locus-tag	class	description
AC028_RS00005	COG2201	protein-glutamate methylesterase activity
AC028_RS00010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AC028_RS00015	COG2201	protein-glutamate methylesterase activity
AC028_RS00020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC028_RS00025	COG3590	peptidase
AC028_RS00035	COG0588	phosphoglycerate mutase activity
AC028_RS00040	COG1515	deoxyribonuclease V activity
AC028_RS00050	COG1741	Belongs to the pirin family
AC028_RS00065	COG1741	Belongs to the pirin family
AC028_RS00070	COG1966	Carbon starvation protein
AC028_RS00075	COG2879	small protein
AC028_RS00130	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AC028_RS00135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC028_RS00140	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC028_RS00145	COG2080	2 iron, 2 sulfur cluster binding
AC028_RS00150	COG0604	alcohol dehydrogenase
AC028_RS00150	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS00150	COG3321	synthase
AC028_RS00155	COG2203	Gaf domain
AC028_RS00155	COG3706	GGDEF domain
AC028_RS00155	COG4251	negative regulation of phosphorylation
AC028_RS00155	COG5001	Diguanylate cyclase
AC028_RS00160	COG0629	single-stranded DNA binding
AC028_RS00165	COG0142	geranyltranstransferase activity
AC028_RS00180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AC028_RS00195	COG0527	aspartate kinase activity
AC028_RS00200	COG0384	phenazine biosynthesis protein PhzF
AC028_RS00205	COG0384	phenazine biosynthesis protein PhzF
AC028_RS00215	COG1764	response to oxidative stress
AC028_RS00220	COG0540	Belongs to the ATCase OTCase family
AC028_RS00225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AC028_RS00230	COG1678	Uncharacterized ACR, COG1678
AC028_RS00240	COG0519	Catalyzes the synthesis of GMP from XMP
AC028_RS00265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AC028_RS00280	COG0739	heme binding
AC028_RS00300	COG0693	protein deglycase activity
AC028_RS00310	COG1959	2 iron, 2 sulfur cluster binding
AC028_RS00315	COG0719	Fe-S assembly protein
AC028_RS00320	COG0396	ATPase activity
AC028_RS00325	COG0719	Fe-S assembly protein
AC028_RS00330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC028_RS00340	COG2146	nitrite reductase [NAD(P)H] activity
AC028_RS00345	COG4774	siderophore transport
AC028_RS00350	COG3128	pkhd-type hydroxylase
AC028_RS00375	COG1477	protein flavinylation
AC028_RS00380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC028_RS00390	COG1555	photosystem II stabilization
AC028_RS00405	COG3178	'Phosphotransferase
AC028_RS00410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AC028_RS00425	COG0628	permease
AC028_RS00435	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AC028_RS00445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AC028_RS00465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AC028_RS00470	COG0271	Belongs to the BolA IbaG family
AC028_RS00480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AC028_RS00490	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AC028_RS00495	COG1137	ATPase activity
AC028_RS00510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC028_RS00515	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AC028_RS00520	COG1660	Displays ATPase and GTPase activities
AC028_RS00530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC028_RS00535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC028_RS00545	COG2239	Acts as a magnesium transporter
AC028_RS00555	COG1294	oxidase, subunit
AC028_RS00560	COG1271	oxidase subunit
AC028_RS00570	COG1113	amino acid transport
AC028_RS00600	COG2197	response regulator
AC028_RS00605	COG0531	amino acid
AC028_RS00725	COG2814	Major facilitator Superfamily
AC028_RS00740	COG0754	glutathionylspermidine amidase activity
AC028_RS00765	COG1842	Phage shock protein A
AC028_RS00775	COG0259	pyridoxamine-phosphate oxidase activity
AC028_RS00780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AC028_RS00785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AC028_RS00795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AC028_RS00800	COG2814	Major facilitator Superfamily
AC028_RS00820	COG3292	Two component regulator propeller
AC028_RS00820	COG0745	RESPONSE REGULATOR receiver
AC028_RS00820	COG2205	protein histidine kinase activity
AC028_RS00835	COG0784	Response regulator, receiver
AC028_RS00835	COG2198	Histidine kinase
AC028_RS00835	COG2205	protein histidine kinase activity
AC028_RS00840	COG2353	YceI-like domain
AC028_RS00860	COG1760	l-serine dehydratase
AC028_RS00875	COG0460	homoserine dehydrogenase
AC028_RS00875	COG0527	aspartate kinase activity
AC028_RS00880	COG0626	cystathionine gamma-synthase activity
AC028_RS00885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC028_RS00890	COG0739	heme binding
AC028_RS00895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AC028_RS00900	COG1272	protein, Hemolysin III
AC028_RS00905	COG2982	Protein involved in outer membrane biogenesis
AC028_RS00910	COG0516	GMP reductase activity
AC028_RS00910	COG0517	IMP dehydrogenase activity
AC028_RS00915	COG0463	Glycosyl transferase, family 2
AC028_RS00920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC028_RS00925	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AC028_RS00935	COG4771	TonB-dependent receptor
AC028_RS00940	COG1309	transcriptional regulator
AC028_RS00950	COG1960	acyl-CoA dehydrogenase activity
AC028_RS00975	COG0509	glycine decarboxylation via glycine cleavage system
AC028_RS00980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC028_RS00995	COG1742	UPF0060 membrane protein
AC028_RS01000	COG3956	TIGRFAM MazG family protein
AC028_RS01005	COG1218	3'(2'),5'-bisphosphate nucleotidase
AC028_RS01010	COG0494	nUDIX hydrolase
AC028_RS01020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AC028_RS01025	COG0837	glucose binding
AC028_RS01040	COG3858	chitin binding
AC028_RS01040	COG1388	LysM domain
AC028_RS01055	COG1472	Belongs to the glycosyl hydrolase 3 family
AC028_RS01075	COG1486	melibiose metabolic process
AC028_RS01085	COG3537	Alpha-1,2-mannosidase
AC028_RS01130	COG3142	Participates in the control of copper homeostasis
AC028_RS01135	COG1446	asparaginase
AC028_RS01165	COG0643	Histidine kinase
AC028_RS01165	COG0784	Response regulator, receiver
AC028_RS01165	COG2198	Histidine kinase
AC028_RS01170	COG0840	transmembrane signaling receptor activity
AC028_RS01175	COG0835	chemotaxis
AC028_RS01190	COG0189	ligase activity
AC028_RS01200	COG1397	ADP-ribosylglycohydrolase
AC028_RS01210	COG1199	ATP-dependent helicase activity
AC028_RS01220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC028_RS01225	COG1216	Glycosyl transferase, family 2
AC028_RS01225	COG1442	glycosyl transferase family 8
AC028_RS01245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC028_RS01255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AC028_RS01260	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AC028_RS01265	COG0535	radical SAM domain protein
AC028_RS01270	COG0535	radical SAM domain protein
AC028_RS01285	COG0837	glucose binding
AC028_RS01300	COG1643	Atp-dependent helicase
AC028_RS01305	COG0783	Belongs to the Dps family
AC028_RS01310	COG0514	ATP-dependent DNA helicase (RecQ)
AC028_RS01350	COG0840	transmembrane signaling receptor activity
AC028_RS01370	COG3920	Histidine kinase
AC028_RS01375	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AC028_RS01385	COG0602	queuosine metabolic process
AC028_RS01395	COG2885	chlorophyll binding
AC028_RS01400	COG0823	Involved in the tonB-independent uptake of proteins
AC028_RS01410	COG0848	biopolymer transport protein
AC028_RS01420	COG0824	Thioesterase
AC028_RS01425	COG2255	four-way junction helicase activity
AC028_RS01435	COG3158	transport of potassium into the cell
AC028_RS01440	COG0632	four-way junction helicase activity
AC028_RS01445	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AC028_RS01450	COG0217	transcriptional regulatory protein
AC028_RS01465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AC028_RS01480	COG0477	Major facilitator Superfamily
AC028_RS01530	COG0488	(ABC) transporter
AC028_RS01570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC028_RS01570	COG4651	solute:proton antiporter activity
AC028_RS01580	COG4772	TonB-dependent receptor
AC028_RS01590	COG4264	IucA IucC family
AC028_RS01605	COG0019	diaminopimelate decarboxylase activity
AC028_RS01640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AC028_RS01650	COG1492	cobalamin metabolic process
AC028_RS01660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC028_RS01685	COG4206	TonB-dependent receptor
AC028_RS01690	COG0542	response to heat
AC028_RS01695	COG1116	anion transmembrane transporter activity
AC028_RS01700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC028_RS01705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC028_RS01710	COG0667	Aldo Keto reductase
AC028_RS01715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC028_RS01725	COG4771	TonB-dependent receptor
AC028_RS01730	COG2827	Endonuclease containing a URI domain
AC028_RS01770	COG1877	trehalose-phosphatase activity
AC028_RS01775	COG3387	PFAM Glycoside hydrolase 15-related
AC028_RS01795	COG0840	transmembrane signaling receptor activity
AC028_RS01800	COG3011	Protein conserved in bacteria
AC028_RS01815	COG0564	pseudouridine synthase activity
AC028_RS01820	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC028_RS01830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC028_RS01830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AC028_RS01845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AC028_RS01850	COG0045	succinate-CoA ligase (ADP-forming) activity
AC028_RS01875	COG4969	Belongs to the N-Me-Phe pilin family
AC028_RS01890	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AC028_RS01895	COG0237	dephospho-CoA kinase activity
AC028_RS01900	COG3039	Transposase
AC028_RS01925	COG0745	RESPONSE REGULATOR receiver
AC028_RS01935	COG0189	ligase activity
AC028_RS02005	COG2022	thiamine diphosphate biosynthetic process
AC028_RS02010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AC028_RS02015	COG3273	potassium ion transport
AC028_RS02015	COG0471	metal ion transport
AC028_RS02040	COG1970	mechanosensitive ion channel activity
AC028_RS02050	COG1609	Transcriptional regulator
AC028_RS02060	COG3250	beta-galactosidase activity
AC028_RS02065	COG4948	Mandelate Racemase Muconate Lactonizing
AC028_RS02080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC028_RS02090	COG0308	aminopeptidase N
AC028_RS02140	COG3039	Transposase
AC028_RS02160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC028_RS02170	COG2895	sulfate adenylyltransferase (ATP) activity
AC028_RS02170	COG0529	Catalyzes the synthesis of activated sulfate
AC028_RS02175	COG0175	sulfate reduction
AC028_RS02180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC028_RS02185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC028_RS02190	COG0175	sulfate reduction
AC028_RS02210	COG2205	protein histidine kinase activity
AC028_RS02210	COG2198	Histidine kinase
AC028_RS02210	COG0784	Response regulator, receiver
AC028_RS02250	COG3588	fructose-bisphosphate aldolase
AC028_RS02260	COG0469	pyruvate kinase activity
AC028_RS02270	COG0126	phosphoglycerate kinase activity
AC028_RS02290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AC028_RS02300	COG3047	cAMP biosynthetic process
AC028_RS02315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC028_RS02315	COG3453	Protein conserved in bacteria
AC028_RS02320	COG0725	ABC transporter, periplasmic molybdate-binding protein
AC028_RS02325	COG4149	molybdate abc transporter
AC028_RS02330	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AC028_RS02365	COG1376	ErfK ybiS ycfS ynhG family protein
AC028_RS02370	COG0739	heme binding
AC028_RS02375	COG4773	Receptor
AC028_RS02405	COG3039	Transposase
AC028_RS02415	COG3039	Transposase
AC028_RS02420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AC028_RS02425	COG1301	dicarboxylic acid transport
AC028_RS02435	COG2304	oxidoreductase activity
AC028_RS02455	COG0714	Associated with various cellular activities
AC028_RS02485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AC028_RS02495	COG0372	Belongs to the citrate synthase family
AC028_RS02510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AC028_RS02520	COG2721	sulfolactate sulfo-lyase activity
AC028_RS02535	COG2271	Major facilitator Superfamily
AC028_RS02550	COG0583	DNA-binding transcription factor activity
AC028_RS02555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC028_RS02570	COG1561	YicC-like family, N-terminal region
AC028_RS02575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AC028_RS02585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AC028_RS02590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AC028_RS02605	COG0006	proline dipeptidase activity
AC028_RS02610	COG0006	proline dipeptidase activity
AC028_RS02615	COG3079	Belongs to the UPF0149 family
AC028_RS02635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AC028_RS02645	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AC028_RS02655	COG2912	Transglutaminase-like superfamily
AC028_RS02660	COG1773	rubredoxin
AC028_RS02665	COG0352	thiamine-phosphate diphosphorylase activity
AC028_RS02685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC028_RS02705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC028_RS02735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC028_RS02740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC028_RS02745	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS02755	COG0671	phosphoesterase, PA-phosphatase related
AC028_RS02765	COG3781	membrane
AC028_RS02775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC028_RS02780	COG0563	adenylate kinase activity
AC028_RS02795	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AC028_RS02805	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AC028_RS02825	COG3710	Transcriptional regulator
AC028_RS02830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AC028_RS02845	COG0840	transmembrane signaling receptor activity
AC028_RS02855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AC028_RS02875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC028_RS02880	COG0473	3-isopropylmalate dehydrogenase activity
AC028_RS02885	COG0066	3-isopropylmalate dehydratase activity
AC028_RS02890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AC028_RS02910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC028_RS02915	COG1538	Outer membrane efflux protein
AC028_RS02920	COG1519	Transferase
AC028_RS02930	COG1560	Kdo2-lipid A biosynthetic process
AC028_RS02970	COG3039	Transposase
AC028_RS02975	COG0436	Aminotransferase
AC028_RS02990	COG0726	polysaccharide deacetylase
AC028_RS02995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC028_RS03010	COG3964	amidohydrolase
AC028_RS03015	COG0402	S-adenosylhomocysteine deaminase activity
AC028_RS03040	COG1307	EDD domain protein, DegV family
AC028_RS03045	COG0242	peptide deformylase activity
AC028_RS03070	COG0457	Tetratricopeptide repeat
AC028_RS03075	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AC028_RS03080	COG1215	transferase activity, transferring glycosyl groups
AC028_RS03085	COG1215	transferase activity, transferring glycosyl groups
AC028_RS03100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AC028_RS03155	COG2188	Transcriptional regulator
AC028_RS03165	COG1450	Type ii and iii secretion system protein
AC028_RS03180	COG3166	PFAM Fimbrial assembly family protein
AC028_RS03185	COG3156	type II secretion system protein K
AC028_RS03190	COG4795	General secretion pathway protein
AC028_RS03195	COG2165	general secretion pathway protein
AC028_RS03200	COG4970	Tfp pilus assembly protein FimT
AC028_RS03205	COG2165	general secretion pathway protein
AC028_RS03210	COG1459	type II secretion system
AC028_RS03220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC028_RS03225	COG1404	Belongs to the peptidase S8 family
AC028_RS03235	COG5295	Hep Hag repeat protein
AC028_RS03245	COG3039	Transposase
AC028_RS03255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AC028_RS03255	COG0047	phosphoribosylformylglycinamidine synthase activity
AC028_RS03270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC028_RS03285	COG4974	Belongs to the 'phage' integrase family
AC028_RS03300	COG0795	lipopolysaccharide-transporting ATPase activity
AC028_RS03310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC028_RS03325	COG0525	valine-tRNA ligase activity
AC028_RS03340	COG0741	lytic transglycosylase activity
AC028_RS03360	COG1183	phosphatidylcholine synthase activity
AC028_RS03370	COG0442	prolyl-tRNA aminoacylation
AC028_RS03430	COG5489	Protein of unknown function (DUF736)
AC028_RS03500	COG2814	Major facilitator Superfamily
AC028_RS03515	COG0583	DNA-binding transcription factor activity
AC028_RS03530	COG1902	pentaerythritol trinitrate reductase activity
AC028_RS03530	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC028_RS03535	COG0583	DNA-binding transcription factor activity
AC028_RS03555	COG4962	Type ii secretion system protein e
AC028_RS03560	COG3838	Conjugal transfer protein Trbc
AC028_RS03570	COG3451	type IV secretory pathway VirB4
AC028_RS03610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC028_RS03610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC028_RS03620	COG2878	Part of a membrane complex involved in electron transport
AC028_RS03640	COG1595	DNA-templated transcription, initiation
AC028_RS03665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC028_RS03680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC028_RS03685	COG0251	oxidation-reduction process
AC028_RS03695	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AC028_RS03695	COG0392	lysyltransferase activity
AC028_RS03730	COG2814	Major facilitator Superfamily
AC028_RS03735	COG1902	pentaerythritol trinitrate reductase activity
AC028_RS03745	COG2824	Alkylphosphonate utilization operon protein PhnA
AC028_RS03755	COG1047	Peptidyl-prolyl cis-trans
AC028_RS03760	COG1077	Cell shape determining protein MreB Mrl
AC028_RS03780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AC028_RS03790	COG5487	UPF0391 membrane protein
AC028_RS03795	COG1451	nucleotide metabolic process
AC028_RS03820	COG0183	Belongs to the thiolase family
AC028_RS03855	COG1793	dna ligase
AC028_RS03855	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AC028_RS03865	COG1793	dna ligase
AC028_RS03870	COG1201	RNA secondary structure unwinding
AC028_RS03880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC028_RS03885	COG1278	Cold shock
AC028_RS03890	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AC028_RS03895	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AC028_RS03900	COG1472	Belongs to the glycosyl hydrolase 3 family
AC028_RS03905	COG3046	protein related to deoxyribodipyrimidine photolyase
AC028_RS03910	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AC028_RS03915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AC028_RS03920	COG2954	triphosphatase activity
AC028_RS03925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC028_RS03935	COG1381	Involved in DNA repair and RecF pathway recombination
AC028_RS03940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AC028_RS03945	COG0571	ribonuclease III activity
AC028_RS03960	COG0481	GTPase activity
AC028_RS03965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC028_RS03980	COG1024	Enoyl-CoA hydratase
AC028_RS03980	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC028_RS04000	COG1166	arginine decarboxylase activity
AC028_RS04005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AC028_RS04045	COG0606	chelatase, subunit chli
AC028_RS04060	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AC028_RS04105	COG1690	Belongs to the RtcB family
AC028_RS04150	COG0642	Histidine kinase
AC028_RS04175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC028_RS04200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AC028_RS04205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC028_RS04220	COG0753	catalase activity
AC028_RS04235	COG2197	response regulator
AC028_RS04240	COG4585	Histidine kinase
AC028_RS04245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_RS04250	COG1136	(ABC) transporter
AC028_RS04275	COG0697	spore germination
AC028_RS04295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC028_RS04300	COG0180	Tryptophanyl-tRNA synthetase
AC028_RS04305	COG3237	CsbD-like
AC028_RS04345	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC028_RS04365	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AC028_RS04370	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AC028_RS04370	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AC028_RS04415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AC028_RS04445	COG1199	ATP-dependent helicase activity
AC028_RS04460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC028_RS04530	COG0625	glutathione transferase activity
AC028_RS04565	COG4555	ABC transporter
AC028_RS04575	COG1476	TRANSCRIPTIONal
AC028_RS04595	COG1230	cation diffusion facilitator family transporter
AC028_RS04600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC028_RS04605	COG1131	(ABC) transporter
AC028_RS04610	COG0842	Transport permease protein
AC028_RS04615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AC028_RS04645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC028_RS04655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC028_RS04670	COG0045	succinate-CoA ligase (ADP-forming) activity
AC028_RS04670	COG1042	CoA-binding domain protein
AC028_RS04670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AC028_RS04675	COG2239	Acts as a magnesium transporter
AC028_RS04695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC028_RS04700	COG3387	PFAM Glycoside hydrolase 15-related
AC028_RS04715	COG3100	YcgL domain-containing protein
AC028_RS04720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AC028_RS04730	COG0463	Glycosyl transferase, family 2
AC028_RS04740	COG3039	Transposase
AC028_RS04745	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS04785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC028_RS04800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC028_RS04830	COG4946	Tricorn protease homolog
AC028_RS04830	COG0823	Involved in the tonB-independent uptake of proteins
AC028_RS04830	COG1506	peptidase
AC028_RS04850	COG0408	coproporphyrinogen oxidase activity
AC028_RS04890	COG0515	serine threonine protein kinase
AC028_RS04890	COG2815	serine threonine protein kinase
AC028_RS04895	COG0631	protein serine/threonine phosphatase activity
AC028_RS04920	COG0667	Aldo Keto reductase
AC028_RS04925	COG0583	DNA-binding transcription factor activity
AC028_RS04965	COG1595	DNA-templated transcription, initiation
AC028_RS05070	COG3039	Transposase
AC028_RS05090	COG0366	Alpha amylase catalytic
AC028_RS05095	COG0366	Alpha amylase catalytic
AC028_RS05100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC028_RS05120	COG0657	acetylesterase activity
AC028_RS05120	COG2755	lipolytic protein G-D-S-L family
AC028_RS05130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC028_RS05145	COG3507	Belongs to the glycosyl hydrolase 43 family
AC028_RS05150	COG1609	Transcriptional regulator
AC028_RS05165	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AC028_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS05180	COG2755	lipolytic protein G-D-S-L family
AC028_RS05190	COG3186	Phenylalanine-4-hydroxylase
AC028_RS05195	COG1522	sequence-specific DNA binding
AC028_RS05205	COG1752	Esterase of the alpha-beta hydrolase superfamily
AC028_RS05215	COG1119	ATPase activity
AC028_RS05230	COG1125	glycine betaine transport
AC028_RS05230	COG0517	IMP dehydrogenase activity
AC028_RS05245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC028_RS05280	COG0489	protein tyrosine kinase activity
AC028_RS05285	COG2062	phosphohistidine phosphatase, SixA
AC028_RS05295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC028_RS05340	COG1968	undecaprenyl-diphosphatase activity
AC028_RS05350	COG0174	glutamine synthetase
AC028_RS05355	COG0347	Belongs to the P(II) protein family
AC028_RS05360	COG0004	ammonium transporteR
AC028_RS05365	COG3852	Histidine kinase
AC028_RS05370	COG2204	response regulator
AC028_RS05375	COG2032	superoxide dismutase activity
AC028_RS05380	COG2032	superoxide dismutase activity
AC028_RS05390	COG0346	lactoylglutathione lyase activity
AC028_RS05400	COG0183	Belongs to the thiolase family
AC028_RS05435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC028_RS05440	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AC028_RS05445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AC028_RS05460	COG0028	Belongs to the TPP enzyme family
AC028_RS05470	COG0028	Belongs to the TPP enzyme family
AC028_RS05475	COG2205	protein histidine kinase activity
AC028_RS05500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AC028_RS05515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC028_RS05525	COG0596	Alpha beta hydrolase
AC028_RS05530	COG0727	PFAM Uncharacterised protein family (UPF0153)
AC028_RS05535	COG0318	PFAM AMP-dependent synthetase and ligase
AC028_RS05550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC028_RS05565	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC028_RS05580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC028_RS05595	COG0564	pseudouridine synthase activity
AC028_RS05615	COG1446	asparaginase
AC028_RS05620	COG0339	signal peptide processing
AC028_RS05660	COG0475	glutathione-regulated potassium exporter activity
AC028_RS05665	COG0583	DNA-binding transcription factor activity
AC028_RS05670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AC028_RS05675	COG2224	Isocitrate lyase
AC028_RS05715	COG4770	biotin carboxylase activity
AC028_RS05720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC028_RS05725	COG1960	acyl-CoA dehydrogenase activity
AC028_RS05790	COG0697	spore germination
AC028_RS05800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AC028_RS05805	COG1846	Transcriptional regulator
AC028_RS05810	COG1764	response to oxidative stress
AC028_RS05840	COG2130	NADP-dependent
AC028_RS05855	COG1187	pseudouridine synthase activity
AC028_RS05870	COG1643	Atp-dependent helicase
AC028_RS05875	COG4807	Protein conserved in bacteria
AC028_RS05880	COG2351	hydroxyisourate hydrolase activity
AC028_RS05885	COG2072	flavoprotein involved in K transport
AC028_RS05905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AC028_RS05915	COG0583	DNA-binding transcription factor activity
AC028_RS05950	COG2252	PERMEase
AC028_RS05975	COG0084	hydrolase, TatD family'
AC028_RS05985	COG0583	DNA-binding transcription factor activity
AC028_RS05990	COG2814	Major facilitator Superfamily
AC028_RS06000	COG2267	carboxylic ester hydrolase activity
AC028_RS06005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AC028_RS06010	COG1902	pentaerythritol trinitrate reductase activity
AC028_RS06030	COG0745	RESPONSE REGULATOR receiver
AC028_RS06035	COG2205	protein histidine kinase activity
AC028_RS06040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_RS06060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC028_RS06065	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AC028_RS06070	COG0583	DNA-binding transcription factor activity
AC028_RS06105	COG0702	epimerase
AC028_RS06110	COG1733	regulation of RNA biosynthetic process
AC028_RS06140	COG0129	dihydroxy-acid dehydratase activity
AC028_RS06155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AC028_RS06210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AC028_RS06215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AC028_RS06240	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AC028_RS06245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AC028_RS06255	COG3485	protocatechuate 3,4-dioxygenase
AC028_RS06260	COG3485	protocatechuate 3,4-dioxygenase
AC028_RS06270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC028_RS06275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AC028_RS06285	COG1414	Transcriptional regulator
AC028_RS06295	COG0657	acetylesterase activity
AC028_RS06310	COG0445	tRNA wobble uridine modification
AC028_RS06320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AC028_RS06345	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS06350	COG2267	carboxylic ester hydrolase activity
AC028_RS06360	COG0156	8-amino-7-oxononanoate synthase activity
AC028_RS06365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AC028_RS06370	COG1040	competence protein
AC028_RS06375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AC028_RS06385	COG0582	viral genome integration into host DNA
AC028_RS06430	COG3321	synthase
AC028_RS06430	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS06430	COG0604	alcohol dehydrogenase
AC028_RS06435	COG2937	Belongs to the GPAT DAPAT family
AC028_RS06470	COG0284	orotidine-5'-phosphate decarboxylase activity
AC028_RS06475	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AC028_RS06485	COG3132	Protein of unknown function, DUF480
AC028_RS06500	COG0210	DNA helicase
AC028_RS06505	COG1435	thymidine kinase activity
AC028_RS06515	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AC028_RS06525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC028_RS06555	COG3135	benzoate transporter
AC028_RS06575	COG0676	glucose-6-phosphate 1-epimerase activity
AC028_RS06585	COG3012	SEC-C Motif Domain Protein
AC028_RS06590	COG0730	response to heat
AC028_RS06610	COG0302	gtp cyclohydrolase
AC028_RS06625	COG1566	PFAM secretion protein HlyD family protein
AC028_RS06635	COG1289	transmembrane transporter activity
AC028_RS06640	COG0477	Major facilitator Superfamily
AC028_RS06650	COG0583	DNA-binding transcription factor activity
AC028_RS06655	COG4221	oxidoreductase activity
AC028_RS06665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC028_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS06795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AC028_RS06800	COG1074	ATP-dependent DNA helicase activity
AC028_RS06805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AC028_RS06840	COG1127	ABC transporter
AC028_RS06845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC028_RS06850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC028_RS06865	COG2853	Lipoprotein
AC028_RS06875	COG0386	Belongs to the glutathione peroxidase family
AC028_RS06885	COG1322	Protein conserved in bacteria
AC028_RS06895	COG0625	glutathione transferase activity
AC028_RS06905	COG0531	amino acid
AC028_RS06925	COG3835	regulator
AC028_RS06930	COG1929	Belongs to the glycerate kinase type-1 family
AC028_RS06935	COG2271	Major facilitator Superfamily
AC028_RS06950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC028_RS06960	COG0861	Integral membrane protein TerC family
AC028_RS06970	COG0584	glycerophosphoryl diester phosphodiesterase
AC028_RS06985	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AC028_RS06995	COG0706	membrane insertase activity
AC028_RS07000	COG0594	ribonuclease P activity
AC028_RS07015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AC028_RS07025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AC028_RS07030	COG0187	DNA topoisomerase II activity
AC028_RS07040	COG0501	Belongs to the peptidase M48B family
AC028_RS07075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AC028_RS07085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC028_RS07120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC028_RS07125	COG0793	Belongs to the peptidase S41A family
AC028_RS07130	COG4942	peptidase
AC028_RS07140	COG2234	aminopeptidase activity
AC028_RS07150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC028_RS07155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC028_RS07170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC028_RS07180	COG1064	alcohol dehydrogenase
AC028_RS07220	COG0778	Nitroreductase
AC028_RS07225	COG2353	YceI-like domain
AC028_RS07255	COG3052	prosthetic group binding
AC028_RS07280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AC028_RS07290	COG1802	Transcriptional regulator
AC028_RS07355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC028_RS07360	COG0752	glycyl-tRNA synthetase alpha subunit
AC028_RS07375	COG3039	Transposase
AC028_RS07410	COG3039	Transposase
AC028_RS07425	COG0729	surface antigen
AC028_RS07430	COG2911	Protein conserved in bacteria
AC028_RS07450	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC028_RS07460	COG3265	gluconokinase activity
AC028_RS07465	COG2211	Major facilitator Superfamily
AC028_RS07470	COG3459	Glycosyltransferase 36 associated
AC028_RS07485	COG2205	protein histidine kinase activity
AC028_RS07490	COG1971	Probably functions as a manganese efflux pump
AC028_RS07495	COG1414	Transcriptional regulator
AC028_RS07500	COG0738	Major facilitator superfamily
AC028_RS07505	COG3254	rhamnose metabolic process
AC028_RS07510	COG4948	Mandelate Racemase Muconate Lactonizing
AC028_RS07515	COG0179	Fumarylacetoacetate (FAA) hydrolase
AC028_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS07540	COG3507	Belongs to the glycosyl hydrolase 43 family
AC028_RS07570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC028_RS07580	COG3162	membrane
AC028_RS07585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC028_RS07600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC028_RS07610	COG1940	carbohydrate kinase activity
AC028_RS07610	COG1846	Transcriptional regulator
AC028_RS07615	COG0708	Exodeoxyribonuclease III
AC028_RS07630	COG2091	lysine biosynthetic process via aminoadipic acid
AC028_RS07640	COG3540	Alkaline phosphatase
AC028_RS07645	COG0357	Ribosomal RNA small subunit methyltransferase G
AC028_RS07665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_RS07690	COG2159	amidohydrolase
AC028_RS07705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC028_RS07710	COG0583	DNA-binding transcription factor activity
AC028_RS07715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC028_RS07725	COG0210	DNA helicase
AC028_RS07800	COG3264	Mechanosensitive ion channel
AC028_RS07800	COG1511	domain protein
AC028_RS07805	COG1368	sulfuric ester hydrolase activity
AC028_RS07815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC028_RS07820	COG2354	Protein conserved in bacteria
AC028_RS07830	COG0297	glycogen (starch) synthase activity
AC028_RS07835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC028_RS07840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC028_RS07865	COG0702	epimerase
AC028_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS07905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC028_RS07910	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS07920	COG0513	Belongs to the DEAD box helicase family
AC028_RS07925	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC028_RS07940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AC028_RS07950	COG3483	tryptophan 2,3-dioxygenase activity
AC028_RS07975	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AC028_RS07995	COG1320	monovalent cation:proton antiporter activity
AC028_RS08000	COG2212	antiporter activity
AC028_RS08010	COG0651	ATP synthesis coupled electron transport
AC028_RS08015	COG1006	Multisubunit Na H antiporter MnhC subunit
AC028_RS08020	COG2111	Na H antiporter
AC028_RS08020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC028_RS08045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AC028_RS08050	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AC028_RS08065	COG0456	acetyltransferase
AC028_RS08070	COG1597	lipid kinase activity
AC028_RS08095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AC028_RS08100	COG0134	indole-3-glycerol-phosphate synthase activity
AC028_RS08110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC028_RS08115	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AC028_RS08125	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AC028_RS08135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AC028_RS08150	COG1051	belongs to the nudix hydrolase family
AC028_RS08190	COG0316	Belongs to the HesB IscA family
AC028_RS08210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC028_RS08230	COG2814	Major facilitator Superfamily
AC028_RS08240	COG2814	Major facilitator Superfamily
AC028_RS08245	COG1289	transmembrane transporter activity
AC028_RS08250	COG0151	Belongs to the GarS family
AC028_RS08260	COG0138	bifunctional purine biosynthesis protein purh
AC028_RS08265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC028_RS08270	COG2267	carboxylic ester hydrolase activity
AC028_RS08275	COG2453	phosphatase
AC028_RS08275	COG0671	phosphoesterase, PA-phosphatase related
AC028_RS08305	COG4589	Belongs to the CDS family
AC028_RS08310	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AC028_RS08335	COG2264	protein methyltransferase activity
AC028_RS08355	COG0439	Biotin carboxylase
AC028_RS08365	COG0511	ligase activity, forming carbon-carbon bonds
AC028_RS08370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AC028_RS08380	COG1324	tolerance protein
AC028_RS08390	COG2356	endonuclease I
AC028_RS08400	COG0459	protein refolding
AC028_RS08415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AC028_RS08435	COG3386	PFAM SMP-30 Gluconolaconase
AC028_RS08445	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AC028_RS08485	COG0493	'glutamate synthase
AC028_RS08490	COG0067	glutamate synthase
AC028_RS08490	COG0070	glutamate synthase
AC028_RS08490	COG0069	glutamate synthase activity
AC028_RS08580	COG1111	helicase
AC028_RS08580	COG1205	dead DEAH box helicase
AC028_RS08585	COG1272	protein, Hemolysin III
AC028_RS08605	COG0300	oxidoreductase activity
AC028_RS08610	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS08640	COG2249	NAD(P)H dehydrogenase (quinone) activity
AC028_RS08645	COG3039	Transposase
AC028_RS08705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AC028_RS08740	COG3237	CsbD-like
AC028_RS08790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC028_RS08800	COG0477	Major facilitator Superfamily
AC028_RS08855	COG0714	Associated with various cellular activities
AC028_RS08885	COG3039	Transposase
AC028_RS08905	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AC028_RS08910	COG3710	Transcriptional regulator
AC028_RS08930	COG2197	response regulator
AC028_RS08935	COG4585	Histidine kinase
AC028_RS08950	COG1304	FMN binding
AC028_RS08975	COG1012	belongs to the aldehyde dehydrogenase family
AC028_RS08990	COG4772	TonB-dependent receptor
AC028_RS09030	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AC028_RS09045	COG3039	Transposase
AC028_RS09100	COG0519	Catalyzes the synthesis of GMP from XMP
AC028_RS09100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC028_RS09110	COG0805	protein transport
AC028_RS09115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC028_RS09120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC028_RS09130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AC028_RS09150	COG2974	May be involved in recombination
AC028_RS09155	COG0037	tRNA processing
AC028_RS09165	COG2115	Belongs to the xylose isomerase family
AC028_RS09175	COG3661	Belongs to the glycosyl hydrolase 67 family
AC028_RS09185	COG4948	Mandelate Racemase Muconate Lactonizing
AC028_RS09195	COG1472	Belongs to the glycosyl hydrolase 3 family
AC028_RS09200	COG3039	Transposase
AC028_RS09210	COG0246	Mannitol dehydrogenase
AC028_RS09260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC028_RS09290	COG3386	PFAM SMP-30 Gluconolaconase
AC028_RS09300	COG3250	beta-galactosidase activity
AC028_RS09305	COG1904	glucuronate isomerase
AC028_RS09320	COG3693	PFAM glycoside hydrolase, family 10
AC028_RS09335	COG2211	Major facilitator Superfamily
AC028_RS09415	COG5297	Belongs to the glycosyl hydrolase family 6
AC028_RS09465	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC028_RS09570	COG4221	oxidoreductase activity
AC028_RS09585	COG4221	oxidoreductase activity
AC028_RS09595	COG0435	Glutathione S-transferase
AC028_RS09630	COG0823	Involved in the tonB-independent uptake of proteins
AC028_RS09630	COG1506	peptidase
AC028_RS09675	COG0697	spore germination
AC028_RS09695	COG1113	amino acid transport
AC028_RS09715	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AC028_RS09765	COG0840	transmembrane signaling receptor activity
AC028_RS09770	COG5297	Belongs to the glycosyl hydrolase family 6
AC028_RS09770	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC028_RS09775	COG0659	secondary active sulfate transmembrane transporter activity
AC028_RS09800	COG2943	transferase activity, transferring hexosyl groups
AC028_RS09810	COG3275	phosphorelay sensor kinase activity
AC028_RS09820	COG0181	hydroxymethylbilane synthase activity
AC028_RS09850	COG1505	serine-type exopeptidase activity
AC028_RS09855	COG0436	Aminotransferase
AC028_RS09870	COG2832	Protein of unknown function (DUF454)
AC028_RS09880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AC028_RS09890	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AC028_RS09895	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AC028_RS09900	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AC028_RS09925	COG2226	methyltransferase
AC028_RS09930	COG3300	MHYT domain
AC028_RS09930	COG5001	Diguanylate cyclase
AC028_RS09935	COG0308	aminopeptidase N
AC028_RS09985	COG3284	Transcriptional regulator
AC028_RS09990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC028_RS09995	COG1077	Cell shape determining protein MreB Mrl
AC028_RS10000	COG1792	Involved in formation and maintenance of cell shape
AC028_RS10015	COG0772	Belongs to the SEDS family
AC028_RS10025	COG2951	lytic endotransglycosylase activity
AC028_RS10030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AC028_RS10040	COG1686	Belongs to the peptidase S11 family
AC028_RS10050	COG2921	Belongs to the UPF0250 family
AC028_RS10055	COG0321	lipoyl(octanoyl) transferase activity
AC028_RS10060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AC028_RS10075	COG0583	DNA-binding transcription factor activity
AC028_RS10085	COG1051	belongs to the nudix hydrolase family
AC028_RS10085	COG1056	cytidyltransferase-related domain
AC028_RS10120	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AC028_RS10130	COG2823	Periplasmic or secreted lipoprotein
AC028_RS10135	COG4251	negative regulation of phosphorylation
AC028_RS10140	COG0784	Response regulator, receiver
AC028_RS10145	COG4191	Histidine kinase
AC028_RS10150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AC028_RS10205	COG1459	type II secretion system
AC028_RS10210	COG2165	general secretion pathway protein
AC028_RS10225	COG4795	General secretion pathway protein
AC028_RS10255	COG3250	beta-galactosidase activity
AC028_RS10270	COG2188	Transcriptional regulator
AC028_RS10280	COG1609	Transcriptional regulator
AC028_RS10285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AC028_RS10290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AC028_RS10305	COG0617	tRNA 3'-terminal CCA addition
AC028_RS10310	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AC028_RS10315	COG1012	belongs to the aldehyde dehydrogenase family
AC028_RS10320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC028_RS10335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC028_RS10350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AC028_RS10355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AC028_RS10375	COG2205	protein histidine kinase activity
AC028_RS10405	COG3791	Glutathione-dependent formaldehyde-activating
AC028_RS10420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC028_RS10430	COG0697	spore germination
AC028_RS10445	COG0488	(ABC) transporter
AC028_RS10455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC028_RS10460	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AC028_RS10470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC028_RS10470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC028_RS10490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AC028_RS10495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC028_RS10500	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AC028_RS10525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AC028_RS10530	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AC028_RS10535	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AC028_RS10540	COG2205	protein histidine kinase activity
AC028_RS10545	COG0745	RESPONSE REGULATOR receiver
AC028_RS10550	COG0277	FAD linked oxidase domain protein
AC028_RS10555	COG1988	membrane-bound metal-dependent
AC028_RS10560	COG0792	nuclease activity
AC028_RS10595	COG0275	rRNA processing
AC028_RS10600	COG3116	cell division
AC028_RS10615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AC028_RS10620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC028_RS10625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC028_RS10635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AC028_RS10640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC028_RS10645	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC028_RS10650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AC028_RS10665	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AC028_RS10675	COG0739	heme binding
AC028_RS10680	COG0653	protein targeting
AC028_RS10685	COG0494	nUDIX hydrolase
AC028_RS10695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC028_RS10710	COG3321	synthase
AC028_RS10710	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS10710	COG0604	alcohol dehydrogenase
AC028_RS10735	COG0366	Alpha amylase catalytic
AC028_RS10770	COG2226	methyltransferase
AC028_RS10775	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AC028_RS10790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AC028_RS10830	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AC028_RS10840	COG4106	trans-aconitate 2-methyltransferase activity
AC028_RS10845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AC028_RS10860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC028_RS10865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AC028_RS10875	COG0667	Aldo Keto reductase
AC028_RS10885	COG4771	TonB-dependent receptor
AC028_RS10905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC028_RS10910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AC028_RS10920	COG2175	clavaminate synthase activity
AC028_RS10930	COG4181	ATPase activity
AC028_RS10945	COG0642	Histidine kinase
AC028_RS10955	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AC028_RS10975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AC028_RS10980	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AC028_RS10995	COG3829	transcription factor binding
AC028_RS11005	COG1116	anion transmembrane transporter activity
AC028_RS11010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC028_RS11020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC028_RS11025	COG0431	NADPH-dependent FMN reductase
AC028_RS11035	COG3039	Transposase
AC028_RS11050	COG0747	negative chemotaxis
AC028_RS11060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC028_RS11070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AC028_RS11075	COG2967	ApaG domain
AC028_RS11080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AC028_RS11085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AC028_RS11090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC028_RS11095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AC028_RS11100	COG0123	including yeast histone deacetylase and acetoin utilization protein
AC028_RS11105	COG2096	Adenosyltransferase
AC028_RS11120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC028_RS11125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC028_RS11155	COG3384	dioxygenase
AC028_RS11160	COG0583	DNA-binding transcription factor activity
AC028_RS11175	COG1012	belongs to the aldehyde dehydrogenase family
AC028_RS11180	COG1024	Enoyl-CoA hydratase
AC028_RS11210	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AC028_RS11235	COG0697	spore germination
AC028_RS11245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC028_RS11270	COG2197	response regulator
AC028_RS11280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC028_RS11290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AC028_RS11295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC028_RS11305	COG0583	DNA-binding transcription factor activity
AC028_RS11310	COG3634	alkyl hydroperoxide reductase activity
AC028_RS11320	COG2890	protein-(glutamine-N5) methyltransferase activity
AC028_RS11340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC028_RS11340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC028_RS11370	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC028_RS11415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC028_RS11420	COG1404	Belongs to the peptidase S8 family
AC028_RS11430	COG1404	Belongs to the peptidase S8 family
AC028_RS11435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AC028_RS11465	COG1295	ribonuclease BN
AC028_RS11470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC028_RS11475	COG1254	Belongs to the acylphosphatase family
AC028_RS11490	COG0521	Mo-molybdopterin cofactor biosynthetic process
AC028_RS11500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AC028_RS11505	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AC028_RS11515	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AC028_RS11520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AC028_RS11530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC028_RS11535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AC028_RS11540	COG0193	aminoacyl-tRNA hydrolase activity
AC028_RS11545	COG0012	GTP binding
AC028_RS11565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC028_RS11580	COG0250	Participates in transcription elongation, termination and antitermination
AC028_RS11585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AC028_RS11590	COG0081	regulation of translation
AC028_RS11595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AC028_RS11600	COG0222	ribosome binding
AC028_RS11605	COG0085	RNA polymerase activity
AC028_RS11610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AC028_RS11615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AC028_RS11620	COG0049	tRNA binding
AC028_RS11625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AC028_RS11630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC028_RS11635	COG0051	transcription antitermination factor activity, RNA binding
AC028_RS11640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AC028_RS11645	COG0088	Forms part of the polypeptide exit tunnel
AC028_RS11650	COG0089	rRNA binding
AC028_RS11655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AC028_RS11660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AC028_RS11670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AC028_RS11675	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AC028_RS11680	COG0255	Belongs to the universal ribosomal protein uL29 family
AC028_RS11685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AC028_RS11695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AC028_RS11700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AC028_RS11710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AC028_RS11715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AC028_RS11720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AC028_RS11730	COG1841	ribosomal large subunit assembly
AC028_RS11735	COG0200	Binds to the 23S rRNA
AC028_RS11740	COG0201	protein transport
AC028_RS11765	COG0203	ribosomal protein L17
AC028_RS11770	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AC028_RS11790	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AC028_RS11805	COG0154	amidase activity
AC028_RS11815	COG1217	gtp-binding protein TYPA
AC028_RS11820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC028_RS11825	COG0039	L-malate dehydrogenase activity
AC028_RS11830	COG0625	glutathione transferase activity
AC028_RS11845	COG1902	pentaerythritol trinitrate reductase activity
AC028_RS11845	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC028_RS11850	COG0604	alcohol dehydrogenase
AC028_RS11880	COG0156	8-amino-7-oxononanoate synthase activity
AC028_RS11885	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AC028_RS11890	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AC028_RS11895	COG4208	sulfate ABC transporter
AC028_RS11900	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AC028_RS11930	COG0406	alpha-ribazole phosphatase activity
AC028_RS11935	COG0285	dihydrofolate synthase activity
AC028_RS11955	COG2833	Protein of unknown function (DUF455)
AC028_RS11975	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC028_RS11980	COG0671	phosphoesterase, PA-phosphatase related
AC028_RS11985	COG0438	transferase activity, transferring glycosyl groups
AC028_RS11995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AC028_RS12010	COG4783	chaperone-mediated protein folding
AC028_RS12025	COG0473	3-isopropylmalate dehydrogenase activity
AC028_RS12070	COG0544	peptidyl-prolyl cis-trans isomerase activity
AC028_RS12080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AC028_RS12110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC028_RS12120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC028_RS12130	COG0328	RNA-DNA hybrid ribonuclease activity
AC028_RS12135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC028_RS12140	COG0631	protein serine/threonine phosphatase activity
AC028_RS12155	COG0859	PFAM glycosyl transferase family 9
AC028_RS12160	COG3642	lipopolysaccharide core region biosynthetic process
AC028_RS12165	COG1234	tRNA 3'-trailer cleavage
AC028_RS12170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AC028_RS12180	COG0315	cyclic pyranopterin monophosphate synthase activity
AC028_RS12185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AC028_RS12190	COG0314	molybdopterin synthase activity
AC028_RS12210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AC028_RS12215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AC028_RS12220	COG0537	adenosine 5'-monophosphoramidase activity
AC028_RS12240	COG0714	Associated with various cellular activities
AC028_RS12265	COG0424	maF-like protein
AC028_RS12270	COG1399	metal-binding, possibly nucleic acid-binding protein
AC028_RS12280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC028_RS12290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AC028_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS12310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AC028_RS12315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AC028_RS12340	COG3829	transcription factor binding
AC028_RS12385	COG2373	Large extracellular alpha-helical protein
AC028_RS12405	COG4953	penicillin-binding protein 1C
AC028_RS12415	COG0678	peroxiredoxin activity
AC028_RS12435	COG0330	HflC and HflK could
AC028_RS12440	COG0330	HflC and HflK could
AC028_RS12450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AC028_RS12455	COG0308	aminopeptidase N
AC028_RS12460	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS12465	COG1309	transcriptional regulator
AC028_RS12520	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AC028_RS12525	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AC028_RS12530	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AC028_RS12535	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AC028_RS12570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC028_RS12585	COG3387	PFAM Glycoside hydrolase 15-related
AC028_RS12590	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS12600	COG3537	Alpha-1,2-mannosidase
AC028_RS12605	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS12620	COG0492	ferredoxin-NADP+ reductase activity
AC028_RS12650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC028_RS12655	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC028_RS12660	COG2080	2 iron, 2 sulfur cluster binding
AC028_RS12695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC028_RS12715	COG0587	DNA-directed DNA polymerase activity
AC028_RS12730	COG1297	OPT oligopeptide transporter protein
AC028_RS12745	COG0823	Involved in the tonB-independent uptake of proteins
AC028_RS12745	COG1506	peptidase
AC028_RS12750	COG2963	transposase activity
AC028_RS12775	COG1917	Cupin 2, conserved barrel domain protein
AC028_RS12775	COG2207	Transcriptional regulator
AC028_RS12790	COG0753	catalase activity
AC028_RS12795	COG0656	L-ascorbic acid biosynthetic process
AC028_RS12805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC028_RS12805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC028_RS12810	COG2814	Major facilitator Superfamily
AC028_RS12825	COG2194	sulfuric ester hydrolase activity
AC028_RS12840	COG0745	RESPONSE REGULATOR receiver
AC028_RS12845	COG0642	Histidine kinase
AC028_RS12855	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AC028_RS12860	COG2894	cell division
AC028_RS12865	COG0850	regulation of cytokinetic process
AC028_RS12880	COG4585	Histidine kinase
AC028_RS12885	COG2197	response regulator
AC028_RS12900	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AC028_RS12925	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AC028_RS12935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AC028_RS12955	COG1946	Acyl-CoA thioesterase
AC028_RS12970	COG0824	Thioesterase
AC028_RS12975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AC028_RS12980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AC028_RS12985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AC028_RS12990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AC028_RS12995	COG0268	Binds directly to 16S ribosomal RNA
AC028_RS13005	COG0196	riboflavin kinase activity
AC028_RS13010	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AC028_RS13015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AC028_RS13020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AC028_RS13055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AC028_RS13060	COG1845	cytochrome c oxidase, subunit III
AC028_RS13065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AC028_RS13080	COG3152	Membrane
AC028_RS13090	COG2207	Transcriptional regulator
AC028_RS13095	COG0326	Molecular chaperone. Has ATPase activity
AC028_RS13105	COG1366	Belongs to the anti-sigma-factor antagonist family
AC028_RS13110	COG1366	Belongs to the anti-sigma-factor antagonist family
AC028_RS13115	COG2172	sigma factor antagonist activity
AC028_RS13140	COG4771	TonB-dependent receptor
AC028_RS13150	COG5507	3-demethylubiquinone-9 3-methyltransferase
AC028_RS13160	COG2205	protein histidine kinase activity
AC028_RS13170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AC028_RS13175	COG3437	response regulator, receiver
AC028_RS13175	COG3850	Histidine kinase
AC028_RS13175	COG2205	protein histidine kinase activity
AC028_RS13175	COG4999	Histidine kinase
AC028_RS13180	COG0784	Response regulator, receiver
AC028_RS13180	COG4191	Histidine kinase
AC028_RS13205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC028_RS13210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AC028_RS13225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC028_RS13230	COG0228	four-way junction DNA binding
AC028_RS13235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AC028_RS13240	COG0336	Belongs to the RNA methyltransferase TrmD family
AC028_RS13245	COG0335	large ribosomal subunit rRNA binding
AC028_RS13250	COG0534	Mate efflux family protein
AC028_RS13275	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AC028_RS13285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AC028_RS13295	COG3483	tryptophan 2,3-dioxygenase activity
AC028_RS13305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC028_RS13310	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS13335	COG3250	beta-galactosidase activity
AC028_RS13340	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AC028_RS13360	COG1960	acyl-CoA dehydrogenase activity
AC028_RS13365	COG1024	Enoyl-CoA hydratase
AC028_RS13405	COG3039	Transposase
AC028_RS13410	COG3039	Transposase
AC028_RS13430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AC028_RS13430	COG2755	lipolytic protein G-D-S-L family
AC028_RS13435	COG4221	oxidoreductase activity
AC028_RS13450	COG0018	arginyl-trna synthetase
AC028_RS13455	COG2003	Belongs to the UPF0758 family
AC028_RS13460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AC028_RS13465	COG0756	dUTP diphosphatase activity
AC028_RS13485	COG0463	Glycosyl transferase, family 2
AC028_RS13505	COG1475	DNA binding
AC028_RS13510	COG1192	Involved in chromosome partitioning
AC028_RS13520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AC028_RS13525	COG0708	Exodeoxyribonuclease III
AC028_RS13530	COG2211	Major facilitator Superfamily
AC028_RS13540	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AC028_RS13545	COG0739	heme binding
AC028_RS13550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AC028_RS13595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AC028_RS13610	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AC028_RS13640	COG0109	protoheme IX farnesyltransferase activity
AC028_RS13655	COG0358	DNA primase activity
AC028_RS13660	COG1295	ribonuclease BN
AC028_RS13670	COG1610	YqeY-like protein
AC028_RS13680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AC028_RS13685	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AC028_RS13695	COG2133	pyrroloquinoline quinone binding
AC028_RS13700	COG4682	membrane
AC028_RS13715	COG0531	amino acid
AC028_RS13725	COG4948	Mandelate Racemase Muconate Lactonizing
AC028_RS13735	COG3023	N-Acetylmuramoyl-L-alanine amidase
AC028_RS13740	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AC028_RS13785	COG5383	Protein conserved in bacteria
AC028_RS13805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC028_RS13810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_RS13815	COG1473	amidohydrolase
AC028_RS13820	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC028_RS13820	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC028_RS13845	COG0583	DNA-binding transcription factor activity
AC028_RS13850	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AC028_RS13855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AC028_RS13860	COG3118	belongs to the thioredoxin family
AC028_RS13865	COG0513	Belongs to the DEAD box helicase family
AC028_RS13870	COG2884	Cell division ATP-binding protein ftsE
AC028_RS13875	COG2177	Part of the ABC transporter FtsEX involved in
AC028_RS13880	COG3437	response regulator, receiver
AC028_RS13885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AC028_RS13890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC028_RS13895	COG2860	membrane
AC028_RS13900	COG1252	NADH dehydrogenase
AC028_RS13915	COG0625	glutathione transferase activity
AC028_RS13940	COG0534	Mate efflux family protein
AC028_RS13945	COG0616	signal peptide processing
AC028_RS13960	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS13975	COG0009	L-threonylcarbamoyladenylate synthase
AC028_RS13980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AC028_RS13980	COG1754	DNA topoisomerase type I activity
AC028_RS14000	COG0758	DNA mediated transformation
AC028_RS14005	COG1652	LysM domain
AC028_RS14010	COG0242	peptide deformylase activity
AC028_RS14015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AC028_RS14020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AC028_RS14020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC028_RS14075	COG1560	Kdo2-lipid A biosynthetic process
AC028_RS14080	COG1490	D-aminoacyl-tRNA deacylase activity
AC028_RS14085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC028_RS14235	COG0840	transmembrane signaling receptor activity
AC028_RS14250	COG0251	oxidation-reduction process
AC028_RS14325	COG1063	alcohol dehydrogenase
AC028_RS14340	COG1132	(ABC) transporter
AC028_RS14360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AC028_RS14365	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS14380	COG1294	oxidase, subunit
AC028_RS14385	COG1271	oxidase subunit
AC028_RS14400	COG2204	response regulator
AC028_RS14435	COG3546	catalase activity
AC028_RS14440	COG3685	Protein conserved in bacteria
AC028_RS14460	COG2972	Histidine kinase
AC028_RS14475	COG0531	amino acid
AC028_RS14490	COG3590	peptidase
AC028_RS14505	COG0667	Aldo Keto reductase
AC028_RS14515	COG0583	DNA-binding transcription factor activity
AC028_RS14525	COG3384	dioxygenase
AC028_RS14535	COG1573	uracil-dna glycosylase
AC028_RS14540	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AC028_RS14550	COG0025	NhaP-type Na H and K H
AC028_RS14555	COG1131	(ABC) transporter
AC028_RS14560	COG0842	Transport permease protein
AC028_RS14615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC028_RS14620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AC028_RS14640	COG2205	protein histidine kinase activity
AC028_RS14640	COG2202	Pas domain
AC028_RS14660	COG2813	Specifically methylates the guanine in position
AC028_RS14665	COG1187	pseudouridine synthase activity
AC028_RS14670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AC028_RS14695	COG5002	protein histidine kinase activity
AC028_RS14695	COG2198	Histidine kinase
AC028_RS14695	COG0784	Response regulator, receiver
AC028_RS14705	COG1666	GTP binding
AC028_RS14710	COG0697	spore germination
AC028_RS14715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AC028_RS14720	COG2011	ABC-type metal ion transport system permease component
AC028_RS14745	COG3039	Transposase
AC028_RS14765	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC028_RS14775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC028_RS14795	COG0356	it plays a direct role in the translocation of protons across the membrane
AC028_RS14805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AC028_RS14810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AC028_RS14815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AC028_RS14820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AC028_RS14825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AC028_RS14830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AC028_RS14850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AC028_RS14855	COG4191	Histidine kinase
AC028_RS14870	COG0577	efflux transmembrane transporter activity
AC028_RS14870	COG1136	(ABC) transporter
AC028_RS14875	COG0577	efflux transmembrane transporter activity
AC028_RS14880	COG3039	Transposase
AC028_RS14885	COG1136	(ABC) transporter
AC028_RS14890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_RS14895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AC028_RS14930	COG2132	Multicopper oxidase
AC028_RS14945	COG0339	signal peptide processing
AC028_RS14960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC028_RS14965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AC028_RS14970	COG0546	phosphoglycolate phosphatase activity
AC028_RS14980	COG2819	hydrolase of the alpha beta superfamily
AC028_RS14990	COG1956	GAF domain-containing protein
AC028_RS14995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AC028_RS15005	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AC028_RS15015	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AC028_RS15025	COG0720	synthase
AC028_RS15035	COG4771	TonB-dependent receptor
AC028_RS15045	COG0513	Belongs to the DEAD box helicase family
AC028_RS15060	COG0625	glutathione transferase activity
AC028_RS15090	COG0626	cystathionine gamma-synthase activity
AC028_RS15100	COG0438	transferase activity, transferring glycosyl groups
AC028_RS15120	COG0438	transferase activity, transferring glycosyl groups
AC028_RS15125	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AC028_RS15135	COG2963	transposase activity
AC028_RS15165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC028_RS15175	COG0277	FAD linked oxidase domain protein
AC028_RS15180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AC028_RS15180	COG0546	phosphoglycolate phosphatase activity
AC028_RS15195	COG2086	electron transfer activity
AC028_RS15225	COG0662	Cupin 2, conserved barrel domain protein
AC028_RS15225	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AC028_RS15230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC028_RS15260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC028_RS15260	COG3218	ABC-type transport auxiliary lipoprotein component
AC028_RS15265	COG1127	ABC transporter
AC028_RS15270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC028_RS15305	COG1131	(ABC) transporter
AC028_RS15310	COG0346	lactoylglutathione lyase activity
AC028_RS15315	COG0833	amino acid
AC028_RS15320	COG2040	homocysteine
AC028_RS15330	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AC028_RS15350	COG1695	Transcriptional regulator
AC028_RS15370	COG1981	membrane
AC028_RS15385	COG0825	malonyl-CoA metabolic process
AC028_RS15400	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC028_RS15405	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC028_RS15410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC028_RS15415	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC028_RS15430	COG0750	zinc metalloprotease
AC028_RS15435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AC028_RS15440	COG0575	Belongs to the CDS family
AC028_RS15445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AC028_RS15450	COG0233	cytoplasmic translational termination
AC028_RS15455	COG0528	UMP kinase activity
AC028_RS15465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AC028_RS15470	COG0052	Belongs to the universal ribosomal protein uS2 family
AC028_RS15510	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AC028_RS15520	COG1393	Belongs to the ArsC family
AC028_RS15525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC028_RS15530	COG0367	asparagine synthase
AC028_RS15540	COG4774	siderophore transport
AC028_RS15555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC028_RS15580	COG1566	PFAM secretion protein HlyD family protein
AC028_RS15585	COG2814	Major facilitator Superfamily
AC028_RS15605	COG3104	oligopeptide transport
AC028_RS15635	COG0339	signal peptide processing
AC028_RS15645	COG0386	Belongs to the glutathione peroxidase family
AC028_RS15700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AC028_RS15705	COG0084	hydrolase, TatD family'
AC028_RS15720	COG1960	acyl-CoA dehydrogenase activity
AC028_RS15740	COG0367	asparagine synthase
AC028_RS15750	COG0305	Participates in initiation and elongation during chromosome replication
AC028_RS15755	COG0415	Belongs to the DNA photolyase family
AC028_RS15765	COG0583	DNA-binding transcription factor activity
AC028_RS15810	COG3706	GGDEF domain
AC028_RS15845	COG0322	excinuclease ABC activity
AC028_RS15850	COG1484	DNA-dependent DNA replication
AC028_RS15855	COG4584	PFAM Integrase catalytic
AC028_RS15885	COG3039	Transposase
AC028_RS15900	COG1595	DNA-templated transcription, initiation
AC028_RS15905	COG3712	iron ion homeostasis
AC028_RS15925	COG4206	TonB-dependent receptor
AC028_RS15940	COG3039	Transposase
AC028_RS15955	COG3039	Transposase
AC028_RS15965	COG1162	GTPase activity
AC028_RS15995	COG2211	Major facilitator Superfamily
AC028_RS16000	COG1609	Transcriptional regulator
AC028_RS16005	COG3039	Transposase
AC028_RS16010	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS16015	COG2851	Citrate transporter
AC028_RS16035	COG0642	Histidine kinase
AC028_RS16050	COG2197	response regulator
AC028_RS16065	COG0667	Aldo Keto reductase
AC028_RS16075	COG0583	DNA-binding transcription factor activity
AC028_RS16100	COG1301	dicarboxylic acid transport
AC028_RS16105	COG0281	malic enzyme
AC028_RS16105	COG0280	phosphate acetyltransferase
AC028_RS16155	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AC028_RS16170	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC028_RS16180	COG0497	DNA recombination
AC028_RS16185	COG1420	regulation of RNA biosynthetic process
AC028_RS16190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AC028_RS16195	COG0443	Heat shock 70 kDa protein
AC028_RS16200	COG0484	heat shock protein binding
AC028_RS16210	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AC028_RS16240	COG0583	DNA-binding transcription factor activity
AC028_RS16245	COG1132	(ABC) transporter
AC028_RS16260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC028_RS16270	COG0567	Dehydrogenase, E1 component
AC028_RS16280	COG2850	peptidyl-arginine hydroxylation
AC028_RS16305	COG1253	flavin adenine dinucleotide binding
AC028_RS16340	COG1131	(ABC) transporter
AC028_RS16345	COG1725	Transcriptional regulator
AC028_RS16355	COG0386	Belongs to the glutathione peroxidase family
AC028_RS16370	COG2900	Belongs to the SlyX family
AC028_RS16395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC028_RS16405	COG1410	methionine synthase
AC028_RS16405	COG0646	methionine synthase
AC028_RS16410	COG1410	methionine synthase
AC028_RS16410	COG0646	methionine synthase
AC028_RS16415	COG2226	methyltransferase
AC028_RS16420	COG1960	acyl-CoA dehydrogenase activity
AC028_RS16425	COG1960	acyl-CoA dehydrogenase activity
AC028_RS16430	COG1960	acyl-CoA dehydrogenase activity
AC028_RS16435	COG1960	acyl-CoA dehydrogenase activity
AC028_RS16440	COG1960	acyl-CoA dehydrogenase activity
AC028_RS16445	COG1960	acyl-CoA dehydrogenase activity
AC028_RS16450	COG1960	acyl-CoA dehydrogenase activity
AC028_RS16455	COG1960	acyl-CoA dehydrogenase activity
AC028_RS16460	COG1960	acyl-CoA dehydrogenase activity
AC028_RS16480	COG0557	exoribonuclease II activity
AC028_RS16500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC028_RS16510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC028_RS16520	COG0704	Plays a role in the regulation of phosphate uptake
AC028_RS16525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AC028_RS16530	COG0581	inorganic phosphate transmembrane transporter activity
AC028_RS16535	COG0573	inorganic phosphate transmembrane transporter activity
AC028_RS16540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AC028_RS16565	COG0659	secondary active sulfate transmembrane transporter activity
AC028_RS16570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AC028_RS16580	COG1024	Enoyl-CoA hydratase
AC028_RS16590	COG0494	nUDIX hydrolase
AC028_RS16625	COG0488	(ABC) transporter
AC028_RS16635	COG0116	Belongs to the methyltransferase superfamily
AC028_RS16635	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC028_RS16640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AC028_RS16660	COG2925	Exonuclease
AC028_RS16665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC028_RS16670	COG3844	kynureninase activity
AC028_RS16680	COG0662	Cupin 2, conserved barrel domain protein
AC028_RS16685	COG0288	reversible hydration of carbon dioxide
AC028_RS16770	COG0017	Asparaginyl-tRNA synthetase
AC028_RS16780	COG0316	Belongs to the HesB IscA family
AC028_RS16785	COG0360	Binds together with S18 to 16S ribosomal RNA
AC028_RS16790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AC028_RS16795	COG0359	binds to the 23S rRNA
AC028_RS16810	COG3115	cell septum assembly
AC028_RS16825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AC028_RS16830	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AC028_RS16845	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AC028_RS16855	COG4993	Dehydrogenase
AC028_RS16865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AC028_RS16875	COG2986	histidine ammonia-lyase
AC028_RS16880	COG1228	amidohydrolase
AC028_RS16920	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AC028_RS16930	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AC028_RS16935	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AC028_RS16940	COG1605	Chorismate mutase
AC028_RS16940	COG0077	Prephenate dehydratase
AC028_RS16945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AC028_RS16960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AC028_RS16965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AC028_RS16970	COG0583	DNA-binding transcription factor activity
AC028_RS16985	COG0840	transmembrane signaling receptor activity
AC028_RS17015	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AC028_RS17020	COG0784	Response regulator, receiver
AC028_RS17020	COG4191	Histidine kinase
AC028_RS17035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC028_RS17045	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC028_RS17055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC028_RS17070	COG1595	DNA-templated transcription, initiation
AC028_RS17125	COG2244	polysaccharide biosynthetic process
AC028_RS17155	COG2264	protein methyltransferase activity
AC028_RS17180	COG1136	(ABC) transporter
AC028_RS17190	COG0477	Major facilitator Superfamily
AC028_RS17195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC028_RS17210	COG1253	flavin adenine dinucleotide binding
AC028_RS17225	COG0306	phosphate transporter
AC028_RS17250	COG0504	CTP synthase activity
AC028_RS17265	COG0148	phosphopyruvate hydratase activity
AC028_RS17270	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AC028_RS17275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AC028_RS17280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AC028_RS17285	COG0585	pseudouridine synthase activity
AC028_RS17290	COG2840	Smr protein MutS2
AC028_RS17295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AC028_RS17300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC028_RS17305	COG1238	metal cluster binding
AC028_RS17320	COG1534	Rna-binding protein
AC028_RS17325	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AC028_RS17335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AC028_RS17340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AC028_RS17350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AC028_RS17355	COG1546	Belongs to the CinA family
AC028_RS17365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC028_RS17370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AC028_RS17380	COG2137	regulation of response to DNA damage stimulus
AC028_RS17385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AC028_RS17390	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AC028_RS17410	COG1741	Belongs to the pirin family
AC028_RS17415	COG0583	DNA-binding transcription factor activity
AC028_RS17440	COG0351	phosphomethylpyrimidine kinase
AC028_RS17455	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AC028_RS17460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AC028_RS17475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC028_RS17485	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AC028_RS17490	COG3734	2-keto-3-deoxy-galactonokinase
AC028_RS17500	COG4948	Mandelate Racemase Muconate Lactonizing
AC028_RS17505	COG0800	Aldolase
AC028_RS17545	COG1501	Belongs to the glycosyl hydrolase 31 family
AC028_RS17555	COG1070	Carbohydrate kinase
AC028_RS17560	COG2115	Belongs to the xylose isomerase family
AC028_RS17565	COG0477	Major facilitator Superfamily
AC028_RS17590	COG1469	GTP cyclohydrolase I activity
AC028_RS17610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AC028_RS17615	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AC028_RS17620	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AC028_RS17645	COG1472	Belongs to the glycosyl hydrolase 3 family
AC028_RS17660	COG2203	Gaf domain
AC028_RS17660	COG3706	GGDEF domain
AC028_RS17660	COG4251	negative regulation of phosphorylation
AC028_RS17660	COG5001	Diguanylate cyclase
AC028_RS17665	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC028_RS17670	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AC028_RS17680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AC028_RS17685	COG0671	phosphoesterase, PA-phosphatase related
AC028_RS17695	COG1794	racemase activity, acting on amino acids and derivatives
AC028_RS17705	COG0697	spore germination
AC028_RS17710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AC028_RS17715	COG0167	dihydroorotate dehydrogenase activity
AC028_RS17730	COG1012	belongs to the aldehyde dehydrogenase family
AC028_RS17740	COG3039	Transposase
AC028_RS17770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AC028_RS17780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC028_RS17785	COG0124	histidyl-tRNA synthetase
AC028_RS17795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AC028_RS17800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AC028_RS17805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC028_RS17810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AC028_RS17810	COG0131	Imidazoleglycerol-phosphate dehydratase
AC028_RS17815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AC028_RS17820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AC028_RS17825	COG0107	imidazoleglycerol-phosphate synthase activity
AC028_RS17830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AC028_RS17830	COG0140	phosphoribosyl-ATP diphosphatase activity
AC028_RS17850	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AC028_RS17855	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AC028_RS17860	COG0235	Class ii aldolase
AC028_RS17865	COG0531	amino acid
AC028_RS17870	COG0531	amino acid
AC028_RS17880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AC028_RS17885	COG0277	FAD linked oxidase domain protein
AC028_RS17905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC028_RS17950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC028_RS17955	COG2258	MOSC domain
AC028_RS17960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AC028_RS17965	COG0505	Belongs to the CarA family
AC028_RS17975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AC028_RS17980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC028_RS17990	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AC028_RS18000	COG3279	Response regulator of the LytR AlgR family
AC028_RS18005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AC028_RS18010	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AC028_RS18020	COG0784	Response regulator, receiver
AC028_RS18020	COG2205	protein histidine kinase activity
AC028_RS18020	COG2198	Histidine kinase
AC028_RS18025	COG0784	Response regulator, receiver
AC028_RS18025	COG2198	Histidine kinase
AC028_RS18025	COG2205	protein histidine kinase activity
AC028_RS18030	COG1024	Enoyl-CoA hydratase
AC028_RS18065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC028_RS18075	COG2201	protein-glutamate methylesterase activity
AC028_RS18080	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AC028_RS18090	COG0840	transmembrane signaling receptor activity
AC028_RS18105	COG0835	chemotaxis
AC028_RS18120	COG0840	transmembrane signaling receptor activity
AC028_RS18130	COG0840	transmembrane signaling receptor activity
AC028_RS18135	COG0840	transmembrane signaling receptor activity
AC028_RS18140	COG0840	transmembrane signaling receptor activity
AC028_RS18145	COG0840	transmembrane signaling receptor activity
AC028_RS18155	COG0840	transmembrane signaling receptor activity
AC028_RS18170	COG0840	transmembrane signaling receptor activity
AC028_RS18185	COG0840	transmembrane signaling receptor activity
AC028_RS18205	COG0840	transmembrane signaling receptor activity
AC028_RS18215	COG0745	RESPONSE REGULATOR receiver
AC028_RS18225	COG0835	chemotaxis
AC028_RS18235	COG1360	Flagellar Motor Protein
AC028_RS18240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AC028_RS18320	COG0784	Response regulator, receiver
AC028_RS18320	COG2198	Histidine kinase
AC028_RS18320	COG0643	Histidine kinase
AC028_RS18380	COG1684	flagellar biosynthetic protein fliR
AC028_RS18400	COG3190	flagellar
AC028_RS18450	COG1677	Flagellar hook-basal body complex protein FliE
AC028_RS18515	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS18520	COG3039	Transposase
AC028_RS18530	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS18535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC028_RS18555	COG2201	protein-glutamate methylesterase activity
AC028_RS18585	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AC028_RS18595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AC028_RS18605	COG3951	Flagellar rod assembly protein muramidase FlgJ
AC028_RS18605	COG1705	Flagellar rod assembly protein muramidase FlgJ
AC028_RS18610	COG1706	bacterial-type flagellum-dependent cell motility
AC028_RS18615	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AC028_RS18630	COG4787	bacterial-type flagellum-dependent cell motility
AC028_RS18640	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AC028_RS18645	COG1558	bacterial-type flagellum-dependent cell motility
AC028_RS18655	COG0835	chemotaxis
AC028_RS18655	COG0784	Response regulator, receiver
AC028_RS18675	COG5002	protein histidine kinase activity
AC028_RS18705	COG2915	High frequency lysogenization protein hflD homolog
AC028_RS18710	COG0482	sulfurtransferase activity
AC028_RS18725	COG0542	response to heat
AC028_RS18735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AC028_RS18745	COG0492	ferredoxin-NADP+ reductase activity
AC028_RS18750	COG1674	ftsk spoiiie
AC028_RS18760	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AC028_RS18770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AC028_RS18775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC028_RS18785	COG0183	Belongs to the thiolase family
AC028_RS18790	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC028_RS18790	COG1024	Enoyl-CoA hydratase
AC028_RS18805	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AC028_RS18815	COG1426	Protein conserved in bacteria
AC028_RS18825	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC028_RS18830	COG1160	GTP binding
AC028_RS18835	COG0303	'Molybdopterin
AC028_RS18840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AC028_RS18880	COG0708	Exodeoxyribonuclease III
AC028_RS18890	COG0303	'Molybdopterin
AC028_RS18895	COG0746	molybdenum cofactor guanylyltransferase activity
AC028_RS18925	COG1914	H( )-stimulated, divalent metal cation uptake system
AC028_RS18940	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AC028_RS18945	COG0668	transmembrane transport
AC028_RS18955	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AC028_RS18970	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS18975	COG1183	phosphatidylcholine synthase activity
AC028_RS18985	COG3243	poly(R)-hydroxyalkanoic acid synthase
AC028_RS19000	COG0723	plastoquinol--plastocyanin reductase activity
AC028_RS19000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC028_RS19010	COG2183	response to ionizing radiation
AC028_RS19080	COG0800	Aldolase
AC028_RS19085	COG0129	dihydroxy-acid dehydratase activity
AC028_RS19090	COG0363	glucosamine-6-phosphate deaminase activity
AC028_RS19095	COG0837	glucose binding
AC028_RS19100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC028_RS19110	COG0354	folic acid binding
AC028_RS19125	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AC028_RS19140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AC028_RS19145	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AC028_RS19155	COG4591	ABC-type transport system involved in lipoprotein release permease component
AC028_RS19160	COG1136	(ABC) transporter
AC028_RS19175	COG0811	peptide transport
AC028_RS19180	COG0848	biopolymer transport protein
AC028_RS19185	COG1132	(ABC) transporter
AC028_RS19190	COG1663	tetraacyldisaccharide 4'-kinase activity
AC028_RS19195	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AC028_RS19200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC028_RS19220	COG0322	excinuclease ABC activity
AC028_RS19225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC028_RS19250	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AC028_RS19270	COG1054	Belongs to the UPF0176 family
AC028_RS19290	COG3064	Membrane
AC028_RS19295	COG0428	transporter
AC028_RS19305	COG2154	pterin-4-alpha-carbinolamine dehydratase
AC028_RS19310	COG0316	Belongs to the HesB IscA family
AC028_RS19310	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AC028_RS19340	COG2951	lytic endotransglycosylase activity
AC028_RS19345	COG4644	lycopene metabolic process
AC028_RS19380	COG3920	Histidine kinase
AC028_RS19405	COG3039	Transposase
AC028_RS19430	COG0583	DNA-binding transcription factor activity
AC028_RS19445	COG2963	transposase activity
AC028_RS19465	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS19470	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AC028_RS19475	COG2226	methyltransferase
AC028_RS19475	COG1073	alpha beta
AC028_RS19515	COG5001	Diguanylate cyclase
AC028_RS19535	COG3685	Protein conserved in bacteria
AC028_RS19550	COG0243	molybdopterin cofactor binding
AC028_RS19555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC028_RS19555	COG1648	precorrin-2 dehydrogenase activity
AC028_RS19570	COG2814	Major facilitator Superfamily
AC028_RS19585	COG1335	isochorismatase
AC028_RS19615	COG0583	DNA-binding transcription factor activity
AC028_RS19620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC028_RS19625	COG3002	Belongs to the UPF0753 family
AC028_RS19640	COG2801	Transposase and inactivated derivatives
AC028_RS19680	COG0582	viral genome integration into host DNA
AC028_RS19685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC028_RS19685	COG0519	Catalyzes the synthesis of GMP from XMP
AC028_RS19695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AC028_RS19710	COG0475	glutathione-regulated potassium exporter activity
AC028_RS19710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC028_RS19715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AC028_RS19725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC028_RS19730	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AC028_RS19740	COG0776	regulation of translation
AC028_RS19745	COG0539	negative regulation of cytoplasmic translation
AC028_RS19765	COG2957	Belongs to the agmatine deiminase family
AC028_RS19770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC028_RS19795	COG0395	ABC-type sugar transport system, permease component
AC028_RS19830	COG2350	Protein conserved in bacteria
AC028_RS19835	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AC028_RS19840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AC028_RS19845	COG1187	pseudouridine synthase activity
AC028_RS19865	COG0436	Aminotransferase
AC028_RS19870	COG4133	protoheme IX ABC transporter activity
AC028_RS19890	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC028_RS19895	COG1138	Cytochrome C-type biogenesis protein
AC028_RS19915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC028_RS19920	COG1278	Cold shock
AC028_RS19925	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AC028_RS19930	COG4988	ABC transporter
AC028_RS19940	COG1294	oxidase, subunit
AC028_RS19970	COG1476	TRANSCRIPTIONal
AC028_RS19975	COG0464	growth
AC028_RS20090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AC028_RS20095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AC028_RS20105	COG0165	Argininosuccinate lyase
AC028_RS20110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AC028_RS20120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AC028_RS20125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC028_RS20135	COG0137	argininosuccinate synthase activity
AC028_RS20140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AC028_RS20150	COG0215	cysteine-tRNA ligase activity
AC028_RS20155	COG2166	iron-sulfur cluster assembly
AC028_RS20170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AC028_RS20175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC028_RS20195	COG4302	ethanolamine ammonia-lyase activity
AC028_RS20255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AC028_RS20260	COG0402	S-adenosylhomocysteine deaminase activity
AC028_RS20270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC028_RS20275	COG1509	lysine 2,3-aminomutase activity
AC028_RS20280	COG5001	Diguanylate cyclase
AC028_RS20280	COG3300	MHYT domain
AC028_RS20295	COG0483	inositol monophosphate 1-phosphatase activity
AC028_RS20300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AC028_RS20320	COG0488	(ABC) transporter
AC028_RS20325	COG0513	Belongs to the DEAD box helicase family
AC028_RS20330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AC028_RS20335	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AC028_RS20345	COG0625	glutathione transferase activity
AC028_RS20355	COG4681	YaeQ
AC028_RS20360	COG2081	HI0933 family
AC028_RS20370	COG0501	Belongs to the peptidase M48B family
AC028_RS20375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC028_RS20380	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_RS20410	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC028_RS20415	COG0802	atpase or kinase
AC028_RS20420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AC028_RS20420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC028_RS20425	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AC028_RS20430	COG1570	exodeoxyribonuclease VII activity
AC028_RS20440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC028_RS20490	COG0835	chemotaxis
AC028_RS20495	COG0840	transmembrane signaling receptor activity
AC028_RS20500	COG2094	Belongs to the DNA glycosylase MPG family
AC028_RS20505	COG1201	RNA secondary structure unwinding
AC028_RS20525	COG2969	positive regulation of protein catabolic process
AC028_RS20530	COG0625	glutathione transferase activity
AC028_RS20535	COG2857	Cytochrome c1
AC028_RS20540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AC028_RS20545	COG0723	plastoquinol--plastocyanin reductase activity
AC028_RS20555	COG0741	lytic transglycosylase activity
AC028_RS20570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC028_RS20575	COG1702	phosphate starvation-inducible protein PhoH
AC028_RS20585	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AC028_RS20595	COG4535	Mg2 and Co2 transporter CorC
AC028_RS20610	COG1012	belongs to the aldehyde dehydrogenase family
AC028_RS20615	COG1177	transmembrane transport
AC028_RS20620	COG1176	ABC-type spermidine putrescine transport system, permease component I
AC028_RS20630	COG3842	ATPase activity
AC028_RS20650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AC028_RS20665	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AC028_RS20670	COG0174	glutamine synthetase
AC028_RS20675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC028_RS20685	COG2703	oxygen carrier activity
AC028_RS20690	COG0477	Major facilitator Superfamily
AC028_RS20710	COG0243	molybdopterin cofactor binding
AC028_RS20715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AC028_RS20720	COG2223	nitrite transmembrane transporter activity
AC028_RS20735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AC028_RS20745	COG2733	membrane
AC028_RS20750	COG2205	protein histidine kinase activity
AC028_RS20750	COG5002	protein histidine kinase activity
AC028_RS20750	COG0784	Response regulator, receiver
AC028_RS20765	COG0477	Major facilitator Superfamily
AC028_RS20795	COG2902	Dehydrogenase
AC028_RS20805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_RS20810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC028_RS20815	COG1609	Transcriptional regulator
AC028_RS20820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC028_RS20820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC028_RS20825	COG1105	Belongs to the carbohydrate kinase PfkB family
AC028_RS20830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC028_RS20830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC028_RS20855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AC028_RS20865	COG1862	Preprotein translocase
AC028_RS20870	COG0343	queuine tRNA-ribosyltransferase activity
AC028_RS20875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AC028_RS20910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AC028_RS20920	COG3291	Pkd domain containing protein
AC028_RS20925	COG0405	Gamma-glutamyltransferase
AC028_RS20930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AC028_RS20945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AC028_RS20950	COG0742	ribosomal rna small subunit methyltransferase
AC028_RS20955	COG0326	Molecular chaperone. Has ATPase activity
AC028_RS20980	COG3039	Transposase
AC028_RS21055	COG0531	amino acid
AC028_RS21070	COG0006	proline dipeptidase activity
AC028_RS21080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC028_RS21095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC028_RS21100	COG3938	Belongs to the proline racemase family
AC028_RS21110	COG0552	protein localization to endoplasmic reticulum
AC028_RS21120	COG1194	a g-specific adenine glycosylase
AC028_RS21125	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AC028_RS21130	COG0784	Response regulator, receiver
AC028_RS21130	COG4191	Histidine kinase
AC028_RS21145	COG0322	excinuclease ABC activity
AC028_RS21160	COG3040	lipid binding
AC028_RS21170	COG1960	acyl-CoA dehydrogenase activity
AC028_RS21180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AC028_RS21200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC028_RS21205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC028_RS21210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC028_RS21235	COG0438	transferase activity, transferring glycosyl groups
AC028_RS21245	COG0438	transferase activity, transferring glycosyl groups
AC028_RS21250	COG0438	transferase activity, transferring glycosyl groups
AC028_RS21300	COG0072	phenylalanine-tRNA ligase activity
AC028_RS21300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC028_RS21305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AC028_RS21320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AC028_RS21325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AC028_RS21380	COG3505	Type IV secretory pathway VirD4
AC028_RS21395	COG0556	nucleotide-excision repair
AC028_RS21400	COG4969	Belongs to the N-Me-Phe pilin family
AC028_RS21405	COG3039	Transposase
AC028_RS21455	COG4969	Belongs to the N-Me-Phe pilin family
AC028_RS21460	COG1611	Belongs to the LOG family
AC028_RS21475	COG2095	MarC family integral membrane protein
AC028_RS21485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC028_RS21520	COG1185	polyribonucleotide nucleotidyltransferase activity
AC028_RS21525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AC028_RS21530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AC028_RS21535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AC028_RS21540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AC028_RS21545	COG0195	Participates in both transcription termination and antitermination
AC028_RS21550	COG0779	Required for maturation of 30S ribosomal subunits
AC028_RS21560	COG1007	ATP synthesis coupled electron transport
AC028_RS21585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC028_RS21590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AC028_RS21600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AC028_RS21605	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AC028_RS21610	COG0649	NAD binding
AC028_RS21615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC028_RS21620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC028_RS21625	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC028_RS21640	COG0149	triose-phosphate isomerase activity
AC028_RS21645	COG0300	oxidoreductase activity
AC028_RS21650	COG3039	Transposase
AC028_RS21680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC028_RS21685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AC028_RS21690	COG0159	tryptophan synthase activity
AC028_RS21700	COG0133	tryptophan synthase activity
AC028_RS21710	COG0135	phosphoribosylanthranilate isomerase activity
AC028_RS21715	COG0101	tRNA pseudouridine synthase activity
AC028_RS21730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AC028_RS21735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC028_RS21740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AC028_RS21745	COG2890	protein-(glutamine-N5) methyltransferase activity
AC028_RS21755	COG0688	phosphatidylethanolamine metabolic process
AC028_RS21770	COG0433	COG0433 Predicted ATPase
AC028_RS21775	COG0494	nUDIX hydrolase
AC028_RS21795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC028_RS21800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC028_RS21825	COG0717	Belongs to the dCTP deaminase family
AC028_RS21835	COG0489	protein tyrosine kinase activity
AC028_RS21855	COG3590	peptidase
AC028_RS21860	COG3590	peptidase
AC028_RS21880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC028_RS21885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC028_RS21890	COG2311	Membrane
AC028_RS21895	COG1047	Peptidyl-prolyl cis-trans
AC028_RS21900	COG0791	NLP P60 protein
AC028_RS21905	COG0791	NLP P60 protein
AC028_RS21915	COG4106	trans-aconitate 2-methyltransferase activity
AC028_RS21920	COG1301	dicarboxylic acid transport
AC028_RS21925	COG1785	Belongs to the alkaline phosphatase family
AC028_RS21935	COG0037	tRNA processing
AC028_RS21940	COG1722	exodeoxyribonuclease VII activity
AC028_RS21945	COG0142	geranyltranstransferase activity
AC028_RS21955	COG4104	PAAR repeat-containing protein
AC028_RS21965	COG0312	modulator of DNA gyrase
AC028_RS21970	COG3028	Belongs to the UPF0307 family
AC028_RS21975	COG0312	modulator of DNA gyrase
AC028_RS21985	COG3164	Protein of unknown function
AC028_RS21995	COG0424	maF-like protein
AC028_RS22000	COG2968	Membrane
AC028_RS22015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AC028_RS22030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AC028_RS22045	COG0495	leucyl-tRNA aminoacylation
AC028_RS22055	COG3118	belongs to the thioredoxin family
AC028_RS22095	COG2155	Conserved Protein
AC028_RS22140	COG1132	(ABC) transporter
AC028_RS22150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC028_RS22170	COG0735	belongs to the Fur family
AC028_RS22175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC028_RS22200	COG4452	Inner membrane protein CreD
AC028_RS22210	COG2205	protein histidine kinase activity
AC028_RS22215	COG0745	RESPONSE REGULATOR receiver
AC028_RS22220	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AC028_RS22235	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AC028_RS22245	COG0643	Histidine kinase
AC028_RS22245	COG2198	Histidine kinase
AC028_RS22255	COG0840	transmembrane signaling receptor activity
AC028_RS22260	COG0835	chemotaxis
AC028_RS22295	COG3318	Belongs to the UPF0149 family
AC028_RS22295	COG3012	SEC-C Motif Domain Protein
AC028_RS22320	COG3077	Addiction module antitoxin, RelB DinJ family
AC028_RS22325	COG3041	Addiction module toxin RelE StbE family
AC028_RS22385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC028_RS22405	COG2948	multi-organism process
AC028_RS22410	COG3504	Conjugal transfer protein
AC028_RS22420	COG3704	protein secretion by the type IV secretion system
AC028_RS22485	COG1192	Involved in chromosome partitioning