locus-tag	class	description
B7L66_RS00005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B7L66_RS00020	COG0583	DNA-binding transcription factor activity
B7L66_RS00030	COG1051	belongs to the nudix hydrolase family
B7L66_RS00030	COG1056	cytidyltransferase-related domain
B7L66_RS00065	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B7L66_RS00070	COG0673	inositol 2-dehydrogenase activity
B7L66_RS00075	COG2823	Periplasmic or secreted lipoprotein
B7L66_RS00080	COG4251	negative regulation of phosphorylation
B7L66_RS00085	COG0784	Response regulator, receiver
B7L66_RS00090	COG4191	Histidine kinase
B7L66_RS00095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B7L66_RS00155	COG1459	type II secretion system
B7L66_RS00205	COG3250	beta-galactosidase activity
B7L66_RS00220	COG2188	Transcriptional regulator
B7L66_RS00230	COG1609	Transcriptional regulator
B7L66_RS00235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B7L66_RS00240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B7L66_RS00250	COG0617	tRNA 3'-terminal CCA addition
B7L66_RS00255	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B7L66_RS00260	COG1012	belongs to the aldehyde dehydrogenase family
B7L66_RS00265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B7L66_RS00280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B7L66_RS00295	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B7L66_RS00300	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B7L66_RS00320	COG2205	protein histidine kinase activity
B7L66_RS00350	COG3791	Glutathione-dependent formaldehyde-activating
B7L66_RS00365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L66_RS00375	COG0697	spore germination
B7L66_RS00385	COG0488	(ABC) transporter
B7L66_RS00395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B7L66_RS00400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B7L66_RS00410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L66_RS00410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L66_RS00430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B7L66_RS00435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B7L66_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B7L66_RS00465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B7L66_RS00470	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B7L66_RS00475	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B7L66_RS00480	COG2205	protein histidine kinase activity
B7L66_RS00485	COG0745	RESPONSE REGULATOR receiver
B7L66_RS00510	COG0277	FAD linked oxidase domain protein
B7L66_RS00515	COG1988	membrane-bound metal-dependent
B7L66_RS00520	COG0792	nuclease activity
B7L66_RS00555	COG0275	rRNA processing
B7L66_RS00560	COG3116	cell division
B7L66_RS00570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B7L66_RS00575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B7L66_RS00580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7L66_RS00590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B7L66_RS00595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B7L66_RS00600	COG1181	Belongs to the D-alanine--D-alanine ligase family
B7L66_RS00605	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B7L66_RS00620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B7L66_RS00630	COG0739	heme binding
B7L66_RS00635	COG0653	protein targeting
B7L66_RS00640	COG0494	nUDIX hydrolase
B7L66_RS00650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B7L66_RS00665	COG0604	alcohol dehydrogenase
B7L66_RS00665	COG3321	synthase
B7L66_RS00665	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS00695	COG0366	Alpha amylase catalytic
B7L66_RS00730	COG2226	methyltransferase
B7L66_RS00735	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B7L66_RS00745	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B7L66_RS00790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B7L66_RS00800	COG4106	trans-aconitate 2-methyltransferase activity
B7L66_RS00805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B7L66_RS00815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L66_RS00820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B7L66_RS00830	COG0667	Aldo Keto reductase
B7L66_RS00840	COG4771	TonB-dependent receptor
B7L66_RS00860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L66_RS00865	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B7L66_RS00875	COG2175	clavaminate synthase activity
B7L66_RS00880	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B7L66_RS00885	COG4181	ATPase activity
B7L66_RS00900	COG0642	Histidine kinase
B7L66_RS00915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B7L66_RS00935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B7L66_RS00940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B7L66_RS00955	COG3829	transcription factor binding
B7L66_RS00965	COG1116	anion transmembrane transporter activity
B7L66_RS00970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L66_RS00980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L66_RS00985	COG0431	NADPH-dependent FMN reductase
B7L66_RS01010	COG0747	negative chemotaxis
B7L66_RS01020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7L66_RS01030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B7L66_RS01035	COG2967	ApaG domain
B7L66_RS01040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B7L66_RS01045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B7L66_RS01050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L66_RS01055	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B7L66_RS01070	COG0123	including yeast histone deacetylase and acetoin utilization protein
B7L66_RS01075	COG2096	Adenosyltransferase
B7L66_RS01090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L66_RS01095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L66_RS01125	COG3384	dioxygenase
B7L66_RS01130	COG0583	DNA-binding transcription factor activity
B7L66_RS01135	COG0318	PFAM AMP-dependent synthetase and ligase
B7L66_RS01145	COG1024	Enoyl-CoA hydratase
B7L66_RS01165	COG3386	PFAM SMP-30 Gluconolaconase
B7L66_RS01180	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B7L66_RS01205	COG0697	spore germination
B7L66_RS01215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L66_RS01235	COG2205	protein histidine kinase activity
B7L66_RS01235	COG0784	Response regulator, receiver
B7L66_RS01235	COG5002	protein histidine kinase activity
B7L66_RS01240	COG2197	response regulator
B7L66_RS01250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B7L66_RS01260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B7L66_RS01265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L66_RS01275	COG0583	DNA-binding transcription factor activity
B7L66_RS01280	COG3634	alkyl hydroperoxide reductase activity
B7L66_RS01290	COG2890	protein-(glutamine-N5) methyltransferase activity
B7L66_RS01310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7L66_RS01310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7L66_RS01340	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B7L66_RS01365	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B7L66_RS01380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B7L66_RS01385	COG1404	Belongs to the peptidase S8 family
B7L66_RS01395	COG1404	Belongs to the peptidase S8 family
B7L66_RS01400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B7L66_RS01425	COG1295	ribonuclease BN
B7L66_RS01430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7L66_RS01450	COG0521	Mo-molybdopterin cofactor biosynthetic process
B7L66_RS01460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B7L66_RS01475	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B7L66_RS01480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B7L66_RS01490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B7L66_RS01495	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B7L66_RS01500	COG0193	aminoacyl-tRNA hydrolase activity
B7L66_RS01505	COG0012	GTP binding
B7L66_RS01525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B7L66_RS01540	COG0250	Participates in transcription elongation, termination and antitermination
B7L66_RS01545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B7L66_RS01550	COG0081	regulation of translation
B7L66_RS01555	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B7L66_RS01560	COG0222	ribosome binding
B7L66_RS01565	COG0085	RNA polymerase activity
B7L66_RS01570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B7L66_RS01575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B7L66_RS01580	COG0049	tRNA binding
B7L66_RS01585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B7L66_RS01590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B7L66_RS01595	COG0051	transcription antitermination factor activity, RNA binding
B7L66_RS01600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B7L66_RS01605	COG0088	Forms part of the polypeptide exit tunnel
B7L66_RS01610	COG0089	rRNA binding
B7L66_RS01615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B7L66_RS01620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B7L66_RS01630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B7L66_RS01635	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B7L66_RS01640	COG0255	Belongs to the universal ribosomal protein uL29 family
B7L66_RS01645	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B7L66_RS01655	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B7L66_RS01660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B7L66_RS01670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B7L66_RS01675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B7L66_RS01680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B7L66_RS01690	COG1841	ribosomal large subunit assembly
B7L66_RS01695	COG0200	Binds to the 23S rRNA
B7L66_RS01700	COG0201	protein transport
B7L66_RS01725	COG0203	ribosomal protein L17
B7L66_RS01730	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B7L66_RS01750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B7L66_RS01760	COG0154	amidase activity
B7L66_RS01770	COG1217	gtp-binding protein TYPA
B7L66_RS01775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B7L66_RS01780	COG0039	L-malate dehydrogenase activity
B7L66_RS01785	COG0625	glutathione transferase activity
B7L66_RS01805	COG0446	pyridine nucleotide-disulphide oxidoreductase
B7L66_RS01805	COG1902	pentaerythritol trinitrate reductase activity
B7L66_RS01810	COG0604	alcohol dehydrogenase
B7L66_RS01840	COG0156	8-amino-7-oxononanoate synthase activity
B7L66_RS01845	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B7L66_RS01850	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B7L66_RS01855	COG4208	sulfate ABC transporter
B7L66_RS01860	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B7L66_RS01870	COG1063	alcohol dehydrogenase
B7L66_RS01905	COG0285	dihydrofolate synthase activity
B7L66_RS01925	COG2833	Protein of unknown function (DUF455)
B7L66_RS01935	COG3291	Pkd domain containing protein
B7L66_RS01945	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L66_RS01950	COG0671	phosphoesterase, PA-phosphatase related
B7L66_RS01955	COG0438	transferase activity, transferring glycosyl groups
B7L66_RS01965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B7L66_RS01980	COG4783	chaperone-mediated protein folding
B7L66_RS01995	COG0473	3-isopropylmalate dehydrogenase activity
B7L66_RS02150	COG0544	peptidyl-prolyl cis-trans isomerase activity
B7L66_RS02160	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B7L66_RS02190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L66_RS02200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L66_RS02210	COG0328	RNA-DNA hybrid ribonuclease activity
B7L66_RS02215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B7L66_RS02220	COG0631	protein serine/threonine phosphatase activity
B7L66_RS02235	COG0859	PFAM glycosyl transferase family 9
B7L66_RS02240	COG3642	lipopolysaccharide core region biosynthetic process
B7L66_RS02245	COG1234	tRNA 3'-trailer cleavage
B7L66_RS02250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B7L66_RS02260	COG0315	cyclic pyranopterin monophosphate synthase activity
B7L66_RS02265	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B7L66_RS02270	COG0314	molybdopterin synthase activity
B7L66_RS02320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B7L66_RS02325	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B7L66_RS02330	COG0537	adenosine 5'-monophosphoramidase activity
B7L66_RS02350	COG0714	Associated with various cellular activities
B7L66_RS02375	COG0424	maF-like protein
B7L66_RS02380	COG1399	metal-binding, possibly nucleic acid-binding protein
B7L66_RS02385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B7L66_RS02390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L66_RS02405	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS02420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B7L66_RS02425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B7L66_RS02450	COG3829	transcription factor binding
B7L66_RS02470	COG3609	addiction module antidote protein, CC2985 family
B7L66_RS02505	COG2373	Large extracellular alpha-helical protein
B7L66_RS02525	COG4953	penicillin-binding protein 1C
B7L66_RS02535	COG0678	peroxiredoxin activity
B7L66_RS02560	COG0330	HflC and HflK could
B7L66_RS02565	COG0330	HflC and HflK could
B7L66_RS02575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B7L66_RS02580	COG0308	aminopeptidase N
B7L66_RS02585	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS02590	COG1309	transcriptional regulator
B7L66_RS02635	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B7L66_RS02670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B7L66_RS02680	COG3387	PFAM Glycoside hydrolase 15-related
B7L66_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS02725	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B7L66_RS02730	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B7L66_RS02735	COG2080	2 iron, 2 sulfur cluster binding
B7L66_RS02770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B7L66_RS02785	COG0587	DNA-directed DNA polymerase activity
B7L66_RS02805	COG1297	OPT oligopeptide transporter protein
B7L66_RS02820	COG0823	Involved in the tonB-independent uptake of proteins
B7L66_RS02820	COG1506	peptidase
B7L66_RS02835	COG2207	Transcriptional regulator
B7L66_RS02835	COG1917	Cupin 2, conserved barrel domain protein
B7L66_RS02850	COG0753	catalase activity
B7L66_RS02855	COG0656	L-ascorbic acid biosynthetic process
B7L66_RS02865	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B7L66_RS02865	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B7L66_RS02870	COG2814	Major facilitator Superfamily
B7L66_RS02885	COG2194	sulfuric ester hydrolase activity
B7L66_RS02900	COG0745	RESPONSE REGULATOR receiver
B7L66_RS02905	COG0642	Histidine kinase
B7L66_RS02915	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B7L66_RS02920	COG2894	cell division
B7L66_RS02925	COG0850	regulation of cytokinetic process
B7L66_RS02940	COG4585	Histidine kinase
B7L66_RS02945	COG2197	response regulator
B7L66_RS02960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B7L66_RS02990	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B7L66_RS03000	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B7L66_RS03020	COG1946	Acyl-CoA thioesterase
B7L66_RS03035	COG0824	Thioesterase
B7L66_RS03040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B7L66_RS03045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B7L66_RS03050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B7L66_RS03055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B7L66_RS03060	COG0268	Binds directly to 16S ribosomal RNA
B7L66_RS03070	COG0196	riboflavin kinase activity
B7L66_RS03075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B7L66_RS03080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B7L66_RS03085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B7L66_RS03100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B7L66_RS03105	COG1845	cytochrome c oxidase, subunit III
B7L66_RS03110	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B7L66_RS03125	COG3152	Membrane
B7L66_RS03135	COG2207	Transcriptional regulator
B7L66_RS03140	COG0326	Molecular chaperone. Has ATPase activity
B7L66_RS03155	COG1366	Belongs to the anti-sigma-factor antagonist family
B7L66_RS03160	COG1366	Belongs to the anti-sigma-factor antagonist family
B7L66_RS03165	COG2172	sigma factor antagonist activity
B7L66_RS03190	COG4771	TonB-dependent receptor
B7L66_RS03200	COG5507	3-demethylubiquinone-9 3-methyltransferase
B7L66_RS03205	COG2205	protein histidine kinase activity
B7L66_RS03215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B7L66_RS03220	COG3437	response regulator, receiver
B7L66_RS03220	COG3850	Histidine kinase
B7L66_RS03220	COG4999	Histidine kinase
B7L66_RS03220	COG2205	protein histidine kinase activity
B7L66_RS03225	COG0784	Response regulator, receiver
B7L66_RS03225	COG4191	Histidine kinase
B7L66_RS03250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B7L66_RS03260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B7L66_RS03270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B7L66_RS03275	COG0228	four-way junction DNA binding
B7L66_RS03280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B7L66_RS03285	COG0336	Belongs to the RNA methyltransferase TrmD family
B7L66_RS03290	COG0335	large ribosomal subunit rRNA binding
B7L66_RS03295	COG0534	Mate efflux family protein
B7L66_RS03315	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B7L66_RS03325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B7L66_RS03335	COG3209	COG3209 Rhs family protein
B7L66_RS03360	COG3250	beta-galactosidase activity
B7L66_RS03365	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B7L66_RS03385	COG1960	acyl-CoA dehydrogenase activity
B7L66_RS03390	COG1024	Enoyl-CoA hydratase
B7L66_RS03410	COG1250	3-hydroxyacyl-CoA dehydrogenase
B7L66_RS03410	COG1024	Enoyl-CoA hydratase
B7L66_RS03425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7L66_RS03430	COG0481	GTPase activity
B7L66_RS03445	COG0571	ribonuclease III activity
B7L66_RS03450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B7L66_RS03455	COG1381	Involved in DNA repair and RecF pathway recombination
B7L66_RS03465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B7L66_RS03470	COG2954	triphosphatase activity
B7L66_RS03475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B7L66_RS03480	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
B7L66_RS03485	COG3046	protein related to deoxyribodipyrimidine photolyase
B7L66_RS03490	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L66_RS03495	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B7L66_RS03500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B7L66_RS03505	COG1278	Cold shock
B7L66_RS03510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L66_RS03520	COG1201	RNA secondary structure unwinding
B7L66_RS03525	COG1793	dna ligase
B7L66_RS03535	COG1793	dna ligase
B7L66_RS03535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B7L66_RS03570	COG0183	Belongs to the thiolase family
B7L66_RS03595	COG1451	nucleotide metabolic process
B7L66_RS03600	COG5487	UPF0391 membrane protein
B7L66_RS03610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B7L66_RS03625	COG1077	Cell shape determining protein MreB Mrl
B7L66_RS03630	COG1047	Peptidyl-prolyl cis-trans
B7L66_RS03640	COG2824	Alkylphosphonate utilization operon protein PhnA
B7L66_RS03650	COG1902	pentaerythritol trinitrate reductase activity
B7L66_RS03655	COG2814	Major facilitator Superfamily
B7L66_RS03690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B7L66_RS03690	COG0392	lysyltransferase activity
B7L66_RS03700	COG0251	oxidation-reduction process
B7L66_RS03705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L66_RS03720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L66_RS03745	COG1595	DNA-templated transcription, initiation
B7L66_RS03765	COG2878	Part of a membrane complex involved in electron transport
B7L66_RS03775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L66_RS03775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L66_RS03790	COG1131	(ABC) transporter
B7L66_RS03795	COG0346	lactoylglutathione lyase activity
B7L66_RS03800	COG0833	amino acid
B7L66_RS03805	COG2040	homocysteine
B7L66_RS03815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B7L66_RS03835	COG1695	Transcriptional regulator
B7L66_RS03855	COG1981	membrane
B7L66_RS03870	COG0825	malonyl-CoA metabolic process
B7L66_RS03880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B7L66_RS03885	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L66_RS03890	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L66_RS03895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L66_RS03900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L66_RS03915	COG0750	zinc metalloprotease
B7L66_RS03920	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B7L66_RS03925	COG0575	Belongs to the CDS family
B7L66_RS03930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B7L66_RS03935	COG0233	cytoplasmic translational termination
B7L66_RS03940	COG0528	UMP kinase activity
B7L66_RS03950	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B7L66_RS03955	COG0052	Belongs to the universal ribosomal protein uS2 family
B7L66_RS03995	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B7L66_RS04005	COG1393	Belongs to the ArsC family
B7L66_RS04010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B7L66_RS04015	COG0367	asparagine synthase
B7L66_RS04025	COG4774	siderophore transport
B7L66_RS04045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B7L66_RS04075	COG1566	PFAM secretion protein HlyD family protein
B7L66_RS04080	COG2814	Major facilitator Superfamily
B7L66_RS04130	COG0339	signal peptide processing
B7L66_RS04140	COG0386	Belongs to the glutathione peroxidase family
B7L66_RS04195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B7L66_RS04200	COG0084	hydrolase, TatD family'
B7L66_RS04215	COG1960	acyl-CoA dehydrogenase activity
B7L66_RS04235	COG0367	asparagine synthase
B7L66_RS04245	COG0305	Participates in initiation and elongation during chromosome replication
B7L66_RS04250	COG0415	Belongs to the DNA photolyase family
B7L66_RS04270	COG0583	DNA-binding transcription factor activity
B7L66_RS04315	COG3706	GGDEF domain
B7L66_RS04370	COG0237	dephospho-CoA kinase activity
B7L66_RS04375	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B7L66_RS04410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L66_RS04425	COG0045	succinate-CoA ligase (ADP-forming) activity
B7L66_RS04430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B7L66_RS04455	COG2369	cell adhesion
B7L66_RS04475	COG4644	lycopene metabolic process
B7L66_RS04480	COG2951	lytic endotransglycosylase activity
B7L66_RS04505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B7L66_RS04505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B7L66_RS04515	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L66_RS04520	COG0564	pseudouridine synthase activity
B7L66_RS04535	COG3011	Protein conserved in bacteria
B7L66_RS04540	COG0840	transmembrane signaling receptor activity
B7L66_RS04560	COG3387	PFAM Glycoside hydrolase 15-related
B7L66_RS04565	COG1877	trehalose-phosphatase activity
B7L66_RS04605	COG2827	Endonuclease containing a URI domain
B7L66_RS04610	COG4771	TonB-dependent receptor
B7L66_RS04615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L66_RS04620	COG0667	Aldo Keto reductase
B7L66_RS04625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B7L66_RS04630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L66_RS04635	COG1116	anion transmembrane transporter activity
B7L66_RS04640	COG0542	response to heat
B7L66_RS04645	COG4206	TonB-dependent receptor
B7L66_RS04665	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B7L66_RS04675	COG1492	cobalamin metabolic process
B7L66_RS04685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B7L66_RS04720	COG0019	diaminopimelate decarboxylase activity
B7L66_RS04735	COG4264	IucA IucC family
B7L66_RS04745	COG4772	TonB-dependent receptor
B7L66_RS04770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B7L66_RS04770	COG4651	solute:proton antiporter activity
B7L66_RS04810	COG0488	(ABC) transporter
B7L66_RS04855	COG0477	Major facilitator Superfamily
B7L66_RS04870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B7L66_RS04885	COG0217	transcriptional regulatory protein
B7L66_RS04890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B7L66_RS04895	COG0632	four-way junction helicase activity
B7L66_RS04900	COG3158	transport of potassium into the cell
B7L66_RS04910	COG2255	four-way junction helicase activity
B7L66_RS04915	COG0824	Thioesterase
B7L66_RS04925	COG0848	biopolymer transport protein
B7L66_RS04935	COG0823	Involved in the tonB-independent uptake of proteins
B7L66_RS04940	COG2885	chlorophyll binding
B7L66_RS04950	COG0602	queuosine metabolic process
B7L66_RS04960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B7L66_RS04965	COG3920	Histidine kinase
B7L66_RS04985	COG0840	transmembrane signaling receptor activity
B7L66_RS05020	COG0514	ATP-dependent DNA helicase (RecQ)
B7L66_RS05030	COG0783	Belongs to the Dps family
B7L66_RS05035	COG1643	Atp-dependent helicase
B7L66_RS05050	COG0837	glucose binding
B7L66_RS05070	COG0535	radical SAM domain protein
B7L66_RS05075	COG0535	radical SAM domain protein
B7L66_RS05080	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
B7L66_RS05085	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B7L66_RS05095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B7L66_RS05120	COG1215	transferase activity, transferring glycosyl groups
B7L66_RS05125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B7L66_RS05135	COG1199	ATP-dependent helicase activity
B7L66_RS05145	COG1397	ADP-ribosylglycohydrolase
B7L66_RS05155	COG0189	ligase activity
B7L66_RS05170	COG0835	chemotaxis
B7L66_RS05175	COG0840	transmembrane signaling receptor activity
B7L66_RS05180	COG0643	Histidine kinase
B7L66_RS05180	COG0784	Response regulator, receiver
B7L66_RS05180	COG2198	Histidine kinase
B7L66_RS05215	COG1446	asparaginase
B7L66_RS05220	COG3142	Participates in the control of copper homeostasis
B7L66_RS05260	COG3537	Alpha-1,2-mannosidase
B7L66_RS05270	COG1486	melibiose metabolic process
B7L66_RS05280	COG0531	amino acid
B7L66_RS05295	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L66_RS05310	COG3858	chitin binding
B7L66_RS05310	COG1388	LysM domain
B7L66_RS05325	COG0837	glucose binding
B7L66_RS05330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B7L66_RS05340	COG0494	nUDIX hydrolase
B7L66_RS05350	COG3956	TIGRFAM MazG family protein
B7L66_RS05355	COG1742	UPF0060 membrane protein
B7L66_RS05360	COG0330	HflC and HflK could
B7L66_RS05370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B7L66_RS05375	COG0509	glycine decarboxylation via glycine cleavage system
B7L66_RS05400	COG1960	acyl-CoA dehydrogenase activity
B7L66_RS05410	COG1309	transcriptional regulator
B7L66_RS05420	COG4771	TonB-dependent receptor
B7L66_RS05430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B7L66_RS05435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B7L66_RS05440	COG0463	Glycosyl transferase, family 2
B7L66_RS05445	COG0517	IMP dehydrogenase activity
B7L66_RS05445	COG0516	GMP reductase activity
B7L66_RS05455	COG1272	protein, Hemolysin III
B7L66_RS05460	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B7L66_RS05465	COG0739	heme binding
B7L66_RS05470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L66_RS05475	COG0626	cystathionine gamma-synthase activity
B7L66_RS05480	COG0460	homoserine dehydrogenase
B7L66_RS05480	COG0527	aspartate kinase activity
B7L66_RS05495	COG1760	l-serine dehydratase
B7L66_RS05515	COG2353	YceI-like domain
B7L66_RS05520	COG2205	protein histidine kinase activity
B7L66_RS05520	COG2198	Histidine kinase
B7L66_RS05520	COG0784	Response regulator, receiver
B7L66_RS05540	COG0477	Major facilitator Superfamily
B7L66_RS05615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B7L66_RS05625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B7L66_RS05630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B7L66_RS05635	COG0259	pyridoxamine-phosphate oxidase activity
B7L66_RS05645	COG1842	Phage shock protein A
B7L66_RS05670	COG0754	glutathionylspermidine amidase activity
B7L66_RS05680	COG2814	Major facilitator Superfamily
B7L66_RS05730	COG1234	tRNA 3'-trailer cleavage
B7L66_RS05765	COG0531	amino acid
B7L66_RS05770	COG2197	response regulator
B7L66_RS05800	COG1113	amino acid transport
B7L66_RS05810	COG1271	oxidase subunit
B7L66_RS05815	COG1294	oxidase, subunit
B7L66_RS05830	COG2239	Acts as a magnesium transporter
B7L66_RS05840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L66_RS05845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L66_RS05855	COG1660	Displays ATPase and GTPase activities
B7L66_RS05860	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B7L66_RS05865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L66_RS05880	COG1137	ATPase activity
B7L66_RS05885	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B7L66_RS05895	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B7L66_RS05905	COG0271	Belongs to the BolA IbaG family
B7L66_RS05910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B7L66_RS05930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B7L66_RS05940	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B7L66_RS05950	COG0628	permease
B7L66_RS05960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B7L66_RS05965	COG3178	'Phosphotransferase
B7L66_RS05975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B7L66_RS05980	COG1555	photosystem II stabilization
B7L66_RS05995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B7L66_RS06000	COG1477	protein flavinylation
B7L66_RS06025	COG3128	pkhd-type hydroxylase
B7L66_RS06030	COG4774	siderophore transport
B7L66_RS06035	COG2146	nitrite reductase [NAD(P)H] activity
B7L66_RS06045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B7L66_RS06050	COG0719	Fe-S assembly protein
B7L66_RS06055	COG0396	ATPase activity
B7L66_RS06060	COG0719	Fe-S assembly protein
B7L66_RS06065	COG1959	2 iron, 2 sulfur cluster binding
B7L66_RS06075	COG0693	protein deglycase activity
B7L66_RS06095	COG0739	heme binding
B7L66_RS06110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B7L66_RS06125	COG5297	Belongs to the glycosyl hydrolase family 6
B7L66_RS06135	COG0519	Catalyzes the synthesis of GMP from XMP
B7L66_RS06145	COG1678	Uncharacterized ACR, COG1678
B7L66_RS06150	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B7L66_RS06155	COG0540	Belongs to the ATCase OTCase family
B7L66_RS06160	COG1764	response to oxidative stress
B7L66_RS06170	COG0384	phenazine biosynthesis protein PhzF
B7L66_RS06175	COG0384	phenazine biosynthesis protein PhzF
B7L66_RS06180	COG0527	aspartate kinase activity
B7L66_RS06195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B7L66_RS06210	COG0142	geranyltranstransferase activity
B7L66_RS06215	COG0629	single-stranded DNA binding
B7L66_RS06220	COG3706	GGDEF domain
B7L66_RS06220	COG2203	Gaf domain
B7L66_RS06220	COG5001	Diguanylate cyclase
B7L66_RS06220	COG4251	negative regulation of phosphorylation
B7L66_RS06235	COG2080	2 iron, 2 sulfur cluster binding
B7L66_RS06240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B7L66_RS06245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B7L66_RS06300	COG2879	small protein
B7L66_RS06305	COG1966	Carbon starvation protein
B7L66_RS06310	COG1741	Belongs to the pirin family
B7L66_RS06325	COG1741	Belongs to the pirin family
B7L66_RS06335	COG1515	deoxyribonuclease V activity
B7L66_RS06340	COG0588	phosphoglycerate mutase activity
B7L66_RS06350	COG3590	peptidase
B7L66_RS06355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L66_RS06360	COG2201	protein-glutamate methylesterase activity
B7L66_RS06365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B7L66_RS06370	COG2202	Pas domain
B7L66_RS06370	COG2199	diguanylate cyclase activity
B7L66_RS06370	COG2200	EAL domain
B7L66_RS06375	COG0835	chemotaxis
B7L66_RS06380	COG0840	transmembrane signaling receptor activity
B7L66_RS06390	COG2198	Histidine kinase
B7L66_RS06390	COG0643	Histidine kinase
B7L66_RS06440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B7L66_RS06450	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B7L66_RS06455	COG0745	RESPONSE REGULATOR receiver
B7L66_RS06460	COG2205	protein histidine kinase activity
B7L66_RS06470	COG4452	Inner membrane protein CreD
B7L66_RS06495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L66_RS06500	COG0735	belongs to the Fur family
B7L66_RS06515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L66_RS06525	COG1309	transcriptional regulator
B7L66_RS06535	COG2207	Transcriptional regulator
B7L66_RS06545	COG0583	DNA-binding transcription factor activity
B7L66_RS06550	COG2814	Major facilitator Superfamily
B7L66_RS06555	COG0667	Aldo Keto reductase
B7L66_RS06675	COG5002	protein histidine kinase activity
B7L66_RS06675	COG5001	Diguanylate cyclase
B7L66_RS06680	COG1187	pseudouridine synthase activity
B7L66_RS06705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B7L66_RS06715	COG0475	glutathione-regulated potassium exporter activity
B7L66_RS06720	COG5000	phosphorelay sensor kinase activity
B7L66_RS06720	COG5002	protein histidine kinase activity
B7L66_RS06725	COG0745	RESPONSE REGULATOR receiver
B7L66_RS06730	COG1538	Outer membrane efflux protein
B7L66_RS06760	COG1132	(ABC) transporter
B7L66_RS06805	COG2155	Conserved Protein
B7L66_RS06830	COG3118	belongs to the thioredoxin family
B7L66_RS06840	COG0495	leucyl-tRNA aminoacylation
B7L66_RS06855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B7L66_RS06870	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B7L66_RS06885	COG2968	Membrane
B7L66_RS06890	COG0424	maF-like protein
B7L66_RS06900	COG3164	Protein of unknown function
B7L66_RS06910	COG0312	modulator of DNA gyrase
B7L66_RS06915	COG3028	Belongs to the UPF0307 family
B7L66_RS06920	COG0312	modulator of DNA gyrase
B7L66_RS06930	COG4104	PAAR repeat-containing protein
B7L66_RS06935	COG0142	geranyltranstransferase activity
B7L66_RS06940	COG1722	exodeoxyribonuclease VII activity
B7L66_RS06945	COG0037	tRNA processing
B7L66_RS06955	COG1785	Belongs to the alkaline phosphatase family
B7L66_RS06960	COG1301	dicarboxylic acid transport
B7L66_RS06965	COG4106	trans-aconitate 2-methyltransferase activity
B7L66_RS06975	COG0791	NLP P60 protein
B7L66_RS06980	COG0791	NLP P60 protein
B7L66_RS06985	COG1047	Peptidyl-prolyl cis-trans
B7L66_RS06990	COG2311	Membrane
B7L66_RS06995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L66_RS07000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L66_RS07020	COG3590	peptidase
B7L66_RS07030	COG3590	peptidase
B7L66_RS07050	COG0489	protein tyrosine kinase activity
B7L66_RS07060	COG0717	Belongs to the dCTP deaminase family
B7L66_RS07085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L66_RS07090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L66_RS07110	COG0494	nUDIX hydrolase
B7L66_RS07115	COG0433	COG0433 Predicted ATPase
B7L66_RS07130	COG0688	phosphatidylethanolamine metabolic process
B7L66_RS07140	COG2890	protein-(glutamine-N5) methyltransferase activity
B7L66_RS07145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B7L66_RS07150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B7L66_RS07155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B7L66_RS07175	COG0101	tRNA pseudouridine synthase activity
B7L66_RS07180	COG0135	phosphoribosylanthranilate isomerase activity
B7L66_RS07190	COG0133	tryptophan synthase activity
B7L66_RS07200	COG0159	tryptophan synthase activity
B7L66_RS07205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B7L66_RS07210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L66_RS07240	COG0300	oxidoreductase activity
B7L66_RS07245	COG0149	triose-phosphate isomerase activity
B7L66_RS07260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L66_RS07265	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L66_RS07270	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L66_RS07275	COG0649	NAD binding
B7L66_RS07280	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B7L66_RS07285	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B7L66_RS07295	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B7L66_RS07300	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L66_RS07325	COG1007	ATP synthesis coupled electron transport
B7L66_RS07335	COG0779	Required for maturation of 30S ribosomal subunits
B7L66_RS07340	COG0195	Participates in both transcription termination and antitermination
B7L66_RS07345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B7L66_RS07350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B7L66_RS07355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B7L66_RS07360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B7L66_RS07365	COG1185	polyribonucleotide nucleotidyltransferase activity
B7L66_RS07405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B7L66_RS07415	COG2095	MarC family integral membrane protein
B7L66_RS07430	COG1611	Belongs to the LOG family
B7L66_RS07435	COG3275	phosphorelay sensor kinase activity
B7L66_RS07475	COG2963	transposase activity
B7L66_RS07565	COG0556	nucleotide-excision repair
B7L66_RS07580	COG3505	Type IV secretory pathway VirD4
B7L66_RS07600	COG2948	multi-organism process
B7L66_RS07620	COG3702	type iv secretory pathway
B7L66_RS07710	COG0366	Alpha amylase catalytic
B7L66_RS07735	COG1082	Xylose isomerase domain protein TIM barrel
B7L66_RS07760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B7L66_RS07765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B7L66_RS07780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B7L66_RS07785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L66_RS07785	COG0072	phenylalanine-tRNA ligase activity
B7L66_RS07835	COG0438	transferase activity, transferring glycosyl groups
B7L66_RS07840	COG0438	transferase activity, transferring glycosyl groups
B7L66_RS07850	COG0438	transferase activity, transferring glycosyl groups
B7L66_RS07875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L66_RS07880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L66_RS07885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L66_RS07905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B7L66_RS07915	COG1960	acyl-CoA dehydrogenase activity
B7L66_RS07930	COG3040	lipid binding
B7L66_RS07945	COG0322	excinuclease ABC activity
B7L66_RS07960	COG0784	Response regulator, receiver
B7L66_RS07960	COG4191	Histidine kinase
B7L66_RS07965	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B7L66_RS07970	COG1194	a g-specific adenine glycosylase
B7L66_RS07980	COG0552	protein localization to endoplasmic reticulum
B7L66_RS07990	COG3938	Belongs to the proline racemase family
B7L66_RS07995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L66_RS08010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L66_RS08020	COG0006	proline dipeptidase activity
B7L66_RS08035	COG0531	amino acid
B7L66_RS08140	COG0326	Molecular chaperone. Has ATPase activity
B7L66_RS08145	COG0742	ribosomal rna small subunit methyltransferase
B7L66_RS08150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B7L66_RS08165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B7L66_RS08170	COG0405	Gamma-glutamyltransferase
B7L66_RS08175	COG3291	Pkd domain containing protein
B7L66_RS08180	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B7L66_RS08225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B7L66_RS08230	COG0343	queuine tRNA-ribosyltransferase activity
B7L66_RS08235	COG1862	Preprotein translocase
B7L66_RS08245	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B7L66_RS08285	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L66_RS08285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L66_RS08290	COG1105	Belongs to the carbohydrate kinase PfkB family
B7L66_RS08295	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L66_RS08295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L66_RS08300	COG1609	Transcriptional regulator
B7L66_RS08305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L66_RS08310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L66_RS08320	COG2902	Dehydrogenase
B7L66_RS08330	COG0477	Major facilitator Superfamily
B7L66_RS08340	COG0784	Response regulator, receiver
B7L66_RS08340	COG2205	protein histidine kinase activity
B7L66_RS08340	COG5002	protein histidine kinase activity
B7L66_RS08345	COG2733	membrane
B7L66_RS08355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B7L66_RS08370	COG2223	nitrite transmembrane transporter activity
B7L66_RS08375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B7L66_RS08380	COG0243	molybdopterin cofactor binding
B7L66_RS08390	COG0477	Major facilitator Superfamily
B7L66_RS08395	COG2703	oxygen carrier activity
B7L66_RS08405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L66_RS08410	COG0174	glutamine synthetase
B7L66_RS08415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B7L66_RS08430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B7L66_RS08450	COG3842	ATPase activity
B7L66_RS08455	COG1176	ABC-type spermidine putrescine transport system, permease component I
B7L66_RS08460	COG1177	transmembrane transport
B7L66_RS08465	COG1012	belongs to the aldehyde dehydrogenase family
B7L66_RS08480	COG4535	Mg2 and Co2 transporter CorC
B7L66_RS08490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B7L66_RS08500	COG1702	phosphate starvation-inducible protein PhoH
B7L66_RS08505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L66_RS08520	COG0741	lytic transglycosylase activity
B7L66_RS08530	COG0723	plastoquinol--plastocyanin reductase activity
B7L66_RS08535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B7L66_RS08540	COG2857	Cytochrome c1
B7L66_RS08545	COG0625	glutathione transferase activity
B7L66_RS08550	COG2969	positive regulation of protein catabolic process
B7L66_RS08570	COG1201	RNA secondary structure unwinding
B7L66_RS08575	COG2094	Belongs to the DNA glycosylase MPG family
B7L66_RS08580	COG0840	transmembrane signaling receptor activity
B7L66_RS08585	COG0835	chemotaxis
B7L66_RS08775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B7L66_RS08785	COG1570	exodeoxyribonuclease VII activity
B7L66_RS08790	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L66_RS08795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B7L66_RS08795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B7L66_RS08800	COG0802	atpase or kinase
B7L66_RS08805	COG0860	N-Acetylmuramoyl-L-alanine amidase
B7L66_RS08810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B7L66_RS08835	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS08840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L66_RS08845	COG0501	Belongs to the peptidase M48B family
B7L66_RS08855	COG2081	HI0933 family
B7L66_RS08860	COG4681	YaeQ
B7L66_RS08870	COG0625	glutathione transferase activity
B7L66_RS08880	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B7L66_RS08885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B7L66_RS08890	COG0513	Belongs to the DEAD box helicase family
B7L66_RS08895	COG0488	(ABC) transporter
B7L66_RS08915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B7L66_RS08920	COG0483	inositol monophosphate 1-phosphatase activity
B7L66_RS08935	COG5001	Diguanylate cyclase
B7L66_RS08935	COG3300	MHYT domain
B7L66_RS08940	COG1509	lysine 2,3-aminomutase activity
B7L66_RS08945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B7L66_RS08955	COG0402	S-adenosylhomocysteine deaminase activity
B7L66_RS08960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B7L66_RS09025	COG4302	ethanolamine ammonia-lyase activity
B7L66_RS09055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B7L66_RS09060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B7L66_RS09075	COG2166	iron-sulfur cluster assembly
B7L66_RS09080	COG0215	cysteine-tRNA ligase activity
B7L66_RS09090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B7L66_RS09095	COG0137	argininosuccinate synthase activity
B7L66_RS09105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B7L66_RS09110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B7L66_RS09120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B7L66_RS09125	COG0165	Argininosuccinate lyase
B7L66_RS09135	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B7L66_RS09140	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B7L66_RS09170	COG1294	oxidase, subunit
B7L66_RS09180	COG4988	ABC transporter
B7L66_RS09185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B7L66_RS09190	COG1278	Cold shock
B7L66_RS09195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L66_RS09215	COG1138	Cytochrome C-type biogenesis protein
B7L66_RS09220	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B7L66_RS09240	COG4133	protoheme IX ABC transporter activity
B7L66_RS09245	COG0436	Aminotransferase
B7L66_RS09265	COG1187	pseudouridine synthase activity
B7L66_RS09270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B7L66_RS09275	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B7L66_RS09280	COG2350	Protein conserved in bacteria
B7L66_RS09310	COG1175	transmembrane transport
B7L66_RS09315	COG0395	ABC-type sugar transport system, permease component
B7L66_RS09340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B7L66_RS09345	COG2957	Belongs to the agmatine deiminase family
B7L66_RS09365	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B7L66_RS09370	COG0539	negative regulation of cytoplasmic translation
B7L66_RS09375	COG0776	regulation of translation
B7L66_RS09385	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B7L66_RS09390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7L66_RS09400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B7L66_RS09405	COG0475	glutathione-regulated potassium exporter activity
B7L66_RS09405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B7L66_RS09415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B7L66_RS09425	COG0519	Catalyzes the synthesis of GMP from XMP
B7L66_RS09425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B7L66_RS09430	COG0582	viral genome integration into host DNA
B7L66_RS09465	COG2003	Belongs to the UPF0758 family
B7L66_RS09485	COG2084	Dehydrogenase
B7L66_RS09565	COG0210	DNA helicase
B7L66_RS09715	COG2207	Transcriptional regulator
B7L66_RS09720	COG2807	transmembrane transport
B7L66_RS09735	COG3938	Belongs to the proline racemase family
B7L66_RS09745	COG2249	NAD(P)H dehydrogenase (quinone) activity
B7L66_RS09760	COG5006	permease, DMT superfamily
B7L66_RS09770	COG4804	nuclease activity
B7L66_RS09820	COG0270	DNA (cytosine-5-)-methyltransferase activity
B7L66_RS09875	COG2274	protein secretion by the type I secretion system
B7L66_RS09920	COG2273	Hydrolase Family 16
B7L66_RS09920	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
B7L66_RS09945	COG2336	PFAM SpoVT AbrB
B7L66_RS09970	COG4774	siderophore transport
B7L66_RS09980	COG0582	viral genome integration into host DNA
B7L66_RS10005	COG2003	Belongs to the UPF0758 family
B7L66_RS10010	COG5489	Protein of unknown function (DUF736)
B7L66_RS10015	COG1396	sequence-specific DNA binding
B7L66_RS10025	COG3002	Belongs to the UPF0753 family
B7L66_RS10030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B7L66_RS10035	COG0583	DNA-binding transcription factor activity
B7L66_RS10050	COG2197	response regulator
B7L66_RS10065	COG1335	isochorismatase
B7L66_RS10080	COG2814	Major facilitator Superfamily
B7L66_RS10095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B7L66_RS10095	COG1648	precorrin-2 dehydrogenase activity
B7L66_RS10120	COG3685	Protein conserved in bacteria
B7L66_RS10140	COG5001	Diguanylate cyclase
B7L66_RS10155	COG4566	intracellular signal transduction
B7L66_RS10205	COG3279	Response regulator of the LytR AlgR family
B7L66_RS10240	COG1238	metal cluster binding
B7L66_RS10380	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS10390	COG1073	alpha beta
B7L66_RS10390	COG2226	methyltransferase
B7L66_RS10435	COG0316	Belongs to the HesB IscA family
B7L66_RS10435	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B7L66_RS10440	COG2154	pterin-4-alpha-carbinolamine dehydratase
B7L66_RS10450	COG0428	transporter
B7L66_RS10455	COG3064	Membrane
B7L66_RS10465	COG1530	ribonuclease E activity
B7L66_RS10475	COG1054	Belongs to the UPF0176 family
B7L66_RS10495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B7L66_RS10505	COG0582	viral genome integration into host DNA
B7L66_RS10525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L66_RS10550	COG3039	Transposase
B7L66_RS10595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B7L66_RS10665	COG0629	single-stranded DNA binding
B7L66_RS10670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L66_RS10675	COG0270	DNA (cytosine-5-)-methyltransferase activity
B7L66_RS10855	COG2003	Belongs to the UPF0758 family
B7L66_RS10975	COG0583	DNA-binding transcription factor activity
B7L66_RS10990	COG1396	sequence-specific DNA binding
B7L66_RS11000	COG0582	viral genome integration into host DNA
B7L66_RS11020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B7L66_RS11025	COG0322	excinuclease ABC activity
B7L66_RS11035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B7L66_RS11040	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B7L66_RS11045	COG1663	tetraacyldisaccharide 4'-kinase activity
B7L66_RS11050	COG1132	(ABC) transporter
B7L66_RS11060	COG0811	peptide transport
B7L66_RS11075	COG1136	(ABC) transporter
B7L66_RS11080	COG4591	ABC-type transport system involved in lipoprotein release permease component
B7L66_RS11090	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B7L66_RS11095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B7L66_RS11110	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B7L66_RS11135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B7L66_RS11140	COG0837	glucose binding
B7L66_RS11145	COG0363	glucosamine-6-phosphate deaminase activity
B7L66_RS11150	COG0129	dihydroxy-acid dehydratase activity
B7L66_RS11155	COG0800	Aldolase
B7L66_RS11230	COG0784	Response regulator, receiver
B7L66_RS11230	COG2205	protein histidine kinase activity
B7L66_RS11235	COG2183	response to ionizing radiation
B7L66_RS11245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L66_RS11245	COG0723	plastoquinol--plastocyanin reductase activity
B7L66_RS11260	COG3243	poly(R)-hydroxyalkanoic acid synthase
B7L66_RS11270	COG1183	phosphatidylcholine synthase activity
B7L66_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS11290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B7L66_RS11300	COG0668	transmembrane transport
B7L66_RS11305	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B7L66_RS11320	COG1914	H( )-stimulated, divalent metal cation uptake system
B7L66_RS11335	COG0746	molybdenum cofactor guanylyltransferase activity
B7L66_RS11340	COG0303	'Molybdopterin
B7L66_RS11350	COG0708	Exodeoxyribonuclease III
B7L66_RS11390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B7L66_RS11395	COG0303	'Molybdopterin
B7L66_RS11400	COG1160	GTP binding
B7L66_RS11405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L66_RS11415	COG1426	Protein conserved in bacteria
B7L66_RS11425	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B7L66_RS11440	COG1024	Enoyl-CoA hydratase
B7L66_RS11440	COG1250	3-hydroxyacyl-CoA dehydrogenase
B7L66_RS11445	COG0183	Belongs to the thiolase family
B7L66_RS11455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B7L66_RS11460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B7L66_RS11470	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B7L66_RS11480	COG1674	ftsk spoiiie
B7L66_RS11485	COG0492	ferredoxin-NADP+ reductase activity
B7L66_RS11495	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B7L66_RS11505	COG0542	response to heat
B7L66_RS11520	COG0482	sulfurtransferase activity
B7L66_RS11525	COG2915	High frequency lysogenization protein hflD homolog
B7L66_RS11555	COG5002	protein histidine kinase activity
B7L66_RS11580	COG0784	Response regulator, receiver
B7L66_RS11580	COG0835	chemotaxis
B7L66_RS11590	COG1558	bacterial-type flagellum-dependent cell motility
B7L66_RS11595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B7L66_RS11605	COG4787	bacterial-type flagellum-dependent cell motility
B7L66_RS11615	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B7L66_RS11620	COG1706	bacterial-type flagellum-dependent cell motility
B7L66_RS11625	COG3951	Flagellar rod assembly protein muramidase FlgJ
B7L66_RS11625	COG1705	Flagellar rod assembly protein muramidase FlgJ
B7L66_RS11635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B7L66_RS11645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B7L66_RS11650	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B7L66_RS11680	COG2201	protein-glutamate methylesterase activity
B7L66_RS11700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L66_RS11705	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS11710	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS11740	COG1677	Flagellar hook-basal body complex protein FliE
B7L66_RS11790	COG3190	flagellar
B7L66_RS11805	COG1684	flagellar biosynthetic protein fliR
B7L66_RS11835	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B7L66_RS11865	COG2198	Histidine kinase
B7L66_RS11865	COG0784	Response regulator, receiver
B7L66_RS11865	COG0643	Histidine kinase
B7L66_RS11880	COG0641	radical SAM
B7L66_RS11925	COG5002	protein histidine kinase activity
B7L66_RS11930	COG0745	RESPONSE REGULATOR receiver
B7L66_RS12015	COG2003	Belongs to the UPF0758 family
B7L66_RS12040	COG0784	Response regulator, receiver
B7L66_RS12040	COG4191	Histidine kinase
B7L66_RS12045	COG4191	Histidine kinase
B7L66_RS12045	COG0784	Response regulator, receiver
B7L66_RS12100	COG2963	transposase activity
B7L66_RS12215	COG3002	Belongs to the UPF0753 family
B7L66_RS12305	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B7L66_RS12310	COG1360	Flagellar Motor Protein
B7L66_RS12320	COG0835	chemotaxis
B7L66_RS12330	COG0745	RESPONSE REGULATOR receiver
B7L66_RS12335	COG2198	Histidine kinase
B7L66_RS12335	COG0643	Histidine kinase
B7L66_RS12340	COG0840	transmembrane signaling receptor activity
B7L66_RS12355	COG0840	transmembrane signaling receptor activity
B7L66_RS12370	COG0840	transmembrane signaling receptor activity
B7L66_RS12375	COG0840	transmembrane signaling receptor activity
B7L66_RS12380	COG0840	transmembrane signaling receptor activity
B7L66_RS12385	COG0840	transmembrane signaling receptor activity
B7L66_RS12395	COG0840	transmembrane signaling receptor activity
B7L66_RS12400	COG0840	transmembrane signaling receptor activity
B7L66_RS12405	COG0840	transmembrane signaling receptor activity
B7L66_RS12410	COG0840	transmembrane signaling receptor activity
B7L66_RS12415	COG0840	transmembrane signaling receptor activity
B7L66_RS12425	COG0835	chemotaxis
B7L66_RS12435	COG0840	transmembrane signaling receptor activity
B7L66_RS12445	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B7L66_RS12450	COG2201	protein-glutamate methylesterase activity
B7L66_RS12460	COG2267	carboxylic ester hydrolase activity
B7L66_RS12490	COG0318	PFAM AMP-dependent synthetase and ligase
B7L66_RS12495	COG1024	Enoyl-CoA hydratase
B7L66_RS12500	COG0784	Response regulator, receiver
B7L66_RS12500	COG2198	Histidine kinase
B7L66_RS12500	COG2205	protein histidine kinase activity
B7L66_RS12510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B7L66_RS12515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B7L66_RS12520	COG3279	Response regulator of the LytR AlgR family
B7L66_RS12560	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B7L66_RS12570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L66_RS12575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B7L66_RS12585	COG0505	Belongs to the CarA family
B7L66_RS12590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B7L66_RS12595	COG2258	MOSC domain
B7L66_RS12600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L66_RS12645	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B7L66_RS12665	COG0277	FAD linked oxidase domain protein
B7L66_RS12670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B7L66_RS12680	COG0531	amino acid
B7L66_RS12685	COG0531	amino acid
B7L66_RS12690	COG0235	Class ii aldolase
B7L66_RS12695	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B7L66_RS12700	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
B7L66_RS12715	COG0140	phosphoribosyl-ATP diphosphatase activity
B7L66_RS12715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B7L66_RS12720	COG0107	imidazoleglycerol-phosphate synthase activity
B7L66_RS12725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B7L66_RS12730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B7L66_RS12735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B7L66_RS12735	COG0131	Imidazoleglycerol-phosphate dehydratase
B7L66_RS12740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L66_RS12745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B7L66_RS12750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B7L66_RS12760	COG0124	histidyl-tRNA synthetase
B7L66_RS12765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L66_RS12815	COG3210	domain, Protein
B7L66_RS12825	COG3210	domain, Protein
B7L66_RS12840	COG1649	PFAM Uncharacterised BCR, COG1649
B7L66_RS12840	COG0726	polysaccharide deacetylase
B7L66_RS12845	COG1215	transferase activity, transferring glycosyl groups
B7L66_RS12860	COG1012	belongs to the aldehyde dehydrogenase family
B7L66_RS12880	COG0167	dihydroorotate dehydrogenase activity
B7L66_RS12885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B7L66_RS12890	COG0697	spore germination
B7L66_RS12900	COG1794	racemase activity, acting on amino acids and derivatives
B7L66_RS12915	COG0671	phosphoesterase, PA-phosphatase related
B7L66_RS12920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B7L66_RS12935	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B7L66_RS12940	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L66_RS12950	COG2203	Gaf domain
B7L66_RS12950	COG3706	GGDEF domain
B7L66_RS12950	COG4251	negative regulation of phosphorylation
B7L66_RS12950	COG5001	Diguanylate cyclase
B7L66_RS12965	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L66_RS12990	COG0166	Belongs to the GPI family
B7L66_RS12995	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B7L66_RS13000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B7L66_RS13005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B7L66_RS13025	COG1469	GTP cyclohydrolase I activity
B7L66_RS13030	COG0860	N-Acetylmuramoyl-L-alanine amidase
B7L66_RS13050	COG0477	Major facilitator Superfamily
B7L66_RS13055	COG2115	Belongs to the xylose isomerase family
B7L66_RS13060	COG1070	Carbohydrate kinase
B7L66_RS13070	COG1501	Belongs to the glycosyl hydrolase 31 family
B7L66_RS13120	COG0800	Aldolase
B7L66_RS13125	COG4948	Mandelate Racemase Muconate Lactonizing
B7L66_RS13135	COG3734	2-keto-3-deoxy-galactonokinase
B7L66_RS13140	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B7L66_RS13150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L66_RS13165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B7L66_RS13170	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B7L66_RS13185	COG0352	thiamine-phosphate diphosphorylase activity
B7L66_RS13185	COG0351	phosphomethylpyrimidine kinase
B7L66_RS13210	COG0583	DNA-binding transcription factor activity
B7L66_RS13215	COG1741	Belongs to the pirin family
B7L66_RS13235	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B7L66_RS13240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B7L66_RS13245	COG2137	regulation of response to DNA damage stimulus
B7L66_RS13255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B7L66_RS13260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B7L66_RS13270	COG1546	Belongs to the CinA family
B7L66_RS13275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B7L66_RS13285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B7L66_RS13290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B7L66_RS13300	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B7L66_RS13305	COG1534	Rna-binding protein
B7L66_RS13320	COG1238	metal cluster binding
B7L66_RS13325	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B7L66_RS13330	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B7L66_RS13335	COG2840	Smr protein MutS2
B7L66_RS13340	COG0585	pseudouridine synthase activity
B7L66_RS13345	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B7L66_RS13350	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B7L66_RS13355	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B7L66_RS13360	COG0148	phosphopyruvate hydratase activity
B7L66_RS13370	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B7L66_RS13375	COG0504	CTP synthase activity
B7L66_RS13400	COG0306	phosphate transporter
B7L66_RS13415	COG1253	flavin adenine dinucleotide binding
B7L66_RS13430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L66_RS13435	COG0477	Major facilitator Superfamily
B7L66_RS13445	COG1136	(ABC) transporter
B7L66_RS13460	COG0438	transferase activity, transferring glycosyl groups
B7L66_RS13470	COG2264	protein methyltransferase activity
B7L66_RS13505	COG2244	polysaccharide biosynthetic process
B7L66_RS13560	COG1595	DNA-templated transcription, initiation
B7L66_RS13575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B7L66_RS13585	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B7L66_RS13595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7L66_RS13610	COG4191	Histidine kinase
B7L66_RS13610	COG0784	Response regulator, receiver
B7L66_RS13615	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
B7L66_RS13650	COG0840	transmembrane signaling receptor activity
B7L66_RS13665	COG0583	DNA-binding transcription factor activity
B7L66_RS13670	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B7L66_RS13675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B7L66_RS13690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B7L66_RS13695	COG0077	Prephenate dehydratase
B7L66_RS13695	COG1605	Chorismate mutase
B7L66_RS13700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B7L66_RS13705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B7L66_RS13710	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B7L66_RS13755	COG1228	amidohydrolase
B7L66_RS13760	COG2986	histidine ammonia-lyase
B7L66_RS13770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B7L66_RS13785	COG4993	Dehydrogenase
B7L66_RS13795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B7L66_RS13810	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B7L66_RS13815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B7L66_RS13820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L66_RS13830	COG3115	cell septum assembly
B7L66_RS13840	COG0359	binds to the 23S rRNA
B7L66_RS13845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B7L66_RS13850	COG0360	Binds together with S18 to 16S ribosomal RNA
B7L66_RS13855	COG0316	Belongs to the HesB IscA family
B7L66_RS13865	COG0017	Asparaginyl-tRNA synthetase
B7L66_RS13885	COG2808	Putative FMN-binding domain
B7L66_RS13950	COG0288	reversible hydration of carbon dioxide
B7L66_RS13955	COG0662	Cupin 2, conserved barrel domain protein
B7L66_RS13965	COG3844	kynureninase activity
B7L66_RS13970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L66_RS13980	COG2925	Exonuclease
B7L66_RS14005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B7L66_RS14020	COG0488	(ABC) transporter
B7L66_RS14055	COG0494	nUDIX hydrolase
B7L66_RS14065	COG1024	Enoyl-CoA hydratase
B7L66_RS14075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B7L66_RS14080	COG0659	secondary active sulfate transmembrane transporter activity
B7L66_RS14105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B7L66_RS14110	COG0573	inorganic phosphate transmembrane transporter activity
B7L66_RS14115	COG0581	inorganic phosphate transmembrane transporter activity
B7L66_RS14120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B7L66_RS14125	COG0704	Plays a role in the regulation of phosphate uptake
B7L66_RS14135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B7L66_RS14145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L66_RS14155	COG0557	exoribonuclease II activity
B7L66_RS14175	COG1960	acyl-CoA dehydrogenase activity
B7L66_RS14180	COG1960	acyl-CoA dehydrogenase activity
B7L66_RS14185	COG1960	acyl-CoA dehydrogenase activity
B7L66_RS14190	COG1960	acyl-CoA dehydrogenase activity
B7L66_RS14195	COG2226	methyltransferase
B7L66_RS14200	COG0646	methionine synthase
B7L66_RS14200	COG1410	methionine synthase
B7L66_RS14205	COG0646	methionine synthase
B7L66_RS14205	COG1410	methionine synthase
B7L66_RS14215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L66_RS14240	COG2900	Belongs to the SlyX family
B7L66_RS14255	COG0386	Belongs to the glutathione peroxidase family
B7L66_RS14265	COG1725	Transcriptional regulator
B7L66_RS14270	COG1131	(ABC) transporter
B7L66_RS14300	COG1253	flavin adenine dinucleotide binding
B7L66_RS14320	COG2850	peptidyl-arginine hydroxylation
B7L66_RS14355	COG1132	(ABC) transporter
B7L66_RS14360	COG0583	DNA-binding transcription factor activity
B7L66_RS14390	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B7L66_RS14405	COG0484	heat shock protein binding
B7L66_RS14410	COG0443	Heat shock 70 kDa protein
B7L66_RS14415	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B7L66_RS14420	COG1420	regulation of RNA biosynthetic process
B7L66_RS14425	COG0497	DNA recombination
B7L66_RS14435	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L66_RS14450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B7L66_RS14565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B7L66_RS14595	COG2022	thiamine diphosphate biosynthetic process
B7L66_RS14605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B7L66_RS14610	COG0471	metal ion transport
B7L66_RS14610	COG3273	potassium ion transport
B7L66_RS14635	COG1970	mechanosensitive ion channel activity
B7L66_RS14655	COG3250	beta-galactosidase activity
B7L66_RS14660	COG4948	Mandelate Racemase Muconate Lactonizing
B7L66_RS14675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L66_RS14685	COG0308	aminopeptidase N
B7L66_RS14730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L66_RS14740	COG2895	sulfate adenylyltransferase (ATP) activity
B7L66_RS14740	COG0529	Catalyzes the synthesis of activated sulfate
B7L66_RS14745	COG0175	sulfate reduction
B7L66_RS14750	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B7L66_RS14755	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7L66_RS14760	COG0175	sulfate reduction
B7L66_RS14780	COG2205	protein histidine kinase activity
B7L66_RS14780	COG2198	Histidine kinase
B7L66_RS14780	COG0784	Response regulator, receiver
B7L66_RS14800	COG1648	precorrin-2 dehydrogenase activity
B7L66_RS14800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B7L66_RS14815	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B7L66_RS14820	COG3588	fructose-bisphosphate aldolase
B7L66_RS14835	COG0469	pyruvate kinase activity
B7L66_RS14845	COG0126	phosphoglycerate kinase activity
B7L66_RS14870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B7L66_RS14880	COG3047	cAMP biosynthetic process
B7L66_RS14885	COG3047	cAMP biosynthetic process
B7L66_RS14895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L66_RS14895	COG3453	Protein conserved in bacteria
B7L66_RS14900	COG0725	ABC transporter, periplasmic molybdate-binding protein
B7L66_RS14905	COG4149	molybdate abc transporter
B7L66_RS14910	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B7L66_RS14945	COG1376	ErfK ybiS ycfS ynhG family protein
B7L66_RS14950	COG0739	heme binding
B7L66_RS14960	COG4773	Receptor
B7L66_RS14965	COG0596	Alpha beta hydrolase
B7L66_RS14970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B7L66_RS14990	COG2304	oxidoreductase activity
B7L66_RS15010	COG0714	Associated with various cellular activities
B7L66_RS15045	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B7L66_RS15070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B7L66_RS15080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B7L66_RS15090	COG0194	GDP metabolic process
B7L66_RS15095	COG1561	YicC-like family, N-terminal region
B7L66_RS15100	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B7L66_RS15110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B7L66_RS15115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B7L66_RS15130	COG0006	proline dipeptidase activity
B7L66_RS15140	COG0006	proline dipeptidase activity
B7L66_RS15145	COG3079	Belongs to the UPF0149 family
B7L66_RS15165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B7L66_RS15175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B7L66_RS15185	COG2912	Transglutaminase-like superfamily
B7L66_RS15190	COG1773	rubredoxin
B7L66_RS15195	COG0352	thiamine-phosphate diphosphorylase activity
B7L66_RS15210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B7L66_RS15225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L66_RS15255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B7L66_RS15260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L66_RS15270	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS15280	COG0671	phosphoesterase, PA-phosphatase related
B7L66_RS15285	COG3781	membrane
B7L66_RS15295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B7L66_RS15300	COG0563	adenylate kinase activity
B7L66_RS15315	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B7L66_RS15325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B7L66_RS15345	COG3710	Transcriptional regulator
B7L66_RS15350	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B7L66_RS15365	COG0840	transmembrane signaling receptor activity
B7L66_RS15370	COG0405	Gamma-glutamyltransferase
B7L66_RS15375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B7L66_RS15395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B7L66_RS15400	COG0473	3-isopropylmalate dehydrogenase activity
B7L66_RS15405	COG0066	3-isopropylmalate dehydratase activity
B7L66_RS15410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B7L66_RS15430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B7L66_RS15435	COG1538	Outer membrane efflux protein
B7L66_RS15440	COG1519	Transferase
B7L66_RS15450	COG1560	Kdo2-lipid A biosynthetic process
B7L66_RS15475	COG0281	malic enzyme
B7L66_RS15475	COG0280	phosphate acetyltransferase
B7L66_RS15480	COG1301	dicarboxylic acid transport
B7L66_RS15505	COG0583	DNA-binding transcription factor activity
B7L66_RS15515	COG0667	Aldo Keto reductase
B7L66_RS15530	COG2197	response regulator
B7L66_RS15540	COG0642	Histidine kinase
B7L66_RS15560	COG2851	Citrate transporter
B7L66_RS15565	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS15570	COG1609	Transcriptional regulator
B7L66_RS15575	COG2211	Major facilitator Superfamily
B7L66_RS15600	COG1162	GTPase activity
B7L66_RS15630	COG4773	Receptor
B7L66_RS15635	COG0726	polysaccharide deacetylase
B7L66_RS15640	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B7L66_RS15680	COG1307	EDD domain protein, DegV family
B7L66_RS15685	COG0242	peptide deformylase activity
B7L66_RS15715	COG0457	Tetratricopeptide repeat
B7L66_RS15720	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B7L66_RS15725	COG1215	transferase activity, transferring glycosyl groups
B7L66_RS15730	COG1215	transferase activity, transferring glycosyl groups
B7L66_RS15745	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B7L66_RS15800	COG2188	Transcriptional regulator
B7L66_RS15810	COG1450	Type ii and iii secretion system protein
B7L66_RS15825	COG3166	PFAM Fimbrial assembly family protein
B7L66_RS15830	COG3156	type II secretion system protein K
B7L66_RS15835	COG4795	General secretion pathway protein
B7L66_RS15840	COG2165	general secretion pathway protein
B7L66_RS15845	COG4970	Tfp pilus assembly protein FimT
B7L66_RS15850	COG2165	general secretion pathway protein
B7L66_RS15855	COG1459	type II secretion system
B7L66_RS15865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L66_RS15870	COG1404	Belongs to the peptidase S8 family
B7L66_RS15875	COG5295	Hep Hag repeat protein
B7L66_RS15880	COG1404	Belongs to the peptidase S8 family
B7L66_RS15885	COG5295	Hep Hag repeat protein
B7L66_RS15895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B7L66_RS15895	COG0047	phosphoribosylformylglycinamidine synthase activity
B7L66_RS15910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B7L66_RS15925	COG4974	Belongs to the 'phage' integrase family
B7L66_RS15940	COG0795	lipopolysaccharide-transporting ATPase activity
B7L66_RS15950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B7L66_RS15965	COG0525	valine-tRNA ligase activity
B7L66_RS15995	COG1183	phosphatidylcholine synthase activity
B7L66_RS16005	COG0442	prolyl-tRNA aminoacylation
B7L66_RS16020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B7L66_RS16025	COG1127	ABC transporter
B7L66_RS16030	COG3218	ABC-type transport auxiliary lipoprotein component
B7L66_RS16030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B7L66_RS16065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L66_RS16070	COG0662	Cupin 2, conserved barrel domain protein
B7L66_RS16070	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B7L66_RS16105	COG2086	electron transfer activity
B7L66_RS16120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B7L66_RS16120	COG0546	phosphoglycolate phosphatase activity
B7L66_RS16125	COG0277	FAD linked oxidase domain protein
B7L66_RS16130	COG0300	oxidoreductase activity
B7L66_RS16140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L66_RS16160	COG2226	methyltransferase
B7L66_RS16170	COG3754	Rhamnan synthesis protein F
B7L66_RS16175	COG0438	transferase activity, transferring glycosyl groups
B7L66_RS16175	COG1216	Glycosyl transferase, family 2
B7L66_RS16180	COG0110	maltose O-acetyltransferase activity
B7L66_RS16195	COG0626	cystathionine gamma-synthase activity
B7L66_RS16225	COG0625	glutathione transferase activity
B7L66_RS16240	COG0513	Belongs to the DEAD box helicase family
B7L66_RS16250	COG4206	TonB-dependent receptor
B7L66_RS16255	COG0720	synthase
B7L66_RS16265	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B7L66_RS16275	COG1956	GAF domain-containing protein
B7L66_RS16285	COG2819	hydrolase of the alpha beta superfamily
B7L66_RS16300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L66_RS16305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L66_RS16320	COG0339	signal peptide processing
B7L66_RS16375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B7L66_RS16380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L66_RS16385	COG4591	ABC-type transport system involved in lipoprotein release permease component
B7L66_RS16385	COG1136	(ABC) transporter
B7L66_RS16390	COG0577	efflux transmembrane transporter activity
B7L66_RS16410	COG4191	Histidine kinase
B7L66_RS16415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B7L66_RS16430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B7L66_RS16435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B7L66_RS16440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B7L66_RS16445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B7L66_RS16450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B7L66_RS16455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B7L66_RS16465	COG0356	it plays a direct role in the translocation of protons across the membrane
B7L66_RS16485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L66_RS16495	COG0508	dehydrogenase complex catalyzes the overall conversion of
B7L66_RS16535	COG2011	ABC-type metal ion transport system permease component
B7L66_RS16540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B7L66_RS16545	COG0697	spore germination
B7L66_RS16550	COG1666	GTP binding
B7L66_RS16560	COG0784	Response regulator, receiver
B7L66_RS16560	COG2198	Histidine kinase
B7L66_RS16560	COG5002	protein histidine kinase activity
B7L66_RS16580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B7L66_RS16585	COG1187	pseudouridine synthase activity
B7L66_RS16590	COG2813	Specifically methylates the guanine in position
B7L66_RS16610	COG2202	Pas domain
B7L66_RS16610	COG2205	protein histidine kinase activity
B7L66_RS16630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B7L66_RS16635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L66_RS16700	COG0842	Transport permease protein
B7L66_RS16705	COG1131	(ABC) transporter
B7L66_RS16710	COG0025	NhaP-type Na H and K H
B7L66_RS16720	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B7L66_RS16725	COG1573	uracil-dna glycosylase
B7L66_RS16735	COG3384	dioxygenase
B7L66_RS16745	COG0583	DNA-binding transcription factor activity
B7L66_RS16755	COG0667	Aldo Keto reductase
B7L66_RS16770	COG3590	peptidase
B7L66_RS16790	COG0531	amino acid
B7L66_RS16805	COG2972	Histidine kinase
B7L66_RS16830	COG3685	Protein conserved in bacteria
B7L66_RS16835	COG3546	catalase activity
B7L66_RS16885	COG1271	oxidase subunit
B7L66_RS16890	COG1294	oxidase, subunit
B7L66_RS16905	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS16910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B7L66_RS16930	COG1132	(ABC) transporter
B7L66_RS16945	COG1063	alcohol dehydrogenase
B7L66_RS17020	COG0251	oxidation-reduction process
B7L66_RS17035	COG0840	transmembrane signaling receptor activity
B7L66_RS17050	COG0583	DNA-binding transcription factor activity
B7L66_RS17055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B7L66_RS17095	COG0024	Methionine aminopeptidase
B7L66_RS17130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L66_RS17165	COG4695	Portal protein
B7L66_RS17175	COG4695	Portal protein
B7L66_RS17220	COG3179	chitinase
B7L66_RS17420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B7L66_RS17425	COG1490	D-aminoacyl-tRNA deacylase activity
B7L66_RS17430	COG1560	Kdo2-lipid A biosynthetic process
B7L66_RS17485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B7L66_RS17485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B7L66_RS17490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B7L66_RS17495	COG0242	peptide deformylase activity
B7L66_RS17500	COG1652	LysM domain
B7L66_RS17505	COG0758	DNA mediated transformation
B7L66_RS17525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L66_RS17525	COG1754	DNA topoisomerase type I activity
B7L66_RS17530	COG0009	L-threonylcarbamoyladenylate synthase
B7L66_RS17545	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS17555	COG0616	signal peptide processing
B7L66_RS17560	COG0534	Mate efflux family protein
B7L66_RS17580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B7L66_RS17585	COG0625	glutathione transferase activity
B7L66_RS17600	COG1252	NADH dehydrogenase
B7L66_RS17605	COG2860	membrane
B7L66_RS17610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B7L66_RS17615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B7L66_RS17620	COG3437	response regulator, receiver
B7L66_RS17625	COG2177	Part of the ABC transporter FtsEX involved in
B7L66_RS17630	COG2884	Cell division ATP-binding protein ftsE
B7L66_RS17635	COG0513	Belongs to the DEAD box helicase family
B7L66_RS17640	COG3118	belongs to the thioredoxin family
B7L66_RS17650	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B7L66_RS17660	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
B7L66_RS17665	COG0583	DNA-binding transcription factor activity
B7L66_RS17710	COG1518	maintenance of DNA repeat elements
B7L66_RS17725	COG1652	LysM domain
B7L66_RS17730	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B7L66_RS17730	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B7L66_RS17735	COG1473	amidohydrolase
B7L66_RS17740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L66_RS17745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L66_RS17755	COG5383	Protein conserved in bacteria
B7L66_RS17805	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B7L66_RS17810	COG3023	N-Acetylmuramoyl-L-alanine amidase
B7L66_RS17820	COG4948	Mandelate Racemase Muconate Lactonizing
B7L66_RS17830	COG0531	amino acid
B7L66_RS17845	COG4682	membrane
B7L66_RS17850	COG2133	pyrroloquinoline quinone binding
B7L66_RS17860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B7L66_RS17865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B7L66_RS17875	COG1610	YqeY-like protein
B7L66_RS17885	COG1295	ribonuclease BN
B7L66_RS17890	COG0358	DNA primase activity
B7L66_RS17905	COG0109	protoheme IX farnesyltransferase activity
B7L66_RS17935	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B7L66_RS17950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B7L66_RS17995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B7L66_RS18000	COG0739	heme binding
B7L66_RS18005	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B7L66_RS18015	COG2211	Major facilitator Superfamily
B7L66_RS18020	COG0708	Exodeoxyribonuclease III
B7L66_RS18025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B7L66_RS18035	COG1192	Involved in chromosome partitioning
B7L66_RS18040	COG1475	DNA binding
B7L66_RS18060	COG0463	Glycosyl transferase, family 2
B7L66_RS18080	COG0756	dUTP diphosphatase activity
B7L66_RS18085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B7L66_RS18090	COG2003	Belongs to the UPF0758 family
B7L66_RS18095	COG0018	arginyl-trna synthetase
B7L66_RS18110	COG4221	oxidoreductase activity
B7L66_RS18115	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B7L66_RS18115	COG2755	lipolytic protein G-D-S-L family
B7L66_RS18125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L66_RS18140	COG0606	chelatase, subunit chli
B7L66_RS18180	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B7L66_RS18185	COG1166	arginine decarboxylase activity
B7L66_RS18205	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B7L66_RS18245	COG1690	Belongs to the RtcB family
B7L66_RS18280	COG1090	epimerase
B7L66_RS18290	COG0642	Histidine kinase
B7L66_RS18320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7L66_RS18345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B7L66_RS18350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B7L66_RS18365	COG0753	catalase activity
B7L66_RS18385	COG2197	response regulator
B7L66_RS18390	COG4585	Histidine kinase
B7L66_RS18395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L66_RS18400	COG1136	(ABC) transporter
B7L66_RS18425	COG0697	spore germination
B7L66_RS18445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L66_RS18450	COG0180	Tryptophanyl-tRNA synthetase
B7L66_RS18455	COG3237	CsbD-like
B7L66_RS18500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B7L66_RS18515	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B7L66_RS18565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B7L66_RS18595	COG1199	ATP-dependent helicase activity
B7L66_RS18610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B7L66_RS18675	COG0625	glutathione transferase activity
B7L66_RS18715	COG4555	ABC transporter
B7L66_RS18725	COG1476	TRANSCRIPTIONal
B7L66_RS18770	COG0543	2 iron, 2 sulfur cluster binding
B7L66_RS18770	COG0633	Ferredoxin
B7L66_RS18775	COG1131	(ABC) transporter
B7L66_RS18780	COG0842	Transport permease protein
B7L66_RS18790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B7L66_RS18825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L66_RS18835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L66_RS18855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B7L66_RS18855	COG1042	CoA-binding domain protein
B7L66_RS18855	COG0045	succinate-CoA ligase (ADP-forming) activity
B7L66_RS18860	COG2239	Acts as a magnesium transporter
B7L66_RS18880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B7L66_RS18885	COG3387	PFAM Glycoside hydrolase 15-related
B7L66_RS18900	COG3100	YcgL domain-containing protein
B7L66_RS18905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B7L66_RS18915	COG0463	Glycosyl transferase, family 2
B7L66_RS18935	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS18970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L66_RS18985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B7L66_RS19035	COG0408	coproporphyrinogen oxidase activity
B7L66_RS19075	COG2815	serine threonine protein kinase
B7L66_RS19075	COG0515	serine threonine protein kinase
B7L66_RS19080	COG0631	protein serine/threonine phosphatase activity
B7L66_RS19260	COG0210	DNA helicase
B7L66_RS19275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L66_RS19280	COG0583	DNA-binding transcription factor activity
B7L66_RS19285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B7L66_RS19300	COG2159	amidohydrolase
B7L66_RS19320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L66_RS19340	COG0357	Ribosomal RNA small subunit methyltransferase G
B7L66_RS19345	COG3540	Alkaline phosphatase
B7L66_RS19355	COG2091	lysine biosynthetic process via aminoadipic acid
B7L66_RS19370	COG0708	Exodeoxyribonuclease III
B7L66_RS19375	COG1940	carbohydrate kinase activity
B7L66_RS19375	COG1846	Transcriptional regulator
B7L66_RS19385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L66_RS19395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B7L66_RS19400	COG3162	membrane
B7L66_RS19410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B7L66_RS19440	COG3507	Belongs to the glycosyl hydrolase 43 family
B7L66_RS19460	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS19465	COG0179	Fumarylacetoacetate (FAA) hydrolase
B7L66_RS19475	COG4948	Mandelate Racemase Muconate Lactonizing
B7L66_RS19485	COG3254	rhamnose metabolic process
B7L66_RS19490	COG0738	Major facilitator superfamily
B7L66_RS19495	COG1414	Transcriptional regulator
B7L66_RS19500	COG1971	Probably functions as a manganese efflux pump
B7L66_RS19505	COG2205	protein histidine kinase activity
B7L66_RS19520	COG3459	Glycosyltransferase 36 associated
B7L66_RS19525	COG2211	Major facilitator Superfamily
B7L66_RS19530	COG3265	gluconokinase activity
B7L66_RS19540	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L66_RS19560	COG2911	Protein conserved in bacteria
B7L66_RS19565	COG0729	surface antigen
B7L66_RS19595	COG0752	glycyl-tRNA synthetase alpha subunit
B7L66_RS19600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L66_RS19615	COG0519	Catalyzes the synthesis of GMP from XMP
B7L66_RS19615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B7L66_RS19625	COG0805	protein transport
B7L66_RS19630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B7L66_RS19635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B7L66_RS19645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B7L66_RS19670	COG2974	May be involved in recombination
B7L66_RS19685	COG2115	Belongs to the xylose isomerase family
B7L66_RS19695	COG3661	Belongs to the glycosyl hydrolase 67 family
B7L66_RS19705	COG4948	Mandelate Racemase Muconate Lactonizing
B7L66_RS19715	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L66_RS19720	COG0246	Mannitol dehydrogenase
B7L66_RS19770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B7L66_RS19800	COG3386	PFAM SMP-30 Gluconolaconase
B7L66_RS19810	COG3250	beta-galactosidase activity
B7L66_RS19815	COG1904	glucuronate isomerase
B7L66_RS19830	COG3693	PFAM glycoside hydrolase, family 10
B7L66_RS19845	COG2211	Major facilitator Superfamily
B7L66_RS19915	COG2937	Belongs to the GPAT DAPAT family
B7L66_RS19950	COG0284	orotidine-5'-phosphate decarboxylase activity
B7L66_RS19955	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B7L66_RS19965	COG3132	Protein of unknown function, DUF480
B7L66_RS19980	COG0210	DNA helicase
B7L66_RS19985	COG1435	thymidine kinase activity
B7L66_RS20000	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B7L66_RS20010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B7L66_RS20045	COG3135	benzoate transporter
B7L66_RS20065	COG0676	glucose-6-phosphate 1-epimerase activity
B7L66_RS20075	COG3012	SEC-C Motif Domain Protein
B7L66_RS20080	COG0730	response to heat
B7L66_RS20100	COG0302	gtp cyclohydrolase
B7L66_RS20115	COG1566	PFAM secretion protein HlyD family protein
B7L66_RS20125	COG1289	transmembrane transporter activity
B7L66_RS20130	COG0477	Major facilitator Superfamily
B7L66_RS20140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L66_RS20160	COG4691	Plasmid stability protein
B7L66_RS20165	COG1487	ribonuclease activity
B7L66_RS20190	COG0564	pseudouridine synthase activity
B7L66_RS20235	COG0439	Biotin carboxylase
B7L66_RS20290	COG1074	ATP-dependent DNA helicase activity
B7L66_RS20295	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B7L66_RS20310	COG1127	ABC transporter
B7L66_RS20315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B7L66_RS20320	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B7L66_RS20335	COG2853	Lipoprotein
B7L66_RS20345	COG0386	Belongs to the glutathione peroxidase family
B7L66_RS20355	COG1322	Protein conserved in bacteria
B7L66_RS20360	COG0604	alcohol dehydrogenase
B7L66_RS20380	COG0625	glutathione transferase activity
B7L66_RS20390	COG0531	amino acid
B7L66_RS20395	COG3537	Alpha-1,2-mannosidase
B7L66_RS20410	COG3706	GGDEF domain
B7L66_RS20415	COG3835	regulator
B7L66_RS20420	COG1929	Belongs to the glycerate kinase type-1 family
B7L66_RS20425	COG2271	Major facilitator Superfamily
B7L66_RS20440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B7L66_RS20450	COG0861	Integral membrane protein TerC family
B7L66_RS20465	COG0584	glycerophosphoryl diester phosphodiesterase
B7L66_RS20480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B7L66_RS20485	COG0726	polysaccharide deacetylase
B7L66_RS20490	COG0706	membrane insertase activity
B7L66_RS20495	COG0594	ribonuclease P activity
B7L66_RS20510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B7L66_RS20525	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B7L66_RS20530	COG0187	DNA topoisomerase II activity
B7L66_RS20540	COG0501	Belongs to the peptidase M48B family
B7L66_RS20570	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B7L66_RS20580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L66_RS20625	COG0793	Belongs to the peptidase S41A family
B7L66_RS20630	COG4942	peptidase
B7L66_RS20640	COG2234	aminopeptidase activity
B7L66_RS20650	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L66_RS20660	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L66_RS20670	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L66_RS20680	COG1064	alcohol dehydrogenase
B7L66_RS20685	COG0493	'glutamate synthase
B7L66_RS20690	COG0067	glutamate synthase
B7L66_RS20690	COG0069	glutamate synthase activity
B7L66_RS20690	COG0070	glutamate synthase
B7L66_RS20755	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B7L66_RS20760	COG0438	transferase activity, transferring glycosyl groups
B7L66_RS20760	COG0297	glycogen (starch) synthase activity
B7L66_RS20780	COG0367	asparagine synthase
B7L66_RS20810	COG1132	(ABC) transporter
B7L66_RS20840	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B7L66_RS20935	COG1111	helicase
B7L66_RS20935	COG1205	dead DEAH box helicase
B7L66_RS20940	COG1272	protein, Hemolysin III
B7L66_RS20960	COG0300	oxidoreductase activity
B7L66_RS20965	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS20990	COG2249	NAD(P)H dehydrogenase (quinone) activity
B7L66_RS21065	COG3237	CsbD-like
B7L66_RS21115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7L66_RS21125	COG0477	Major facilitator Superfamily
B7L66_RS21165	COG0714	Associated with various cellular activities
B7L66_RS21195	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B7L66_RS21205	COG4772	TonB-dependent receptor
B7L66_RS21215	COG0662	Cupin 2, conserved barrel domain protein
B7L66_RS21220	COG1012	belongs to the aldehyde dehydrogenase family
B7L66_RS21245	COG1304	FMN binding
B7L66_RS21260	COG4585	Histidine kinase
B7L66_RS21265	COG2197	response regulator
B7L66_RS21285	COG3710	Transcriptional regulator
B7L66_RS21290	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B7L66_RS21390	COG0366	Alpha amylase catalytic
B7L66_RS21395	COG0366	Alpha amylase catalytic
B7L66_RS21400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B7L66_RS21420	COG2755	lipolytic protein G-D-S-L family
B7L66_RS21420	COG0657	acetylesterase activity
B7L66_RS21440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B7L66_RS21460	COG1609	Transcriptional regulator
B7L66_RS21470	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B7L66_RS21475	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS21485	COG2755	lipolytic protein G-D-S-L family
B7L66_RS21500	COG3186	Phenylalanine-4-hydroxylase
B7L66_RS21505	COG1522	sequence-specific DNA binding
B7L66_RS21515	COG1752	Esterase of the alpha-beta hydrolase superfamily
B7L66_RS21525	COG1119	ATPase activity
B7L66_RS21540	COG1125	glycine betaine transport
B7L66_RS21575	COG1396	sequence-specific DNA binding
B7L66_RS21600	COG0489	protein tyrosine kinase activity
B7L66_RS21605	COG2062	phosphohistidine phosphatase, SixA
B7L66_RS21615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L66_RS21660	COG1968	undecaprenyl-diphosphatase activity
B7L66_RS21665	COG0174	glutamine synthetase
B7L66_RS21670	COG0347	Belongs to the P(II) protein family
B7L66_RS21675	COG0004	ammonium transporteR
B7L66_RS21680	COG3852	Histidine kinase
B7L66_RS21685	COG2204	response regulator
B7L66_RS21700	COG2032	superoxide dismutase activity
B7L66_RS21705	COG2032	superoxide dismutase activity
B7L66_RS21720	COG0183	Belongs to the thiolase family
B7L66_RS21755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B7L66_RS21760	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B7L66_RS21765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B7L66_RS21780	COG0028	Belongs to the TPP enzyme family
B7L66_RS21785	COG2205	protein histidine kinase activity
B7L66_RS21810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B7L66_RS21825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L66_RS21835	COG0596	Alpha beta hydrolase
B7L66_RS21840	COG0727	PFAM Uncharacterised protein family (UPF0153)
B7L66_RS21845	COG0318	PFAM AMP-dependent synthetase and ligase
B7L66_RS21850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L66_RS21865	COG1181	Belongs to the D-alanine--D-alanine ligase family
B7L66_RS21880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B7L66_RS21890	COG0564	pseudouridine synthase activity
B7L66_RS21915	COG0339	signal peptide processing
B7L66_RS21945	COG0475	glutathione-regulated potassium exporter activity
B7L66_RS21950	COG0583	DNA-binding transcription factor activity
B7L66_RS21955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B7L66_RS21960	COG2224	Isocitrate lyase
B7L66_RS21990	COG4770	biotin carboxylase activity
B7L66_RS21995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B7L66_RS22000	COG1960	acyl-CoA dehydrogenase activity
B7L66_RS22060	COG0523	cobalamin synthesis protein
B7L66_RS22070	COG0697	spore germination
B7L66_RS22080	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B7L66_RS22085	COG1846	Transcriptional regulator
B7L66_RS22090	COG1764	response to oxidative stress
B7L66_RS22120	COG2130	NADP-dependent
B7L66_RS22135	COG1187	pseudouridine synthase activity
B7L66_RS22160	COG1643	Atp-dependent helicase
B7L66_RS22170	COG4807	Protein conserved in bacteria
B7L66_RS22175	COG2351	hydroxyisourate hydrolase activity
B7L66_RS22180	COG2072	flavoprotein involved in K transport
B7L66_RS22200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B7L66_RS22235	COG1957	nucleoside hydrolase
B7L66_RS22245	COG2252	PERMEase
B7L66_RS22270	COG0084	hydrolase, TatD family'
B7L66_RS22285	COG0583	DNA-binding transcription factor activity
B7L66_RS22290	COG2814	Major facilitator Superfamily
B7L66_RS22315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B7L66_RS22320	COG1902	pentaerythritol trinitrate reductase activity
B7L66_RS22340	COG0745	RESPONSE REGULATOR receiver
B7L66_RS22345	COG2205	protein histidine kinase activity
B7L66_RS22350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L66_RS22370	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B7L66_RS22375	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L66_RS22380	COG0583	DNA-binding transcription factor activity
B7L66_RS22415	COG0702	epimerase
B7L66_RS22420	COG1733	regulation of RNA biosynthetic process
B7L66_RS22455	COG0129	dihydroxy-acid dehydratase activity
B7L66_RS22470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B7L66_RS22525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B7L66_RS22530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B7L66_RS22555	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B7L66_RS22560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B7L66_RS22570	COG3485	protocatechuate 3,4-dioxygenase
B7L66_RS22575	COG3485	protocatechuate 3,4-dioxygenase
B7L66_RS22585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L66_RS22590	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B7L66_RS22600	COG1414	Transcriptional regulator
B7L66_RS22610	COG0657	acetylesterase activity
B7L66_RS22620	COG0445	tRNA wobble uridine modification
B7L66_RS22630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B7L66_RS22660	COG2267	carboxylic ester hydrolase activity
B7L66_RS22670	COG0156	8-amino-7-oxononanoate synthase activity
B7L66_RS22675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B7L66_RS22680	COG1040	competence protein
B7L66_RS22685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B7L66_RS22775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B7L66_RS22845	COG1511	domain protein
B7L66_RS22845	COG3264	Mechanosensitive ion channel
B7L66_RS22850	COG1368	sulfuric ester hydrolase activity
B7L66_RS22860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B7L66_RS22865	COG2354	Protein conserved in bacteria
B7L66_RS22875	COG0297	glycogen (starch) synthase activity
B7L66_RS22880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B7L66_RS22885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B7L66_RS22910	COG0702	epimerase
B7L66_RS22915	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS22950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L66_RS22955	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_RS22965	COG0513	Belongs to the DEAD box helicase family
B7L66_RS22985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B7L66_RS22995	COG3483	tryptophan 2,3-dioxygenase activity
B7L66_RS23000	COG3104	oligopeptide transport
B7L66_RS23025	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B7L66_RS23045	COG1320	monovalent cation:proton antiporter activity
B7L66_RS23050	COG2212	antiporter activity
B7L66_RS23060	COG0651	ATP synthesis coupled electron transport
B7L66_RS23065	COG1006	Multisubunit Na H antiporter MnhC subunit
B7L66_RS23070	COG2111	Na H antiporter
B7L66_RS23070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B7L66_RS23095	COG3179	chitinase
B7L66_RS23125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B7L66_RS23130	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B7L66_RS23145	COG0456	acetyltransferase
B7L66_RS23150	COG1597	lipid kinase activity
B7L66_RS23175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B7L66_RS23180	COG0134	indole-3-glycerol-phosphate synthase activity
B7L66_RS23190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L66_RS23195	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B7L66_RS23205	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B7L66_RS23215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B7L66_RS23230	COG1051	belongs to the nudix hydrolase family
B7L66_RS23270	COG0316	Belongs to the HesB IscA family
B7L66_RS23290	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B7L66_RS23310	COG2814	Major facilitator Superfamily
B7L66_RS23315	COG0583	DNA-binding transcription factor activity
B7L66_RS23320	COG2814	Major facilitator Superfamily
B7L66_RS23325	COG1289	transmembrane transporter activity
B7L66_RS23335	COG0151	Belongs to the GarS family
B7L66_RS23345	COG0138	bifunctional purine biosynthesis protein purh
B7L66_RS23350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B7L66_RS23355	COG2267	carboxylic ester hydrolase activity
B7L66_RS23360	COG2453	phosphatase
B7L66_RS23360	COG0671	phosphoesterase, PA-phosphatase related
B7L66_RS23385	COG4589	Belongs to the CDS family
B7L66_RS23390	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B7L66_RS23410	COG2264	protein methyltransferase activity
B7L66_RS23440	COG0439	Biotin carboxylase
B7L66_RS23450	COG0511	ligase activity, forming carbon-carbon bonds
B7L66_RS23455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B7L66_RS23465	COG1324	tolerance protein
B7L66_RS23495	COG0300	oxidoreductase activity
B7L66_RS23500	COG2356	endonuclease I
B7L66_RS23515	COG0459	protein refolding
B7L66_RS23530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B7L66_RS23545	COG3386	PFAM SMP-30 Gluconolaconase
B7L66_RS23555	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B7L66_RS23560	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B7L66_RS23580	COG0778	Nitroreductase
B7L66_RS23585	COG2353	YceI-like domain
B7L66_RS23615	COG3052	prosthetic group binding
B7L66_RS23640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B7L66_RS23650	COG1802	Transcriptional regulator
B7L66_RS23705	COG4221	oxidoreductase activity
B7L66_RS23720	COG4221	oxidoreductase activity
B7L66_RS23730	COG0435	Glutathione S-transferase
B7L66_RS23755	COG2409	Drug exporters of the RND superfamily
B7L66_RS23765	COG1506	peptidase
B7L66_RS23765	COG0823	Involved in the tonB-independent uptake of proteins
B7L66_RS23810	COG0697	spore germination
B7L66_RS23825	COG1113	amino acid transport
B7L66_RS23845	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
B7L66_RS23895	COG5001	Diguanylate cyclase
B7L66_RS23900	COG0840	transmembrane signaling receptor activity
B7L66_RS23905	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L66_RS23905	COG5297	Belongs to the glycosyl hydrolase family 6
B7L66_RS23910	COG0659	secondary active sulfate transmembrane transporter activity
B7L66_RS23940	COG2943	transferase activity, transferring hexosyl groups
B7L66_RS23950	COG3275	phosphorelay sensor kinase activity
B7L66_RS23960	COG0181	hydroxymethylbilane synthase activity
B7L66_RS23990	COG1505	serine-type exopeptidase activity
B7L66_RS23995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B7L66_RS24000	COG0436	Aminotransferase
B7L66_RS24015	COG2832	Protein of unknown function (DUF454)
B7L66_RS24025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B7L66_RS24035	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B7L66_RS24040	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B7L66_RS24045	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B7L66_RS24070	COG2226	methyltransferase
B7L66_RS24075	COG5001	Diguanylate cyclase
B7L66_RS24075	COG3300	MHYT domain
B7L66_RS24080	COG0308	aminopeptidase N
B7L66_RS24130	COG3284	Transcriptional regulator
B7L66_RS24135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L66_RS24140	COG1077	Cell shape determining protein MreB Mrl
B7L66_RS24145	COG1792	Involved in formation and maintenance of cell shape
B7L66_RS24160	COG0772	Belongs to the SEDS family
B7L66_RS24170	COG2951	lytic endotransglycosylase activity
B7L66_RS24175	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B7L66_RS24185	COG1686	Belongs to the peptidase S11 family
B7L66_RS24195	COG2921	Belongs to the UPF0250 family
B7L66_RS24200	COG0321	lipoyl(octanoyl) transferase activity
B7L66_RS24585	COG1674	ftsk spoiiie
B7L66_RS24640	COG2801	Transposase and inactivated derivatives
B7L66_RS24690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L66_RS24700	COG0551	DNA topoisomerase type I activity
B7L66_RS24700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L66_RS24715	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B7L66_RS24780	COG0305	Participates in initiation and elongation during chromosome replication
B7L66_RS24885	COG4974	Belongs to the 'phage' integrase family
B7L66_RS24970	COG4644	lycopene metabolic process
B7L66_RS24975	COG2951	lytic endotransglycosylase activity
B7L66_RS25025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B7L66_RS25110	COG0653	protein targeting
B7L66_RS25135	COG2205	protein histidine kinase activity
B7L66_RS25135	COG0784	Response regulator, receiver
B7L66_RS25140	COG0745	RESPONSE REGULATOR receiver
B7L66_RS25260	COG0489	protein tyrosine kinase activity
B7L66_RS25360	COG4456	Virulence-associated protein
B7L66_RS25370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B7L66_RS25405	COG3318	Belongs to the UPF0149 family
B7L66_RS25405	COG3012	SEC-C Motif Domain Protein
B7L66_RS25425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs