locus-tag	class	description
K4A87_RS00035	COG0187	DNA topoisomerase II activity
K4A87_RS00045	COG0501	Belongs to the peptidase M48B family
K4A87_RS00095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K4A87_RS00105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4A87_RS00140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K4A87_RS00145	COG0793	Belongs to the peptidase S41A family
K4A87_RS00150	COG4942	peptidase
K4A87_RS00160	COG2234	aminopeptidase activity
K4A87_RS00195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K4A87_RS00205	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K4A87_RS00205	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K4A87_RS00215	COG1652	LysM domain
K4A87_RS00250	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K4A87_RS00255	COG3118	belongs to the thioredoxin family
K4A87_RS00265	COG2884	Cell division ATP-binding protein ftsE
K4A87_RS00270	COG2177	Part of the ABC transporter FtsEX involved in
K4A87_RS00275	COG2201	protein-glutamate methylesterase activity
K4A87_RS00280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K4A87_RS00285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K4A87_RS00295	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K4A87_RS00315	COG0534	Mate efflux family protein
K4A87_RS00320	COG0616	signal peptide processing
K4A87_RS00330	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_RS00340	COG0277	FAD linked oxidase domain protein
K4A87_RS00405	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K4A87_RS00410	COG5383	Protein conserved in bacteria
K4A87_RS00440	COG1609	Transcriptional regulator
K4A87_RS00450	COG0037	tRNA processing
K4A87_RS00455	COG2974	May be involved in recombination
K4A87_RS00475	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K4A87_RS00490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K4A87_RS00495	COG0805	protein transport
K4A87_RS00515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K4A87_RS00545	COG0067	glutamate synthase
K4A87_RS00545	COG0069	glutamate synthase activity
K4A87_RS00545	COG0070	glutamate synthase
K4A87_RS00550	COG0493	'glutamate synthase
K4A87_RS00555	COG1064	alcohol dehydrogenase
K4A87_RS00560	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K4A87_RS00570	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K4A87_RS00625	COG0366	Alpha amylase catalytic
K4A87_RS00630	COG0366	Alpha amylase catalytic
K4A87_RS00635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K4A87_RS00650	COG2755	lipolytic protein G-D-S-L family
K4A87_RS00650	COG0657	acetylesterase activity
K4A87_RS00660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K4A87_RS00680	COG1609	Transcriptional regulator
K4A87_RS00690	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K4A87_RS00695	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_RS00700	COG3186	Phenylalanine-4-hydroxylase
K4A87_RS00705	COG1522	sequence-specific DNA binding
K4A87_RS00710	COG1119	ATPase activity
K4A87_RS00730	COG1125	glycine betaine transport
K4A87_RS00745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K4A87_RS00775	COG0489	protein tyrosine kinase activity
K4A87_RS00780	COG2062	phosphohistidine phosphatase, SixA
K4A87_RS00790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4A87_RS00835	COG0174	glutamine synthetase
K4A87_RS00840	COG0347	Belongs to the P(II) protein family
K4A87_RS00845	COG0004	ammonium transporteR
K4A87_RS00850	COG3852	Histidine kinase
K4A87_RS00855	COG2204	response regulator
K4A87_RS00860	COG2032	superoxide dismutase activity
K4A87_RS00865	COG2032	superoxide dismutase activity
K4A87_RS00880	COG0183	Belongs to the thiolase family
K4A87_RS00915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K4A87_RS00925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K4A87_RS00935	COG0028	Belongs to the TPP enzyme family
K4A87_RS00945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K4A87_RS00955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K4A87_RS00960	COG3177	Filamentation induced by cAMP protein fic
K4A87_RS00965	COG0596	Alpha beta hydrolase
K4A87_RS00975	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_RS00980	COG0727	PFAM Uncharacterised protein family (UPF0153)
K4A87_RS00985	COG0318	PFAM AMP-dependent synthetase and ligase
K4A87_RS00990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K4A87_RS01055	COG0339	signal peptide processing
K4A87_RS01110	COG4770	biotin carboxylase activity
K4A87_RS01115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K4A87_RS01120	COG1960	acyl-CoA dehydrogenase activity
K4A87_RS01185	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K4A87_RS01195	COG1764	response to oxidative stress
K4A87_RS01215	COG0656	L-ascorbic acid biosynthetic process
K4A87_RS01220	COG2130	NADP-dependent
K4A87_RS01235	COG1187	pseudouridine synthase activity
K4A87_RS01275	COG1643	Atp-dependent helicase
K4A87_RS01290	COG4807	Protein conserved in bacteria
K4A87_RS01300	COG0084	hydrolase, TatD family'
K4A87_RS01305	COG2814	Major facilitator Superfamily
K4A87_RS01315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K4A87_RS01320	COG1902	pentaerythritol trinitrate reductase activity
K4A87_RS01340	COG2223	nitrite transmembrane transporter activity
K4A87_RS01360	COG2205	protein histidine kinase activity
K4A87_RS01390	COG1733	regulation of RNA biosynthetic process
K4A87_RS01455	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K4A87_RS01500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K4A87_RS01545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K4A87_RS01585	COG0156	8-amino-7-oxononanoate synthase activity
K4A87_RS01590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K4A87_RS01595	COG1040	competence protein
K4A87_RS01625	COG1404	Belongs to the peptidase S8 family
K4A87_RS01645	COG1511	domain protein
K4A87_RS01645	COG3264	Mechanosensitive ion channel
K4A87_RS01650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K4A87_RS01655	COG2354	Protein conserved in bacteria
K4A87_RS01660	COG1649	PFAM Uncharacterised BCR, COG1649
K4A87_RS01670	COG0297	glycogen (starch) synthase activity
K4A87_RS01675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K4A87_RS01680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K4A87_RS01710	COG0702	epimerase
K4A87_RS01720	COG1858	cytochrome C peroxidase
K4A87_RS01805	COG4232	protein-disulfide reductase activity
K4A87_RS01810	COG1324	tolerance protein
K4A87_RS01830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K4A87_RS01840	COG1196	nuclear chromosome segregation
K4A87_RS01880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K4A87_RS01900	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K4A87_RS01905	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K4A87_RS01920	COG2353	YceI-like domain
K4A87_RS02010	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_RS02020	COG1131	(ABC) transporter
K4A87_RS02085	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_RS02125	COG1132	(ABC) transporter
K4A87_RS02145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K4A87_RS02150	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_RS02170	COG2204	response regulator
K4A87_RS02205	COG3546	catalase activity
K4A87_RS02210	COG3685	Protein conserved in bacteria
K4A87_RS02225	COG0531	amino acid
K4A87_RS02240	COG3590	peptidase
K4A87_RS02260	COG1573	uracil-dna glycosylase
K4A87_RS02270	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K4A87_RS02285	COG0025	NhaP-type Na H and K H
K4A87_RS02340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K4A87_RS02345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K4A87_RS02360	COG2202	Pas domain
K4A87_RS02360	COG2205	protein histidine kinase activity
K4A87_RS02385	COG1187	pseudouridine synthase activity
K4A87_RS02420	COG1666	GTP binding
K4A87_RS02445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K4A87_RS02465	COG0180	Tryptophanyl-tRNA synthetase
K4A87_RS02515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K4A87_RS02520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K4A87_RS02550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4A87_RS02570	COG0642	Histidine kinase
K4A87_RS02585	COG1090	epimerase
K4A87_RS02620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K4A87_RS02625	COG2011	ABC-type metal ion transport system permease component
K4A87_RS02655	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4A87_RS02665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K4A87_RS02680	COG0356	it plays a direct role in the translocation of protons across the membrane
K4A87_RS02690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K4A87_RS02695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K4A87_RS02715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K4A87_RS02730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K4A87_RS02745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K4A87_RS02785	COG0339	signal peptide processing
K4A87_RS02800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K4A87_RS02805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K4A87_RS02810	COG0546	phosphoglycolate phosphatase activity
K4A87_RS02845	COG1956	GAF domain-containing protein
K4A87_RS02850	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K4A87_RS02860	COG0720	synthase
K4A87_RS02865	COG0513	Belongs to the DEAD box helicase family
K4A87_RS02875	COG0625	glutathione transferase activity
K4A87_RS02910	COG0626	cystathionine gamma-synthase activity
K4A87_RS02925	COG0110	maltose O-acetyltransferase activity
K4A87_RS02930	COG1216	Glycosyl transferase, family 2
K4A87_RS02930	COG0438	transferase activity, transferring glycosyl groups
K4A87_RS02935	COG3754	Rhamnan synthesis protein F
K4A87_RS02965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K4A87_RS02975	COG0300	oxidoreductase activity
K4A87_RS02980	COG0277	FAD linked oxidase domain protein
K4A87_RS02985	COG0546	phosphoglycolate phosphatase activity
K4A87_RS02985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K4A87_RS03000	COG2086	electron transfer activity
K4A87_RS03020	COG1091	dTDP-4-dehydrorhamnose reductase activity
K4A87_RS03025	COG0662	Cupin 2, conserved barrel domain protein
K4A87_RS03025	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K4A87_RS03030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K4A87_RS03065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K4A87_RS03065	COG3218	ABC-type transport auxiliary lipoprotein component
K4A87_RS03070	COG1127	ABC transporter
K4A87_RS03075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K4A87_RS03090	COG0442	prolyl-tRNA aminoacylation
K4A87_RS03105	COG1183	phosphatidylcholine synthase activity
K4A87_RS03120	COG0525	valine-tRNA ligase activity
K4A87_RS03140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K4A87_RS03150	COG0795	lipopolysaccharide-transporting ATPase activity
K4A87_RS03165	COG4974	Belongs to the 'phage' integrase family
K4A87_RS03170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K4A87_RS03180	COG0047	phosphoribosylformylglycinamidine synthase activity
K4A87_RS03180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K4A87_RS03200	COG5295	Hep Hag repeat protein
K4A87_RS03205	COG1404	Belongs to the peptidase S8 family
K4A87_RS03210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K4A87_RS03215	COG1459	type II secretion system
K4A87_RS03225	COG2165	general secretion pathway protein
K4A87_RS03230	COG4970	Tfp pilus assembly protein FimT
K4A87_RS03235	COG2165	general secretion pathway protein
K4A87_RS03240	COG4795	General secretion pathway protein
K4A87_RS03245	COG3156	type II secretion system protein K
K4A87_RS03250	COG3166	PFAM Fimbrial assembly family protein
K4A87_RS03265	COG1450	Type ii and iii secretion system protein
K4A87_RS03290	COG2188	Transcriptional regulator
K4A87_RS03340	COG0242	peptide deformylase activity
K4A87_RS03345	COG0488	(ABC) transporter
K4A87_RS03355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K4A87_RS03370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K4A87_RS03370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K4A87_RS03385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K4A87_RS03395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K4A87_RS03445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K4A87_RS03555	COG0792	nuclease activity
K4A87_RS03600	COG0275	rRNA processing
K4A87_RS03605	COG3116	cell division
K4A87_RS03615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K4A87_RS03620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K4A87_RS03625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K4A87_RS03635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K4A87_RS03640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K4A87_RS03645	COG1181	Belongs to the D-alanine--D-alanine ligase family
K4A87_RS03650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K4A87_RS03675	COG0739	heme binding
K4A87_RS03680	COG0653	protein targeting
K4A87_RS03690	COG0494	nUDIX hydrolase
K4A87_RS03700	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K4A87_RS03710	COG3321	synthase
K4A87_RS03710	COG0604	alcohol dehydrogenase
K4A87_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_RS03795	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K4A87_RS03810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K4A87_RS03820	COG4106	trans-aconitate 2-methyltransferase activity
K4A87_RS03825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K4A87_RS03840	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K4A87_RS03855	COG0642	Histidine kinase
K4A87_RS03870	COG4181	ATPase activity
K4A87_RS03915	COG1560	Kdo2-lipid A biosynthetic process
K4A87_RS03920	COG1519	Transferase
K4A87_RS03925	COG1538	Outer membrane efflux protein
K4A87_RS03930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K4A87_RS03945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K4A87_RS03950	COG0066	3-isopropylmalate dehydratase activity
K4A87_RS03955	COG0473	3-isopropylmalate dehydrogenase activity
K4A87_RS03985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K4A87_RS04005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K4A87_RS04010	COG0840	transmembrane signaling receptor activity
K4A87_RS04035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K4A87_RS04060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K4A87_RS04075	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K4A87_RS04100	COG0563	adenylate kinase activity
K4A87_RS04105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K4A87_RS04120	COG0671	phosphoesterase, PA-phosphatase related
K4A87_RS04140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K4A87_RS04145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K4A87_RS04155	COG0352	thiamine-phosphate diphosphorylase activity
K4A87_RS04160	COG1773	rubredoxin
K4A87_RS04170	COG2912	Transglutaminase-like superfamily
K4A87_RS04190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K4A87_RS04215	COG0006	proline dipeptidase activity
K4A87_RS04220	COG0006	proline dipeptidase activity
K4A87_RS04235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K4A87_RS04240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K4A87_RS04245	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K4A87_RS04250	COG1561	YicC-like family, N-terminal region
K4A87_RS04265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K4A87_RS04275	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K4A87_RS04300	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K4A87_RS04330	COG3385	transposase activity
K4A87_RS04370	COG0714	Associated with various cellular activities
K4A87_RS04390	COG2304	oxidoreductase activity
K4A87_RS04400	COG1301	dicarboxylic acid transport
K4A87_RS04415	COG0739	heme binding
K4A87_RS04420	COG1376	ErfK ybiS ycfS ynhG family protein
K4A87_RS04445	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K4A87_RS04450	COG4149	molybdate abc transporter
K4A87_RS04455	COG0725	ABC transporter, periplasmic molybdate-binding protein
K4A87_RS04460	COG3453	Protein conserved in bacteria
K4A87_RS04460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4A87_RS04470	COG3047	cAMP biosynthetic process
K4A87_RS04475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K4A87_RS04495	COG0469	pyruvate kinase activity
K4A87_RS04500	COG3588	fructose-bisphosphate aldolase
K4A87_RS04505	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K4A87_RS04520	COG0583	DNA-binding transcription factor activity
K4A87_RS04530	COG0784	Response regulator, receiver
K4A87_RS04530	COG2198	Histidine kinase
K4A87_RS04530	COG2205	protein histidine kinase activity
K4A87_RS04555	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K4A87_RS04560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K4A87_RS04570	COG0529	Catalyzes the synthesis of activated sulfate
K4A87_RS04570	COG2895	sulfate adenylyltransferase (ATP) activity
K4A87_RS04575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K4A87_RS04580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K4A87_RS04590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K4A87_RS04605	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K4A87_RS04625	COG1217	gtp-binding protein TYPA
K4A87_RS04630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K4A87_RS04665	COG1902	pentaerythritol trinitrate reductase activity
K4A87_RS04665	COG0446	pyridine nucleotide-disulphide oxidoreductase
K4A87_RS04670	COG0604	alcohol dehydrogenase
K4A87_RS04700	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K4A87_RS04705	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K4A87_RS04710	COG4208	sulfate ABC transporter
K4A87_RS04715	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K4A87_RS04745	COG0406	alpha-ribazole phosphatase activity
K4A87_RS04775	COG0189	ligase activity
K4A87_RS04785	COG0745	RESPONSE REGULATOR receiver
K4A87_RS04830	COG0237	dephospho-CoA kinase activity
K4A87_RS04835	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K4A87_RS04860	COG2184	nucleotidyltransferase activity
K4A87_RS04880	COG0045	succinate-CoA ligase (ADP-forming) activity
K4A87_RS04885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K4A87_RS04895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K4A87_RS04895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K4A87_RS04900	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K4A87_RS04905	COG0564	pseudouridine synthase activity
K4A87_RS04910	COG1496	oxidoreductase activity
K4A87_RS04920	COG3387	PFAM Glycoside hydrolase 15-related
K4A87_RS04925	COG1877	trehalose-phosphatase activity
K4A87_RS04980	COG0542	response to heat
K4A87_RS04990	COG0019	diaminopimelate decarboxylase activity
K4A87_RS05005	COG4264	IucA IucC family
K4A87_RS05015	COG4772	TonB-dependent receptor
K4A87_RS05040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K4A87_RS05040	COG4651	solute:proton antiporter activity
K4A87_RS05065	COG0488	(ABC) transporter
K4A87_RS05085	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K4A87_RS05125	COG2255	four-way junction helicase activity
K4A87_RS05130	COG0824	Thioesterase
K4A87_RS05140	COG0848	biopolymer transport protein
K4A87_RS05150	COG0823	Involved in the tonB-independent uptake of proteins
K4A87_RS05155	COG2885	chlorophyll binding
K4A87_RS05165	COG0602	queuosine metabolic process
K4A87_RS05170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K4A87_RS05200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K4A87_RS05210	COG0544	peptidyl-prolyl cis-trans isomerase activity
K4A87_RS05240	COG2207	Transcriptional regulator
K4A87_RS05240	COG1917	Cupin 2, conserved barrel domain protein
K4A87_RS05245	COG0753	catalase activity
K4A87_RS05250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K4A87_RS05250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K4A87_RS05270	COG2194	sulfuric ester hydrolase activity
K4A87_RS05290	COG0642	Histidine kinase
K4A87_RS05300	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K4A87_RS05305	COG2894	cell division
K4A87_RS05310	COG0850	regulation of cytokinetic process
K4A87_RS05325	COG4585	Histidine kinase
K4A87_RS05330	COG2197	response regulator
K4A87_RS05345	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K4A87_RS05400	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K4A87_RS05415	COG1946	Acyl-CoA thioesterase
K4A87_RS05420	COG1024	Enoyl-CoA hydratase
K4A87_RS05430	COG0824	Thioesterase
K4A87_RS05435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K4A87_RS05445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K4A87_RS05450	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K4A87_RS05465	COG0196	riboflavin kinase activity
K4A87_RS05475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K4A87_RS05480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K4A87_RS05495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K4A87_RS05500	COG1845	cytochrome c oxidase, subunit III
K4A87_RS05505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K4A87_RS05545	COG2207	Transcriptional regulator
K4A87_RS05555	COG4771	TonB-dependent receptor
K4A87_RS05575	COG4191	Histidine kinase
K4A87_RS05575	COG0784	Response regulator, receiver
K4A87_RS05610	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K4A87_RS05620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K4A87_RS05625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K4A87_RS05645	COG1842	Phage shock protein A
K4A87_RS05665	COG5463	Belongs to the UPF0441 family
K4A87_RS05670	COG0754	glutathionylspermidine amidase activity
K4A87_RS05720	COG0531	amino acid
K4A87_RS05725	COG2197	response regulator
K4A87_RS05740	COG1113	amino acid transport
K4A87_RS05775	COG2239	Acts as a magnesium transporter
K4A87_RS05780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K4A87_RS05785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A87_RS05805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A87_RS05820	COG1137	ATPase activity
K4A87_RS05825	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K4A87_RS05835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K4A87_RS05845	COG0271	Belongs to the BolA IbaG family
K4A87_RS05850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K4A87_RS05880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K4A87_RS05885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K4A87_RS05895	COG0628	permease
K4A87_RS05910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K4A87_RS05915	COG3178	'Phosphotransferase
K4A87_RS05930	COG1555	photosystem II stabilization
K4A87_RS05945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K4A87_RS05950	COG1477	protein flavinylation
K4A87_RS05975	COG3128	pkhd-type hydroxylase
K4A87_RS05980	COG4774	siderophore transport
K4A87_RS05990	COG0456	acetyltransferase
K4A87_RS06000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K4A87_RS06005	COG0719	Fe-S assembly protein
K4A87_RS06010	COG0396	ATPase activity
K4A87_RS06015	COG0719	Fe-S assembly protein
K4A87_RS06020	COG1959	2 iron, 2 sulfur cluster binding
K4A87_RS06045	COG4942	peptidase
K4A87_RS06060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K4A87_RS06080	COG1678	Uncharacterized ACR, COG1678
K4A87_RS06085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K4A87_RS06095	COG1764	response to oxidative stress
K4A87_RS06105	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_RS06110	COG0384	phenazine biosynthesis protein PhzF
K4A87_RS06120	COG0527	aspartate kinase activity
K4A87_RS06145	COG0142	geranyltranstransferase activity
K4A87_RS06150	COG0629	single-stranded DNA binding
K4A87_RS06155	COG2203	Gaf domain
K4A87_RS06155	COG3706	GGDEF domain
K4A87_RS06155	COG4251	negative regulation of phosphorylation
K4A87_RS06155	COG5001	Diguanylate cyclase
K4A87_RS06165	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K4A87_RS06175	COG0746	molybdenum cofactor guanylyltransferase activity
K4A87_RS06185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K4A87_RS06190	COG2879	small protein
K4A87_RS06195	COG1966	Carbon starvation protein
K4A87_RS06215	COG0588	phosphoglycerate mutase activity
K4A87_RS06260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K4A87_RS06265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K4A87_RS06280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K4A87_RS06335	COG0438	transferase activity, transferring glycosyl groups
K4A87_RS06340	COG0438	transferase activity, transferring glycosyl groups
K4A87_RS06350	COG0438	transferase activity, transferring glycosyl groups
K4A87_RS06380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K4A87_RS06390	COG1960	acyl-CoA dehydrogenase activity
K4A87_RS06400	COG3040	lipid binding
K4A87_RS06415	COG3039	Transposase
K4A87_RS06465	COG0326	Molecular chaperone. Has ATPase activity
K4A87_RS06470	COG0742	ribosomal rna small subunit methyltransferase
K4A87_RS06475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K4A87_RS06485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K4A87_RS06490	COG0405	Gamma-glutamyltransferase
K4A87_RS06495	COG3291	Pkd domain containing protein
K4A87_RS06535	COG3039	Transposase
K4A87_RS06625	COG2963	transposase activity
K4A87_RS06650	COG0784	Response regulator, receiver
K4A87_RS06650	COG2205	protein histidine kinase activity
K4A87_RS06650	COG5002	protein histidine kinase activity
K4A87_RS06655	COG2733	membrane
K4A87_RS06665	COG1121	(ABC) transporter
K4A87_RS06670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K4A87_RS06680	COG2223	nitrite transmembrane transporter activity
K4A87_RS06685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K4A87_RS06690	COG0243	molybdopterin cofactor binding
K4A87_RS06700	COG0477	Major facilitator Superfamily
K4A87_RS06710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K4A87_RS06715	COG0174	glutamine synthetase
K4A87_RS06755	COG3842	ATPase activity
K4A87_RS06760	COG1176	ABC-type spermidine putrescine transport system, permease component I
K4A87_RS06765	COG1177	transmembrane transport
K4A87_RS06770	COG1012	belongs to the aldehyde dehydrogenase family
K4A87_RS06790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K4A87_RS06795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K4A87_RS06805	COG2902	Dehydrogenase
K4A87_RS06890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K4A87_RS06940	COG4133	protoheme IX ABC transporter activity
K4A87_RS06945	COG0436	Aminotransferase
K4A87_RS06970	COG1187	pseudouridine synthase activity
K4A87_RS06975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K4A87_RS06980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K4A87_RS06985	COG2350	Protein conserved in bacteria
K4A87_RS07020	COG1175	transmembrane transport
K4A87_RS07025	COG0395	ABC-type sugar transport system, permease component
K4A87_RS07050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K4A87_RS07055	COG2957	Belongs to the agmatine deiminase family
K4A87_RS07065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K4A87_RS07070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K4A87_RS07075	COG0539	negative regulation of cytoplasmic translation
K4A87_RS07090	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K4A87_RS07095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K4A87_RS07120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K4A87_RS07170	COG4691	Plasmid stability protein
K4A87_RS07175	COG1487	ribonuclease activity
K4A87_RS07180	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_RS07195	COG3039	Transposase
K4A87_RS07205	COG3737	Protein of unknown function (DUF498/DUF598)
K4A87_RS07210	COG1534	Rna-binding protein
K4A87_RS07215	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K4A87_RS07225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K4A87_RS07230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K4A87_RS07240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K4A87_RS07245	COG1546	Belongs to the CinA family
K4A87_RS07265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K4A87_RS07270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K4A87_RS07280	COG2137	regulation of response to DNA damage stimulus
K4A87_RS07285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K4A87_RS07290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K4A87_RS07305	COG1741	Belongs to the pirin family
K4A87_RS07310	COG0583	DNA-binding transcription factor activity
K4A87_RS07335	COG0352	thiamine-phosphate diphosphorylase activity
K4A87_RS07335	COG0351	phosphomethylpyrimidine kinase
K4A87_RS07345	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K4A87_RS07350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K4A87_RS07365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K4A87_RS07375	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K4A87_RS07380	COG3734	2-keto-3-deoxy-galactonokinase
K4A87_RS07390	COG4948	Mandelate Racemase Muconate Lactonizing
K4A87_RS07395	COG0800	Aldolase
K4A87_RS07445	COG1501	Belongs to the glycosyl hydrolase 31 family
K4A87_RS07455	COG1070	Carbohydrate kinase
K4A87_RS07465	COG0477	Major facilitator Superfamily
K4A87_RS07490	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K4A87_RS07495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K4A87_RS07500	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K4A87_RS07505	COG0166	Belongs to the GPI family
K4A87_RS07550	COG1472	Belongs to the glycosyl hydrolase 3 family
K4A87_RS07590	COG5001	Diguanylate cyclase
K4A87_RS07590	COG4251	negative regulation of phosphorylation
K4A87_RS07590	COG3706	GGDEF domain
K4A87_RS07590	COG2203	Gaf domain
K4A87_RS07610	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K4A87_RS07615	COG0671	phosphoesterase, PA-phosphatase related
K4A87_RS07625	COG0697	spore germination
K4A87_RS07630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K4A87_RS07635	COG0167	dihydroorotate dehydrogenase activity
K4A87_RS07650	COG1012	belongs to the aldehyde dehydrogenase family
K4A87_RS07715	COG2003	Belongs to the UPF0758 family
K4A87_RS07835	COG2814	Major facilitator Superfamily
K4A87_RS07895	COG0527	aspartate kinase activity
K4A87_RS07895	COG0460	homoserine dehydrogenase
K4A87_RS07930	COG0124	histidyl-tRNA synthetase
K4A87_RS07940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K4A87_RS07945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K4A87_RS07950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K4A87_RS07955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K4A87_RS07955	COG0131	Imidazoleglycerol-phosphate dehydratase
K4A87_RS07960	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K4A87_RS07965	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K4A87_RS07970	COG0107	imidazoleglycerol-phosphate synthase activity
K4A87_RS07975	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K4A87_RS07975	COG0140	phosphoribosyl-ATP diphosphatase activity
K4A87_RS08015	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
K4A87_RS08020	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K4A87_RS08030	COG0531	amino acid
K4A87_RS08035	COG0531	amino acid
K4A87_RS08045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K4A87_RS08050	COG0277	FAD linked oxidase domain protein
K4A87_RS08065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K4A87_RS08080	COG1024	Enoyl-CoA hydratase
K4A87_RS08120	COG0505	Belongs to the CarA family
K4A87_RS08135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K4A87_RS08140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K4A87_RS08150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K4A87_RS08170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K4A87_RS08185	COG2205	protein histidine kinase activity
K4A87_RS08185	COG0784	Response regulator, receiver
K4A87_RS08185	COG2198	Histidine kinase
K4A87_RS08190	COG1024	Enoyl-CoA hydratase
K4A87_RS08200	COG0318	PFAM AMP-dependent synthetase and ligase
K4A87_RS08230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K4A87_RS08260	COG0835	chemotaxis
K4A87_RS08275	COG0840	transmembrane signaling receptor activity
K4A87_RS08285	COG0840	transmembrane signaling receptor activity
K4A87_RS08295	COG0840	transmembrane signaling receptor activity
K4A87_RS08305	COG0840	transmembrane signaling receptor activity
K4A87_RS08310	COG0840	transmembrane signaling receptor activity
K4A87_RS08330	COG2198	Histidine kinase
K4A87_RS08330	COG0643	Histidine kinase
K4A87_RS08335	COG0745	RESPONSE REGULATOR receiver
K4A87_RS08345	COG0835	chemotaxis
K4A87_RS08350	COG1192	Involved in chromosome partitioning
K4A87_RS08355	COG1360	Flagellar Motor Protein
K4A87_RS08360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K4A87_RS08385	COG0643	Histidine kinase
K4A87_RS08385	COG0784	Response regulator, receiver
K4A87_RS08385	COG2198	Histidine kinase
K4A87_RS08430	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_RS08475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K4A87_RS08495	COG1684	flagellar biosynthetic protein fliR
K4A87_RS08570	COG1677	Flagellar hook-basal body complex protein FliE
K4A87_RS08595	COG2201	protein-glutamate methylesterase activity
K4A87_RS08605	COG2197	response regulator
K4A87_RS08625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K4A87_RS08630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K4A87_RS08645	COG1705	Flagellar rod assembly protein muramidase FlgJ
K4A87_RS08645	COG3951	Flagellar rod assembly protein muramidase FlgJ
K4A87_RS08650	COG1706	bacterial-type flagellum-dependent cell motility
K4A87_RS08665	COG4787	bacterial-type flagellum-dependent cell motility
K4A87_RS08675	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K4A87_RS08680	COG1558	bacterial-type flagellum-dependent cell motility
K4A87_RS08695	COG0784	Response regulator, receiver
K4A87_RS08695	COG0835	chemotaxis
K4A87_RS08715	COG5002	protein histidine kinase activity
K4A87_RS08730	COG4585	Histidine kinase
K4A87_RS08755	COG2915	High frequency lysogenization protein hflD homolog
K4A87_RS08760	COG0482	sulfurtransferase activity
K4A87_RS08780	COG0542	response to heat
K4A87_RS08790	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K4A87_RS08800	COG0492	ferredoxin-NADP+ reductase activity
K4A87_RS08805	COG1674	ftsk spoiiie
K4A87_RS08820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K4A87_RS08825	COG0038	chloride channel
K4A87_RS08830	COG0183	Belongs to the thiolase family
K4A87_RS08835	COG1024	Enoyl-CoA hydratase
K4A87_RS08835	COG1250	3-hydroxyacyl-CoA dehydrogenase
K4A87_RS08850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K4A87_RS08870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K4A87_RS08875	COG1160	GTP binding
K4A87_RS08880	COG0303	'Molybdopterin
K4A87_RS08885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K4A87_RS08905	COG0303	'Molybdopterin
K4A87_RS08910	COG0746	molybdenum cofactor guanylyltransferase activity
K4A87_RS08920	COG1648	precorrin-2 dehydrogenase activity
K4A87_RS08920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K4A87_RS08935	COG3685	Protein conserved in bacteria
K4A87_RS08990	COG1064	alcohol dehydrogenase
K4A87_RS09220	COG2154	pterin-4-alpha-carbinolamine dehydratase
K4A87_RS09240	COG0564	pseudouridine synthase activity
K4A87_RS09245	COG1530	ribonuclease E activity
K4A87_RS09265	COG1304	FMN binding
K4A87_RS09275	COG1657	PFAM Prenyltransferase squalene oxidase
K4A87_RS09280	COG0142	geranyltranstransferase activity
K4A87_RS09285	COG2124	cytochrome p450
K4A87_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_RS09295	COG1141	Ferredoxin
K4A87_RS09300	COG2124	cytochrome p450
K4A87_RS09305	COG2124	cytochrome p450
K4A87_RS09325	COG2951	lytic endotransglycosylase activity
K4A87_RS09340	COG1054	Belongs to the UPF0176 family
K4A87_RS09365	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K4A87_RS09385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4A87_RS09420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K4A87_RS09425	COG0322	excinuclease ABC activity
K4A87_RS09435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K4A87_RS09440	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K4A87_RS09445	COG1663	tetraacyldisaccharide 4'-kinase activity
K4A87_RS09450	COG1132	(ABC) transporter
K4A87_RS09455	COG0848	biopolymer transport protein
K4A87_RS09460	COG0811	peptide transport
K4A87_RS09475	COG1136	(ABC) transporter
K4A87_RS09480	COG4591	ABC-type transport system involved in lipoprotein release permease component
K4A87_RS09490	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K4A87_RS09495	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K4A87_RS09510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K4A87_RS09535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K4A87_RS09550	COG0129	dihydroxy-acid dehydratase activity
K4A87_RS09555	COG0800	Aldolase
K4A87_RS09620	COG0784	Response regulator, receiver
K4A87_RS09620	COG2198	Histidine kinase
K4A87_RS09620	COG2205	protein histidine kinase activity
K4A87_RS09625	COG2183	response to ionizing radiation
K4A87_RS09650	COG3243	poly(R)-hydroxyalkanoic acid synthase
K4A87_RS09685	COG0668	transmembrane transport
K4A87_RS09705	COG1914	H( )-stimulated, divalent metal cation uptake system
K4A87_RS09750	COG1238	metal cluster binding
K4A87_RS09755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K4A87_RS09760	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K4A87_RS09765	COG2840	Smr protein MutS2
K4A87_RS09775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K4A87_RS09780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K4A87_RS09790	COG0148	phosphopyruvate hydratase activity
K4A87_RS09795	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K4A87_RS09800	COG0504	CTP synthase activity
K4A87_RS09820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K4A87_RS09835	COG1253	flavin adenine dinucleotide binding
K4A87_RS09850	COG2271	Major facilitator Superfamily
K4A87_RS09935	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K4A87_RS09950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K4A87_RS09955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K4A87_RS09960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K4A87_RS09970	COG2890	protein-(glutamine-N5) methyltransferase activity
K4A87_RS10025	COG1228	amidohydrolase
K4A87_RS10030	COG2986	histidine ammonia-lyase
K4A87_RS10040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K4A87_RS10065	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K4A87_RS10080	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K4A87_RS10085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K4A87_RS10120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K4A87_RS10130	COG0316	Belongs to the HesB IscA family
K4A87_RS10135	COG0017	Asparaginyl-tRNA synthetase
K4A87_RS10160	COG0288	reversible hydration of carbon dioxide
K4A87_RS10175	COG3844	kynureninase activity
K4A87_RS10180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K4A87_RS10185	COG2925	Exonuclease
K4A87_RS10205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K4A87_RS10210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K4A87_RS10210	COG0116	Belongs to the methyltransferase superfamily
K4A87_RS10250	COG0494	nUDIX hydrolase
K4A87_RS10270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K4A87_RS10275	COG0659	secondary active sulfate transmembrane transporter activity
K4A87_RS10305	COG0573	inorganic phosphate transmembrane transporter activity
K4A87_RS10310	COG0581	inorganic phosphate transmembrane transporter activity
K4A87_RS10315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K4A87_RS10320	COG0704	Plays a role in the regulation of phosphate uptake
K4A87_RS10325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K4A87_RS10340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K4A87_RS10345	COG0557	exoribonuclease II activity
K4A87_RS10360	COG1960	acyl-CoA dehydrogenase activity
K4A87_RS10365	COG2226	methyltransferase
K4A87_RS10370	COG0646	methionine synthase
K4A87_RS10370	COG1410	methionine synthase
K4A87_RS10375	COG0646	methionine synthase
K4A87_RS10375	COG1410	methionine synthase
K4A87_RS10385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4A87_RS10395	COG1609	Transcriptional regulator
K4A87_RS10410	COG2900	Belongs to the SlyX family
K4A87_RS10425	COG0386	Belongs to the glutathione peroxidase family
K4A87_RS10430	COG1725	Transcriptional regulator
K4A87_RS10435	COG1131	(ABC) transporter
K4A87_RS10495	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_RS10505	COG2850	peptidyl-arginine hydroxylation
K4A87_RS10540	COG1132	(ABC) transporter
K4A87_RS10575	COG1605	Chorismate mutase
K4A87_RS10575	COG0287	Prephenate dehydrogenase
K4A87_RS10580	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K4A87_RS10585	COG0484	heat shock protein binding
K4A87_RS10595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K4A87_RS10605	COG0497	DNA recombination
K4A87_RS10615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K4A87_RS10620	COG2914	Belongs to the UPF0125 (RnfH) family
K4A87_RS10630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K4A87_RS10780	COG3702	type iv secretory pathway
K4A87_RS10800	COG2948	multi-organism process
K4A87_RS10830	COG0556	nucleotide-excision repair
K4A87_RS10905	COG0165	Argininosuccinate lyase
K4A87_RS10920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K4A87_RS10925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K4A87_RS10930	COG0137	argininosuccinate synthase activity
K4A87_RS10935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K4A87_RS10950	COG2166	iron-sulfur cluster assembly
K4A87_RS10975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K4A87_RS11015	COG0402	S-adenosylhomocysteine deaminase activity
K4A87_RS11030	COG1509	lysine 2,3-aminomutase activity
K4A87_RS11040	COG0483	inositol monophosphate 1-phosphatase activity
K4A87_RS11045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K4A87_RS11060	COG0488	(ABC) transporter
K4A87_RS11065	COG0513	Belongs to the DEAD box helicase family
K4A87_RS11070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K4A87_RS11075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K4A87_RS11085	COG0625	glutathione transferase activity
K4A87_RS11095	COG4681	YaeQ
K4A87_RS11100	COG2081	HI0933 family
K4A87_RS11110	COG0501	Belongs to the peptidase M48B family
K4A87_RS11115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K4A87_RS11120	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_RS11140	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K4A87_RS11145	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4A87_RS11155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K4A87_RS11155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K4A87_RS11160	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K4A87_RS11175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K4A87_RS11210	COG2094	Belongs to the DNA glycosylase MPG family
K4A87_RS11225	COG2969	positive regulation of protein catabolic process
K4A87_RS11230	COG0625	glutathione transferase activity
K4A87_RS11235	COG2857	Cytochrome c1
K4A87_RS11240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K4A87_RS11245	COG0723	plastoquinol--plastocyanin reductase activity
K4A87_RS11250	COG0741	lytic transglycosylase activity
K4A87_RS11280	COG0415	Belongs to the DNA photolyase family
K4A87_RS11285	COG0305	Participates in initiation and elongation during chromosome replication
K4A87_RS11295	COG0367	asparagine synthase
K4A87_RS11330	COG0084	hydrolase, TatD family'
K4A87_RS11335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K4A87_RS11400	COG0386	Belongs to the glutathione peroxidase family
K4A87_RS11470	COG2814	Major facilitator Superfamily
K4A87_RS11475	COG1566	PFAM secretion protein HlyD family protein
K4A87_RS11520	COG0367	asparagine synthase
K4A87_RS11525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K4A87_RS11535	COG1393	Belongs to the ArsC family
K4A87_RS11550	COG0024	Methionine aminopeptidase
K4A87_RS11585	COG0052	Belongs to the universal ribosomal protein uS2 family
K4A87_RS11590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K4A87_RS11600	COG0528	UMP kinase activity
K4A87_RS11605	COG0233	cytoplasmic translational termination
K4A87_RS11615	COG0575	Belongs to the CDS family
K4A87_RS11620	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K4A87_RS11625	COG0750	zinc metalloprotease
K4A87_RS11640	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K4A87_RS11650	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K4A87_RS11655	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K4A87_RS11670	COG0825	malonyl-CoA metabolic process
K4A87_RS11675	COG1981	membrane
K4A87_RS11705	COG5599	Phosphatase
K4A87_RS11725	COG3039	Transposase
K4A87_RS11800	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_RS11825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K4A87_RS11855	COG0531	amino acid
K4A87_RS11870	COG0006	proline dipeptidase activity
K4A87_RS11880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K4A87_RS11895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K4A87_RS11900	COG3938	Belongs to the proline racemase family
K4A87_RS11910	COG0552	protein localization to endoplasmic reticulum
K4A87_RS11925	COG3039	Transposase
K4A87_RS11985	COG0583	DNA-binding transcription factor activity
K4A87_RS12010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K4A87_RS12015	COG0077	Prephenate dehydratase
K4A87_RS12015	COG1605	Chorismate mutase
K4A87_RS12020	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K4A87_RS12025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K4A87_RS12035	COG1609	Transcriptional regulator
K4A87_RS12040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K4A87_RS12040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A87_RS12045	COG1105	Belongs to the carbohydrate kinase PfkB family
K4A87_RS12050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4A87_RS12050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4A87_RS12065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K4A87_RS12070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K4A87_RS12075	COG1862	Preprotein translocase
K4A87_RS12085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K4A87_RS12110	COG1702	phosphate starvation-inducible protein PhoH
K4A87_RS12115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K4A87_RS12125	COG4535	Mg2 and Co2 transporter CorC
K4A87_RS12150	COG2003	Belongs to the UPF0758 family
K4A87_RS12155	COG0688	phosphatidylethanolamine metabolic process
K4A87_RS12165	COG3220	belongs to the UPF0276 family
K4A87_RS12180	COG0840	transmembrane signaling receptor activity
K4A87_RS12225	COG3275	phosphorelay sensor kinase activity
K4A87_RS12240	COG1611	Belongs to the LOG family
K4A87_RS12250	COG2095	MarC family integral membrane protein
K4A87_RS12260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K4A87_RS12305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K4A87_RS12315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K4A87_RS12320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K4A87_RS12325	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K4A87_RS12330	COG0195	Participates in both transcription termination and antitermination
K4A87_RS12335	COG0779	Required for maturation of 30S ribosomal subunits
K4A87_RS12345	COG1007	ATP synthesis coupled electron transport
K4A87_RS12370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K4A87_RS12385	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K4A87_RS12390	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K4A87_RS12395	COG0649	NAD binding
K4A87_RS12410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K4A87_RS12460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K4A87_RS12480	COG0133	tryptophan synthase activity
K4A87_RS12500	COG0101	tRNA pseudouridine synthase activity
K4A87_RS12520	COG0433	COG0433 Predicted ATPase
K4A87_RS12535	COG5487	UPF0391 membrane protein
K4A87_RS12570	COG0183	Belongs to the thiolase family
K4A87_RS12600	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K4A87_RS12600	COG1793	dna ligase
K4A87_RS12610	COG1793	dna ligase
K4A87_RS12615	COG1201	RNA secondary structure unwinding
K4A87_RS12625	COG1278	Cold shock
K4A87_RS12630	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K4A87_RS12635	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K4A87_RS12640	COG1472	Belongs to the glycosyl hydrolase 3 family
K4A87_RS12645	COG3046	protein related to deoxyribodipyrimidine photolyase
K4A87_RS12650	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
K4A87_RS12655	COG2954	triphosphatase activity
K4A87_RS12670	COG1381	Involved in DNA repair and RecF pathway recombination
K4A87_RS12685	COG0571	ribonuclease III activity
K4A87_RS12700	COG0481	GTPase activity
K4A87_RS12715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4A87_RS12730	COG1024	Enoyl-CoA hydratase
K4A87_RS12730	COG1250	3-hydroxyacyl-CoA dehydrogenase
K4A87_RS12745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K4A87_RS12750	COG1024	Enoyl-CoA hydratase
K4A87_RS12755	COG1960	acyl-CoA dehydrogenase activity
K4A87_RS12825	COG2198	Histidine kinase
K4A87_RS12825	COG0643	Histidine kinase
K4A87_RS12835	COG0835	chemotaxis
K4A87_RS12840	COG2199	diguanylate cyclase activity
K4A87_RS12840	COG2200	EAL domain
K4A87_RS12840	COG2202	Pas domain
K4A87_RS12845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K4A87_RS12885	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K4A87_RS12900	COG2040	homocysteine
K4A87_RS12905	COG0833	amino acid
K4A87_RS12915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4A87_RS12915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4A87_RS12925	COG2878	Part of a membrane complex involved in electron transport
K4A87_RS12940	COG1595	DNA-templated transcription, initiation
K4A87_RS12965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K4A87_RS12980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K4A87_RS12990	COG0251	oxidation-reduction process
K4A87_RS13000	COG0392	lysyltransferase activity
K4A87_RS13000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K4A87_RS13030	COG2814	Major facilitator Superfamily
K4A87_RS13070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K4A87_RS13095	COG0412	Dienelactone hydrolase
K4A87_RS13115	COG0717	Belongs to the dCTP deaminase family
K4A87_RS13120	COG0489	protein tyrosine kinase activity
K4A87_RS13155	COG3590	peptidase
K4A87_RS13190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K4A87_RS13195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K4A87_RS13200	COG2311	Membrane
K4A87_RS13205	COG1047	Peptidyl-prolyl cis-trans
K4A87_RS13210	COG0791	NLP P60 protein
K4A87_RS13215	COG0791	NLP P60 protein
K4A87_RS13230	COG1301	dicarboxylic acid transport
K4A87_RS13235	COG1785	Belongs to the alkaline phosphatase family
K4A87_RS13240	COG0037	tRNA processing
K4A87_RS13245	COG1722	exodeoxyribonuclease VII activity
K4A87_RS13250	COG0142	geranyltranstransferase activity
K4A87_RS13265	COG0312	modulator of DNA gyrase
K4A87_RS13270	COG3028	Belongs to the UPF0307 family
K4A87_RS13275	COG0312	modulator of DNA gyrase
K4A87_RS13285	COG3164	Protein of unknown function
K4A87_RS13295	COG0424	maF-like protein
K4A87_RS13300	COG2968	Membrane
K4A87_RS13335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K4A87_RS13350	COG0495	leucyl-tRNA aminoacylation
K4A87_RS13360	COG3118	belongs to the thioredoxin family
K4A87_RS13430	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K4A87_RS13485	COG5297	Belongs to the glycosyl hydrolase family 6
K4A87_RS13510	COG2155	Conserved Protein
K4A87_RS13545	COG1132	(ABC) transporter
K4A87_RS13555	COG0475	glutathione-regulated potassium exporter activity
K4A87_RS13580	COG1187	pseudouridine synthase activity
K4A87_RS13590	COG5002	protein histidine kinase activity
K4A87_RS13590	COG5001	Diguanylate cyclase
K4A87_RS13680	COG1404	Belongs to the peptidase S8 family
K4A87_RS13710	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K4A87_RS13715	COG0735	belongs to the Fur family
K4A87_RS13720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K4A87_RS13760	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K4A87_RS13770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K4A87_RS13815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K4A87_RS13825	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K4A87_RS13840	COG0534	Mate efflux family protein
K4A87_RS13850	COG0336	Belongs to the RNA methyltransferase TrmD family
K4A87_RS13855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K4A87_RS13885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K4A87_RS13890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K4A87_RS13915	COG2353	YceI-like domain
K4A87_RS13945	COG0460	homoserine dehydrogenase
K4A87_RS13945	COG0527	aspartate kinase activity
K4A87_RS13950	COG0626	cystathionine gamma-synthase activity
K4A87_RS13955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K4A87_RS13965	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K4A87_RS13970	COG1272	protein, Hemolysin III
K4A87_RS13975	COG2982	Protein involved in outer membrane biogenesis
K4A87_RS13980	COG0517	IMP dehydrogenase activity
K4A87_RS13980	COG0516	GMP reductase activity
K4A87_RS13985	COG0463	Glycosyl transferase, family 2
K4A87_RS13990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K4A87_RS13995	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K4A87_RS14005	COG1309	transcriptional regulator
K4A87_RS14015	COG1960	acyl-CoA dehydrogenase activity
K4A87_RS14045	COG0509	glycine decarboxylation via glycine cleavage system
K4A87_RS14050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K4A87_RS14060	COG3956	TIGRFAM MazG family protein
K4A87_RS14065	COG1218	3'(2'),5'-bisphosphate nucleotidase
K4A87_RS14070	COG0494	nUDIX hydrolase
K4A87_RS14080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K4A87_RS14120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K4A87_RS14130	COG1309	transcriptional regulator
K4A87_RS14155	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_RS14195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K4A87_RS14205	COG0330	HflC and HflK could
K4A87_RS14210	COG0330	HflC and HflK could
K4A87_RS14235	COG0678	peroxiredoxin activity
K4A87_RS14260	COG0346	lactoylglutathione lyase activity
K4A87_RS14285	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K4A87_RS14290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K4A87_RS14315	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_RS14350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K4A87_RS14365	COG3829	transcription factor binding
K4A87_RS14400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K4A87_RS14405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K4A87_RS14420	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_RS14425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K4A87_RS14430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K4A87_RS14440	COG1399	metal-binding, possibly nucleic acid-binding protein
K4A87_RS14445	COG0424	maF-like protein
K4A87_RS14465	COG0714	Associated with various cellular activities
K4A87_RS14485	COG0537	adenosine 5'-monophosphoramidase activity
K4A87_RS14495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K4A87_RS14585	COG0314	molybdopterin synthase activity
K4A87_RS14595	COG0315	cyclic pyranopterin monophosphate synthase activity
K4A87_RS14605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K4A87_RS14610	COG1234	tRNA 3'-trailer cleavage
K4A87_RS14615	COG3642	lipopolysaccharide core region biosynthetic process
K4A87_RS14620	COG0859	PFAM glycosyl transferase family 9
K4A87_RS14635	COG0631	protein serine/threonine phosphatase activity
K4A87_RS14645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K4A87_RS14660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4A87_RS14665	COG3942	CHAP domain
K4A87_RS14665	COG1388	LysM domain
K4A87_RS14675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K4A87_RS14680	COG3039	Transposase
K4A87_RS14690	COG0823	Involved in the tonB-independent uptake of proteins
K4A87_RS14690	COG1506	peptidase
K4A87_RS14720	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_RS14750	COG1297	OPT oligopeptide transporter protein
K4A87_RS14775	COG2080	2 iron, 2 sulfur cluster binding
K4A87_RS14780	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K4A87_RS14785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K4A87_RS14790	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_RS14840	COG0837	glucose binding
K4A87_RS14860	COG3858	chitin binding
K4A87_RS14860	COG1388	LysM domain
K4A87_RS14865	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K4A87_RS14875	COG1472	Belongs to the glycosyl hydrolase 3 family
K4A87_RS14925	COG3537	Alpha-1,2-mannosidase
K4A87_RS14980	COG3645	SOS response
K4A87_RS14995	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K4A87_RS15030	COG3142	Participates in the control of copper homeostasis
K4A87_RS15055	COG2201	protein-glutamate methylesterase activity
K4A87_RS15065	COG0840	transmembrane signaling receptor activity
K4A87_RS15070	COG0835	chemotaxis
K4A87_RS15085	COG0189	ligase activity
K4A87_RS15105	COG1199	ATP-dependent helicase activity
K4A87_RS15115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K4A87_RS15120	COG1215	transferase activity, transferring glycosyl groups
K4A87_RS15130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K4A87_RS15140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K4A87_RS15145	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
K4A87_RS15155	COG0535	radical SAM domain protein
K4A87_RS15180	COG1643	Atp-dependent helicase
K4A87_RS15185	COG0783	Belongs to the Dps family
K4A87_RS15230	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4A87_RS15270	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K4A87_RS15335	COG0473	3-isopropylmalate dehydrogenase activity
K4A87_RS15350	COG4783	chaperone-mediated protein folding
K4A87_RS15370	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K4A87_RS15380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K4A87_RS15380	COG0438	transferase activity, transferring glycosyl groups
K4A87_RS15385	COG0671	phosphoesterase, PA-phosphatase related
K4A87_RS15390	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K4A87_RS15405	COG2833	Protein of unknown function (DUF455)
K4A87_RS15425	COG0285	dihydrofolate synthase activity
K4A87_RS15445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K4A87_RS15490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K4A87_RS15495	COG0471	metal ion transport
K4A87_RS15495	COG3273	potassium ion transport
K4A87_RS15515	COG1970	mechanosensitive ion channel activity
K4A87_RS15555	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K4A87_RS15565	COG0203	ribosomal protein L17
K4A87_RS15590	COG0201	protein transport
K4A87_RS15595	COG0200	Binds to the 23S rRNA
K4A87_RS15600	COG1841	ribosomal large subunit assembly
K4A87_RS15635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K4A87_RS15645	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K4A87_RS15650	COG0255	Belongs to the universal ribosomal protein uL29 family
K4A87_RS15665	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K4A87_RS15675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K4A87_RS15690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K4A87_RS15695	COG0051	transcription antitermination factor activity, RNA binding
K4A87_RS15700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K4A87_RS15705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K4A87_RS15715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K4A87_RS15720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K4A87_RS15730	COG0222	ribosome binding
K4A87_RS15735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K4A87_RS15740	COG0081	regulation of translation
K4A87_RS15750	COG0250	Participates in transcription elongation, termination and antitermination
K4A87_RS15755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K4A87_RS15765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K4A87_RS15785	COG0012	GTP binding
K4A87_RS15790	COG0193	aminoacyl-tRNA hydrolase activity
K4A87_RS15795	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K4A87_RS15800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K4A87_RS15810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K4A87_RS15815	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K4A87_RS15825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K4A87_RS15830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K4A87_RS15840	COG0521	Mo-molybdopterin cofactor biosynthetic process
K4A87_RS15860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4A87_RS15865	COG1295	ribonuclease BN
K4A87_RS15890	COG1404	Belongs to the peptidase S8 family
K4A87_RS15900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K4A87_RS15950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K4A87_RS15950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K4A87_RS15970	COG2890	protein-(glutamine-N5) methyltransferase activity
K4A87_RS15980	COG3634	alkyl hydroperoxide reductase activity
K4A87_RS15985	COG0583	DNA-binding transcription factor activity
K4A87_RS15995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K4A87_RS16000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K4A87_RS16015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K4A87_RS16035	COG0673	inositol 2-dehydrogenase activity
K4A87_RS16040	COG3386	PFAM SMP-30 Gluconolaconase
K4A87_RS16060	COG0583	DNA-binding transcription factor activity
K4A87_RS16075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K4A87_RS16080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K4A87_RS16090	COG2096	Adenosyltransferase
K4A87_RS16095	COG0123	including yeast histone deacetylase and acetoin utilization protein
K4A87_RS16100	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K4A87_RS16110	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K4A87_RS16115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K4A87_RS16120	COG2967	ApaG domain
K4A87_RS16125	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K4A87_RS16145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K4A87_RS16165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K4A87_RS16200	COG0280	phosphate acetyltransferase
K4A87_RS16200	COG0281	malic enzyme
K4A87_RS16275	COG0642	Histidine kinase
K4A87_RS16290	COG2851	Citrate transporter
K4A87_RS16295	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_RS16310	COG2211	Major facilitator Superfamily
K4A87_RS16360	COG0436	Aminotransferase
K4A87_RS16385	COG0726	polysaccharide deacetylase
K4A87_RS16390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K4A87_RS16450	COG3920	Histidine kinase
K4A87_RS16455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K4A87_RS16460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K4A87_RS16465	COG1609	Transcriptional regulator
K4A87_RS16475	COG2188	Transcriptional regulator
K4A87_RS16545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K4A87_RS16550	COG4191	Histidine kinase
K4A87_RS16555	COG0784	Response regulator, receiver
K4A87_RS16560	COG4251	negative regulation of phosphorylation
K4A87_RS16570	COG2823	Periplasmic or secreted lipoprotein
K4A87_RS16575	COG0673	inositol 2-dehydrogenase activity
K4A87_RS16580	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K4A87_RS16675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K4A87_RS16685	COG2921	Belongs to the UPF0250 family
K4A87_RS16695	COG1686	Belongs to the peptidase S11 family
K4A87_RS16700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K4A87_RS16705	COG2951	lytic endotransglycosylase activity
K4A87_RS16715	COG0772	Belongs to the SEDS family
K4A87_RS16730	COG1792	Involved in formation and maintenance of cell shape
K4A87_RS16735	COG1077	Cell shape determining protein MreB Mrl
K4A87_RS16740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4A87_RS16760	COG0308	aminopeptidase N
K4A87_RS16765	COG3300	MHYT domain
K4A87_RS16765	COG5001	Diguanylate cyclase
K4A87_RS16770	COG2226	methyltransferase
K4A87_RS16795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K4A87_RS16800	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K4A87_RS16805	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K4A87_RS16815	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K4A87_RS16825	COG2832	Protein of unknown function (DUF454)
K4A87_RS16860	COG0436	Aminotransferase
K4A87_RS16875	COG1505	serine-type exopeptidase activity
K4A87_RS16900	COG0181	hydroxymethylbilane synthase activity
K4A87_RS16920	COG2943	transferase activity, transferring hexosyl groups
K4A87_RS16935	COG0659	secondary active sulfate transmembrane transporter activity
K4A87_RS16940	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K4A87_RS16940	COG5297	Belongs to the glycosyl hydrolase family 6
K4A87_RS16995	COG1113	amino acid transport
K4A87_RS17000	COG4305	rare lipoprotein A
K4A87_RS17015	COG0697	spore germination
K4A87_RS17095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K4A87_RS17100	COG0511	ligase activity, forming carbon-carbon bonds
K4A87_RS17110	COG0439	Biotin carboxylase
K4A87_RS17115	COG2264	protein methyltransferase activity
K4A87_RS17140	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K4A87_RS17165	COG0138	bifunctional purine biosynthesis protein purh
K4A87_RS17170	COG0151	Belongs to the GarS family
K4A87_RS17175	COG3039	Transposase
K4A87_RS17200	COG1289	transmembrane transporter activity
K4A87_RS17205	COG2814	Major facilitator Superfamily
K4A87_RS17215	COG2814	Major facilitator Superfamily
K4A87_RS17230	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K4A87_RS17235	COG2816	NAD+ diphosphatase activity
K4A87_RS17240	COG0316	Belongs to the HesB IscA family
K4A87_RS17300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K4A87_RS17310	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K4A87_RS17325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K4A87_RS17335	COG0134	indole-3-glycerol-phosphate synthase activity
K4A87_RS17340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K4A87_RS17375	COG1597	lipid kinase activity
K4A87_RS17380	COG0456	acetyltransferase
K4A87_RS17395	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K4A87_RS17430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K4A87_RS17430	COG2111	Na H antiporter
K4A87_RS17435	COG1006	Multisubunit Na H antiporter MnhC subunit
K4A87_RS17440	COG0651	ATP synthesis coupled electron transport
K4A87_RS17450	COG2212	antiporter activity
K4A87_RS17455	COG1320	monovalent cation:proton antiporter activity
K4A87_RS17490	COG3023	N-Acetylmuramoyl-L-alanine amidase
K4A87_RS17500	COG4948	Mandelate Racemase Muconate Lactonizing
K4A87_RS17510	COG0531	amino acid
K4A87_RS17530	COG2133	pyrroloquinoline quinone binding
K4A87_RS17545	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K4A87_RS17550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K4A87_RS17565	COG1295	ribonuclease BN
K4A87_RS17570	COG0358	DNA primase activity
K4A87_RS17575	COG0109	protoheme IX farnesyltransferase activity
K4A87_RS17605	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K4A87_RS17615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K4A87_RS17635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K4A87_RS17640	COG0739	heme binding
K4A87_RS17645	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K4A87_RS17655	COG2223	nitrite transmembrane transporter activity
K4A87_RS17665	COG0708	Exodeoxyribonuclease III
K4A87_RS17680	COG1192	Involved in chromosome partitioning
K4A87_RS17685	COG1475	DNA binding
K4A87_RS17700	COG0463	Glycosyl transferase, family 2
K4A87_RS17715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K4A87_RS17725	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K4A87_RS17730	COG2003	Belongs to the UPF0758 family
K4A87_RS17735	COG0018	arginyl-trna synthetase
K4A87_RS17750	COG4221	oxidoreductase activity
K4A87_RS17755	COG1819	glycosyl
K4A87_RS17760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4A87_RS17770	COG1166	arginine decarboxylase activity
K4A87_RS17775	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K4A87_RS17800	COG3291	Pkd domain containing protein
K4A87_RS17800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K4A87_RS17815	COG0606	chelatase, subunit chli
K4A87_RS17830	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K4A87_RS17895	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_RS17915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K4A87_RS17920	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K4A87_RS17920	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K4A87_RS17955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K4A87_RS17975	COG1199	ATP-dependent helicase activity
K4A87_RS18050	COG2816	NAD+ diphosphatase activity
K4A87_RS18140	COG1136	(ABC) transporter
K4A87_RS18140	COG0577	efflux transmembrane transporter activity
K4A87_RS18170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4A87_RS18195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4A87_RS18250	COG3039	Transposase
K4A87_RS18285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K4A87_RS18330	COG1272	protein, Hemolysin III
K4A87_RS18335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4A87_RS18350	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K4A87_RS18355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K4A87_RS18375	COG2239	Acts as a magnesium transporter
K4A87_RS18380	COG3338	carbonate dehydratase activity
K4A87_RS18390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K4A87_RS18395	COG3387	PFAM Glycoside hydrolase 15-related
K4A87_RS18410	COG3100	YcgL domain-containing protein
K4A87_RS18415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K4A87_RS18425	COG0463	Glycosyl transferase, family 2
K4A87_RS18440	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_RS18465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K4A87_RS18480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K4A87_RS18535	COG1131	(ABC) transporter
K4A87_RS18615	COG0210	DNA helicase
K4A87_RS18625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4A87_RS18660	COG2091	lysine biosynthetic process via aminoadipic acid
K4A87_RS18675	COG0708	Exodeoxyribonuclease III
K4A87_RS18685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K4A87_RS18690	COG3162	membrane
K4A87_RS18725	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_RS18730	COG0179	Fumarylacetoacetate (FAA) hydrolase
K4A87_RS18735	COG4948	Mandelate Racemase Muconate Lactonizing
K4A87_RS18740	COG3254	rhamnose metabolic process
K4A87_RS18745	COG0738	Major facilitator superfamily
K4A87_RS18750	COG1414	Transcriptional regulator
K4A87_RS18755	COG1971	Probably functions as a manganese efflux pump
K4A87_RS18800	COG0784	Response regulator, receiver
K4A87_RS18800	COG2205	protein histidine kinase activity
K4A87_RS18820	COG3459	Glycosyltransferase 36 associated
K4A87_RS18825	COG2211	Major facilitator Superfamily
K4A87_RS18830	COG3265	gluconokinase activity
K4A87_RS18835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K4A87_RS18880	COG2911	Protein conserved in bacteria
K4A87_RS18885	COG0729	surface antigen
K4A87_RS18890	COG4771	TonB-dependent receptor
K4A87_RS18925	COG0009	L-threonylcarbamoyladenylate synthase
K4A87_RS18930	COG1754	DNA topoisomerase type I activity
K4A87_RS18930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K4A87_RS18940	COG0758	DNA mediated transformation
K4A87_RS18945	COG1652	LysM domain
K4A87_RS18950	COG0242	peptide deformylase activity
K4A87_RS18955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K4A87_RS18960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K4A87_RS18960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K4A87_RS18965	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K4A87_RS18995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K4A87_RS19010	COG1490	D-aminoacyl-tRNA deacylase activity
K4A87_RS19015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K4A87_RS19060	COG4555	ABC transporter
K4A87_RS19075	COG0543	2 iron, 2 sulfur cluster binding
K4A87_RS19075	COG0633	Ferredoxin
K4A87_RS19080	COG1131	(ABC) transporter
K4A87_RS19085	COG0842	Transport permease protein
K4A87_RS19095	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K4A87_RS19110	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K4A87_RS19150	COG3104	oligopeptide transport
K4A87_RS19155	COG3483	tryptophan 2,3-dioxygenase activity
K4A87_RS19160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K4A87_RS19175	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4A87_RS19200	COG0513	Belongs to the DEAD box helicase family
K4A87_RS19295	COG0676	glucose-6-phosphate 1-epimerase activity
K4A87_RS19310	COG0730	response to heat
K4A87_RS19335	COG0302	gtp cyclohydrolase
K4A87_RS19340	COG0477	Major facilitator Superfamily
K4A87_RS19380	COG3550	peptidyl-serine autophosphorylation
K4A87_RS19460	COG3549	Plasmid maintenance system killer
K4A87_RS19470	COG1074	ATP-dependent DNA helicase activity
K4A87_RS19475	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K4A87_RS19480	COG1127	ABC transporter
K4A87_RS19485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K4A87_RS19490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K4A87_RS19505	COG2853	Lipoprotein
K4A87_RS19520	COG1322	Protein conserved in bacteria
K4A87_RS19535	COG0531	amino acid
K4A87_RS19540	COG2203	Gaf domain
K4A87_RS19540	COG2199	diguanylate cyclase activity
K4A87_RS19570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K4A87_RS19575	COG0861	Integral membrane protein TerC family
K4A87_RS19590	COG0604	alcohol dehydrogenase
K4A87_RS19590	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_RS19590	COG3321	synthase
K4A87_RS19595	COG2937	Belongs to the GPAT DAPAT family
K4A87_RS19630	COG0284	orotidine-5'-phosphate decarboxylase activity
K4A87_RS19640	COG3132	Protein of unknown function, DUF480
K4A87_RS19650	COG0210	DNA helicase
K4A87_RS19655	COG1435	thymidine kinase activity
K4A87_RS19660	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K4A87_RS19695	COG0706	membrane insertase activity
K4A87_RS19700	COG0594	ribonuclease P activity