the GPAT DAPAT family
B7L65_RS00210	COG0284	orotidine-5'-phosphate decarboxylase activity
B7L65_RS00215	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B7L65_RS00240	COG0210	DNA helicase
B7L65_RS00245	COG1435	thymidine kinase activity
B7L65_RS00270	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B7L65_RS00280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B7L65_RS00310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B7L65_RS00315	COG0739	heme binding
B7L65_RS00320	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B7L65_RS00330	COG2211	Major facilitator Superfamily
B7L65_RS00335	COG0708	Exodeoxyribonuclease III
B7L65_RS00340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B7L65_RS00350	COG1192	Involved in chromosome partitioning
B7L65_RS00355	COG1475	DNA binding
B7L65_RS00375	COG0463	Glycosyl transferase, family 2
B7L65_RS00395	COG0756	dUTP diphosphatase activity
B7L65_RS00400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B7L65_RS00405	COG2003	Belongs to the UPF0758 family
B7L65_RS00410	COG0018	arginyl-trna synthetase
B7L65_RS00425	COG4221	oxidoreductase activity
B7L65_RS00430	COG2755	lipolytic protein G-D-S-L family
B7L65_RS00430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B7L65_RS00440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L65_RS00445	COG1166	arginine decarboxylase activity
B7L65_RS00450	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B7L65_RS00490	COG0606	chelatase, subunit chli
B7L65_RS00515	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B7L65_RS00555	COG1690	Belongs to the RtcB family
B7L65_RS00590	COG1090	epimerase
B7L65_RS00600	COG0642	Histidine kinase
B7L65_RS00630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7L65_RS00655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B7L65_RS00660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B7L65_RS00675	COG0753	catalase activity
B7L65_RS00690	COG2197	response regulator
B7L65_RS00695	COG4585	Histidine kinase
B7L65_RS00700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L65_RS00705	COG1136	(ABC) transporter
B7L65_RS00730	COG0697	spore germination
B7L65_RS00750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L65_RS00755	COG0180	Tryptophanyl-tRNA synthetase
B7L65_RS00760	COG3237	CsbD-like
B7L65_RS00805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B7L65_RS00820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B7L65_RS00870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B7L65_RS00900	COG1199	ATP-dependent helicase activity
B7L65_RS00915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B7L65_RS00980	COG0625	glutathione transferase activity
B7L65_RS01020	COG4555	ABC transporter
B7L65_RS01030	COG1476	TRANSCRIPTIONal
B7L65_RS01075	COG0633	Ferredoxin
B7L65_RS01075	COG0543	2 iron, 2 sulfur cluster binding
B7L65_RS01080	COG1131	(ABC) transporter
B7L65_RS01085	COG0842	Transport permease protein
B7L65_RS01095	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B7L65_RS01130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L65_RS01140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L65_RS01160	COG1042	CoA-binding domain protein
B7L65_RS01160	COG0045	succinate-CoA ligase (ADP-forming) activity
B7L65_RS01160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B7L65_RS01165	COG2239	Acts as a magnesium transporter
B7L65_RS01185	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B7L65_RS01190	COG3387	PFAM Glycoside hydrolase 15-related
B7L65_RS01205	COG3100	YcgL domain-containing protein
B7L65_RS01210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B7L65_RS01220	COG0463	Glycosyl transferase, family 2
B7L65_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS01275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L65_RS01290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B7L65_RS01320	COG0823	Involved in the tonB-independent uptake of proteins
B7L65_RS01320	COG1506	peptidase
B7L65_RS01320	COG4946	Tricorn protease homolog
B7L65_RS01340	COG0408	coproporphyrinogen oxidase activity
B7L65_RS01380	COG2815	serine threonine protein kinase
B7L65_RS01380	COG0515	serine threonine protein kinase
B7L65_RS01385	COG0631	protein serine/threonine phosphatase activity
B7L65_RS01555	COG0210	DNA helicase
B7L65_RS01570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L65_RS01575	COG0583	DNA-binding transcription factor activity
B7L65_RS01580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B7L65_RS01595	COG2159	amidohydrolase
B7L65_RS01615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L65_RS01635	COG0357	Ribosomal RNA small subunit methyltransferase G
B7L65_RS01640	COG3540	Alkaline phosphatase
B7L65_RS01650	COG2091	lysine biosynthetic process via aminoadipic acid
B7L65_RS01665	COG0708	Exodeoxyribonuclease III
B7L65_RS01670	COG1846	Transcriptional regulator
B7L65_RS01670	COG1940	carbohydrate kinase activity
B7L65_RS01680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L65_RS01690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B7L65_RS01695	COG3162	membrane
B7L65_RS01705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B7L65_RS01735	COG3507	Belongs to the glycosyl hydrolase 43 family
B7L65_RS01755	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS01760	COG0179	Fumarylacetoacetate (FAA) hydrolase
B7L65_RS01770	COG4948	Mandelate Racemase Muconate Lactonizing
B7L65_RS01780	COG3254	rhamnose metabolic process
B7L65_RS01785	COG0738	Major facilitator superfamily
B7L65_RS01790	COG1414	Transcriptional regulator
B7L65_RS01795	COG1971	Probably functions as a manganese efflux pump
B7L65_RS01800	COG2205	protein histidine kinase activity
B7L65_RS01815	COG3459	Glycosyltransferase 36 associated
B7L65_RS01820	COG2211	Major facilitator Superfamily
B7L65_RS01825	COG3265	gluconokinase activity
B7L65_RS01835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L65_RS01855	COG2911	Protein conserved in bacteria
B7L65_RS01860	COG0729	surface antigen
B7L65_RS01890	COG0752	glycyl-tRNA synthetase alpha subunit
B7L65_RS01895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L65_RS01925	COG0519	Catalyzes the synthesis of GMP from XMP
B7L65_RS01925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B7L65_RS01935	COG0805	protein transport
B7L65_RS01940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B7L65_RS01945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B7L65_RS01955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B7L65_RS01980	COG2974	May be involved in recombination
B7L65_RS01995	COG2115	Belongs to the xylose isomerase family
B7L65_RS02005	COG3661	Belongs to the glycosyl hydrolase 67 family
B7L65_RS02015	COG4948	Mandelate Racemase Muconate Lactonizing
B7L65_RS02025	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L65_RS02030	COG0246	Mannitol dehydrogenase
B7L65_RS02080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B7L65_RS02110	COG3386	PFAM SMP-30 Gluconolaconase
B7L65_RS02120	COG3250	beta-galactosidase activity
B7L65_RS02125	COG1904	glucuronate isomerase
B7L65_RS02140	COG3693	PFAM glycoside hydrolase, family 10
B7L65_RS02155	COG2211	Major facilitator Superfamily
B7L65_RS02200	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L65_RS02210	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L65_RS02220	COG2234	aminopeptidase activity
B7L65_RS02230	COG4942	peptidase
B7L65_RS02235	COG0793	Belongs to the peptidase S41A family
B7L65_RS02295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L65_RS02305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B7L65_RS02335	COG0501	Belongs to the peptidase M48B family
B7L65_RS02345	COG0187	DNA topoisomerase II activity
B7L65_RS02350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B7L65_RS02360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B7L65_RS02375	COG0594	ribonuclease P activity
B7L65_RS02380	COG0706	membrane insertase activity
B7L65_RS02385	COG0726	polysaccharide deacetylase
B7L65_RS02390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B7L65_RS02405	COG0584	glycerophosphoryl diester phosphodiesterase
B7L65_RS02420	COG0861	Integral membrane protein TerC family
B7L65_RS02430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B7L65_RS02445	COG2271	Major facilitator Superfamily
B7L65_RS02450	COG1929	Belongs to the glycerate kinase type-1 family
B7L65_RS02455	COG3835	regulator
B7L65_RS02460	COG3706	GGDEF domain
B7L65_RS02475	COG3537	Alpha-1,2-mannosidase
B7L65_RS02480	COG0531	amino acid
B7L65_RS02490	COG0625	glutathione transferase activity
B7L65_RS02510	COG0604	alcohol dehydrogenase
B7L65_RS02515	COG1322	Protein conserved in bacteria
B7L65_RS02525	COG0386	Belongs to the glutathione peroxidase family
B7L65_RS02535	COG2853	Lipoprotein
B7L65_RS02550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B7L65_RS02555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B7L65_RS02560	COG1127	ABC transporter
B7L65_RS02575	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B7L65_RS02580	COG1074	ATP-dependent DNA helicase activity
B7L65_RS02620	COG0439	Biotin carboxylase
B7L65_RS02660	COG0564	pseudouridine synthase activity
B7L65_RS02685	COG1487	ribonuclease activity
B7L65_RS02690	COG4691	Plasmid stability protein
B7L65_RS02710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L65_RS02720	COG0477	Major facilitator Superfamily
B7L65_RS02725	COG1289	transmembrane transporter activity
B7L65_RS02735	COG1566	PFAM secretion protein HlyD family protein
B7L65_RS02750	COG0302	gtp cyclohydrolase
B7L65_RS02770	COG0730	response to heat
B7L65_RS02775	COG3012	SEC-C Motif Domain Protein
B7L65_RS02785	COG0676	glucose-6-phosphate 1-epimerase activity
B7L65_RS02805	COG3135	benzoate transporter
B7L65_RS02865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B7L65_RS02880	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B7L65_RS02910	COG0109	protoheme IX farnesyltransferase activity
B7L65_RS02925	COG0358	DNA primase activity
B7L65_RS02930	COG1295	ribonuclease BN
B7L65_RS02940	COG1610	YqeY-like protein
B7L65_RS02950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B7L65_RS02955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B7L65_RS02965	COG2133	pyrroloquinoline quinone binding
B7L65_RS02970	COG4682	membrane
B7L65_RS02985	COG0531	amino acid
B7L65_RS02995	COG4948	Mandelate Racemase Muconate Lactonizing
B7L65_RS03005	COG3023	N-Acetylmuramoyl-L-alanine amidase
B7L65_RS03010	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B7L65_RS03060	COG5383	Protein conserved in bacteria
B7L65_RS03070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L65_RS03075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L65_RS03080	COG1473	amidohydrolase
B7L65_RS03085	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B7L65_RS03085	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B7L65_RS03090	COG1652	LysM domain
B7L65_RS03115	COG1518	maintenance of DNA repeat elements
B7L65_RS03160	COG0583	DNA-binding transcription factor activity
B7L65_RS03165	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
B7L65_RS03175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B7L65_RS03185	COG3118	belongs to the thioredoxin family
B7L65_RS03190	COG0513	Belongs to the DEAD box helicase family
B7L65_RS03195	COG2884	Cell division ATP-binding protein ftsE
B7L65_RS03200	COG2177	Part of the ABC transporter FtsEX involved in
B7L65_RS03205	COG3437	response regulator, receiver
B7L65_RS03210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B7L65_RS03215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B7L65_RS03220	COG2860	membrane
B7L65_RS03225	COG1252	NADH dehydrogenase
B7L65_RS03240	COG0625	glutathione transferase activity
B7L65_RS03245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B7L65_RS03265	COG0534	Mate efflux family protein
B7L65_RS03270	COG0616	signal peptide processing
B7L65_RS03280	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS03295	COG0009	L-threonylcarbamoyladenylate synthase
B7L65_RS03300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L65_RS03300	COG1754	DNA topoisomerase type I activity
B7L65_RS03320	COG0758	DNA mediated transformation
B7L65_RS03325	COG1652	LysM domain
B7L65_RS03330	COG0242	peptide deformylase activity
B7L65_RS03335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B7L65_RS03340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B7L65_RS03340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B7L65_RS03395	COG1560	Kdo2-lipid A biosynthetic process
B7L65_RS03400	COG1490	D-aminoacyl-tRNA deacylase activity
B7L65_RS03405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B7L65_RS03500	COG0024	Methionine aminopeptidase
B7L65_RS03540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B7L65_RS03545	COG0583	DNA-binding transcription factor activity
B7L65_RS03560	COG0840	transmembrane signaling receptor activity
B7L65_RS03575	COG0251	oxidation-reduction process
B7L65_RS03650	COG1063	alcohol dehydrogenase
B7L65_RS03675	COG1132	(ABC) transporter
B7L65_RS03695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B7L65_RS03700	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS03715	COG1294	oxidase, subunit
B7L65_RS03720	COG1271	oxidase subunit
B7L65_RS03770	COG3546	catalase activity
B7L65_RS03775	COG3685	Protein conserved in bacteria
B7L65_RS03800	COG2972	Histidine kinase
B7L65_RS03815	COG0531	amino acid
B7L65_RS03835	COG3590	peptidase
B7L65_RS03850	COG0667	Aldo Keto reductase
B7L65_RS03860	COG0583	DNA-binding transcription factor activity
B7L65_RS03870	COG3384	dioxygenase
B7L65_RS03880	COG1573	uracil-dna glycosylase
B7L65_RS03885	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B7L65_RS03895	COG0025	NhaP-type Na H and K H
B7L65_RS03900	COG1131	(ABC) transporter
B7L65_RS03905	COG0842	Transport permease protein
B7L65_RS03970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L65_RS03975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B7L65_RS03995	COG2205	protein histidine kinase activity
B7L65_RS03995	COG2202	Pas domain
B7L65_RS04015	COG2813	Specifically methylates the guanine in position
B7L65_RS04020	COG1187	pseudouridine synthase activity
B7L65_RS04025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B7L65_RS04045	COG5002	protein histidine kinase activity
B7L65_RS04045	COG0784	Response regulator, receiver
B7L65_RS04045	COG2198	Histidine kinase
B7L65_RS04055	COG1666	GTP binding
B7L65_RS04060	COG0697	spore germination
B7L65_RS04065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B7L65_RS04070	COG2011	ABC-type metal ion transport system permease component
B7L65_RS04110	COG0508	dehydrogenase complex catalyzes the overall conversion of
B7L65_RS04120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L65_RS04140	COG0356	it plays a direct role in the translocation of protons across the membrane
B7L65_RS04150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B7L65_RS04155	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B7L65_RS04160	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B7L65_RS04165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B7L65_RS04170	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B7L65_RS04175	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B7L65_RS04190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B7L65_RS04195	COG4191	Histidine kinase
B7L65_RS04210	COG0577	efflux transmembrane transporter activity
B7L65_RS04215	COG0577	efflux transmembrane transporter activity
B7L65_RS04220	COG1136	(ABC) transporter
B7L65_RS04220	COG4591	ABC-type transport system involved in lipoprotein release permease component
B7L65_RS04225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L65_RS04230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B7L65_RS04285	COG0339	signal peptide processing
B7L65_RS04300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L65_RS04305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L65_RS04320	COG2819	hydrolase of the alpha beta superfamily
B7L65_RS04345	COG1956	GAF domain-containing protein
B7L65_RS04355	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B7L65_RS04365	COG0720	synthase
B7L65_RS04370	COG4206	TonB-dependent receptor
B7L65_RS04380	COG0513	Belongs to the DEAD box helicase family
B7L65_RS04395	COG0625	glutathione transferase activity
B7L65_RS04425	COG0626	cystathionine gamma-synthase activity
B7L65_RS04440	COG0110	maltose O-acetyltransferase activity
B7L65_RS04445	COG0438	transferase activity, transferring glycosyl groups
B7L65_RS04445	COG1216	Glycosyl transferase, family 2
B7L65_RS04450	COG3754	Rhamnan synthesis protein F
B7L65_RS04460	COG2226	methyltransferase
B7L65_RS04490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L65_RS04500	COG0300	oxidoreductase activity
B7L65_RS04505	COG0277	FAD linked oxidase domain protein
B7L65_RS04510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B7L65_RS04510	COG0546	phosphoglycolate phosphatase activity
B7L65_RS04525	COG2086	electron transfer activity
B7L65_RS04560	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B7L65_RS04560	COG0662	Cupin 2, conserved barrel domain protein
B7L65_RS04565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L65_RS04600	COG3218	ABC-type transport auxiliary lipoprotein component
B7L65_RS04600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B7L65_RS04605	COG1127	ABC transporter
B7L65_RS04610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B7L65_RS04625	COG0442	prolyl-tRNA aminoacylation
B7L65_RS04635	COG1183	phosphatidylcholine synthase activity
B7L65_RS04665	COG0525	valine-tRNA ligase activity
B7L65_RS04680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B7L65_RS04690	COG0795	lipopolysaccharide-transporting ATPase activity
B7L65_RS04705	COG4974	Belongs to the 'phage' integrase family
B7L65_RS04720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B7L65_RS04735	COG0047	phosphoribosylformylglycinamidine synthase activity
B7L65_RS04735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B7L65_RS04745	COG5295	Hep Hag repeat protein
B7L65_RS04750	COG1404	Belongs to the peptidase S8 family
B7L65_RS04755	COG5295	Hep Hag repeat protein
B7L65_RS04760	COG1404	Belongs to the peptidase S8 family
B7L65_RS04765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L65_RS04775	COG1459	type II secretion system
B7L65_RS04780	COG2165	general secretion pathway protein
B7L65_RS04785	COG4970	Tfp pilus assembly protein FimT
B7L65_RS04790	COG2165	general secretion pathway protein
B7L65_RS04795	COG4795	General secretion pathway protein
B7L65_RS04800	COG3156	type II secretion system protein K
B7L65_RS04805	COG3166	PFAM Fimbrial assembly family protein
B7L65_RS04820	COG1450	Type ii and iii secretion system protein
B7L65_RS04830	COG2188	Transcriptional regulator
B7L65_RS04885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B7L65_RS04900	COG1215	transferase activity, transferring glycosyl groups
B7L65_RS04905	COG1215	transferase activity, transferring glycosyl groups
B7L65_RS04910	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B7L65_RS04915	COG0457	Tetratricopeptide repeat
B7L65_RS04920	COG0457	Tetratricopeptide repeat
B7L65_RS04950	COG0242	peptide deformylase activity
B7L65_RS04955	COG1307	EDD domain protein, DegV family
B7L65_RS04990	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B7L65_RS04995	COG0726	polysaccharide deacetylase
B7L65_RS05000	COG4773	Receptor
B7L65_RS05030	COG1162	GTPase activity
B7L65_RS05055	COG2211	Major facilitator Superfamily
B7L65_RS05060	COG1609	Transcriptional regulator
B7L65_RS05065	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS05070	COG2851	Citrate transporter
B7L65_RS05090	COG0642	Histidine kinase
B7L65_RS05100	COG2197	response regulator
B7L65_RS05115	COG0667	Aldo Keto reductase
B7L65_RS05125	COG0583	DNA-binding transcription factor activity
B7L65_RS05150	COG1301	dicarboxylic acid transport
B7L65_RS05155	COG0280	phosphate acetyltransferase
B7L65_RS05155	COG0281	malic enzyme
B7L65_RS05180	COG1560	Kdo2-lipid A biosynthetic process
B7L65_RS05190	COG1519	Transferase
B7L65_RS05195	COG1538	Outer membrane efflux protein
B7L65_RS05200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B7L65_RS05220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B7L65_RS05225	COG0066	3-isopropylmalate dehydratase activity
B7L65_RS05230	COG0473	3-isopropylmalate dehydrogenase activity
B7L65_RS05235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B7L65_RS05255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B7L65_RS05260	COG0405	Gamma-glutamyltransferase
B7L65_RS05265	COG0840	transmembrane signaling receptor activity
B7L65_RS05280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B7L65_RS05285	COG3710	Transcriptional regulator
B7L65_RS05305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B7L65_RS05315	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B7L65_RS05330	COG0563	adenylate kinase activity
B7L65_RS05335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B7L65_RS05345	COG3781	membrane
B7L65_RS05350	COG0671	phosphoesterase, PA-phosphatase related
B7L65_RS05360	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS05365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L65_RS05370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B7L65_RS05400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L65_RS05415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B7L65_RS05430	COG0352	thiamine-phosphate diphosphorylase activity
B7L65_RS05435	COG1773	rubredoxin
B7L65_RS05440	COG2912	Transglutaminase-like superfamily
B7L65_RS05450	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B7L65_RS05460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B7L65_RS05480	COG3079	Belongs to the UPF0149 family
B7L65_RS05485	COG0006	proline dipeptidase activity
B7L65_RS05495	COG0006	proline dipeptidase activity
B7L65_RS05510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B7L65_RS05515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B7L65_RS05525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B7L65_RS05530	COG1561	YicC-like family, N-terminal region
B7L65_RS05535	COG0194	GDP metabolic process
B7L65_RS05545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B7L65_RS05555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B7L65_RS05580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B7L65_RS05615	COG0714	Associated with various cellular activities
B7L65_RS05635	COG2304	oxidoreductase activity
B7L65_RS05650	COG1301	dicarboxylic acid transport
B7L65_RS05655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B7L65_RS05660	COG0596	Alpha beta hydrolase
B7L65_RS05665	COG4773	Receptor
B7L65_RS05675	COG0739	heme binding
B7L65_RS05680	COG1376	ErfK ybiS ycfS ynhG family protein
B7L65_RS05715	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B7L65_RS05720	COG4149	molybdate abc transporter
B7L65_RS05725	COG0725	ABC transporter, periplasmic molybdate-binding protein
B7L65_RS05730	COG3453	Protein conserved in bacteria
B7L65_RS05730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L65_RS05740	COG3047	cAMP biosynthetic process
B7L65_RS05755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B7L65_RS05780	COG0126	phosphoglycerate kinase activity
B7L65_RS05790	COG0469	pyruvate kinase activity
B7L65_RS05805	COG3588	fructose-bisphosphate aldolase
B7L65_RS05810	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B7L65_RS05825	COG1648	precorrin-2 dehydrogenase activity
B7L65_RS05825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B7L65_RS05845	COG2205	protein histidine kinase activity
B7L65_RS05845	COG2198	Histidine kinase
B7L65_RS05845	COG0784	Response regulator, receiver
B7L65_RS05865	COG0175	sulfate reduction
B7L65_RS05870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7L65_RS05875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B7L65_RS05880	COG0175	sulfate reduction
B7L65_RS05885	COG2895	sulfate adenylyltransferase (ATP) activity
B7L65_RS05885	COG0529	Catalyzes the synthesis of activated sulfate
B7L65_RS05895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L65_RS05910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L65_RS05940	COG0784	Response regulator, receiver
B7L65_RS05940	COG4191	Histidine kinase
B7L65_RS05965	COG2003	Belongs to the UPF0758 family
B7L65_RS06065	COG0745	RESPONSE REGULATOR receiver
B7L65_RS06070	COG5002	protein histidine kinase activity
B7L65_RS06100	COG0237	dephospho-CoA kinase activity
B7L65_RS06105	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B7L65_RS06140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L65_RS06155	COG0045	succinate-CoA ligase (ADP-forming) activity
B7L65_RS06160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B7L65_RS06185	COG2369	cell adhesion
B7L65_RS06450	COG4191	Histidine kinase
B7L65_RS06450	COG0784	Response regulator, receiver
B7L65_RS06455	COG0745	RESPONSE REGULATOR receiver
B7L65_RS06520	COG4695	Portal protein
B7L65_RS06560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L65_RS06570	COG2201	protein-glutamate methylesterase activity
B7L65_RS06585	COG0544	peptidyl-prolyl cis-trans isomerase activity
B7L65_RS06595	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B7L65_RS06625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L65_RS06635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L65_RS06645	COG0328	RNA-DNA hybrid ribonuclease activity
B7L65_RS06650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B7L65_RS06655	COG0631	protein serine/threonine phosphatase activity
B7L65_RS06705	COG0859	PFAM glycosyl transferase family 9
B7L65_RS06710	COG3642	lipopolysaccharide core region biosynthetic process
B7L65_RS06715	COG1234	tRNA 3'-trailer cleavage
B7L65_RS06720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B7L65_RS06730	COG0315	cyclic pyranopterin monophosphate synthase activity
B7L65_RS06735	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B7L65_RS06740	COG0314	molybdopterin synthase activity
B7L65_RS06805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B7L65_RS06810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B7L65_RS06815	COG0537	adenosine 5'-monophosphoramidase activity
B7L65_RS06835	COG0714	Associated with various cellular activities
B7L65_RS06860	COG0424	maF-like protein
B7L65_RS06865	COG1399	metal-binding, possibly nucleic acid-binding protein
B7L65_RS06870	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B7L65_RS06875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L65_RS06890	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS06905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B7L65_RS06910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B7L65_RS06935	COG3829	transcription factor binding
B7L65_RS06955	COG3609	addiction module antidote protein, CC2985 family
B7L65_RS06990	COG2373	Large extracellular alpha-helical protein
B7L65_RS07010	COG4953	penicillin-binding protein 1C
B7L65_RS07020	COG0678	peroxiredoxin activity
B7L65_RS07040	COG0330	HflC and HflK could
B7L65_RS07045	COG0330	HflC and HflK could
B7L65_RS07055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B7L65_RS07060	COG0308	aminopeptidase N
B7L65_RS07065	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS07070	COG1309	transcriptional regulator
B7L65_RS07125	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B7L65_RS07160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B7L65_RS07170	COG3387	PFAM Glycoside hydrolase 15-related
B7L65_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS07185	COG3537	Alpha-1,2-mannosidase
B7L65_RS07205	COG0492	ferredoxin-NADP+ reductase activity
B7L65_RS07230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B7L65_RS07235	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B7L65_RS07240	COG2080	2 iron, 2 sulfur cluster binding
B7L65_RS07275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B7L65_RS07290	COG0587	DNA-directed DNA polymerase activity
B7L65_RS07310	COG1297	OPT oligopeptide transporter protein
B7L65_RS07325	COG1506	peptidase
B7L65_RS07325	COG0823	Involved in the tonB-independent uptake of proteins
B7L65_RS07340	COG1917	Cupin 2, conserved barrel domain protein
B7L65_RS07340	COG2207	Transcriptional regulator
B7L65_RS07370	COG0753	catalase activity
B7L65_RS07375	COG0656	L-ascorbic acid biosynthetic process
B7L65_RS07385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B7L65_RS07385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B7L65_RS07390	COG2814	Major facilitator Superfamily
B7L65_RS07405	COG2194	sulfuric ester hydrolase activity
B7L65_RS07420	COG0745	RESPONSE REGULATOR receiver
B7L65_RS07425	COG0642	Histidine kinase
B7L65_RS07435	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B7L65_RS07440	COG2894	cell division
B7L65_RS07445	COG0850	regulation of cytokinetic process
B7L65_RS07460	COG4585	Histidine kinase
B7L65_RS07465	COG2197	response regulator
B7L65_RS07480	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B7L65_RS07510	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B7L65_RS07520	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B7L65_RS07540	COG1946	Acyl-CoA thioesterase
B7L65_RS07555	COG0824	Thioesterase
B7L65_RS07560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B7L65_RS07565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B7L65_RS07570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B7L65_RS07575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B7L65_RS07580	COG0268	Binds directly to 16S ribosomal RNA
B7L65_RS07590	COG0196	riboflavin kinase activity
B7L65_RS07595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B7L65_RS07600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B7L65_RS07605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B7L65_RS07620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B7L65_RS07625	COG1845	cytochrome c oxidase, subunit III
B7L65_RS07630	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B7L65_RS07645	COG3152	Membrane
B7L65_RS07655	COG2207	Transcriptional regulator
B7L65_RS07660	COG0326	Molecular chaperone. Has ATPase activity
B7L65_RS07675	COG1366	Belongs to the anti-sigma-factor antagonist family
B7L65_RS07680	COG1366	Belongs to the anti-sigma-factor antagonist family
B7L65_RS07685	COG2172	sigma factor antagonist activity
B7L65_RS07710	COG4771	TonB-dependent receptor
B7L65_RS07720	COG5507	3-demethylubiquinone-9 3-methyltransferase
B7L65_RS07725	COG2205	protein histidine kinase activity
B7L65_RS07735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B7L65_RS07740	COG4999	Histidine kinase
B7L65_RS07740	COG3850	Histidine kinase
B7L65_RS07740	COG3437	response regulator, receiver
B7L65_RS07740	COG2205	protein histidine kinase activity
B7L65_RS07745	COG4191	Histidine kinase
B7L65_RS07745	COG0784	Response regulator, receiver
B7L65_RS07770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B7L65_RS07775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B7L65_RS07785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B7L65_RS07790	COG0228	four-way junction DNA binding
B7L65_RS07795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B7L65_RS07800	COG0336	Belongs to the RNA methyltransferase TrmD family
B7L65_RS07805	COG0335	large ribosomal subunit rRNA binding
B7L65_RS07810	COG0534	Mate efflux family protein
B7L65_RS07830	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B7L65_RS07840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B7L65_RS07865	COG3209	COG3209 Rhs family protein
B7L65_RS07890	COG3250	beta-galactosidase activity
B7L65_RS07895	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B7L65_RS07915	COG1960	acyl-CoA dehydrogenase activity
B7L65_RS07920	COG1024	Enoyl-CoA hydratase
B7L65_RS07940	COG1024	Enoyl-CoA hydratase
B7L65_RS07940	COG1250	3-hydroxyacyl-CoA dehydrogenase
B7L65_RS07955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7L65_RS07960	COG0481	GTPase activity
B7L65_RS07975	COG0571	ribonuclease III activity
B7L65_RS07980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B7L65_RS07985	COG1381	Involved in DNA repair and RecF pathway recombination
B7L65_RS07995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B7L65_RS08000	COG2954	triphosphatase activity
B7L65_RS08005	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B7L65_RS08010	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
B7L65_RS08015	COG3046	protein related to deoxyribodipyrimidine photolyase
B7L65_RS08020	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L65_RS08025	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B7L65_RS08030	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B7L65_RS08035	COG1278	Cold shock
B7L65_RS08040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L65_RS08050	COG1201	RNA secondary structure unwinding
B7L65_RS08055	COG1793	dna ligase
B7L65_RS08065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B7L65_RS08065	COG1793	dna ligase
B7L65_RS08100	COG0183	Belongs to the thiolase family
B7L65_RS08125	COG1451	nucleotide metabolic process
B7L65_RS08130	COG5487	UPF0391 membrane protein
B7L65_RS08140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B7L65_RS08155	COG1077	Cell shape determining protein MreB Mrl
B7L65_RS08160	COG1047	Peptidyl-prolyl cis-trans
B7L65_RS08170	COG2824	Alkylphosphonate utilization operon protein PhnA
B7L65_RS08180	COG1902	pentaerythritol trinitrate reductase activity
B7L65_RS08185	COG2814	Major facilitator Superfamily
B7L65_RS08220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B7L65_RS08220	COG0392	lysyltransferase activity
B7L65_RS08230	COG0251	oxidation-reduction process
B7L65_RS08235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L65_RS08250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L65_RS08275	COG1595	DNA-templated transcription, initiation
B7L65_RS08295	COG2878	Part of a membrane complex involved in electron transport
B7L65_RS08305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L65_RS08305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L65_RS08320	COG1131	(ABC) transporter
B7L65_RS08325	COG0346	lactoylglutathione lyase activity
B7L65_RS08330	COG0833	amino acid
B7L65_RS08335	COG2040	homocysteine
B7L65_RS08345	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B7L65_RS08365	COG1695	Transcriptional regulator
B7L65_RS08385	COG1981	membrane
B7L65_RS08400	COG0825	malonyl-CoA metabolic process
B7L65_RS08410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B7L65_RS08415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L65_RS08420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L65_RS08425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L65_RS08430	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L65_RS08445	COG0750	zinc metalloprotease
B7L65_RS08450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B7L65_RS08455	COG0575	Belongs to the CDS family
B7L65_RS08460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B7L65_RS08465	COG0233	cytoplasmic translational termination
B7L65_RS08470	COG0528	UMP kinase activity
B7L65_RS08480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B7L65_RS08485	COG0052	Belongs to the universal ribosomal protein uS2 family
B7L65_RS08525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B7L65_RS08535	COG1393	Belongs to the ArsC family
B7L65_RS08540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B7L65_RS08545	COG0367	asparagine synthase
B7L65_RS08555	COG4774	siderophore transport
B7L65_RS08570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B7L65_RS08600	COG1566	PFAM secretion protein HlyD family protein
B7L65_RS08605	COG2814	Major facilitator Superfamily
B7L65_RS08655	COG0339	signal peptide processing
B7L65_RS08665	COG0386	Belongs to the glutathione peroxidase family
B7L65_RS08720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B7L65_RS08725	COG0084	hydrolase, TatD family'
B7L65_RS08740	COG1960	acyl-CoA dehydrogenase activity
B7L65_RS08760	COG0367	asparagine synthase
B7L65_RS08770	COG0305	Participates in initiation and elongation during chromosome replication
B7L65_RS08775	COG0415	Belongs to the DNA photolyase family
B7L65_RS08795	COG0583	DNA-binding transcription factor activity
B7L65_RS08845	COG3706	GGDEF domain
B7L65_RS09010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B7L65_RS09025	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L65_RS09035	COG0497	DNA recombination
B7L65_RS09040	COG1420	regulation of RNA biosynthetic process
B7L65_RS09045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B7L65_RS09050	COG0443	Heat shock 70 kDa protein
B7L65_RS09055	COG0484	heat shock protein binding
B7L65_RS09065	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B7L65_RS09095	COG0583	DNA-binding transcription factor activity
B7L65_RS09100	COG1132	(ABC) transporter
B7L65_RS09135	COG2850	peptidyl-arginine hydroxylation
B7L65_RS09155	COG1253	flavin adenine dinucleotide binding
B7L65_RS09185	COG1131	(ABC) transporter
B7L65_RS09190	COG1725	Transcriptional regulator
B7L65_RS09200	COG0386	Belongs to the glutathione peroxidase family
B7L65_RS09215	COG2900	Belongs to the SlyX family
B7L65_RS09240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L65_RS09250	COG1410	methionine synthase
B7L65_RS09250	COG0646	methionine synthase
B7L65_RS09255	COG1410	methionine synthase
B7L65_RS09255	COG0646	methionine synthase
B7L65_RS09260	COG2226	methyltransferase
B7L65_RS09265	COG1960	acyl-CoA dehydrogenase activity
B7L65_RS09270	COG1960	acyl-CoA dehydrogenase activity
B7L65_RS09275	COG1960	acyl-CoA dehydrogenase activity
B7L65_RS09295	COG0557	exoribonuclease II activity
B7L65_RS09305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L65_RS09315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B7L65_RS09325	COG0704	Plays a role in the regulation of phosphate uptake
B7L65_RS09330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B7L65_RS09335	COG0581	inorganic phosphate transmembrane transporter activity
B7L65_RS09340	COG0573	inorganic phosphate transmembrane transporter activity
B7L65_RS09345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B7L65_RS09370	COG0659	secondary active sulfate transmembrane transporter activity
B7L65_RS09375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B7L65_RS09385	COG1024	Enoyl-CoA hydratase
B7L65_RS09395	COG0494	nUDIX hydrolase
B7L65_RS09430	COG0488	(ABC) transporter
B7L65_RS09440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B7L65_RS09440	COG0116	Belongs to the methyltransferase superfamily
B7L65_RS09445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B7L65_RS09470	COG2925	Exonuclease
B7L65_RS09480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L65_RS09485	COG3844	kynureninase activity
B7L65_RS09495	COG0662	Cupin 2, conserved barrel domain protein
B7L65_RS09500	COG0288	reversible hydration of carbon dioxide
B7L65_RS09565	COG2808	Putative FMN-binding domain
B7L65_RS09585	COG0017	Asparaginyl-tRNA synthetase
B7L65_RS09595	COG0316	Belongs to the HesB IscA family
B7L65_RS09600	COG0360	Binds together with S18 to 16S ribosomal RNA
B7L65_RS09605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B7L65_RS09610	COG0359	binds to the 23S rRNA
B7L65_RS09620	COG3115	cell septum assembly
B7L65_RS09630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L65_RS09635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B7L65_RS09640	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B7L65_RS09655	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B7L65_RS09665	COG4993	Dehydrogenase
B7L65_RS09675	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B7L65_RS09685	COG2986	histidine ammonia-lyase
B7L65_RS09690	COG1228	amidohydrolase
B7L65_RS09740	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B7L65_RS09745	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B7L65_RS09750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B7L65_RS09755	COG1605	Chorismate mutase
B7L65_RS09755	COG0077	Prephenate dehydratase
B7L65_RS09760	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B7L65_RS09775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B7L65_RS09780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B7L65_RS09785	COG0583	DNA-binding transcription factor activity
B7L65_RS09840	COG0556	nucleotide-excision repair
B7L65_RS09855	COG3505	Type IV secretory pathway VirD4
B7L65_RS09875	COG2948	multi-organism process
B7L65_RS09895	COG3702	type iv secretory pathway
B7L65_RS09965	COG0366	Alpha amylase catalytic
B7L65_RS09980	COG1082	Xylose isomerase domain protein TIM barrel
B7L65_RS10005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B7L65_RS10010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B7L65_RS10025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B7L65_RS10030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L65_RS10030	COG0072	phenylalanine-tRNA ligase activity
B7L65_RS10080	COG0438	transferase activity, transferring glycosyl groups
B7L65_RS10085	COG0438	transferase activity, transferring glycosyl groups
B7L65_RS10095	COG0438	transferase activity, transferring glycosyl groups
B7L65_RS10120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L65_RS10125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L65_RS10130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L65_RS10150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B7L65_RS10160	COG1960	acyl-CoA dehydrogenase activity
B7L65_RS10175	COG3040	lipid binding
B7L65_RS10190	COG0322	excinuclease ABC activity
B7L65_RS10205	COG0784	Response regulator, receiver
B7L65_RS10205	COG4191	Histidine kinase
B7L65_RS10210	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B7L65_RS10215	COG1194	a g-specific adenine glycosylase
B7L65_RS10225	COG0552	protein localization to endoplasmic reticulum
B7L65_RS10235	COG3938	Belongs to the proline racemase family
B7L65_RS10240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L65_RS10255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L65_RS10265	COG0006	proline dipeptidase activity
B7L65_RS10280	COG0531	amino acid
B7L65_RS10365	COG0326	Molecular chaperone. Has ATPase activity
B7L65_RS10370	COG0742	ribosomal rna small subunit methyltransferase
B7L65_RS10375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B7L65_RS10390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B7L65_RS10395	COG0405	Gamma-glutamyltransferase
B7L65_RS10400	COG3291	Pkd domain containing protein
B7L65_RS10405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B7L65_RS10440	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B7L65_RS10445	COG0343	queuine tRNA-ribosyltransferase activity
B7L65_RS10450	COG1862	Preprotein translocase
B7L65_RS10460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B7L65_RS10515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L65_RS10515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L65_RS10520	COG1105	Belongs to the carbohydrate kinase PfkB family
B7L65_RS10525	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L65_RS10525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L65_RS10530	COG1609	Transcriptional regulator
B7L65_RS10535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L65_RS10540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L65_RS10550	COG2902	Dehydrogenase
B7L65_RS10560	COG0477	Major facilitator Superfamily
B7L65_RS10570	COG2205	protein histidine kinase activity
B7L65_RS10570	COG0784	Response regulator, receiver
B7L65_RS10570	COG5002	protein histidine kinase activity
B7L65_RS10575	COG2733	membrane
B7L65_RS10585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B7L65_RS10600	COG2223	nitrite transmembrane transporter activity
B7L65_RS10605	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B7L65_RS10610	COG0243	molybdopterin cofactor binding
B7L65_RS10620	COG0477	Major facilitator Superfamily
B7L65_RS10625	COG2703	oxygen carrier activity
B7L65_RS10635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L65_RS10640	COG0174	glutamine synthetase
B7L65_RS10645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B7L65_RS10660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B7L65_RS10680	COG3842	ATPase activity
B7L65_RS10685	COG1176	ABC-type spermidine putrescine transport system, permease component I
B7L65_RS10690	COG1177	transmembrane transport
B7L65_RS10695	COG1012	belongs to the aldehyde dehydrogenase family
B7L65_RS10710	COG4535	Mg2 and Co2 transporter CorC
B7L65_RS10720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B7L65_RS10730	COG1702	phosphate starvation-inducible protein PhoH
B7L65_RS10735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L65_RS10750	COG0741	lytic transglycosylase activity
B7L65_RS10760	COG0723	plastoquinol--plastocyanin reductase activity
B7L65_RS10765	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B7L65_RS10770	COG2857	Cytochrome c1
B7L65_RS10775	COG0625	glutathione transferase activity
B7L65_RS10780	COG2969	positive regulation of protein catabolic process
B7L65_RS10800	COG1201	RNA secondary structure unwinding
B7L65_RS10805	COG2094	Belongs to the DNA glycosylase MPG family
B7L65_RS10810	COG0840	transmembrane signaling receptor activity
B7L65_RS10815	COG0835	chemotaxis
B7L65_RS11020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B7L65_RS11030	COG1570	exodeoxyribonuclease VII activity
B7L65_RS11035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L65_RS11040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B7L65_RS11040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B7L65_RS11045	COG0802	atpase or kinase
B7L65_RS11050	COG0860	N-Acetylmuramoyl-L-alanine amidase
B7L65_RS11055	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B7L65_RS11080	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS11085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L65_RS11090	COG0501	Belongs to the peptidase M48B family
B7L65_RS11100	COG2081	HI0933 family
B7L65_RS11105	COG4681	YaeQ
B7L65_RS11115	COG0625	glutathione transferase activity
B7L65_RS11125	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B7L65_RS11130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B7L65_RS11135	COG0513	Belongs to the DEAD box helicase family
B7L65_RS11140	COG0488	(ABC) transporter
B7L65_RS11160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B7L65_RS11165	COG0483	inositol monophosphate 1-phosphatase activity
B7L65_RS11180	COG3300	MHYT domain
B7L65_RS11180	COG5001	Diguanylate cyclase
B7L65_RS11185	COG1509	lysine 2,3-aminomutase activity
B7L65_RS11190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B7L65_RS11200	COG0402	S-adenosylhomocysteine deaminase activity
B7L65_RS11205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B7L65_RS11265	COG4302	ethanolamine ammonia-lyase activity
B7L65_RS11295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B7L65_RS11300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B7L65_RS11315	COG2166	iron-sulfur cluster assembly
B7L65_RS11320	COG0215	cysteine-tRNA ligase activity
B7L65_RS11330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B7L65_RS11335	COG0137	argininosuccinate synthase activity
B7L65_RS11345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B7L65_RS11350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B7L65_RS11360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B7L65_RS11365	COG0165	Argininosuccinate lyase
B7L65_RS11375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B7L65_RS11380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B7L65_RS11410	COG1294	oxidase, subunit
B7L65_RS11420	COG4988	ABC transporter
B7L65_RS11425	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B7L65_RS11430	COG1278	Cold shock
B7L65_RS11435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L65_RS11455	COG1138	Cytochrome C-type biogenesis protein
B7L65_RS11460	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B7L65_RS11480	COG4133	protoheme IX ABC transporter activity
B7L65_RS11485	COG0436	Aminotransferase
B7L65_RS11505	COG1187	pseudouridine synthase activity
B7L65_RS11510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B7L65_RS11515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B7L65_RS11520	COG2350	Protein conserved in bacteria
B7L65_RS11550	COG1175	transmembrane transport
B7L65_RS11555	COG0395	ABC-type sugar transport system, permease component
B7L65_RS11580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B7L65_RS11585	COG2957	Belongs to the agmatine deiminase family
B7L65_RS11605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B7L65_RS11610	COG0539	negative regulation of cytoplasmic translation
B7L65_RS11615	COG0776	regulation of translation
B7L65_RS11625	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B7L65_RS11630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7L65_RS11640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B7L65_RS11645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B7L65_RS11645	COG0475	glutathione-regulated potassium exporter activity
B7L65_RS11655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B7L65_RS11665	COG0519	Catalyzes the synthesis of GMP from XMP
B7L65_RS11665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B7L65_RS11670	COG0582	viral genome integration into host DNA
B7L65_RS11715	COG2003	Belongs to the UPF0758 family
B7L65_RS11735	COG2084	Dehydrogenase
B7L65_RS11815	COG0210	DNA helicase
B7L65_RS11865	COG3002	Belongs to the UPF0753 family
B7L65_RS11900	COG0641	radical SAM
B7L65_RS11915	COG2198	Histidine kinase
B7L65_RS11915	COG0643	Histidine kinase
B7L65_RS11915	COG0784	Response regulator, receiver
B7L65_RS11945	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B7L65_RS11975	COG1684	flagellar biosynthetic protein fliR
B7L65_RS11990	COG3190	flagellar
B7L65_RS12040	COG1677	Flagellar hook-basal body complex protein FliE
B7L65_RS12070	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS12075	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS12080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L65_RS12100	COG2201	protein-glutamate methylesterase activity
B7L65_RS12130	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B7L65_RS12135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B7L65_RS12140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B7L65_RS12150	COG3951	Flagellar rod assembly protein muramidase FlgJ
B7L65_RS12150	COG1705	Flagellar rod assembly protein muramidase FlgJ
B7L65_RS12155	COG1706	bacterial-type flagellum-dependent cell motility
B7L65_RS12160	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B7L65_RS12170	COG4787	bacterial-type flagellum-dependent cell motility
B7L65_RS12180	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B7L65_RS12185	COG1558	bacterial-type flagellum-dependent cell motility
B7L65_RS12195	COG0835	chemotaxis
B7L65_RS12195	COG0784	Response regulator, receiver
B7L65_RS12215	COG5002	protein histidine kinase activity
B7L65_RS12245	COG2915	High frequency lysogenization protein hflD homolog
B7L65_RS12250	COG0482	sulfurtransferase activity
B7L65_RS12265	COG0542	response to heat
B7L65_RS12275	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B7L65_RS12285	COG0492	ferredoxin-NADP+ reductase activity
B7L65_RS12290	COG1674	ftsk spoiiie
B7L65_RS12300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B7L65_RS12310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B7L65_RS12315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B7L65_RS12325	COG0183	Belongs to the thiolase family
B7L65_RS12330	COG1250	3-hydroxyacyl-CoA dehydrogenase
B7L65_RS12330	COG1024	Enoyl-CoA hydratase
B7L65_RS12345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B7L65_RS12355	COG1426	Protein conserved in bacteria
B7L65_RS12365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L65_RS12370	COG1160	GTP binding
B7L65_RS12375	COG0303	'Molybdopterin
B7L65_RS12380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B7L65_RS12420	COG0708	Exodeoxyribonuclease III
B7L65_RS12430	COG0303	'Molybdopterin
B7L65_RS12435	COG0746	molybdenum cofactor guanylyltransferase activity
B7L65_RS12450	COG1914	H( )-stimulated, divalent metal cation uptake system
B7L65_RS12465	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B7L65_RS12470	COG0668	transmembrane transport
B7L65_RS12480	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B7L65_RS12495	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS12500	COG1183	phosphatidylcholine synthase activity
B7L65_RS12510	COG3243	poly(R)-hydroxyalkanoic acid synthase
B7L65_RS12525	COG0723	plastoquinol--plastocyanin reductase activity
B7L65_RS12525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L65_RS12535	COG2183	response to ionizing radiation
B7L65_RS12540	COG2205	protein histidine kinase activity
B7L65_RS12540	COG0784	Response regulator, receiver
B7L65_RS12620	COG0800	Aldolase
B7L65_RS12625	COG0129	dihydroxy-acid dehydratase activity
B7L65_RS12630	COG0363	glucosamine-6-phosphate deaminase activity
B7L65_RS12635	COG0837	glucose binding
B7L65_RS12640	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B7L65_RS12665	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B7L65_RS12680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B7L65_RS12685	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B7L65_RS12695	COG4591	ABC-type transport system involved in lipoprotein release permease component
B7L65_RS12700	COG1136	(ABC) transporter
B7L65_RS12715	COG0811	peptide transport
B7L65_RS12725	COG1132	(ABC) transporter
B7L65_RS12730	COG1663	tetraacyldisaccharide 4'-kinase activity
B7L65_RS12735	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B7L65_RS12740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B7L65_RS12750	COG0322	excinuclease ABC activity
B7L65_RS12755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B7L65_RS12765	COG0582	viral genome integration into host DNA
B7L65_RS12790	COG1396	sequence-specific DNA binding
B7L65_RS12795	COG0583	DNA-binding transcription factor activity
B7L65_RS12945	COG2003	Belongs to the UPF0758 family
B7L65_RS13140	COG0270	DNA (cytosine-5-)-methyltransferase activity
B7L65_RS13145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L65_RS13150	COG0629	single-stranded DNA binding
B7L65_RS13230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B7L65_RS13245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B7L65_RS13295	COG3039	Transposase
B7L65_RS13330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L65_RS13335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L65_RS13350	COG0582	viral genome integration into host DNA
B7L65_RS13360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B7L65_RS13380	COG1054	Belongs to the UPF0176 family
B7L65_RS13390	COG1530	ribonuclease E activity
B7L65_RS13400	COG3064	Membrane
B7L65_RS13405	COG0428	transporter
B7L65_RS13415	COG2154	pterin-4-alpha-carbinolamine dehydratase
B7L65_RS13420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B7L65_RS13420	COG0316	Belongs to the HesB IscA family
B7L65_RS13465	COG1073	alpha beta
B7L65_RS13465	COG2226	methyltransferase
B7L65_RS13475	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS13630	COG1238	metal cluster binding
B7L65_RS13665	COG3279	Response regulator of the LytR AlgR family
B7L65_RS13715	COG4566	intracellular signal transduction
B7L65_RS13725	COG5001	Diguanylate cyclase
B7L65_RS13745	COG3685	Protein conserved in bacteria
B7L65_RS13770	COG1648	precorrin-2 dehydrogenase activity
B7L65_RS13770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B7L65_RS13785	COG2814	Major facilitator Superfamily
B7L65_RS13800	COG1335	isochorismatase
B7L65_RS13815	COG2197	response regulator
B7L65_RS13830	COG0583	DNA-binding transcription factor activity
B7L65_RS13835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B7L65_RS13840	COG3002	Belongs to the UPF0753 family
B7L65_RS13850	COG1396	sequence-specific DNA binding
B7L65_RS13855	COG5489	Protein of unknown function (DUF736)
B7L65_RS13860	COG2003	Belongs to the UPF0758 family
B7L65_RS13955	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B7L65_RS13960	COG1360	Flagellar Motor Protein
B7L65_RS13970	COG0835	chemotaxis
B7L65_RS13980	COG0745	RESPONSE REGULATOR receiver
B7L65_RS13985	COG2198	Histidine kinase
B7L65_RS13985	COG0643	Histidine kinase
B7L65_RS13990	COG0840	transmembrane signaling receptor activity
B7L65_RS14005	COG0840	transmembrane signaling receptor activity
B7L65_RS14020	COG0840	transmembrane signaling receptor activity
B7L65_RS14025	COG0840	transmembrane signaling receptor activity
B7L65_RS14030	COG0840	transmembrane signaling receptor activity
B7L65_RS14035	COG0840	transmembrane signaling receptor activity
B7L65_RS14045	COG0840	transmembrane signaling receptor activity
B7L65_RS14050	COG0840	transmembrane signaling receptor activity
B7L65_RS14055	COG0840	transmembrane signaling receptor activity
B7L65_RS14060	COG0840	transmembrane signaling receptor activity
B7L65_RS14065	COG0840	transmembrane signaling receptor activity
B7L65_RS14080	COG0835	chemotaxis
B7L65_RS14090	COG0840	transmembrane signaling receptor activity
B7L65_RS14100	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B7L65_RS14105	COG2201	protein-glutamate methylesterase activity
B7L65_RS14115	COG2267	carboxylic ester hydrolase activity
B7L65_RS14145	COG0318	PFAM AMP-dependent synthetase and ligase
B7L65_RS14150	COG1024	Enoyl-CoA hydratase
B7L65_RS14155	COG2205	protein histidine kinase activity
B7L65_RS14155	COG2198	Histidine kinase
B7L65_RS14155	COG0784	Response regulator, receiver
B7L65_RS14165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B7L65_RS14170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B7L65_RS14175	COG3279	Response regulator of the LytR AlgR family
B7L65_RS14215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B7L65_RS14225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L65_RS14230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B7L65_RS14240	COG0505	Belongs to the CarA family
B7L65_RS14245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B7L65_RS14250	COG2258	MOSC domain
B7L65_RS14255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L65_RS14300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B7L65_RS14320	COG0277	FAD linked oxidase domain protein
B7L65_RS14325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B7L65_RS14335	COG0531	amino acid
B7L65_RS14340	COG0531	amino acid
B7L65_RS14345	COG0235	Class ii aldolase
B7L65_RS14350	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B7L65_RS14355	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
B7L65_RS14370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B7L65_RS14370	COG0140	phosphoribosyl-ATP diphosphatase activity
B7L65_RS14375	COG0107	imidazoleglycerol-phosphate synthase activity
B7L65_RS14380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B7L65_RS14385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B7L65_RS14390	COG0131	Imidazoleglycerol-phosphate dehydratase
B7L65_RS14390	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B7L65_RS14395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L65_RS14400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B7L65_RS14405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B7L65_RS14415	COG0124	histidyl-tRNA synthetase
B7L65_RS14420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L65_RS14470	COG3210	domain, Protein
B7L65_RS14495	COG3210	domain, Protein
B7L65_RS14510	COG0726	polysaccharide deacetylase
B7L65_RS14510	COG1649	PFAM Uncharacterised BCR, COG1649
B7L65_RS14515	COG1215	transferase activity, transferring glycosyl groups
B7L65_RS14530	COG1012	belongs to the aldehyde dehydrogenase family
B7L65_RS14550	COG0167	dihydroorotate dehydrogenase activity
B7L65_RS14555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B7L65_RS14560	COG0697	spore germination
B7L65_RS14570	COG1794	racemase activity, acting on amino acids and derivatives
B7L65_RS14585	COG0671	phosphoesterase, PA-phosphatase related
B7L65_RS14590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B7L65_RS14605	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B7L65_RS14610	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L65_RS14620	COG5001	Diguanylate cyclase
B7L65_RS14620	COG4251	negative regulation of phosphorylation
B7L65_RS14620	COG3706	GGDEF domain
B7L65_RS14620	COG2203	Gaf domain
B7L65_RS14635	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L65_RS14660	COG0166	Belongs to the GPI family
B7L65_RS14665	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B7L65_RS14670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B7L65_RS14675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B7L65_RS14695	COG1469	GTP cyclohydrolase I activity
B7L65_RS14700	COG0860	N-Acetylmuramoyl-L-alanine amidase
B7L65_RS14730	COG0477	Major facilitator Superfamily
B7L65_RS14735	COG2115	Belongs to the xylose isomerase family
B7L65_RS14740	COG1070	Carbohydrate kinase
B7L65_RS14750	COG1501	Belongs to the glycosyl hydrolase 31 family
B7L65_RS14790	COG0800	Aldolase
B7L65_RS14795	COG4948	Mandelate Racemase Muconate Lactonizing
B7L65_RS14805	COG3734	2-keto-3-deoxy-galactonokinase
B7L65_RS14810	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B7L65_RS14820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L65_RS14835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B7L65_RS14840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B7L65_RS14855	COG0351	phosphomethylpyrimidine kinase
B7L65_RS14855	COG0352	thiamine-phosphate diphosphorylase activity
B7L65_RS14880	COG0583	DNA-binding transcription factor activity
B7L65_RS14885	COG1741	Belongs to the pirin family
B7L65_RS14905	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B7L65_RS14910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B7L65_RS14915	COG2137	regulation of response to DNA damage stimulus
B7L65_RS14925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B7L65_RS14930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B7L65_RS14940	COG1546	Belongs to the CinA family
B7L65_RS14945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B7L65_RS14955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B7L65_RS14960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B7L65_RS14970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B7L65_RS14975	COG1534	Rna-binding protein
B7L65_RS14990	COG1238	metal cluster binding
B7L65_RS14995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B7L65_RS15000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B7L65_RS15005	COG2840	Smr protein MutS2
B7L65_RS15010	COG0585	pseudouridine synthase activity
B7L65_RS15015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B7L65_RS15020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B7L65_RS15025	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B7L65_RS15030	COG0148	phosphopyruvate hydratase activity
B7L65_RS15040	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B7L65_RS15045	COG0504	CTP synthase activity
B7L65_RS15070	COG0306	phosphate transporter
B7L65_RS15085	COG1253	flavin adenine dinucleotide binding
B7L65_RS15100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L65_RS15105	COG0477	Major facilitator Superfamily
B7L65_RS15115	COG1136	(ABC) transporter
B7L65_RS15130	COG0438	transferase activity, transferring glycosyl groups
B7L65_RS15140	COG2264	protein methyltransferase activity
B7L65_RS15175	COG2244	polysaccharide biosynthetic process
B7L65_RS15230	COG1595	DNA-templated transcription, initiation
B7L65_RS15245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B7L65_RS15255	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B7L65_RS15265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7L65_RS15280	COG0784	Response regulator, receiver
B7L65_RS15280	COG4191	Histidine kinase
B7L65_RS15285	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
B7L65_RS15320	COG0840	transmembrane signaling receptor activity
B7L65_RS15390	COG3275	phosphorelay sensor kinase activity
B7L65_RS15395	COG1611	Belongs to the LOG family
B7L65_RS15410	COG2095	MarC family integral membrane protein
B7L65_RS15420	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B7L65_RS15455	COG1185	polyribonucleotide nucleotidyltransferase activity
B7L65_RS15460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B7L65_RS15465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B7L65_RS15470	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B7L65_RS15475	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B7L65_RS15480	COG0195	Participates in both transcription termination and antitermination
B7L65_RS15485	COG0779	Required for maturation of 30S ribosomal subunits
B7L65_RS15495	COG1007	ATP synthesis coupled electron transport
B7L65_RS15520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L65_RS15525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B7L65_RS15535	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B7L65_RS15540	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B7L65_RS15545	COG0649	NAD binding
B7L65_RS15550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L65_RS15555	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L65_RS15560	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L65_RS15575	COG0149	triose-phosphate isomerase activity
B7L65_RS15580	COG0300	oxidoreductase activity
B7L65_RS15610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L65_RS15615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B7L65_RS15620	COG0159	tryptophan synthase activity
B7L65_RS15630	COG0133	tryptophan synthase activity
B7L65_RS15640	COG0135	phosphoribosylanthranilate isomerase activity
B7L65_RS15645	COG0101	tRNA pseudouridine synthase activity
B7L65_RS15665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B7L65_RS15670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B7L65_RS15675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B7L65_RS15680	COG2890	protein-(glutamine-N5) methyltransferase activity
B7L65_RS15690	COG0688	phosphatidylethanolamine metabolic process
B7L65_RS15705	COG0433	COG0433 Predicted ATPase
B7L65_RS15710	COG0494	nUDIX hydrolase
B7L65_RS15730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L65_RS15735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L65_RS15760	COG0717	Belongs to the dCTP deaminase family
B7L65_RS15770	COG0489	protein tyrosine kinase activity
B7L65_RS15790	COG3590	peptidase
B7L65_RS15800	COG3590	peptidase
B7L65_RS15820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L65_RS15825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L65_RS15830	COG2311	Membrane
B7L65_RS15835	COG1047	Peptidyl-prolyl cis-trans
B7L65_RS15840	COG0791	NLP P60 protein
B7L65_RS15845	COG0791	NLP P60 protein
B7L65_RS15855	COG4106	trans-aconitate 2-methyltransferase activity
B7L65_RS15860	COG1301	dicarboxylic acid transport
B7L65_RS15865	COG1785	Belongs to the alkaline phosphatase family
B7L65_RS15875	COG0037	tRNA processing
B7L65_RS15880	COG1722	exodeoxyribonuclease VII activity
B7L65_RS15885	COG0142	geranyltranstransferase activity
B7L65_RS15890	COG4104	PAAR repeat-containing protein
B7L65_RS15900	COG0312	modulator of DNA gyrase
B7L65_RS15905	COG3028	Belongs to the UPF0307 family
B7L65_RS15910	COG0312	modulator of DNA gyrase
B7L65_RS15920	COG3164	Protein of unknown function
B7L65_RS15930	COG0424	maF-like protein
B7L65_RS15935	COG2968	Membrane
B7L65_RS15950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B7L65_RS15965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B7L65_RS15980	COG0495	leucyl-tRNA aminoacylation
B7L65_RS15990	COG3118	belongs to the thioredoxin family
B7L65_RS16015	COG2155	Conserved Protein
B7L65_RS16060	COG1132	(ABC) transporter
B7L65_RS16090	COG1538	Outer membrane efflux protein
B7L65_RS16095	COG0745	RESPONSE REGULATOR receiver
B7L65_RS16100	COG5002	protein histidine kinase activity
B7L65_RS16100	COG5000	phosphorelay sensor kinase activity
B7L65_RS16105	COG0475	glutathione-regulated potassium exporter activity
B7L65_RS16115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B7L65_RS16140	COG1187	pseudouridine synthase activity
B7L65_RS16145	COG5001	Diguanylate cyclase
B7L65_RS16145	COG5002	protein histidine kinase activity
B7L65_RS16265	COG0667	Aldo Keto reductase
B7L65_RS16270	COG2814	Major facilitator Superfamily
B7L65_RS16275	COG0583	DNA-binding transcription factor activity
B7L65_RS16285	COG2207	Transcriptional regulator
B7L65_RS16295	COG1309	transcriptional regulator
B7L65_RS16305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L65_RS16320	COG0735	belongs to the Fur family
B7L65_RS16325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L65_RS16350	COG4452	Inner membrane protein CreD
B7L65_RS16360	COG2205	protein histidine kinase activity
B7L65_RS16365	COG0745	RESPONSE REGULATOR receiver
B7L65_RS16370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B7L65_RS16380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B7L65_RS16430	COG0643	Histidine kinase
B7L65_RS16430	COG2198	Histidine kinase
B7L65_RS16440	COG0840	transmembrane signaling receptor activity
B7L65_RS16445	COG0835	chemotaxis
B7L65_RS16450	COG2200	EAL domain
B7L65_RS16450	COG2202	Pas domain
B7L65_RS16450	COG2199	diguanylate cyclase activity
B7L65_RS16455	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B7L65_RS16460	COG2201	protein-glutamate methylesterase activity
B7L65_RS16465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L65_RS16470	COG3590	peptidase
B7L65_RS16480	COG0588	phosphoglycerate mutase activity
B7L65_RS16485	COG1515	deoxyribonuclease V activity
B7L65_RS16495	COG1741	Belongs to the pirin family
B7L65_RS16510	COG1741	Belongs to the pirin family
B7L65_RS16515	COG1966	Carbon starvation protein
B7L65_RS16520	COG2879	small protein
B7L65_RS16570	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B7L65_RS16575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B7L65_RS16580	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B7L65_RS16585	COG2080	2 iron, 2 sulfur cluster binding
B7L65_RS16595	COG3706	GGDEF domain
B7L65_RS16595	COG2203	Gaf domain
B7L65_RS16595	COG4251	negative regulation of phosphorylation
B7L65_RS16595	COG5001	Diguanylate cyclase
B7L65_RS16600	COG0629	single-stranded DNA binding
B7L65_RS16605	COG0142	geranyltranstransferase activity
B7L65_RS16620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B7L65_RS16635	COG0527	aspartate kinase activity
B7L65_RS16640	COG0384	phenazine biosynthesis protein PhzF
B7L65_RS16645	COG0384	phenazine biosynthesis protein PhzF
B7L65_RS16655	COG1764	response to oxidative stress
B7L65_RS16660	COG0540	Belongs to the ATCase OTCase family
B7L65_RS16665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B7L65_RS16670	COG1678	Uncharacterized ACR, COG1678
B7L65_RS16680	COG0519	Catalyzes the synthesis of GMP from XMP
B7L65_RS16690	COG5297	Belongs to the glycosyl hydrolase family 6
B7L65_RS16705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B7L65_RS16720	COG0739	heme binding
B7L65_RS16740	COG0693	protein deglycase activity
B7L65_RS16750	COG1959	2 iron, 2 sulfur cluster binding
B7L65_RS16755	COG0719	Fe-S assembly protein
B7L65_RS16760	COG0396	ATPase activity
B7L65_RS16765	COG0719	Fe-S assembly protein
B7L65_RS16770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B7L65_RS16780	COG2146	nitrite reductase [NAD(P)H] activity
B7L65_RS16785	COG4774	siderophore transport
B7L65_RS16790	COG3128	pkhd-type hydroxylase
B7L65_RS16815	COG1477	protein flavinylation
B7L65_RS16820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B7L65_RS16835	COG1555	photosystem II stabilization
B7L65_RS16840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B7L65_RS16850	COG3178	'Phosphotransferase
B7L65_RS16855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B7L65_RS16865	COG0628	permease
B7L65_RS16875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B7L65_RS16885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B7L65_RS16905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B7L65_RS16910	COG0271	Belongs to the BolA IbaG family
B7L65_RS16920	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B7L65_RS16930	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B7L65_RS16935	COG1137	ATPase activity
B7L65_RS16950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L65_RS16955	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B7L65_RS16960	COG1660	Displays ATPase and GTPase activities
B7L65_RS16970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L65_RS16975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L65_RS16985	COG2239	Acts as a magnesium transporter
B7L65_RS17000	COG1294	oxidase, subunit
B7L65_RS17005	COG1271	oxidase subunit
B7L65_RS17015	COG1113	amino acid transport
B7L65_RS17045	COG2197	response regulator
B7L65_RS17050	COG0531	amino acid
B7L65_RS17085	COG1234	tRNA 3'-trailer cleavage
B7L65_RS17130	COG2814	Major facilitator Superfamily
B7L65_RS17140	COG0754	glutathionylspermidine amidase activity
B7L65_RS17165	COG1842	Phage shock protein A
B7L65_RS17175	COG0259	pyridoxamine-phosphate oxidase activity
B7L65_RS17180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B7L65_RS17185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B7L65_RS17195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B7L65_RS17270	COG0477	Major facilitator Superfamily
B7L65_RS17290	COG2198	Histidine kinase
B7L65_RS17290	COG2205	protein histidine kinase activity
B7L65_RS17290	COG0784	Response regulator, receiver
B7L65_RS17295	COG2353	YceI-like domain
B7L65_RS17315	COG1760	l-serine dehydratase
B7L65_RS17330	COG0527	aspartate kinase activity
B7L65_RS17330	COG0460	homoserine dehydrogenase
B7L65_RS17335	COG0626	cystathionine gamma-synthase activity
B7L65_RS17340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L65_RS17345	COG0739	heme binding
B7L65_RS17350	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B7L65_RS17355	COG1272	protein, Hemolysin III
B7L65_RS17360	COG2982	Protein involved in outer membrane biogenesis
B7L65_RS17365	COG0516	GMP reductase activity
B7L65_RS17365	COG0517	IMP dehydrogenase activity
B7L65_RS17370	COG0463	Glycosyl transferase, family 2
B7L65_RS17375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B7L65_RS17380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B7L65_RS17390	COG4771	TonB-dependent receptor
B7L65_RS17400	COG1309	transcriptional regulator
B7L65_RS17410	COG1960	acyl-CoA dehydrogenase activity
B7L65_RS17435	COG0509	glycine decarboxylation via glycine cleavage system
B7L65_RS17440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B7L65_RS17450	COG0330	HflC and HflK could
B7L65_RS17455	COG1742	UPF0060 membrane protein
B7L65_RS17460	COG3956	TIGRFAM MazG family protein
B7L65_RS17470	COG0494	nUDIX hydrolase
B7L65_RS17480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B7L65_RS17485	COG0837	glucose binding
B7L65_RS17500	COG3858	chitin binding
B7L65_RS17500	COG1388	LysM domain
B7L65_RS17515	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L65_RS17530	COG0531	amino acid
B7L65_RS17540	COG1486	melibiose metabolic process
B7L65_RS17550	COG3537	Alpha-1,2-mannosidase
B7L65_RS17590	COG3142	Participates in the control of copper homeostasis
B7L65_RS17595	COG1446	asparaginase
B7L65_RS17630	COG0643	Histidine kinase
B7L65_RS17630	COG0784	Response regulator, receiver
B7L65_RS17630	COG2198	Histidine kinase
B7L65_RS17635	COG0840	transmembrane signaling receptor activity
B7L65_RS17640	COG0835	chemotaxis
B7L65_RS17655	COG0189	ligase activity
B7L65_RS17665	COG1397	ADP-ribosylglycohydrolase
B7L65_RS17675	COG1199	ATP-dependent helicase activity
B7L65_RS17685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B7L65_RS17690	COG1215	transferase activity, transferring glycosyl groups
B7L65_RS17715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B7L65_RS17725	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B7L65_RS17730	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
B7L65_RS17735	COG0535	radical SAM domain protein
B7L65_RS17740	COG0535	radical SAM domain protein
B7L65_RS17755	COG0837	glucose binding
B7L65_RS17770	COG1643	Atp-dependent helicase
B7L65_RS17775	COG0783	Belongs to the Dps family
B7L65_RS17785	COG0514	ATP-dependent DNA helicase (RecQ)
B7L65_RS17820	COG0840	transmembrane signaling receptor activity
B7L65_RS17855	COG3920	Histidine kinase
B7L65_RS17860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B7L65_RS17870	COG0602	queuosine metabolic process
B7L65_RS17880	COG2885	chlorophyll binding
B7L65_RS17885	COG0823	Involved in the tonB-independent uptake of proteins
B7L65_RS17895	COG0848	biopolymer transport protein
B7L65_RS17905	COG0824	Thioesterase
B7L65_RS17910	COG2255	four-way junction helicase activity
B7L65_RS17920	COG3158	transport of potassium into the cell
B7L65_RS17925	COG0632	four-way junction helicase activity
B7L65_RS17930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B7L65_RS17935	COG0217	transcriptional regulatory protein
B7L65_RS17950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B7L65_RS17965	COG0477	Major facilitator Superfamily
B7L65_RS18010	COG0488	(ABC) transporter
B7L65_RS18050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B7L65_RS18050	COG4651	solute:proton antiporter activity
B7L65_RS18075	COG4772	TonB-dependent receptor
B7L65_RS18085	COG4264	IucA IucC family
B7L65_RS18100	COG0019	diaminopimelate decarboxylase activity
B7L65_RS18125	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B7L65_RS18135	COG1492	cobalamin metabolic process
B7L65_RS18145	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B7L65_RS18165	COG4206	TonB-dependent receptor
B7L65_RS18170	COG0542	response to heat
B7L65_RS18175	COG1116	anion transmembrane transporter activity
B7L65_RS18180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L65_RS18185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B7L65_RS18190	COG0667	Aldo Keto reductase
B7L65_RS18195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L65_RS18200	COG4771	TonB-dependent receptor
B7L65_RS18205	COG2827	Endonuclease containing a URI domain
B7L65_RS18245	COG1877	trehalose-phosphatase activity
B7L65_RS18250	COG3387	PFAM Glycoside hydrolase 15-related
B7L65_RS18270	COG0840	transmembrane signaling receptor activity
B7L65_RS18275	COG3011	Protein conserved in bacteria
B7L65_RS18290	COG0564	pseudouridine synthase activity
B7L65_RS18295	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L65_RS18305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B7L65_RS18305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B7L65_RS18330	COG2951	lytic endotransglycosylase activity
B7L65_RS18335	COG4644	lycopene metabolic process
B7L65_RS18420	COG0473	3-isopropylmalate dehydrogenase activity
B7L65_RS18435	COG4783	chaperone-mediated protein folding
B7L65_RS18450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B7L65_RS18460	COG0438	transferase activity, transferring glycosyl groups
B7L65_RS18465	COG0671	phosphoesterase, PA-phosphatase related
B7L65_RS18470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L65_RS18480	COG3291	Pkd domain containing protein
B7L65_RS18490	COG2833	Protein of unknown function (DUF455)
B7L65_RS18510	COG0285	dihydrofolate synthase activity
B7L65_RS18515	COG0406	alpha-ribazole phosphatase activity
B7L65_RS18545	COG1063	alcohol dehydrogenase
B7L65_RS18555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B7L65_RS18560	COG4208	sulfate ABC transporter
B7L65_RS18565	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B7L65_RS18570	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B7L65_RS18575	COG0156	8-amino-7-oxononanoate synthase activity
B7L65_RS18605	COG0604	alcohol dehydrogenase
B7L65_RS18610	COG1902	pentaerythritol trinitrate reductase activity
B7L65_RS18610	COG0446	pyridine nucleotide-disulphide oxidoreductase
B7L65_RS18630	COG0625	glutathione transferase activity
B7L65_RS18635	COG0039	L-malate dehydrogenase activity
B7L65_RS18640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B7L65_RS18645	COG1217	gtp-binding protein TYPA
B7L65_RS18655	COG0154	amidase activity
B7L65_RS18665	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B7L65_RS18685	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B7L65_RS18690	COG0203	ribosomal protein L17
B7L65_RS18715	COG0201	protein transport
B7L65_RS18720	COG0200	Binds to the 23S rRNA
B7L65_RS18725	COG1841	ribosomal large subunit assembly
B7L65_RS18735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B7L65_RS18740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B7L65_RS18745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B7L65_RS18755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B7L65_RS18760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B7L65_RS18770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B7L65_RS18775	COG0255	Belongs to the universal ribosomal protein uL29 family
B7L65_RS18780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B7L65_RS18785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B7L65_RS18795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B7L65_RS18800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B7L65_RS18805	COG0089	rRNA binding
B7L65_RS18810	COG0088	Forms part of the polypeptide exit tunnel
B7L65_RS18815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B7L65_RS18820	COG0051	transcription antitermination factor activity, RNA binding
B7L65_RS18825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B7L65_RS18830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B7L65_RS18835	COG0049	tRNA binding
B7L65_RS18840	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B7L65_RS18845	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B7L65_RS18850	COG0085	RNA polymerase activity
B7L65_RS18855	COG0222	ribosome binding
B7L65_RS18860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B7L65_RS18865	COG0081	regulation of translation
B7L65_RS18870	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B7L65_RS18875	COG0250	Participates in transcription elongation, termination and antitermination
B7L65_RS18890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B7L65_RS18910	COG0012	GTP binding
B7L65_RS18915	COG0193	aminoacyl-tRNA hydrolase activity
B7L65_RS18920	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B7L65_RS18925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B7L65_RS18935	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B7L65_RS18940	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B7L65_RS18955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B7L65_RS18965	COG0521	Mo-molybdopterin cofactor biosynthetic process
B7L65_RS18985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7L65_RS18990	COG1295	ribonuclease BN
B7L65_RS19015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B7L65_RS19020	COG1404	Belongs to the peptidase S8 family
B7L65_RS19030	COG1404	Belongs to the peptidase S8 family
B7L65_RS19035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B7L65_RS19050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B7L65_RS19075	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B7L65_RS19105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7L65_RS19105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7L65_RS19125	COG2890	protein-(glutamine-N5) methyltransferase activity
B7L65_RS19135	COG3634	alkyl hydroperoxide reductase activity
B7L65_RS19140	COG0583	DNA-binding transcription factor activity
B7L65_RS19150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L65_RS19155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B7L65_RS19165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B7L65_RS19175	COG2197	response regulator
B7L65_RS19180	COG2205	protein histidine kinase activity
B7L65_RS19180	COG0784	Response regulator, receiver
B7L65_RS19180	COG5002	protein histidine kinase activity
B7L65_RS19200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L65_RS19210	COG0697	spore germination
B7L65_RS19235	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B7L65_RS19250	COG3386	PFAM SMP-30 Gluconolaconase
B7L65_RS19270	COG1024	Enoyl-CoA hydratase
B7L65_RS19285	COG0583	DNA-binding transcription factor activity
B7L65_RS19290	COG3384	dioxygenase
B7L65_RS19320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L65_RS19325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L65_RS19340	COG2096	Adenosyltransferase
B7L65_RS19345	COG0123	including yeast histone deacetylase and acetoin utilization protein
B7L65_RS19360	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B7L65_RS19365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L65_RS19370	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B7L65_RS19375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B7L65_RS19380	COG2967	ApaG domain
B7L65_RS19385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B7L65_RS19395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7L65_RS19405	COG0747	negative chemotaxis
B7L65_RS19430	COG0431	NADPH-dependent FMN reductase
B7L65_RS19435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L65_RS19445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L65_RS19450	COG1116	anion transmembrane transporter activity
B7L65_RS19460	COG3829	transcription factor binding
B7L65_RS19475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B7L65_RS19480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B7L65_RS19500	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B7L65_RS19515	COG0642	Histidine kinase
B7L65_RS19530	COG4181	ATPase activity
B7L65_RS19540	COG2175	clavaminate synthase activity
B7L65_RS19550	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B7L65_RS19555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L65_RS19575	COG4771	TonB-dependent receptor
B7L65_RS19585	COG0667	Aldo Keto reductase
B7L65_RS19595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B7L65_RS19600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L65_RS19610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B7L65_RS19615	COG4106	trans-aconitate 2-methyltransferase activity
B7L65_RS19625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B7L65_RS19670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B7L65_RS19680	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B7L65_RS19685	COG2226	methyltransferase
B7L65_RS19720	COG0366	Alpha amylase catalytic
B7L65_RS19750	COG0604	alcohol dehydrogenase
B7L65_RS19750	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS19750	COG3321	synthase
B7L65_RS19765	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B7L65_RS19775	COG0494	nUDIX hydrolase
B7L65_RS19780	COG0653	protein targeting
B7L65_RS19785	COG0739	heme binding
B7L65_RS19795	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B7L65_RS19810	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B7L65_RS19815	COG1181	Belongs to the D-alanine--D-alanine ligase family
B7L65_RS19820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B7L65_RS19825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B7L65_RS19835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7L65_RS19840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B7L65_RS19845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B7L65_RS19855	COG3116	cell division
B7L65_RS19860	COG0275	rRNA processing
B7L65_RS19895	COG0792	nuclease activity
B7L65_RS19900	COG1988	membrane-bound metal-dependent
B7L65_RS19905	COG0277	FAD linked oxidase domain protein
B7L65_RS19920	COG0745	RESPONSE REGULATOR receiver
B7L65_RS19925	COG2205	protein histidine kinase activity
B7L65_RS19930	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B7L65_RS19935	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B7L65_RS19940	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B7L65_RS19965	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B7L65_RS19970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B7L65_RS19975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B7L65_RS19995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L65_RS19995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L65_RS20005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B7L65_RS20010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B7L65_RS20020	COG0488	(ABC) transporter
B7L65_RS20030	COG0697	spore germination
B7L65_RS20040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L65_RS20055	COG3791	Glutathione-dependent formaldehyde-activating
B7L65_RS20085	COG2205	protein histidine kinase activity
B7L65_RS20105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B7L65_RS20110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B7L65_RS20125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B7L65_RS20140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B7L65_RS20145	COG1012	belongs to the aldehyde dehydrogenase family
B7L65_RS20150	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B7L65_RS20155	COG0617	tRNA 3'-terminal CCA addition
B7L65_RS20165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B7L65_RS20170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B7L65_RS20175	COG1609	Transcriptional regulator
B7L65_RS20185	COG2188	Transcriptional regulator
B7L65_RS20200	COG3250	beta-galactosidase activity
B7L65_RS20250	COG1459	type II secretion system
B7L65_RS20310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B7L65_RS20315	COG4191	Histidine kinase
B7L65_RS20320	COG0784	Response regulator, receiver
B7L65_RS20325	COG4251	negative regulation of phosphorylation
B7L65_RS20330	COG2823	Periplasmic or secreted lipoprotein
B7L65_RS20335	COG0673	inositol 2-dehydrogenase activity
B7L65_RS20340	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B7L65_RS20375	COG1056	cytidyltransferase-related domain
B7L65_RS20375	COG1051	belongs to the nudix hydrolase family
B7L65_RS20385	COG0583	DNA-binding transcription factor activity
B7L65_RS20400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B7L65_RS20405	COG0321	lipoyl(octanoyl) transferase activity
B7L65_RS20410	COG2921	Belongs to the UPF0250 family
B7L65_RS20420	COG1686	Belongs to the peptidase S11 family
B7L65_RS20430	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B7L65_RS20435	COG2951	lytic endotransglycosylase activity
B7L65_RS20445	COG0772	Belongs to the SEDS family
B7L65_RS20460	COG1792	Involved in formation and maintenance of cell shape
B7L65_RS20465	COG1077	Cell shape determining protein MreB Mrl
B7L65_RS20470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L65_RS20475	COG3284	Transcriptional regulator
B7L65_RS20525	COG0308	aminopeptidase N
B7L65_RS20530	COG5001	Diguanylate cyclase
B7L65_RS20530	COG3300	MHYT domain
B7L65_RS20535	COG2226	methyltransferase
B7L65_RS20560	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B7L65_RS20565	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B7L65_RS20570	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B7L65_RS20580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B7L65_RS20590	COG2832	Protein of unknown function (DUF454)
B7L65_RS20605	COG0436	Aminotransferase
B7L65_RS20610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B7L65_RS20615	COG1505	serine-type exopeptidase activity
B7L65_RS20645	COG0181	hydroxymethylbilane synthase activity
B7L65_RS20655	COG3275	phosphorelay sensor kinase activity
B7L65_RS20665	COG2943	transferase activity, transferring hexosyl groups
B7L65_RS20700	COG5297	Belongs to the glycosyl hydrolase family 6
B7L65_RS20700	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L65_RS20705	COG0840	transmembrane signaling receptor activity
B7L65_RS20710	COG5001	Diguanylate cyclase
B7L65_RS20765	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
B7L65_RS20785	COG1113	amino acid transport
B7L65_RS20800	COG0697	spore germination
B7L65_RS20845	COG0823	Involved in the tonB-independent uptake of proteins
B7L65_RS20845	COG1506	peptidase
B7L65_RS20855	COG2409	Drug exporters of the RND superfamily
B7L65_RS21025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B7L65_RS21045	COG3318	Belongs to the UPF0149 family
B7L65_RS21045	COG3012	SEC-C Motif Domain Protein
B7L65_RS21080	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B7L65_RS21090	COG4456	Virulence-associated protein
B7L65_RS21125	COG0784	Response regulator, receiver
B7L65_RS21125	COG4191	Histidine kinase
B7L65_RS21255	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B7L65_RS21285	COG2022	thiamine diphosphate biosynthetic process
B7L65_RS21295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B7L65_RS21300	COG0471	metal ion transport
B7L65_RS21300	COG3273	potassium ion transport
B7L65_RS21325	COG1970	mechanosensitive ion channel activity
B7L65_RS21345	COG3250	beta-galactosidase activity
B7L65_RS21350	COG4948	Mandelate Racemase Muconate Lactonizing
B7L65_RS21365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L65_RS21375	COG0308	aminopeptidase N
B7L65_RS21410	COG0435	Glutathione S-transferase
B7L65_RS21420	COG4221	oxidoreductase activity
B7L65_RS21435	COG4221	oxidoreductase activity
B7L65_RS21490	COG1802	Transcriptional regulator
B7L65_RS21500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B7L65_RS21525	COG3052	prosthetic group binding
B7L65_RS21555	COG2353	YceI-like domain
B7L65_RS21560	COG0778	Nitroreductase
B7L65_RS21580	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B7L65_RS21585	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B7L65_RS21595	COG3386	PFAM SMP-30 Gluconolaconase
B7L65_RS21610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B7L65_RS21625	COG0459	protein refolding
B7L65_RS21640	COG2356	endonuclease I
B7L65_RS21645	COG0300	oxidoreductase activity
B7L65_RS21675	COG1324	tolerance protein
B7L65_RS21685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B7L65_RS21690	COG0511	ligase activity, forming carbon-carbon bonds
B7L65_RS21700	COG0439	Biotin carboxylase
B7L65_RS21730	COG2264	protein methyltransferase activity
B7L65_RS21750	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B7L65_RS21755	COG4589	Belongs to the CDS family
B7L65_RS21780	COG0671	phosphoesterase, PA-phosphatase related
B7L65_RS21780	COG2453	phosphatase
B7L65_RS21785	COG2267	carboxylic ester hydrolase activity
B7L65_RS21790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B7L65_RS21795	COG0138	bifunctional purine biosynthesis protein purh
B7L65_RS21805	COG0151	Belongs to the GarS family
B7L65_RS21815	COG1289	transmembrane transporter activity
B7L65_RS21820	COG2814	Major facilitator Superfamily
B7L65_RS21825	COG0583	DNA-binding transcription factor activity
B7L65_RS21830	COG2814	Major facilitator Superfamily
B7L65_RS21850	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B7L65_RS21870	COG0316	Belongs to the HesB IscA family
B7L65_RS21910	COG1051	belongs to the nudix hydrolase family
B7L65_RS21925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B7L65_RS21935	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B7L65_RS21945	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B7L65_RS21950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L65_RS21960	COG0134	indole-3-glycerol-phosphate synthase activity
B7L65_RS21965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B7L65_RS21990	COG1597	lipid kinase activity
B7L65_RS22010	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B7L65_RS22015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B7L65_RS22035	COG3179	chitinase
B7L65_RS22055	COG2111	Na H antiporter
B7L65_RS22055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B7L65_RS22060	COG1006	Multisubunit Na H antiporter MnhC subunit
B7L65_RS22065	COG0651	ATP synthesis coupled electron transport
B7L65_RS22075	COG2212	antiporter activity
B7L65_RS22080	COG1320	monovalent cation:proton antiporter activity
B7L65_RS22100	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B7L65_RS22125	COG3104	oligopeptide transport
B7L65_RS22130	COG3483	tryptophan 2,3-dioxygenase activity
B7L65_RS22140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B7L65_RS22160	COG0513	Belongs to the DEAD box helicase family
B7L65_RS22170	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS22175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L65_RS22210	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS22215	COG0702	epimerase
B7L65_RS22240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B7L65_RS22245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B7L65_RS22250	COG0297	glycogen (starch) synthase activity
B7L65_RS22260	COG2354	Protein conserved in bacteria
B7L65_RS22275	COG1368	sulfuric ester hydrolase activity
B7L65_RS22280	COG1511	domain protein
B7L65_RS22280	COG3264	Mechanosensitive ion channel
B7L65_RS22350	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B7L65_RS22445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B7L65_RS22450	COG1040	competence protein
B7L65_RS22455	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B7L65_RS22460	COG0156	8-amino-7-oxononanoate synthase activity
B7L65_RS22470	COG2267	carboxylic ester hydrolase activity
B7L65_RS22500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B7L65_RS22510	COG0445	tRNA wobble uridine modification
B7L65_RS22520	COG0657	acetylesterase activity
B7L65_RS22530	COG1414	Transcriptional regulator
B7L65_RS22540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B7L65_RS22545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L65_RS22555	COG3485	protocatechuate 3,4-dioxygenase
B7L65_RS22560	COG3485	protocatechuate 3,4-dioxygenase
B7L65_RS22570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B7L65_RS22575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B7L65_RS22600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B7L65_RS22605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B7L65_RS22660	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B7L65_RS22675	COG0129	dihydroxy-acid dehydratase activity
B7L65_RS22725	COG1733	regulation of RNA biosynthetic process
B7L65_RS22730	COG0702	epimerase
B7L65_RS22765	COG0583	DNA-binding transcription factor activity
B7L65_RS22770	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L65_RS22775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B7L65_RS22795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L65_RS22800	COG2205	protein histidine kinase activity
B7L65_RS22805	COG0745	RESPONSE REGULATOR receiver
B7L65_RS22825	COG1902	pentaerythritol trinitrate reductase activity
B7L65_RS22830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B7L65_RS22835	COG2267	carboxylic ester hydrolase activity
B7L65_RS22845	COG2814	Major facilitator Superfamily
B7L65_RS22850	COG0583	DNA-binding transcription factor activity
B7L65_RS22865	COG0084	hydrolase, TatD family'
B7L65_RS22890	COG2252	PERMEase
B7L65_RS22900	COG1957	nucleoside hydrolase
B7L65_RS22935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B7L65_RS22955	COG2072	flavoprotein involved in K transport
B7L65_RS22960	COG2351	hydroxyisourate hydrolase activity
B7L65_RS22965	COG4807	Protein conserved in bacteria
B7L65_RS22975	COG1643	Atp-dependent helicase
B7L65_RS22990	COG1187	pseudouridine synthase activity
B7L65_RS23005	COG2130	NADP-dependent
B7L65_RS23035	COG1764	response to oxidative stress
B7L65_RS23040	COG1846	Transcriptional regulator
B7L65_RS23045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B7L65_RS23055	COG0697	spore germination
B7L65_RS23065	COG0523	cobalamin synthesis protein
B7L65_RS23125	COG1960	acyl-CoA dehydrogenase activity
B7L65_RS23130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B7L65_RS23135	COG4770	biotin carboxylase activity
B7L65_RS23170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B7L65_RS23175	COG0583	DNA-binding transcription factor activity
B7L65_RS23180	COG0475	glutathione-regulated potassium exporter activity
B7L65_RS23210	COG0339	signal peptide processing
B7L65_RS23235	COG0564	pseudouridine synthase activity
B7L65_RS23245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B7L65_RS23260	COG1181	Belongs to the D-alanine--D-alanine ligase family
B7L65_RS23275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L65_RS23280	COG0318	PFAM AMP-dependent synthetase and ligase
B7L65_RS23285	COG0727	PFAM Uncharacterised protein family (UPF0153)
B7L65_RS23290	COG0596	Alpha beta hydrolase
B7L65_RS23310	COG3177	Filamentation induced by cAMP protein fic
B7L65_RS23315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L65_RS23330	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B7L65_RS23355	COG2205	protein histidine kinase activity
B7L65_RS23360	COG0028	Belongs to the TPP enzyme family
B7L65_RS23375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B7L65_RS23380	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B7L65_RS23385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B7L65_RS23420	COG0183	Belongs to the thiolase family
B7L65_RS23435	COG2032	superoxide dismutase activity
B7L65_RS23440	COG2032	superoxide dismutase activity
B7L65_RS23455	COG2204	response regulator
B7L65_RS23460	COG3852	Histidine kinase
B7L65_RS23465	COG0004	ammonium transporteR
B7L65_RS23470	COG0347	Belongs to the P(II) protein family
B7L65_RS23475	COG0174	glutamine synthetase
B7L65_RS23480	COG1968	undecaprenyl-diphosphatase activity
B7L65_RS23530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L65_RS23540	COG2062	phosphohistidine phosphatase, SixA
B7L65_RS23545	COG0489	protein tyrosine kinase activity
B7L65_RS23570	COG1396	sequence-specific DNA binding
B7L65_RS23590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B7L65_RS23605	COG1125	glycine betaine transport
B7L65_RS23620	COG1119	ATPase activity
B7L65_RS23630	COG1752	Esterase of the alpha-beta hydrolase superfamily
B7L65_RS23640	COG1522	sequence-specific DNA binding
B7L65_RS23645	COG3186	Phenylalanine-4-hydroxylase
B7L65_RS23660	COG2755	lipolytic protein G-D-S-L family
B7L65_RS23670	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS23675	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B7L65_RS23685	COG1609	Transcriptional regulator
B7L65_RS23690	COG3507	Belongs to the glycosyl hydrolase 43 family
B7L65_RS23705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B7L65_RS23715	COG2755	lipolytic protein G-D-S-L family
B7L65_RS23715	COG0657	acetylesterase activity
B7L65_RS23735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B7L65_RS23740	COG0366	Alpha amylase catalytic
B7L65_RS23745	COG0366	Alpha amylase catalytic
B7L65_RS23835	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B7L65_RS23840	COG3710	Transcriptional regulator
B7L65_RS23860	COG2197	response regulator
B7L65_RS23865	COG4585	Histidine kinase
B7L65_RS23880	COG1304	FMN binding
B7L65_RS23905	COG1012	belongs to the aldehyde dehydrogenase family
B7L65_RS23910	COG0662	Cupin 2, conserved barrel domain protein
B7L65_RS23920	COG4772	TonB-dependent receptor
B7L65_RS23930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B7L65_RS23960	COG0714	Associated with various cellular activities
B7L65_RS24000	COG0477	Major facilitator Superfamily
B7L65_RS24010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7L65_RS24060	COG3237	CsbD-like
B7L65_RS24135	COG2249	NAD(P)H dehydrogenase (quinone) activity
B7L65_RS24160	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_RS24165	COG0300	oxidoreductase activity
B7L65_RS24185	COG1272	protein, Hemolysin III
B7L65_RS24190	COG1205	dead DEAH box helicase
B7L65_RS24190	COG1111	helicase
B7L65_RS24285	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B7L65_RS24315	COG1132	(ABC) transporter
B7L65_RS24340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L65_RS24350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L65_RS24350	COG0551	DNA topoisomerase type I activity
B7L65_RS24365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B7L65_RS24430	COG0305	Participates in initiation and elongation during chromosome replication
B7L65_RS24535	COG4974	Belongs to the 'phage' integrase family
B7L65_RS24950	COG1674	ftsk spoiiie
B7L65_RS25005	COG2801	Transposase and inactivated derivatives
B7L65_RS25105	COG0489	protein tyrosine kinase activity
B7L65_RS25210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B7L65_RS25230	COG3012	SEC-C Motif Domain Protein
B7L65_RS25230	COG3318	Belongs to the UPF0149 family
B7L65_RS25250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L65_RS25285	COG3846	protein secretion by the type IV secretion system
B7L65_RS25295	COG3451	type IV secretory pathway VirB4
B7L65_RS25305	COG3838	Conjugal transfer protein Trbc
B7L65_RS25310	COG4962	Type ii secretion system protein e